John Wiencke, PhD
Professor
Neurological Surgery
School of Medicine

Websites

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• Profile at UCSF Cancer Center (cancer.ucsf.edu)

Grants and Projects

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• Brain Tumor SPORE Grant, NIH, 2002-2023
• Cancer Center Support Grant, NIH, 1999-2023
• Immune epigenetic biomarkers of survival in glioma epidemiology, NIH, 2017-2022
• Genetic and molecular epidemiology of adult glioma, NIH, 1991-2017
• Toxic Substances in the Environment, NIH, 1987-2017
• Biomarkers of survival in glioma epidemiology, NIH, 2008-2014
• Biomarkers of Lung Cancer Susceptibility in Minorities, NIH, 1994-2011
• Mutagen Sensitivity in High Breast Cancer Risk Patients, NIH, 1986-1990

Publications (305)

Top publication keywords:
Lung NeoplasmsGenetic Predisposition to DiseaseSister Chromatid ExchangeGlutathione TransferaseEpigenesis, GeneticPolymorphism, GeneticIsocitrate DehydrogenaseDNA AdductsGlioblastomaBrain NeoplasmsChromosome AberrationsBiomarkers, TumorPrecursor Cell Lymphoblastic Leukemia-LymphomaDNA MethylationGlioma

• Matched analysis of detailed peripheral blood and tumor immune microenvironment profiles in bladder cancer.
  Epigenomics 2024 Chen JQ, Salas LA, Wiencke JK, Koestler DC, Molinaro AM, Andrew AS, Seigne JD, Karagas MR, Kelsey KT, Christensen BC
• Genome-wide Polygenic Risk Scores Predict Risk of Glioma and Molecular Subtypes.
  medRxiv : the preprint server for health sciences 2024 Nakase T, Guerra G, Ostrom QT, Ge T, Melin B, Wrensch M, Wiencke JK, Jenkins RB, Eckel-Passow JE, Glioma International Case-Control Study (GICC), Bondy ML, Francis SS, Kachuri L
• Enrichment of a neutrophil-like monocyte transcriptional state in glioblastoma myeloid suppressor cells.
  Research square 2023 Wiencke JK, Nissen E, Koestler DC, Tamaki SJ, Tamaki CM, Hansen HM, Warrier G, Hadad S, McCoy L, Rice T, Clarke J, Taylor JW, Salas LA, Christensen BC, Kelsey KT, Butler R, Molinaro AM
• Maternal prenatal use of alcohol, tobacco, and illicit drugs and associations with childhood cancer subtypes.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2023 Wimberly CE, Gulrajani NB, Russ JB, Landi D, Wiemels JL, Towry L, Wiencke JK, Walsh KM
• Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival.
  medRxiv : the preprint server for health sciences 2023 Kachuri L, Guerra GA, Wendt GA, Hansen HM, Molinaro AM, Bracci P, McCoy L, Rice T, Wiencke JK, Eckel-Passow JE, Jenkins RB, Wrensch M, Francis SS

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• Inherited polymorphisms in the Human Leukocyte Antigen Region modify the association between varicella-zoster virus antibody reactivity and glioma prognosis.
  Neuro-oncology 2023 Francis SS, Guerra G, Hansen HM, Wendt G, Kachuri L, Wiencke JK, Wrensch M
• Genome-Scale Methylation Analysis Identifies Immune Profiles and Age Acceleration Associations with Bladder Cancer Outcomes.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2023 Chen JQ, Salas LA, Wiencke JK, Koestler DC, Molinaro AM, Andrew AS, Seigne JD, Karagas MR, Kelsey KT, Christensen BC
• Calculating detection limits and uncertainty of reference-based deconvolution of whole-blood DNA methylation data.
  Epigenomics 2023 Bell-Glenn S, Salas LA, Molinaro AM, Butler RA, Christensen BC, Kelsey KT, Wiencke JK, Koestler DC
• Hierarchical deconvolution for extensive cell type resolution in the human brain using DNA methylation.
  Frontiers in neuroscience 2023 Zhang Z, Wiencke JK, Kelsey KT, Koestler DC, Molinaro AM, Pike SC, Karra P, Christensen BC, Salas LA
• Antibodies to varicella-zoster virus and three other herpesviruses and survival in adults with glioma.
  Neuro-oncology 2023 Guerra G, McCoy L, Hansen HM, Rice T, Molinaro AM, Wiemels JL, Wiencke JK, Wrensch M, Francis SS
• Assessment of immune cell profiles among post-menopausal women in the Women's Health Initiative using DNA methylation-based methods.
  Clinical epigenetics 2023 Nissen E, Reiner A, Liu S, Wallace RB, Molinaro AM, Salas LA, Christensen BC, Wiencke JK, Koestler DC, Kelsey KT
• Interactive Effects of Molecular, Therapeutic, and Patient Factors on Outcome of Diffuse Low-Grade Glioma.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2023 Hervey-Jumper SL, Zhang Y, Phillips JJ, Morshed RA, Young JS, McCoy L, Lafontaine M, Luks T, Ammanuel S, Kakaizada S, Egladyous A, Gogos A, Villanueva-Meyer J, Shai A, Warrier G, Rice T, Crane J, …
• Comparative analysis of the DNA methylation landscape in CD4, CD8, and B memory lineages.
  Clinical epigenetics 2022 Zhang Z, Butler R, Koestler DC, Bell-Glenn S, Warrier G, Molinaro AM, Christensen BC, Wiencke JK, Kelsey KT, Salas LA
• HiTIMED: hierarchical tumor immune microenvironment epigenetic deconvolution for accurate cell type resolution in the tumor microenvironment using tumor-type-specific DNA methylation data.
  Journal of translational medicine 2022 Zhang Z, Wiencke JK, Kelsey KT, Koestler DC, Christensen BC, Salas LA
• Evaluation of cross-platform compatibility of a DNA methylation-based glucocorticoid response biomarker.
  Clinical epigenetics 2022 Tang E, Wiencke JK, Warrier G, Hansen H, McCoy L, Rice T, Bracci PM, Wrensch M, Taylor JW, Clarke JL, Koestler DC, Salas LA, Christensen BC, Kelsey KT, Molinaro AM
• A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation.
  Science (New York, N.Y.) 2022 Yanchus C, Drucker KL, Kollmeyer TM, Tsai R, Winick-Ng W, Liang M, Malik A, Pawling J, De Lorenzo SB, Ali A, Decker PA, Kosel ML, Panda A, Al-Zahrani KN, Jiang L, Browning JWL, Lowden C, Geuenich M, …
• Prospective genomically guided identification of "early/evolving" and "undersampled" IDH-wildtype glioblastoma leads to improved clinical outcomes.
  Neuro-oncology 2022 Zhang Y, Lucas CG, Young JS, Morshed RA, McCoy L, Oberheim Bush NA, Taylor JW, Daras M, Butowski NA, Villanueva-Meyer JE, Cha S, Wrensch M, Wiencke JK, Lee JC, Pekmezci M, Phillips JJ, Perry A, Bollen…
• DNA methylation as a pharmacodynamic marker of glucocorticoid response and glioma survival.
  Nature communications 2022 Wiencke JK, Molinaro AM, Warrier G, Rice T, Clarke J, Taylor JW, Wrensch M, Hansen H, McCoy L, Tang E, Tamaki SJ, Tamaki CM, Nissen E, Bracci P, Salas LA, Koestler DC, Christensen BC, Zhang Z, Kelsey …
• Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.
  Nature genetics 2022 Byun J, Han Y, Li Y, Xia J, Long E, Choi J, Xiao X, Zhu M, Zhou W, Sun R, Bossé Y, Song Z, Schwartz A, Lusk C, Rafnar T, Stefansson K, Zhang T, Zhao W, Pettit RW, Liu Y, Li X, Zhou H, Walsh KM, Gorlov…
• Pre-surgery immune profiles of adult glioma patients.
  Journal of neuro-oncology 2022 Bracci PM, Rice T, Hansen HM, Francis SS, Lee S, McCoy LS, Shrestha PP, Warrier G, Clarke JL, Molinaro AM, Taylor JW, Wiencke JK, Wrensch MR
• The immunogenetics of viral antigen response is associated with subtype-specific glioma risk and survival.
  American journal of human genetics 2022 Guerra G, Kachuri L, Wendt G, Hansen HM, Mack SJ, Molinaro AM, Rice T, Bracci P, Wiencke JK, Kasahara N, Eckel-Passow JE, Jenkins RB, Wrensch M, Francis SS
• Interactions of Age and Blood Immune Factors and Noninvasive Prediction of Glioma Survival.
  Journal of the National Cancer Institute 2022 Molinaro AM, Wiencke JK, Warrier G, Koestler DC, Chunduru P, Lee JY, Hansen HM, Lee S, Anguiano J, Rice T, Bracci PM, McCoy L, Salas LA, Christensen BC, Wrensch M, Kelsey KT, Taylor JW, Clarke JL
• A core of differentially methylated CpG loci in gMDSCs isolated from neonatal and adult sources.
  Clinical epigenetics 2022 Berglund-Brown I, Nissen E, Koestler DC, Butler RA, Eliot MN, Padbury JF, Salas LA, Molinaro AM, Christensen BC, Wiencke JK, Kelsey KT
• Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling.
  Nature communications 2022 Salas LA, Zhang Z, Koestler DC, Butler RA, Hansen HM, Molinaro AM, Wiencke JK, Kelsey KT, Christensen BC
• Immune profiles and DNA methylation alterations related with non-muscle-invasive bladder cancer outcomes.
  Clinical epigenetics 2022 Chen JQ, Salas LA, Wiencke JK, Koestler DC, Molinaro AM, Andrew AS, Seigne JD, Karagas MR, Kelsey KT, Christensen BC
• Identification of a foetal epigenetic compartment in adult human kidney.
  Epigenetics 2021 Wiencke JK, Zhang Z, Koestler DC, Salas LA, Molinaro AM, Christensen BC, Kelsey KT
• Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry.
  American journal of human genetics 2021 Graff M, Justice AE, Young KL, Marouli E, Zhang X, Fine RS, Lim E, Buchanan V, Rand K, Feitosa MF, Wojczynski MK, Yanek LR, Shao Y, Rohde R, Adeyemo AA, Aldrich MC, Allison MA, Ambrosone CB, Ambs S, …
• Adult diffuse glioma GWAS by molecular subtype identifies variants in D2HGDH and FAM20C.
