Jose Gomez-Arroyo, MD, PhD
Assistant Professor
Medicine
School of Medicine

My lab integrates human genomics with single-cell and spatial transcriptomics to develop and validate experimental/pre-clinical models of PAH. We use these approaches to understand how developmental transcription factors maintain endothelial cell identity and how disruption of these programs contributes to vascular remodeling. Our clinical research complements this work by identifying biomarkers that improve disease detection and risk assessment. We are expanding our efforts to define how rare genetic variants influence disease susceptibility, investigate their functional effects using patient-derived vascular organoids, and develop strategies to restore endothelial function.

• FOXF1 promotes tumor vessel normalization and prevents lung cancer progression through FZD4.
  EMBO molecular medicine 2024 Bian F, Goda C, Wang G, Lan YW, Deng Z, Gao W, Acharya A, Reza AA, Gomez-Arroyo J, Merjaneh N, Ren X, Goveia J, Carmeliet P, Kalinichenko VV, Kalin TV
• Hypoxia represses FOXF1 in lung endothelial cells through HIF-1a.
  Frontiers in physiology 2024 Acharya A, Bian F, Gomez-Arroyo J, Wagner KA, Kalinichenko VV, Kalin TV
• Corrigendum: Improving anti-tumor efficacy of low-dose Vincristine in rhabdomyosarcoma via the combination therapy with FOXM1 inhibitor RCM1.
  Frontiers in oncology 2023 Donovan J, Deng Z, Bian F, Shukla S, Gomez-Arroyo J, Shi D, Kalinichenko VV, Kalin TV
• Demonstration of Safety in Wild Type Mice of npFOXF1, a Novel Nanoparticle-Based Gene Therapy for Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins.
  Biologics : targets & therapy 2023 Kohram F, Deng Z, Zhang Y, Al Reza AA, Li E, Kolesnichenko OA, Shukla S, Ustiyan V, Gomez-Arroyo J, Acharya A, Shi D, Kalinichenko VV, Kenny AP
• Improving anti-tumor efficacy of low-dose Vincristine in rhabdomyosarcoma via the combination therapy with FOXM1 inhibitor RCM1.
  Frontiers in oncology 2023 Donovan J, Deng Z, Bian F, Shukla S, Gomez-Arroyo J, Shi D, Kalinichenko VV, Kalin TV
• Distinct Platelet Ribonucleic Acid Signatures in Patients with Pulmonary Hypertension.
  Annals of the American Thoracic Society 2022 Smits AJ, Arkani M, In 't Veld SGJG, Huis In 't Veld AE, Sol N, Groeneveldt JA, Botros L, Braams NJ, Jansen SMA, Ramaker J, Zwaan K, Post E, Nossent EJ, Boonstra A, de Man FS, Vonk Noordegraaf A, …
• Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia.
  Circulation 2021 Sun F, Wang G, Pradhan A, Xu K, Gomez-Arroyo J, Zhang Y, Kalin GT, Deng Z, Vagnozzi RJ, He H, Dunn AW, Wang Y, York AJ, Hegde RS, Woods JC, Kalin TV, Molkentin JD, Kalinichenko VV
• Resistin-Like Molecule a Dysregulates Cardiac Bioenergetics in Neonatal Rat Cardiomyocytes.
  Frontiers in cardiovascular medicine 2021 Tao B, Kumar S, Gomez-Arroyo J, Fan C, Zhang A, Skinner J, Hunter E, Yamaji-Kegan K, Samad I, Hillel AT, Lin Q, Zhai W, Gao WD, Johns RA
• Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial.
  JAMA 2020 Self WH, Semler MW, Leither LM, Casey JD, Angus DC, Brower RG, Chang SY, Collins SP, Eppensteiner JC, Filbin MR, Files DC, Gibbs KW, Ginde AA, Gong MN, Harrell FE, Hayden DL, Hough CL, Johnson NJ, …
• SCUBE Diving: Biomarker Discovery for Pulmonary Hypertension From Bench to Bedside.
  JACC. Basic to translational science 2020 Gomez-Arroyo J, Voelkel NF, Abbate A
• Angiotensin converting enzyme 2 and angiotensin (1-7) axis in pulmonary arterial hypertension.
  The European respiratory journal 2020 Sandoval J, Del Valle-Mondragón L, Masso F, Zayas N, Pulido T, Teijeiro R, Gonzalez-Pacheco H, Olmedo-Ocampo R, Sisniega C, Paez-Arenas A, Pastelin-Hernandez G, Gomez-Arroyo J, Voelkel NF
• HIMF (Hypoxia-Induced Mitogenic Factor) Signaling Mediates the HMGB1 (High Mobility Group Box 1)-Dependent Endothelial and Smooth Muscle Cell Crosstalk in Pulmonary Hypertension.
