John Witte, PhD, MS
Professor
Epidemiology & Biostatistics
School of Medicine

I have developed widely used methods and software for studying rare genetic variants, pathways, interactions, and genome-wide association studies. I am applying these methods to studies of cancer, birth defects, and pharmacogenomics. Current projects in my lab include developing methods for effectively evaluating pleiotropy, determining the germline and somatic basis of prostate cancer risk and aggressiveness, and detecting genes that impact drug / treatment response. We have also recently been evaluating the use of cell free DNA (liquid biopsies) for prediction of prostate cancer risk and progression. In addition, I direct an NIH-Funded post-Doctoral training grant in Genetic Cancer Epidemiology, and have mentored over 40 pre- and post-doctoral fellows.

• A gene-based association test of interactions for maternal-fetal genotypes identifies genes associated with nonsyndromic congenital heart defects.
  Genetic epidemiology 2023 Huang M, Lyu C, Liu N, Nembhard WN, Witte JS, Hobbs CA, Li M, National Birth Defects Prevention Study
• Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry.
  American journal of human genetics 2023 Darst BF, Shen J, Madduri RK, Rodriguez AA, Xiao Y, Sheng X, Saunders EJ, Dadaev T, Brook MN, Hoffmann TJ, Muir K, Wan P, Le Marchand L, Wilkens L, Wang Y, Schleutker J, MacInnis RJ, Cybulski C, Neal …
• The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics.
  bioRxiv : the preprint server for biology 2023 Yee SW, Macdonald C, Mitrovic D, Zhou X, Koleske ML, Yang J, Silva DB, Grimes PR, Trinidad D, More SS, Kachuri L, Witte JS, Delemotte L, Giacomini KM, Coyote-Maestas W
• Genetically adjusted PSA levels for prostate cancer screening.
  Nature medicine 2023 Kachuri L, Hoffmann TJ, Jiang Y, Berndt SI, Shelley JP, Schaffer KR, Machiela MJ, Freedman ND, Huang WY, Li SA, Easterlin R, Goodman PJ, Till C, Thompson I, Lilja H, Van Den Eeden SK, Chanock SJ, …
• A complex systems model of breast cancer etiology: The Paradigm II Model.
  PloS one 2023 Hiatt RA, Worden L, Rehkopf D, Engmann N, Troester M, Witte JS, Balke K, Jackson C, Barlow J, Fenton SE, Gehlert S, Hammond RA, Kaplan G, Kornak J, Nishioka K, McKone T, Smith MT, Trasande L, Porco TC
• Development and testing of a polygenic risk score for breast cancer aggressiveness.
  NPJ precision oncology 2023 Shieh Y, Roger J, Yau C, Wolf DM, Hirst GL, Swigart LB, Huntsman S, Hu D, Nierenberg JL, Middha P, Heise RS, Shi Y, Kachuri L, Zhu Q, Yao S, Ambrosone CB, Kwan ML, Caan BJ, Witte JS, Kushi LH, 't Veer…
• Evaluating Approaches for Constructing Polygenic Risk Scores for Prostate Cancer in Men of African and European Ancestry.
  medRxiv : the preprint server for health sciences 2023 Darst BF, Shen J, Madduri RK, Rodriguez AA, Xiao Y, Sheng X, Saunders EJ, Dadaev T, Brook MN, Hoffmann TJ, Muir K, Wan P, Le Marchand L, Wilkens L, Wang Y, Schleutker J, MacInnis RJ, Cybulski C, Neal …
• Transcriptome-Wide Association Analysis Identifies Novel Candidate Susceptibility Genes for Prostate-Specific Antigen Levels in Men Without Prostate Cancer.
  medRxiv : the preprint server for health sciences 2023 Chen DM, Dong R, Kachuri L, Hoffmann T, Jiang Y, Berndt SI, Shelley JP, Schaffer KR, Machiela MJ, Freedman ND, Huang WY, Li SA, Lilja H, Van Den Eeden SK, Chanock S, Haiman CA, Conti DV, Klein RJ, …
• A Polygenic Risk Score for Prostate Cancer Risk Prediction.
  JAMA internal medicine 2023 Schaffer KR, Shi M, Shelley JP, Tosoian JJ, Kachuri L, Witte JS, Mosley JD
• Evidence of Novel Susceptibility Variants for Prostate Cancer and a Multiancestry Polygenic Risk Score Associated with Aggressive Disease in Men of African Ancestry.
  European urology 2023 Chen F, Madduri RK, Rodriguez AA, Darst BF, Chou A, Sheng X, Wang A, Shen J, Saunders EJ, Rhie SK, Bensen JT, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B, Isaacs WB, Stanford JL, Zheng W, …
• Re-envisioning community genetics: community empowerment in preventive genomics.
  Journal of community genetics 2023 Wand H, Martschenko DO, Smitherman A, Michelson S, Pun T, Witte JS, Scott SA, Cho MK, Ashley EA, Preventive Genomics Program Co-Design Working Group
• Use of Monitoring Tests Among Patients With Localized Prostate Cancer Managed With Observation.
  The Journal of urology 2023 Leapman MS, Wang R, Loeb S, Seibert TM, Gaylis FD, Lowentritt B, Brown GA, Chen R, Lin D, Witte J, Cooperberg MR, Catalona WJ, Gross CP, Ma X
• Assessment of genetic susceptibility to multiple primary cancers through whole-exome sequencing in two large multi-ancestry studies.
  BMC medicine 2022 Cavazos TB, Kachuri L, Graff RE, Nierenberg JL, Thai KK, Alexeeff S, Van Den Eeden S, Corley DA, Kushi LH, Regeneron Genetics Center, Hoffmann TJ, Ziv E, Habel LA, Jorgenson E, Sakoda LC, Witte JS
• Random field modeling of multi-trait multi-locus association for detecting methylation quantitative trait loci.
  Bioinformatics (Oxford, England) 2022 Lyu C, Huang M, Liu N, Chen Z, Lupo PJ, Tycko B, Witte JS, Hobbs CA, Li M
• Genetic Analysis of Lung Cancer and the Germline Impact on Somatic Mutation Burden.
  Journal of the National Cancer Institute 2022 Gabriel AAG, Atkins JR, Penha RCC, Smith-Byrne K, Gaborieau V, Voegele C, Abedi-Ardekani B, Milojevic M, Olaso R, Meyer V, Boland A, Deleuze JF, Zaridze D, Mukeriya A, Swiatkowska B, Janout V, …
• Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.
  Nature genetics 2022 Byun J, Han Y, Li Y, Xia J, Long E, Choi J, Xiao X, Zhu M, Zhou W, Sun R, Bossé Y, Song Z, Schwartz A, Lusk C, Rafnar T, Stefansson K, Zhang T, Zhao W, Pettit RW, Liu Y, Li X, Zhou H, Walsh KM, Gorlov…
• Cancer systems epidemiology: Overcoming misconceptions and integrating systems approaches into cancer research.
  PLoS medicine 2022 Mabry PL, Pronk NP, Amos CI, Witte JS, Wedlock PT, Bartsch SM, Lee BY
• The Role of Dementia Diagnostic Delay in the Inverse Cancer-Dementia Association.
  The journals of gerontology. Series A, Biological sciences and medical sciences 2022 Hayes-Larson E, Shaw C, Ackley SF, Zimmerman SC, Glymour MM, Graff RE, Witte JS, Kobayashi LC, Mayeda ER
• A genome-wide association study of obstructive heart defects among participants in the National Birth Defects Prevention Study.
  American journal of medical genetics. Part A 2022 Rashkin SR, Cleves M, Shaw GM, Nembhard WN, Nestoridi E, Jenkins MM, Romitti PA, Lou XY, Browne ML, Mitchell LE, Olshan AF, Lomangino K, Bhattacharyya S, Witte JS, Hobbs CA, National Birth Defects …
• Response to Comment on Dawed et al. Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas. Diabetes Care 2021;44:2673-2682.
  Diabetes care 2022 Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, …
• Epidemiology and economic burden of meningococcal disease in Germany: A systematic review.
  Vaccine 2022 Gruhn S, Witte J, Greiner W, Damm O, Dietzsch M, Kramer R, Knuf M
• Association Between a 22-feature Genomic Classifier and Biopsy Gleason Upgrade During Active Surveillance for Prostate Cancer.
  European urology open science 2022 Press BH, Jones T, Olawoyin O, Lokeshwar SD, Rahman SN, Khajir G, Lin DW, Cooperberg MR, Loeb S, Darst BF, Zheng Y, Chen RC, Witte JS, Seibert TM, Catalona WJ, Leapman MS, Sprenkle PC
• Correction: Inflammatory bowel disease induces inflammatory and preneoplastic changes in the prostate.
  Prostate cancer and prostatic diseases 2022 Desai AS, Sagar V, Lysy B, Weiner AB, Ko OS, Driscoll C, Rodriguez Y, Vatapalli R, Unno K, Han H, Cohen JE, Vo AX, Pham M, Shin M, Jain-Poster K, Ross J, Morency EG, Meyers TJ, Witte JS, Wu J, …
• Genetic Factors Associated with Prostate Cancer Conversion from Active Surveillance to Treatment.
  HGG advances 2021 Jiang Y, Meyers TJ, Emeka AA, Cooley LF, Cooper PR, Lancki N, Helenowski I, Kachuri L, Lin DW, Stanford JL, Newcomb LF, Kolb S, Finelli A, Fleshner NE, Komisarenko M, Eastham JA, Ehdaie B, Benfante N,…
• Residential particulate matter, proximity to major roads, traffic density and traffic volume as risk factors for preterm birth in California.
  Paediatric and perinatal epidemiology 2021 Costello JM, Steurer MA, Baer RJ, Witte JS, Jelliffe-Pawlowski LL
• Detecting methylation quantitative trait loci using a methylation random field method.
  Briefings in bioinformatics 2021 Lyu C, Huang M, Liu N, Chen Z, Lupo PJ, Tycko B, Witte JS, Hobbs CA, Li M
• Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas.
  Diabetes care 2021 Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, …
• Factors Associated with Time to Conversion from Active Surveillance to Treatment for Prostate Cancer in a Multi-Institutional Cohort.
  The Journal of urology 2021 Cooley LF, Emeka AA, Meyers TJ, Cooper PR, Lin DW, Finelli A, Eastham JA, Logothetis CJ, Marks LS, Vesprini D, Goldenberg SL, Higano CS, Pavlovich CP, Chan JM, Morgan TM, Klein EA, Barocas DA, Loeb S,…
• Reply by Authors.