  Neuro-oncology 2020 Eckel-Passow JE, Drucker KL, Kollmeyer TM, Kosel ML, Decker PA, Molinaro AM, Rice T, Praska CE, Clark L, Caron A, Abyzov A, Batzler A, Song JS, Pekmezci M, Hansen HM, McCoy LS, Bracci PM, Wiemels J, …
• Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.
  Nature communications 2020 Zhang YD, Hurson AN, Zhang H, Choudhury PP, Easton DF, Milne RL, Simard J, Hall P, Michailidou K, Dennis J, Schmidt MK, Chang-Claude J, Gharahkhani P, Whiteman D, Campbell PT, Hoffmeister M, Jenkins M…
• Association of Maximal Extent of Resection of Contrast-Enhanced and Non-Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnosed Glioblastoma.
  JAMA oncology 2020 Molinaro AM, Hervey-Jumper S, Morshed RA, Young J, Han SJ, Chunduru P, Zhang Y, Phillips JJ, Shai A, Lafontaine M, Crane J, Chandra A, Flanigan P, Jahangiri A, Cioffi G, Ostrom Q, Anderson JE, Badve C…
• Could Methylation Cytometry Be a Predictive Biomarker of Breast Cancer?
  JAMA network open 2020 Wiencke JK
• Immune factors preceding diagnosis of glioma: a Prostate Lung Colorectal Ovarian Cancer Screening Trial nested case-control study.
  Neuro-oncology advances 2019 Muskens IS, Zhou M, Mccoy L, Bracci PM, Hansen HM, Gauderman WJ, Wiencke JK, Wrensch MR, Wiemels JL
• Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data.
  Clinical epigenetics 2019 Gervin K, Salas LA, Bakulski KM, van Zelm MC, Koestler DC, Wiencke JK, Duijts L, Moll HA, Kelsey KT, Kobor MS, Lyle R, Christensen BC, Felix JF, Jones MJ
• Absence of an embryonic stem cell DNA methylation signature in human cancer.
  BMC cancer 2019 Zhang Z, Wiencke JK, Koestler DC, Salas LA, Christensen BC, Kelsey KT
• Genetic and molecular epidemiology of adult diffuse glioma.
  Nature reviews. Neurology 2019 Molinaro AM, Taylor JW, Wiencke JK, Wrensch MR
• Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics.
  International journal of cancer 2019 Ostrom QT, Egan KM, Nabors LB, Gerke T, Thompson RC, Olson JJ, LaRocca R, Chowdhary S, Eckel-Passow JE, Armstrong G, Wiencke JK, Bernstein JL, Claus EB, Il'yasova D, Johansen C, Lachance DH, Lai RK, …
• Cross-Cancer Pleiotropic Associations with Lung Cancer Risk in African Americans.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2019 Jones CC, Bradford Y, Amos CI, Blot WJ, Chanock SJ, Harris CC, Schwartz AG, Spitz MR, Wiencke JK, Wrensch MR, Wu X, Aldrich MC
• Using germline variants to estimate glioma and subtype risks.
  Neuro-oncology 2019 Eckel-Passow JE, Decker PA, Kosel ML, Kollmeyer TM, Molinaro AM, Rice T, Caron AA, Drucker KL, Praska CE, Pekmezci M, Hansen HM, McCoy LS, Bracci PM, Erickson BJ, Lucchinetti CF, Wiemels JL, Wiencke …
• Sex-specific gene and pathway modeling of inherited glioma risk.
  Neuro-oncology 2019 Ostrom QT, Coleman W, Huang W, Rubin JB, Lathia JD, Berens ME, Speyer G, Liao P, Wrensch MR, Eckel-Passow JE, Armstrong G, Rice T, Wiencke JK, McCoy LS, Hansen HM, Amos CI, Bernstein JL, Claus EB, …
• Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.
  International journal of cancer 2018 Ostrom QT, Kinnersley B, Armstrong G, Rice T, Chen Y, Wiencke JK, McCoy LS, Hansen HM, Amos CI, Bernstein JL, Claus EB, Eckel-Passow JE, Il'yasova D, Johansen C, Lachance DH, Lai RK, Merrell RT, Olson…
• Tracing human stem cell lineage during development using DNA methylation.
  Genome research 2018 Salas LA, Wiencke JK, Koestler DC, Zhang Z, Christensen BC, Kelsey KT
• An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray.
  Genome biology 2018 Salas LA, Koestler DC, Butler RA, Hansen HM, Wiencke JK, Kelsey KT, Christensen BC
• Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.
  Scientific reports 2018 Ostrom QT, Kinnersley B, Wrensch MR, Eckel-Passow JE, Armstrong G, Rice T, Chen Y, Wiencke JK, McCoy LS, Hansen HM, Amos CI, Bernstein JL, Claus EB, Il'yasova D, Johansen C, Lachance DH, Lai RK, …
• Immunomethylomics: A Novel Cancer Risk Prediction Tool.
  Annals of the American Thoracic Society 2018 Kelsey KT, Wiencke JK
• Germline polymorphisms in myeloid-associated genes are not associated with survival in glioma patients.
  Journal of neuro-oncology 2017 Jacobs DI, Liu Y, Gabrusiewicz K, Tsavachidis S, Armstrong GN, Zhou R, Wei J, Ivan C, Calin G, Molinaro AM, Rice T, Bracci PM, Hansen HM, Wiencke JK, Wrensch MR, Heimberger AB, Bondy ML
• Non-additive and epistatic effects of HLA polymorphisms contributing to risk of adult glioma.
  Journal of neuro-oncology 2017 Zhang C, de Smith AJ, Smirnov IV, Wiencke JK, Wiemels JL, Witte JS, Walsh KM
• Germline Genetic Variants and Lung Cancer Survival in African Americans.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2017 Jones CC, Bush WS, Crawford DC, Wenzlaff AS, Schwartz AG, Wiencke JK, Wrensch MR, Blot WJ, Chanock SJ, Grogan EL, Aldrich MC
• Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
  JAMA oncology 2017 Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP,…
• Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
  Nature genetics 2017 Melin BS, Barnholtz-Sloan JS, Wrensch MR, Johansen C, Il'yasova D, Kinnersley B, Ostrom QT, Labreche K, Chen Y, Armstrong G, Liu Y, Eckel-Passow JE, Decker PA, Labussière M, Idbaih A, Hoang-Xuan K, Di…
• Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT.
  Acta neuropathologica 2017 Pekmezci M, Rice T, Molinaro AM, Walsh KM, Decker PA, Hansen H, Sicotte H, Kollmeyer TM, McCoy LS, Sarkar G, Perry A, Giannini C, Tihan T, Berger MS, Wiemels JL, Bracci PM, Eckel-Passow JE, Lachance …
• Immunomethylomic approach to explore the blood neutrophil lymphocyte ratio (NLR) in glioma survival.
  Clinical epigenetics 2017 Wiencke JK, Koestler DC, Salas LA, Wiemels JL, Roy RP, Hansen HM, Rice T, McCoy LS, Bracci PM, Molinaro AM, Kelsey KT, Wrensch MR, Christensen BC
• DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio: An Epigenetic Tool to Explore Cancer Inflammation and Outcomes.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2016 Koestler DC, Usset J, Christensen BC, Marsit CJ, Karagas MR, Kelsey KT, Wiencke JK
• Enlarged leukocyte referent libraries can explain additional variance in blood-based epigenome-wide association studies.
  Epigenomics 2016 Kim S, Eliot M, Koestler DC, Houseman EA, Wetmur JG, Wiencke JK, Kelsey KT
• Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes - A Meta-Analysis.
  EBioMedicine 2016 Chen LS, Baker T, Hung RJ, Horton A, Culverhouse R, Hartz S, Saccone N, Cheng I, Deng B, Han Y, Hansen HM, Horsman J, Kim C, Rosenberger A, Aben KK, Andrew AS, Chang SC, Saum KU, Dienemann H, …
• Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome.
  Nature communications 2016 Machiela MJ, Zhou W, Karlins E, Sampson JN, Freedman ND, Yang Q, Hicks B, Dagnall C, Hautman C, Jacobs KB, Abnet CC, Aldrich MC, Amos C, Amundadottir LT, Arslan AA, Beane-Freeman LE, Berndt SI, Black …
• Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2016 Ojha J, Codd V, Nelson CP, Samani NJ, Smirnov IV, Madsen NR, Hansen HM, de Smith AJ, Bracci PM, Wiencke JK, Wrensch MR, Wiemels JL, Walsh KM, ENGAGE Consortium Telomere Group
• Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population.
  Lung cancer (Amsterdam, Netherlands) 2016 Zanetti KA, Wang Z, Aldrich M, Amos CI, Blot WJ, Bowman ED, Burdette L, Cai Q, Caporaso N, Chung CC, Gillanders EM, Haiman CA, Hansen HM, Henderson BE, Kolonel LN, Marchand LL, Li S, McNeill LH, Ryan …
• The DNA methylation profile of activated human natural killer cells.
  Epigenetics 2016 Wiencke JK, Butler R, Hsuang G, Eliot M, Kim S, Sepulveda MA, Siegel D, Houseman EA, Kelsey KT
• Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL).
  BMC bioinformatics 2016 Koestler DC, Jones MJ, Usset J, Christensen BC, Butler RA, Kobor MS, Wiencke JK, Kelsey KT
• Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans.
  EBioMedicine 2016 David SP, Wang A, Kapphahn K, Hedlin H, Desai M, Henderson M, Yang L, Walsh KM, Schwartz AG, Wiencke JK, Spitz MR, Wenzlaff AS, Wrensch MR, Eaton CB, Furberg H, Mark Brown W, Goldstein BA, Assimes T, …
• Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk.
  Oncotarget 2015 Walsh KM, Codd V, Rice T, Nelson CP, Smirnov IV, McCoy LS, Hansen HM, Elhauge E, Ojha J, Francis SS, Madsen NR, Bracci PM, Pico AR, Molinaro AM, Tihan T, Berger MS, Chang SM, Prados MD, Jenkins RB, …
• Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA.
  PloS one 2015 de Smith AJ, Walsh KM, Hansen HM, Endicott AA, Wiencke JK, Metayer C, Wiemels JL
• A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution.
  Cancer research 2015 Walsh KM, de Smith AJ, Hansen HM, Smirnov IV, Gonseth S, Endicott AA, Xiao J, Rice T, Fu CH, McCoy LS, Lachance DH, Eckel-Passow JE, Wiencke JK, Jenkins RB, Wrensch MR, Ma X, Metayer C, Wiemels JL
• Understanding the Role of the Immune System in the Development of Cancer: New Opportunities for Population-Based Research.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2015 Michaud DS, Houseman EA, Marsit CJ, Nelson HH, Wiencke JK, Kelsey KT
• Understanding inherited genetic risk of adult glioma - a review.
