Joseph Blecha, MS
Specialist
Radiology
School of Medicine

Publications (48)

Top publication keywords:
Receptors, Opioid, muGlutamate Carboxypeptidase IIPositron-Emission TomographyFluorine RadioisotopesTissue DistributionFentanylAmidesCarbon RadioisotopesParaoxonChemistry Techniques, SyntheticAcetylcholinesteraseSarinRadioactive TracersMethioninePhosphoric Acids

• Bioorthogonal Radiolabeling of Azide-Modified Bacteria Using [18F]FB-sulfo-DBCO.
  Bioconjugate chemistry 2024 Alanizi AA, Sorlin AM, Parker MFL, López-Álvarez M, Qin H, Lee SH, Blecha J, Rosenberg OS, Engel J, Ohliger MA, Flavell RR, Wilson DM
• Peptidoglycan-Targeted [18F]3,3,3-Trifluoro-d-alanine Tracer for Imaging Bacterial Infection.
  JACS Au 2024 Sorlin AM, López-Álvarez M, Biboy J, Gray J, Rabbitt SJ, Rahim JU, Lee SH, Bobba KN, Blecha J, Parker MFL, Flavell RR, Engel J, Ohliger M, Vollmer W, Wilson DM
• [11C]Paraoxon: Radiosynthesis, Biodistribution and In Vivo Positron Emission Tomography Imaging in Rat.
  The Journal of pharmacology and experimental therapeutics 2024 Hayes TR, Chao CK, Blecha JE, Huynh TL, VanBrocklin HF, Zinn KR, Gerdes JM, Thompson CM
• Imaging the Bacterial Cell Wall Using N-Acetyl Muramic Acid-Derived Positron Emission Tomography Radiotracers.
  ACS sensors 2023 Lee SH, Kim JM, López-Álvarez M, Wang C, Sorlin AM, Bobba KN, Pichardo-González PA, Blecha J, Seo Y, Flavell RR, Engel J, Ohliger MA, Wilson DM
• Evaluating the Performance of Pathogen-Targeted Positron Emission Tomography Radiotracers in a Rat Model of Vertebral Discitis-Osteomyelitis.
  The Journal of infectious diseases 2023 Parker MFL, López-Álvarez M, Alanizi AA, Luu JM, Polvoy I, Sorlin AM, Qin H, Lee S, Rabbitt SJ, Pichardo-González PA, Ordonez AA, Blecha J, Rosenberg OS, Flavell RR, Engel J, Jain SK, Ohliger MA, …

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• Chemoenzymatic Syntheses of Fluorine-18-Labeled Disaccharides from [18F] FDG Yield Potent Sensors of Living Bacteria In Vivo.
  Journal of the American Chemical Society 2023 Sorlin AM, López-Álvarez M, Rabbitt SJ, Alanizi AA, Shuere R, Bobba KN, Blecha J, Sakhamuri S, Evans MJ, Bayles KW, Flavell RR, Rosenberg OS, Sriram R, Desmet T, Nidetzky B, Engel J, Ohliger MA, …
• Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism.
  Cell metabolism 2023 Midha AD, Zhou Y, Queliconi BB, Barrios AM, Haribowo AG, Chew BTL, Fong COY, Blecha JE, VanBrocklin H, Seo Y, Jain IH
• P-65 Cyclic [68Ga] and [18F]AlF-labeled peptides for specific detection of human angiotensin-converting enzyme 2.
  Nuclear Medicine and Biology 2022 David Wilson, Anju Anju, Matthew Parker, Niranjan Meher, Joseph Blecha, Oren Rosenberg, Michael Ohliger, Robert Flavell
• Antigen-Dependent Inducible T-Cell Reporter System for PET Imaging of Breast Cancer and Glioblastoma.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2022 Shin J, Parker MFL, Zhu I, Alanizi A, Rodriguez CI, Liu R, Watchmaker PB, Kalita M, Blecha J, Luu J, Wright B, Lapi SE, Flavell RR, Okada H, Tlsty TD, Roybal KT, Wilson DM
• Imaging joint infections using D-methyl-11C-methionine PET/MRI: initial experience in humans.
  European journal of nuclear medicine and molecular imaging 2022 Polvoy I, Seo Y, Parker M, Stewart M, Siddiqua K, Manacsa HS, Ravanfar V, Blecha J, Hope TA, Vanbrocklin H, Flavell RR, Barry J, Hansen E, Villanueva-Meyer JE, Engel J, Rosenberg OS, Wilson DM, …
• P-162 Electronic cigarette aerosol deposition of [11C]nicotine in human subjects: radiosynthesis and vaping apparatus development.
