Jonathan Singer, MD, MS
Professor
Medicine
School of Medicine

He is the Associate Medical Director of the Advanced Lung Disease and Lung Transplant clinical program and also founded and now co-Directs the UCSF Advanced Lung Disease and Lung Transplant Research Program. The latter is a cross-Departmental group of investigators focused on clinical outcomes, translational, and basic research aimed at addressing the fields' most pressing needs.

Dr. Singer's specific research applies aging-related principles to study patient-centered outcomes in advanced lung disease and lung transplant along three themes: 1) Improving transplant candidate risk stratification by investigating frailty and body composition 2) Patient Centered Outcomes: including functioning, disability, Health-Related Quality of Life (HRQL), and survival

3) Developing and validating novel instruments to measure HRQL, functioning/disability, and frailty for use in advanced lung disease and lung transplantation. The measures he developed - the Lung Transplant Quality of Life scale (LT-QOL), Lung Transplant-Valued Life Activities scale (LT-VLA), the Lung Transplant Frailty Scale (LT-FS), and the Fried Frailty Phenotype-DASI (FFP-DASI) are among the few patient-reported outcome and frailty measures developed specifically for the field.

Dr. Singer received his undergraduate degree from Stanford University. He completed a combined Masters in Health and Medical Sciences from the School of Public Health at UC Berkeley and a medical degree at UCSF as part of the Joint Medical Program. He remained at UCSF, where he completed a residency in Internal Medicine, and fellowships in Pulmonary, Critical Care Medicine, and Lung/Heart-Lung Transplantation. He is board certified in Pulmonary Medicine and Critical Care Medicine. He is a member of the International Society for Heart and Lung transplantation and American Thoracic Society. He is a core investigator with the UCSF Respiratory Epidemiology Group and served as Chair of the International Society of Heart and Lung Transplantation Pulmonary Council Quality of Life Workforce from 2012-2021.

• Macrophage and CD8 T Cell Discordance are Associated with Acute Lung Allograft Dysfunction Progression.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2024 Calabrese DR, Yellamilli S, Ekstrand C, Singer JP, Hays SR, Leard LE, Shah RJ, Venado A, Kolaitis NA, Perez A, Combes A, Greenland JR
• Closing in on Close Connections: A Reply to Thieleman et al.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2024 Prigerson HG, Singer J, Killikelly C
• Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction.
  medRxiv : the preprint server for health sciences 2024 Prather AA, Gao Y, Betancourt L, Kordahl RC, Sriram A, Huang CY, Hays SR, Kukreja J, Calabrese DR, Venado A, Kapse B, Greenland JR, Singer JP
• MICB Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death.
  American journal of respiratory and critical care medicine 2024 Aguilar OA, Qualls AE, Gonzalez-Hinojosa MDR, Obeidalla S, Kerchberger VE, Tsao T, Singer JP, Looney MR, Raymond W, Hays SR, Golden JA, Kukreja J, Shaver CM, Ware LB, Christie J, Diamond JM, Lanier LL…
• The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation.
  American journal of respiratory and critical care medicine 2024 Diamond JM, Cantu E, Calfee CS, Anderson MR, Clausen ES, Shashaty MGS, Courtwright AM, Kalman L, Oyster M, Crespo MM, Bermudez CA, Benvenuto L, Palmer SM, Snyder LD, Hartwig MG, Todd JL, Wille K, Hage…
• Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023 Diamond JM, Anderson MR, Cantu E, Clausen ES, Shashaty MGS, Kalman L, Oyster M, Crespo MM, Bermudez CA, Benvenuto L, Palmer SM, Snyder LD, Hartwig MG, Wille K, Hage C, McDyer JF, Merlo CA, Shah PD, …
• National Prevalence of Social Isolation and Loneliness in Adults with Chronic Obstructive Pulmonary Disease.
  Annals of the American Thoracic Society 2023 Suen AO, Iyer AS, Cenzer I, Farrand E, White DB, Singer J, Sudore R, Kotwal A
• Provider beliefs and practices regarding the management of obesity in lung transplant recipients.
  JHLT open 2023 Diamond JM, Benvenuto L, Claridge T, Witek S, Christie JD, Singer JP, Anderson MR
• CCR5 drives NK cell-associated airway damage in pulmonary ischemia-reperfusion injury.
  JCI insight 2023 Santos J, Wang P, Shemesh A, Liu F, Tsao T, Aguilar OA, Cleary SJ, Singer JP, Gao Y, Hays SR, Golden JA, Leard L, Kleinhenz ME, Kolaitis NA, Shah R, Venado A, Kukreja J, Weigt SS, Belperio JA, Lanier …
• The Role of Palliative Care in Heart Failure, Part 1: Referring Provider Perspectives About Opportunities in Advanced Cardiac Therapies.
  Journal of palliative medicine 2023 Barrett TA, MacEwan SR, Melnyk HL, Volney J, Singer J, Di Tosto G, Rush LJ, Shiu-Yee K, Benza R, McAlearney AS
• The Role of Palliative Care in Heart Failure, Part 3: Facilitators and Barriers to Cardiac Palliative Care Clinic Development.
  Journal of palliative medicine 2023 Barrett TA, MacEwan SR, Melnyk H, Di Tosto G, Rush LJ, Shiu-Yee K, Volney J, Singer J, Benza R, McAlearney AS
• The Role of Palliative Care in Heart Failure, Part 4: A Framework for Collaboration in Advance Care Planning.
