Joseph Wong, MD
Professor
Medicine
School of Medicine

I have experience and training in general infectious diseases medicine and internal medicine with a focus on care of HIV+ patients. My research activity focuses on understanding how HIV persists in patients despite potent antiretroviral therapy and developing strategies to eliminate persistent viral reservoirs.

Education & Training

Show all (5) Hide

• Fellowship Infectious Diseases UC San Diego 06/1994
• Residency Internal Medicine McGaw Medical Ctr, Northwestern University 06/1989
• Internship Internal Medicine U.S. Naval Hospital 06/1983
• M.D. Medicine Northwestern University Medical School 06/1982
• B.S. Honors Program in Med Education Northwestern University 06/1980

Grants and Projects

Show all (10) Hide

• Understanding HIV latency reversal and clearance of infected cells in vivo, NIH, 2017-2022
• Evaluating HIV expression and latency in blood and tissues at the single cell level, NIH, 2014-2021
• Tissue Reservoirs of HIV in Victims of Sudden Death, NIH, 2015-2018
• Evaluating HIV expression and latency in blood and tissues at the single cell level, NIH, 2014-2016
• The contribution of Tcell tolerance to latent HIV infection, NIH, 2010-2014
• Role of Gut Associated Lymphoid Tissue in HIV Persistence, NIH, 2011-2014
• HIV-1 Adaptation in the Central Nervous System, NIH, 2005-2011
• Variation in Neurocognitive Impairment of HIV Ugandan Children by HIV Subtype, NIH, 2008-2011
• In Vivo Hiv Latency Revealed by Potent Antiviral Therapy, NIH, 1999-2005
• Characterizing Tissue Specific Hiv Drug Resistance, NIH, 1996-2001

Publications (130)

Top publication keywords:
Virus LatencyViral LoadAntiretroviral Therapy, Highly ActiveHIV-1RNA, ViralHIVHIV InfectionsVirus ActivationDNA, ViralVirus ReplicationProvirusesCD4-Positive T-LymphocytesViremiaAIDS Dementia ComplexAnti-HIV Agents

• Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers.
  PLoS pathogens 2013 Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, …
• Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers.
  AIDS (London, England) 2013 Hatano H, Somsouk M, Sinclair E, Harvill K, Gilman L, Cohen M, Hoh R, Hunt PW, Martin JN, Wong JK, Deeks SG, Yukl SA
• The distribution of HIV DNA and RNA in cell subsets differs in gut and blood of HIV-positive patients on ART: implications for viral persistence.
  The Journal of infectious diseases 2013 Yukl SA, Shergill AK, Ho T, Killian M, Girling V, Epling L, Li P, Wong LK, Crouch P, Deeks SG, Havlir DV, McQuaid K, Sinclair E, Wong JK
• Assessment of population-based HIV RNA levels in a rural east African setting using a fingerprick-based blood collection method.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012 Jain V, Liegler T, Kabami J, Chamie G, Clark TD, Black D, Geng EH, Kwarisiima D, Wong JK, Abdel-Mohsen M, Sonawane N, Aweeka FT, Thirumurthy H, Petersen ML, Charlebois ED, Kamya MR, Havlir DV, SEARCH …
• Higher HIV-1 genetic diversity is associated with AIDS and neuropsychological impairment.
  Virology 2012 Hightower GK, Wong JK, Letendre SL, Umlauf AA, Ellis RJ, Ignacio CC, Heaton RK, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Grant I, Little SJ, …
• Sudden cardiac death in patients with human immunodeficiency virus infection.
  Journal of the American College of Cardiology 2012 Tseng ZH, Secemsky EA, Dowdy D, Vittinghoff E, Moyers B, Wong JK, Havlir DV, Hsue PY
• Genetic features of cerebrospinal fluid-derived subtype B HIV-1 tat.
  Journal of neurovirology 2012 Choi JY, Hightower GK, Wong JK, Heaton R, Woods S, Grant I, Marcotte TD, Ellis RJ, Letendre SL, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Richman…
• Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012 Ruel TD, Boivin MJ, Boal HE, Bangirana P, Charlebois E, Havlir DV, Rosenthal PJ, Dorsey G, Achan J, Akello C, Kamya MR, Wong JK
• Modification of the Abbott RealTime assay for detection of HIV-1 plasma RNA viral loads less than one copy per milliliter.
  Journal of virological methods 2011 Yukl SA, Li P, Fujimoto K, Lampiris H, Lu CM, Hare CB, Deeks SG, Liegler T, Pandori M, Havlir DV, Wong JK
• The gut mucosal viral reservoir in HIV-infected patients is not the major source of rebound plasma viremia following interruption of highly active antiretroviral therapy.
  Journal of virology 2011 Lerner P, Guadalupe M, Donovan R, Hung J, Flamm J, Prindiville T, Sankaran-Walters S, Syvanen M, Wong JK, George MD, Dandekar S
• Early virologic failure and the development of antiretroviral drug resistance mutations in HIV-infected Ugandan children.
  Journal of acquired immune deficiency syndromes (1999) 2011 Ruel TD, Kamya MR, Li P, Pasutti W, Charlebois ED, Liegler T, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK, Achan J
• HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors.