  Nuclear Medicine and Biology 2022 Henry VanBrocklin, Joseph Blecha, Robin Ippisch, Christopher Havel, Gideon St. Helen, Spencer Behr
• Evaluating Radioactive Analogs of Doxorubicin to Quantify ChemoFilter Binding and Whole-Body Positron Emission Tomography/Magnetic Resonance Imaging for Drug Biodistribution.
  Journal of vascular and interventional radiology : JVIR 2022 Kumar P, Yee C, Blecha JE, Hayes TR, Kilbride BF, Stillson C, Losey AD, Mastria E, Jordan CD, Huynh TL, Moore T, Wilson MW, VanBrocklin HF, Hetts SW
• Longitudinal Imaging of T Cells and Inflammatory Demyelination in a Preclinical Model of Multiple Sclerosis Using 18F-FAraG PET and MRI.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2021 Guglielmetti C, Levi J, Huynh TL, Tiret B, Blecha J, Tang R, VanBrocklin H, Chaumeil MM
• Cyclic 68Ga-Labeled Peptides for Specific Detection of Human Angiotensin-Converting Enzyme 2.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2021 Parker MFL, Blecha J, Rosenberg O, Ohliger M, Flavell RR, Wilson DM
• Biological Distribution and Metabolic Profiles of Carbon-11 and Fluorine-18 Tracers of VX- and Sarin-Analogs in Sprague-Dawley Rats.
  Chemical research in toxicology 2020 Hayes TR, Chao CK, Blecha JE, Huynh TL, Zinn KR, Thompson CM, Gerdes JM, VanBrocklin HF
• Dose Formulation, Biodistribution and PET Imaging Studies of a First-In-Class Fluorine-18 Organophosphorus Cholinesterase Inhibitor Tracer in Rat.
  Current Chemical Biology 2020 Kiel D. Neumann, Joseph E. Blecha, Chih-Kai Chao, Tony Huynh, Kurt R. Zinn, Henry F. VanBrocklin, Charles M. Thompson, John M. Gerdes
• The Synthesis and Structural Requirements for Measuring Glucocorticoid Receptor Expression In Vivo with (±)-11C-YJH08 PET.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2020 Huang Y, Zhao N, Wang YH, Truillet C, Wei J, Parker MFL, Blecha JE, Drake CR, VanBrocklin HF, Garrido-Ruiz D, Jacobson MP, Aggarwal R, Behr SC, Flavell RR, Wilson DM, Seo Y, Evans MJ
• Positron emission tomography evaluation of oxime countermeasures in live rats using the tracer O-(2-[18 F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate [18 F]-VXS.
  Annals of the New York Academy of Sciences 2020 Hayes TR, Blecha JE, Chao CK, Huynh TL, VanBrocklin HF, Zinn KR, Taylor PW, Gerdes JM, Thompson CM
• A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography.
  ACS chemical biology 2020 Huang Y, Zhao N, Wang YH, Truillet C, Wei J, Blecha JE, VanBrocklin HF, Seo Y, Sayeed M, Feldman BJ, Aggarwal R, Behr SC, Shao H, Wilson DM, Villanueva-Meyer JE, Gestwicki JE, Evans MJ
• Arabinofuranose-derived positron-emission tomography radiotracers for detection of pathogenic microorganisms.
  Journal of labelled compounds & radiopharmaceuticals 2020 Kalita M, Parker MFL, Luu JM, Stewart MN, Blecha JE, VanBrocklin HF, Evans MJ, Flavell RR, Rosenberg OS, Ohliger MA, Wilson DM
• PET/CT Imaging of Human TNFα Using [89Zr]Certolizumab Pegol in a Transgenic Preclinical Model of Rheumatoid Arthritis.
  Molecular imaging and biology 2020 Beckford-Vera DR, Gonzalez-Junca A, Janneck JS, Huynh TL, Blecha JE, Seo Y, Li X, VanBrocklin HF, Franc BL
• High Enantiomeric Excess In-Loop Synthesis of d-[methyl-11C]Methionine for Use as a Diagnostic Positron Emission Tomography Radiotracer in Bacterial Infection.
  ACS infectious diseases 2019 Stewart MN, Parker MFL, Jivan S, Luu JM, Huynh TL, Schulte B, Seo Y, Blecha JE, Villanueva-Meyer JE, Flavell RR, VanBrocklin HF, Ohliger MA, Rosenberg O, Wilson DM
• Synthesis and Initial Biological Evaluation of Boron-Containing Prostate-Specific Membrane Antigen Ligands for Treatment of Prostate Cancer Using Boron Neutron Capture Therapy.
