Jonathan Weissman, PhD
Professor
Cellular Molecular Pharmacology
School of Medicine

Websites

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• Profile at weissmanlab.ucsf.edu (weissmanlab.ucsf.edu)

Grants and Projects

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• The Cancer Target Discovery and Development Network at UCSF, NIH, 2017-2022
• Harnessing CRISPR for Targeted and Inducible Epigenomic Reprogramming, NIH, 2013-2018
• Human Gene Knockdowns that May Extend Lifespan, NIH, 2012-2018
• Bay Area Cancer Target Discovery and Development Network, NIH, 2012-2017
• Structural Basis of Protein Homeostasis, NIH, 2012-2016
• Molecular Pathogenesis of Age-Dependent CNS Regeneration, NIH, 1993-2016
• Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
• Mechanism of Chaperone Mediated Protein Folding, NIH, 1997-2002

Publications (343)

Top publication keywords:
Peptide Chain Initiation, TranslationalSaccharomyces cerevisiae ProteinsProtein FoldingRNA, MessengerCRISPR-Cas SystemsEpistasis, GeneticSaccharomyces cerevisiaeSequence Analysis, RNAPrionsClustered Regularly Interspaced Short Palindromic RepeatsRibosomesProtein BiosynthesisSingle-Cell AnalysisFungal ProteinsEndoplasmic Reticulum

• CD47 predominates over CD24 as a macrophage immune checkpoint in cancer.
  bioRxiv : the preprint server for biology 2024 Allen J, Meglan A, Vaccaro K, Velarde J, Chen V, Ribeiro J, Blandin J, Gupta S, Mishra R, Ho R, Love J, Reinhardt F, Bell GW, Chen J, Weinberg R, Yang D, Weissman J, Weiskopf K
• A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function.
  bioRxiv : the preprint server for biology 2024 Saunders RA, Allen WE, Pan X, Sandhu J, Lu J, Lau TK, Smolyar K, Sullivan ZA, Dulac C, Weissman JS, Zhuang X
• FET fusion oncoproteins disrupt physiologic DNA repair networks in cancer.
  bioRxiv : the preprint server for biology 2024 Menon S, Gracilla D, Breese MR, Lin YP, Cruz FD, Feinberg T, de Stanchina E, Galic AF, Allegakoen H, Perati S, Wen N, Heslin A, Horlbeck MA, Weissman J, Sweet-Cordero EA, Bivona TG, Tulpule A
• Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death.
  bioRxiv : the preprint server for biology 2024 Lam B, Kajderowicz KM, Keys HR, Roessler JM, Frenkel EM, Kirkland A, Bisht P, El-Brolosy MA, Jaenisch R, Bell GW, Weissman JS, Griffith EC, Hrvatin S
• Spatiotemporal modeling of molecular holograms.
  Cell 2024 Qiu X, Zhu DY, Lu Y, Yao J, Jing Z, Min KH, Cheng M, Pan H, Zuo L, King S, Fang Q, Zheng H, Wang M, Wang S, Zhang Q, Yu S, Liao S, Liu C, Wu X, Lai Y, Hao S, Zhang Z, Wu L, Zhang Y, Li M, Tu Z, Lin J,…

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• Combinatorial effector targeting (COMET) for transcriptional modulation and locus-specific biochemistry.
  bioRxiv : the preprint server for biology 2024 Wilson CM, Pommier GC, Richman DD, Sambold N, Hussmann JA, Weissman JS, Gilbert LA
• Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis.
  bioRxiv : the preprint server for biology 2024 Jones MG, Sun D, Min KHJ, Colgan WN, Tian L, Weir JA, Chen VZ, Koblan LW, Yost KE, Mathey-Andrews N, Russell AJC, Stickels RR, Balderrama KS, Rideout WM, Chang HY, Jacks T, Chen F, Weissman JS, Yosef …
• High-quality peptide evidence for annotating non-canonical open reading frames as human proteins.
  bioRxiv : the preprint server for biology 2024 Deutsch EW, Kok LW, Mudge JM, Ruiz-Orera J, Fierro-Monti I, Sun Z, Abelin JG, Alba MM, Aspden JL, Bazzini AA, Bruford EA, Brunet MA, Calviello L, Carr SA, Carvunis AR, Chothani S, Clauwaert J, Dean K,…
• Robustness and reliability of single-cell regulatory multi-omics with deep mitochondrial mutation profiling.
  bioRxiv : the preprint server for biology 2024 Weng C, Weissman JS, Sankaran VG
• Transcriptome-wide characterization of genetic perturbations.
  bioRxiv : the preprint server for biology 2024 Nadig A, Replogle JM, Pogson AN, McCarroll SA, Weissman JS, Robinson EB, O'Connor LJ
• Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor.
  Science (New York, N.Y.) 2024 Neumann EN, Bertozzi TM, Wu E, Serack F, Harvey JW, Brauer PP, Pirtle CP, Coffey A, Howard M, Kamath N, Lenz K, Guzman K, Raymond MH, Khalil AS, Deverman BE, Minikel EV, Vallabh SM, Weissman JS
• Author Correction: CRISPR technologies for genome, epigenome and transcriptome editing.
  Nature reviews. Molecular cell biology 2024 Villiger L, Joung J, Koblan L, Weissman J, Abudayyeh OO, Gootenberg JS
• Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress.
  Developmental cell 2024 Do BT, Hsu PP, Vermeulen SY, Wang Z, Hirz T, Abbott KL, Aziz N, Replogle JM, Bjelosevic S, Paolino J, Nelson SA, Block S, Darnell AM, Ferreira R, Zhang H, Milosevic J, Schmidt DR, Chidley C, Harris IS…
• CRISPRi screens identify the lncRNA, LOUP, as a multifunctional locus regulating macrophage differentiation and inflammatory signaling.
  Proceedings of the National Academy of Sciences of the United States of America 2024 Halasz H, Malekos E, Covarrubias S, Yitiz S, Montano C, Sudek L, Katzman S, Liu SJ, Horlbeck MA, Namvar L, Weissman JS, Carpenter S
• Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding.
  Nature neuroscience 2024 Hacisuleyman E, Hale CR, Noble N, Luo JD, Fak JJ, Saito M, Chen J, Weissman JS, Darnell RB
• Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.
  Molecular cell 2024 Muthukumar G, Stevens TA, Inglis AJ, Esantsi TK, Saunders RA, Schulte F, Voorhees RM, Guna A, Weissman JS
• CRISPR technologies for genome, epigenome and transcriptome editing.
  Nature reviews. Molecular cell biology 2024 Villiger L, Joung J, Koblan L, Weissman J, Abudayyeh OO, Gootenberg JS
• Deciphering cell states and genealogies of human haematopoiesis.
  Nature 2024 Weng C, Yu F, Yang D, Poeschla M, Liggett LA, Jones MG, Qiu X, Wahlster L, Caulier A, Hussmann JA, Schnell A, Yost KE, Koblan LW, Martin-Rufino JD, Min J, Hammond A, Ssozi D, Bueno R, Mallidi H, Kreso…
• Author Correction: Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning.
  Nature biotechnology 2023 Koblan LW, Arbab M, Shen MW, Hussmann JA, Anzalone AV, Doman JL, Newby GA, Yang D, Mok B, Replogle JM, Xu A, Sisley TA, Weissman JS, Adamson B, Liu DR
• A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens.
  BMC genomics 2023 Guna A, Page KR, Replogle JM, Esantsi TK, Wang ML, Weissman JS, Voorhees RM
• Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq.
  Nature communications 2023 Sunshine S, Puschnik AS, Replogle JM, Laurie MT, Liu J, Zha BS, Nuñez JK, Byrum JR, McMorrow AH, Frieman MB, Winkler J, Qiu X, Rosenberg OS, Leonetti MD, Ye CJ, Weissman JS, DeRisi JL, Hein MY
• Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.
  bioRxiv : the preprint server for biology 2023 Muthukumar G, Stevens TA, Inglis AJ, Esantsi TK, Saunders RA, Schulte F, Voorhees RM, Guna A, Weissman JS
• A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens.
  bioRxiv : the preprint server for biology 2023 Guna A, Page KR, Replogle JM, Esantsi TK, Wang ML, Weissman JS, Voorhees RM
• Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity.
  Nucleic acids research 2023 She R, Luo J, Weissman JS
• Comparative landscape of genetic dependencies in human and chimpanzee stem cells.
  Cell 2023 She R, Fair T, Schaefer NK, Saunders RA, Pavlovic BJ, Weissman JS, Pollen AA
• FET fusion oncoproteins disrupt physiologic DNA repair networks and induce ATR synthetic lethality in cancer.
  Research square 2023 Menon S, Breese MR, Lin YP, Allegakoen H, Perati S, Heslin A, Horlbeck MA, Weissman J, Sweet-Cordero EA, Bivona TG, Tulpule A
• Coupled protein quality control during nonsense-mediated mRNA decay.
