Joline Fan, MD, MS
Assistant Professor
Neurology
School of Medicine

Awards

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• AES Young Investigator Award, American Epilepsy Society (AES), 2022

Education & Training

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• B.S.E. Chemical and Biological Engineering Princeton University
• M.S. Bioengineering Stanford University
• Fellowship Epilepsy University of California San Francisco
• M.D. Medicine University of California San Francisco
• Residency Neurology University of California San Francisco

Grants and Projects

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• Network dynamics of sleep-wake states in epilepsy, NIH/NINDS, 2023-2027
• Mapping Corticolimbic Circuitry of Arousal Using Intracranial Electrophysiology, Brain & Behavior Research Foundation NARSAD Young Investigator Grant, 2023-2025
• , Doris Duke Charitable Foundation (Physician Scientist Fellowship), 2021-2023
• , CTSI TL1 Post-doctoral Fellowship Training Program, 2020-2021

Publications (33)

Top publication keywords:
ElectroencephalographyBrain-Computer InterfacesInpatientsEpilepsyNeural ProsthesesObsessive-Compulsive DisorderDeep Brain StimulationStatus EpilepticusPsoriasisArthritis, PsoriaticSeizuresArousalWakefulnessElectrocorticographyMemory

• Intracranial beta activity is a biomarker of circadian and stimulation-induced arousal in obsessive compulsive disorder.
  Brain stimulation 2023 Fan JM, De B, Frank AC, Basich-Pease G, Norbu T, Morrison MA, Larson P, Starr PA, Krystal AD, Lee AM
• Cortical Synchrony and Information Flow during Transition from Wakefulness to Light Non-Rapid Eye Movement Sleep.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Fan JM, Kudo K, Verma P, Ranasinghe KG, Morise H, Findlay AM, Vossel K, Kirsch HE, Raj A, Krystal AD, Nagarajan SS
• Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder.
  Journal of visualized experiments : JoVE 2023 Sellers KK, Khambhati AN, Stapper N, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD
• Intracranial electrical stimulation of corticolimbic sites modulates arousal in humans.
  Brain stimulation 2023 Fan JM, Lee AM, Sellers KK, Woodworth K, Makhoul GS, Liu TX, Henderson C, Astudillo Maya DA, Martinez R, Zamanian H, Speidel BA, Khambhati AN, Rao VR, Sugrue LP, Scangos KW, Chang EF, Krystal AD
• Closed-loop neurostimulation for the treatment of psychiatric disorders.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2023 Sellers KK, Cohen JL, Khambhati AN, Fan JM, Lee AM, Chang EF, Krystal AD

