Jonathan Pan, PhD, MD
Associate Professor
Anesthesia
School of Medicine

Awards

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• John Severinghaus Assistant Professor, Anesthesia, UCSF, 2014-2016

Education & Training

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• MD. Medicine Fudan University Medical Center
• PhD. Neuroscience Rutgers University
• NIH T32 Fellow Anesthesia and Neurotrauma University of California
• Resident Anesthesiology and Critical Care University of Pennsylvania

Websites

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• Labspot (ucsf.labspot.io)
• Pan lab at UCSF Anesthesia (anesthesia.ucsf.edu)

Grants and Projects

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• Role of Activating Transcription Factor 3 in Spinal Cord Injury, Department of Defense, 2022-2025

Publications (38)

Top publication keywords:
DexmedetomidineHalothaneProteogenomicsNeuroprotective AgentsAdrenergic alpha-2 Receptor AgonistsSpinal Cord InjuriesGene Regulatory NetworksRecovery of FunctionAnesthetics, Inhalationrho-Associated KinasesArterial PressureIsofluraneProtein BiosynthesisProtein Interaction MappingReceptors, Adrenergic, alpha-2

• Correction: Expert-augmented automated machine learning optimizes hemodynamic predictors of spinal cord injury outcome.
  PloS one 2023 Chou A, Torres-Espin A, Kyritsis N, Huie JR, Khatry S, Funk J, Hay J, Lofgreen A, Shah R, McCann C, Pascual LU, Amorim E, Weinstein PR, Manley GT, Dhall SS, Pan JZ, Bresnahan JC, Beattie MS, Whetstone…
• 188 American Spinal Injury Association (ASIA) Impairment Scale (AIS) Conversion Underestimates Neurological Recovery Following Traumatic Spinal Cord Injury.
  Neurosurgery 2023 Winward Choy, Nikolaos Kyritsis, Xuan Duong Fernandez, Adam Ferguson, Debra P. Hemmerle, Lisa U. Pascual, Vineeta Singh, Jason Talbott, Jonathan Pan, Abel Torres, William Whetstone, J. Russell Huie, …
• Hypotension requiring vasopressor treatment and increased cardiac complications in elderly spinal cord injury patients: a prospective TRACK-SCI registry study.
  Journal of neurosurgery. Spine 2023 Agarwal N, Blitstein J, Lui A, Torres-Espin A, Vasnarungruengkul C, Burke J, Mummaneni PV, Dhall SS, Weinstein PR, Duong-Fernandez X, Chou A, Pan J, Singh V, Ferguson AR, Hemmerle DD, Kyritsis N, …
• Editorial: Perinatal hypoxic-ischemic brain injury: Mechanisms, pathogenesis, and potential therapeutic strategies. Front Cell Neurosci. 2022 Dec 13;16:1086692. PMID: 36582212
  Editorial: Perinatal hypoxic-ischemic brain injury: Mechanisms, pathogenesis, and potential therapeutic strategies. Front Cell Neurosci. 2022 Dec 13;16:1086692. PMID: 36582212 2022 Xiaodi Chen, Shadi Nawaf Malaeb, Jonathan Pan, Laishuan Wang, Joseph Scafidi
• Expert-augmented automated machine learning optimizes hemodynamic predictors of spinal cord injury outcome.
  PloS one 2022 Chou A, Torres-Espin A, Kyritsis N, Huie JR, Khatry S, Funk J, Hay J, Lofgreen A, Shah R, McCann C, Pascual LU, Amorim E, Weinstein PR, Manley GT, Dhall SS, Pan JZ, Bresnahan JC, Beattie MS, Whetstone…