  The Journal of urology 2021 Cooley LF, Emeka AA, Meyers TJ, Cooper PR, Lin DW, Finelli A, Eastham JA, Logothetis CJ, Marks LS, Vesprini D, Goldenberg SL, Higano CS, Pavlovich CP, Chan JM, Morgan TM, Klein EA, Barocas DA, Loeb S,…
• Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.
  American journal of human genetics 2021 Kachuri L, Jeon S, DeWan AT, Metayer C, Ma X, Witte JS, Chiang CWK, Wiemels JL, de Smith AJ
• The Association Between Cancer and Spousal Rate of Memory Decline: A Negative Control Study to Evaluate (Unmeasured) Social Confounding of the Cancer-memory Relationship.
  Alzheimer disease and associated disorders 2021 Ospina-Romero M, Brenowitz WD, Glymour MM, Mayeda ER, Graff RE, Witte JS, Ackley SF, Lu KP, Kobayashi LC
• Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease.
  BMC genomic data 2021 Li M, Lyu C, Huang M, Do C, Tycko B, Lupo PJ, MacLeod SL, Randolph CE, Liu N, Witte JS, Hobbs CA
• Inflammatory bowel disease induces inflammatory and pre-neoplastic changes in the prostate.
  Prostate cancer and prostatic diseases 2021 Desai AS, Sagar V, Lysy B, Weiner AB, Ko OS, Driscoll C, Rodriguez Y, Vatapalli R, Unno K, Han H, Cohen JE, Vo AX, Pham M, Shin M, Jain-Poster K, Ross J, Morency EG, Meyers TJ, Witte JS, Wu J, …
• Cell-Free DNA Detection of Tumor Mutations in Heterogeneous, Localized Prostate Cancer Via Targeted, Multiregion Sequencing.
  JCO precision oncology 2021 Chen E, Cario CL, Leong L, Lopez K, Márquez CP, Li PS, Oropeza E, Tenggara I, Cowan J, Simko JP, Kageyama R, Wells DK, Chan JM, Friedlander T, Aggarwal R, Paris PL, Feng F, Carroll PR, Witte JS
• A two-step approach to testing overall effect of gene-environment interaction for multiple phenotypes.
  Bioinformatics (Oxford, England) 2021 Majumdar A, Burch KS, Haldar T, Sankararaman S, Pasaniuc B, Gauderman WJ, Witte JS
• Defining Quality Metrics for Active Surveillance: The Michigan Urological Surgery Improvement Collaborative Experience. Letter.
  The Journal of urology 2021 Gaylis FD, Cooperberg MR, Chen RC, Malin J, Loeb S, Witte JS, Carroll PR, Cohen ES, Dato PE, Lin DW, Zheng Y, Seibert TM, Setzler C, Wilt W, Gomez SL, Chan JML, Catalona WJ
• Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry.
  American journal of human genetics 2021 Graff M, Justice AE, Young KL, Marouli E, Zhang X, Fine RS, Lim E, Buchanan V, Rand K, Feitosa MF, Wojczynski MK, Yanek LR, Shao Y, Rohde R, Adeyemo AA, Aldrich MC, Allison MA, Ambrosone CB, Ambs S, …
• Cell-free DNA concentration and fragment size as a biomarker for prostate cancer.
  Scientific reports 2021 Chen E, Cario CL, Leong L, Lopez K, Márquez CP, Chu C, Li PS, Oropeza E, Tenggara I, Cowan J, Simko JP, Chan JM, Friedlander T, Wyatt AW, Aggarwal R, Paris PL, Carroll PR, Feng F, Witte JS
• Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
  Nature genetics 2021 Conti DV, Darst BF, Moss LC, Saunders EJ, Sheng X, Chou A, Schumacher FR, Olama AAA, Benlloch S, Dadaev T, Brook MN, Sahimi A, Hoffmann TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Muir K, …
• Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts.
  Nature communications 2021 Graff RE, Cavazos TB, Thai KK, Kachuri L, Rashkin SR, Hoffman JD, Alexeeff SE, Blatchins M, Meyers TJ, Leong L, Tai CG, Emami NC, Corley DA, Kushi LH, Ziv E, Van Den Eeden SK, Jorgenson E, Hoffmann TJ…
• Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
  Nature genetics 2021 Conti DV, Darst BF, Moss LC, Saunders EJ, Sheng X, Chou A, Schumacher FR, Olama AAA, Benlloch S, Dadaev T, Brook MN, Sahimi A, Hoffmann TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Muir K, …
• A Large-Scale Association Study Detects Novel Rare Variants, Risk Genes, Functional Elements, and Polygenic Architecture of Prostate Cancer Susceptibility.
  Cancer research 2020 Emami NC, Cavazos TB, Rashkin SR, Cario CL, Graff RE, Tai CG, Mefford JA, Kachuri L, Wan E, Wong S, Aaronson D, Presti J, Habel LA, Shan J, Ranatunga DK, Chao CR, Ghai NR, Jorgenson E, Sakoda LC, …
• Inclusion of variants discovered from diverse populations improves polygenic risk score transferability.
  HGG advances 2020 Cavazos TB, Witte JS
• Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction.
  Nature communications 2020 Kachuri L, Graff RE, Smith-Byrne K, Meyers TJ, Rashkin SR, Ziv E, Witte JS, Johansson M
• Association Between Alzheimer Disease and Cancer With Evaluation of Study Biases: A Systematic Review and Meta-analysis.
  JAMA network open 2020 Ospina-Romero M, Glymour MM, Hayes-Larson E, Mayeda ER, Graff RE, Brenowitz WD, Ackley SF, Witte JS, Kobayashi LC
• The landscape of host genetic factors involved in immune response to common viral infections.
  Genome medicine 2020 Kachuri L, Francis SS, Morrison ML, Wendt GA, Bossé Y, Cavazos TB, Rashkin SR, Ziv E, Witte JS
• The landscape of host genetic factors involved in immune response to common viral infections.
  medRxiv : the preprint server for health sciences 2020 Kachuri L, Francis SS, Morrison M, Wendt GA, Bossé Y, Cavazos TB, Rashkin SR, Ziv E, Witte JS
• Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts.
  Nature communications 2020 Rashkin SR, Graff RE, Kachuri L, Thai KK, Alexeeff SE, Blatchins MA, Cavazos TB, Corley DA, Emami NC, Hoffman JD, Jorgenson E, Kushi LH, Meyers TJ, Van Den Eeden SK, Ziv E, Habel LA, Hoffmann TJ, …
• The competing risk of death and selective survival cannot fully explain the inverse cancer-dementia association.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2020 Hayes-Larson E, Ackley SF, Zimmerman SC, Ospina-Romero M, Glymour MM, Graff RE, Witte JS, Kobayashi LC, Mayeda ER
• A machine learning approach to optimizing cell-free DNA sequencing panels: with an application to prostate cancer.
  BMC cancer 2020 Cario CL, Chen E, Leong L, Emami NC, Lopez K, Tenggara I, Simko JP, Friedlander TW, Li PS, Paris PL, Carroll PR, Witte JS
• Congenital diaphragmatic hernia and maternal dietary nutrient pathways and diet quality.
  Birth defects research 2020 Carmichael SL, Ma C, Witte JS, Yang W, Rasmussen SA, Brunelli L, Nestoridi E, Shaw GM, Feldkamp ML, National Birth Defects Prevention Study
• Genomewide Meta-Analysis Validates a Role for S1PR1 in Microtubule Targeting Agent-Induced Sensory Peripheral Neuropathy.
  Clinical pharmacology and therapeutics 2020 Chua KC, Xiong C, Ho C, Mushiroda T, Jiang C, Mulkey F, Lai D, Schneider BP, Rashkin SR, Witte JS, Friedman PN, Ratain MJ, McLeod HL, Rugo HS, Shulman LN, Kubo M, Owzar K, Kroetz DL
• Age-of-onset information helps identify 76 genetic variants associated with allergic disease.
  PLoS genetics 2020 Ferreira MAR, Vonk JM, Baurecht H, Marenholz I, Tian C, Hoffman JD, Helmer Q, Tillander A, Ullemar V, Lu Y, Grosche S, Rüschendorf F, Granell R, Brumpton BM, Fritsche LG, Bhatta L, Gabrielsen ME, …
• Association between inflammatory bowel disease and prostate cancer: A large-scale, prospective, population-based study.
  International journal of cancer 2020 Meyers TJ, Weiner AB, Graff RE, Desai AS, Cooley LF, Catalona WJ, Hanauer SB, Wu JD, Schaeffer EM, Abdulkadir SA, Kundu SD, Witte JS
• Efficient Estimation and Applications of Cross-Validated Genetic Predictions to Polygenic Risk Scores and Linear Mixed Models.
  Journal of computational biology : a journal of computational molecular cell biology 2020 Mefford J, Park D, Zheng Z, Ko A, Ala-Korpela M, Laakso M, Pajukanta P, Yang J, Witte J, Zaitlen N
• A meta-analysis of genome-wide association studies of multiple myeloma among men and women of African ancestry.
  Blood advances 2020 Du Z, Weinhold N, Song GC, Rand KA, Van Den Berg DJ, Hwang AE, Sheng X, Hom V, Ailawadhi S, Nooka AK, Singhal S, Pawlish K, Peters ES, Bock C, Mohrbacher A, Stram A, Berndt SI, Blot WJ, Casey G, …
• Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility.
  Nature communications 2020 Kachuri L, Johansson M, Rashkin SR, Graff RE, Bossé Y, Manem V, Caporaso NE, Landi MT, Christiani DC, Vineis P, Liu G, Scelo G, Zaridze D, Shete SS, Albanes D, Aldrich MC, Tardón A, Rennert G, Chen C,…
• Development and pilot evaluation of a personalized decision support intervention for low risk prostate cancer patients.
  Cancer medicine 2019 Belkora J, Chan JM, Cooperberg MR, Neuhaus J, Stupar L, Weinberg T, Broering JM, Tenggara I, Cowan JE, Rosenfeld S, Kenfield SA, Van Blarigan EL, Simko JP, Witte J, Carroll PR
• Germline testing in those at risk of prostate cancer.
  The Canadian journal of urology 2019 Carroll PR, Witte JS, Parsons JK
• Author Correction: Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms.