  Journal of cell science 2023 Inglis AJ, Guna A, Gálvez-Merchán Á, Pal A, Esantsi TK, Keys HR, Frenkel EM, Oania R, Weissman JS, Voorhees RM
• Comparative landscape of genetic dependencies in human and chimpanzee stem cells.
  bioRxiv : the preprint server for biology 2023 She R, Fair T, Schaefer NK, Saunders RA, Pavlovic BJ, Weissman JS, Pollen AA
• Microfluidics-free single-cell genomics with templated emulsification.
  Nature biotechnology 2023 Clark IC, Fontanez KM, Meltzer RH, Xue Y, Hayford C, May-Zhang A, D'Amato C, Osman A, Zhang JQ, Hettige P, Ishibashi JSA, Delley CL, Weisgerber DW, Replogle JM, Jost M, Phong KT, Kennedy VE, Peretz …
• Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors.
  eLife 2022 Replogle JM, Bonnar JL, Pogson AN, Liem CR, Maier NK, Ding Y, Russell BJ, Wang X, Leng K, Guna A, Norman TM, Pak RA, Ramos DM, Ward ME, Gilbert LA, Kampmann M, Weissman JS, Jost M
• GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion-positive rhabdomyosarcoma.
  JCI insight 2022 Morales J, Allegakoen DV, Garcia JA, Kwong K, Sahu PK, Fajardo DA, Pan Y, Horlbeck MA, Weissman JS, Gustafson WC, Bivona TG, Sabnis AJ
• MTCH2 is a mitochondrial outer membrane protein insertase.
  Science (New York, N.Y.) 2022 Guna A, Stevens TA, Inglis AJ, Replogle JM, Esantsi TK, Muthukumar G, Shaffer KCL, Wang ML, Pogson AN, Jones JJ, Lomenick B, Chou TF, Weissman JS, Voorhees RM
• Cellular barcoding to decipher clonal dynamics in disease.
  Science (New York, N.Y.) 2022 Sankaran VG, Weissman JS, Zon LI
• Dual genome-wide coding and lncRNA screens in neural induction of induced pluripotent stem cells.
  Cell genomics 2022 Wu D, Poddar A, Ninou E, Hwang E, Cole MA, Liu SJ, Horlbeck MA, Chen J, Replogle JM, Carosso GA, Eng NWL, Chang J, Shen Y, Weissman JS, Lim DA
• Adaptive exchange sustains cullin-RING ubiquitin ligase networks and proper licensing of DNA replication.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Zhang Y, Jost M, Pak RA, Lu D, Li J, Lomenick B, Garbis SD, Li CM, Weissman JS, Lipford JR, Deshaies RJ
• Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice.
  Nature biotechnology 2022 Tolani B, Celli A, Yao Y, Tan YZ, Fetter R, Liem CR, de Smith AJ, Vasanthakumar T, Bisignano P, Cotton AD, Seiple IB, Rubinstein JL, Jost M, Weissman JS
• A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities.
  Cell chemical biology 2022 Shao H, Taguwa S, Gilbert L, Shkedi A, Sannino S, Guerriero CJ, Gale-Day ZJ, Young ZT, Brodsky JL, Weissman J, Gestwicki JE, Frydman J
• Standardized annotation of translated open reading frames.
  Nature biotechnology 2022 Mudge JM, Ruiz-Orera J, Prensner JR, Brunet MA, Calvet F, Jungreis I, Gonzalez JM, Magrane M, Martinez TF, Schulz JF, Yang YT, Albà MM, Aspden JL, Baranov PV, Bazzini AA, Bruford E, Martin MJ, …
• Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq.
  Cell 2022 Replogle JM, Saunders RA, Pogson AN, Hussmann JA, Lenail A, Guna A, Mascibroda L, Wagner EJ, Adelman K, Lithwick-Yanai G, Iremadze N, Oberstrass F, Lipson D, Bonnar JL, Jost M, Norman TM, Weissman JS
• Variant to function mapping at single-cell resolution through network propagation.
  Nature biotechnology 2022 Yu F, Cato LD, Weng C, Liggett LA, Jeon S, Xu K, Chiang CWK, Wiemels JL, Weissman JS, de Smith AJ, Sankaran VG
• Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution.
  Cell 2022 Yang D, Jones MG, Naranjo S, Rideout WM, Min KHJ, Ho R, Wu W, Replogle JM, Page JL, Quinn JJ, Horns F, Qiu X, Chen MZ, Freed-Pastor WA, McGinnis CS, Patterson DM, Gartner ZJ, Chow ED, Bivona TG, Chan …
• OpenCell: Endogenous tagging for the cartography of human cellular organization.
  Science (New York, N.Y.) 2022 Cho NH, Cheveralls KC, Brunner AD, Kim K, Michaelis AC, Raghavan P, Kobayashi H, Savy L, Li JY, Canaj H, Kim JYS, Stewart EM, Gnann C, McCarthy F, Cabrera JP, Brunetti RM, Chhun BB, Dingle G, Hein MY,…
• High-content CRISPR screening.
  Nature reviews. Methods primers 2022 Bock C, Datlinger P, Chardon F, Coelho MA, Dong MB, Lawson KA, Lu T, Maroc L, Norman TM, Song B, Stanley G, Chen S, Garnett M, Li W, Moffat J, Qi LS, Shapiro RS, Shendure J, Weissman JS, Zhuang X
• Mapping transcriptomic vector fields of single cells.
  Cell 2022 Qiu X, Zhang Y, Martin-Rufino JD, Weng C, Hosseinzadeh S, Yang D, Pogson AN, Hein MY, Hoi Joseph Min K, Wang L, Grody EI, Shurtleff MJ, Yuan R, Xu S, Ma Y, Replogle JM, Lander ES, Darmanis S, Bahar I,…
• Variant to function mapping at single-cell resolution through network propagation.
  bioRxiv : the preprint server for biology 2022 Yu F, Cato LD, Weng C, Liggett LA, Jeon S, Xu K, Chiang CWK, Wiemels JL, Weissman JS, de Smith AJ, Sankaran VG
• BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.
  Nature cell biology 2022 Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Kain AM, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nuñez JK, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman…
• Peroxisome function relies on organelle-associated mRNA translation.
  Science advances 2022 Dahan N, Bykov YS, Boydston EA, Fadel A, Gazi Z, Hochberg-Laufer H, Martenson J, Denic V, Shav-Tal Y, Weissman JS, Aviram N, Zalckvar E, Schuldiner M
• The dark proteome: translation from noncanonical open reading frames.
  Trends in cell biology 2021 Wright BW, Yi Z, Weissman JS, Chen J
• Functional single-cell genomics of human cytomegalovirus infection.
  Nature biotechnology 2021 Hein MY, Weissman JS
• Mapping the genetic landscape of DNA double-strand break repair.
  Cell 2021 Hussmann JA, Ling J, Ravisankar P, Yan J, Cirincione A, Xu A, Simpson D, Yang D, Bothmer A, Cotta-Ramusino C, Weissman JS, Adamson B
• Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.
  Cell 2021 Chen PJ, Hussmann JA, Yan J, Knipping F, Ravisankar P, Chen PF, Chen C, Nelson JW, Newby GA, Sahin M, Osborn MJ, Weissman JS, Adamson B, Liu DR
• BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.
  bioRxiv : the preprint server for biology 2021 Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Mac Kain A, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nunez J, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, …
• Structured elements drive extensive circular RNA translation.
  Molecular cell 2021 Chen CK, Cheng R, Demeter J, Chen J, Weingarten-Gabbay S, Jiang L, Snyder MP, Weissman JS, Segal E, Jackson PK, Chang HY
• An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens.
  eLife 2021 Coukos R, Yao D, Sanchez MI, Strand ET, Olive ME, Udeshi ND, Weissman JS, Carr SA, Bassik MC, Ting AY
• Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning.
  Nature biotechnology 2021 Koblan LW, Arbab M, Shen MW, Hussmann JA, Anzalone AV, Doman JL, Newby GA, Yang D, Mok B, Replogle JM, Xu A, Sisley TA, Weissman JS, Adamson B, Liu DR
• Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.
  eLife 2021 Le Vasseur M, Friedman J, Jost M, Xu J, Yamada J, Kampmann M, Horlbeck MA, Salemi MR, Phinney BS, Weissman JS, Nunnari J
• CRISPR-based functional genomics in human dendritic cells.
  eLife 2021 Jost M, Jacobson AN, Hussmann JA, Cirolia G, Fischbach MA, Weissman JS
• Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing.
  Cell 2021 Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, Pogson AN, Kim JYS, Chung A, Leonetti MD, Chang HY, Kampmann M, Bernstein BE, Hovestadt V, …
• Regulation of translation by methylation multiplicity of 18S rRNA.
  Cell reports 2021 Liu K, Santos DA, Hussmann JA, Wang Y, Sutter BM, Weissman JS, Tu BP
• Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.