  Arteriosclerosis, thrombosis, and vascular biology 2019 Lin Q, Fan C, Gomez-Arroyo J, Van Raemdonck K, Meuchel LW, Skinner JT, Everett AD, Fang X, Macdonald AA, Yamaji-Kegan K, Johns RA
• Consequences of chronic frequent premature atrial contractions: Association with cardiac arrhythmias and cardiac structural changes.
  Journal of cardiovascular electrophysiology 2019 Gunda S, Akyeampong D, Gomez-Arroyo J, Jovin DG, Kowlgi NG, Kaszala K, Tan AY, Koneru JN, Kron J, Ellenbogen KA, Huizar JF
• Role of the Aryl Hydrocarbon Receptor/ARNT/Cytochrome P450 System in Pulmonary Vascular Diseases.
  Circulation research 2019 Kwapiszewska G, Johansen AKZ, Gomez-Arroyo J, Voelkel NF
• Derivation and validation of a simple inflammation-based risk score system for predicting in-hospital mortality in acute coronary syndrome patients.
  Journal of cardiology 2018 González-Pacheco H, Bojalil R, Amezcua-Guerra LM, Sandoval J, Eid-Lidt G, Arias-Mendoza A, Azar-Manzur F, Álvarez-Sangabriel A, Altamirano-Castillo A, Briseño-Cruz JL, Carrillo-Vega J, Vazquez-Rangel …
• Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets.
  Cancer cell 2017 Best MG, Sol N, In 't Veld SGJG, Vancura A, Muller M, Niemeijer AN, Fejes AV, Tjon Kon Fat LA, Huis In 't Veld AE, Leurs C, Le Large TY, Meijer LL, Kooi IE, Rustenburg F, Schellen P, Verschueren H, …
• p53 Signaling Pathway Polymorphisms Associated With Emphysematous Changes in Patients With COPD.
  Chest 2017 Mizuno S, Ishizaki T, Kadowaki M, Akai M, Shiozaki K, Iguchi M, Oikawa T, Nakagawa K, Osanai K, Toga H, Gomez-Arroyo J, Kraskauskas D, Cool CD, Bogaard HJ, Voelkel NF
• Targeting Neurohormonal Activation in Pulmonary Arterial Hypertension: Putting the Puzzle Together.
  JACC. Basic to translational science 2017 Gomez-Arroyo J, Voelkel NF, Huizar JF, Abbate A
• Pulmonary arterial hypertension and the Enigma code of smouldering inflammation.
  The European respiratory journal 2016 Gomez-Arroyo J, Abbate A, Voelkel NF
• Interventional and surgical therapeutic strategies for pulmonary arterial hypertension: Beyond palliative treatments.
  Journal of cardiology 2015 Sandoval J, Gomez-Arroyo J, Gaspar J, Pulido-Zamudio T
• The need to recognize the pulmonary circulation and the right ventricle as an integrated functional unit: facts and hypotheses (2013 Grover Conference series).
  Pulmonary circulation 2015 Voelkel NF, Bogaard HJ, Gomez-Arroyo J
• The role of vascular endothelial growth factor in pulmonary arterial hypertension. The angiogenesis paradox.
  American journal of respiratory cell and molecular biology 2014 Voelkel NF, Gomez-Arroyo J
• Iloprost reverses established fibrosis in experimental right ventricular failure.
  The European respiratory journal 2014 Gomez-Arroyo J, Sakagami M, Syed AA, Farkas L, Van Tassell B, Kraskauskas D, Mizuno S, Abbate A, Bogaard HJ, Byron PR, Voelkel NF
• Treatment for pulmonary arterial hypertension-associated right ventricular dysfunction.
  Annals of the American Thoracic Society 2014 Gomez-Arroyo J, Sandoval J, Simon MA, Dominguez-Cano E, Voelkel NF, Bogaard HJ
• Histone deacetylase inhibition with trichostatin A does not reverse severe angioproliferative pulmonary hypertension in rats (2013 Grover Conference series).
  Pulmonary circulation 2014 De Raaf MA, Hussaini AA, Gomez-Arroyo J, Kraskaukas D, Farkas D, Happé C, Voelkel NF, Bogaard HJ
• SuHx rat model: partly reversible pulmonary hypertension and progressive intima obstruction.
  The European respiratory journal 2014 de Raaf MA, Schalij I, Gomez-Arroyo J, Rol N, Happé C, de Man FS, Vonk-Noordegraaf A, Westerhof N, Voelkel NF, Bogaard HJ
• Differences in right ventricular remodeling secondary to pressure overload in patients with pulmonary hypertension.
