Joe Sabatino, MD, PhD
Assistant Professor
Neurology
School of Medicine

Websites

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• Posts on X @jsabatino37 (X.com)

Publications (53)

Top publication keywords:
CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesAntigens, CD20Antibodies, ViralStiff-Person SyndromeAntigens, ViralB-LymphocytesAutoantigensMultiple SclerosisMyelin ProteinsEpstein-Barr Virus InfectionsEncephalomyelitis, Autoimmune, ExperimentalHerpesvirus 4, HumanT-LymphocytesAutoimmunity

• Adenotonsillectomy is associated with increased risk and disease activity in pediatric-onset multiple sclerosis.
  Multiple sclerosis (Houndmills, Basingstoke, England) 2026 Chang G, Nasr Z, Schoeps VA, Virupakshaiah A, Zamvil SS, Moseley CE, Sabatino JJ, Chong J, Graves JS, Waltz M, Rodriguez M, Tillema JM, Chitnis T, Rensel M, Abrams AW, Krupp L, Waldman AT, Mar S, …
• Development of a Diagnostic Autoantibody Assay to a Consensus Motif for the Risk Prediction of Epstein-Barr Virus-Related Multiple Sclerosis.
  Neurology(R) neuroimmunology & neuroinflammation 2026 McCutcheon KM, Bodansky A, Ngo TT, Caspar C, Quintana S, Asaki J, Zhou J, Caillier SJ, Sharathchandra A, Waldrop G, Dandekar R, Zorn K, Tubati A, Gupta S, Sabatino JJ, Cuneo R, Oksenberg J, Wallin MT,…
• Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis.
  Nature immunology 2026 Hayashi F, Mittl K, Dandekar R, Gerdts J, Hassan E, Schubert RD, Oshiro L, Loudermilk R, Greenfield A, Augusto DG, Havton G, Anumarlu S, Surapaneni A, Ramesh A, Tran E, Koshal K, Kizer K, Dreux J, …
• Antigen-specific activation of gut immune cells drives autoimmune neuroinflammation.
  Gut microbes 2025 Siewert LK, Berve K, Pössnecker E, Dyckow J, Zulji A, Baumann R, Munoz-Blazquez A, Krishnamoorthy G, Schreiner D, Sagan S, Nelson C, Sabatino JJ, Nagashima K, Diard M, J Macpherson A, Ganal-Vonarburg …
• Reply to "New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond".
  Annals of neurology 2025 Sabatino JJ, Cree BAC, Hauser SL

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• Sjögren Syndrome Candidate Autoantigen AQP5 Triggers AQP4 CNS Autoimmunity Through Self-Antigen Mimicry.
  Neurology(R) neuroimmunology & neuroinflammation 2025 Moseley CE, Sagan S, Boquett JA, Spencer CM, Hollenbach JA, Sobel RA, Rothbard JB, Steinman L, Sabatino JJ, Zamvil SS
• The changing landscape of multimodality imaging in congenital heart disease: white paper.
  European heart journal. Imaging methods and practice 2025 Di Salvo G, Sabatino J, Babu-Narayan SV, Arvanitaki A, Bonello B, Van De Bruaene A, Cantinotti M, Dos Subira L, Raimondi F, Bharucha T, Enache R, Greil G, Latus H, Bhat M, Valsangiacomo E, Cosyns B, …
• Epstein-Barr Virus in Multiple Sclerosis: Past, Present, and Future.
  Neurology(R) neuroimmunology & neuroinflammation 2025 Wahbeh F, Sabatino JJ
• B-cell antigen presentation in central nervous system autoimmunity.
  Current opinion in immunology 2025 Moseley CE, Sabatino JJ, Zamvil SS
• HLA-A∗03:01 as predictive genetic biomarker for glatiramer acetate treatment response in multiple sclerosis: a retrospective cohort analysis.
  EBioMedicine 2025 Zhang BC, Schneider-Hohendorf T, Elyanow R, Pignolet B, Falk S, Wünsch C, Deffner M, Yusko E, May D, Mattox D, Dawin E, Gerdes LA, Bucciarelli F, Revie L, Antony G, Jarius S, Seidel C, Senel M, …
• New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond.
  Annals of neurology 2025 Sabatino JJ, Cree BAC, Hauser SL
• Durable T cell immunity to COVID-19 vaccines in MS patients on B cell depletion therapy.