  Neuro-oncology practice 2015 Rice T, Lachance DH, Molinaro AM, Eckel-Passow JE, Walsh KM, Barnholtz-Sloan J, Ostrom QT, Francis SS, Wiemels J, Jenkins RB, Wiencke JK, Wrensch MR
• Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors.
  The New England journal of medicine 2015 Eckel-Passow JE, Lachance DH, Molinaro AM, Walsh KM, Decker PA, Sicotte H, Pekmezci M, Rice T, Kosel ML, Smirnov IV, Sarkar G, Caron AA, Kollmeyer TM, Praska CE, Chada AR, Halder C, Hansen HM, McCoy …
• DNA Methylation in Whole Blood: Uses and Challenges.
  Current environmental health reports 2015 Houseman EA, Kim S, Kelsey KT, Wiencke JK
• Telomere maintenance and the etiology of adult glioma.
  Neuro-oncology 2015 Walsh KM, Wiencke JK, Lachance DH, Wiemels JL, Molinaro AM, Eckel-Passow JE, Jenkins RB, Wrensch MR
• Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.
  Science (New York, N.Y.) 2015 Bell RJ, Rube HT, Kreig A, Mancini A, Fouse SD, Nagarajan RP, Choi S, Hong C, He D, Pekmezci M, Wiencke JK, Wrensch MR, Chang SM, Walsh KM, Myong S, Song JS, Costello JF
• CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization Grades II-III) astrocytomas.
  Journal of neuropathology and experimental neurology 2015 Reis GF, Pekmezci M, Hansen HM, Rice T, Marshall RE, Molinaro AM, Phillips JJ, Vogel H, Wiencke JK, Wrensch MR, Walsh KM, Perry A
• CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis--a meta-analysis.
  Journal of the National Cancer Institute 2015 Chen LS, Hung RJ, Baker T, Horton A, Culverhouse R, Saccone N, Cheng I, Deng B, Han Y, Hansen HM, Horsman J, Kim C, Lutz S, Rosenberger A, Aben KK, Andrew AS, Breslau N, Chang SC, Dieffenbach AK, …
• Cell-composition effects in the analysis of DNA methylation array data: a mathematical perspective.
  BMC bioinformatics 2015 Houseman EA, Kelsey KT, Wiencke JK, Marsit CJ
• Characterization of large structural genetic mosaicism in human autosomes.
  American journal of human genetics 2015 Machiela MJ, Zhou W, Sampson JN, Dean MC, Jacobs KB, Black A, Brinton LA, Chang IS, Chen C, Chen C, Chen K, Cook LS, Crous Bou M, De Vivo I, Doherty J, Friedenreich CM, Gaudet MM, Haiman CA, Hankinson…
• Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures.
  Nucleic acids research 2015 Lee ST, Muench MO, Fomin ME, Xiao J, Zhou M, de Smith A, Martín-Subero JI, Heath S, Houseman EA, Roy R, Wrensch M, Wiencke J, Metayer C, Wiemels JL
• Serum macrophage-derived chemokine/CCL22 levels are associated with glioma risk, CD4 T cell lymphopenia and survival time.
  International journal of cancer 2015 Zhou M, Bracci PM, McCoy LS, Hsuang G, Wiemels JL, Rice T, Zheng S, Kelsey KT, Wrensch MR, Wiencke JK
• Survival and low-grade glioma: the emergence of genetic information.
  Neurosurgical focus 2015 Claus EB, Walsh KM, Wiencke JK, Molinaro AM, Wiemels JL, Schildkraut JM, Bondy ML, Berger M, Jenkins R, Wrensch M
• A steroid metabolizing gene variant in a polyfactorial model improves risk prediction in a high incidence breast cancer population.
  BBA clinical 2014 Jupe ER, Dalessandri KM, Mulvihill JJ, Miike R, Knowlton NS, Pugh TW, Zhao LP, DeFreese DC, Manjeshwar S, Gramling BA, Wiencke JK, Benz CC
• A comparison of DNA methylation specific droplet digital PCR (ddPCR) and real time qPCR with flow cytometry in characterizing human T cells in peripheral blood.
  Epigenetics 2014 Wiencke JK, Bracci PM, Hsuang G, Zheng S, Hansen H, Wrensch MR, Rice T, Eliot M, Kelsey KT
• Genome-wide scan of 29,141 African Americans finds no evidence of directional selection since admixture.
  American journal of human genetics 2014 Bhatia G, Tandon A, Patterson N, Aldrich MC, Ambrosone CB, Amos C, Bandera EV, Berndt SI, Bernstein L, Blot WJ, Bock CH, Caporaso N, Casey G, Deming SL, Diver WR, Gapstur SM, Gillanders EM, Harris CC,…
• Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.
  Human molecular genetics 2014 Wang Z, Zhu B, Zhang M, Parikh H, Jia J, Chung CC, Sampson JN, Hoskins JW, Hutchinson A, Burdette L, Ibrahim A, Hautman C, Raj PS, Abnet CC, Adjei AA, Ahlbom A, Albanes D, Allen NE, Ambrosone CB, …
• Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.
  Nature genetics 2014 Walsh KM, Codd V, Smirnov IV, Rice T, Decker PA, Hansen HM, Kollmeyer T, Kosel ML, Molinaro AM, McCoy LS, Bracci PM, Cabriga BS, Pekmezci M, Zheng S, Wiemels JL, Pico AR, Tihan T, Berger MS, Chang SM,…
• A novel approach to the discovery of survival biomarkers in glioblastoma using a joint analysis of DNA methylation and gene expression.
  Epigenetics 2014 Smith AA, Huang YT, Eliot M, Houseman EA, Marsit CJ, Wiencke JK, Kelsey KT
• Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients.
  Epigenetics 2014 Langevin SM, Houseman EA, Accomando WP, Koestler DC, Christensen BC, Nelson HH, Karagas MR, Marsit CJ, Wiencke JK, Kelsey KT
• Quantitative reconstruction of leukocyte subsets using DNA methylation.
  Genome biology 2014 Accomando WP, Wiencke JK, Houseman EA, Nelson HH, Kelsey KT
• PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia.
  International journal of cancer 2014 Xiao J, Lee ST, Xiao Y, Ma X, Houseman EA, Hsu LI, Roy R, Wrensch M, de Smith AJ, Chokkalingam A, Buffler P, Wiencke JK, Wiemels JL
• Interaction of allergy history and antibodies to specific varicella-zoster virus proteins on glioma risk.
  International journal of cancer 2013 Lee ST, Bracci P, Zhou M, Rice T, Wiencke J, Wrensch M, Wiemels J
• SNP association mapping across the extended major histocompatibility complex and risk of B-cell precursor acute lymphoblastic leukemia in children.
  PloS one 2013 Urayama KY, Chokkalingam AP, Metayer C, Hansen H, May S, Ramsay P, Wiemels JL, Wiencke JK, Trachtenberg E, Thompson P, Ishida Y, Brennan P, Jolly KW, Termuhlen AM, Taylor M, Barcellos LF, Buffler PA
• Socioeconomic status and lung cancer: unraveling the contribution of genetic admixture.
  American journal of public health 2013 Aldrich MC, Selvin S, Wrensch MR, Sison JD, Hansen HM, Quesenberry CP, Seldin MF, Barcellos LF, Buffler PA, Wiencke JK
• Blood-based profiles of DNA methylation predict the underlying distribution of cell types: a validation analysis.
  Epigenetics 2013 Koestler DC, Christensen B, Karagas MR, Marsit CJ, Langevin SM, Kelsey KT, Wiencke JK, Houseman EA
• Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis.
  Neuro-oncology 2013 Walsh KM, Rice T, Decker PA, Kosel ML, Kollmeyer T, Hansen HM, Zheng S, McCoy LS, Bracci PM, Anderson E, Hsuang G, Wiemels JL, Pico AR, Smirnov I, Molinaro AM, Tihan T, Berger MS, Chang SM, Prados MD,…
• Associations between genome-wide Native American ancestry, known risk alleles and B-cell ALL risk in Hispanic children.
  Leukemia 2013 Walsh KM, Chokkalingam AP, Hsu LI, Metayer C, de Smith AJ, Jacobs DI, Dahl GV, Loh ML, Smirnov IV, Bartley K, Ma X, Wiencke JK, Barcellos LF, Wiemels JL, Buffler PA
• A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
  Nature genetics 2013 Monda KL, Chen GK, Taylor KC, Palmer C, Edwards TL, Lange LA, Ng MC, Adeyemo AA, Allison MA, Bielak LF, Chen G, Graff M, Irvin MR, Rhie SK, Li G, Liu Y, Liu Y, Lu Y, Nalls MA, Sun YV, Wojczynski MK, …
• Pyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma.
  PloS one 2013 Mukherjee J, Phillips JJ, Zheng S, Wiencke J, Ronen SM, Pieper RO
• Inherited variant on chromosome 11q23 increases susceptibility to IDH-mutated but not IDH-normal gliomas regardless of grade or histology.
  Neuro-oncology 2013 Rice T, Zheng S, Decker PA, Walsh KM, Bracci P, Xiao Y, McCoy LS, Smirnov I, Patoka JS, Hansen HM, Hsuang G, Wiemels JL, Tihan T, Pico AR, Prados MD, Chang SM, Berger MS, Caron A, Fink S, Kollmeyer T,…
• Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studies.
  Genetic epidemiology 2012 Walsh KM, Anderson E, Hansen HM, Decker PA, Kosel ML, Kollmeyer T, Rice T, Zheng S, Xiao Y, Chang JS, McCoy LS, Bracci PM, Wiemels JL, Pico AR, Smirnov I, Lachance DH, Sicotte H, Eckel-Passow JE, …
• Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2012 Walsh KM, Gorlov IP, Hansen HM, Wu X, Spitz MR, Zhang H, Lu EY, Wenzlaff AS, Sison JD, Wei C, Lloyd SM, Chen W, Frazier ML, Seldin MF, Bierut LJ, Bracci PM, Wrensch MR, Schwartz AG, Wiencke JK, Amos …
• Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans.
  Oncotarget 2012 Walsh KM, Amos CI, Wenzlaff AS, Gorlov IP, Sison JD, Wu X, Spitz MR, Hansen HM, Lu EY, Wei C, Zhang H, Chen W, Lloyd SM, Frazier ML, Bracci PM, Seldin MF, Wrensch MR, Schwartz AG, Wiencke JK
• Epigenetic biomarkers of T-cells in human glioma.
