Jonathan Li, MD, MS
RESIDENT
Surgery
School of Medicine

(Po-Yi) Jonathan Li is a first-year general surgery resident at UCSF. He completed his B.A. at the University of California, Berkeley where he studied Molecular and Cell Biology with a focus in immunology. He spent 2 years developing non-viral CRISPR gene editing and screening technologies to improve cancer cell therapies before attending medical school at the University of California, San Francisco.

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During medical school, he took a funded research year to study predictive risk models for HCC waitlist and transplant outcomes and concurrently completed a Master’s in Clinical and Epidemiologic Research.

Awards

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• Long Term Dean's Prize Finalist, UCSF, 2024
• Early Career Investigator Award in Clinical/Translational Science, AASLD, 2023
• TL1 Blue Ribbon Award, ACTS, 2023
• Burroughs Wellcome Fund Trainee Travel Award, Burroughs Wellcome Fund, 2023
• UCSF Yearlong Research Fellowship, UCSF, 2022-2023

Education & Training

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• MAS Clinical and Epidemiologic Research University of California, San Francisco 05/2024
• MD Medicine University of California, San Francisco 05/2024
• BA Molecular and Cell Biology University of California, Berkeley 05/2017

Publications (13)

Top publication keywords:
Gene Knock-In TechniquesTissue and Organ Procurementalpha-FetoproteinsCRISPR-Cas SystemsCarcinoma, HepatocellularMelanoma, ExperimentalMacrophage Colony-Stimulating FactorGene EditingCellular ReprogrammingGenetic EngineeringLiver NeoplasmsT-LymphocytesProthrombinGenome, HumanLiver Transplantation

• A Computer Vision Algorithm to Predict Superior Mesenteric Artery Margin Status for Patients with Pancreatic Ductal Adenocarcinoma.
  Annals of surgery 2024 Wang J, Ashraf Ganjouei A, Romero-Hernandez F, Foroutani L, Bahceci D, Deranteriassian A, Casey M, Li PY, Houshmand S, Behr S, Jamshidi N, Majumdar S, Donahue T, Kim GE, Wang ZJ, Thornblade LW, Adam M…
• Recent Advances in Liver Transplantation for Hepatocellular Carcinoma.
  Current treatment options in oncology 2024 Li PJ, Shah S, Mehta N
• Development and validation of a biomarker index for HCC treatment response.
  Hepatology communications 2024 Liang J, Li PY, Norman J, Lauzon M, Yeo YH, Trivedi H, Ayoub WS, Kuo A, Friedman ML, Sankar K, Gong J, Osipov A, Hendifar A, Todo T, Kim I, Voidonikolas G, Brennan TV, Wisel SA, Steggarda J, Kosari K,…
• AFP-L3 and DCP strongly predict early hepatocellular carcinoma recurrence after liver transplantation.
  Journal of hepatology 2023 Norman JS, Li PJ, Kotwani P, Shui AM, Yao F, Mehta N
• AFP-L3 and DCP are superior to AFP in predicting waitlist dropout in HCC patients: Results of a prospective study.
  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2023 Mehta N, Kotwani P, Norman J, Shui A, Li PJ, Saxena V, Chan W, Yao FY

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• Hospital-Based Donor Recruitment and Predonation Serologic Testing for COVID-19 Convalescent Plasma.
  American journal of clinical pathology 2021 Balcerek J, Trejo E, Levine K, Couey P, Kornberg ZV, Rogine C, Young C, Li PJ, Shy BR, Taylor JE, Bakhtary S, Friedlander T, Lynch KL, Bern C, Esensten JH
• Bioinformatic Approaches to Validation and Functional Analysis of 3D Lung Cancer Models.
  Cancers 2021 Li PJ, Roose JP, Jablons DM, Kratz JR
• Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies.
  Cell 2020 Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A
• Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency.
  Nature biotechnology 2019 Nguyen DN, Roth TL, Li PJ, Chen PA, Apathy R, Mamedov MR, Vo LT, Tobin VR, Goodman D, Shifrut E, Bluestone JA, Puck JM, Szoka FC, Marson A
• Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function.
  Cell 2018 Shifrut E, Carnevale J, Tobin V, Roth TL, Woo JM, Bui CT, Li PJ, Diolaiti ME, Ashworth A, Marson A
• Reprogramming human T cell function and specificity with non-viral genome targeting.
  Nature 2018 Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta…
• Tumor-derived CSF-1 induces the NKG2D ligand RAE-1d on tumor-infiltrating macrophages.
  eLife 2018 Thompson TW, Jackson BT, Li PJ, Wang J, Kim AB, Huang KTH, Zhang L, Raulet DH
• Endothelial cells express NKG2D ligands and desensitize antitumor NK responses.
  eLife 2017 Thompson TW, Kim AB, Li PJ, Wang J, Jackson BT, Huang KTH, Zhang L, Raulet DH