  NPJ vaccines 2025 Davis-Porada J, Tozlu C, Aiello C, Apostolidis SA, Bar-Or A, Bove R, Espinoza DA, Ferreira Brito S, Jacobs D, Kakara M, Onomichi K, Ricci A, Sabatino JJ, Walker E, Wherry EJ, Zhang L, Zhu W, Xia Z, De…
• Multiple Sclerosis: A Virus-Induced Gliopathy?
  Neurology(R) neuroimmunology & neuroinflammation 2025 Sabatino JJ, Steinman L
• A single-cell compendium of human cerebrospinal fluid identifies disease-associated immune cell populations.
  The Journal of clinical investigation 2025 Cantoni C, Smirnov RA, Firulyova M, Andhey PS, Bradstreet TR, Esaulova E, Terekhova M, Schwarzkopf EA, Abdalla NM, Kleverov M, Sabatino JJ, Liu K, Schwab N, Meyer Zu Hörste G, Cross AH, Artyomov MN, …
• Antigen specificity of clonally-enriched CD8+ T cells in multiple sclerosis.
  bioRxiv : the preprint server for biology 2024 Mittl K, Hayashi F, Dandekar R, Schubert RD, Gerdts J, Oshiro L, Loudermilk R, Greenfield A, Augusto DG, Ramesh A, Tran E, Koshal K, Kizer K, Dreux J, Cagalingan A, Schustek F, Flood L, Moore T, …
• Molecular mimicry in multisystem inflammatory syndrome in children.
  Nature 2024 Bodansky A, Mettelman RC, Sabatino JJ, Vazquez SE, Chou J, Novak T, Moffitt KL, Miller HS, Kung AF, Rackaityte E, Zamecnik CR, Rajan JV, Kortbawi H, Mandel-Brehm C, Mitchell A, Wang CY, Saxena A, Zorn…
• An autoantibody signature predictive for multiple sclerosis.
  Nature medicine 2024 Zamecnik CR, Sowa GM, Abdelhak A, Dandekar R, Bair RD, Wade KJ, Bartley CM, Kizer K, Augusto DG, Tubati A, Gomez R, Fouassier C, Gerungan C, Caspar CM, Alexander J, Wapniarski AE, Loudermilk RP, …
• A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection.
  Nature 2023 Augusto DG, Murdolo LD, Chatzileontiadou DSM, Sabatino JJ, Yusufali T, Peyser ND, Butcher X, Kizer K, Guthrie K, Murray VW, Pae V, Sarvadhavabhatla S, Beltran F, Gill GS, Lynch KL, Yun C, Maguire CT, …
• T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Sagan SA, Moinfar Z, Moseley CE, Dandekar R, Spencer CM, Verkman AS, Ottersen OP, Sobel RA, Sidney J, Sette A, Anderson MS, Steinman L, Wilson MR, Sabatino JJ, Zamvil SS
• Low protection from breakthrough SARS-CoV-2 infection and mild disease course in ocrelizumab-treated patients with multiple sclerosis after three mRNA vaccine doses.
  Journal of neurology, neurosurgery, and psychiatry 2023 Novak F, Bajwa HM, Coia JE, Nilsson AC, Nielsen C, Holm DK, Østergaard K, Hvidt MVM, Byg KE, Johansen IS, Mittl K, Rowles W, Zamvil SS, Bove R, Sabatino JJ, Sejbaek T
• Remote Observational Research for Multiple Sclerosis: A Natural Experiment.
  Neurology(R) neuroimmunology & neuroinflammation 2022 Bove R, Poole S, Cuneo R, Gupta S, Sabatino J, Harms M, Cooper T, Rowles W, Miller N, Gomez R, Lincoln R, McPolin K, Powers K, Santaniello A, Renschen A, Bevan CJ, Gelfand JM, Goodin DS, Guo CY, Romeo…
• Longitudinal adaptive immune responses following sequential SARS-CoV-2 vaccinations in MS patients on anti-CD20 therapies and sphingosine-1-phosphate receptor modulators.