  Nature communications 2019 Emami NC, Kachuri L, Meyers TJ, Das R, Hoffman JD, Hoffmann TJ, Hu D, Shan J, Feng FY, Ziv E, Van Den Eeden SK, Witte JS
• Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms.
  Nature communications 2019 Emami NC, Kachuri L, Meyers TJ, Das R, Hoffman JD, Hoffmann TJ, Hu D, Shan J, Feng FY, Ziv E, Van Den Eeden SK, Witte JS
• A genome-wide association study of prostate cancer in Latinos.
  International journal of cancer 2019 Du Z, Hopp H, Ingles SA, Huff C, Sheng X, Weaver B, Stern M, Hoffmann TJ, John EM, Van Den Eeden SK, Strom S, Leach RJ, Thompson IM, Witte JS, Conti DV, Haiman CA
• Methods for measuring financial toxicity after cancer diagnosis and treatment: a systematic review and its implications.
  Annals of oncology : official journal of the European Society for Medical Oncology 2019 Witte J, Mehlis K, Surmann B, Lingnau R, Damm O, Greiner W, Winkler EC
• Identification of Novel Susceptibility Loci and Genes for Prostate Cancer Risk: A Transcriptome-Wide Association Study in Over 140,000 European Descendants.
  Cancer research 2019 Wu L, Wang J, Cai Q, Cavazos TB, Emami NC, Long J, Shu XO, Lu Y, Guo X, Bauer JA, Pasaniuc B, Penney KL, Freedman ML, Kote-Jarai Z, Witte JS, Haiman CA, Eeles RA, Zheng W, PRACTICAL, CRUK, BPC3, CAPS,…
• Samasy: an automated system for sample selection and robotic transfer.
  BioTechniques 2018 Cario CL, Witte JS
• A Pharmacogenetic Prediction Model of Progression-Free Survival in Breast Cancer using Genome-Wide Genotyping Data from CALGB 40502 (Alliance).
  Clinical pharmacology and therapeutics 2018 Rashkin SR, Chua KC, Ho C, Mulkey F, Jiang C, Mushiroda T, Kubo M, Friedman PN, Rugo HS, McLeod HL, Ratain MJ, Castillos F, Naughton M, Overmoyer B, Toppmeyer D, Witte JS, Owzar K, Kroetz DL
• Newborn Metabolic Profile Associated with Hyperbilirubinemia With and Without Kernicterus.
  Clinical and translational science 2018 McCarthy ME, Oltman SP, Baer RJ, Ryckman KK, Rogers EE, Steurer-Muller MA, Witte JS, Jelliffe-Pawlowski LL
• Personalized Prostate Cancer Screening Based on a Single Midlife Prostate-specific Antigen Measurement.
  European urology 2018 Graff RE, Kachuri L, Witte JS
• Detecting Rare Mutations with Heterogeneous Effects Using a Family-Based Genetic Random Field Method.
  Genetics 2018 Li M, He Z, Tong X, Witte JS, Lu Q
• Two HLA Class II Gene Variants Are Independently Associated with Pediatric Osteosarcoma Risk.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2018 Zhang C, Wiemels JL, Hansen HM, Gonzalez-Maya J, Endicott AA, de Smith AJ, Smirnov IV, Witte JS, Morimoto LM, Metayer C, Walsh KM
• Quantitative Spatial Profiling of PD-1/PD-L1 Interaction and HLA-DR/IDO-1 Predicts Improved Outcomes of Anti-PD-1 Therapies in Metastatic Melanoma.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Johnson DB, Bordeaux J, Kim JY, Vaupel C, Rimm DL, Ho TH, Joseph RW, Daud AI, Conry RM, Gaughan EM, Hernandez-Aya LF, Dimou A, Funchain P, Smithy J, Witte JS, McKee SB, Ko J, Wrangle JM, Dabbas B, …
• Orchid: a novel management, annotation and machine learning framework for analyzing cancer mutations.
  Bioinformatics (Oxford, England) 2018 Cario CL, Witte JS
• An efficient Bayesian meta-analysis approach for studying cross-phenotype genetic associations.
  PLoS genetics 2018 Majumdar A, Haldar T, Bhattacharya S, Witte JS
• A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma.
  The Journal of allergy and clinical immunology 2018 Asai Y, Eslami A, van Ginkel CD, Akhabir L, Wan M, Yin D, Ellis G, Ben-Shoshan M, Marenholz I, Martino D, Ferreira MA, Allen K, Mazer B, de Groot H, de Jong NW, Gerth van Wijk R, Dubois AEJ, Grosche S…
• Identification of Pleiotropic Cancer Susceptibility Variants from Genome-Wide Association Studies Reveals Functional Characteristics.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2017 Wu YH, Graff RE, Passarelli MN, Hoffman JD, Ziv E, Hoffmann TJ, Witte JS
• Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
  Nature genetics 2017 Ferreira MA, Vonk JM, Baurecht H, Marenholz I, Tian C, Hoffman JD, Helmer Q, Tillander A, Ullemar V, van Dongen J, Lu Y, Rüschendorf F, Esparza-Gordillo J, Medway CW, Mountjoy E, Burrows K, Hummel O, …
• Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy.
  The Journal of allergy and clinical immunology 2017 Asai Y, Eslami A, van Ginkel CD, Akhabir L, Wan M, Ellis G, Ben-Shoshan M, Martino D, Ferreira MA, Allen K, Mazer B, de Groot H, de Jong NW, Gerth van Wijk RN, Dubois AEJ, Chin R, Cheuk S, Hoffman J, …
• Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases.
  American journal of epidemiology 2017 McAllister K, Mechanic LE, Amos C, Aschard H, Blair IA, Chatterjee N, Conti D, Gauderman WJ, Hsu L, Hutter CM, Jankowska MM, Kerr J, Kraft P, Montgomery SB, Mukherjee B, Papanicolaou GJ, Patel CJ, …
• Update on the State of the Science for Analytical Methods for Gene-Environment Interactions.
  American journal of epidemiology 2017 Gauderman WJ, Mukherjee B, Aschard H, Hsu L, Lewinger JP, Patel CJ, Witte JS, Amos C, Tai CG, Conti D, Torgerson DG, Lee S, Chatterjee N
• Up For A Challenge (U4C): Stimulating innovation in breast cancer genetic epidemiology.
  PLoS genetics 2017 Mechanic LE, Lindström S, Daily KM, Sieberts SK, Amos CI, Chen HS, Cox NJ, Dathe M, Feuer EJ, Guertin MJ, Hoffman J, Liu Y, Moore JH, Myers CL, Ritchie MD, Schildkraut J, Schumacher F, Witte JS, Wang …
• Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry.
  Journal of the National Cancer Institute 2017 Conti DV, Wang K, Sheng X, Bensen JT, Hazelett DJ, Cook MB, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B, Isaacs WB, Stanford JL, Zheng W, Sanderson M, John EM, Park JY, Xu J, Stevens VL, …
• Non-additive and epistatic effects of HLA polymorphisms contributing to risk of adult glioma.
  Journal of neuro-oncology 2017 Zhang C, de Smith AJ, Smirnov IV, Wiencke JK, Wiemels JL, Witte JS, Walsh KM
• Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium.
  PLoS genetics 2017 Ng MCY, Graff M, Lu Y, Justice AE, Mudgal P, Liu CT, Young K, Yanek LR, Feitosa MF, Wojczynski MK, Rand K, Brody JA, Cade BE, Dimitrov L, Duan Q, Guo X, Lange LA, Nalls MA, Okut H, Tajuddin SM, Tayo …
• Investigating the Genetic Architecture of the PR Interval Using Clinical Phenotypes.
  Circulation. Cardiovascular genetics 2017 Mosley JD, Shoemaker MB, Wells QS, Darbar D, Shaffer CM, Edwards TL, Bastarache L, McCarty CA, Thompson W, Chute CG, Jarvik GP, Crosslin DR, Larson EB, Kullo IJ, Pacheco JA, Peissig PL, Brilliant MH, …
• Cis-eQTL-based trans-ethnic meta-analysis reveals novel genes associated with breast cancer risk.
  PLoS genetics 2017 Hoffman JD, Graff RE, Emami NC, Tai CG, Passarelli MN, Hu D, Huntsman S, Hadley D, Leong L, Majumdar A, Zaitlen N, Ziv E, Witte JS
• Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.
  Nature communications 2017 Hoffmann TJ, Passarelli MN, Graff RE, Emami NC, Sakoda LC, Jorgenson E, Habel LA, Shan J, Ranatunga DK, Quesenberry CP, Chao CR, Ghai NR, Aaronson D, Presti J, Nordström T, Wang Z, Berndt SI, Chanock …
• Familial Risk and Heritability of Colorectal Cancer in the Nordic Twin Study of Cancer.
  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2017 Graff RE, Möller S, Passarelli MN, Witte JS, Skytthe A, Christensen K, Tan Q, Adami HO, Czene K, Harris JR, Pukkala E, Kaprio J, Giovannucci EL, Mucci LA, Hjelmborg JB
• Tissue Sources for Accurate Measurement of Germline DNA Genotypes in Prostate Cancer Patients Treated With Radical Prostatectomy.
  The Prostate 2016 Emami NC, Leong L, Wan E, Van Blarigan EL, Cooperberg MR, Tenggara I, Carroll PR, Chan JM, Witte JS, Simko JP
• Sequence variation in folate pathway genes and risks of human cleft lip with or without cleft palate.
  American journal of medical genetics. Part A 2016 Marini NJ, Yang W, Asrani K, Witte JS, Rine J, Lammer EJ, Shaw GM
• Telomere structure and maintenance gene variants and risk of five cancer types.
  International journal of cancer 2016 Karami S, Han Y, Pande M, Cheng I, Rudd J, Pierce BL, Nutter EL, Schumacher FR, Kote-Jarai Z, Lindstrom S, Witte JS, Fang S, Han J, Kraft P, Hunter DJ, Song F, Hung RJ, McKay J, Gruber SB, Chanock SJ,…
• A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2016 Rand KA, Song C, Dean E, Serie DJ, Curtin K, Sheng X, Hu D, Huff CA, Bernal-Mizrachi L, Tomasson MH, Ailawadhi S, Singhal S, Pawlish K, Peters ES, Bock CH, Stram A, Van Den Berg DJ, Edlund CK, Conti …
• Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.
  Nature genetics 2016 Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M…
• Erratum to: Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls.