  Epigenetics 2012 Wiencke JK, Accomando WP, Zheng S, Patoka J, Dou X, Phillips JJ, Hsuang G, Christensen BC, Houseman EA, Koestler DC, Bracci P, Wiemels JL, Wrensch M, Nelson HH, Kelsey KT
• A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network.
  Nucleic acids research 2012 Lee ST, Xiao Y, Muench MO, Xiao J, Fomin ME, Wiencke JK, Zheng S, Dou X, de Smith A, Chokkalingam A, Buffler P, Ma X, Wiemels JL
• Leveraging ethnic group incidence variation to investigate genetic susceptibility to glioma: a novel candidate SNP approach.
  Frontiers in genetics 2012 Jacobs DI, Walsh KM, Wrensch M, Wiencke J, Jenkins R, Houlston RS, Bondy M, Simon M, Sanson M, Gousias K, Schramm J, Labussière M, Di Stefano AL, Wichmann HE, Müller-Nurasyid M, Schreiber S, Franke A,…
• Decreased NK cells in patients with head and neck cancer determined in archival DNA.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Accomando WP, Wiencke JK, Houseman EA, Butler RA, Zheng S, Nelson HH, Kelsey KT
• Previous lung diseases and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium.
  American journal of epidemiology 2012 Brenner DR, Boffetta P, Duell EJ, Bickeböller H, Rosenberger A, McCormack V, Muscat JE, Yang P, Wichmann HE, Brueske-Hohlfeld I, Schwartz AG, Cote ML, Tjønneland A, Friis S, Le Marchand L, Zhang ZF, …
• Cigarette smoking associated with lung adenocarcinoma in situ in a large case-control study (SFBALCS).
  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012 Bracci PM, Sison J, Hansen H, Walsh KM, Quesenberry CP, Raz DJ, Wrensch M, Wiencke JK
• A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation.
  Nature genetics 2012 Jenkins RB, Xiao Y, Sicotte H, Decker PA, Kollmeyer TM, Hansen HM, Kosel ML, Zheng S, Walsh KM, Rice T, Bracci P, McCoy LS, Smirnov I, Patoka JS, Hsuang G, Wiemels JL, Tihan T, Pico AR, Prados MD, …
• HLA-DP genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia risk.
  Blood 2012 Urayama KY, Chokkalingam AP, Metayer C, Ma X, Selvin S, Barcellos LF, Wiemels JL, Wiencke JK, Taylor M, Brennan P, Dahl GV, Moonsamy P, Erlich HA, Trachtenberg E, Buffler PA
• Genome-wide association study of glioma and meta-analysis.
  Human genetics 2012 Rajaraman P, Melin BS, Wang Z, McKean-Cowdin R, Michaud DS, Wang SS, Bondy M, Houlston R, Jenkins RB, Wrensch M, Yeager M, Ahlbom A, Albanes D, Andersson U, Freeman LE, Buring JE, Butler MA, Braganza …
• Vitamin D receptor polymorphisms and breast cancer risk in a high-incidence population: a pilot study.
  Journal of the American College of Surgeons 2012 Dalessandri KM, Miike R, Wiencke JK, Farren G, Pugh TW, Manjeshwar S, DeFreese DC, Jupe ER
• Fetal growth and body size genes and risk of childhood acute lymphoblastic leukemia.
  Cancer causes & control : CCC 2012 Chokkalingam AP, Metayer C, Scelo G, Chang JS, Schiffman J, Urayama KY, Ma X, Hansen HM, Feusner JH, Barcellos LF, Wiencke JK, Wiemels JL, Buffler PA
• PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome.
  Neuro-oncology 2012 Mueller S, Phillips J, Onar-Thomas A, Romero E, Zheng S, Wiencke JK, McBride SM, Cowdrey C, Prados MD, Weiss WA, Berger MS, Gupta N, Haas-Kogan DA
• Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancers.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2012 Koestler DC, Marsit CJ, Christensen BC, Accomando W, Langevin SM, Houseman EA, Nelson HH, Karagas MR, Wiencke JK, Kelsey KT
• Variation in xenobiotic transport and metabolism genes, household chemical exposures, and risk of childhood acute lymphoblastic leukemia.
  Cancer causes & control : CCC 2012 Chokkalingam AP, Metayer C, Scelo GA, Chang JS, Urayama KY, Aldrich MC, Guha N, Hansen HM, Dahl GV, Barcellos LF, Wiencke JK, Wiemels JL, Buffler PA
• Key epigenetic changes associated with lung cancer development: results from dense methylation array profiling.
  Epigenetics 2012 Nelson HH, Marsit CJ, Christensen BC, Houseman EA, Kontic M, Wiemels JL, Karagas MR, Wrensch MR, Zheng S, Wiencke JK, Kelsey KT
• DNA methylation arrays as surrogate measures of cell mixture distribution.
  BMC bioinformatics 2012 Houseman EA, Accomando WP, Koestler DC, Christensen BC, Marsit CJ, Nelson HH, Wiencke JK, Kelsey KT
• Detectable clonal mosaicism and its relationship to aging and cancer.
  Nature genetics 2012 Jacobs KB, Yeager M, Zhou W, Wacholder S, Wang Z, Rodriguez-Santiago B, Hutchinson A, Deng X, Liu C, Horner MJ, Cullen M, Epstein CG, Burdett L, Dean MC, Chatterjee N, Sampson J, Chung CC, Kovaks J, …
• Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25.
  Genetic epidemiology 2012 Chen LS, Saccone NL, Culverhouse RC, Bracci PM, Chen CH, Dueker N, Han Y, Huang H, Jin G, Kohno T, Ma JZ, Przybeck TR, Sanders AR, Smith JA, Sung YJ, Wenzlaff AS, Wu C, Yoon D, Chen YT, Cheng YC, Cho …
• SSBP2 variants are associated with survival in glioblastoma patients.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Xiao Y, Decker PA, Rice T, McCoy LS, Smirnov I, Patoka JS, Hansen HM, Wiemels JL, Tihan T, Prados MD, Chang SM, Berger MS, Kosel ML, Fridley BL, Lachance DH, O'Neill BP, Buckner JC, Thompson RC, …
• Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium.
  European journal of cancer (Oxford, England : 1990) 2012 Coté ML, Liu M, Bonassi S, Neri M, Schwartz AG, Christiani DC, Spitz MR, Muscat JE, Rennert G, Aben KK, Andrew AS, Bencko V, Bickeböller H, Boffetta P, Brennan P, Brenner H, Duell EJ, Fabianova E, …
• Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association study.
  Epigenetics 2012 Langevin SM, Koestler DC, Christensen BC, Butler RA, Wiencke JK, Nelson HH, Houseman EA, Marsit CJ, Kelsey KT
• Asthma and lung cancer risk: a systematic investigation by the International Lung Cancer Consortium.
  Carcinogenesis 2011 Rosenberger A, Bickeböller H, McCormack V, Brenner DR, Duell EJ, Tjønneland A, Friis S, Muscat JE, Yang P, Wichmann HE, Heinrich J, Szeszenia-Dabrowska N, Lissowska J, Zaridze D, Rudnai P, Fabianova E…
• History of Parvovirus B19 infection is associated with a DNA methylation signature in childhood acute lymphoblastic leukemia.
  Epigenetics 2011 Vasconcelos GM, Christensen BC, Houseman EA, Xiao J, Marsit CJ, Wiencke JK, Zheng S, Karagas MR, Nelson HH, Wrensch MR, Kelsey KT, Pombo-de-Oliveira MS, Wiemels JL
• Haplotypes of DNA repair and cell cycle control genes, X-ray exposure, and risk of childhood acute lymphoblastic leukemia.
  Cancer causes & control : CCC 2011 Chokkalingam AP, Bartley K, Wiemels JL, Metayer C, Barcellos LF, Hansen HM, Aldrich MC, Guha N, Urayama KY, Scélo G, Chang JS, Month SR, Wiencke JK, Buffler PA
• Matching on Race and Ethnicity in Case-Control Studies as a Means of Control for Population Stratification.
  Epidemiology (Sunnyvale, Calif.) 2011 Chokkalingam AP, Aldrich MC, Bartley K, Hsu LI, Metayer C, Barcellos LF, Wiemels JL, Wiencke JK, Buffler PA, Selvin S
• A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.
  Nature genetics 2011 Stacey SN, Sulem P, Jonasdottir A, Masson G, Gudmundsson J, Gudbjartsson DF, Magnusson OT, Gudjonsson SA, Sigurgeirsson B, Thorisdottir K, Ragnarsson R, Benediktsdottir KR, Nexø BA, Tjønneland A, …
• Risk of squamous cell carcinoma of the skin in relation to IgE: a nested case-control study.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2011 Wiemels JL, Wiencke JK, Li Z, Ramos C, Nelson HH, Karagas MR
• A case-control study of asphalt and tar exposure and lung cancer in minorities.
  American journal of industrial medicine 2011 McClean MD, Kelsey KT, Sison JD, Quesenberry CP, Wrensch MR, Wiencke JK
• The landscape of recombination in African Americans.
  Nature 2011 Hinch AG, Tandon A, Patterson N, Song Y, Rohland N, Palmer CD, Chen GK, Wang K, Buxbaum SG, Akylbekova EL, Aldrich MC, Ambrosone CB, Amos C, Bandera EV, Berndt SI, Bernstein L, Blot WJ, Bock CH, …
• Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia.
  Cancer causes & control : CCC 2011 Metayer C, Scélo G, Chokkalingam AP, Barcellos LF, Aldrich MC, Chang JS, Guha N, Urayama KY, Hansen HM, Block G, Kiley V, Wiencke JK, Wiemels JL, Buffler PA
• Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking.
  American journal of epidemiology 2011 Lachance DH, Yang P, Johnson DR, Decker PA, Kollmeyer TM, McCoy LS, Rice T, Xiao Y, Ali-Osman F, Wang F, Stoddard SM, Sprau DJ, Kosel ML, Wiencke JK, Wiemels JL, Patoka JS, Davis F, McCarthy B, …
• The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood.
  Epigenetics 2011 Langevin SM, Houseman EA, Christensen BC, Wiencke JK, Nelson HH, Karagas MR, Marsit CJ, Kelsey KT
• DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression.
  Neuro-oncology 2011 Zheng S, Houseman EA, Morrison Z, Wrensch MR, Patoka JS, Ramos C, Haas-Kogan DA, McBride S, Marsit CJ, Christensen BC, Nelson HH, Stokoe D, Wiemels JL, Chang SM, Prados MD, Tihan T, Vandenberg SR, …
• Distinct germ line polymorphisms underlie glioma morphologic heterogeneity.