  Journal of neurovirology 2010 Heaton RK, Franklin DR, Ellis RJ, McCutchan JA, Letendre SL, Leblanc S, Corkran SH, Duarte NA, Clifford DB, Woods SP, Collier AC, Marra CM, Morgello S, Mindt MR, Taylor MJ, Marcotte TD, Atkinson JH, …
• HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study.
  Neurology 2010 Heaton RK, Clifford DB, Franklin DR, Woods SP, Ake C, Vaida F, Ellis RJ, Letendre SL, Marcotte TD, Atkinson JH, Rivera-Mindt M, Vigil OR, Taylor MJ, Collier AC, Marra CM, Gelman BB, McArthur JC, …
• Novel application of Locked Nucleic Acid chemistry for a Taqman assay for measuring diverse human immunodeficiency virus type 1 subtypes.
  Journal of virological methods 2010 Li P, Ruel T, Fujimoto K, Hatano H, Yukl S, Eller LA, Liegler T, Kamya M, Gassasira A, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK
• HIV-subtype A is associated with poorer neuropsychological performance compared with subtype D in antiretroviral therapy-naive Ugandan children.
  AIDS (London, England) 2010 Boivin MJ, Ruel TD, Boal HE, Bangirana P, Cao H, Eller LA, Charlebois E, Havlir DV, Kamya MR, Achan J, Akello C, Wong JK
• In vivo CD8+ T-cell suppression of siv viremia is not mediated by CTL clearance of productively infected cells.
  PLoS pathogens 2010 Wong JK, Strain MC, Porrata R, Reay E, Sankaran-Walters S, Ignacio CC, Russell T, Pillai SK, Looney DJ, Dandekar S
• Dynamics of T cell activation accompanying CD4 recovery in antiretroviral treated HIV-infected Ugandan children.
  Clinical immunology (Orlando, Fla.) 2009 Ruel T, Ssewanyana I, Achan J, Gasasira A, Kamya MR, Kekitiinwa A, Wong JK, Cao H, Havlir D, Charlebois ED
• Unexpected low-level viremia among HIV-infected Ugandan adults with untreated active tuberculosis.
  Journal of acquired immune deficiency syndromes (1999) 2008 Srikantiah P, Wong JK, Liegler T, Walusimbi M, Mayanja-Kizza H, Kayanja HK, Mugerwa RD, Charlebois ED, Boom WH, Whalen CC, Havlir DV
• Persistence of transmitted drug resistance among subjects with primary human immunodeficiency virus infection.
  Journal of virology 2008 Little SJ, Frost SD, Wong JK, Smith DM, Pond SL, Ignacio CC, Parkin NT, Petropoulos CJ, Richman DD
• Inferring HIV transmission dynamics from phylogenetic sequence relationships.
  PLoS medicine 2008 Pilcher CD, Wong JK, Pillai SK
• Turning up the volume on mutational pressure: is more of a good thing always better? (A case study of HIV-1 Vif and APOBEC3).
  Retrovirology 2008 Pillai SK, Wong JK, Barbour JD
• Blood and guts and HIV: preferential HIV persistence in GI mucosa.
  The Journal of infectious diseases 2008 Yukl S, Wong JK
• Long-term persistence of transmitted HIV drug resistance in male genital tract secretions: implications for secondary transmission.
  The Journal of infectious diseases 2007 Smith DM, Wong JK, Shao H, Hightower GK, Mai SH, Moreno JM, Ignacio CC, Frost SD, Richman DD, Little SJ
• HIV drug resistance acquired through superinfection.
  AIDS (London, England) 2005 Smith DM, Wong JK, Hightower GK, Ignacio CC, Koelsch KK, Petropoulos CJ, Richman DD, Little SJ
• Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1.
  The Journal of infectious diseases 2005 Strain MC, Little SJ, Daar ES, Havlir DV, Gunthard HF, Lam RY, Daly OA, Nguyen J, Ignacio CC, Spina CA, Richman DD, Wong JK
• Predictors of residual viremia in HIV-infected patients successfully treated with efavirenz and lamivudine plus either tenofovir or stavudine.
  The Journal of infectious diseases 2005 Havlir DV, Koelsch KK, Strain MC, Margot N, Lu B, Ignacio CC, Miller MD, Wong JK, Gilead 903 Study Team
• Incidence of HIV superinfection following primary infection.
  JAMA 2004 Smith DM, Wong JK, Hightower GK, Ignacio CC, Koelsch KK, Daar ES, Richman DD, Little SJ
• HIV evolution and escape.
  Transactions of the American Clinical and Climatological Association 2004 Richman DD, Little SJ, Smith DM, Wrin T, Petropoulos C, Wong JK
• Productive infection maintains a dynamic steady state of residual viremia in human immunodeficiency virus type 1-infected persons treated with suppressive antiretroviral therapy for five years.
  Journal of virology 2003 Havlir DV, Strain MC, Clerici M, Ignacio C, Trabattoni D, Ferrante P, Wong JK
• Clade B HIV-1 superinfection with wild-type virus after primary infection with drug-resistant clade B virus.