  Cell 2021 Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA
• High-content imaging-based pooled CRISPR screens in mammalian cells.
  The Journal of cell biology 2021 Yan X, Stuurman N, Ribeiro SA, Tanenbaum ME, Horlbeck MA, Liem CR, Jost M, Weissman JS, Vale RD
• Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts.
  Science (New York, N.Y.) 2021 Quinn JJ, Jones MG, Okimoto RA, Nanjo S, Chan MM, Yosef N, Bivona TG, Weissman JS
• A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation.
  Cancer discovery 2021 Lo YH, Kolahi KS, Du Y, Chang CY, Krokhotin A, Nair A, Sobba WD, Karlsson K, Jones SJ, Longacre TA, Mah AT, Tercan B, Sockell A, Xu H, Seoane JA, Chen J, Shmulevich I, Weissman JS, Curtis C, Califano …
• Genome-Scale Perturbation of Long Noncoding RNA Expression Using CRISPR Interference.
  Methods in molecular biology (Clifton, N.J.) 2021 Liu SJ, Horlbeck MA, Weissman JS, Lim DA
• Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients.
  eLife 2020 Miller-Vedam LE, Bräuning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS
• Mismatch-CRISPRi Reveals the Co-varying Expression-Fitness Relationships of Essential Genes in Escherichia coli and Bacillus subtilis.
  Cell systems 2020 Hawkins JS, Silvis MR, Koo BM, Peters JM, Osadnik H, Jost M, Hearne CC, Weissman JS, Todor H, Gross CA
• Conserved Functions of Ether Lipids and Sphingolipids in the Early Secretory Pathway.
  Current biology : CB 2020 Jiménez-Rojo N, Leonetti MD, Zoni V, Colom A, Feng S, Iyengar NR, Matile S, Roux A, Vanni S, Weissman JS, Riezman H
• Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing.
  Cell 2020 Maynard A, McCoach CE, Rotow JK, Harris L, Haderk F, Kerr DL, Yu EA, Schenk EL, Tan W, Zee A, Tan M, Gui P, Lea T, Wu W, Urisman A, Jones K, Sit R, Kolli PK, Seeley E, Gesthalter Y, Le DD, Yamauchi KA…
• Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span.
  Science advances 2020 Zou K, Rouskin S, Dervishi K, McCormick MA, Sasikumar A, Deng C, Chen Z, Kaeberlein M, Brem RB, Polymenis M, Kennedy BK, Weissman JS, Zheng J, Ouyang Q, Li H
• GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.
  Molecular cell 2020 Hickey KL, Dickson K, Cogan JZ, Replogle JM, Schoof M, D'Orazio KN, Sinha NK, Hussmann JA, Jost M, Frost A, Green R, Weissman JS, Kostova KK
• Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent.
  Molecular cell 2020 Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS
• Polysomes Bypass a 50-Nucleotide Coding Gap Less Efficiently Than Monosomes Due to Attenuation of a 5' mRNA Stem-Loop and Enhanced Drop-off.
  Journal of molecular biology 2020 O'Loughlin S, Capece MC, Klimova M, Wills NM, Coakley A, Samatova E, O'Connor PBF, Loughran G, Weissman JS, Baranov PV, Rodnina MV, Puglisi JD, Atkins JF
• Inference of single-cell phylogenies from lineage tracing data using Cassiopeia.
  Genome biology 2020 Jones MG, Khodaverdian A, Quinn JJ, Chan MM, Hussmann JA, Wang R, Xu C, Weissman JS, Yosef N
• CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma.
  Genome biology 2020 Liu SJ, Malatesta M, Lien BV, Saha P, Thombare SS, Hong SJ, Pedraza L, Koontz M, Seo K, Horlbeck MA, He D, Birk HS, Jain M, Olsen HE, Akeson M, Weissman JS, Monje M, Gupta N, Raleigh DR, Ullian EM, …
• Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing.
  Nature biotechnology 2020 Replogle JM, Norman TM, Xu A, Hussmann JA, Chen J, Cogan JZ, Meer EJ, Terry JM, Riordan DP, Srinivas N, Fiddes IT, Arthur JG, Alvarado LJ, Pfeiffer KA, Mikkelsen TS, Weissman JS, Adamson B
• Pervasive functional translation of noncanonical human open reading frames.
  Science (New York, N.Y.) 2020 Chen J, Brunner AD, Cogan JZ, Nuñez JK, Fields AP, Adamson B, Itzhak DN, Li JY, Mann M, Leonetti MD, Weissman JS
• Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes.
  Nature biotechnology 2020 Horlbeck MA, Liu SJ, Chang HY, Lim DA, Weissman JS
• Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs.
  Nature biotechnology 2020 Jost M, Santos DA, Saunders RA, Horlbeck MA, Hawkins JS, Scaria SM, Norman TM, Hussmann JA, Liem CR, Gross CA, Weissman JS
• The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration.
  Genes & development 2020 Vargas EJM, Matamoros AJ, Qiu J, Jan CH, Wang Q, Gorczyca D, Han TW, Weissman JS, Jan YN, Banerjee S, Song Y
• Variation in expenditure for common, high cost surgical procedures in a working age population: implications for reimbursement reform.
  BMC health services research 2019 Wynn-Jones W, Koehlmoos TP, Tompkins C, Navathe A, Lipsitz S, Kwon NK, Learn PA, Madsen C, Schoenfeld A, Weissman JS
• The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins.
  eLife 2019 Ngo AM, Shurtleff MJ, Popova KD, Kulsuptrakul J, Weissman JS, Puschnik AS
• New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells.
  The Journal of cell biology 2019 Bassaganyas L, Popa SJ, Horlbeck M, Puri C, Stewart SE, Campelo F, Ashok A, Butnaru CM, Brouwers N, Heydari K, Ripoche J, Weissman J, Rubinsztein DC, Schekman R, Malhotra V, Moreau K, Villeneuve J
• Exploring genetic interaction manifolds constructed from rich single-cell phenotypes.
  Science (New York, N.Y.) 2019 Norman TM, Horlbeck MA, Replogle JM, Ge AY, Xu A, Jost M, Gilbert LA, Weissman JS
• MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices.
  Nature methods 2019 McGinnis CS, Patterson DM, Winkler J, Conrad DN, Hein MY, Srivastava V, Hu JL, Murrow LM, Weissman JS, Werb Z, Chow ED, Gartner ZJ
• Cycloheximide can distort measurements of mRNA levels and translation efficiency.
  Nucleic acids research 2019 Santos DA, Shi L, Tu BP, Weissman JS
• Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether.
  eLife 2019 Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P
• Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Igbaria A, Merksamer PI, Trusina A, Tilahun F, Johnson JR, Brandman O, Krogan NJ, Weissman JS, Papa FR
• Molecular recording of mammalian embryogenesis.
  Nature 2019 Chan MM, Smith ZD, Grosswendt S, Kretzmer H, Norman TM, Adamson B, Jost M, Quinn JJ, Yang D, Jones MG, Khodaverdian A, Yosef N, Meissner A, Weissman JS
• Ribosome Profiling: Global Views of Translation.
  Cold Spring Harbor perspectives in biology 2019 Ingolia NT, Hussmann JA, Weissman JS
• Cellular response to small molecules that selectively stall protein synthesis by the ribosome.
  PLoS genetics 2019 Liaud N, Horlbeck MA, Gilbert LA, Gjoni K, Weissman JS, Cate JHD
• Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids.
  Molecular cell 2019 Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD, Paulo JA, Harper JW, Weissman JS, Walther TC, Farese RV
• Mapping the Genetic Landscape of Human Cells.
  Cell 2018 Horlbeck MA, Xu A, Wang M, Bennett NK, Park CY, Bogdanoff D, Adamson B, Chow ED, Kampmann M, Peterson TR, Nakamura K, Fischbach MA, Weissman JS, Gilbert LA
• Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70).
  Journal of medicinal chemistry 2018 Shao H, Li X, Moses MA, Gilbert LA, Kalyanaraman C, Young ZT, Chernova M, Journey SN, Weissman JS, Hann B, Jacobson MP, Neckers L, Gestwicki JE
• Reprogramming human T cell function and specificity with non-viral genome targeting.
  Nature 2018 Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta…
• Engineering ER-stress dependent non-conventional mRNA splicing.
  eLife 2018 Li W, Okreglak V, Peschek J, Kimmig P, Zubradt M, Weissman JS, Walter P
• The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs.
  Nature 2018 Guenther UP, Weinberg DE, Zubradt MM, Tedeschi FA, Stawicki BN, Zagore LL, Brar GA, Licatalosi DD, Bartel DP, Weissman JS, Jankowsky E
• The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins.
  eLife 2018 Shurtleff MJ, Itzhak DN, Hussmann JA, Schirle Oakdale NT, Costa EA, Jonikas M, Weibezahn J, Popova KD, Jan CH, Sinitcyn P, Vembar SS, Hernandez H, Cox J, Burlingame AL, Brodsky JL, Frost A, Borner GH,…
• Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform.