  Human genetics 2016 Brenner DR, Brennan P, Boffetta P, Amos CI, Spitz MR, Chen C, Goodman G, Heinrich J, Bickeböller H, Rosenberger A, Risch A, Muley T, McLaughlin JR, Benhamou S, Bouchardy C, Lewinger JP, Witte JS, Chen…
• Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans.
  AIDS (London, England) 2016 Lee SA, Mefford JA, Huang Y, Witte JS, Martin JN, Haas DW, Mclaren PJ, Mushiroda T, Kubo M, Byakwaga H, Hunt PW, Kroetz DL
• Determining Which Phenotypes Underlie a Pleiotropic Signal.
  Genetic epidemiology 2016 Majumdar A, Haldar T, Witte JS
• Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome.
  Critical care (London, England) 2016 Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA, NHLBI ARDS Network
• Selection and explosive growth alter genetic architecture and hamper the detection of causal rare variants.
  Genome research 2016 Uricchio LH, Zaitlen NA, Ye CJ, Witte JS, Hernandez RD
• Identifying genetically driven clinical phenotypes using linear mixed models.
  Nature communications 2016 Mosley JD, Witte JS, Larkin EK, Bastarache L, Shaffer CM, Karnes JH, Stein CM, Phillips E, Hebbring SJ, Brilliant MH, Mayer J, Ye Z, Roden DM, Denny JC
• Joint effects of genetic variants and residential proximity to pesticide applications on hypospadias risk.
  Birth defects research. Part A, Clinical and molecular teratology 2016 Carmichael SL, Yang W, Ma C, Roberts E, Kegley S, English P, Lammer EJ, Witte JS, Shaw GM
• Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.
  Nature communications 2016 Gusev A, Shi H, Kichaev G, Pomerantz M, Li F, Long HW, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B, Isaacs WB, Zheng W, Pettaway CA, Yeboah ED, Tettey Y, Biritwum RB, Adjei AA, Tay E, …
• Testing Allele Transmission of an SNP Set Using a Family-Based Generalized Genetic Random Field Method.
  Genetic epidemiology 2016 Li M, Li J, He Z, Lu Q, Witte JS, Macleod SL, Hobbs CA, Cleves MA, National Birth Defects Prevention Study
• Mutational Landscape of Aggressive Prostate Tumors in African American Men.
  Cancer research 2016 Lindquist KJ, Paris PL, Hoffmann TJ, Cardin NJ, Kazma R, Mefford JA, Simko JP, Ngo V, Chen Y, Levin AM, Chitale D, Helfand BT, Catalona WJ, Rybicki BA, Witte JS
• Prostate Cancer Susceptibility in Men of African Ancestry at 8q24.
  Journal of the National Cancer Institute 2016 Han Y, Rand KA, Hazelett DJ, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B, Isaacs WB, Stanford JL, Zheng W, Schumacher FR, Berndt SI, Wang Z, Xu J, Rohland N, Reich D, Tandon A, Pasaniuc B,…
• A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2015 Scarbrough PM, Weber RP, Iversen ES, Brhane Y, Amos CI, Kraft P, Hung RJ, Sellers TA, Witte JS, Pharoah P, Henderson BE, Gruber SB, Hunter DJ, Garber JE, Joshi AD, McDonnell K, Easton DF, Eeles R, …
• Semiparametric Allelic Tests for Mapping Multiple Phenotypes: Binomial Regression and Mahalanobis Distance.
  Genetic epidemiology 2015 Majumdar A, Witte JS, Ghosh S
• MDS-associated somatic mutations and clonal hematopoiesis are common in idiopathic cytopenias of undetermined significance.
  Blood 2015 Kwok B, Hall JM, Witte JS, Xu Y, Reddy P, Lin K, Flamholz R, Dabbas B, Yung A, Al-Hafidh J, Balmert E, Vaupel C, El Hader C, McGinniss MJ, Nahas SA, Kines J, Bejar R
• Strategies for Imputing and Analyzing Rare Variants in Association Studies.
  Trends in genetics : TIG 2015 Hoffmann TJ, Witte JS
• Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer.
  Journal of the National Cancer Institute 2015 Hung RJ, Ulrich CM, Goode EL, Brhane Y, Muir K, Chan AT, Marchand LL, Schildkraut J, Witte JS, Eeles R, Boffetta P, Spitz MR, Poirier JG, Rider DN, Fridley BL, Chen Z, Haiman C, Schumacher F, Easton …
• Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions.
  Human molecular genetics 2015 Han Y, Hazelett DJ, Wiklund F, Schumacher FR, Stram DO, Berndt SI, Wang Z, Rand KA, Hoover RN, Machiela MJ, Yeager M, Burdette L, Chung CC, Hutchinson A, Yu K, Xu J, Travis RC, Key TJ, Siddiq A, …
• Methodological Considerations in Estimation of Phenotype Heritability Using Genome-Wide SNP Data, Illustrated by an Analysis of the Heritability of Height in a Large Sample of African Ancestry Adults.
  PloS one 2015 Chen F, He J, Zhang J, Chen GK, Thomas V, Ambrosone CB, Bandera EV, Berndt SI, Bernstein L, Blot WJ, Cai Q, Carpten J, Casey G, Chanock SJ, Cheng I, Chu L, Deming SL, Driver WR, Goodman P, Hayes RB, …
• A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.
  Cancer discovery 2015 Hoffmann TJ, Van Den Eeden SK, Sakoda LC, Jorgenson E, Habel LA, Graff RE, Passarelli MN, Cario CL, Emami NC, Chao CR, Ghai NR, Shan J, Ranatunga DK, Quesenberry CP, Aaronson D, Presti J, Wang Z, …
• Developments in our understanding of the genetic basis of birth defects.
  Birth defects research. Part A, Clinical and molecular teratology 2015 Webber DM, MacLeod SL, Bamshad MJ, Shaw GM, Finnell RH, Shete SS, Witte JS, Erickson SW, Murphy LD, Hobbs C
• Detecting gene-environment interactions in human birth defects: Study designs and statistical methods.
  Birth defects research. Part A, Clinical and molecular teratology 2015 Tai CG, Graff RE, Liu J, Passarelli MN, Mefford JA, Shaw GM, Hoffmann TJ, Witte JS
• Replication and heritability of prostate cancer risk variants: impact of population-specific factors.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2015 Virlogeux V, Graff RE, Hoffmann TJ, Witte JS
• Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases.
  Human genetics 2015 Helfand BT, Roehl KA, Cooper PR, McGuire BB, Fitzgerald LM, Cancel-Tassin G, Cornu JN, Bauer S, Van Blarigan EL, Chen X, Duggan D, Ostrander EA, Gwo-Shu M, Zhang ZF, Chang SC, Jeong S, Fontham ET, …
• Imputation of the rare HOXB13 G84E mutation and cancer risk in a large population-based cohort.
  PLoS genetics 2015 Hoffmann TJ, Sakoda LC, Shen L, Jorgenson E, Habel LA, Liu J, Kvale MN, Asgari MM, Banda Y, Corley D, Kushi LH, Quesenberry CP, Schaefer C, Van Den Eeden SK, Risch N, Witte JS
• Genetic polymorphisms in ESR1 and ESR2 genes, and risk of hypospadias in a multiethnic study population.
  The Journal of urology 2014 Choudhry S, Baskin LS, Lammer EJ, Witte JS, Dasgupta S, Ma C, Surampalli A, Shen J, Shaw GM, Carmichael SL
• Population genetic simulations of complex phenotypes with implications for rare variant association tests.
  Genetic epidemiology 2014 Uricchio LH, Torres R, Witte JS, Hernandez RD
• Leveraging population admixture to characterize the heritability of complex traits.
  Nature genetics 2014 Zaitlen N, Pasaniuc B, Sankararaman S, Bhatia G, Zhang J, Gusev A, Young T, Tandon A, Pollack S, Vilhjálmsson BJ, Assimes TL, Berndt SI, Blot WJ, Chanock S, Franceschini N, Goodman PG, He J, Hennis AJ…
• Genetic simulation tools for post-genome wide association studies of complex diseases.
  Genetic epidemiology 2014 Chen HS, Hutter CM, Mechanic LE, Amos CI, Bafna V, Hauser ER, Hernandez RD, Li C, Liberles DA, McAllister K, Moore JH, Paltoo DN, Papanicolaou GJ, Peng B, Ritchie MD, Rosenfeld G, Witte JS, Gillanders…
• Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: a systematic review and meta-analysis.
  PloS one 2014 Weng PH, Huang YL, Page JH, Chen JH, Xu J, Koutros S, Berndt S, Chanock S, Yeager M, Witte JS, Eeles RA, Easton DF, Neal DE, Donovan J, Hamdy FC, Muir KR, Giles G, Severi G, Smith JR, Balistreri CR, …
• Selenoprotein and antioxidant genes and the risk of high-grade prostate cancer and prostate cancer recurrence.
  The Prostate 2014 Gerstenberger JP, Bauer SR, Van Blarigan EL, Sosa E, Song X, Witte JS, Carroll PR, Chan JM
• Genome-wide scan of 29,141 African Americans finds no evidence of directional selection since admixture.
  American journal of human genetics 2014 Bhatia G, Tandon A, Patterson N, Aldrich MC, Ambrosone CB, Amos C, Bandera EV, Berndt SI, Bernstein L, Blot WJ, Bock CH, Caporaso N, Casey G, Deming SL, Diver WR, Gapstur SM, Gillanders EM, Harris CC,…
• The contribution of genetic variants to disease depends on the ruler.
  Nature reviews. Genetics 2014 Witte JS, Visscher PM, Wray NR
• A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
  Nature genetics 2014 Al Olama AA, Kote-Jarai Z, Berndt SI, Conti DV, Schumacher F, Han Y, Benlloch S, Hazelett DJ, Wang Z, Saunders E, Leongamornlert D, Lindstrom S, Jugurnauth-Little S, Dadaev T, Tymrakiewicz M, Stram DO…
• Generalizability of established prostate cancer risk variants in men of African ancestry.
  International journal of cancer 2014 Han Y, Signorello LB, Strom SS, Kittles RA, Rybicki BA, Stanford JL, Goodman PJ, Berndt SI, Carpten J, Casey G, Chu L, Conti DV, Rand KA, Diver WR, Hennis AJ, John EM, Kibel AS, Klein EA, Kolb S, Le …
• Radiogenomics: radiobiology enters the era of big data and team science.