  AIDS (London, England) 2003 Koelsch KK, Smith DM, Little SJ, Ignacio CC, Macaranas TR, Brown AJ, Petropoulos CJ, Richman DD, Wong JK

Show all (100 more) Hide

• Transcriptomic Signatures of Human Immunodeficiency Virus Post-Treatment Control.
  Journal of virology 2022 Wedrychowski A, Martin HA, Li Y, Telwatte S, Kadiyala GN, Melberg M, Etemad B, Connick E, Jacobson JM, Margolis DM, Skiest D, Volberding P, Hecht F, Deeks S, Wong JK, Li JZ, Yukl SA
• Incidence of Severe COVID-19 Illness Following Vaccination and Booster With BNT162b2, mRNA-1273, and Ad26.COV2.S Vaccines.
  JAMA 2022 Kelly JD, Leonard S, Hoggatt KJ, Boscardin WJ, Lum EN, Moss-Vazquez TA, Andino R, Wong JK, Byers A, Bravata DM, Tien PC, Keyhani S
• ABX464 Decreases the Total Human Immunodeficiency Virus (HIV) Reservoir and HIV Transcription Initiation in CD4+ T Cells From Antiretroviral Therapy-Suppressed Individuals Living With HIV.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2022 Moron-Lopez S, Bernal S, Wong JK, Martinez-Picado J, Yukl SA
• Novel assays to investigate the mechanisms of latent infection with HIV-2.
  PloS one 2022 Lu MD, Telwatte S, Kumar N, Ferreira F, Martin HA, Kadiyala GN, Wedrychowski A, Moron-Lopez S, Chen TH, Goecker EA, Coombs RW, Lu CM, Wong JK, Tsibris A, Yukl SA
• Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates With Immune Response.
  The Journal of infectious diseases 2021 Wu G, Zuck P, Goh SL, Milush JM, Vohra P, Wong JK, Somsouk M, Yukl SA, Shacklett BL, Chomont N, Haase AT, Hatano H, Schacker TW, Deeks SG, Hazuda DJ, Hunt PW, Howell BJ
• Tissue-specific differences in HIV DNA levels and mechanisms that govern HIV transcription in blood, gut, genital tract and liver in ART-treated women.
  Journal of the International AIDS Society 2021 Moron-Lopez S, Xie G, Kim P, Siegel DA, Lee S, Wong JK, Price JC, Elnachef N, Greenblatt RM, Tien PC, Roan NR, Yukl SA
• Sudden Cardiac Death and Myocardial Fibrosis, Determined by Autopsy, in Persons with HIV.
  The New England journal of medicine 2021 Tseng ZH, Moffatt E, Kim A, Vittinghoff E, Ursell P, Connolly A, Olgin JE, Wong JK, Hsue PY
• Novel RT-ddPCR assays for measuring the levels of subgenomic and genomic SARS-CoV-2 transcripts.
  Methods (San Diego, Calif.) 2021 Telwatte S, Martin HA, Marczak R, Fozouni P, Vallejo-Gracia A, Kumar GR, Murray V, Lee S, Ott M, Wong JK, Yukl SA
• Novel RT-ddPCR assays for simultaneous quantification of multiple noncoding and coding regions of SARS-CoV-2 RNA.
  Journal of virological methods 2021 Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA
• Saliva as a testing specimen with or without pooling for SARS-CoV-2 detection by multiplex RT-PCR test.
  PloS one 2021 Sun Q, Li J, Ren H, Pastor L, Loginova Y, Madej R, Taylor K, Wong JK, Zhang Z, Zhang A, Lu CM, Sha MY
• Novel RT-ddPCR Assays for determining the transcriptional profile of SARS-CoV-2.
  bioRxiv : the preprint server for biology 2021 Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA
• Human splice factors contribute to latent HIV infection in primary cell models and blood CD4+ T cells from ART-treated individuals.
  PLoS pathogens 2020 Moron-Lopez S, Telwatte S, Sarabia I, Battivelli E, Montano M, Macedo AB, Aran D, Butte AJ, Jones RB, Bosque A, Verdin E, Greene WC, Wong JK, Yukl SA
• Mechanistic differences underlying HIV latency in the gut and blood contribute to differential responses to latency-reversing agents.
  AIDS (London, England) 2020 Telwatte S, Kim P, Chen TH, Milush JM, Somsouk M, Deeks SG, Hunt PW, Wong JK, Yukl SA
• OP 7.6 Tissue-specific differences in the mechanisms that govern HIV latency in blood, liver, gut and genital tract in ART-suppressed women.
  Journal of virus eradication 2019 S. Moron-Lopez, G. Xie, P. Kim, J. Wong, J. Price, N. Elnachef, R. Greenblatt, P. Tien, N. Roan, S. Yukl
• OP 8.3 Intensification of ART with ABX464 decreases the total HIV reservoir and HIV transcription initiation in CD4 T cells from HIV-infected ART-suppressed individuals.
  Journal of virus eradication 2019 S. Moron-Lopez, S. Bernal, J.M. Steens, J.K. Wong, J. Martinez-Picado, S.A. Yukl
• PP 1.3 Single cell analysis reveals molecular signatures of HIV latency in primary cell models.