  Hepatology (Baltimore, Md.) 2018 Wangensteen KJ, Wang YJ, Dou Z, Wang AW, Mosleh-Shirazi E, Horlbeck MA, Gilbert LA, Weissman JS, Berger SL, Kaestner KH
• Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates.
  eLife 2018 Yu Z, Surface LE, Park CY, Horlbeck MA, Wyant GA, Abu-Remaileh M, Peterson TR, Sabatini DM, Weissman JS, O'Shea EK
• Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element.
  Cell 2018 Cho SW, Xu J, Sun R, Mumbach MR, Carter AC, Chen YG, Yost KE, Kim J, He J, Nevins SA, Chin SF, Caldas C, Liu SJ, Horlbeck MA, Lim DA, Weissman JS, Curtis C, Chang HY
• A Stress Response that Monitors and Regulates mRNA Structure Is Central to Cold Shock Adaptation.
  Molecular cell 2018 Zhang Y, Burkhardt DH, Rouskin S, Li GW, Weissman JS, Gross CA
• CRISPR Approaches to Small Molecule Target Identification.
  ACS chemical biology 2018 Jost M, Weissman JS
• Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins.
  eLife 2018 Martinko AJ, Truillet C, Julien O, Diaz JE, Horlbeck MA, Whiteley G, Blonder J, Weissman JS, Bandyopadhyay S, Evans MJ, Wells JA
• Defining the physiological role of SRP in protein-targeting efficiency and specificity.
  Science (New York, N.Y.) 2018 Costa EA, Subramanian K, Nunnari J, Weissman JS
• Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER.
  Developmental cell 2017 Friedman JR, Kannan M, Toulmay A, Jan CH, Weissman JS, Prinz WA, Nunnari J
• The Human Cell Atlas.
  eLife 2017 Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, Enard W, Farmer A, Fugger L, …
• Inducible and multiplex gene regulation using CRISPR-Cpf1-based transcription factors.
  Nature methods 2017 Tak YE, Kleinstiver BP, Nuñez JK, Hsu JY, Horng JE, Gong J, Weissman JS, Joung JK
• Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent.
  Molecular cell 2017 Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS
• CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides.
  Science (New York, N.Y.) 2017 Kostova KK, Hickey KL, Osuna BA, Hussmann JA, Frost A, Weinberg DE, Weissman JS
• Minimally invasive surgery and its impact on 30-day postoperative complications, unplanned readmissions and mortality.
  The British journal of surgery 2017 Sood A, Meyer CP, Abdollah F, Sammon JD, Sun M, Lipsitz SR, Hollis M, Weissman JS, Menon M, Trinh QD
• Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia.
  Blood 2017 Kruth KA, Fang M, Shelton DN, Abu-Halawa O, Mahling R, Yang H, Weissman JS, Loh ML, Müschen M, Tasian SK, Bassik MC, Kampmann M, Pufall MA
• Operon mRNAs are organized into ORF-centric structures that predict translation efficiency.
  eLife 2017 Burkhardt DH, Rouskin S, Zhang Y, Li GW, Weissman JS, Gross CA
• Translation from unconventional 5' start sites drives tumour initiation.
  Nature 2017 Sendoel A, Dunn JG, Rodriguez EH, Naik S, Gomez NC, Hurwitz B, Levorse J, Dill BD, Schramek D, Molina H, Weissman JS, Fuchs E
• A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response.
  Cell 2016 Adamson B, Norman TM, Jost M, Cho MY, Nuñez JK, Chen Y, Villalta JE, Gilbert LA, Horlbeck MA, Hein MY, Pak RA, Gray AN, Gross CA, Dixit A, Parnas O, Regev A, Weissman JS
• CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells.
  Science (New York, N.Y.) 2016 Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman JS, Lim DA
• Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens.
  Cell 2016 Dixit A, Parnas O, Li B, Chen J, Fulco CP, Jerby-Arnon L, Marjanovic ND, Dionne D, Burks T, Raychowdhury R, Adamson B, Norman TM, Lander ES, Weissman JS, Friedman N, Regev A
• The mTOR Complex Controls HIV Latency.
  Cell host & microbe 2016 Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman …
• The SND proteins constitute an alternative targeting route to the endoplasmic reticulum.
  Nature 2016 Aviram N, Ast T, Costa EA, Arakel EC, Chuartzman SG, Jan CH, Haßdenteufel S, Dudek J, Jung M, Schorr S, Zimmermann R, Schwappach B, Weissman JS, Schuldiner M
• Plastid: nucleotide-resolution analysis of next-generation sequencing and genomics data.
  BMC genomics 2016 Dunn JG, Weissman JS
• Model-guided optogenetic study of PKA signaling in budding yeast.
  Molecular biology of the cell 2016 Stewart-Ornstein J, Chen S, Bhatnagar R, Weissman JS, El-Samad H
• DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo.
  Nature methods 2016 Zubradt M, Gupta P, Persad S, Lambowitz AM, Weissman JS, Rouskin S
• Dynamic translation regulation in Caulobacter cell cycle control.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Schrader JM, Li GW, Childers WS, Perez AM, Weissman JS, Shapiro L, McAdams HH
• Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.
  eLife 2016 Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman JS
• Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG
• Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity.
  Nature communications 2016 Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA
• Htm1p-Pdi1p is a folding-sensitive mannosidase that marks N-glycoproteins for ER-associated protein degradation.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Liu YC, Fujimori DG, Weissman JS
• Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Braun CJ, Bruno PM, Horlbeck MA, Gilbert LA, Weissman JS, Hemann MT
• A scalable strategy for high-throughput GFP tagging of endogenous human proteins.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Leonetti MD, Sekine S, Kamiyama D, Weissman JS, Huang B
• A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria.
  Cell 2016 Peters JM, Colavin A, Shi H, Czarny TL, Larson MH, Wong S, Hawkins JS, Lu CHS, Koo BM, Marta E, Shiver AL, Whitehead EH, Weissman JS, Brown ED, Qi LS, Huang KC, Gross CA
• Single-cell analysis of long non-coding RNAs in the developing human neocortex.
  Genome biology 2016 Liu SJ, Nowakowski TJ, Pollen AA, Lui JH, Horlbeck MA, Attenello FJ, He D, Weissman JS, Kriegstein AR, Diaz AA, Lim DA
• Versatile protein tagging in cells with split fluorescent protein.
  Nature communications 2016 Kamiyama D, Sekine S, Barsi-Rhyne B, Hu J, Chen B, Gilbert LA, Ishikawa H, Leonetti MD, Marshall WF, Weissman JS, Huang B
• Nucleosomes impede Cas9 access to DNA in vivo and in vitro.
  eLife 2016 Horlbeck MA, Witkowsky LB, Guglielmi B, Replogle JM, Gilbert LA, Villalta JE, Torigoe SE, Tjian R, Weissman JS
• CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs.
  Cell stem cell 2016 Mandegar MA, Huebsch N, Frolov EB, Shin E, Truong A, Olvera MP, Chan AH, Miyaoka Y, Holmes K, Spencer CI, Judge LM, Gordon DE, Eskildsen TV, Villalta JE, Horlbeck MA, Gilbert LA, Krogan NJ, Sheikh SP,…
• A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation.
  Molecular cell 2015 Fields AP, Rodriguez EH, Jovanovic M, Stern-Ginossar N, Haas BJ, Mertins P, Raychowdhury R, Hacohen N, Carr SA, Ingolia NT, Regev A, Weissman JS
• [KIL-d] Protein Element Confers Antiviral Activity via Catastrophic Viral Mutagenesis.
  Molecular cell 2015 Suzuki G, Weissman JS, Tanaka M
• Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis.
  Cancer cell 2015 Anderson DJ, Le Moigne R, Djakovic S, Kumar B, Rice J, Wong S, Wang J, Yao B, Valle E, Kiss von Soly S, Madriaga A, Soriano F, Menon MK, Wu ZY, Kampmann M, Chen Y, Weissman JS, Aftab BT, Yakes FM, …
• Ribosome profiling reveals the what, when, where and how of protein synthesis.
  Nature reviews. Molecular cell biology 2015 Brar GA, Weissman JS
• Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits.
  eLife 2015 Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M
• Regulation of mRNA translation during mitosis.
  eLife 2015 Tanenbaum ME, Stern-Ginossar N, Weissman JS, Vale RD
• Next-generation libraries for robust RNA interference-based genome-wide screens.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Kampmann M, Horlbeck MA, Chen Y, Tsai JC, Bassik MC, Gilbert LA, Villalta JE, Kwon SC, Chang H, Kim VN, Weissman JS
• LOCAL TRANSLATION. Response to Comment on "Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling".
  Science (New York, N.Y.) 2015 Jan CH, Williams CC, Weissman JS
• Oncogenic activation of the PI3-kinase p110β isoform via the tumor-derived PIK3Cβ(D1067V) kinase domain mutation.