  International journal of radiation oncology, biology, physics 2014 Rosenstein BS, West CM, Bentzen SM, Alsner J, Andreassen CN, Azria D, Barnett GC, Baumann M, Burnet N, Chang-Claude J, Chuang EY, Coles CE, Dekker A, De Ruyck K, De Ruysscher D, Drumea K, Dunning AM, …
• Copy number variation in bronchopulmonary dysplasia.
  American journal of medical genetics. Part A 2014 Hoffmann TJ, Shaw GM, Stevenson DK, Wang H, Quaintance CC, Oehlert J, Jelliffe-Pawlowski LL, Gould JB, Witte JS, O'Brodovich HM
• Performance of the Genomic Evaluators of Metastatic Prostate Cancer (GEMCaP) tumor biomarker for identifying recurrent disease in African American patients.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2014 Levin AM, Lindquist KJ, Avila A, Witte JS, Paris PL, Rybicki BA
• Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.
  Clinical pharmacology and therapeutics 2014 Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM
• Plasma antioxidants, genetic variation in SOD2, CAT, GPX1, GPX4, and prostate cancer survival.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2014 Van Blarigan EL, Ma J, Kenfield SA, Stampfer MJ, Sesso HD, Giovannucci EL, Witte JS, Erdman JW, Chan JM, Penney KL
• Genetic epidemiology and nonsyndromic structural birth defects: from candidate genes to epigenetics.
  JAMA pediatrics 2014 Hobbs CA, Chowdhury S, Cleves MA, Erickson S, MacLeod SL, Shaw GM, Shete S, Witte JS, Tycko B
• Maternal smoking, xenobiotic metabolizing enzyme gene variants, and gastroschisis risk.
  American journal of medical genetics. Part A 2014 Jenkins MM, Reefhuis J, Gallagher ML, Mulle JG, Hoffmann TJ, Koontz DA, Sturchio C, Rasmussen SA, Witte JS, Richter P, Honein MA, National Birth Defects Prevention Study
• Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).
  The pharmacogenomics journal 2014 Chhibber A, Mefford J, Stahl EA, Pendergrass SA, Baldwin RM, Owzar K, Li M, Winer EP, Hudis CA, Zembutsu H, Kubo M, Nakamura Y, McLeod HL, Ratain MJ, Shulman LN, Ritchie MD, Plenge RM, Witte JS, …
• Encapsulation status of papillary thyroid microcarcinomas is associated with the risk of lymph node metastases and tumor multifocality.
  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2013 Cupisti K, Lehwald N, Anlauf M, Riemer J, Werner TA, Krieg A, Witte J, Chanab A, Baldus SE, Krausch M, Raffel A, Herdter C, Schott M, Knoefel WT
• Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS data.
  PloS one 2013 Mosley JD, Van Driest SL, Larkin EK, Weeke PE, Witte JS, Wells QS, Karnes JH, Guo Y, Bastarache L, Olson LM, McCarty CA, Pacheco JA, Jarvik GP, Carrell DS, Larson EB, Crosslin DR, Kullo IJ, Tromp G, …
• Hypospadias and variants in genes related to sex hormone biosynthesis and metabolism.
  Andrology 2013 Carmichael SL, Witte JS, Ma C, Lammer EJ, Shaw GM
• Antioxidant and vitamin E transport genes and risk of high-grade prostate cancer and prostate cancer recurrence.
  The Prostate 2013 Bauer SR, Richman EL, Sosa E, Weinberg V, Song X, Witte JS, Carroll PR, Chan JM
• Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
  Nature genetics 2013 Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F,…
• A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
  Pediatrics 2013 Wang H, St Julien KR, Stevenson DK, Hoffmann TJ, Witte JS, Lazzeroni LC, Krasnow MA, Quaintance CC, Oehlert JW, Jelliffe-Pawlowski LL, Gould JB, Shaw GM, O'Brodovich HM
• Association of CYP2C9*2 with bosentan-induced liver injury.
  Clinical pharmacology and therapeutics 2013 Markova SM, De Marco T, Bendjilali N, Kobashigawa EA, Mefford J, Sodhi J, Le H, Zhang C, Halladay J, Rettie AE, Khojasteh C, McGlothlin D, Wu AH, Hsueh WC, Witte JS, Schwartz JB, Kroetz DL
• Hypospadias and genes related to genital tubercle and early urethral development.
  The Journal of urology 2013 Carmichael SL, Ma C, Choudhry S, Lammer EJ, Witte JS, Shaw GM
• Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia.
  Journal of human genetics 2013 Yee SW, Mefford JA, Singh N, Percival ME, Stecula A, Yang K, Witte JS, Takahashi A, Kubo M, Matsuda K, Giacomini KM, Andreadis C
• Influence of hyperoxia and physical exercise on *OH-radical stress in humans as measured by dihydroxylated benzoates (DHB) in urine.
  Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc 2013 Kähler W, Koch I, Wohlrab C, Kowalski J, Witte J, Koch A
• A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
  Nature genetics 2013 Monda KL, Chen GK, Taylor KC, Palmer C, Edwards TL, Lange LA, Ng MC, Adeyemo AA, Allison MA, Bielak LF, Chen G, Graff M, Irvin MR, Rhie SK, Li G, Liu Y, Liu Y, Lu Y, Nalls MA, Sun YV, Wojczynski MK, …
• Does accounting for gene-environment interactions help uncover association between rare variants and complex diseases?
  Human heredity 2013 Kazma R, Cardin NJ, Witte JS
• Turning of COGS moves forward findings for hormonally mediated cancers.
  Nature genetics 2013 Sakoda LC, Jorgenson E, Witte JS
• The impact of improved microarray coverage and larger sample sizes on future genome-wide association studies.
  Genetic epidemiology 2013 Lindquist KJ, Jorgenson E, Hoffmann TJ, Witte JS
• Global patterns of prostate cancer incidence, aggressiveness, and mortality in men of african descent.
  Prostate cancer 2013 Rebbeck TR, Devesa SS, Chang BL, Bunker CH, Cheng I, Cooney K, Eeles R, Fernandez P, Giri VN, Gueye SM, Haiman CA, Henderson BE, Heyns CF, Hu JJ, Ingles SA, Isaacs W, Jalloh M, John EM, Kibel AS, Kidd…
• HOXB13 mutation and prostate cancer: studies of siblings and aggressive disease.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2013 Witte JS, Mefford J, Plummer SJ, Liu J, Cheng I, Klein EA, Rybicki BA, Casey G
• Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls.
  Human genetics 2013 Brenner DR, Brennan P, Boffetta P, Amos CI, Spitz MR, Chen C, Goodman G, Heinrich J, Bickeböller H, Rosenberger A, Risch A, Muley T, McLaughlin JR, Benhamou S, Bouchardy C, Lewinger JP, Witte JS, Chen…
• Association of the innate immunity and inflammation pathway with advanced prostate cancer risk.
  PloS one 2012 Kazma R, Mefford JA, Cheng I, Plummer SJ, Levin AM, Rybicki BA, Casey G, Witte JS
• Diacylglycerol kinase K variants impact hypospadias in a California study population.
  The Journal of urology 2012 Carmichael SL, Mohammed N, Ma C, Iovannisci D, Choudhry S, Baskin LS, Witte JS, Shaw GM, Lammer EJ
• The Covariate's Dilemma.
  PLoS genetics 2012 Mefford J, Witte JS
• Reclassify controls at your own risk.
  Epidemiology (Cambridge, Mass.) 2012 Witte JS, Visscher PM
• A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Baldwin RM, Owzar K, Zembutsu H, Chhibber A, Kubo M, Jiang C, Watson D, Eclov RJ, Mefford J, McLeod HL, Friedman PN, Hudis CA, Winer EP, Jorgenson EM, Witte JS, Shulman LN, Nakamura Y, Ratain MJ, …
• Joint association testing of common and rare genetic variants using hierarchical modeling.
  Genetic epidemiology 2012 Cardin NJ, Mefford JA, Witte JS
• The future of clinical trials: A panel discussion.
  Statistics in medicine 2012 D'Agostino R, DeMets D, Friedewald W, Goodman S, Witte J, Geller NL
• Rare genetic variants and treatment response: sample size and analysis issues.
  Statistics in medicine 2012 Witte JS
• Genome-wide meta-analyses of smoking behaviors in African Americans.
  Translational psychiatry 2012 David SP, Hamidovic A, Chen GK, Bergen AW, Wessel J, Kasberger JL, Brown WM, Petruzella S, Thacker EL, Kim Y, Nalls MA, Tranah GJ, Sung YJ, Ambrosone CB, Arnett D, Bandera EV, Becker DM, Becker L, …
• The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury.
  Chest 2011 Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA, National Heart, Lung, and Blood Institute ARDS Network
• Next generation analytic tools for large scale genetic epidemiology studies of complex diseases.
  Genetic epidemiology 2011 Mechanic LE, Chen HS, Amos CI, Chatterjee N, Cox NJ, Divi RL, Fan R, Harris EL, Jacobs K, Kraft P, Leal SM, McAllister K, Moore JH, Paltoo DN, Province MA, Ramos EM, Ritchie MD, Roeder K, Schaid DJ, …
• A genetic signature of spina bifida risk from pathway-informed comprehensive gene-variant analysis.
  PloS one 2011 Marini NJ, Hoffmann TJ, Lammer EJ, Hardin J, Lazaruk K, Stein JB, Gilbert DA, Wright C, Lipzen A, Pennacchio LA, Carmichael SL, Witte JS, Shaw GM, Rine J
• Use of principal components to aggregate rare variants in case-control and family-based association studies in the presence of multiple covariates.
  BMC proceedings 2011 Kazma R, Hoffmann TJ, Witte JS
• Impact of meat consumption, preparation, and mutagens on aggressive prostate cancer.
  PloS one 2011 Punnen S, Hardin J, Cheng I, Klein EA, Witte JS
• Variations in the heme oxygenase-1 microsatellite polymorphism are associated with plasma CD14 and viral load in HIV-infected African-Americans.
  Genes and immunity 2011 Seu L, Burt TD, Witte JS, Martin JN, Deeks SG, McCune JM
• Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
  PLoS genetics 2011 N'Diaye A, Chen GK, Palmer CD, Ge B, Tayo B, Mathias RA, Ding J, Nalls MA, Adeyemo A, Adoue V, Ambrosone CB, Atwood L, Bandera EV, Becker LC, Berndt SI, Bernstein L, Blot WJ, Boerwinkle E, Britton A, …
• Copy number alterations in prostate tumors and disease aggressiveness.