  Journal of virus eradication 2019 S. Telwatte, M. Montano, R. Resop, E. Battivelli, S. Morón-López, E. Verdin, W. Greene, A. Bosque, J. Wong, S. Yukl
• Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency.
  Retrovirology 2019 Telwatte S, Morón-López S, Aran D, Kim P, Hsieh C, Joshi S, Montano M, Greene WC, Butte AJ, Wong JK, Yukl SA
• 10 Tissue-specific effects of latency-reversing agents on HIV transcriptional blocks in gut and blood.
  Journal of virus eradication 2019 S. Telwatte, P. Kim, T.-H. Chen, J. Milush, M. Somsouk, P. Hunt, S. Deeks, J. Wong, S. Yukl
• 12 In-depth transcription profile comparison of multiple primary cell HIV latency models.
  Journal of virus eradication 2019 S. Moron-Lopez, I. Sarabia, E. Battivelli, M. Montano, S. Telwatte, A. Bosque, E. Verdin, W. Greene, J.K. Wong, S.A. Yukl
• Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate.
  JCI insight 2019 Jiang G, Maverakis E, Cheng MY, Elsheikh MM, Deleage C, Méndez-Lagares G, Shimoda M, Yukl SA, Hartigan-O'Connor DJ, Thompson GR, Estes JD, Wong JK, Dandekar S
• Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals.
  AIDS (London, England) 2019 Moron-Lopez S, Kim P, Søgaard OS, Tolstrup M, Wong JK, Yukl SA
• HIV POST SCD: RATES OF AUTOPSY-DEFINED SUDDEN ARRHYTHMIC DEATH AND CARDIAC FIBROSIS ARE >60% HIGHER IN PERSONS WITH HIV.
  Journal of the American College of Cardiology 2019 Zian H. Tseng, Ellen Moffatt, Annie Bedigian, Joseph K. Wong, Eric Vittinghoff, Andrew Connolly, Jeffrey E. Olgin, Priscilla Hsue
• Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency.
  PLoS pathogens 2018 Telwatte S, Lee S, Somsouk M, Hatano H, Baker C, Kaiser P, Kim P, Chen TH, Milush J, Hunt PW, Deeks SG, Wong JK, Yukl SA
• HIV latency in isolated patient CD4+ T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing.
  Science translational medicine 2018 Yukl SA, Kaiser P, Kim P, Telwatte S, Joshi SK, Vu M, Lampiris H, Wong JK
• HIV latency is reversed by ACSS2-driven histone crotonylation.
  The Journal of clinical investigation 2018 Jiang G, Nguyen D, Archin NM, Yukl SA, Méndez-Lagares G, Tang Y, Elsheikh MM, Thompson GR, Hartigan-O'Connor DJ, Margolis DM, Wong JK, Dandekar S
• Acetylation.
  2018 Anna Cereseto, Yuntao Wu, Jan Davidson-Moncada, Thomas S. Uldrick, Joel Palefsky, Steven A. Yukl, Joseph K. Wong, Shokouh Makvandi-Nejad, Courtney V. Fletcher, Anthony T. Podany, Andrea Calcagno, C. …
• Anatomic Compartments as a Barrier to HIV Cure.
  Encyclopedia of AIDS 2018 Steven A. Yukl, Joseph K. Wong
• OP4.6 Gut and blood differ in mechanisms governing HIV transcription/latency.
  Journal of virus eradication 2017 S. Telwatte, S. Lee, M. Somsouk, H. Hatano, C. Baker, P. Kim, T.-H. Chen, J. Milush, P. Hunt, S. Deeks, J.K. Wong, S.A. Yukl
• Relative efficacy of T cell stimuli as inducers of productive HIV-1 replication in latently infected CD4 lymphocytes from patients on suppressive cART.
  Virology 2017 Beliakova-Bethell N, Hezareh M, Wong JK, Strain MC, Lewinski MK, Richman DD, Spina CA
• Impact of Allogeneic Hematopoietic Stem Cell Transplantation on the HIV Reservoir and Immune Response in 3 HIV-Infected Individuals.
  Journal of acquired immune deficiency syndromes (1999) 2017 Koelsch KK, Rasmussen TA, Hey-Nguyen WJ, Pearson C, Xu Y, Bailey M, Marks KH, Sasson SC, Taylor MS, Tantau R, Obeid S, Milner B, Morrissey O, Pinto AN, Suzuki K, Busch MP, Keating SM, Kaiser P, Yukl S…
• HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for Establishing Viral Replication Early in Infection.
  mBio 2017 Jiang G, Santos Rocha C, Hirao LA, Mendes EA, Tang Y, Thompson GR, Wong JK, Dandekar S
• Assays for precise quantification of total (including short) and elongated HIV-1 transcripts.
  Journal of virological methods 2016 Kaiser P, Joshi SK, Kim P, Li P, Liu H, Rice AP, Wong JK, Yukl SA
• Tissue reservoirs of HIV.
  Current opinion in HIV and AIDS 2016 Wong JK, Yukl SA
• Stimulating the RIG-I pathway to kill cells in the latent HIV reservoir following viral reactivation.