  Multiple sclerosis and related disorders 2022 Sabatino JJ, Mittl K, Rowles W, Zamecnik CR, Loudermilk RP, Gerungan C, Spencer CM, Sagan SA, Alexander J, Mcpolin K, Chen P, Deshpande C, Wyse K, Maiese EM, Wilson MR, Zamvil SS, Bove R
• A common allele of HLA mediates asymptomatic SARS-CoV-2 infection.
  medRxiv : the preprint server for health sciences 2022 Augusto DG, Yusufali T, Sabatino JJ, Peyser ND, Murdolo LD, Butcher X, Murray V, Pae V, Sarvadhavabhatla S, Beltran F, Gill G, Lynch K, Yun C, Maguire C, Peluso MJ, Hoh R, Henrich TJ, Deeks SG, …
• Evolution of echocardiographic and cardiac magnetic resonance imaging abnormalities during follow-up in patients with multisystem inflammatory syndrome in children.
  European heart journal. Cardiovascular Imaging 2022 Sirico D, Basso A, Sabatino J, Reffo E, Cavaliere A, Biffanti R, Cerutti A, Castaldi B, Zulian F, Da Dalt L, Di Salvo G
• SARS-CoV-2 Variant Exposures Elicit Antibody Responses With Differential Cross-Neutralization of Established and Emerging Strains Including Delta and Omicron.
  The Journal of infectious diseases 2022 Laurie MT, Liu J, Sunshine S, Peng J, Black D, Mitchell AM, Mann SA, Pilarowski G, Zorn KC, Rubio L, Bravo S, Marquez C, Sabatino JJ, Mittl K, Petersen M, Havlir D, DeRisi J
• Persistently reduced humoral and sustained cellular immune response from first to third SARS-CoV-2 mRNA vaccination in anti-CD20-treated multiple sclerosis patients.
  Multiple sclerosis and related disorders 2022 Bajwa HM, Novak F, Nilsson AC, Nielsen C, Holm DK, Østergaard K, Witt AH, Byg KE, Johansen IS, Mittl K, Rowles W, Zamvil SS, Bove R, Sabatino JJ, Sejbaek T
• Multiple sclerosis therapies differentially affect SARS-CoV-2 vaccine-induced antibody and T cell immunity and function.
  JCI insight 2022 Sabatino JJ, Mittl K, Rowles WM, McPolin K, Rajan JV, Laurie MT, Zamecnik CR, Dandekar R, Alvarenga BD, Loudermilk RP, Gerungan C, Spencer CM, Sagan SA, Augusto DG, Alexander JR, DeRisi JL, Hollenbach…
• SARS-CoV-2 variant exposures elicit antibody responses with differential cross-neutralization of established and emerging strains including Delta and Omicron.
  medRxiv : the preprint server for health sciences 2021 Laurie MT, Liu J, Sunshine S, Peng J, Black D, Mitchell AM, Mann SA, Pilarowski G, Zorn KC, Rubio L, Bravo S, Marquez C, Sabatino JJ, Mittl K, Petersen M, Havlir D, DeRisi J
• Impact of multiple sclerosis disease-modifying therapies on SARS-CoV-2 vaccine-induced antibody and T cell immunity.
  medRxiv : the preprint server for health sciences 2021 Sabatino JJ, Mittl K, Rowles W, Mcpolin K, Rajan JV, Zamecnik CR, Dandekar R, Alvarenga BD, Loudermilk RP, Gerungan C, Spencer CM, Sagan SA, Augusto DG, Alexander J, Hollenbach JA, Wilson MR, Zamvil …
• Humoral immune response following SARS-CoV-2 mRNA vaccination concomitant to anti-CD20 therapy in multiple sclerosis.
  Multiple sclerosis and related disorders 2021 Novak F, Nilsson AC, Nielsen C, Holm DK, Østergaard K, Bystrup A, Byg KE, Johansen IS, Mittl K, Rowles W, Mcpolin K, Spencer C, Sagan S, Gerungan C, Wilson MR, Zamvil SS, Bove R, Sabatino JJ, Sejbaek …
• A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Ramesh A, Schubert RD, Greenfield AL, Dandekar R, Loudermilk R, Sabatino JJ, Koelzer MT, Tran EB, Koshal K, Kim K, Pröbstel AK, Banerji D, University of California, San Francisco MS-EPIC Team, Guo CY,…
• Publisher Correction: B cells in autoimmune and neurodegenerative central nervous system diseases.
  Nature reviews. Neuroscience 2020 Sabatino JJ, Pröbstel AK, Zamvil SS
• Anti-CD20 therapy depletes activated myelin-specific CD8+ T cells in multiple sclerosis.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Sabatino JJ, Wilson MR, Calabresi PA, Hauser SL, Schneck JP, Zamvil SS
• B cells in autoimmune and neurodegenerative central nervous system diseases.