  Genes, chromosomes & cancer 2011 Cheng I, Levin AM, Tai YC, Plummer S, Chen GK, Neslund-Dudas C, Casey G, Rybicki BA, Witte JS
• A common 5'-UTR variant in MATE2-K is associated with poor response to metformin.
  Clinical pharmacology and therapeutics 2011 Choi JH, Yee SW, Ramirez AH, Morrissey KM, Jang GH, Joski PJ, Mefford JA, Hesselson SE, Schlessinger A, Jenkins G, Castro RA, Johns SJ, Stryke D, Sali A, Ferrin TE, Witte JS, Kwok PY, Roden DM, Wilke …
• Evaluation of polymorphisms in EWSR1 and risk of Ewing sarcoma: a report from the Childhood Cancer Survivor Study.
  Pediatric blood & cancer 2011 DuBois SG, Goldsby R, Segal M, Woo J, Copren K, Kane JP, Pullinger CR, Matthay KK, Witte J, Lessnick SL, Robison LL, Bhatia S, Strong LC
• Impact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer risk.
  Nutrition and cancer 2011 Hardin J, Cheng I, Witte JS
• The landscape of recombination in African Americans.
  Nature 2011 Hinch AG, Tandon A, Patterson N, Song Y, Rohland N, Palmer CD, Chen GK, Wang K, Buxbaum SG, Akylbekova EL, Aldrich MC, Ambrosone CB, Amos C, Bandera EV, Berndt SI, Bernstein L, Blot WJ, Bock CH, …
• Of models and methods.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2011 Witte JS
• Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans.
  PLoS genetics 2011 Haiman CA, Chen GK, Blot WJ, Strom SS, Berndt SI, Kittles RA, Rybicki BA, Isaacs WB, Ingles SA, Stanford JL, Diver WR, Witte JS, Chanock SJ, Kolb S, Signorello LB, Yamamura Y, Neslund-Dudas C, Thun MJ…
• Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.
  Nature genetics 2011 Haiman CA, Chen GK, Blot WJ, Strom SS, Berndt SI, Kittles RA, Rybicki BA, Isaacs WB, Ingles SA, Stanford JL, Diver WR, Witte JS, Hsing AW, Nemesure B, Rebbeck TR, Cooney KA, Xu J, Kibel AS, Hu JJ, …
• National Cancer Institute Prostate Cancer Genetics Workshop.
  Cancer research 2011 Catalona WJ, Bailey-Wilson JE, Camp NJ, Chanock SJ, Cooney KA, Easton DF, Eeles RA, FitzGerald LM, Freedman ML, Gudmundsson J, Kittles RA, Margulies EH, McGuire BB, Ostrander EA, Rebbeck TR, Stanford …
• Parallel biocomputing.
  Source code for biology and medicine 2011 Kompass KS, Hoffmann TJ, Witte JS
• Polygenic modeling of genome-wide association studies: an application to prostate and breast cancer.
  Omics : a journal of integrative biology 2011 Witte JS, Hoffmann TJ
• Co-regulatory expression quantitative trait loci mapping: method and application to endometrial cancer.
  BMC medical genomics 2011 Kompass KS, Witte JS
• Personalized prostate cancer screening: improving PSA tests with genomic information.
  Science translational medicine 2010 Witte JS
• Validation of genome-wide prostate cancer associations in men of African descent.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010 Chang BL, Spangler E, Gallagher S, Haiman CA, Henderson B, Isaacs W, Benford ML, Kidd LR, Cooney K, Strom S, Ingles SA, Stern MC, Corral R, Joshi AD, Xu J, Giri VN, Rybicki B, Neslund-Dudas C, Kibel …
• Comprehensive approach to analyzing rare genetic variants.
  PloS one 2010 Hoffmann TJ, Marini NJ, Witte JS
• Fine-mapping of prostate cancer aggressiveness loci on chromosome 7q22-35.
  The Prostate 2010 Liu X, Cheng I, Plummer SJ, Suarez BK, Casey G, Catalona WJ, Witte JS
• Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer.
  Pharmaceuticals (Basel, Switzerland) 2010 Reese AC, Hardin J, Cheng I, Casey G, Witte JS
• Segmentation and estimation for SNP microarrays: a Bayesian multiple change-point approach.
  Biometrics 2010 Tai YC, Kvale MN, Witte JS
• Prostate cancer susceptibility variants confer increased risk of disease progression.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010 Cheng I, Plummer SJ, Neslund-Dudas C, Klein EA, Casey G, Rybicki BA, Witte JS
• Conference Scene: Lessons learned from the 5th Statistical Analysis Workshop of the Pharmacogenetics Research Network.
  Pharmacogenomics 2010 Atkinson EJ, McDonnell SK, Witte JS, Crawford DC, Fan Y, Fridley B, Li D, Li L, Rodin A, Sadee W, Speed T, Weiss ST, Yang J, Yerges L, Schaid DJ
• Prostatitis, sexually transmitted diseases, and prostate cancer: the California Men's Health Study.
  PloS one 2010 Cheng I, Witte JS, Jacobsen SJ, Haque R, Quinn VP, Quesenberry CP, Caan BJ, Van Den Eeden SK
• Genome-wide association studies and beyond.
  Annual review of public health 2010 Witte JS
• VALID: visualization of association study results and linkage disequilibrium.
  Genetic epidemiology 2009 Jorgenson E, Kvale M, Witte JS
• Omega-3 fatty acids, genetic variants in COX-2 and prostate cancer.
  Journal of nutrigenetics and nutrigenomics 2009 Reese AC, Fradet V, Witte JS
• The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop.
  Genetics in medicine : official journal of the American College of Medical Genetics 2009 Khoury MJ, McBride CM, Schully SD, Ioannidis JP, Feero WG, Janssens AC, Gwinn M, Simons-Morton DG, Bernhardt JM, Cargill M, Chanock SJ, Church GM, Coates RJ, Collins FS, Croyle RT, Davis BR, Downing …
• Socioeconomic status and prostate cancer incidence and mortality rates among the diverse population of California.
  Cancer causes & control : CCC 2009 Cheng I, Witte JS, McClure LA, Shema SJ, Cockburn MG, John EM, Clarke CA
• Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Fradet V, Cheng I, Casey G, Witte JS
• Carboxypeptidase 4 gene variants and early-onset intermediate-to-high risk prostate cancer.
  BMC cancer 2009 Ross PL, Cheng I, Liu X, Cicek MS, Carroll PR, Casey G, Witte JS
• Nutrient pathways and neural tube defects: a semi-Bayesian hierarchical analysis.
  Epidemiology (Cambridge, Mass.) 2009 Carmichael SL, Witte JS, Shaw GM
• Prostate cancer genomics: towards a new understanding.
  Nature reviews. Genetics 2008 Witte JS
• New classification of chronic GVHD: added clarity from the consensus diagnoses.
  Bone marrow transplantation 2008 Arora M, Nagaraj S, Witte J, DeFor TE, MacMillan M, Burns LJ, Weisdorf DJ
• The role of genetic variation in Toll-like receptor 4 in prostate cancer susceptibility: a review.
  Expert opinion on medical diagnostics 2008 Cheng I, Witte JS
• 8q24 and prostate cancer: association with advanced disease and meta-analysis.
  European journal of human genetics : EJHG 2008 Cheng I, Plummer SJ, Jorgenson E, Liu X, Rybicki BA, Casey G, Witte JS
• An empirical evaluation of the common disease-common variant hypothesis.
  BMC proceedings 2007 Chen GK, Jorgenson E, Witte JS
• Genetic Analysis Workshop 15: gene expression analysis and approaches to detecting multiple functional loci.
  BMC proceedings 2007 Cordell HJ, de Andrade M, Babron MC, Bartlett CW, Beyene J, Bickeböller H, Culverhouse R, Cupples LA, Daw EW, Dupuis J, Falk CT, Ghosh S, Goddard KA, Goode EL, Hauser ER, Martin LJ, Martinez M, North …
• Genome-wide association studies of cancer.
  Future oncology (London, England) 2007 Jorgenson E, Witte JS
• COX2 genetic variation, NSAIDs, and advanced prostate cancer risk.
  British journal of cancer 2007 Cheng I, Liu X, Plummer SJ, Krumroy LM, Casey G, Witte JS
• Enriching the analysis of genomewide association studies with hierarchical modeling.
  American journal of human genetics 2007 Chen GK, Witte JS
• MIC1 and IL1RN genetic variation and advanced prostate cancer risk.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007 Cheng I, Krumroy LM, Plummer SJ, Casey G, Witte JS
• Multiple prostate cancer risk variants on 8q24.
  Nature genetics 2007 Witte JS
• Association of testis derived transcript gene variants and prostate cancer risk.
  The Journal of urology 2007 Liu X, Cicek MS, Plummer SJ, Jorgenson E, Casey G, Witte JS
• Dissecting effects of complex mixtures: who's afraid of informative priors?
  Epidemiology (Cambridge, Mass.) 2007 Thomas DC, Witte JS, Greenland S
• Plasminogen activator inhibitor type-1 (PAI-1) polymorphism 4G/5G is associated with prostate cancer among men with a positive family history.
  The Prostate 2007 Jorgenson E, Deitcher SR, Cicek M, Liu X, Plummer S, Casey G, Witte JS
• Toll-like receptor 4 genetic variation and advanced prostate cancer risk.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007 Cheng I, Plummer SJ, Casey G, Witte JS
• Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant.
  Carcinogenesis 2007 Liu X, Schumacher FR, Plummer SJ, Jorgenson E, Casey G, Witte JS
• Genome-wide association analyses of expression phenotypes.
  Genetic epidemiology 2007 Chen GK, Zheng T, Witte JS, Goode EL, Gao L, Hu P, Suh YJ, Suktitipat B, Szymczak S, Woo JH, Zhang W
• Introduction to Genetic Analysis Workshop 15 summaries.
  Genetic epidemiology 2007 Witte JS, Schnell AH, Cordell HJ, Spielman RS, Amos CI, Miller MB, Almasy L, MacCluer JW
• Vitamin D receptor genotypes/haplotypes and prostate cancer risk.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006 Cicek MS, Liu X, Schumacher FR, Casey G, Witte JS
• A gene-centric approach to genome-wide association studies.
  Nature reviews. Genetics 2006 Jorgenson E, Witte JS
• Nonsteroidal antiinflammatory drugs and decreased risk of advanced prostate cancer: modification by lymphotoxin alpha.