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• Decision tree-based machine learning analysis of intraoperative vasopressor use to optimize neurological improvement in acute spinal cord injury.
  Neurosurgical focus 2022 Agarwal N, Aabedi AA, Torres-Espin A, Chou A, Wozny TA, Mummaneni PV, Burke JF, Ferguson AR, Kyritsis N, Dhall SS, Weinstein PR, Duong-Fernandez X, Pan J, Singh V, Hemmerle DD, Talbott JF, Whetstone …
• Topological network analysis of patient similarity for precision management of acute blood pressure in spinal cord injury.
  eLife 2021 Torres-Espín A, Haefeli J, Ehsanian R, Torres D, Almeida CA, Huie JR, Chou A, Morozov D, Sanderson N, Dirlikov B, Suen CG, Nielson JL, Kyritsis N, Hemmerle DD, Talbott JF, Manley GT, Dhall SS, …
• Diagnostic blood RNA profiles for human acute spinal cord injury.
  The Journal of experimental medicine 2021 Kyritsis N, Torres-Espín A, Schupp PG, Huie JR, Chou A, Duong-Fernandez X, Thomas LH, Tsolinas RE, Hemmerle DD, Pascual LU, Singh V, Pan JZ, Talbott JF, Whetstone WD, Burke JF, DiGiorgio AM, Weinstein…
• Injury volume extracted from MRI predicts neurologic outcome in acute spinal cord injury: A prospective TRACK-SCI pilot study.
  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2020 Mummaneni N, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris M, Pascual LU, Ferguson AR, Russell Huie J, Pan JZ, Hemmerle DD, Singh V, Torres-Espin A, Omondi C, Kyritsis N, Weinstein PR, …
• Dexmedetomidine Exerts an Anti-inflammatory Effect via α2 Adrenoceptors to Prevent Lipopolysaccharide-induced Cognitive Decline in Mice.
  Anesthesiology 2020 Li R, Lai IK, Pan JZ, Zhang P, Maze M
• Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI): an overview of initial enrollment and demographics.
  Neurosurgical focus 2020 Tsolinas RE, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris MH, Yue JK, Winkler EA, Suen CG, Pascual LU, Ferguson AR, Huie JR, Pan JZ, Hemmerle DD, Singh V, Torres-Espin A, Omondi C, …
• Dexmedetomidine modulates neuroinflammation and improves outcome via alpha2-adrenergic receptor signaling after rat spinal cord injury.
  British journal of anaesthesia 2019 Gao J, Sun Z, Xiao Z, Du Q, Niu X, Wang G, Chang YW, Sun Y, Sun W, Lin A, Bresnahan JC, Maze M, Beattie MS, Pan JZ
• Traumatic Brain Injury: Risk Assessment and Perioperative Management.
  2019 Jonathan Z. Pan, Lingzhong Meng
• Clinical Implementation of Novel Spinal Cord Perfusion Pressure Protocol in Acute Traumatic Spinal Cord Injury at U.S. Level I Trauma Center: TRACK-SCI Study.
  World neurosurgery 2019 Yue JK, Hemmerle DD, Winkler EA, Thomas LH, Fernandez XD, Kyritsis N, Pan JZ, Pascual LU, Singh V, Weinstein PR, Talbott JF, Huie JR, Ferguson AR, Whetstone WD, Manley GT, Beattie MS, Bresnahan JC, …
• In Reply: Ultra-Early (<12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury.
  Neurosurgery 2019 Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott JF, Pan JZ, Ferguson AR, Beattie MS, Bresnahan JC, Haefeli J, Whetstone WD, Suen CG, Huang MC, Manley GT, Tarapore PE, Dhall SS
• Ultra-Early (<12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury.
  Neurosurgery 2019 Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott JF, Pan JZ, Ferguson AR, Beattie MS, Bresnahan JC, Haefeli J, Whetstone WD, Suen CG, Huang MC, Manley GT, Tarapore PE, Dhall SS
• Motor Evoked Potentials Correlate With Magnetic Resonance Imaging and Early Recovery After Acute Spinal Cord Injury.
  Neurosurgery 2018 Dhall SS, Haefeli J, Talbott JF, Ferguson AR, Readdy WJ, Bresnahan JC, Beattie MS, Pan JZ, Manley GT, Whetstone WD
• Genomics and Proteomic Techniques.
  Methods in enzymology 2018 Pan JZ
• Between a ROCK and an IR Place.
  Anesthesia and analgesia 2018 Pan JZ, Eckenhoff RG
• Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury.
  Neurosurgery 2016 Readdy WJ, Saigal R, Whetstone WD, Mefford AN, Ferguson AR, Talbott JF, Inoue T, Bresnahan JC, Beattie MS, Pan J, Manley GT, Dhall SS
• Anesthesia for Electroconvulsive Therapy.