  Journal of palliative medicine 2023 Barrett TA, MacEwan SR, Volney J, Singer J, Di Tosto G, Melnyk HL, Shiu-Yee K, Rush LJ, Benza R, McAlearney AS
• Accuracy and Reproducibility of Automated Measurement of Body Composition: A Lung Transplant Body Composition Cohort Study.
  Annals of the American Thoracic Society 2023 Anderson MR, Diamond J, Shashaty M, Singer JP, Tong Y, Udupa J, Torigian DA, Palmer S, Lederer DJ, Christie JD, Al-Naamani N
• Short airway telomeres are associated with primary graft dysfunction and chronic lung allograft dysfunction.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023 Greenland JR, Guo R, Lee S, Tran L, Kapse B, Kukreja J, Hays SR, Golden JA, Calabrese DR, Singer JP, Wolters PJ
• European Respiratory Society statement on frailty in adults with chronic lung disease.
  The European respiratory journal 2023 Osadnik CR, Brighton LJ, Burtin C, Cesari M, Lahousse L, Man WDC, Marengoni A, Sajnic A, Singer JP, Ter Beek L, Tsiligianni I, Varga JT, Pavanello S, Maddocks M
• Efficient electrospray deposition of surfaces smaller than the spray plume.
  Nature communications 2023 Park SH, Lei L, D'Souza D, Zipkin R, DiMartini ET, Atzampou M, Lallow EO, Shan JW, Zahn JD, Shreiber DI, Lin H, Maslow JN, Singer JP
• Decreased Lymphocytic Bronchitis Severity in the Era of Azithromycin Prophylaxis.
  Transplantation direct 2023 Santos J, Hays SR, Golden JA, Calabrese DR, Kolaitis N, Kleinhenz ME, Shah R, Estrada AV, Leard LE, Kukreja J, Singer JP, Greenland JR
• Biofire pneumonia panel in lung donors: faster detection but limited pathogens.
  Transplant infectious disease : an official journal of the Transplantation Society 2023 Nguyen A, Chen J, Isaza E, Panchal N, Deiter F, Hoover J, Trinh B, Hays SR, Golden JA, Singer JP, Brzezinski M, Greenland JR, Kukreja J
• Body Mass Index and Cause-Specific Mortality after Lung Transplantation in the United States.
  Annals of the American Thoracic Society 2023 Anderson MR, Cantu E, Shashaty M, Benvenuto L, Kalman L, Palmer SM, Singer JP, Gallop R, Diamond JM, Hsu J, Localio AR, Christie JD
• Rehabilitation for People with Respiratory Disease and Frailty: An Official American Thoracic Society Workshop Report.
  Annals of the American Thoracic Society 2023 Maddocks M, Brighton LJ, Alison JA, Ter Beek L, Bhatt SP, Brummel NE, Burtin C, Cesari M, Evans RA, Ferrante LE, Flores-Flores O, Franssen FME, Garvey C, Harrison SL, Iyer AS, Lahouse L, Lareau S, Lee…
• What is Frailty?
  American journal of respiratory and critical care medicine 2023 Brighton LJ, Lareau S, Maddocks M, Osadnik C, Lahousse L, Lee A, Allison J, Singer J, Rozenberg D, Man WD, Ferrante L, Spruit MA, Burtin C, Harrison SL, Iyer AS
• Mismatch identified in symptom burden profiles in lung transplantation.
  Heart & lung : the journal of critical care 2023 Koons B, Aryal S, Blumenthal N, Courtwright A, O'Connor M, Christie JD, Singer JP, Riegel B
• Ultra-dense, 1152-core, broadband multicore fiber link deployed in a metro network.
  Optics express 2023 Kopp VI, Park J, Zhang J, Singer J, Neugroschl D, Oda T, Mukai O, Nasir U
• Design and implementation of a digital health home spirometry intervention for remote monitoring of lung transplant function.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023 Odisho AY, Liu AW, Maiorano AR, Bigazzi MOA, Medina E, Leard LE, Shah R, Venado A, Perez A, Golden J, Kleinhenz ME, Kolaitis NA, Maheshwari J, Trinh BN, Kukreja J, Greenland J, Calabrese D, Neinstein …
• Association of Frailty With Health-Related Quality of Life in Liver Transplant Recipients.
  JAMA surgery 2023 Lai JC, Shui AM, Duarte-Rojo A, Rahimi RS, Ganger DR, Verna EC, Volk ML, Kappus M, Ladner DP, Boyarsky B, Segev DL, Gao Y, Huang CY, Singer JP
• The Lung Allocation Score Remains Inequitable for Patients with Pulmonary Arterial Hypertension, Even after the 2015 Revision.
  American journal of respiratory and critical care medicine 2023 Kolaitis NA, Chen H, Calabrese DR, Kumar K, Obata J, Bach C, Golden JA, Simon MA, Kukreja J, Hays SR, Leard LE, Singer JP, De Marco T
• CD16+ natural killer cells in bronchoalveolar lavage are associated with antibody-mediated rejection and chronic lung allograft dysfunction.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 Calabrese DR, Chong T, Singer JP, Rajalingam R, Hays SR, Kukreja J, Leard L, Golden JA, Lanier LL, Greenland JR
• Frailty and genetic risk predict fracture after lung transplantation.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 Macrae TA, Lazo J, Viduya J, Florez R, Dewey K, Gao Y, Singer JP, Hays SR, Golden JA, Kukreja J, Greenland JR, Calabrese DR
• Echocardiographic estimation of pulmonary vascular resistance in advanced lung disease.