  American journal of epidemiology 2006 Liu X, Plummer SJ, Nock NL, Casey G, Witte JS
• Novel missense mutations of the Deleted-in-AZoospermia-Like (DAZL) gene in infertile women and men.
  Reproductive biology and endocrinology : RB&E 2006 Tung JY, Rosen MP, Nelson LM, Turek PJ, Witte JS, Cramer DW, Cedars MI, Reijo-Pera RA
• Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways.
  Intensive care medicine 2006 Sapru A, Wiemels JL, Witte JS, Ware LB, Matthay MA
• Polymorphisms in polycyclic aromatic hydrocarbon metabolism and conjugation genes, interactions with smoking and prostate cancer risk.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006 Nock NL, Liu X, Cicek MS, Li L, Macarie F, Rybicki BA, Plummer SJ, Maclennan GT, Casey G, Witte JS
• Polymorphisms in estrogen bioactivation, detoxification and oxidative DNA base excision repair genes and prostate cancer risk.
  Carcinogenesis 2006 Nock NL, Cicek MS, Li L, Liu X, Rybicki BA, Moreira A, Plummer SJ, Casey G, Witte JS
• Coverage and power in genomewide association studies.
  American journal of human genetics 2006 Jorgenson E, Witte JS
• Podocalyxin variants and risk of prostate cancer and tumor aggressiveness.
  Human molecular genetics 2006 Casey G, Neville PJ, Liu X, Plummer SJ, Cicek MS, Krumroy LM, Curran AP, McGreevy MR, Catalona WJ, Klein EA, Witte JS
• Hierarchical modeling in association studies of multiple phenotypes.
  BMC genetics 2005 Liu X, Jorgenson E, Witte JS
• Relationship between body size and prostate cancer in a sibling based case-control study.
  The Journal of urology 2005 Liu X, Rybicki BA, Casey G, Witte JS
• Variants in Deleted in AZoospermia-Like (DAZL) are correlated with reproductive parameters in men and women.
  Human genetics 2005 Tung JY, Rosen MP, Nelson LM, Turek PJ, Witte JS, Cramer DW, Cedars MI, Pera RA
• No association between genetic polymorphisms in insulin and insulin receptor substrate-1 and prostate cancer.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005 Li L, Cicek MS, Casey G, Witte JS
• Role of androgen metabolism genes CYP1B1, PSA/KLK3, and CYP11alpha in prostate cancer risk and aggressiveness.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005 Cicek MS, Liu X, Casey G, Witte JS
• Gene symbol: KCNQ2. Disease: Benign neonatal familial convulsion.
  Human genetics 2005 Pinto D, de Haan GJ, Carton D, Bader A, Witte J, Peters E, van Erp MG, Vandereyken W, Boezeman EH, Boon P, Halley DJ, Koeleman BP, Lindhout D
• Case-control analyses: Geneopardy!
  Genetic epidemiology 2005 Jorgenson E, Liu X, Witte JS
• No association between a tetranucleotide repeat polymorphism of CYP19 and prostate cancer.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004 Li L, Cicek MS, Casey G, Witte JS
• Increased power for case-control studies of single nucleotide polymorphisms through incorporation of family history and genetic constraints.
  Genetic epidemiology 2004 Thompson D, Witte JS, Slattery M, Goldgar D
• Relationship between methylenetetrahydrofolate reductase C677T and A1298C genotypes and haplotypes and prostate cancer risk and aggressiveness.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004 Cicek MS, Nock NL, Li L, Conti DV, Casey G, Witte JS
• Using hierarchical modeling in genetic association studies with multiple markers: application to a case-control study of bladder cancer.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004 Hung RJ, Brennan P, Malaveille C, Porru S, Donato F, Boffetta P, Witte JS
• Association of prostate cancer risk and aggressiveness to androgen pathway genes: SRD5A2, CYP17, and the AR.
  The Prostate 2004 Cicek MS, Conti DV, Curran A, Neville PJ, Paris PL, Casey G, Witte JS
• Comprehensive evaluation of the association between prostate cancer and genotypes/haplotypes in CYP17A1, CYP3A4, and SRD5A2.
  European journal of human genetics : EJHG 2004 Loukola A, Chadha M, Penn SG, Rank D, Conti DV, Thompson D, Cicek M, Love B, Bivolarevic V, Yang Q, Jiang Y, Hanzel DK, Dains K, Paris PL, Casey G, Witte JS
• Genetic dissection of complex traits with chromosome substitution strains of mice.
  Science (New York, N.Y.) 2004 Singer JB, Hill AE, Burrage LC, Olszens KR, Song J, Justice M, O'Brien WE, Conti DV, Witte JS, Lander ES, Nadeau JH
• No association between genetic polymorphisms in IGF-I and IGFBP-3 and prostate cancer.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004 Li L, Cicek MS, Casey G, Witte JS
• DNA repair gene XRCC1 and XPD polymorphisms and risk of prostate cancer.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004 Rybicki BA, Conti DV, Moreira A, Cicek M, Casey G, Witte JS
• Comparison of missing data approaches in linkage analysis.
  BMC genetics 2003 Xing C, Schumacher FR, Conti DV, Witte JS
• Genome-wide scan of brothers: replication and fine mapping of prostate cancer susceptibility and aggressiveness loci.
  The Prostate 2003 Witte JS, Suarez BK, Thiel B, Lin J, Yu A, Banerjee TK, Burmester JK, Casey G, Catalona WJ
• Relation of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 to risk of prostate cancer (United States).
  Cancer causes & control : CCC 2003 Li L, Yu H, Schumacher F, Casey G, Witte JS
• CYP3A4 and CYP3A5 genotypes, haplotypes, and risk of prostate cancer.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003 Plummer SJ, Conti DV, Paris PL, Curran AP, Casey G, Witte JS
• Prostate cancer aggressiveness locus on chromosome segment 19q12-q13.1 identified by linkage and allelic imbalance studies.
  Genes, chromosomes & cancer 2003 Neville PJ, Conti DV, Krumroy LM, Catalona WJ, Suarez BK, Witte JS, Casey G
• Hierarchical modeling of linkage disequilibrium: genetic structure and spatial relations.
  American journal of human genetics 2003 Conti DV, Witte JS
• Haplotype tagging single nucleotide polymorphisms and association studies.
  Human heredity 2003 Thompson D, Stram D, Goldgar D, Witte JS
• Analysis of mutational spectra: locating hotspots and clusters of mutations using recursive segmentation.
  Statistics in medicine 2002 Fijal BA, Idury RM, Witte JS
• Androgen receptor CAG repeats and prostate cancer.
  American journal of epidemiology 2002 Nelson KA, Witte JS
• Relation between tumour necrosis factor polymorphism TNFalpha-308 and risk of asthma.
  European journal of human genetics : EJHG 2002 Witte JS, Palmer LJ, O'Connor RD, Hopkins PJ, Hall JM
• Improvement of perineal wound healing by local administration of gentamicin-impregnated collagen fleeces after abdominoperineal excision of rectal cancer.
  American journal of surgery 2001 Gruessner U, Clemens M, Pahlplatz PV, Sperling P, Witte J, Rosen HR, Septocoll Study Group
• [Ileus in colorectal carcinoma. Preoperative implantation of self-expanding metal stents and early elective surgery as an alternative to emergency surgery].
  Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen 2001 Knöpfle E, Mayer H, Wamser G, Bohndorf K, Witte J
• Model-free linkage analysis with covariates confirms linkage of prostate cancer to chromosomes 1 and 4.
  American journal of human genetics 2001 Goddard KA, Witte JS, Suarez BK, Catalona WJ, Olson JM
• Hierarchical modeling of the relation between sequence variants and a quantitative trait: addressing multiple comparison and population stratification issues.
  Genetic epidemiology 2001 Kim LL, Fijal BA, Witte JS
• Impact of preadjusting a quantitative phenotype prior to sib-pair linkage analysis when gene x environment interaction exists.
  Genetic epidemiology 2001 Mosley J, Conti DV, Elston RC, Witte JS
• Introduction: analysis of sequence data and population structure.
  Genetic epidemiology 2001 Witte JS, Fijal BA
• Predicting quantitative trait levels by modeling SNP interaction.
  Genetic epidemiology 2001 Fijal BA, Kim LL, Buxbaum SG, Witte JS
• Multilevel modeling in epidemiology with GLIMMIX.
  Epidemiology (Cambridge, Mass.) 2000 Witte JS, Greenland S, Kim LL, Arab L
• Surgery for Graves' disease: total versus subtotal thyroidectomy-results of a prospective randomized trial.
  World journal of surgery 2000 Witte J, Goretzki PE, Dotzenrath C, Simon D, Felis P, Neubauer M, Röher HD
• Replication linkage study for prostate cancer susceptibility genes.
  The Prostate 2000 Suarez BK, Lin J, Witte JS, Conti DV, Resnick MI, Klein EA, Burmester JK, Vaske DA, Banerjee TK, Catalona WJ
• Testing drug response in the presence of genetic information: sampling issues for clinical trials.
  Pharmacogenetics 2000 Cardon LR, Idury RM, Harris TJ, Witte JS, Elston RC
• CYP3A activity in African American and European American men: population differences and functional effect of the CYP3A4*1B5'-promoter region polymorphism.
  Clinical pharmacology and therapeutics 2000 Wandel C, Witte JS, Hall JM, Stein CM, Wood AJ, Wilkinson GR
• Identification and fine mapping of a region showing a high frequency of allelic imbalance on chromosome 16q23.2 that corresponds to a prostate cancer susceptibility locus.
  Cancer research 2000 Paris PL, Witte JS, Kupelian PA, Levin H, Klein EA, Catalona WJ, Casey G
• [The AEP (Appropriateness Evaluation Protocol) procedure for the assessment of inpatient treatment needs. Evaluation from the surgery viewpoint].
  Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen 2000 Bauer H, Witte J
• Genomewide scan for prostate cancer-aggressiveness loci.
  American journal of human genetics 2000 Witte JS, Goddard KA, Conti DV, Elston RC, Lin J, Suarez BK, Broman KW, Burmester JK, Weber JL, Catalona WJ
• A genome screen of multiplex sibships with prostate cancer.
  American journal of human genetics 2000 Suarez BK, Lin J, Burmester JK, Broman KW, Weber JL, Banerjee TK, Goddard KA, Witte JS, Elston RC, Catalona WJ
• On the relative sample size required for multiple comparisons.