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• 46. Amygdala-Hippocampus Coherence is a Biomarker of Predominant Symptom Sets in Patients With Depression.
  Biological Psychiatry 2023 Joshua Cohen, Joline M. Fan, Kristin K. Sellers, Ankit N. Khambhati, Heather E. Dawes, Katherine W. Scangos, Vikram R. Rao, Leo P. Sugrue, Philip A. Starr, Edward F. Chang, Andrew D. Krystal
• 468. Correspondence Between fMRI and Electrophysiological Functional Connectivity in Treatment-Resistant Depression.
  Biological Psychiatry 2023 Niki Sabetfakhri, Joline Fan, Natalya Slepneva, Julian Motzkin, Melanie Morrison, Leo Sugrue, Kristin Sellers, Andrew Krystal, A Moses Lee
• Epileptiform discharges triggered with direct electrical stimulation for treatment-resistant depression: Factors that modulate risk and treatment considerations.
  Brain stimulation 2023 Fan JM, Khambhati AN, Sellers KK, Stapper N, Maya DA, Kunwar E, Henderson C, Sugrue LP, Scangos KW, Chang EF, Rao VR, Krystal AD
• Changes in intracranial neurophysiology associated with acute COVID-19 infection.
  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2023 Sellers KK, Stapper N, Astudillo Maya DA, Henderson C, Khambhati AN, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD
• BNST beta power is associated with diurnal variations in wakefulness and DBS-induced arousal in patients with severe OCD.
  Brain Stimulation 2023 Bianca De, Joline Fan, A Moses Lee
• Correspondence in network connectivity assessed using fMRI and intracranial recordings in patients with severe refractory depression.
  Brain Stimulation 2023 Niki Sabetfakhri, Joline Fan, Natalya Slepneva, Julian Motkzin, Melanie Morrison, Leo Sugrue, Andrew Krystal, A Moses Lee
• Modern intracranial electroencephalography for epilepsy localization with combined subdural grid and depth electrodes with low and improved hemorrhagic complication rates.
  Journal of neurosurgery 2022 Lee AT, Nichols NM, Speidel BA, Fan JM, Cajigas I, Knowlton RC, Chang EF
• Network connectivity predicts effectiveness of responsive neurostimulation in focal epilepsy.
  Brain communications 2022 Fan JM, Lee AT, Kudo K, Ranasinghe KG, Morise H, Findlay AM, Kirsch HE, Chang EF, Nagarajan SS, Rao VR
• Management of Status Epilepticus and Indications for Inpatient Electroencephalography Monitoring.
  Neurologic clinics 2022 Fan JM, Singhal NS, Guterman EL
• Bilateral temporal lobe epilepsy: How many seizures are required in chronic ambulatory electrocorticography to estimate the laterality ratio?
  Epilepsia 2021 Chiang S, Fan JM, Rao VR
• 073 Whole-brain network analysis of neural oscillations during light sleep.
  Sleep 2021 Joline Fan, Kiwamu Kudo, Kamalini Ranasinghe, Hirofumi Morise, Anne Findlay, Heidi Kirsch, Andrew Krystal, Srikantan Nagarajan
• Seizure Cycles in Focal Epilepsy.
  JAMA neurology 2021 Leguia MG, Andrzejak RG, Rummel C, Fan JM, Mirro EA, Tcheng TK, Rao VR, Baud MO
• Evidence for long memory in focal seizure duration.
  Epilepsia open 2021 Fan JM, Chiang S, Rao VR
• Data-Driven, Visual Framework for the Characterization of Aphasias Across Stroke, Post-resective, and Neurodegenerative Disorders Over Time.
  Frontiers in neurology 2020 Fan JM, Gorno-Tempini ML, Dronkers NF, Miller BL, Berger MS, Chang EF
• Balancing Hemorrhage Risk with Electrode Coverage.
  Neurosurgery 2020 Anthony T Lee, Noah M.L Nichols, Benjamin Speidel, Joline Fan, Robert C Knowlton, Edward F Chang
• Catastrophic stroke burden in a patient with uncontrolled psoriasis and psoriatic arthritis: a case report.
  BMC neurology 2020 Fan JM, Solomon DA, López GY, Hofmann JW, Colorado RA, Kim AS, Meisel K, Halabi C
• Characterization of Multidien Rhythms in Patients with Epilepsy (S36.007).
  Neurology 2019 Joline M. Fan, Maxime O. Baud, Vikram R. Rao
• Performance sustaining intracortical neural prostheses.
  Journal of neural engineering 2014 Nuyujukian P, Kao JC, Fan JM, Stavisky SD, Ryu SI, Shenoy KV
• A high-performance keyboard neural prosthesis enabled by task optimization.
  IEEE transactions on bio-medical engineering 2014 Nuyujukian P, Fan JM, Kao JC, Ryu SI, Shenoy KV
• Intention estimation in brain-machine interfaces.
  Journal of neural engineering 2014 Fan JM, Nuyujukian P, Kao JC, Chestek CA, Ryu SI, Shenoy KV
• A high-performance neural prosthesis enabled by control algorithm design.
  Nature neuroscience 2012 Gilja V, Nuyujukian P, Chestek CA, Cunningham JP, Yu BM, Fan JM, Churchland MM, Kaufman MT, Kao JC, Ryu SI, Shenoy KV
• A recurrent neural network for closed-loop intracortical brain-machine interface decoders.
  Journal of neural engineering 2012 Sussillo D, Nuyujukian P, Fan JM, Kao JC, Stavisky SD, Ryu S, Shenoy K
• A brain machine interface control algorithm designed from a feedback control perspective.
  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2012 Gilja V, Nuyujukian P, Chestek CA, Cunningham JP, Yu BM, Fan JM, Ryu SI, Shenoy KV
• Characterizing tumor heterogeneity with functional imaging and quantifying high-risk tumor volume for early prediction of treatment outcome: cervical cancer as a model.
  International journal of radiation oncology, biology, physics 2011 Mayr NA, Huang Z, Wang JZ, Lo SS, Fan JM, Grecula JC, Sammet S, Sammet CL, Jia G, Zhang J, Knopp MV, Yuh WT
• Therapy Outcome Prediction of Cervical Cancer with the Regression Rate of Physiologic High-risk Tumor Subvolume Assessed by DCE MRI.
  International Journal of Radiation Oncology • Biology • Physics 2011 N.A. Mayr, Z. Huang, S.S. Lo, G. Jia, J.C. Grecula, J. Zhang, J.M. Fan, M.V. Knopp, W.T.C. Yuh
• Long-term stability of neural prosthetic control signals from silicon cortical arrays in rhesus macaque motor cortex.
  Journal of neural engineering 2011 Chestek CA, Gilja V, Nuyujukian P, Foster JD, Fan JM, Kaufman MT, Churchland MM, Rivera-Alvidrez Z, Cunningham JP, Ryu SI, Shenoy KV
• Monkey models for brain-machine interfaces: the need for maintaining diversity.
  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2011 Nuyujukian P, Fan JM, Gilja V, Kalanithi PS, Chestek CA, Shenoy KV
• Quantifying Absolute Functional Risk Volume with Functional Tumor Imaging for Treatment Outcome Prediction in Cervical Cancer.
  International Journal of Radiation Oncology • Biology • Physics 2010 N.A. Mayr, J.Z. Wang, Z. Huang, S.S. Lo, J.M. Fan, J.C. Grecula, S. Sammet, C.L. Tosti, M.V. Knopp, W.T.C. Yuh