  Nature medicine 2016 Li P, Kaiser P, Lampiris HW, Kim P, Yukl SA, Havlir DV, Greene WC, Wong JK
• Long-term efavirenz use is associated with worse neurocognitive functioning in HIV-infected patients.
  Journal of neurovirology 2015 Ma Q, Vaida F, Wong J, Sanders CA, Kao YT, Croteau D, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, Morgello S, Simpson DM, Heaton RK, Grant I, Letendre SL, CHARTER Group
• Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation.
  PLoS pathogens 2015 Jiang G, Mendes EA, Kaiser P, Wong DP, Tang Y, Cai I, Fenton A, Melcher GP, Hildreth JE, Thompson GR, Wong JK, Dandekar S
• Site-specific differences in T cell frequencies and phenotypes in the blood and gut of HIV-uninfected and ART-treated HIV+ adults.
  PloS one 2015 Yukl SA, Shergill AK, Girling V, Li Q, Killian M, Epling L, Li P, Kaiser P, Haase A, Havlir DV, McQuaid K, Sinclair E, Wong JK
• Efficient deprotection of F-BODIPY derivatives: removal of BF2 using Brønsted acids.
  Beilstein journal of organic chemistry 2015 Yu M, Wong JK, Tang C, Turner P, Todd MH, Rutledge PJ
• Anatomic Compartments as a Barrier to HIV Cure.
  Encyclopedia of AIDS 2015 Steven A. Yukl, Joseph K. Wong
• The Montreal Cognitive Assessment: A Pilot Study of a Brief Screening Tool for Mild and Moderate Cognitive Impairment in HIV-Positive Veterans.
  Journal of the International Association of Providers of AIDS Care 2014 Chartier M, Crouch PC, Tullis V, Catella S, Frawley E, Filanosky C, Carmody T, McQuaid J, Lampiris H, Wong JK
• Role of microRNA modulation in the interferon-α/ribavirin suppression of HIV-1 in vivo.
  PloS one 2014 Abdel-Mohsen M, Deng X, Danesh A, Liegler T, Jacobs ES, Rauch A, Ledergerber B, Norris PJ, Günthard HF, Wong JK, Pillai SK
• Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cδ-NF-κB signaling.
  AIDS (London, England) 2014 Jiang G, Mendes EA, Kaiser P, Sankaran-Walters S, Tang Y, Weber MG, Melcher GP, Thompson GR, Tanuri A, Pianowski LF, Wong JK, Dandekar S
• Exogenous and endogenous hyaluronic acid reduces HIV infection of CD4(+) T cells.
  Immunology and cell biology 2014 Li P, Fujimoto K, Bourguingnon L, Yukl S, Deeks S, Wong JK
• HIV-1 drug resistance in the iPrEx preexposure prophylaxis trial.
  The Journal of infectious diseases 2014 Liegler T, Abdel-Mohsen M, Bentley LG, Atchison R, Schmidt T, Javier J, Mehrotra M, Eden C, Glidden DV, McMahan V, Anderson PL, Li P, Wong JK, Buchbinder S, Guanira JV, Grant RM, iPrEx Study Team
• Advantages of using the QIAshredder instead of restriction digestion to prepare DNA for droplet digital PCR.
  BioTechniques 2014 Yukl SA, Kaiser P, Kim P, Li P, Wong JK
• Discordance between peripheral and colonic markers of inflammation during suppressive ART.
  Journal of acquired immune deficiency syndromes (1999) 2014 Dunham RM, Vujkovic-Cvijin I, Yukl SA, Broadhurst MJ, Loke P, Albright RG, Wong JK, Lederman MM, Somsouk M, Hunt PW, Martin JN, Deeks SG, McCune JM
• A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells.
  AIDS (London, England) 2014 Yukl SA, Sinclair E, Somsouk M, Hunt PW, Epling L, Killian M, Girling V, Li P, Havlir DV, Deeks SG, Wong JK, Hatano H
• Effect of left ventricular dysfunction and viral load on risk of sudden cardiac death in patients with human immunodeficiency virus.
  The American journal of cardiology 2014 Moyers BS, Secemsky EA, Vittinghoff E, Wong JK, Havlir DV, Hsue PY, Tseng ZH
• Multiplexed target detection using DNA-binding dye chemistry in droplet digital PCR.
  Analytical chemistry 2013 McDermott GP, Do D, Litterst CM, Maar D, Hindson CM, Steenblock ER, Legler TC, Jouvenot Y, Marrs SH, Bemis A, Shah P, Wong J, Wang S, Sally D, Javier L, Dinio T, Han C, Brackbill TP, Hodges SP, Ling Y…
• Effects of alpha interferon treatment on intrinsic anti-HIV-1 immunity in vivo.
  Journal of virology 2013 Abdel-Mohsen M, Deng X, Liegler T, Guatelli JC, Salama MS, Ghanem Hel-D, Rauch A, Ledergerber B, Deeks SG, Günthard HF, Wong JK, Pillai SK
• Expression profile of host restriction factors in HIV-1 elite controllers.
