Jonathan Budzik, MD, PhD
Assistant Professor
Medicine
School of Medicine

Education & Training

Show all (5) Hide

• Diversity, Equity, and Inclusion Champion Training University of California 2020
• Pulmonary and Critical Care Medicine Fellowship University of California 2017
• Internal Medicine Residency University of California 2014
• MD Medicine University of Chicago 2011
• PhD Microbiology University of Chicago 2009

Publications (25)

Top publication keywords:
Cell WallCysteine EndopeptidasesBacterial ProteinsImmunocompetenceGram-Positive BacteriaNocardia InfectionsAminoacyltransferasesFimbriae ProteinsBacillus cereusMycobacterium tuberculosisFimbriae, BacterialTuberculosisPyrazinamideBacillus anthracisAmides

• Author Correction: Autophagy restricts Mycobacterium tuberculosis during acute infection in mice.
  Nature microbiology 2024 Golovkine GR, Roberts AW, Morrison HM, Rivera-Lugo R, McCall RM, Nilsson H, Garelis NE, Repasy T, Cronce M, Budzik J, Van Dis E, Popov LM, Mitchell G, Zalpuri R, Jorgens D, Cox JS
• History of tuberculosis disease is associated with genetic regulatory variation in Peruvians.
  PLoS genetics 2024 Nieto-Caballero VE, Reijneveld JF, Ruvalcaba A, Innocenzi G, Abeydeera N, Asgari S, Lopez K, Iwany SK, Luo Y, Nathan A, Fernandez-Salinas D, Chiñas M, Huang CC, Zhang Z, León SR, Calderon RI, Lecca L,…
• Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.
  PLoS pathogens 2024 Zheng W, Chang IC, Limberis J, Budzik JM, Zha BS, Howard Z, Chen L, Ernst JD
• Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.
  Research square 2023 Zheng W, Chang IC, Limberis J, Budzik J, Zha BS, Howard Z, Chen L, Ernst J
• Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.
  bioRxiv : the preprint server for biology 2023 Zheng W, Chang IC, Limberis J, Budzik JM, Zha BS, Howard Z, Chen L, Ernst JD

Show all (20 more) Hide

• Autophagy restricts Mycobacterium tuberculosis during acute infection in mice.
  Nature microbiology 2023 Golovkine GR, Roberts AW, Morrison HM, Rivera-Lugo R, McCall RM, Nilsson H, Garelis NE, Repasy T, Cronce M, Budzik J, Van Dis E, Popov LM, Mitchell G, Zalpuri R, Jorgens D, Cox JS
• Ceragenins and Antimicrobial Peptides Kill Bacteria through Distinct Mechanisms.
  mBio 2022 Mitchell G, Silvis MR, Talkington KC, Budzik JM, Dodd CE, Paluba JM, Oki EA, Trotta KL, Licht DJ, Jimenez-Morales D, Chou S, Savage PB, Gross CA, Marletta MA, Cox JS
• Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins.
  Cell reports 2021 Hiatt J, Cavero DA, McGregor MJ, Zheng W, Budzik JM, Roth TL, Haas KM, Wu D, Rathore U, Meyer-Franke A, Bouzidi MS, Shifrut E, Lee Y, Kumar VE, Dang EV, Gordon DE, Wojcechowskyj JA, Hultquist JF, …
• Antibiotic adverse reactions in adult cystic fibrosis patients.
  The journal of allergy and clinical immunology. In practice 2020 Anstey KM, Lee M, Dawson D, Jue V, Budzik JM, Yu M, Kleinhenz ME, Otani IM
• Dynamic post-translational modification profiling of Mycobacterium tuberculosis-infected primary macrophages.
  eLife 2020 Budzik JM, Swaney DL, Jimenez-Morales D, Johnson JR, Garelis NE, Repasy T, Roberts AW, Popov LM, Parry TJ, Pratt D, Ideker T, Krogan NJ, Cox JS
• Pyrazinamide resistance, Mycobacterium tuberculosis lineage and treatment outcomes in San Francisco, California.
  PloS one 2014 Budzik JM, Jarlsberg LG, Higashi J, Grinsdale J, Hopewell PC, Kato-Maeda M, Nahid P
• Isopeptide bonds of the major pilin protein BcpA influence pilus structure and bundle formation on the surface of Bacillus cereus.
  Molecular microbiology 2012 Hendrickx AP, Poor CB, Jureller JE, Budzik JM, He C, Schneewind O
• Disseminated Nocardia farcinica: literature review and fatal outcome in an immunocompetent patient.
  Surgical infections 2012 Budzik JM, Hosseini M, Mackinnon AC, Taxy JB
• Two capsular polysaccharides enable Bacillus cereus G9241 to cause anthrax-like disease.
  Molecular microbiology 2011 Oh SY, Budzik JM, Garufi G, Schneewind O
• Architects at the bacterial surface - sortases and the assembly of pili with isopeptide bonds.
  Nature reviews. Microbiology 2011 Hendrickx AP, Budzik JM, Oh SY, Schneewind O
• Intramolecular amide bonds stabilize pili on the surface of bacilli.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Budzik JM, Poor CB, Faull KF, Whitelegge JP, He C, Schneewind O
• Sortase D forms the covalent bond that links BcpB to the tip of Bacillus cereus pili.
  The Journal of biological chemistry 2009 Budzik JM, Oh SY, Schneewind O
• Capsule anchoring in Bacillus anthracis occurs by a transpeptidation reaction that is inhibited by capsidin.
  Molecular microbiology 2008 Richter S, Anderson VJ, Garufi G, Lu L, Budzik JM, Joachimiak A, He C, Schneewind O, Missiakas D
• Cell wall anchor structure of BcpA pili in Bacillus anthracis.
  The Journal of biological chemistry 2008 Budzik JM, Oh SY, Schneewind O
• Sortases make pili from three ingredients.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Oh SY, Budzik JM, Schneewind O
• Amide bonds assemble pili on the surface of bacilli.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Budzik JM, Marraffini LA, Souda P, Whitelegge JP, Faull KF, Schneewind O
• Assembly of pili on the surface of Bacillus cereus vegetative cells.
  Molecular microbiology 2007 Budzik JM, Marraffini LA, Schneewind O
• Pili prove pertinent to enterococcal endocarditis.
  The Journal of clinical investigation 2006 Budzik JM, Schneewind O
• Isolation and characterization of a generalized transducing phage for Pseudomonas aeruginosa strains PAO1 and PA14.
  Journal of bacteriology 2004 Budzik JM, Rosche WA, Rietsch A, O'Toole GA
• The role of bacterial biofilms in ocular infections.
  DNA and cell biology 2002 Zegans ME, Becker HI, Budzik J, O'Toole G