  Pulmonary circulation 2023 DesJardin JT, Svetlichnaya Y, Kolaitis NA, Hays SR, Kukreja J, Schiller NB, Zier LS, Singer JP, De Marco T
• NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes.
  JCI insight 2022 Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, …
• Controlling morphology in electrosprayed methylcellulose nanowires via nanoparticle addition: coarse-grained modeling and experiments.
  Nanoscale 2022 Blisko JM, Grzenda MJ, Vladimirsky RM, Shuck CE, Singer JP, Yong X
• Intercostal Nerve Cryoanalgesia Versus Thoracic Epidural Analgesia in Lung Transplantation: A Retrospective Single-Center Study.
  Pain and therapy 2022 Isaza E, Santos J, Haro GJ, Chen J, Weber DJ, Deuse T, Singer JP, Golden JA, Hays S, Trinh BN, Brzezinski M, Kukreja J
• Contemporary trends in PGD incidence, outcomes, and therapies.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2022 Cantu E, Diamond JM, Cevasco M, Suzuki Y, Crespo M, Clausen E, Dallara L, Ramon CV, Harmon MT, Bermudez C, Benvenuto L, Anderson M, Wille KM, Weinacker A, Dhillon GS, Orens J, Shah P, Merlo C, Lama V,…
• Quality of Life Outcomes and Associated Symptoms Reported by Lung Transplant Recipients Amidst COVID-19 Pandemic: Applying a Novel Assessment Tool.
  Transplantation proceedings 2022 Storaasli S, Nakagawa S, Singer JP, Fedoronko DA, Zhang Y, Tsapepas D, Rincon ME, Scheffert J, Benvenuto L, Arcasoy SM
• The Intersection of Aging and Lung Transplantation: its Impact on Transplant Evaluation, Outcomes, and Clinical Care.
  Current transplantation reports 2022 Koons B, Anderson MR, Smith PJ, Greenland JR, Singer JP
• Current Beliefs and Practices Regarding the Management of Obesity in Patients with Progressive Interstitial Lung Disease.
  Annals of the American Thoracic Society 2022 Anderson MR, Aronson KI, Diamond JM, Christie JD, Singer JP
• Depressive symptoms in lung transplant recipients: trajectory and association with mortality and allograft dysfunction.
  Thorax 2022 Kolaitis NA, Gao Y, Soong A, Greenland JR, Hays SR, Golden JA, Venado A, Leard LE, Shah RJ, Kleinhenz ME, Katz PP, Kukreja J, Blanc PD, Smith PJ, Singer JP
• Inflammation on bronchoalveolar lavage cytology is associated with decreased chronic lung allograft dysfunction-free survival.
  Clinical transplantation 2022 Greenland NY, Deiter F, Calabrese DR, Hays SR, Kukreja J, Leard LE, Kolaitis NA, Golden JA, Singer JP, Greenland JR
• ADAM8 signaling drives neutrophil migration and ARDS severity.
  JCI insight 2022 Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet…
• Lung transplant recipients with idiopathic pulmonary fibrosis have impaired alloreactive immune responses.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2021 Wang P, Leung J, Lam A, Lee S, Calabrese DR, Hays SR, Golden JA, Kukreja J, Singer JP, Wolters PJ, Tang Q, Greenland JR
• Novel suction-based in vivo cutaneous DNA transfection platform.
  Science advances 2021 Lallow EO, Jhumur NC, Ahmed I, Kudchodkar SB, Roberts CC, Jeong M, Melnik JM, Park SH, Muthumani K, Shan JW, Zahn JD, Shreiber DI, Singer JP, Park YK, Maslow JN, Lin H
• Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction.
  Frontiers in immunology 2021 Dugger DT, Calabrese DR, Gao Y, Deiter F, Tsao T, Maheshwari J, Hays SR, Leard L, Kleinhenz ME, Shah R, Golden J, Kukreja J, Gordon ED, Singer JP, Greenland JR
• Construct and Predictive Validity of Sarcopenia in Lung Transplant Candidates.
  Annals of the American Thoracic Society 2021 Maheshwari JA, Kolaitis NA, Anderson MR, Benvenuto L, Gao Y, Katz PP, Greenland J, Wolters PJ, Covinsky K, Hays SR, Kukreja J, Calabrese DR, Venado A, Shah RJ, Leard LE, Trinh B, Huang CY, Glidden D, …
• Lung Transplantation for Patients With COVID-19.
  Chest 2021 King CS, Mannem H, Kukreja J, Aryal S, Tang D, Singer JP, Bharat A, Behr J, Nathan SD
• Thermocapillary dewetting-based dynamic spatial light modulator.
  Optics letters 2021 Kovacevich DA, Ma T, Gamboa AR, Nitzsche MP, Saro-Cortes V, Davis E, Singer JP
• Clinical Differences and Outcomes between Methamphetamine-associated and Idiopathic Pulmonary Arterial Hypertension in the Pulmonary Hypertension Association Registry.
  Annals of the American Thoracic Society 2021 Kolaitis NA, Zamanian RT, de Jesus Perez VA, Badesch DB, Benza RL, Burger CD, Chakinala MM, Elwing JM, Feldman J, Lammi MR, Mathai SC, McConnell JW, Presberg KW, Robinson JC, Sager J, Shlobin OA, …
• The association of post-operative delirium with patient-reported outcomes and mortality after lung transplantation.