  Molecular pharmaceutics 2019 Wang S, Blaha C, Santos R, Huynh T, Hayes TR, Beckford-Vera DR, Blecha JE, Hong AS, Fogarty M, Hope TA, Raleigh DR, Wilson DM, Evans MJ, VanBrocklin HF, Ozawa T, Flavell RR
• OP#41 Immuno-PET imaging of human tumor necrosis factor alpha in a transgenic mouse model of rheumatoid arthritis.
  Nuclear Medicine and Biology 2019 V. Beckford, C. Fu, J. Janneck, T. Huynh, J. Blecha, X. Li, B. Franc, H. Vanbrocklin
• Divergent synthesis of organophosphate [11C]VX- and [11C]Sarin-surrogates from a common set of starting materials.
  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2019 Hayes TR, Blecha JE, Thompson CM, Gerdes JM, VanBrocklin HF
• Imaging of Activated T Cells as an Early Predictor of Immune Response to Anti-PD-1 Therapy.
  Cancer research 2019 Levi J, Lam T, Goth SR, Yaghoubi S, Bates J, Ren G, Jivan S, Huynh TL, Blecha JE, Khattri R, Schmidt KF, Jennings D, VanBrocklin H
• Phase I Study of CTT1057, an 18F-Labeled Imaging Agent with Phosphoramidate Core Targeting Prostate-Specific Membrane Antigen in Prostate Cancer.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2018 Behr SC, Aggarwal R, VanBrocklin HF, Flavell RR, Gao K, Small EJ, Blecha J, Jivan S, Hope TA, Simko JP, Kurhanewicz J, Noworolski SM, Korn NJ, De Los Santos R, Cooperberg MR, Carroll PR, Nguyen HG, …
• Radiosynthesis of O-(1-[18 F]fluoropropan-2-yl)-O-(4-nitrophenyl)methylphosphonate: A novel PET tracer surrogate of sarin.
  Journal of labelled compounds & radiopharmaceuticals 2018 Hayes TR, Thompson CM, Blecha JE, Gerdes JM, VanBrocklin HF
• Radiosynthesis, ex Vivo Biodistribution, and in Vivo Positron Emission Tomography Imaging Evaluations of [11C]2-Pyridinealdoxime Methiodide ([11C]2-PAM): A First-In-Class Antidote Tracer for Organophosphate Intoxication.
  ACS chemical neuroscience 2018 Neumann KD, Blecha JE, Hayes TR, Huynh T, Chao CK, Guilloteau N, Zinn KR, VanBrocklin HF, Thompson CM, Gerdes JM
• Late-stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI.
  Chemical communications (Cambridge, England) 2018 Taglang C, Korenchan DE, von Morze C, Yu J, Najac C, Wang S, Blecha JE, Subramaniam S, Bok R, VanBrocklin HF, Vigneron DB, Ronen SM, Sriram R, Kurhanewicz J, Wilson DM, Flavell RR
• [11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism.
  ACS infectious diseases 2018 Mutch CA, Ordonez AA, Qin H, Parker M, Bambarger LE, Villanueva-Meyer JE, Blecha J, Carroll V, Taglang C, Flavell R, Sriram R, VanBrocklin H, Rosenberg O, Ohliger MA, Jain SK, Neumann KD, Wilson DM
• Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers.
  Scientific reports 2017 Neumann KD, Villanueva-Meyer JE, Mutch CA, Flavell RR, Blecha JE, Kwak T, Sriram R, VanBrocklin HF, Rosenberg OS, Ohliger MA, Wilson DM
• First-in-human phase 1 PET study of CTT1057, a novel 18 F-labeled imaging agent targeting prostate specific membrane antigen (PSMA) in prostate cancer.
  Journal of Clinical Oncology 2017 Rahul Raj Aggarwal, Spencer Behr, Youngho Seo, Kenneth Gao, Vahid Rahanfar, Jim Slater, Joseph Blecha, Beatrice Langton-Webster, Clifford Berkman, Henry Vanbrocklin
• An improved radiosynthesis of O-(2-[18 F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate: A first-in-class cholinesterase PET tracer.
  Journal of labelled compounds & radiopharmaceuticals 2017 Neumann KD, Thompson CM, Blecha JE, Gerdes JM, VanBrocklin HF
• An updated synthesis of [11 C]carfentanil for positron emission tomography (PET) imaging of the μ-opioid receptor.
  Journal of labelled compounds & radiopharmaceuticals 2017 Blecha JE, Henderson BD, Hockley BG, VanBrocklin HF, Zubieta JK, DaSilva AF, Kilbourn MR, Koeppe RA, Scott PJH, Shao X
• In Vivo PET Imaging of the Activated Immune Environment in a Small Animal Model of Inflammatory Arthritis.