  Retrovirology 2013 Abdel-Mohsen M, Raposo RA, Deng X, Li M, Liegler T, Sinclair E, Salama MS, Ghanem Hel-D, Hoh R, Wong JK, David M, Nixon DF, Deeks SG, Pillai SK
• Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient.
  PLoS pathogens 2013 Yukl SA, Boritz E, Busch M, Bentsen C, Chun TW, Douek D, Eisele E, Haase A, Ho YC, Hütter G, Justement JS, Keating S, Lee TH, Li P, Murray D, Palmer S, Pilcher C, Pillai S, Price RW, Rothenberger M, …
• PROLONGED QT INTERVAL PREDICTS SUDDEN CARDIAC DEATH IN HIV-INFECTED INDIVIDUALS.
  Journal of the American College of Cardiology 2013 Brian Moyers, Lauren McGuire, Benjamin Colburn, Diane Havlir, Joseph Wong, Priscilla Hsue, Zian Tseng
• Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies.
  PLoS pathogens 2013 Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, Bosch RJ, Lai J, Chioma S, Emad F, Abdel-Mohsen M, Hoh R, Hecht F, Hunt P, Somsouk M, Wong J, Johnston R, Siliciano RF, Richman DD, O'…
• Role of retroviral restriction factors in the interferon-α-mediated suppression of HIV-1 in vivo.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Pillai SK, Abdel-Mohsen M, Guatelli J, Skasko M, Monto A, Fujimoto K, Yukl S, Greene WC, Kovari H, Rauch A, Fellay J, Battegay M, Hirschel B, Witteck A, Bernasconi E, Ledergerber B, Günthard HF, Wong …
• CD4+ T cell reconstitution, T cell activation, and memory T cell subset composition in blood and gut of HIV-negative and ART-suppressed HIV-positive patients: implications for HIV persistence in the gut.
  Journal of the International AIDS Society 2010 S Yukl, E Sinclair, L Epling, Q Li, A Shergill, K McQuaid, L Duan, B Hare, H Lampiris, A Haase, D Havlir, J Wong
• Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy.
  AIDS (London, England) 2010 Yukl SA, Shergill AK, McQuaid K, Gianella S, Lampiris H, Hare CB, Pandori M, Sinclair E, Günthard HF, Fischer M, Wong JK, Havlir DV
• Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy.
  The Journal of infectious diseases 2010 Yukl SA, Gianella S, Sinclair E, Epling L, Li Q, Duan L, Choi AL, Girling V, Ho T, Li P, Fujimoto K, Lampiris H, Hare CB, Pandori M, Haase AT, Günthard HF, Fischer M, Shergill AK, McQuaid K, Havlir DV…
• NeuroAIDS in Africa.
  Journal of neurovirology 2010 Robertson K, Liner J, Hakim J, Sankalé JL, Grant I, Letendre S, Clifford D, Diop AG, Jaye A, Kanmogne G, Njamnshi A, Langford TD, Weyessa TG, Wood C, Banda M, Hosseinipour M, Sacktor N, Nakasuja N, …
• Association between specific HIV-1 Env traits and virologic control in vivo.
  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2009 Joos B, Rieder P, Fischer M, Kuster H, Rusert P, Trkola A, Pillai SK, Wong JK, Weber R, Günthard HF
• Latently-infected CD4+ T cells are enriched for HIV-1 Tat variants with impaired transactivation activity.
  Virology 2009 Yukl S, Pillai S, Li P, Chang K, Pasutti W, Ahlgren C, Havlir D, Strain M, Günthard H, Richman D, Rice AP, Daar E, Little S, Wong JK
• Pleocytosis is associated with disruption of HIV compartmentalization between blood and cerebral spinal fluid viral populations.
  Virology 2008 Smith DM, Zárate S, Shao H, Pillai SK, Letendre SL, Wong JK, Richman DD, Frost SD, Ellis RJ, HNRC Group
• HIV and antiretroviral therapy in the brain: neuronal injury and repair.
  BMC Proceedings 2008 Ronald Ellis, Dianne Langford, Eliezer Masliah, Igor Grant, Robert Heaton, Joseph Wong, Davey Smith, Scott Letendre, Allen McCutchan
• HIV rebounds from latently infected cells, rather than from continuing low-level replication.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Joos B, Fischer M, Kuster H, Pillai SK, Wong JK, Böni J, Hirschel B, Weber R, Trkola A, Günthard HF, Swiss HIV Cohort Study
• Estimating selection pressures on HIV-1 using phylogenetic likelihood models.
  Statistics in medicine 2008 Kosakovsky Pond SL, Poon AF, Zárate S, Smith DM, Little SJ, Pillai SK, Ellis RJ, Wong JK, Leigh Brown AJ, Richman DD, Frost SD
• HIV RNA suppression among HIV-infected Ugandan children with measles.
  Journal of acquired immune deficiency syndromes (1999) 2008 Ruel TD, Achan J, Gasasira AF, Charlebois ED, Mehbratu T, Rosenthal PJ, Dorsey G, Kamya MR, Kekitiinwa A, Wong J, Havlir DV
• Dynamics of total, linear nonintegrated, and integrated HIV-1 DNA in vivo and in vitro.