  2016 Nicole Jackman, Jonathan Z. Pan
• Higher Mean Arterial Pressure Values Correlate with Neurologic Improvement in Patients with Initially Complete Spinal Cord Injuries.
  World neurosurgery 2016 Catapano JS, John Hawryluk GW, Whetstone W, Saigal R, Ferguson A, Talbott J, Bresnahan J, Dhall S, Pan J, Beattie M, Manley G
• 182 Ultra-Early (<12 Hours) Decompression Improves Recovery After Spinal Cord Injury Compared to Early (12-24 Hours) Decompression.
  Neurosurgery 2016 Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott J, Pan J, Ferguson A, Beattie M, Bresnahan J, Haefeli J, Whetstone W, Suen C, Huang MC, Manley GT, Tarapore PE, Dhall SS
• 182 Ultra-Early (<12 Hours) Decompression Improves Recovery After Spinal Cord Injury Compared to Early (12-24 Hours) Decompression.
  Neurosurgery 2016 John Frederick Burke, John K. Yue, Laura Benjamin Ngwenya, Ethan A. Winkler, Jason Talbott, Jonathan Pan, Adam Ferguson, Michael Beattie, Jacqueline Bresnahan, Jenny Haefeli, William Whetstone, …
• Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury.
  Neurosurgery 2016 Readdy WJ, Saigal R, Whetstone WD, Mefford A, Ferguson AR, Talbott JF, Inoue T, Bresnahan JC, Beattie MS, Pan J, Manley GT, Dhall SS
• Changes in the Bispectral Index in Response to Loss of Consciousness and No Somatic Movement to Nociceptive Stimuli in Elderly Patients.
  Chinese medical journal 2016 Yang N, Yue Y, Pan JZ, Zuo MZ, Shi Y, Zhou SZ, Peng WP, Gao JD
• Multidimensional Analysis of Magnetic Resonance Imaging Predicts Early Impairment in Thoracic and Thoracolumbar Spinal Cord Injury.
  Journal of neurotrauma 2016 Mabray MC, Talbott JF, Whetstone WD, Dhall SS, Phillips DB, Pan JZ, Manley GT, Bresnahan JC, Beattie MS, Haefeli J, Ferguson AR
• Mean Arterial Blood Pressure Correlates with Neurological Recovery after Human Spinal Cord Injury: Analysis of High Frequency Physiologic Data.
  Journal of neurotrauma 2015 Hawryluk G, Whetstone W, Saigal R, Ferguson A, Talbott J, Bresnahan J, Dhall S, Pan J, Beattie M, Manley G
• Complications and outcomes of vasopressor usage in acute traumatic central cord syndrome.
  Journal of neurosurgery. Spine 2015 Readdy WJ, Whetstone WD, Ferguson AR, Talbott JF, Inoue T, Saigal R, Bresnahan JC, Beattie MS, Pan JZ, Manley GT, Dhall SS
• The Brain and Spinal Injury Center score: a novel, simple, and reproducible method for assessing the severity of acute cervical spinal cord injury with axial T2-weighted MRI findings.
  Journal of neurosurgery. Spine 2015 Talbott JF, Whetstone WD, Readdy WJ, Ferguson AR, Bresnahan JC, Saigal R, Hawryluk GW, Beattie MS, Mabray MC, Pan JZ, Manley GT, Dhall SS
• Differential general anesthetic effects on microglial cytokine expression.
  PloS one 2013 Ye X, Lian Q, Eckenhoff MF, Eckenhoff RG, Pan JZ
• Inhaled anesthetics elicit region-specific changes in protein expression in mammalian brain.
  Proteomics 2008 Pan JZ, Xi J, Eckenhoff MF, Eckenhoff RG
• Limitations of microarray studies.
  Anesthesia and analgesia 2007 Pan JZ, Eckenhoff RG, Eckenhoff MF
• Halothane binding proteome in human brain cortex.
  Journal of proteome research 2007 Pan JZ, Xi J, Tobias JW, Eckenhoff MF, Eckenhoff RG
• Rat brain DNA transcript profile of halothane and isoflurane exposure.
  Pharmacogenetics and genomics 2006 Pan JZ, Wei H, Hecker JG, Tobias JW, Eckenhoff RG, Eckenhoff MF
• Screening anti-inflammatory compounds in injured spinal cord with microarrays: a comparison of bioinformatics analysis approaches.
  Physiological genomics 2004 Pan JZ, Jörnsten R, Hart RP
• Cytokine activity contributes to induction of inflammatory cytokine mRNAs in spinal cord following contusion.
  Journal of neuroscience research 2002 Pan JZ, Ni L, Sodhi A, Aguanno A, Young W, Hart RP
• Pathological CNS autoimmune disease triggered by traumatic spinal cord injury: implications for autoimmune vaccine therapy.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 Jones TB, Basso DM, Sodhi A, Pan JZ, Hart RP, MacCallum RC, Lee S, Whitacre CC, Popovich PG