  Clinical transplantation 2021 DeBolt CL, Gao Y, Sutter N, Soong A, Leard L, Jeffrey G, Kleinhenz ME, Calabrese D, Greenland J, Venado A, Hays SR, Shah R, Kukreja J, Trinh B, Kolaitis NA, Douglas V, Diamond JM, Smith P, Singer J
• Lung transplantation from swimming pool drowning victims: A case series.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2021 Tsou S, Chen J, Brzezinski M, Hays S, Leard L, Singer JP, Trinh B, Kukreja J
• Rapid molecular detection of airway pathogens in lung transplant recipients.
  Transplant infectious disease : an official journal of the Transplantation Society 2021 Hoover J, Mintz MA, Deiter F, Aminian E, Chen J, Hays SR, Singer JP, Calabrese DR, Kukreja J, Greenland JR
• Mobile health technology to improve emergent frailty after lung transplantation.
  Clinical transplantation 2021 Diamond JM, Courtwright AM, Balar P, Oyster M, Zaleski D, Adler J, Brown M, Hays SR, Sutter N, Garvey C, Kukreja J, Gao Y, Bruun A, Smith PJ, Singer JP
• Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury.
  The Journal of clinical investigation 2021 Calabrese DR, Aminian E, Mallavia B, Liu F, Cleary SJ, Aguilar OA, Wang P, Singer JP, Hays SR, Golden JA, Kukreja J, Dugger D, Nakamura M, Lanier LL, Looney MR, Greenland JR
• Risk of primary graft dysfunction following lung transplantation in selected adults with connective tissue disease-associated interstitial lung disease.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2021 Natalini JG, Diamond JM, Porteous MK, Lederer DJ, Wille KM, Weinacker AB, Orens JB, Shah PD, Lama VN, McDyer JF, Snyder LD, Hage CA, Singer JP, Ware LB, Cantu E, Oyster M, Kalman L, Christie JD, Kawut…
• Frailty and aging-associated syndromes in lung transplant candidates and recipients.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Schaenman JM, Diamond JM, Greenland JR, Gries C, Kennedy CC, Parulekar AD, Rozenberg D, Singer JP, Singer LG, Snyder LD, Bhorade S
• Type-1 immunity and endogenous immune regulators predominate in the airway transcriptome during chronic lung allograft dysfunction.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Iasella CJ, Hoji A, Popescu I, Wei J, Snyder ME, Zhang Y, Xu W, Iouchmanov V, Koshy R, Brown M, Fung M, Langelier C, Lendermon EA, Dugger D, Shah R, Lee J, Johnson B, Golden J, Leard LE, Ellen …
• Complement activation on endothelium initiates antibody-mediated acute lung injury.
  The Journal of clinical investigation 2020 Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR
• Self-limiting electrospray deposition on polymer templates.
  Scientific reports 2020 Lei L, Gamboa AR, Kuznetsova C, Littlecreek S, Wang J, Zou Q, Zahn JD, Singer JP
• Chronic lung allograft dysfunction small airways reveal a lymphocytic inflammation gene signature.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Dugger DT, Fung M, Hays SR, Singer JP, Kleinhenz ME, Leard LE, Golden JA, Shah RJ, Lee JS, Deiter F, Greenland NY, Jones KD, Langelier CR, Greenland JR
• Primary graft dysfunction attenuates improvements in health-related quality of life after lung transplantation, but not disability or depression.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Kolaitis NA, Gao Y, Soong A, Greenland JR, Hays SR, Golden J, Leard LE, Shah RJ, Kleinhenz ME, Katz PP, Venado A, Kukreja J, Blanc PD, Singer JP
• Cystic Fibrosis Lung Transplant Recipients Have Suppressed Airway Interferon Responses during Pseudomonas Infection.
  Cell reports. Medicine 2020 Dugger DT, Fung M, Zlock L, Caldera S, Sharp L, Hays SR, Singer JP, Leard LE, Golden JA, Shah RJ, Kukreja J, Gordon E, Finkbeiner W, Kleinhenz ME, Langelier C, Greenland JR
• Skeletal muscle adiposity and outcomes in candidates for lung transplantation: a lung transplant body composition cohort study.
  Thorax 2020 Anderson MR, Easthausen I, Gallagher G, Udupa J, Tong Y, Torigian D, Diamond JM, Porteous MK, Palmer SM, Snyder LD, Benvenuto L, Aversa M, Arcasoy S, Greenland JR, Hays SR, Kukreja J, Cantu E, Kim JS,…
• Ingenol mebutate 0·015% gel is safe for short-term treatment of actinic keratoses on the face in solid organ transplant recipients.
  The British journal of dermatology 2020 Crow LD, Yuan JT, Aroyan CS, Twigg AR, Singer JP, Roll GR, Lazar AA, Arron ST
• Risk Factors and Outcomes of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation.
  Seminars in thoracic and cardiovascular surgery 2020 Kukreja J, Tsou S, Chen J, Trinh BN, Feng C, Golden JA, Hays S, Deuse T, Singer JP, Brzezinski M
• Frailty after lung transplantation is associated with impaired health-related quality of life and mortality.
  Thorax 2020 Venado A, Kolaitis NA, Huang CY, Gao Y, Glidden DV, Soong A, Sutter N, Katz PP, Greenland JR, Calabrese DR, Hays SR, Golden JA, Shah RJ, Leard LE, Kukreja J, Deuse T, Wolters PJ, Covinsky K, Blanc PD,…
• Pathobiology of frailty in lung disease.