  The Journal of infectious diseases 2008 Koelsch KK, Liu L, Haubrich R, May S, Havlir D, Günthard HF, Ignacio CC, Campos-Soto P, Little SJ, Shafer R, Robbins GK, D'Aquila RT, Kawano Y, Young K, Dao P, Spina CA, Richman DD, Wong JK
• Positive in vivo selection of the HIV-1 envelope protein gp120 occurs at surface-exposed regions.
  The Journal of infectious diseases 2007 Joos B, Fischer M, Schweizer A, Kuster H, Böni J, Wong JK, Weber R, Trkola A, Günthard HF
• Covering all the bases: targeting HIV-1 integrase.
  Journal of acquired immune deficiency syndromes (1999) 2006 Wong JK, Lampiris H
• Lack of neutralizing antibody response to HIV-1 predisposes to superinfection.
  Virology 2006 Smith DM, Strain MC, Frost SD, Pillai SK, Wong JK, Wrin T, Liu Y, Petropolous CJ, Daar ES, Little SJ, Richman DD
• Genetic attributes of cerebrospinal fluid-derived HIV-1 env.
  Brain : a journal of neurology 2006 Pillai SK, Pond SL, Liu Y, Good BM, Strain MC, Ellis RJ, Letendre S, Smith DM, Günthard HF, Grant I, Marcotte TD, McCutchan JA, Richman DD, Wong JK
• Low human immunodeficiency virus envelope diversity correlates with low in vitro replication capacity and predicts spontaneous control of plasma viremia after treatment interruptions.
  Journal of virology 2005 Joos B, Trkola A, Fischer M, Kuster H, Rusert P, Leemann C, Böni J, Oxenius A, Price DA, Phillips RE, Wong JK, Hirschel B, Weber R, Günthard HF, Swiss HIV Cohort Study
• Genetic composition of human immunodeficiency virus type 1 in cerebrospinal fluid and blood without treatment and during failing antiretroviral therapy.
  Journal of virology 2005 Strain MC, Letendre S, Pillai SK, Russell T, Ignacio CC, Günthard HF, Good B, Smith DM, Wolinsky SM, Furtado M, Marquie-Beck J, Durelle J, Grant I, Richman DD, Marcotte T, McCutchan JA, Ellis RJ, Wong…
• Semen-specific genetic characteristics of human immunodeficiency virus type 1 env.
  Journal of virology 2005 Pillai SK, Good B, Pond SK, Wong JK, Strain MC, Richman DD, Smith DM
• The prostate as a reservoir for HIV-1.
  AIDS (London, England) 2004 Smith DM, Kingery JD, Wong JK, Ignacio CC, Richman DD, Little SJ
• Attenuated and nonproductive viral transcription in the lymphatic tissue of HIV-1-infected patients receiving potent antiretroviral therapy.
  The Journal of infectious diseases 2004 Fischer M, Joos B, Wong JK, Ott P, Opravil M, Hirschel B, Weber R, Günthard HF, Swiss HIV Cohort Study
• Chapter 34 HIV Drug Susceptibility Testing.
  AIDS and Other Manifestations of HIV Infection 2004 Joseph K. Wong, Davey Smith, Douglas Richman
• Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Strain MC, Günthard HF, Havlir DV, Ignacio CC, Smith DM, Leigh-Brown AJ, Macaranas TR, Lam RY, Daly OA, Fischer M, Opravil M, Levine H, Bacheler L, Spina CA, Richman DD, Wong JK
• Spatiotemporal dynamics of HIV propagation.
  Journal of theoretical biology 2002 Strain MC, Richman DD, Wong JK, Levine H
• Residual cell-associated unspliced HIV-1 RNA in peripheral blood of patients on potent antiretroviral therapy represents intracellular transcripts.
  Antiviral therapy 2002 Fischer M, Wong JK, Russenberger D, Joos B, Opravil M, Hirschel B, Trkola A, Kuster H, Weber R, Günthard HF, Swiss HIV Cohort Study
• Persistent HIV-1-specific cellular responses despite prolonged therapeutic viral suppression.
  AIDS (London, England) 2002 Appay V, Hansasuta P, Sutton J, Schrier RD, Wong JK, Furtado M, Havlir DV, Wolinsky SM, McMichael AJ, Richman DD, Rowland-Jones SL, Spina CA
• Prevalence and predictive value of intermittent viremia with combination hiv therapy.
  JAMA 2001 Havlir DV, Bassett R, Levitan D, Gilbert P, Tebas P, Collier AC, Hirsch MS, Ignacio C, Condra J, Günthard HF, Richman DD, Wong JK
• Evidence for positive selection driving the evolution of HIV-1 env under potent antiviral therapy.
  Virology 2001 Frost SD, Günthard HF, Wong JK, Havlir D, Richman DD, Leigh Brown AJ
• Residual human immunodeficiency virus (HIV) Type 1 RNA and DNA in lymph nodes and HIV RNA in genital secretions and in cerebrospinal fluid after suppression of viremia for 2 years.