  Cancer genetics 2011 Jenkins RB, Wrensch MR, Johnson D, Fridley BL, Decker PA, Xiao Y, Kollmeyer TM, Rynearson AL, Fink S, Rice T, McCoy LS, Halder C, Kosel ML, Giannini C, Tihan T, O'Neill BP, Lachance DH, Yang P, …
• DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma.
  Journal of the National Cancer Institute 2010 Christensen BC, Smith AA, Zheng S, Koestler DC, Houseman EA, Marsit CJ, Wiemels JL, Nelson HH, Karagas MR, Wrensch MR, Kelsey KT, Wiencke JK
• TEL-AML1 regulation of survivin and apoptosis via miRNA-494 and miRNA-320a.
  Blood 2010 Diakos C, Zhong S, Xiao Y, Zhou M, Vasconcelos GM, Krapf G, Yeh RF, Zheng S, Kang M, Wiencke JK, Pombo-de-Oliveira MS, Panzer-Grümayer R, Wiemels JL
• DNA methylation profiles delineate etiologic heterogeneity and clinically important subgroups of bladder cancer.
  Carcinogenesis 2010 Wilhelm-Benartzi CS, Koestler DC, Houseman EA, Christensen BC, Wiencke JK, Schned AR, Karagas MR, Kelsey KT, Marsit CJ
• Identification of methylated genes associated with aggressive bladder cancer.
  PloS one 2010 Marsit CJ, Houseman EA, Christensen BC, Gagne L, Wrensch MR, Nelson HH, Wiemels J, Zheng S, Wiencke JK, Andrew AS, Schned AR, Karagas MR, Kelsey KT
• CD8+ T-cell infiltrate in newly diagnosed glioblastoma is associated with long-term survival.
  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2010 Yang I, Tihan T, Han SJ, Wrensch MR, Wiencke J, Sughrue ME, Parsa AT
• Circulating levels of the innate and humoral immune regulators CD14 and CD23 are associated with adult glioma.
  Cancer research 2010 Zhou M, Wiemels JL, Bracci PM, Wrensch MR, McCoy LS, Rice T, Sison JD, Patoka JS, Wiencke JK
• Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010 Chang JS, Wiemels JL, Chokkalingam AP, Metayer C, Barcellos LF, Hansen HM, Aldrich MC, Guha N, Urayama KY, Scélo G, Green J, May SL, Kiley VA, Wiencke JK, Buffler PA
• Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia.
  Blood cells, molecules & diseases 2010 Wiemels JL, Kang M, Chang JS, Zheng L, Kouyoumji C, Zhang L, Smith MT, Scelo G, Metayer C, Buffler P, Wiencke JK
• Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intake.
  PLoS genetics 2010 Christensen BC, Kelsey KT, Zheng S, Houseman EA, Marsit CJ, Wrensch MR, Wiemels JL, Nelson HH, Karagas MR, Kushi LH, Kwan ML, Wiencke JK
• Inherited variation in immune genes and pathways and glioblastoma risk.
  Carcinogenesis 2010 Schwartzbaum JA, Xiao Y, Liu Y, Tsavachidis S, Berger MS, Bondy ML, Chang JS, Chang SM, Decker PA, Ding B, Hepworth SJ, Houlston RS, Hosking FJ, Jenkins RB, Kosel ML, McCoy LS, McKinney PA, Muir K, …
• Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans.
  Human molecular genetics 2010 Hansen HM, Xiao Y, Rice T, Bracci PM, Wrensch MR, Sison JD, Chang JS, Smirnov IV, Patoka J, Seldin MF, Quesenberry CP, Kelsey KT, Wiencke JK
• Integrated profiling reveals a global correlation between epigenetic and genetic alterations in mesothelioma.
  Cancer research 2010 Christensen BC, Houseman EA, Poage GM, Godleski JJ, Bueno R, Sugarbaker DJ, Wiencke JK, Nelson HH, Marsit CJ, Kelsey KT
• Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium.
  Journal of the National Cancer Institute 2010 Truong T, Hung RJ, Amos CI, Wu X, Bickeböller H, Rosenberger A, Sauter W, Illig T, Wichmann HE, Risch A, Dienemann H, Kaaks R, Yang P, Jiang R, Wiencke JK, Wrensch M, Hansen H, Kelsey KT, Matsuo K, …
• Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010 Liu Y, Shete S, Etzel CJ, Scheurer M, Alexiou G, Armstrong G, Tsavachidis S, Liang FW, Gilbert M, Aldape K, Armstrong T, Houlston R, Hosking F, Robertson L, Xiao Y, Wiencke J, Wrensch M, Andersson U, …
• Genetic and epigenetic somatic alterations in head and neck squamous cell carcinomas are globally coordinated but not locally targeted.
  PloS one 2010 Poage GM, Christensen BC, Houseman EA, McClean MD, Wiencke JK, Posner MR, Clark JR, Nelson HH, Marsit CJ, Kelsey KT
• Chemokine polymorphisms and lymphoma: a pooled analysis.
  Leukemia & lymphoma 2010 Bracci PM, Skibola CF, Conde L, Halperin E, Lightfoot T, Smith A, Paynter RA, Skibola DR, Agana L, Roman E, Kane E, Wiencke JK
• KRAS mutation, KRAS-LCS6 polymorphism, and non-small cell lung cancer.
  Lung cancer (Amsterdam, Netherlands) 2009 Nelson HH, Christensen BC, Plaza SL, Wiencke JK, Marsit CJ, Kelsey KT
• Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival.
  Journal of neuro-oncology 2009 McBride SM, Perez DA, Polley MY, Vandenberg SR, Smith JS, Zheng S, Lamborn KR, Wiencke JK, Chang SM, Prados MD, Berger MS, Stokoe D, Haas-Kogan DA
• Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context.
  PLoS genetics 2009 Christensen BC, Houseman EA, Marsit CJ, Zheng S, Wrensch MR, Wiemels JL, Nelson HH, Karagas MR, Padbury JF, Bueno R, Sugarbaker DJ, Yeh RF, Wiencke JK, Kelsey KT
• IgE, allergy, and risk of glioma: update from the San Francisco Bay Area Adult Glioma Study in the temozolomide era.
  International journal of cancer 2009 Wiemels JL, Wilson D, Patil C, Patoka J, McCoy L, Rice T, Schwartzbaum J, Heimberger A, Sampson JH, Chang S, Prados M, Wiencke JK, Wrensch M
• Differentiation of lung adenocarcinoma, pleural mesothelioma, and nonmalignant pulmonary tissues using DNA methylation profiles.
  Cancer research 2009 Christensen BC, Marsit CJ, Houseman EA, Godleski JJ, Longacker JL, Zheng S, Yeh RF, Wrensch MR, Wiemels JL, Karagas MR, Bueno R, Sugarbaker DJ, Nelson HH, Wiencke JK, Kelsey KT
• Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.
  Nature genetics 2009 Wrensch M, Jenkins RB, Chang JS, Yeh RF, Xiao Y, Decker PA, Ballman KV, Berger M, Buckner JC, Chang S, Giannini C, Halder C, Kollmeyer TM, Kosel ML, LaChance DH, McCoy L, O'Neill BP, Patoka J, Pico AR…
• Copy number variation has little impact on bead-array-based measures of DNA methylation.
  Bioinformatics (Oxford, England) 2009 Houseman EA, Christensen BC, Karagas MR, Wrensch MR, Nelson HH, Wiemels JL, Zheng S, Wiencke JK, Kelsey KT, Marsit CJ
• Associations between polymorphisms in DNA repair genes and glioblastoma.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009 McKean-Cowdin R, Barnholtz-Sloan J, Inskip PD, Ruder AM, Butler M, Rajaraman P, Razavi P, Patoka J, Wiencke JK, Bondy ML, Wrensch M
• CYP1A1/2 haplotypes and lung cancer and assessment of confounding by population stratification.
  Cancer research 2009 Aldrich MC, Selvin S, Hansen HM, Barcellos LF, Wrensch MR, Sison JD, Kelsey KT, Buffler PA, Quesenberry CP, Seldin MF, Wiencke JK
• Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma.
  Carcinogenesis 2009 Marsit CJ, Christensen BC, Houseman EA, Karagas MR, Wrensch MR, Yeh RF, Nelson HH, Wiemels JL, Zheng S, Posner MR, McClean MD, Wiencke JK, Kelsey KT
• Epigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcome.
  Cancer research 2009 Christensen BC, Houseman EA, Godleski JJ, Marsit CJ, Longacker JL, Roelofs CR, Karagas MR, Wrensch MR, Yeh RF, Nelson HH, Wiemels JL, Zheng S, Wiencke JK, Bueno R, Sugarbaker DJ, Kelsey KT
• Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans.
  Carcinogenesis 2008 Chang JS, Wrensch MR, Hansen HM, Sison JD, Aldrich MC, Quesenberry CP, Seldin MF, Kelsey KT, Wiencke JK
• SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization system.
  Nucleic acids research 2008 Pico AR, Smirnov IV, Chang JS, Yeh RF, Wiemels JL, Wiencke JK, Tihan T, Conklin BR, Wrensch M
• International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008 Hung RJ, Christiani DC, Risch A, Popanda O, Haugen A, Zienolddiny S, Benhamou S, Bouchardy C, Lan Q, Spitz MR, Wichmann HE, LeMarchand L, Vineis P, Matullo G, Kiyohara C, Zhang ZF, Pezeshki B, Harris …
• Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans.
  International journal of cancer 2008 Chang JS, Wrensch MR, Hansen HM, Sison JD, Aldrich MC, Quesenberry CP, Seldin MF, Kelsey KT, Kittles RA, Silva G, Wiencke JK
• Comparison of statistical methods for estimating genetic admixture in a lung cancer study of African Americans and Latinos.
  American journal of epidemiology 2008 Aldrich MC, Selvin S, Hansen HM, Barcellos LF, Wrensch MR, Sison JD, Quesenberry CP, Kittles RA, Silva G, Buffler PA, Seldin MF, Wiencke JK
• Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions.
  BMC bioinformatics 2008 Houseman EA, Christensen BC, Yeh RF, Marsit CJ, Karagas MR, Wrensch M, Nelson HH, Wiemels J, Zheng S, Wiencke JK, Kelsey KT
• Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forests.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008 Chang JS, Yeh RF, Wiencke JK, Wiemels JL, Smirnov I, Pico AR, Tihan T, Patoka J, Miike R, Sison JD, Rice T, Wrensch MR
• The Pathways Study: a prospective study of breast cancer survivorship within Kaiser Permanente Northern California.