  Translational research : the journal of laboratory and clinical medicine 2020 Koons B, Greenland JR, Diamond JM, Singer JP
• Improvements in frailty contribute to substantial improvements in quality of life after lung transplantation in patients with cystic fibrosis.
  Pediatric pulmonology 2020 Perez AA, Hays SR, Soong A, Gao Y, Greenland JR, Leard LE, Shah RJ, Golden J, Kukreja J, Venado A, Kleinhenz ME, Singer JP
• Improved survival after lung transplantation for adults requiring preoperative invasive mechanical ventilation: A national cohort study.
  The Journal of thoracic and cardiovascular surgery 2020 Hamilton BCS, Dincheva GR, Matthay MA, Hays S, Singer JP, Brzezinski M, Kukreja J
• Mitochondrial DNA Stimulates TLR9-Dependent Neutrophil Extracellular Trap Formation in Primary Graft Dysfunction.
  American journal of respiratory cell and molecular biology 2020 Mallavia B, Liu F, Lefrançais E, Cleary SJ, Kwaan N, Tian JJ, Magnen M, Sayah DM, Soong A, Chen J, Saggar R, Shino MY, Ross DJ, Derhovanessian A, Lynch JP, Ardehali A, Weigt SS, Belperio JA, Hays SR, …
• Tacrolimus trough monitoring guided by mass spectrometry without accounting for assay differences is associated with acute kidney injury in lung transplant recipients.
  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2019 Kolaitis NA, Calabrese DR, Ahearn P, Venado A, Florez R, Lei HL, Isaak K, Henricksen E, Martinez E, Chong T, Shah RJ, Leard LE, Kleinhenz ME, Golden J, De Marco T, Greenland JR, Kukreja J, Hays SR, …
• Dectin-1 genetic deficiency predicts chronic lung allograft dysfunction and death.
  JCI insight 2019 Calabrese DR, Wang P, Chong T, Hoover J, Singer JP, Torgerson D, Hays SR, Golden JA, Kukreja J, Dugger D, Christie JD, LTOG investigators, Greenland JR
• Frailty and the Burden of Concurrent and Incident Disability in Patients With Cirrhosis: A Prospective Cohort Study.
  Hepatology communications 2019 Lai JC, Dodge JL, McCulloch CE, Covinsky KE, Singer JP
• Initial skin cancer screening for solid organ transplant recipients in the United States: Delphi method development of expert consensus guidelines.
  Transplant international : official journal of the European Society for Organ Transplantation 2019 Crow LD, Jambusaria-Pahlajani A, Chung CL, Baran DA, Lowenstein SE, Abdelmalek M, Ahmed RL, Anadkat MJ, Arcasoy SM, Berg D, Bibee KP, Billingsley E, Black WH, Blalock TW, Bleicher M, Brennan DC, …
• Discharge frailty following lung transplantation.
  Clinical transplantation 2019 Courtwright AM, Zaleski D, Tevald M, Adler J, Singer JP, Cantu EE, A Bermudez C, Diamond JM
• Transplantation in the Face of Donor-Specific Antibodies: A Pathway to Become Better.
  Annals of the American Thoracic Society 2019 Kolaitis NA, Singer JP
• Adipose tissue quantification and primary graft dysfunction after lung transplantation: The Lung Transplant Body Composition study.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2019 Anderson MR, Udupa JK, Edwin E, Diamond JM, Singer JP, Kukreja J, Hays SR, Greenland JR, Ferrante A, Lippel M, Blue T, McBurnie A, Oyster M, Kalman L, Rushefski M, Wu C, Pednekar G, Liu W, Arcasoy S, …
• A nonlinear relationship between visceral adipose tissue and frailty in adult lung transplant candidates.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2019 Anderson MR, Kolaitis NA, Gao Y, Kukreja J, Greenland J, Hays S, Wolters P, Golden J, Diamond J, Palmer S, Arcasoy S, Udupa J, Christie JD, Lederer DJ, Singer JP
• Management and clinical outcomes after lung transplantation in patients with pre-transplant Mycobacterium abscessus infection: A single center experience.
  Transplant infectious disease : an official journal of the Transplantation Society 2019 Perez AA, Singer JP, Schwartz BS, Chin-Hong P, Shah RJ, Kleinhenz ME, Gao Y, Venado A, Leard LE, Golden JA, Kukreja J, Greenland JR, Hays SR
• Gene signatures common to allograft rejection are associated with lymphocytic bronchitis.
  Clinical transplantation 2019 Greenland JR, Wang P, Brotman JJ, Ahuja R, Chong TA, Kleinhenz ME, Leard LE, Golden JA, Hays SR, Kukreja J, Singer JP, Rajalingam R, Jones K, Laszik ZG, Trivedi NN, Greenland NY, Blanc PD
• Frailty trajectories in adult lung transplantation: A cohort study.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2019 Venado A, McCulloch C, Greenland JR, Katz P, Soong A, Shrestha P, Hays S, Golden J, Shah R, Leard LE, Kleinhenz ME, Kukreja J, Zablotska L, Allen IE, Covinsky K, Blanc P, Singer JP
• NKG2C Natural Killer Cells in Bronchoalveolar Lavage Are Associated With Cytomegalovirus Viremia and Poor Outcomes in Lung Allograft Recipients.