  Oncogene 2015 Pazarentzos E, Giannikopoulos P, Hrustanovic G, St John J, Olivas VR, Gubens MA, Balassanian R, Weissman J, Polkinghorn W, Bivona TG
• Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.
  eLife 2015 Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P
• Corrigendum: functional genomics platform for pooled screening and generation of mammalian genetic interaction maps.
  Nature protocols 2015 Kampmann M, Bassik MC, Weissman JS
• Biotechnology. A prudent path forward for genomic engineering and germline gene modification.
  Science (New York, N.Y.) 2015 Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR
• Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens.
  Science (New York, N.Y.) 2015 Jovanovic M, Rooney MS, Mertins P, Przybylski D, Chevrier N, Satija R, Rodriguez EH, Fields AP, Schwartz S, Raychowdhury R, Mumbach MR, Eisenhaure T, Rabani M, Gennert D, Lu D, Delorey T, Weissman JS,…
• Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer.
  Molecular cancer therapeutics 2015 Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE
• Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains.
  Science (New York, N.Y.) 2015 Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost A
• Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation.
  Molecular systems biology 2014 Pop C, Rouskin S, Ingolia NT, Han L, Phizicky EM, Weissman JS, Koller D
• Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds.
  Cell 2014 Zalatan JG, Lee ME, Almeida R, Gilbert LA, Whitehead EH, La Russa M, Tsai JC, Weissman JS, Dueber JE, Qi LS, Lim WA
• Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling.
  Science (New York, N.Y.) 2014 Williams CC, Jan CH, Weissman JS
• Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling.
  Science (New York, N.Y.) 2014 Jan CH, Williams CC, Weissman JS
• The general mode of translation inhibition by macrolide antibiotics.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Kannan K, Kanabar P, Schryer D, Florin T, Oh E, Bahroos N, Tenson T, Weissman JS, Mankin AS
• Genetic influences on translation in yeast.
  PLoS genetics 2014 Albert FW, Muzzey D, Weissman JS, Kruglyak L
• A protein-tagging system for signal amplification in gene expression and fluorescence imaging.
  Cell 2014 Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS, Vale RD
• Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.
  Cell 2014 Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS
• Unraveling the mechanism of cell death induced by chemical fibrils.
  Nature chemical biology 2014 Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA
• Ribosome profiling reveals pervasive translation outside of annotated protein-coding genes.
  Cell reports 2014 Ingolia NT, Brar GA, Stern-Ginossar N, Harris MS, Talhouarne GJ, Jackson SE, Wills MR, Weissman JS
• Misfolded proteins induce aggregation of the lectin Yos9.
  The Journal of biological chemistry 2014 Smith MH, Rodriguez EH, Weissman JS
• The coding and noncoding architecture of the Caulobacter crescentus genome.
  PLoS genetics 2014 Schrader JM, Zhou B, Li GW, Lasker K, Childers WS, Williams B, Long T, Crosson S, McAdams HH, Weissman JS, Shapiro L
• Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps.
  Nature protocols 2014 Kampmann M, Bassik MC, Weissman JS
• A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation.
  Nature communications 2014 van de Weijer ML, Bassik MC, Luteijn RD, Voorburg CM, Lohuis MA, Kremmer E, Hoeben RC, LeProust EM, Chen S, Hoelen H, Ressing ME, Patena W, Weissman JS, McManus MT, Wiertz EJ, Lebbink RJ
• A pause sequence enriched at translation start sites drives transcription dynamics in vivo.
  Science (New York, N.Y.) 2014 Larson MH, Mooney RA, Peters JM, Windgassen T, Nayak D, Gross CA, Block SM, Greenleaf WJ, Landick R, Weissman JS
• Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources.
  Cell 2014 Li GW, Burkhardt D, Gross C, Weissman JS
• Extensive and coordinated control of allele-specific expression by both transcription and translation in Candida albicans.
  Genome research 2014 Muzzey D, Sherlock G, Weissman JS
• Uniform nomenclature for the mitochondrial contact site and cristae organizing system.
  The Journal of cell biology 2014 Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert …
• Differential scales of protein quality control.
  Cell 2014 Wolff S, Weissman JS, Dillin A
• KSHV 2.0: a comprehensive annotation of the Kaposi's sarcoma-associated herpesvirus genome using next-generation sequencing reveals novel genomic and functional features.
  PLoS pathogens 2014 Arias C, Weisburd B, Stern-Ginossar N, Mercier A, Madrid AS, Bellare P, Holdorf M, Weissman JS, Ganem D
• Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system.
  Cell 2013 Chen B, Gilbert LA, Cimini BA, Schnitzbauer J, Zhang W, Li GW, Park J, Blackburn EH, Weissman JS, Qi LS, Huang B
• Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo.
  Nature 2013 Rouskin S, Zubradt M, Washietl S, Kellis M, Weissman JS
• Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster.
  eLife 2013 Dunn JG, Foo CK, Belletier NG, Gavis ER, Weissman JS
• Msn2 coordinates a stoichiometric gene expression program.
  Current biology : CB 2013 Stewart-Ornstein J, Nelson C, DeRisi J, Weissman JS, El-Samad H
• Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens.
  Chemistry & biology 2013 Matheny CJ, Wei MC, Bassik MC, Donnelly AJ, Kampmann M, Iwasaki M, Piloto O, Solow-Cordero DE, Bouley DM, Rau R, Brown P, McManus MT, Weissman JS, Cleary ML
• Global cellular response to chemotherapy-induced apoptosis.
  eLife 2013 Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA
• CRISPR interference (CRISPRi) for sequence-specific control of gene expression.
  Nature protocols 2013 Larson MH, Gilbert LA, Wang X, Lim WA, Weissman JS, Qi LS
• Selective ribosome profiling as a tool for studying the interaction of chaperones and targeting factors with nascent polypeptide chains and ribosomes.
  Nature protocols 2013 Becker AH, Oh E, Weissman JS, Kramer G, Bukau B
• A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern.
  Genes & development 2013 Berchowitz LE, Gajadhar AS, van Werven FJ, De Rosa AA, Samoylova ML, Brar GA, Xu Y, Xiao C, Futcher B, Weissman JS, White FM, Amon A
• CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes.
  Cell 2013 Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS
• Genome-wide annotation and quantitation of translation by ribosome profiling.
  Current protocols in molecular biology 2013 Ingolia NT, Brar GA, Rouskin S, McGeachy AM, Weissman JS
• Ribosome profiling provides evidence that large noncoding RNAs do not encode proteins.
  Cell 2013 Guttman M, Russell P, Ingolia NT, Weissman JS, Lander ES
• Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Kampmann M, Bassik MC, Weissman JS
• rRNA:mRNA pairing alters the length and the symmetry of mRNA-protected fragments in ribosome profiling experiments.
  Bioinformatics (Oxford, England) 2013 O'Connor PB, Li GW, Weissman JS, Atkins JF, Baranov PV
• Aneuploid yeast strains exhibit defects in cell growth and passage through START.
  Molecular biology of the cell 2013 Thorburn RR, Gonzalez C, Brar GA, Christen S, Carlile TM, Ingolia NT, Sauer U, Weissman JS, Amon A
• The contribution of systematic approaches to characterizing the proteins and functions of the endoplasmic reticulum.
  Cold Spring Harbor perspectives in biology 2013 Schuldiner M, Weissman JS
• Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.
  Cell 2013 Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA
• A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility.
  Cell 2013 Bassik MC, Kampmann M, Lebbink RJ, Wang S, Hein MY, Poser I, Weibezahn J, Horlbeck MA, Chen S, Mann M, Hyman AA, Leproust EM, McManus MT, Weissman JS
• Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.
  Genome biology 2013 Muzzey D, Schwartz K, Weissman JS, Sherlock G
• Decoding human cytomegalovirus.
  Science (New York, N.Y.) 2012 Stern-Ginossar N, Weisburd B, Michalski A, Le VT, Hein MY, Huang SX, Ma M, Shen B, Qian SB, Hengel H, Mann M, Ingolia NT, Weissman JS
• A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress.
  Cell 2012 Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman JS
• The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments.
  Nature protocols 2012 Ingolia NT, Brar GA, Rouskin S, McGeachy AM, Weissman JS
• Proto-genes and de novo gene birth.
  Nature 2012 Carvunis AR, Rolland T, Wapinski I, Calderwood MA, Yildirim MA, Simonis N, Charloteaux B, Hidalgo CA, Barbette J, Santhanam B, Brar GA, Weissman JS, Regev A, Thierry-Mieg N, Cusick ME, Vidal M
• Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions.
  Cell 2012 Frost A, Elgort MG, Brandman O, Ives C, Collins SR, Miller-Vedam L, Weibezahn J, Hein MY, Poser I, Mann M, Hyman AA, Weissman JS
• Special issue: the molecular and cellular mechanisms of amyloidosis.