  American journal of respiratory and critical care medicine 2014 Gomez-Arroyo J, Santos-Martinez LE, Aranda A, Pulido T, Beltran M, Muñoz-Castellanos L, Dominguez-Cano E, Sonnino C, Voelkel NF, Sandoval J
• Chronic carvedilol treatment partially reverses the right ventricular failure transcriptional profile in experimental pulmonary hypertension.
  Physiological genomics 2013 Drake JI, Gomez-Arroyo J, Dumur CI, Kraskauskas D, Natarajan R, Bogaard HJ, Fawcett P, Voelkel NF
• Mechanisms of right heart failure-A work in progress and a plea for failure prevention.
  Pulmonary circulation 2013 Voelkel NF, Gomez-Arroyo J, Abbate A, Bogaard HJ
• Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension.
  Circulation. Heart failure 2012 Gomez-Arroyo J, Mizuno S, Szczepanek K, Van Tassell B, Natarajan R, dos Remedios CG, Drake JI, Farkas L, Kraskauskas D, Wijesinghe DS, Chalfant CE, Bigbee J, Abbate A, Lesnefsky EJ, Bogaard HJ, …
• New models of pulmonary hypertension based on VEGF receptor blockade-induced endothelial cell apoptosis.
  Pulmonary circulation 2012 Nicolls MR, Mizuno S, Taraseviciene-Stewart L, Farkas L, Drake JI, Al Husseini A, Gomez-Arroyo JG, Voelkel NF, Bogaard HJ
• Antioxidants for the treatment of patients with severe angioproliferative pulmonary hypertension?
  Antioxidants & redox signaling 2012 Voelkel NF, Bogaard HJ, Al Husseini A, Farkas L, Gomez-Arroyo J, Natarajan R
• MicroRNA-199a-5p is associated with hypoxia-inducible factor-1α expression in lungs from patients with COPD.
  Chest 2012 Mizuno S, Bogaard HJ, Gomez-Arroyo J, Alhussaini A, Kraskauskas D, Cool CD, Voelkel NF
• Severe pulmonary arterial hypertension induced by SU5416 and ovalbumin immunization.
  American journal of respiratory cell and molecular biology 2012 Mizuno S, Farkas L, Al Husseini A, Farkas D, Gomez-Arroyo J, Kraskauskas D, Nicolls MR, Cool CD, Bogaard HJ, Voelkel NF
• Thyroid hormone is highly permissive in angioproliferative pulmonary hypertension in rats.
  The European respiratory journal 2012 Al Husseini A, Bagnato G, Farkas L, Gomez-Arroyo J, Farkas D, Mizuno S, Kraskauskas D, Abbate A, Van Tassel B, Voelkel NF, Bogaard HJ
• Pathobiology of pulmonary arterial hypertension and right ventricular failure.
  The European respiratory journal 2012 Voelkel NF, Gomez-Arroyo J, Abbate A, Bogaard HJ, Nicolls MR
• Severe pulmonary hypertension: The role of metabolic and endocrine disorders.
  Pulmonary circulation 2012 Bogaard HJ, Al Husseini A, Farkas L, Farkas D, Gomez-Arroyo J, Abbate A, Voelkel NF
• A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects.
  American journal of physiology. Lung cellular and molecular physiology 2012 Gomez-Arroyo J, Saleem SJ, Mizuno S, Syed AA, Bogaard HJ, Abbate A, Taraseviciene-Stewart L, Sung Y, Kraskauskas D, Farkas D, Conrad DH, Nicolls MR, Voelkel NF
• Copper deficiency induced emphysema is associated with focal adhesion kinase inactivation.
  PloS one 2012 Mizuno S, Yasuo M, Bogaard HJ, Kraskauskas D, Alhussaini A, Gomez-Arroyo J, Farkas D, Farkas L, Voelkel NF
• Right ventricular systolic dysfunction in patients with reperfused ST-segment elevation acute myocardial infarction.
  International journal of cardiology 2011 Van Tassell BW, Bhardwaj HL, Grizzard JD, Kontos MC, Bogaard H, Gomez-Arroyo J, Toldo S, Mezzaroma E, Voelkel NF, Abbate A
• The monocrotaline model of pulmonary hypertension in perspective.
  American journal of physiology. Lung cellular and molecular physiology 2011 Gomez-Arroyo JG, Farkas L, Alhussaini AA, Farkas D, Kraskauskas D, Voelkel NF, Bogaard HJ
• The harmonics of rodent pulmonary hypertension models.
  International journal of clinical practice. Supplement 2011 Voelkel NF, Gomez-Arroyo J
• COPD/emphysema: The vascular story.
  Pulmonary circulation 2011 Voelkel NF, Gomez-Arroyo J, Mizuno S
• p53 Gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice.
  American journal of physiology. Lung cellular and molecular physiology 2011 Mizuno S, Bogaard HJ, Kraskauskas D, Alhussaini A, Gomez-Arroyo J, Voelkel NF, Ishizaki T