  Transplantation 2019 Calabrese DR, Chong T, Wang A, Singer JP, Gottschall M, Hays SR, Golden JA, Kukreja J, Lanier LL, Tang Q, Greenland JR
• Report from the American Society of Transplantation on frailty in solid organ transplantation.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2018 Kobashigawa J, Dadhania D, Bhorade S, Adey D, Berger J, Bhat G, Budev M, Duarte-Rojo A, Dunn M, Hall S, Harhay MN, Johansen KL, Joseph S, Kennedy CC, Kransdorf E, Lentine KL, Lynch RJ, McAdams-DeMarco…
• National Heart, Lung, and Blood Institute and American Association for Thoracic Surgery Workshop Report: Identifying collaborative clinical research priorities in lung transplantation.
  The Journal of thoracic and cardiovascular surgery 2018 Mulligan MS, Weill D, Davis RD, Christie JD, Farjah F, Singer JP, Hartwig M, Sanchez PG, Kreisel D, Ware LB, Bermudez C, Hachem RR, Weyant MJ, Gries C, Awori Hayanga JW, Griffith BP, Snyder LD, Odim J…
• The 2018 ISHLT/APM/AST/ICCAC/STSW Recommendations for the Psychosocial Evaluation of Adult Cardiothoracic Transplant Candidates and Candidates for Long-term Mechanical Circulatory Support.
  Psychosomatics 2018 Dew MA, DiMartini AF, Dobbels F, Grady KL, Jowsey-Gregoire SG, Kaan A, Kendall K, Young QR, Abbey SE, Butt Z, Crone CC, De Geest S, Doligalski CT, Kugler C, McDonald L, Ohler L, Painter L, Petty MG, …
• Genotypes associated with tacrolimus pharmacokinetics impact clinical outcomes in lung transplant recipients.
  Clinical transplantation 2018 Calabrese DR, Florez R, Dewey K, Hui C, Torgerson D, Chong T, Faust H, Rajalingam R, Hays SR, Golden JA, Kukreja J, Singer JP, Greenland JR
• A mobile health technology enabled home-based intervention to treat frailty in adult lung transplant candidates: A pilot study.
  Clinical transplantation 2018 Singer JP, Soong A, Bruun A, Bracha A, Chin G, Hays SR, Kukreja J, Rigler J, Golden JA, Greenland JR, Garvey C
• Low dose posaconazole delayed release tablets for fungal prophylaxis in lung transplant recipients.
  Clinical transplantation 2018 Kozuch JM, Feist A, Yung G, Awdishu L, Hays S, Singer JP, Florez R
• Suppressed calcineurin-dependent gene expression identifies lung allograft recipients at increased risk of infection.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2018 Greenland JR, Chong T, Wang AS, Martinez E, Shrestha P, Kukreja J, Hays SR, Golden JA, Singer JP, Tang Q
• Frailty phenotypes and mortality after lung transplantation: A prospective cohort study.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2018 Singer JP, Diamond JM, Anderson MR, Katz PP, Covinsky K, Oyster M, Blue T, Soong A, Kalman L, Shrestha P, Arcasoy SM, Greenland JR, Shah L, Kukreja J, Blumenthal NP, Easthausen I, Golden JA, McBurnie …
• The 2018 ISHLT/APM/AST/ICCAC/STSW recommendations for the psychosocial evaluation of adult cardiothoracic transplant candidates and candidates for long-term mechanical circulatory support.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2018 Dew MA, DiMartini AF, Dobbels F, Grady KL, Jowsey-Gregoire SG, Kaan A, Kendall K, Young QR, Abbey SE, Butt Z, Crone CC, De Geest S, Doligalski CT, Kugler C, McDonald L, Ohler L, Painter L, Petty MG, …
• Defining Success in Lung Transplantation: From Survival to Quality of Life.
  Seminars in respiratory and critical care medicine 2018 Kolaitis NA, Singer JP
• Elevated donor plasminogen activator inhibitor-1 levels and the risk of primary graft dysfunction.
  Clinical transplantation 2018 Hamilton BCS, Dincheva GR, Zhuo H, Golden JA, Brzezinski M, Singer JP, Matthay MA, Kukreja J
• Improvement in patient-reported outcomes after lung transplantation is not impacted by the use of extracorporeal membrane oxygenation as a bridge to transplantation.
  The Journal of thoracic and cardiovascular surgery 2018 Kolaitis NA, Soong A, Shrestha P, Zhuo H, Neuhaus J, Katz PP, Greenland JR, Golden J, Leard LE, Shah RJ, Hays SR, Kukreja J, Kleinhenz ME, Blanc PD, Singer JP
• Moving Pulmonary Rehabilitation Into the Home: A CLINICAL REVIEW.
  Journal of cardiopulmonary rehabilitation and prevention 2018 Garvey C, Singer JP, Bruun AM, Soong A, Rigler J, Hays S
• Pulmonary Hypertension and Primary Graft Dysfunction in Lung Transplant Recipients: We Still Have a Long Way to Go.
  Annals of the American Thoracic Society 2017 Singer JP
• Frailty and maximal exercise capacity in adult lung transplant candidates.
  Respiratory medicine 2017 Layton AM, Armstrong HF, Baldwin MR, Podolanczuk AJ, Pieszchata NM, Singer JP, Arcasoy SM, Meza KS, D'Ovidio F, Lederer DJ
• Refining Low Physical Activity Measurement Improves Frailty Assessment in Advanced Lung Disease and Survivors of Critical Illness.