  Journal of molecular biology 2012 Radford SE, Weissman JS
• Native elongating transcript sequencing (NET-seq).
  Current protocols in molecular biology 2012 Churchman LS, Weissman JS
• The anti-Shine-Dalgarno sequence drives translational pausing and codon choice in bacteria.
  Nature 2012 Li GW, Oh E, Weissman JS
• Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae.
  Molecular cell 2012 Stewart-Ornstein J, Weissman JS, El-Samad H
• The translational landscape of mTOR signalling steers cancer initiation and metastasis.
  Nature 2012 Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero D
• High-resolution view of the yeast meiotic program revealed by ribosome profiling.
  Science (New York, N.Y.) 2011 Brar GA, Yassour M, Friedman N, Regev A, Ingolia NT, Weissman JS
• Selective ribosome profiling reveals the cotranslational chaperone action of trigger factor in vivo.
  Cell 2011 Oh E, Becker AH, Sandikci A, Huber D, Chaba R, Gloge F, Nichols RJ, Typas A, Gross CA, Kramer G, Weissman JS, Bukau B
• Genetics: Noise rules.
  Nature 2011 El-Samad H, Weissman JS
• Road to ruin: targeting proteins for degradation in the endoplasmic reticulum.
  Science (New York, N.Y.) 2011 Smith MH, Ploegh HL, Weissman JS
• Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Roelants FM, Breslow DK, Muir A, Weissman JS, Thorner J
• Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes.
  Cell 2011 Ingolia NT, Lareau LF, Weissman JS
• A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria.
  The Journal of cell biology 2011 Hoppins S, Collins SR, Cassidy-Stone A, Hummel E, Devay RM, Lackner LL, Westermann B, Schuldiner M, Weissman JS, Nunnari J
• Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats.
  Nature 2011 Gracheva EO, Cordero-Morales JF, González-Carcacía JA, Ingolia NT, Manno C, Aranguren CI, Weissman JS, Julius D
• H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway.
  Molecular and cellular biology 2011 Terzi N, Churchman LS, Vasiljeva L, Weissman J, Buratowski S
• Strain conformation, primary structure and the propagation of the yeast prion [PSI+].
  Nature structural & molecular biology 2011 Verges KJ, Smith MH, Toyama BH, Weissman JS
• Radically different amyloid conformations dictate the seeding specificity of a chimeric Sup35 prion.
  Journal of molecular biology 2011 Foo CK, Ohhashi Y, Kelly MJ, Tanaka M, Weissman JS
• Nascent transcript sequencing visualizes transcription at nucleotide resolution.
  Nature 2011 Churchman LS, Weissman JS
• Amyloid structure: conformational diversity and consequences.
  Annual review of biochemistry 2011 Toyama BH, Weissman JS
• Systematic screen of Schizosaccharomyces pombe deletion collection uncovers parallel evolution of the phosphate signal transduction pathway in yeasts.
  Eukaryotic cell 2010 Henry TC, Power JE, Kerwin CL, Mohammed A, Weissman JS, Cameron DM, Wykoff DD
• The epistemology of cell biology.
  Molecular biology of the cell 2010 Weissman JS
• Membranes in balance: mechanisms of sphingolipid homeostasis.
  Molecular cell 2010 Breslow DK, Weissman JS
• Mammalian microRNAs predominantly act to decrease target mRNA levels.
  Nature 2010 Guo H, Ingolia NT, Weissman JS, Bartel DP
• Automated identification of pathways from quantitative genetic interaction data.
  Molecular systems biology 2010 Battle A, Jonikas MC, Walter P, Weissman JS, Koller D
• A general lack of compensation for gene dosage in yeast.
  Molecular systems biology 2010 Springer M, Weissman JS, Kirschner MW
• J domain co-chaperone specificity defines the role of BiP during protein translocation.
  The Journal of biological chemistry 2010 Vembar SS, Jonikas MC, Hendershot LM, Weissman JS, Brodsky JL
• Molecular basis of infrared detection by snakes.
  Nature 2010 Gracheva EO, Ingolia NT, Kelly YM, Cordero-Morales JF, Hollopeter G, Chesler AT, Sánchez EE, Perez JC, Weissman JS, Julius D
• Orm family proteins mediate sphingolipid homeostasis.
  Nature 2010 Breslow DK, Collins SR, Bodenmiller B, Aebersold R, Simons K, Shevchenko A, Ejsing CS, Weissman JS
• Differences in prion strain conformations result from non-native interactions in a nucleus.
  Nature chemical biology 2010 Ohhashi Y, Ito K, Toyama BH, Weissman JS, Tanaka M
• Journal club. A biochemist looks at how DNA sequencing can reveal more than just sequences.
  Nature 2009 Weissman J
• From information to knowledge: new technologies for defining gene function.
  Nature methods 2009 Collins SR, Weissman JS, Krogan NJ
• Regulated Ire1-dependent decay of messenger RNAs in mammalian cells.
  The Journal of cell biology 2009 Hollien J, Lin JH, Li H, Stevens N, Walter P, Weissman JS
• An ER-mitochondria tethering complex revealed by a synthetic biology screen.
  Science (New York, N.Y.) 2009 Kornmann B, Currie E, Collins SR, Schuldiner M, Nunnari J, Weissman JS, Walter P
• Rapid creation and quantitative monitoring of high coverage shRNA libraries.
  Nature methods 2009 Bassik MC, Lebbink RJ, Churchman LS, Ingolia NT, Patena W, LeProust EM, Schuldiner M, Weissman JS, McManus MT
• Analysis of Dom34 and its function in no-go decay.
  Molecular biology of the cell 2009 Passos DO, Doma MK, Shoemaker CJ, Muhlrad D, Green R, Weissman J, Hollien J, Parker R
• Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.
  Science (New York, N.Y.) 2009 Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman JS, Schuldiner M
• Functional organization of the S. cerevisiae phosphorylation network.
  Cell 2009 Fiedler D, Braberg H, Mehta M, Chechik G, Cagney G, Mukherjee P, Silva AC, Shales M, Collins SR, van Wageningen S, Kemmeren P, Holstege FC, Weissman JS, Keogh MC, Koller D, Shokat KM, Krogan NJ
• Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling.
  Science (New York, N.Y.) 2009 Ingolia NT, Ghaemmaghami S, Newman JR, Weissman JS
• Defining the glycan destruction signal for endoplasmic reticulum-associated degradation.
  Molecular cell 2008 Quan EM, Kamiya Y, Kamiya D, Denic V, Weibezahn J, Kato K, Weissman JS
• A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing.
  Molecular cell 2008 Wilmes GM, Bergkessel M, Bandyopadhyay S, Shales M, Braberg H, Cagney G, Collins SR, Whitworth GB, Kress TL, Weissman JS, Ideker T, Guthrie C, Krogan NJ
• In vivo monitoring of the prion replication cycle reveals a critical role for Sis1 in delivering substrates to Hsp104.
  Molecular cell 2008 Tipton KA, Verges KJ, Weissman JS
• Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network.
  Nature biotechnology 2008 Chechik G, Oh E, Rando O, Weissman J, Regev A, Koller D
• Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
  Science (New York, N.Y.) 2008 Roguev A, Bandyopadhyay S, Zofall M, Zhang K, Fischer T, Collins SR, Qu H, Shales M, Park HO, Hayles J, Hoe KL, Kim DU, Ideker T, Grewal SI, Weissman JS, Krogan NJ
• High-throughput, quantitative analyses of genetic interactions in E. coli.
  Nature methods 2008 Typas A, Nichols RJ, Siegele DA, Shales M, Collins SR, Lim B, Braberg H, Yamamoto N, Takeuchi R, Wanner BL, Mori H, Weissman JS, Krogan NJ, Gross CA
• Systems biology: Reverse engineering the cell.
  Nature 2008 Ingolia NT, Weissman JS
• The GET complex mediates insertion of tail-anchored proteins into the ER membrane.
  Cell 2008 Schuldiner M, Metz J, Schmid V, Denic V, Rakwalska M, Schmitt HD, Schwappach B, Weissman JS
• A comprehensive strategy enabling high-resolution functional analysis of the yeast genome.
  Nature methods 2008 Breslow DK, Cameron DM, Collins SR, Schuldiner M, Stewart-Ornstein J, Newman HW, Braun S, Madhani HD, Krogan NJ, Weissman JS
• Small-molecule aggregates inhibit amyloid polymerization.
  Nature chemical biology 2008 Feng BY, Toyama BH, Wille H, Colby DW, Collins SR, May BC, Prusiner SB, Weissman J, Shoichet BK
• Identification of yeast proteins necessary for cell-surface function of a potassium channel.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Haass FA, Jonikas M, Walter P, Weissman JS, Jan YN, Jan LY, Schuldiner M
• High-throughput genetic interaction mapping in the fission yeast Schizosaccharomyces pombe.