  Cancer causes & control : CCC 2008 Kwan ML, Ambrosone CB, Lee MM, Barlow J, Krathwohl SE, Ergas IJ, Ashley CH, Bittner JR, Darbinian J, Stronach K, Caan BJ, Davis W, Kutner SE, Quesenberry CP, Somkin CP, Sternfeld B, Wiencke JK, Zheng …
• Differentially expressed genes are marked by histone 3 lysine 9 trimethylation in human cancer cells.
  Oncogene 2007 Wiencke JK, Zheng S, Morrison Z, Yeh RF
• DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomas.
  Neuroepidemiology 2007 Felini MJ, Olshan AF, Schroeder JC, North KE, Carozza SE, Kelsey KT, Liu M, Rice T, Wiencke JK, Wrensch MR
• DNA quantification of whole genome amplified samples for genotyping on a multiplexed bead array platform.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007 Hansen HM, Wiemels JL, Wrensch M, Wiencke JK
• Allergy-related polymorphisms influence glioma status and serum IgE levels.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007 Wiemels JL, Wiencke JK, Kelsey KT, Moghadassi M, Rice T, Urayama KY, Miike R, Wrensch M
• MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007 Urayama KY, Wiencke JK, Buffler PA, Chokkalingam AP, Metayer C, Wiemels JL
• Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma.
  Neuro-oncology 2007 Wiencke JK, Zheng S, Jelluma N, Tihan T, Vandenberg S, Tamgüney T, Baumber R, Parsons R, Lamborn KR, Berger MS, Wrensch MR, Haas-Kogan DA, Stokoe D
• DNA adducts in granulocytes of hospital workers exposed to ethylene oxide.
  American journal of industrial medicine 2007 Yong LC, Schulte PA, Kao CY, Giese RW, Boeniger MF, Strauss GH, Petersen MR, Wiencke JK
• Lower specific micronutrient intake in colorectal cancer patients with tumors presenting promoter hypermethylation in p16(INK4a), p4(ARF) and hMLH1.
  Anticancer research 2007 Mas S, Lafuente MJ, Crescenti A, Trias M, Ballesta A, Molina R, Zheng S, Wiencke JK, Lafuente A
• Genetic polymorphisms in MTHFR 677 and 1298, GSTM1 and T1, and metabolism of arsenic.
  Journal of toxicology and environmental health. Part A 2007 Steinmaus C, Moore LE, Shipp M, Kalman D, Rey OA, Biggs ML, Hopenhayn C, Bates MN, Zheng S, Wiencke JK, Smith AH
• Nonsynonymous coding single-nucleotide polymorphisms spanning the genome in relation to glioblastoma survival and age at diagnosis.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Wrensch M, McMillan A, Wiencke J, Wiemels J, Kelsey K, Patoka J, Jones H, Carlton V, Miike R, Sison J, Moghadassi M, Prados M
• DNA adducts among asphalt paving workers.
  The Annals of occupational hygiene 2006 McClean MD, Wiencke JK, Kelsey KT, Varkonyi A, Ngo L, Eisen EA, Herrick RF
• Serum IgE, tumor epidermal growth factor receptor expression, and inherited polymorphisms associated with glioma survival.
  Cancer research 2006 Wrensch M, Wiencke JK, Wiemels J, Miike R, Patoka J, Moghadassi M, McMillan A, Kelsey KT, Aldape K, Lamborn KR, Parsa AT, Sison JD, Prados MD
• Homozygous deletion of p16INK4a and tobacco carcinogen exposure in nonsmall cell lung cancer.
  International journal of cancer 2006 Kraunz KS, Nelson HH, Lemos M, Godleski JJ, Wiencke JK, Kelsey KT
• The case for strategic international alliances to harness nutritional genomics for public and personal health.
  The British journal of nutrition 2005 Kaput J, Ordovas JM, Ferguson L, van Ommen B, Rodriguez RL, Allen L, Ames BN, Dawson K, German B, Krauss R, Malyj W, Archer MC, Barnes S, Bartholomew A, Birk R, van Bladeren P, Bradford KJ, Brown KH, …
• Interaction between the bone morphogenetic proteins and Ras/MAP-kinase signalling pathways in lung cancer.
  British journal of cancer 2005 Kraunz KS, Nelson HH, Liu M, Wiencke JK, Kelsey KT
• Alterations of 9p in squamous cell carcinoma and adenocarcinoma of the lung: association with smoking, TP53, and survival.
  Cancer genetics and cytogenetics 2005 Marsit CJ, Wiencke JK, Nelson HH, Kim DH, Hinds PW, Aldape K, Kelsey KT
• ERCC1 and ERCC2 polymorphisms and adult glioma.
  Neuro-oncology 2005 Wrensch M, Kelsey KT, Liu M, Miike R, Moghadassi M, Sison JD, Aldape K, McMillan A, Wiemels J, Wiencke JK
• Molecular biomarkers for the study of childhood leukemia.
  Toxicology and applied pharmacology 2005 Smith MT, McHale CM, Wiemels JL, Zhang L, Wiencke JK, Zheng S, Gunn L, Skibola CF, Ma X, Buffler PA
• Ethnic difference in daycare attendance, early infections, and risk of childhood acute lymphoblastic leukemia.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005 Ma X, Buffler PA, Wiemels JL, Selvin S, Metayer C, Loh M, Does MB, Wiencke JK
• Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiforme.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005 Tang J, Shao W, Dorak MT, Li Y, Miike R, Lobashevsky E, Wiencke JK, Wrensch M, Kaslow RA, Cobbs CS
• Molecular features of adult glioma associated with patient race/ethnicity, age, and a polymorphism in O6-methylguanine-DNA-methyltransferase.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005 Wiencke JK, Aldape K, McMillan A, Wiemels J, Moghadassi M, Miike R, Kelsey KT, Patoka J, Long J, Wrensch M
• PTEN expression in non-small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration.
  Human pathology 2005 Marsit CJ, Zheng S, Aldape K, Hinds PW, Nelson HH, Wiencke JK, Kelsey KT
• Polyphenol associated-DNA adducts in lung and blood mononuclear cells from lung cancer patients.
  Cancer letters 2005 Várkonyi A, Kelsey K, Semey K, Bodell WJ, Lévay G, Mark E, Wain JC, Christiani DC, Wiencke JK
• The C3435T polymorphism of MDR1 and susceptibility to adult glioma.
  Neuroepidemiology 2005 Miller KL, Kelsey KT, Wiencke JK, Moghadassi M, Miike R, Liu M, Wrensch M
• History of chickenpox and shingles and prevalence of antibodies to varicella-zoster virus and three other herpesviruses among adults with glioma and controls.
  American journal of epidemiology 2005 Wrensch M, Weinberg A, Wiencke J, Miike R, Sison J, Wiemels J, Barger G, DeLorenze G, Aldape K, Kelsey K
• The race associated allele of Semaphorin 3B (SEMA3B) T415I and its role in lung cancer in African-Americans and Latino-Americans.
  Carcinogenesis 2005 Marsit CJ, Wiencke JK, Liu M, Kelsey KT
• Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescence.
  International journal of cancer 2005 Marsit CJ, Kim DH, Liu M, Hinds PW, Wiencke JK, Nelson HH, Kelsey KT
• RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia.
  Leukemia 2005 Wiemels JL, Zhang Y, Chang J, Zheng S, Metayer C, Zhang L, Smith MT, Ma X, Selvin S, Buffler PA, Wiencke JK
• CYP1A1 variants and smoking-related lung cancer in San Francisco Bay area Latinos and African Americans.
  International journal of cancer 2005 Wrensch MR, Miike R, Sison JD, Kelsey KT, Liu M, McMillan A, Quesenberry C, Wiencke JK
• Loss of heterozygosity of chromosome 3p21 is associated with mutant TP53 and better patient survival in non-small-cell lung cancer.
  Cancer research 2004 Marsit CJ, Hasegawa M, Hirao T, Kim DH, Aldape K, Hinds PW, Wiencke JK, Nelson HH, Kelsey KT
• Reduced immunoglobulin E and allergy among adults with glioma compared with controls.
  Cancer research 2004 Wiemels JL, Wiencke JK, Patoka J, Moghadassi M, Chew T, McMillan A, Miike R, Barger G, Wrensch M
• Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina.
  Cancer letters 2004 Moore LE, Wiencke JK, Bates MN, Zheng S, Rey OA, Smith AH
• Urinary 1-hydroxypyrene and polycyclic aromatic hydrocarbon exposure among asphalt paving workers.
  The Annals of occupational hygiene 2004 McClean MD, Rinehart RD, Ngo L, Eisen EA, Kelsey KT, Wiencke JK, Herrick RF
• On the use of biomarkers for environmental health research.
  Statistical methods in medical research 2004 Ryan L, Huang W, Thurston SW, Kelsey KT, Wiencke JK, Christiani DC
• Decrease in specific micronutrient intake in colorectal cancer patients with tumors presenting Ki-ras mutation.
  Anticancer research 2004 Laso N, Mas S, Jose Lafuente M, Casterad X, Trias M, Ballesta A, Molina R, Salas J, Ascaso C, Zheng S, Wiencke JK, Lafuente A
• Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia.
  Cancer research 2004 Zheng S, Ma X, Zhang L, Gunn L, Smith MT, Wiemels JL, Leung K, Buffler PA, Wiencke JK
• Lack of increased genetic damage in 1,3-butadiene-exposed Chinese workers studied in relation to EPHX1 and GST genotypes.
  Mutation research 2004 Zhang L, Hayes RB, Guo W, McHale CM, Yin S, Wiencke JK, Patrick O'Neill J, Rothman N, Li GL, Smith MT
• Glutathione-S-transferase variants and adult glioma.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004 Wrensch M, Kelsey KT, Liu M, Miike R, Moghadassi M, Aldape K, McMillan A, Wiencke JK
• Impact of race/ethnicity on molecular pathways in human cancer.
  Nature reviews. Cancer 2004 Wiencke JK
• Population- and community-based recruitment of African Americans and Latinos: the San Francisco Bay Area Lung Cancer Study.
  American journal of epidemiology 2003 Cabral DN, Nápoles-Springer AM, Miike R, McMillan A, Sison JD, Wrensch MR, Pérez-Stable EJ, Wiencke JK, San Francisco Bay Area Lung Cancer Study
• Cancer, genes, and catechol estrogen metabolites.
  International journal of clinical oncology 2003 Mas S, Laso N, Lafuente MJ, Lafuente A, Molina R, Ballesta A, Zheng S, Wiencke JK
• DNA adduct burden and tobacco carcinogenesis.
  Oncogene 2002 Wiencke JK
• In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia.