  Annals of the American Thoracic Society 2017 Baldwin MR, Singer JP, Huang D, Sell J, Gonzalez WC, Pollack LR, Maurer MS, D'Ovidio FF, Bacchetta M, Sonett JR, Arcasoy SM, Shah L, Robbins H, Hays SR, Kukreja J, Greenland JR, Shah RJ, Leard L, …
• Report of the International Society for Heart and Lung Transplantation Working Group on Primary Lung Graft Dysfunction, part II: Epidemiology, risk factors, and outcomes-A 2016 Consensus Group statement of the International Society for Heart and Lung Transplantation.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2017 Diamond JM, Arcasoy S, Kennedy CC, Eberlein M, Singer JP, Patterson GM, Edelman JD, Dhillon G, Pena T, Kawut SM, Lee JC, Girgis R, Dark J, Thabut G
• HLA Mismatching Favoring Host-Versus-Graft NK Cell Activity Via KIR3DL1 Is Associated With Improved Outcomes Following Lung Transplantation.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2017 Greenland JR, Sun H, Calabrese D, Chong T, Singer JP, Kukreja J, Hays SR, Golden JA, Caughey GH, Venstrom JM, Rajalingam R
• Short lung transplant donor telomere length is associated with decreased CLAD-free survival.
  Thorax 2017 Faust HE, Golden JA, Rajalingam R, Wang AS, Green G, Hays SR, Kukreja J, Singer JP, Wolters PJ, Greenland JR
• Donor-Reactive Regulatory T Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts.
  Transplantation 2016 Greenland JR, Wong CM, Ahuja R, Wang AS, Uchida C, Golden JA, Hays SR, Leard LE, Rajalingam R, Singer JP, Kukreja J, Wolters PJ, Caughey GH, Tang Q
• Frailty in Pulmonary and Critical Care Medicine.
  Annals of the American Thoracic Society 2016 Singer JP, Lederer DJ, Baldwin MR
• Trends of skin cancer mortality after transplantation in the United States: 1987 to 2013.
  Journal of the American Academy of Dermatology 2016 Garrett GL, Lowenstein SE, Singer JP, He SY, Arron ST
• Prolonged Barium-Impaction Ileus in Two Lung Transplant Recipients With Systemic Sclerosis: Case Report.
  Transplantation proceedings 2015 Tokman S, Hays SR, Leard LE, Bush EL, Kukreja J, Kleinhenz ME, Golden JA, Singer JP
• Voriconazole Exposure and Risk of Cutaneous Squamous Cell Carcinoma, Aspergillus Colonization, Invasive Aspergillosis and Death in Lung Transplant Recipients.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2015 Mansh M, Binstock M, Williams K, Hafeez F, Kim J, Glidden D, Boettger R, Hays S, Kukreja J, Golden J, Asgari MM, Chin-Hong P, Singer JP, Arron ST
• Lung transplantation for hypersensitivity pneumonitis.
  Chest 2015 Kern RM, Singer JP, Koth L, Mooney J, Golden J, Hays S, Greenland J, Wolters P, Ghio E, Jones KD, Leard L, Kukreja J, Blanc PD
• Clinical outcomes of lung transplant recipients with telomerase mutations.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2015 Tokman S, Singer JP, Devine MS, Westall GP, Aubert JD, Tamm M, Snell GI, Lee JS, Goldberg HJ, Kukreja J, Golden JA, Leard LE, Garcia CK, Hays SR
• Practice variation in Aspergillus prophylaxis and treatment among lung transplant centers: a national survey.
  Transplant infectious disease : an official journal of the Transplantation Society 2015 He SY, Makhzoumi ZH, Singer JP, Chin-Hong PV, Arron ST
• Defining novel health-related quality of life domains in lung transplantation: a qualitative analysis.
  Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 2014 Singer JP, Chen J, Katz PP, Blanc PD, Kagawa-Singer M, Stewart AL
• Belatacept for Maintenance Immunosuppression in Lung Transplantation.
  Journal of investigative medicine high impact case reports 2014 Hui C, Kern R, Wojciechowski D, Kukreja J, Golden JA, Hays SR, Singer JP
• The feasibility of lung transplantation in HIV-seropositive patients.
  Annals of the American Thoracic Society 2014 Kern RM, Seethamraju H, Blanc PD, Sinha N, Loebe M, Golden J, Kukreja J, Scheinin S, Hays S, Kleinhenz ME, Leard L, Hoopes C, Singer JP
• Lung Transplantation for Scleroderma-related Lung Disease.
  Current respiratory care reports 2014 Richardson CB, Singer JP
• A randomized trial of the effects of nebulized albuterol on pulmonary edema in brain-dead organ donors.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2014 Ware LB, Landeck M, Koyama T, Zhao Z, Singer J, Kern R, Neidlinger N, Nguyen J, Johnson E, Janz DR, Bernard GR, Lee JW, Matthay MA, California Transplant Donor Network
• Bronchoalveolar lavage cell immunophenotyping facilitates diagnosis of lung allograft rejection.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2014 Greenland JR, Jewell NP, Gottschall M, Trivedi NN, Kukreja J, Hays SR, Singer JP, Golden JA, Caughey GH
• Use of Belatacept in a Lung Transplant Recipient
  J Invest Med High Impact Case Reports 2014 Hui C, Kern RM, Wojciechowski D, Kukreja J, Golden JA, Hays SR, Singer JP.