  Statistics in medicine 2000 Witte JS, Elston RC, Cardon LR
• Clinical trials in the genomic era: effects of protective genotypes on sample size and duration of trial.
  Controlled clinical trials 2000 Fijal BA, Hall JM, Witte JS
• Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations.
  American journal of human genetics 2000 Goddard KA, Hopkins PJ, Hall JM, Witte JS
• Sleep apnea syndrome in patients with cardiac pacemaker.
  Respiration; international review of thoracic diseases 2000 Fietze I, Röttig J, Quispe-Bravo S, Riedel F, Witte J, Baumann G, Witt C
• [Biatrial pacing as an effective therapy method of paroxysmal atrial fibrillation].
  Wiener medizinische Wochenschrift (1946) 2000 Witte J, Reibis R, Bondke HJ, Baumann G
• Genetic mapping of complex traits.
  Statistics in medicine 1999 Olson JM, Witte JS, Elston RC
• Association between a CYP3A4 genetic variant and clinical presentation in African-American prostate cancer patients.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1999 Paris PL, Kupelian PA, Hall JM, Williams TL, Levin H, Klein EA, Casey G, Witte JS
• Neonatal screening for hearing disorders in infants at risk: incidence, risk factors, and follow-up.
  Pediatrics 1999 Meyer C, Witte J, Hildmann A, Hennecke KH, Schunck KU, Maul K, Franke U, Fahnenstich H, Rabe H, Rossi R, Hartmann S, Gortner L
• The health effects of swimming in ocean water contaminated by storm drain runoff.
  Epidemiology (Cambridge, Mass.) 1999 Haile RW, Witte JS, Gold M, Cressey R, McGee C, Millikan RC, Glasser A, Harawa N, Ervin C, Harmon P, Harper J, Dermand J, Alamillo J, Barrett K, Nides M, Wang G
• Re: Biological aggressiveness of hereditary prostate cancer: long-term evaluation following radical prostatectomy.
  The Journal of urology 1999 Kupelian PA, Klein EA, Witte JS
• Asymptotic bias and efficiency in case-control studies of candidate genes and gene-environment interactions: basic family designs.
  American journal of epidemiology 1999 Witte JS, Gauderman WJ, Thomas DC
• Family-based association studies.
  Journal of the National Cancer Institute. Monographs 1999 Gauderman WJ, Witte JS, Thomas DC
• Likelihood-based approach to estimating twin concordance for dichotomous traits.
  Genetic epidemiology 1999 Witte JS, Carlin JB, Hopper JL
• Model-based and model-free multipoint genome-wide linkage analysis of alcoholism.
  Genetic epidemiology 1999 Jacobs KB, Wedig GC, Schnell AH, Witte JS, Elston RC
• Does a family history of prostate cancer result in more aggressive disease?
  Prostate cancer and prostatic diseases 1998 Klein EA, Kupelian PA, Witte JS
• Software for hierarchical modeling of epidemiologic data.
  Epidemiology (Cambridge, Mass.) 1998 Witte JS, Greenland S, Kim LL
• Evaluating the performance of a genetic test using information from previous studies in place of a gold standard.
  Medical care 1998 Fijal BA, Witte JS
• Glutathione transferase null genotype, broccoli, and lower prevalence of colorectal adenomas.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1998 Lin HJ, Probst-Hensch NM, Louie AD, Kau IH, Witte JS, Ingles SA, Frankl HD, Lee ER, Haile RW
• Monoclonal antibody therapy for resected Dukes' C colorectal cancer: seven-year outcome of a multicenter randomized trial.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998 Riethmüller G, Holz E, Schlimok G, Schmiegel W, Raab R, Höffken K, Gruber R, Funke I, Pichlmaier H, Hirche H, Buggisch P, Witte J, Pichlmayr R
• Familial prostate cancer: a different disease?
  The Journal of urology 1997 Kupelian PA, Klein EA, Witte JS, Kupelian VA, Suh JH
• A sigmoidoscopy-based case-control study of polyps: macronutrients, fiber and meat consumption.
  International journal of cancer 1997 Haile RW, Witte JS, Longnecker MP, Probst-Hensch N, Chen MJ, Harper J, Frankl HD, Lee ER
• A nested approach to evaluating dose-response and trend.
  Annals of epidemiology 1997 Witte JS, Greenland S
• Family history of prostate cancer in patients with localized prostate cancer: an independent predictor of treatment outcome.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997 Kupelian PA, Kupelian VA, Witte JS, Macklis R, Klein EA
• Plasma carotenoids and the prevalence of adenomatous polyps of the distal colon and rectum.
  American journal of epidemiology 1997 Shikany JM, Witte JS, Henning SM, Swendseid ME, Bird CL, Frankl HD, Lee ER, Haile RW
• Meat preparation and colorectal adenomas in a large sigmoidoscopy-based case-control study in California (United States).
  Cancer causes & control : CCC 1997 Probst-Hensch NM, Sinha R, Longnecker MP, Witte JS, Ingles SA, Frankl HD, Lee ER, Haile RW
• Diet and premenopausal bilateral breast cancer: a case-control study.
  Breast cancer research and treatment 1997 Witte JS, Ursin G, Siemiatycki J, Thompson WD, Paganini-Hill A, Haile RW
• Genetic analysis with hierarchical models.
  Genetic epidemiology 1997 Witte JS
• Modeling age of onset and residual familial correlations for the linkage analysis of bipolar disorder.
  Genetic epidemiology 1997 Schnell AH, Karunaratne PM, Witte JS, Dawson DV, Elston RC
• [Significance of lymph node metastases of differentiated thyroid gland carcinomas and C-cell carcinomas for prognosis--a meta-analysis].
  Zentralblatt fur Chirurgie 1997 Witte J, Schlotmann U, Simon D, Dotzenrath C, Ohmann C, Goretzki PE
• Relation of vegetable, fruit, and grain consumption to colorectal adenomatous polyps.
  American journal of epidemiology 1996 Witte JS, Longnecker MP, Bird CL, Lee ER, Frankl HD, Haile RW
• Incidence of regional recurrence guiding radicality in differentiated thyroid carcinoma.
  World journal of surgery 1996 Simon D, Goretzki PE, Witte J, Röher HD
• Agreement in alcohol consumption levels as measured by two different questionnaires.
  Journal of studies on alcohol 1996 Witte JS, Haile RW
• Plasma ferritin, iron intake, and the risk of colorectal polyps.
  American journal of epidemiology 1996 Bird CL, Witte JS, Swendseid ME, Shikany JM, Hunt IF, Frankl HD, Lee ER, Longnecker MP, Haile RW
• Transmission of Mycobacterium tuberculosis from tuberculosis patients with HIV infection or AIDS.
  American journal of epidemiology 1996 Cauthen GM, Dooley SW, Onorato IM, Ihle WW, Burr JM, Bigler WJ, Witte J, Castro KG
• Simulation study of hierarchical regression.
  Statistics in medicine 1996 Witte JS, Greenland S
• Genetic dissection of complex traits.
  Nature genetics 1996 Witte JS, Elston RC, Schork NJ
• A case-control study of reproductive variables, alcohol, and smoking in premenopausal bilateral breast cancer.
  Breast cancer research and treatment 1996 Haile RW, Witte JS, Ursin G, Siemiatycki J, Bertolli J, Douglas Thompson W, Paganini-Hill A
• Association within twin pairs for a dichotomous trait.
  Genetic epidemiology 1996 Olson JM, Witte JS, Elston RC
• Red cell and plasma folate, folate consumption, and the risk of colorectal adenomatous polyps.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1995 Bird CL, Swendseid ME, Witte JS, Shikany JM, Hunt IF, Frankl HD, Lee ER, Longnecker MP, Haile RW
• Re: "A population-based case-cohort evaluation of the efficacy of mammographic screening for breast cancer".
  American journal of epidemiology 1995 Langholz B, Thomas DC, Witte J, Peters RK
• Re: "Can energy adjustment separate the effects of energy from those of specific macronutrients?".
  American journal of epidemiology 1995 Witte JS, Pike MC
• Re: "Statistical significance testing in the American Journal of Epidemiology, 1970-1990".
  American journal of epidemiology 1995 Witte JS, Thomas DC, Langholz B
• Genetic epidemiologic analysis of quantitative phenotypes using Gibbs sampling.
  Genetic epidemiology 1995 Gauderman WJ, Witte JS, Faucett CL, Morrison J, Thomas DC
• Hierarchical regression analysis applied to a study of multiple dietary exposures and breast cancer.
  Epidemiology (Cambridge, Mass.) 1994 Witte JS, Greenland S, Haile RW, Bird CL
• [Laparoscopic cholecystectomy with the ultrasound dissector].
  Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen 1993 Lindemann F, Chen D, Witte J
• [Operative strategy in abdominal surgery in the aged: standard technics and alternatives].
  Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen 1984 Witte J, Demmel N, Wirsching R, Denecke H
• Hazardous wastes and public health: general considerations and analysis of existing data sources in Florida.
  Progress in clinical and biological research 1983 Levine RS, Chitwood D, Witte J, Mutter R, King S
• Pertinent questions about immunization.
  Pediatric nursing 1976 Witte J
• [Physical performance of patients with fixed-frequency pacemaker with reference to hemodynamics, arteriovenous oxygen difference and pulmonary function].
  Zeitschrift fur Kardiologie 1974 Eimer HH, Witte J
• Function and metabolism of canine kidneys after aerobic ischemia by retrograde persufflation with gaseous oxygen.
  Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie 1974 Isselhard W, Witte J, Denecke H, Berger M, Fischer JH, Molzberger H
• Function and metabolism of canine kidneys after aerobic ischemia by orthograde persufflation with gaseous oxygen.
  Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie 1973 Isselhard W, Denecke H, Stelter W, Berger M, Sachweh D, Witte J, Fischer JH
• Metabolism of canine kidneys in anaerobic ischemia and in aerobic ischemia by persufflation with gaseous oxygen.
  Pflugers Archiv : European journal of physiology 1972 Isselhard W, Berger M, Denecke H, Witte J, Fischer JH, Molzberger H
• [Kidney function following hypothermic aerobic ischemia in situ].
  Pflugers Archiv : European journal of physiology 1972 Isselhard W, Witte J, Denecke H, Berger M, Fischer JH
• [Renal function after hypothermic kidney ischemia with orthograde and retrograde O 2 -persulflation in situ].
  Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie 1972 Isselhard W, Denecke H, Witte J, Berger M, Fischer JH