  Nature methods 2007 Roguev A, Wiren M, Weissman JS, Krogan NJ
• The structural basis of yeast prion strain variants.
  Nature 2007 Toyama BH, Kelly MJ, Gross JD, Weissman JS
• A molecular caliper mechanism for determining very long-chain fatty acid length.
  Cell 2007 Denic V, Weissman JS
• Mec1/Tel1 phosphorylation of the INO80 chromatin remodeling complex influences DNA damage checkpoint responses.
  Cell 2007 Morrison AJ, Kim JA, Person MD, Highland J, Xiao J, Wehr TS, Hensley S, Bao Y, Shen J, Collins SR, Weissman JS, Delrow J, Krogan NJ, Haber JE, Shen X
• Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss.
  Molecular systems biology 2007 Ihmels J, Collins SR, Schuldiner M, Krogan NJ, Weissman JS
• CCR4/NOT complex associates with the proteasome and regulates histone methylation.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Laribee RN, Shibata Y, Mersman DP, Collins SR, Kemmeren P, Roguev A, Weissman JS, Briggs SD, Krogan NJ, Strahl BD
• Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map.
  Nature 2007 Collins SR, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, Schuldiner M, Gebbia M, Recht J, Shales M, Ding H, Xu H, Han J, Ingvarsdottir K, Cheng B, Andrews B, Boone C, Berger SL, Hieter P, Zhang…
• Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae.
  Molecular & cellular proteomics : MCP 2007 Collins SR, Kemmeren P, Zhao XC, Greenblatt JF, Spencer F, Holstege FC, Weissman JS, Krogan NJ
• Quantitative genetic analysis in Saccharomyces cerevisiae using epistatic miniarray profiles (E-MAPs) and its application to chromatin functions.
  Methods (San Diego, Calif.) 2006 Schuldiner M, Collins SR, Weissman JS, Krogan NJ
• Systems biology: many things from one.
  Nature 2006 Newman JR, Weissman JS
• A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation.
  Cell 2006 Denic V, Quan EM, Weissman JS
• Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.
  Science (New York, N.Y.) 2006 Hollien J, Weissman JS
• The physical basis of how prion conformations determine strain phenotypes.
  Nature 2006 Tanaka M, Collins SR, Toyama BH, Weissman JS
• Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise.
  Nature 2006 Newman JR, Ghaemmaghami S, Ihmels J, Breslow DK, Noble M, DeRisi JL, Weissman JS
• Molecular chaperones and protein quality control.
  Cell 2006 Bukau B, Weissman J, Horwich A
• Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
  Nature 2006 Krogan NJ, Cagney G, Yu H, Zhong G, Guo X, Ignatchenko A, Li J, Pu S, Datta N, Tikuisis AP, Punna T, Peregrín-Alvarez JM, Shales M, Zhang X, Davey M, Robinson MD, Paccanaro A, Bray JE, Sheung A, …
• A strategy for extracting and analyzing large-scale quantitative epistatic interaction data.
  Genome biology 2006 Collins SR, Schuldiner M, Krogan NJ, Weissman JS
• An efficient protein transformation protocol for introducing prions into yeast.
  Methods in enzymology 2006 Tanaka M, Weissman JS
• Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.
  Cell 2005 Keogh MC, Kurdistani SK, Morris SA, Ahn SH, Podolny V, Collins SR, Schuldiner M, Chin K, Punna T, Thompson NJ, Boone C, Emili A, Weissman JS, Hughes TR, Strahl BD, Grunstein M, Greenblatt JF, …
• Domain architecture of protein-disulfide isomerase facilitates its dual role as an oxidase and an isomerase in Ero1p-mediated disulfide formation.
  The Journal of biological chemistry 2005 Kulp MS, Frickel EM, Ellgaard L, Weissman JS
• Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile.
  Cell 2005 Schuldiner M, Collins SR, Thompson NJ, Denic V, Bhamidipati A, Punna T, Ihmels J, Andrews B, Boone C, Greenblatt JF, Weissman JS, Krogan NJ
• Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen.
  Molecular cell 2005 Bhamidipati A, Denic V, Quan EM, Weissman JS
• Mechanism of cross-species prion transmission: an infectious conformation compatible with two highly divergent yeast prion proteins.
  Cell 2005 Tanaka M, Chien P, Yonekura K, Weissman JS
• Construction, verification and experimental use of two epitope-tagged collections of budding yeast strains.
  Comparative and functional genomics 2005 Howson R, Huh WK, Ghaemmaghami S, Falvo JV, Bower K, Belle A, Dephoure N, Wykoff DD, Weissman JS, O'Shea EK
• 2004 Irving Sigal Young Investigator Award.
  Protein science : a publication of the Protein Society 2004 Weissman JS, O'Shea EK
• Mechanism of prion propagation: amyloid growth occurs by monomer addition.
  PLoS biology 2004 Collins SR, Douglass A, Vale RD, Weissman JS
• Dissection and design of yeast prions.
  PLoS biology 2004 Osherovich LZ, Cox BS, Tuite MF, Weissman JS
• Conformational variations in an infectious protein determine prion strain differences.
  Nature 2004 Tanaka M, Chien P, Naber N, Cooke R, Weissman JS
• Oxidative protein folding in eukaryotes: mechanisms and consequences.
  The Journal of cell biology 2004 Tu BP, Weissman JS
• Emerging principles of conformation-based prion inheritance.
  Annual review of biochemistry 2004 Chien P, Weissman JS, DePace AH
• Global analysis of protein expression in yeast.
  Nature 2003 Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS
• Global analysis of protein localization in budding yeast.
  Nature 2003 Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, Weissman JS, O'Shea EK
• Generation of prion transmission barriers by mutational control of amyloid conformations.
  Nature 2003 Chien P, DePace AH, Collins SR, Weissman JS
• Directed evolution of substrate-optimized GroEL/S chaperonins.
  Cell 2002 Wang JD, Herman C, Tipton KA, Gross CA, Weissman JS
• The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum.
  Molecular cell 2002 Tu BP, Weissman JS
• Origins and kinetic consequences of diversity in Sup35 yeast prion fibers.
  Nature structural biology 2002 DePace AH, Weissman JS
• The utility of prions.
  Developmental cell 2002 Osherovich LZ, Weissman JS
• Prion diseases. A rogue protein.
  Lancet (London, England) 2001 Weissman JS, Hood JK
• The ins and outs of GroEL-mediated protein folding.
  Molecular cell 2001 Weissman JS
• Preparedness for clinical practice: reports of graduating residents at academic health centers.
  JAMA 2001 Blumenthal D, Gokhale M, Campbell EG, Weissman JS
• Racial differences in cardiac revascularization rates: does "overuse" explain higher rates among white patients?
  Annals of internal medicine 2001 Schneider EC, Leape LL, Weissman JS, Piana RN, Gatsonis C, Epstein AM
• Residents' preferences and preparation for caring for underserved populations.
  Journal of urban health : bulletin of the New York Academy of Medicine 2001 Weissman JS, Campbell EG, Gokhale M, Blumenthal D
• The relationship of market forces to the satisfaction of faculty at academic health centers.
  The American journal of medicine 2001 Blumenthal D, Causino N, Campbell EG, Weissman JS
• Status of clinical research in academic health centers: views from the research leadership.
  JAMA 2001 Campbell EG, Weissman JS, Moy E, Blumenthal D
• Multiple Gln/Asn-rich prion domains confer susceptibility to induction of the yeast [PSI(+)] prion.
  Cell 2001 Osherovich LZ, Weissman JS
• Conformational diversity in a yeast prion dictates its seeding specificity.
  Nature 2001 Chien P, Weissman JS
• The Sar1 GTPase coordinates biosynthetic cargo selection with endoplasmic reticulum export site assembly.
  The Journal of cell biology 2001 Aridor M, Fish KN, Bannykh S, Weissman J, Roberts TH, Lippincott-Schwartz J, Balch WE
• Functional genomic approaches to understanding molecular chaperones and stress responses.
  Advances in protein chemistry 2001 Travers KJ, Patil CK, Weissman JS
• The action of molecular chaperones in the early secretory pathway.
  Annual review of genetics 2001 Fewell SW, Travers KJ, Weissman JS, Brodsky JL
• Understanding the relationship between market competition and students' ratings of the managed care content of their undergraduate medical education.
  Academic medicine : journal of the Association of American Medical Colleges 2001 Campbell EG, Weissman JS, Ausiello J, Wyatt S, Blumenthal D
• Biochemical basis of oxidative protein folding in the endoplasmic reticulum.
  Science (New York, N.Y.) 2000 Tu BP, Ho-Schleyer SC, Travers KJ, Weissman JS
• Racial disparities in access to renal transplantation--clinically appropriate or due to underuse or overuse?
  The New England journal of medicine 2000 Epstein AM, Ayanian JZ, Keogh JH, Noonan SJ, Armistead N, Cleary PD, Weissman JS, David-Kasdan JA, Carlson D, Fuller J, Marsh D, Conti RM
• Unmet health needs of uninsured adults in the United States.