  Blood 2002 Wiemels JL, Xiao Z, Buffler PA, Maia AT, Ma X, Dicks BM, Smith MT, Zhang L, Feusner J, Wiencke J, Pritchard-Jones K, Kempski H, Greaves M
• Daycare attendance and risk of childhood acute lymphoblastic leukaemia.
  British journal of cancer 2002 Ma X, Buffler PA, Selvin S, Matthay KK, Wiencke JK, Wiemels JL, Reynolds P
• History of allergies among adults with glioma and controls.
  International journal of cancer 2002 Wiemels JL, Wiencke JK, Sison JD, Miike R, McMillan A, Wrensch M
• A population-based, case-control study of polymorphisms in carcinogen-metabolizing genes, smoking, and pancreatic adenocarcinoma risk.
  Journal of the National Cancer Institute 2002 Duell EJ, Holly EA, Bracci PM, Liu M, Wiencke JK, Kelsey KT
• Molecular characterization of genomic AML1-ETO fusions in childhood leukemia.
  Leukemia 2001 Xiao Z, Greaves MF, Buffler P, Smith MT, Segal MR, Dicks BM, Wiencke JK, Wiemels JL
• Prevalence of antibodies to four herpesviruses among adults with glioma and controls.
  American journal of epidemiology 2001 Wrensch M, Weinberg A, Wiencke J, Miike R, Barger G, Kelsey K
• Markers for carcinogenicity among butadiene-polymer workers in China.
  Chemico-biological interactions 2001 Hayes RB, Zhang L, Swenberg JA, Yin SN, Xi L, Wiencke J, Bechtold WE, Yao M, Rothman N, Haas R, O'Neill JP, Wiemels J, Dosemeci M, Li G, Smith MT
• Ethnicity delineates different genetic pathways in malignant glioma.
  Cancer research 2001 Chen P, Aldape K, Wiencke JK, Kelsey KT, Miike R, Davis RL, Liu J, Kesler-Diaz A, Takahashi M, Wrensch M
• Hemoglobin adducts and sister chromatid exchanges in hospital workers exposed to ethylene oxide: effects of glutathione S-transferase T1 and M1 genotypes.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001 Yong LC, Schulte PA, Wiencke JK, Boeniger MF, Connally LB, Walker JT, Whelan EA, Ward EM
• p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer.
  Cancer research 2001 Kim DH, Nelson HH, Wiencke JK, Zheng S, Christiani DC, Wain JC, Mark EJ, Kelsey KT
• Associations between ERCC2 polymorphisms and gliomas.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001 Caggana M, Kilgallen J, Conroy JM, Wiencke JK, Kelsey KT, Miike R, Chen P, Wrensch MR
• Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer.
  Oncogene 2001 Kim DH, Nelson HH, Wiencke JK, Christiani DC, Wain JC, Mark EJ, Kelsey KT
• Evaluation of buccal cell collection protocols for genetic susceptibility studies.
  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2001 Moore L, Wiencke J, Eng C, Zheng S, Smith A
• Correlations of partial and extensive methylation at the p14(ARF) locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumors.
  Carcinogenesis 2000 Zheng S, Chen P, McMillan A, Lafuente A, Lafuente MJ, Ballesta A, Trias M, Wiencke JK
• NAD(P)H:quinone oxidoreductase-dependent risk for colorectal cancer and its association with the presence of K-ras mutations in tumors.
  Carcinogenesis 2000 Lafuente MJ, Casterad X, Trias M, Ascaso C, Molina R, Ballesta A, Zheng S, Wiencke JK, Lafuente A
• The p53 codon 72 polymorphism and lung cancer risk.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2000 Fan R, Wu MT, Miller D, Wain JC, Kelsey KT, Wiencke JK, Christiani DC
• Association of an ERCC1 polymorphism with adult-onset glioma.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2000 Chen P, Wiencke J, Aldape K, Kesler-Diaz A, Miike R, Kelsey K, Lee M, Liu J, Wrensch M
• Chromosomal aberrations and hprt mutant frequencies in long-term American thorotrast survivors.
  International journal of radiation biology 2000 Platz EA, Wiencke JK, Kelsey KT, Janower ML, Schottenfeld D, Travis LB, Goldman MB
• Discrepancies in diagnoses of neuroepithelial neoplasms: the San Francisco Bay Area Adult Glioma Study.
  Cancer 2000 Aldape K, Simmons ML, Davis RL, Miike R, Wiencke J, Barger G, Lee M, Chen P, Wrensch M
• Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells.
  Carcinogenesis 2000 Duell EJ, Wiencke JK, Cheng TJ, Varkonyi A, Zuo ZF, Ashok TD, Mark EJ, Wain JC, Christiani DC, Kelsey KT
• Lack of association of rare alleles in the HRAS variable number of tandem repeats (VNTR) region with adult glioma.
  Neuro-oncology 2000 Chen P, Wiencke JK, Conway K, Edmiston SN, Miike R, Wrensch M
• Negative binomial additive models.
  Biometrics 2000 Thurston SW, Wand MP, Wiencke JK
• Genotoxic markers among butadiene polymer workers in China.
  Carcinogenesis 2000 Hayes RB, Zhang L, Yin S, Swenberg JA, Xi L, Wiencke J, Bechtold WE, Yao M, Rothman N, Haas R, O'Neill JP, Zhang D, Wiemels J, Dosemeci M, Li G, Smith MT
• Implications and prognostic value of K-ras mutation for early-stage lung cancer in women.
  Journal of the National Cancer Institute 1999 Nelson HH, Christiani DC, Mark EJ, Wiencke JK, Wain JC, Kelsey KT
• k-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis.
  Cancer research 1999 Nelson HH, Christiani DC, Wiencke JK, Mark EJ, Wain JC, Kelsey KT
• Aberrant methylation of p16INK4a in anatomic and gender-specific subtypes of sporadic colorectal cancer.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1999 Wiencke JK, Zheng S, Lafuente A, Lafuente MJ, Grudzen C, Wrensch MR, Miike R, Ballesta A, Trias M
• Modulation of the toxicity and macromolecular binding of benzene metabolites by NAD(P)H:Quinone oxidoreductase in transfected HL-60 cells.
  Chemical research in toxicology 1999 Wiemels J, Wiencke JK, Varykoni A, Smith MT
• Carcinogen exposure, p53 alteration, and K-ras mutation in synchronous multiple primary lung carcinoma.
  Cancer 1999 Wang X, Christiani DC, Mark EJ, Nelson H, Wiencke JK, Gunn L, Wain JC, Kelsey KT
• Early age at smoking initiation and tobacco carcinogen DNA damage in the lung.
  Journal of the National Cancer Institute 1999 Wiencke JK, Thurston SW, Kelsey KT, Varkonyi A, Wain JC, Mark EJ, Christiani DC
• Association between diet and lung cancer location.
  American journal of respiratory and critical care medicine 1998 Lee BW, Wain JC, Kelsey KT, Wiencke JK, Christiani DC
• Chromosome 3p14 alterations in lung cancer: evidence that FHIT exon deletion is a target of tobacco carcinogens and asbestos.
  Cancer research 1998 Nelson HH, Wiencke JK, Gunn L, Wain JC, Christiani DC, Kelsey KT
• Growing pains for the environmental genetics of breast cancer: observations on a study of the glutathione S-transferases.
  Journal of the National Cancer Institute 1998 Kelsey KT, Wiencke JK
• Association of cigarette smoking and asbestos exposure with location and histology of lung cancer.
  American journal of respiratory and critical care medicine 1998 Lee BW, Wain JC, Kelsey KT, Wiencke JK, Christiani DC
• Benzene exposure, glutathione S-transferase theta homozygous deletion, and sister chromatid exchanges.
  American journal of industrial medicine 1998 Xu X, Wiencke JK, Niu T, Wang M, Watanabe H, Kelsey KT, Christiani DC
• Polymorphisms in the N acetyltransferase 1 NAT1 gene and lung cancer risk in a minority population.
  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 1998 Ishibe N, Wiencke JK, Zuo ZF, McMillan A, Spitz MR, Kelsey KT
• A population-based case-control study of the CYP2D6 and GSTT1 polymorphisms and malignant brain tumors.
  Pharmacogenetics 1997 Kelsey KT, Wrensch M, Zuo ZF, Miike R, Wiencke JK
• Susceptibility to lung cancer in light smokers associated with CYP1A1 polymorphisms in Mexican- and African-Americans.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1997 Ishibe N, Wiencke JK, Zuo ZF, McMillan A, Spitz M, Kelsey KT
• A case-control study of cytochrome P450 1A1, glutathione S-transferase M1, cigarette smoking and lung cancer susceptibility (Massachusetts, United States)
  Cancer causes & control : CCC 1997 Garcia-Closas M, Kelsey KT, Wiencke JK, Xu X, Wain JC, Christiani DC
• Polymorphisms in the glutathione S-transferase class mu and theta genes interact and increase susceptibility to lung cancer in minority populations (Texas, United States).
  Cancer causes & control : CCC 1997 Kelsey KT, Spitz MR, Zuo ZF, Wiencke JK
• Population-based study of glutathione S-transferase mu gene deletion in adult glioma cases and controls.
  Carcinogenesis 1997 Wiencke JK, Wrensch MR, Miike R, Zuo Z, Kelsey KT
• Inhibition of poly(ADP-ribose) polymerase by arsenite.
  Mutation research 1997 Yager JW, Wiencke JK
• Study of arsenic mutagenesis using the plasmid shuttle vector pZ189 propagated in DNA repair proficient human cells.
  Mutation research 1997 Wiencke JK, Yager JW, Varkonyi A, Hultner M, Lutze LH
• Does prior infection with varicella-zoster virus influence risk of adult glioma?
  American journal of epidemiology 1997 Wrensch M, Weinberg A, Wiencke J, Masters H, Miike R, Barger G, Lee M
• Familial and personal medical history of cancer and nervous system conditions among adults with glioma and controls.
  American journal of epidemiology 1997 Wrensch M, Lee M, Miike R, Newman B, Barger G, Davis R, Wiencke J, Neuhaus J
• The glutathione S-transferase theta and mu deletion polymorphisms in asbestosis.
  American journal of industrial medicine 1997 Kelsey KT, Nelson HH, Wiencke JK, Smith CM, Levin S
• Lung cancer in Mexican-Americans and African-Americans is associated with the wild-type genotype of the NAD(P)H: quinone oxidoreductase polymorphism.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1997 Wiencke JK, Spitz MR, McMillan A, Kelsey KT
• Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy.