  Nature reviews. Neuroscience 2019 Sabatino JJ, Pröbstel AK, Zamvil SS
• B-Cell Therapies in Multiple Sclerosis.
  Cold Spring Harbor perspectives in medicine 2019 Sabatino JJ, Zamvil SS, Hauser SL
• T cells take aim at a ubiquitous autoantigen in multiple sclerosis.
  Science translational medicine 2018 Sabatino JJ, Zamvil SS
• NFM Cross-Reactivity to MOG Does Not Expand a Critical Threshold Level of High-Affinity T Cells Necessary for Onset of Demyelinating Disease.
  Journal of immunology (Baltimore, Md. : 1950) 2017 Blanchfield L, Sabatino JJ, Lawrence L, Evavold BD
• Aryl hydrocarbon receptor activity may serve as a surrogate marker for MS disease activity.
  Neurology(R) neuroimmunology & neuroinflammation 2017 Sabatino JJ, Zamvil SS
• Acute liver injury in a Glatopa-treated patient with MS.
  Neurology(R) neuroimmunology & neuroinflammation 2017 Sabatino JJ, Mehta NJ, Kakar S, Zamvil SS, Cree BAC
• Stiff person syndrome masquerading as multiple sclerosis.
  Journal of the neurological sciences 2016 Sabatino JJ, Newsome SD
• Teaching Video NeuroImages: The hopping lid twitch in myasthenia gravis.
  Neurology 2016 Quiroga AC, Sabatino JJ, Zee DS, Gold DR
• Unique invariant CD8(+) T cell population persists in MS.
  Neurology(R) neuroimmunology & neuroinflammation 2015 Sabatino JJ, Zamvil SS
• A rare case of hyponatremia from a hypothalamic lesion in a patient with multiple sclerosis.
  Multiple sclerosis (Houndmills, Basingstoke, England) 2014 Sabatino JJ, Werner JK, Newsome SD
• Low 2-dimensional CD4 T cell receptor affinity for myelin sets in motion delayed response kinetics.
  PloS one 2012 Rosenthal KM, Edwards LJ, Sabatino JJ, Hood JD, Wasserman HA, Zhu C, Evavold BD
• Self-reactive human CD4 T cell clones form unusual immunological synapses.
  The Journal of experimental medicine 2012 Schubert DA, Gordo S, Sabatino JJ, Vardhana S, Gagnon E, Sethi DK, Seth NP, Choudhuri K, Reijonen H, Nepom GT, Evavold BD, Dustin ML, Wucherpfennig KW
• High prevalence of low affinity peptide-MHC II tetramer-negative effectors during polyclonal CD4+ T cell responses.
  The Journal of experimental medicine 2011 Sabatino JJ, Huang J, Zhu C, Evavold BD
• Manipulating antigenic ligand strength to selectively target myelin-reactive CD4+ T cells in EAE.
  Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2009 Sabatino JJ, Rosenthal KM, Evavold BD
• Loss of IFN-gamma enables the expansion of autoreactive CD4+ T cells to induce experimental autoimmune encephalomyelitis by a nonencephalitogenic myelin variant antigen.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Sabatino JJ, Shires J, Altman JD, Ford ML, Evavold BD
• Targeted mast cell silencing protects against joint destruction and angiogenesis in experimental arthritis in mice.
  Arthritis and rheumatism 2007 Kneilling M, Hültner L, Pichler BJ, Mailhammer R, Morawietz L, Solomon S, Eichner M, Sabatino J, Biedermann T, Krenn V, Weber WA, Illges H, Haubner R, Röcken M
• Mast cells are required for optimal autoreactive T cell responses in a murine model of multiple sclerosis.
  European journal of immunology 2005 Gregory GD, Robbie-Ryan M, Secor VH, Sabatino JJ, Brown MA
• Availability of combination therapy for HIV: effects on sexual risk taking in a sample of high-risk gay and bisexual men.
  AIDS care 2003 Dilley JW, Woods WJ, Sabatino J, Rinaldi J, Lihatsh T, McFarland W
• HIV testing in gay sex clubs.
  International journal of STD & AIDS 2000 Woods WJ, Sabatino J, Bauer PL, Adler B, Dilley JW, Binson D
• Name-based reporting of HIV-positive test results as a deterrent to testing.
  American journal of public health 1999 Woods WJ, Dilley JW, Lihatsh T, Sabatino J, Adler B, Rinaldi J