  Molecular imaging 2017 Franc BL, Goth S, MacKenzie J, Li X, Blecha J, Lam T, Jivan S, Hawkins RA, VanBrocklin H
• Structure-Activity Relationship of (18)F-Labeled Phosphoramidate Peptidomimetic Prostate-Specific Membrane Antigen (PSMA)-Targeted Inhibitor Analogues for PET Imaging of Prostate Cancer.
  Journal of medicinal chemistry 2016 Dannoon S, Ganguly T, Cahaya H, Geruntho JJ, Galliher MS, Beyer SK, Choy CJ, Hopkins MR, Regan M, Blecha JE, Skultetyova L, Drake CR, Jivan S, Barinka C, Jones EF, Berkman CE, VanBrocklin HF
• [(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice.
  Molecular imaging and biology 2016 Li L, Che L, Wang C, Blecha JE, Li X, VanBrocklin HF, Calvisi DF, Puchowicz M, Chen X, Seo Y
• Ictal lack of binding to brain parenchyma suggests integrity of the blood-brain barrier for 11C-dihydroergotamine during glyceryl trinitrate-induced migraine.
  Brain : a journal of neurology 2016 Schankin CJ, Maniyar FH, Seo Y, Kori S, Eller M, Chou DE, Blecha J, Murphy ST, Hawkins RA, Sprenger T, VanBrocklin HF, Goadsby PJ
• Caged [(18)F]FDG Glycosylamines for Imaging Acidic Tumor Microenvironments Using Positron Emission Tomography.
  Bioconjugate chemistry 2015 Flavell RR, Truillet C, Regan MK, Ganguly T, Blecha JE, Kurhanewicz J, VanBrocklin HF, Keshari KR, Chang CJ, Evans MJ, Wilson DM
• NIMG-45REAL-TIME PET IMAGING DEMONSTRATES TUMOR ACCUMULATION AND OXYGENATION BY OMX-4.80P, AN OXYGEN CARRIER ENGINEERED FOR THE TREATMENT OF GLIOBLASTOMA.
  Neuro-Oncology 2015 Laura Serwer, Natacha Le Moan, Melanie Regan, Joseph Blecha, Andrew Davis, Kevin Tanaka, Tim Keating, Jamie Romero, Philberta Leung, Tina Davis, Catherine Bedard, Sarah Ng, Feng Yan, Raquel Santos, …
• Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI.
  Chemical communications (Cambridge, England) 2015 Flavell RR, von Morze C, Blecha JE, Korenchan DE, Van Criekinge M, Sriram R, Gordon JW, Chen HY, Subramaniam S, Bok RA, Wang ZJ, Vigneron DB, Larson PE, Kurhanewicz J, Wilson DM
• A high-affinity [(18)F]-labeled phosphoramidate peptidomimetic PSMA-targeted inhibitor for PET imaging of prostate cancer.
  Nuclear medicine and biology 2015 Ganguly T, Dannoon S, Hopkins MR, Murphy S, Cahaya H, Blecha JE, Jivan S, Drake CR, Barinka C, Jones EF, VanBrocklin HF, Berkman CE
• EHMTI-0125. Studying the permeability of the blood-brain barrier during migraine attacks using [11C]-dihydroergotamine.
  The Journal of Headache and Pain 2014 C Schankin, F Maniyar, Y Seo, S Kori, M Eller, J Blecha, S Murphy, T Sprenger, H VanBrocklin, P Goadsby
• A boronate-caged [¹⁸F]FLT probe for hydrogen peroxide detection using positron emission tomography.
  Journal of the American Chemical Society 2014 Carroll V, Michel BW, Blecha J, VanBrocklin H, Keshari K, Wilson D, Chang CJ
• Ictal Lack of Binding of [ 11 C]-Dihydroergotamine to Brain Parenchyma Suggests That the Blood-Brain Barrier Remains Intact during Migraine Attacks (S32.002).
  Neurology 2014 Christoph Schankin, Farooq Maniyar, Youngho Seo, Shashidar Kori, Michael Eller, Joseph Blecha, Stephanie Murphy, Till Sprenger, Henry VanBrocklin, Peter Goadsby
• Inhibition of IGF-1R and lipoxygenase by nordihydroguaiaretic acid (NDGA) analogs.
  Bioorganic & medicinal chemistry letters 2007 Blecha JE, Anderson MO, Chow JM, Guevarra CC, Pender C, Penaranda C, Zavodovskaya M, Youngren JF, Berkman CE
• Stereoselective inhibition of glutamate carboxypeptidase by organophosphorus derivatives of glutamic acid.
  Bioorganic & medicinal chemistry 2004 Mallari JP, Choy CJ, Hu Y, Martinez AR, Hosaka M, Toriyabe Y, Maung J, Blecha JE, Pavkovic SF, Berkman CE