• Voriconazole-associated cutaneous malignancy: a literature review on photocarcinogenesis in organ transplant recipients.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2013 Williams K, Mansh M, Chin-Hong P, Singer J, Arron ST
• Quality of life in lung transplantation.
  Seminars in respiratory and critical care medicine 2013 Singer JP, Singer LG
• Outcomes in systemic sclerosis-related lung disease after lung transplantation.
  Transplantation 2013 Sottile PD, Iturbe D, Katsumoto TR, Connolly MK, Collard HR, Leard LA, Hays S, Golden JA, Hoopes C, Kukreja J, Singer JP
• A thematic analysis of quality of life in lung transplant: the existing evidence and implications for future directions.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013 Singer JP, Chen J, Blanc PD, Leard LE, Kukreja J, Chen H
• Scedosporium prolificans pericarditis and mycotic aortic aneurysm in a lung transplant recipient receiving voriconazole prophylaxis.
  Transplant infectious disease : an official journal of the Transplantation Society 2013 Sayah DM, Schwartz BS, Kukreja J, Singer JP, Golden JA, Leard LE
• Rhinovirus and other respiratory viruses exert different effects on lung allograft function that are not mediated through acute rejection.
  Clinical transplantation 2012 Sayah DM, Koff JL, Leard LE, Hays SR, Golden JA, Singer JP
• Defining patient-reported outcomes in chronic obstructive pulmonary disease: the patient-centered experience.
  The Medical clinics of North America 2012 Singer JP, Yusen RD
• Both pulmonary and extra-pulmonary factors predict the development of disability in chronic obstructive pulmonary disease.
  Respiration; international review of thoracic diseases 2012 Singer JP, Katz PP, Iribarren C, Omachi TA, Sanchez G, Yelin EH, Cisternas MG, Blanc PD
• Relationship of obesity with respiratory symptoms and decreased functional capacity in adults without established COPD.
  Primary care respiratory journal : journal of the General Practice Airways Group 2012 Zutler M, Singer JP, Omachi TA, Eisner M, Iribarren C, Katz P, Blanc PD
• High cumulative dose exposure to voriconazole is associated with cutaneous squamous cell carcinoma in lung transplant recipients.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2012 Singer JP, Boker A, Metchnikoff C, Binstock M, Boettger R, Golden JA, Glidden DV, Arron ST
• Cytomegalovirus disease and infection in lung transplant recipients in the setting of planned indefinite valganciclovir prophylaxis.
  Transplant infectious disease : an official journal of the Transplantation Society 2012 Wiita AP, Roubinian N, Khan Y, Chin-Hong PV, Singer JP, Golden JA, Miller S
• The 7th edition AJCC staging system for cutaneous squamous cell carcinoma accurately predicts risk of recurrence for heart and lung transplant recipients.
  Journal of the American Academy of Dermatology 2012 Metchnikoff C, Mully T, Singer JP, Golden JA, Arron ST
• Use of sublingual tacrolimus in lung transplant recipients.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2011 Watkins KD, Boettger RF, Hanger KM, Leard LE, Golden JA, Hoopes CW, Singer JP
• An analysis of potential risk factors for early complications from fiberoptic bronchoscopy in lung transplant recipients.
  Transplant international : official journal of the European Society for Organ Transplantation 2011 Smith L, Singer JP, Hayes M, Golden JA, Leard LE
• Survival following lung transplantation for silicosis and other occupational lung diseases.
  Occupational medicine (Oxford, England) 2011 Singer JP, Chen H, Phelan T, Kukreja J, Golden JA, Blanc PD
• The impact of pretransplant mechanical ventilation on short- and long-term survival after lung transplantation.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011 Singer JP, Blanc PD, Hoopes C, Golden JA, Koff JL, Leard LE, Cheng S, Chen H
• Respiratory and skeletal muscle strength in chronic obstructive pulmonary disease: impact on exercise capacity and lower extremity function.
  Journal of cardiopulmonary rehabilitation and prevention 2011 Singer J, Yelin EH, Katz PP, Sanchez G, Iribarren C, Eisner MD, Blanc PD
• Catastrophic squamous cell carcinoma in lung transplant patients treated with voriconazole.
  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 2010 Ibrahim SF, Singer JP, Arron ST
• The impact of a "low-intensity" versus "high-intensity" medical intensive care unit on patient outcomes in critically ill veterans.
  Journal of intensive care medicine 2010 Singer JP, Kohlwes J, Bent S, Zimmerman L, Eisner MD
• Supratherapeutic anticoagulation from low-molecular-weight heparin in lung transplant recipients.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2010 Singer JP, Huang MY, Hui C, Blanc PD, Boettger RF, Golden J, Watkins K, Hoopes C, Leard LE
• Vascular endothelial growth factor and basic fibroblast growth factor expression in esophageal adenocarcinoma and Barrett esophagus.
  The Journal of thoracic and cardiovascular surgery 2003 Lord RV, Park JM, Wickramasinghe K, DeMeester SR, Oberg S, Salonga D, Singer J, Peters JH, Danenberg KD, Demeester TR, Danenberg PV
• Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival.
  Oncogene 2001 Brabender J, Usadel H, Danenberg KD, Metzger R, Schneider PM, Lord RV, Wickramasinghe K, Lum CE, Park J, Salonga D, Singer J, Sidransky D, Hölscher AH, Meltzer SJ, Danenberg PV