  British journal of cancer 1997 Kelsey KT, Ross D, Traver RD, Christiani DC, Zuo ZF, Spitz MR, Wang M, Xu X, Lee BK, Schwartz BS, Wiencke JK
• Stimulatory influence of soy protein isolate on breast secretion in pre- and postmenopausal women.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1996 Petrakis NL, Barnes S, King EB, Lowenstein J, Wiencke J, Lee MM, Miike R, Kirk M, Coward L
• Cytochrome P450 CYP1A1 MspI polymorphism and lung cancer susceptibility.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1996 Xu X, Kelsey KT, Wiencke JK, Wain JC, Christiani DC
• Increased micronucleus frequency in lymphocytes from smokers with lung cancer.
  Mutation research 1996 Cheng TJ, Christiani DC, Xu X, Wain JC, Wiencke JK, Kelsey KT
• Sister-chromatid exchanges, glutathione S-transferase theta deletion and cytogenetic sensitivity to diepoxybutane in lymphocytes from butadiene monomer production workers.
  Mutation research 1995 Kelsey KT, Wiencke JK, Ward J, Bechtold W, Fajen J
• Correlation of DNA adducts in blood mononuclear cells with tobacco carcinogen-induced damage in human lung.
  Cancer research 1995 Wiencke JK, Kelsey KT, Varkonyi A, Semey K, Wain JC, Mark E, Christiani DC
• Mutant frequency at the hprt locus in human lymphocytes in a case-control study of lung cancer.
  Mutation research 1995 Cheng TJ, Christiani DC, Liber HL, Wain JC, Xu X, Wiencke JK, Kelsey KT
• Comparison of sister chromatid exchange frequency in peripheral lymphocytes in lung cancer cases and controls.
  Mutation research 1995 Cheng TJ, Christiani DC, Wiencke JK, Wain JC, Xu X, Kelsey KT
• Glutathione S-transferase mu genotype, diet, and smoking as determinants of sister chromatid exchange frequency in lymphocytes.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1995 Cheng TJ, Christiani DC, Xu X, Wain JC, Wiencke JK, Kelsey KT
• Mutations in the p53 gene in lung cancer are associated with cigarette smoking and asbestos exposure.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1995 Wang X, Christiani DC, Wiencke JK, Fischbein M, Xu X, Cheng TJ, Mark E, Wain JC, Kelsey KT
• Genotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
  Mutation research 1995 Wiencke JK, Wiemels J
• Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta.
  Carcinogenesis 1995 Nelson HH, Wiencke JK, Christiani DC, Cheng TJ, Zuo ZF, Schwartz BS, Lee BK, Spitz MR, Wang M, Xu X
• Gene deletion of glutathione S-transferase theta: correlation with induced genetic damage and potential role in endogenous mutagenesis.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1995 Wiencke JK, Pemble S, Ketterer B, Kelsey KT
• Inherited glutathione-S-transferase deficiency is a risk factor for pulmonary asbestosis.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1994 Smith CM, Kelsey KT, Wiencke JK, Leyden K, Levin S, Christiani DC
• A race-specific genetic polymorphism in the CYP1A1 gene is not associated with lung cancer in African Americans.
  Carcinogenesis 1994 Kelsey KT, Wiencke JK, Spitz MR
• Genetics of primary brain tumors: a review.
  Journal of neuro-oncology 1994 Bondy M, Wiencke J, Wrensch M, Kyritsis AP
• Gross cystic disease fluid protein in nipple aspirates of breast fluid of Asian and non-Asian women.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1993 Petrakis NL, Lowenstein JM, Wiencke JK, Lee MM, Wrensch MR, King EB, Hilton JF, Miike R
• Enhancement of chromosomal damage by arsenic: implications for mechanism.
  Environmental health perspectives 1993 Yager JW, Wiencke JK
• Indications of repair of radon-induced chromosome damage in human lymphocytes: an adaptive response induced by low doses of X-rays.
  Environmental health perspectives 1993 Wolff S, Afzal V, Jostes RF, Wiencke JK
• Environmental risk factors for primary malignant brain tumors: a review.
  Journal of neuro-oncology 1993 Wrensch M, Bondy ML, Wiencke J, Yost M
• Glutathione S-transferase mu polymorphism does not explain variation in nitroglycerin responsiveness.
  Clinical pharmacology and therapeutics 1993 Haefeli WE, Srivastava N, Kelsey KT, Wiencke JK, Hoffman BB, Blaschke TF
• Susceptibility to induction of chromosomal damage by metabolites of 1,3-butadiene and its relationship to 'spontaneous' sister chromatid exchange frequencies in human lymphocytes.
  IARC scientific publications 1993 Wiencke JK, Kelsey KT
• Heterogeneity in the clastogenic response to X-rays in lymphocytes from ataxia-telangiectasia heterozygotes and controls.
  Cancer causes & control : CCC 1992 Wiencke JK, Wara DW, Little JB, Kelsey KT
• Specificity of arsenite in potentiating cytogenetic damage induced by the DNA crosslinking agent diepoxybutane.
  Environmental and molecular mutagenesis 1992 Wiencke JK, Yager JW
• Individual susceptibility to induced chromosome damage and its implications for detecting genotoxic exposures in human populations.
  Cancer research 1991 Wiencke JK, Wrensch MR, Miike R, Petrakis NL
• Adaptive response of human lymphocytes for the repair of radon-induced chromosomal damage.
  Mutation research 1991 Wolff S, Jostes R, Cross FT, Hui TE, Afzal V, Wiencke JK
• Bimodal distribution of sensitivity to SCE induction by diepoxybutane in human lymphocytes. I. Correlation with chromosomal aberrations.
  Mutation research 1991 Wiencke JK, Christiani DC, Kelsey KT
• Bimodal distribution of sensitivity to SCE induction by diepoxybutane in human lymphocytes. II. Relationship to baseline SCE frequency.
  Mutation research 1991 Kelsey KT, Christiani DC, Wiencke JK
• Molecular dosimetry of DNA adducts and sister chromatid exchanges in human lymphocytes treated with benzo[a]pyrene.
  Carcinogenesis 1990 Wiencke JK, McDowell ML, Bodell WJ
• Human glutathione S-transferase deficiency as a marker of susceptibility to epoxide-induced cytogenetic damage.
  Cancer research 1990 Wiencke JK, Kelsey KT, Lamela RA, Toscano WA
• Genetic polymorphisms in carcinogen metabolism predict substrate-induced cytogenetic damage in humans.
  Progress in clinical and biological research 1990 Wiencke JK, Kelsey KT, Lamela RA, Toscano WA
• Inhibition of the adaptive response of human lymphocytes to very low doses of ionizing radiation by the protein synthesis inhibitor cycloheximide.
  Mutation research 1989 Youngblom JH, Wiencke JK, Wolff S
• Sister chromatid exchange in painters recently exposed to solvents.
  Environmental research 1989 Kelsey KT, Wiencke JK, Little FF, Baker EL, Little JB
• Antipain-mediated suppression of X-ray-induced chromosomal aberrations in human lymphocytes.
  Carcinogenesis 1989 Afzal V, Wiencke JK, Wolff S
• Induction of the adaptive response by X-rays is dependent on radiation intensity.
  International journal of radiation biology 1989 Shadley JD, Wiencke JK
• Sister chromatid exchange in chronic ethylene oxide-exposed primates: unexpected effects of in vitro culture duration, incubation temperature, and serum supplementation.
  Cancer research 1989 Kelsey KT, Wiencke JK, Eisen EA, Lynch DW, Lewis TR, Little JB
• Chromosomal aberrations and sister-chromatid exchanges in tool and die workers.
  Mutation research 1989 Garry VF, Nelson RL, Whorton EP, Wiencke JK
• Persistently elevated sister chromatid exchanges in ethylene oxide-exposed primates: the role of a subpopulation of high frequency cells.
  Cancer research 1988 Kelsey KT, Wiencke JK, Eisen EA, Lynch DW, Lewis TR, Little JB
• Effects of cigarette smoking and solvent exposure on sister chromatid exchange frequency in painters.
  Environmental and molecular mutagenesis 1988 Kelsey KT, Wiencke JK, Little FF, Baker EL, Little JB
• Human lymphocytes exposed to low doses of ionizing radiations become refractory to high doses of radiation as well as to chemical mutagens that induce double-strand breaks in DNA.
  International journal of radiation biology and related studies in physics, chemistry, and medicine 1988 Wolff S, Afzal V, Wiencke JK, Olivieri G, Michaeli A
• Nicotinamide deficiency in human lymphocytes prevents the [3H]thymidine-induced adaptive response for the repair of X-ray-induced chromosomal damage.
  Experimental cell research 1987 Wiencke JK
• Cell cycle-dependent potentiation of X-ray-induced chromosomal aberrations by 3-aminobenzamide.
  Biochemical and biophysical research communications 1987 Wiencke JK, Morgan WF
• Evidence that the [3H]thymidine-induced adaptive response of human lymphocytes to subsequent doses of X-rays involves the induction of a chromosomal repair mechanism.
  Mutagenesis 1986 Wiencke JK, Afzal V, Olivieri G, Wolff S
• 3-Aminobenzamide does not affect X-ray-induced cytogenetic damage in G0 human lymphocytes.
  Mutation research 1986 Pantelias GE, Politis G, Sabani CD, Wiencke JK, Morgan WF
• N-Methyl-N-nitrosourea potentiation of cytogenetic damage induced by 1,3-bis(2-chloroethyl)-1-nitrosourea in normal human lymphocytes.
  Cancer research 1985 Wiencke JK, Bodell WJ
• Ethylene oxide and some factors affecting the mutagen sensitivity of sister chromatid exchange in humans.
  Basic life sciences 1984 Garry VF, Wiencke JK, Nelson RL
• Serum- and plasma-dependent variations of benzo(a)pyrene-induced sister chromatid exchange in human lymphocytes.
  Basic life sciences 1984 Wiencke JK, Kelsey K, Kreiger R, Garry VF
• Sister-chromatid exchange induction by cis-platinum/adriamycin cancer chemotherapy.
  Mutation research 1982 Wiencke JK, Cervenka J, Kennedy BJ, Prlina J, Gorlin R
• Differential induction of sister chromatid exchange by chemical carcinogens in lymphocytes cultured from patients with solid tumors.
  Pharmacology 1982 Wiencke JK, Vosika J, Johnson P, Wang N, Garry VF
• Ethylene oxide induced sister chromatid exchange in human lymphocytes using a membrane dosimetry system.
  Pharmacology 1982 Garry VF, Opp CW, Wiencke JK, Lakatua D
• Mutagenic activity of anticancer agent cis-dichlorodiammine platinum-II.
  Mutation research 1979 Wiencke JK, Cervenka J, Paulus H