  The Journal of infectious diseases 2001 Günthard HF, Havlir DV, Fiscus S, Zhang ZQ, Eron J, Mellors J, Gulick R, Frost SD, Brown AJ, Schleif W, Valentine F, Jonas L, Meibohm A, Ignacio CC, Isaacs R, Gamagami R, Emini E, Haase A, Richman DD,…
• Productive infection of T cells in lymphoid tissues during primary and early human immunodeficiency virus infection.
  The Journal of infectious diseases 2001 Schacker T, Little S, Connick E, Gebhard K, Zhang ZQ, Krieger J, Pryor J, Havlir D, Wong JK, Schooley RT, Richman D, Corey L, Haase AT
• Reduced susceptibility of human immunodeficiency virus type 1 (HIV-1) from patients with primary HIV infection to nonnucleoside reverse transcriptase inhibitors is associated with variation at novel amino acid sites.
  Journal of virology 2000 Brown AJ, Precious HM, Whitcomb JM, Wong JK, Quigg M, Huang W, Daar ES, D'Aquila RT, Keiser PH, Connick E, Hellmann NS, Petropoulos CJ, Richman DD, Little SJ
• Effect of influenza vaccination on viral replication and immune response in persons infected with human immunodeficiency virus receiving potent antiretroviral therapy.
  The Journal of infectious diseases 2000 Günthard HF, Wong JK, Spina CA, Ignacio C, Kwok S, Christopherson C, Hwang J, Haubrich R, Havlir D, Richman DD
• Multiple sites in HIV-1 reverse transcriptase associated with virological response to combination therapy.
  AIDS (London, England) 2000 Precious HM, Günthard HF, Wong JK, D'Aquila RT, Johnson VA, Kuritzkes DR, Richman DD, Leigh Brown AJ
• Rapid accumulation of human immunodeficiency virus (HIV) in lymphatic tissue reservoirs during acute and early HIV infection: implications for timing of antiretroviral therapy.
  The Journal of infectious diseases 2000 Schacker T, Little S, Connick E, Gebhard-Mitchell K, Zhang ZQ, Krieger J, Pryor J, Havlir D, Wong JK, Richman D, Corey L, Haase AT
• Evolution of envelope sequences of human immunodeficiency virus type 1 in cellular reservoirs in the setting of potent antiviral therapy.
  Journal of virology 1999 Günthard HF, Frost SD, Leigh-Brown AJ, Ignacio CC, Kee K, Perelson AS, Spina CA, Havlir DV, Hezareh M, Looney DJ, Richman DD, Wong JK
• Sequence clusters in human immunodeficiency virus type 1 reverse transcriptase are associated with subsequent virological response to antiretroviral therapy.
  The Journal of infectious diseases 1999 Brown AJ, Günthard HF, Wong JK, D'Aquila RT, Johnson VA, Kuritzkes DR, Richman DD
• Higher Selection Pressure from Antiretroviral Drugs in Vivo Results in Increased Evolutionary Distance in HIV-1 pol, Volume 259, Number 1 (1999), pages 154–165.
  Virology 1999 Huldrych F. Günthard, Andrew J. Leigh-Brown, Richard T. D’Aquila, Victoria A. Johnson, Daniel R. Kuritzkes, Douglas D. Richman, Joseph K. Wong
• Higher selection pressure from antiretroviral drugs in vivo results in increased evolutionary distance in HIV-1 pol.
  Virology 1999 Günthard HF, Leigh-Brown AJ, D'Aquila RT, Johnson VA, Kuritzkes DR, Richman DD, Wong JK, D'aquila RT
• Reversibility of the pathological changes in the follicular dendritic cell network with treatment of HIV-1 infection.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Zhang ZQ, Schuler T, Cavert W, Notermans DW, Gebhard K, Henry K, Havlir DV, Günthard HF, Wong JK, Little S, Feinberg MB, Polis MA, Schrager LK, Schacker TW, Richman DD, Corey L, Danner SA, Haase AT
• Comparative performance of high-density oligonucleotide sequencing and dideoxynucleotide sequencing of HIV type 1 pol from clinical samples.
  AIDS research and human retroviruses 1998 Günthard HF, Wong JK, Ignacio CC, Havlir DV, Richman DD
• Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy.
  Journal of virology 1998 Günthard HF, Wong JK, Ignacio CC, Guatelli JC, Riggs NL, Havlir DV, Richman DD
• Recovery of replication-competent HIV despite prolonged suppression of plasma viremia.
  Science (New York, N.Y.) 1997 Wong JK, Hezareh M, Günthard HF, Havlir DV, Ignacio CC, Spina CA, Richman DD
• Reduction of HIV-1 in blood and lymph nodes following potent antiretroviral therapy and the virologic correlates of treatment failure.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Wong JK, Günthard HF, Havlir DV, Zhang ZQ, Haase AT, Ignacio CC, Kwok S, Emini E, Richman DD
• In vivo compartmentalization of human immunodeficiency virus: evidence from the examination of pol sequences from autopsy tissues.
  Journal of virology 1997 Wong JK, Ignacio CC, Torriani F, Havlir D, Fitch NJ, Richman DD
• Streptococcus anginosus-constellatus infection of the sternoclavicular joint.
  The Journal of rheumatology 1984 Hynd RF, Klofkorn RW, Wong JK