  JAMA 2000 Ayanian JZ, Weissman JS, Schneider EC, Ginsburg JA, Zaslavsky AM
• A census of glutamine/asparagine-rich regions: implications for their conserved function and the prediction of novel prions.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Michelitsch MD, Weissman JS
• Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein.
  Science (New York, N.Y.) 2000 Sparrer HE, Santoso A, Szoka FC, Weissman JS
• Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation.
  Cell 2000 Travers KJ, Patil CK, Wodicka L, Lockhart DJ, Weissman JS, Walter P
• Stage-specific assays to study biosynthetic cargo selection and role of SNAREs in export from the endoplasmic reticulum and delivery to the Golgi.
  Methods (San Diego, Calif.) 2000 Allan BB, Weissman J, Aridor M, Moyer B, Chen CD, Yoo JS, Balch WE
• Molecular basis of a yeast prion species barrier.
  Cell 2000 Santoso A, Chien P, Osherovich LZ, Weissman JS
• Quality of care by race and gender for congestive heart failure and pneumonia.
  Medical care 1999 Ayanian JZ, Weissman JS, Chasan-Taber S, Epstein AM
• The effect of patients' preferences on racial differences in access to renal transplantation.
  The New England journal of medicine 1999 Ayanian JZ, Cleary PD, Weissman JS, Epstein AM
• Academic health centers on the front lines: survival strategies in highly competitive markets.
  Academic medicine : journal of the Association of American Medical Colleges 1999 Blumenthal D, Weissman JS, Griner PF
• Thinking outside the box: new insights into the mechanism of GroEL-mediated protein folding.
  Nature structural biology 1999 Wang JD, Weissman JS
• Hospital readmissions and quality of care.
  Medical care 1999 Weissman JS, Ayanian JZ, Chasan-Taber S, Sherwood MJ, Roth C, Epstein AM
• Market forces and unsponsored research in academic health centers.
  JAMA 1999 Weissman JS, Saglam D, Campbell EG, Causino N, Blumenthal D
• Termination from Medicaid: how does it affect access, continuity of care, and willingness to purchase insurance?
  Journal of health care for the poor and underserved 1999 Weissman JS, Witzburg R, Linov P, Campbell EG
• The stability of preferences for life-sustaining care among persons with AIDS in the Boston Health Study.
  Medical decision making : an international journal of the Society for Medical Decision Making 1999 Weissman JS, Haas JS, Fowler FJ, Gatsonis C, Massagli MP, Seage GR, Cleary P
• GroEL-GroES-mediated protein folding requires an intact central cavity.
  Proceedings of the National Academy of Sciences of the United States of America 1998 Wang JD, Michelitsch MD, Weissman JS
• A critical role for amino-terminal glutamine/asparagine repeats in the formation and propagation of a yeast prion.
  Cell 1998 DePace AH, Santoso A, Hillner P, Weissman JS
• Costs and outcomes of AIDS care: comparing a health maintenance organization with fee-for-service systems in the Boston Health Study.
  Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1998 Wilson IB, Sullivan LM, Weissman JS
• Cargo selection by the COPII budding machinery during export from the ER.
  The Journal of cell biology 1998 Aridor M, Weissman J, Bannykh S, Nuoffer C, Balch WE
• Construction of single-ring and two-ring hybrid versions of bacterial chaperonin GroEL.
  Methods in enzymology 1998 Horwich AL, Burston SG, Rye HS, Weissman JS, Fenton WA
• Ero1p: a novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulum.
  Molecular cell 1998 Pollard MG, Travers KJ, Weissman JS
• Commentary: economic transfers, the changing face of a familiar problem.
  Health services research 1997 Weissman JS
• Deadly conformations--protein misfolding in prion disease.
  Cell 1997 Horwich AL, Weissman JS
• The influence of health-related quality of life and social characteristics on hospital use by patients with AIDS in the Boston Health Study.
  Medical care 1996 Weissman JS, Cleary PD, Seage GR, Gatsonis C, Haas JS, Chasan-Taber S, Epstein AM
• Uncompensated hospital care. Will it be there if we need it?
  JAMA 1996 Weissman J
• Release of both native and non-native proteins from a cis-only GroEL ternary complex.
  Nature 1996 Burston SG, Weissman JS, Farr GW, Fenton WA, Horwich AL
• The validity of self-reported health-care utilization by AIDS patients.
  AIDS (London, England) 1996 Weissman JS, Levin K, Chasan-Taber S, Massagli MP, Seage GR, Scampini L
• Putting a lid on protein folding: structure and function of the co-chaperonin, GroES.
  Chemistry & biology 1996 Fenton WA, Weissman JS, Horwich AL
• Characterization of the active intermediate of a GroEL-GroES-mediated protein folding reaction.
  Cell 1996 Weissman JS, Rye HS, Fenton WA, Beechem JM, Horwich AL
• A kinetic explanation for the rearrangement pathway of BPTI folding.
  Nature structural biology 1995 Weissman JS, Kim PS
• Mechanism of GroEL action: productive release of polypeptide from a sequestered position under GroES.
  Cell 1995 Weissman JS, Hohl CM, Kovalenko O, Kashi Y, Chen S, Braig K, Saibil HR, Fenton WA, Horwich AL
• Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis.
  Journal of molecular biology 1995 Yu MH, Weissman JS, Kim PS
• All roads lead to Rome? The multiple pathways of protein folding.
  Chemistry & biology 1995 Weissman JS
• From the cradle to the grave: ring complexes in the life of a protein.
  Science (New York, N.Y.) 1995 Weissman JS, Sigler PB, Horwich AL
• Costs of medical care and out-of-pocket expenditures for persons with AIDS in the Boston Health Study.
  Inquiry : a journal of medical care organization, provision and financing 1995 Epstein AM, Seage G, Weissman JS, Cleary PD, Fowler FJ, Gatsonis C, Massagli MP, Stone VE, Coltin K, Craven DE
• Kinesis of polypeptide during GroEL-mediated folding.
  Cold Spring Harbor symposia on quantitative biology 1995 Horwich AL, Weissman JS, Fenton WA
• GroEL-mediated protein folding proceeds by multiple rounds of binding and release of nonnative forms.
  Cell 1994 Weissman JS, Kashi Y, Fenton WA, Horwich AL
• Heat shock proteins and molecular chaperones: mediators of protein conformation and turnover in the cell.
  Cell 1994 Craig EA, Weissman JS, Horwich AL
• Utilization of formal and informal home care by AIDS patients in Boston: a comparison of intravenous drug users and homosexual males.
  Medical care 1994 Ettner SL, Weissman J
• Physician discretion and racial variation in the use of surgical procedures.
  Archives of internal medicine 1994 Mort EA, Weissman JS, Epstein AM
• The impact of patient socioeconomic status and other social factors on readmission: a prospective study in four Massachusetts hospitals.
  Inquiry : a journal of medical care organization, provision and financing 1994 Weissman JS, Stern RS, Epstein AM
• Efficient catalysis of disulphide bond rearrangements by protein disulphide isomerase.
  Nature 1993 Weissman JS, Kim PS
• Health-related quality of life in persons with acquired immune deficiency syndrome.
  Medical care 1993 Cleary PD, Fowler FJ, Weissman J, Massagli MP, Wilson I, Seage GR, Gatsonis C, Epstein A
• The pro region of BPTI facilitates folding.
  Cell 1992 Weissman JS, Kim PS
• Rates of avoidable hospitalization by insurance status in Massachusetts and Maryland.
  JAMA 1992 Weissman JS, Gatsonis C, Epstein AM
• Kinetic role of nonnative species in the folding of bovine pancreatic trypsin inhibitor.
  Proceedings of the National Academy of Sciences of the United States of America 1992 Weissman JS, Kim PS
• The emergency department as a pathway to admission for poor and high-cost patients.
  JAMA 1991 Stern RS, Weissman JS, Epstein AM
• Reexamination of the folding of BPTI: predominance of native intermediates.
  Science (New York, N.Y.) 1991 Weissman JS, Kim PS
• Acute aortic thrombosis causing sudden paraplegia in a patient with known thoraco-lumbar spinal metastasis: the diagnostic usefulness of magnetic resonance imaging.
  Neurosurgery 1989 Moore MR, Blatter DD, Weissman J, Tyler HR
• Case mix and resource utilization by uninsured hospital patients in the Boston metropolitan area.
  JAMA 1989 Weissman J, Epstein AM
• Risk factors of drug impairment in random samples of physicians and medical students.
  The International journal of the addictions 1987 McAuliffe WE, Santangelo S, Magnuson E, Sobol A, Rohman M, Weissman J
• Metabolism of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by liver homogenate fractions.
  Journal of medicinal chemistry 1985 Weissman J, Trevor A, Chiba K, Peterson LA, Caldera P, Castagnoli N, Baillie T