Johnathon Lakins, PhD
Specialist
Surgery
School of Medicine

Publications (21)

Top publication keywords:
Extracellular MatrixSynaptic MembranesHuman Embryonic Stem CellsLow Density Lipoprotein Receptor-Related Protein-2MesodermAcrylic ResinsGerm LayersCollagenElasticityStress, MechanicalCell Culture TechniquesEmbryonic Stem CellsGastrulationCell DifferentiationAmnion

• Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.
  Nature medicine 2024 Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA…
• Expression of Concern: α6β4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-κB-dependent resistance to apoptosis in 3D mammary acini.
  Journal of cell science 2023 Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM
• Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells.
  bioRxiv : the preprint server for biology 2023 Ayad NME, Lakins JN, Ghagre A, Ehrlicher AJ, Weaver VM
• A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer.
  Nature communications 2023 Stashko C, Hayward MK, Northey JJ, Pearson N, Ironside AJ, Lakins JN, Oria R, Goyette MA, Mayo L, Russnes HG, Hwang ES, Kutys ML, Polyak K, Weaver VM
• Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer.
  The Journal of experimental medicine 2021 Drain AP, Zahir N, Northey JJ, Zhang H, Huang PJ, Maller O, Lakins JN, Yu X, Leight JL, Alston-Mills BP, Hwang ES, Chen YY, Park CC, Weaver VM

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• Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression.
  Nature materials 2020 Maller O, Drain AP, Barrett AS, Borgquist S, Ruffell B, Zakharevich I, Pham TT, Gruosso T, Kuasne H, Lakins JN, Acerbi I, Barnes JM, Nemkov T, Chauhan A, Gruenberg J, Nasir A, Bjarnadottir O, Werb Z, …
• Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells.
  Developmental cell 2020 Muncie JM, Ayad NME, Lakins JN, Xue X, Fu J, Weaver VM
• Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics.
  Journal of visualized experiments : JoVE 2019 Muncie JM, Falcón-Banchs R, Lakins JN, Sohn LL, Weaver VM
• Controlled modelling of human epiblast and amnion development using stem cells.
  Nature 2019 Zheng Y, Xue X, Shao Y, Wang S, Esfahani SN, Li Z, Muncie JM, Lakins JN, Weaver VM, Gumucio DL, Fu J
• Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation.
  Cell stem cell 2016 Przybyla L, Lakins JN, Weaver VM
• Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.
  Nature medicine 2016 Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA…
• A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype.
  Journal of biotechnology 2014 Cassereau L, Miroshnikova YA, Ou G, Lakins J, Weaver VM
• Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression.
  Nature medicine 2014 Mouw JK, Yui Y, Damiano L, Bainer RO, Lakins JN, Acerbi I, Ou G, Wijekoon AC, Levental KR, Gilbert PM, Hwang ES, Chen YY, Weaver VM
• A physical sciences network characterization of non-tumorigenic and metastatic cells.
  Scientific reports 2013 Physical Sciences - Oncology Centers Network, Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, …
• Exploring the link between human embryonic stem cell organization and fate using tension-calibrated extracellular matrix functionalized polyacrylamide gels.
  Methods in molecular biology (Clifton, N.J.) 2012 Lakins JN, Chin AR, Weaver VM
• HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.
  The Journal of clinical investigation 2010 Gilbert PM, Mouw JK, Unger MA, Lakins JN, Gbegnon MK, Clemmer VB, Benezra M, Licht JD, Boudreau NJ, Tsai KK, Welm AL, Feldman MD, Weber BL, Weaver VM
• Matrix crosslinking forces tumor progression by enhancing integrin signaling.
  Cell 2009 Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser DL, Weaver VM
• alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini.
  Journal of cell science 2007 Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM
• Tensional homeostasis and the malignant phenotype.
  Cancer cell 2005 Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM
• Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors.
  The Journal of cell biology 2003 Zahir N, Lakins JN, Russell A, Ming W, Chatterjee C, Rozenberg GI, Marinkovich MP, Weaver VM
• Evidence that clusterin has discrete chaperone and ligand binding sites.
  Biochemistry 2002 Lakins JN, Poon S, Easterbrook-Smith SB, Carver JA, Tenniswood MP, Wilson MR