John Rubenstein, MD, PhD
Professor
Psychiatry
School of Medicine

415-476-7872

Awards

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W. Maxwell Cowan Award for Developmental Neuroscience, J. Comparative Neurology, 2021
National Academy of Sciences, 2020
Ted Jones Neuroscience Lecture, UC Davis, 2018
National American Academy of Arts and Sciences, 2016
Ittleson Award for Research in Child and Adolescent Psychiatry, American Psychiatric Association, 2016
Ruane Prize for Outstanding Child and Adolescent Psychiatric Research, Brain & Behavior Research Foundation, 2016
Distinguished Scientist Award, Child Mind Institute, 2015
Heinrich Waelsch Memorial Neuroscience Lecturer, Columbia School of Medicine, 2015
Pinckney J. Harman Memorial Award in Cortical Development, Cajal Club, 2014
Faculty Lecturer Basic Science, UCSF, 2013
Royer Award for Excellence in Academic Psychiatry, UCSF, 2012
Cajal Club President, Cajal Club, 2008
National Academy of Medicine, 2006
Krieg Cortical Discoverer Award, Cajal Club, 2004
Phi Beta Kappa, Stanford University, 1997
Presidential Scholar Award for Research, AACAP, 1991
Honor in Chemistry, Stanford University, 1977

Education & Training

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Residency Psychiatry Stanford 1991
Postdoc Mouse Embryology Pasteur Institute 1986
MD Stanford 1986
Biophysics Membrane Structure and Biogenesis Stanford 1982
BS Chemistry Stanford 1977

Grants and Projects

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Publications (340)

Top publication keywords:
NeocortexHomeodomain ProteinsBody PatterningInterneuronsTranscription FactorsNerve Tissue ProteinsLIM-Homeodomain ProteinsProsencephalonGenes, HomeoboxGABAergic NeuronsEnhancer Elements, GeneticCerebral CortexFibroblast Growth FactorsTelencephalonGene Expression Regulation, Developmental

Erratum.
The Journal of comparative neurology 2024 Rubenstein JLR
Tsc1 Loss in VIP-Lineage Cortical Interneurons Results in More VIP+ Interneurons and Enhanced Excitability.
Cells 2023 Hu JS, Malik R, Sohal VS, Rubenstein JL, Vogt D
Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy.
Cell stem cell 2023 Bershteyn M, Bröer S, Parekh M, Maury Y, Havlicek S, Kriks S, Fuentealba L, Lee S, Zhou R, Subramanyam G, Sezan M, Sevilla ES, Blankenberger W, Spatazza J, Zhou L, Nethercott H, Traver D, Hampel P, …
Critical test of the assumption that the hypothalamic entopeduncular nucleus of rodents is homologous with the primate internal pallidum.
The Journal of comparative neurology 2023 Puelles L, Stühmer T, Rubenstein JLR, Diaz C
The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus.
Developmental biology 2023 Biswas S, Chan CS, Rubenstein JLR, Gan L

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Combinatorial transcription factor binding encodes cis-regulatory wiring of forebrain GABAergic neurogenesis.
bioRxiv : the preprint server for biology 2023 Catta-Preta R, Lindtner S, Ypsilanti A, Price J, Abnousi A, Su-Feher L, Wang Y, Juric I, Jones IR, Akiyama JA, Hu M, Shen Y, Visel A, Pennacchio LA, Dickel D, Rubenstein JLR, Nord AS
Machine learning dissection of human accelerated regions in primate neurodevelopment.
Neuron 2023 Whalen S, Inoue F, Ryu H, Fair T, Markenscoff-Papadimitriou E, Keough K, Kircher M, Martin B, Alvarado B, Elor O, Laboy Cintron D, Williams A, Hassan Samee MA, Thomas S, Krencik R, Ullian EM, …
Dorsoventral Arrangement of Lateral Hypothalamus Populations in the Mouse Hypothalamus: a Prosomeric Genoarchitectonic Analysis.
Molecular neurobiology 2022 Diaz C, de la Torre MM, Rubenstein JLR, Puelles L
DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression.
Development (Cambridge, England) 2022 Price JD, Lindtner S, Ypsilanti A, Binyameen F, Johnson JR, Newton BW, Krogan NJ, Rubenstein JLR
Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin.
Nature neuroscience 2022 Tsai NY, Wang F, Toma K, Yin C, Takatoh J, Pai EL, Wu K, Matcham AC, Yin L, Dang EJ, Marciano DK, Rubenstein JL, Wang F, Ullian EM, Duan X
Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia.
Proceedings of the National Academy of Sciences of the United States of America 2022 Su-Feher L, Rubin AN, Silberberg SN, Catta-Preta R, Lim KJ, Ypsilanti AR, Zdilar I, McGinnis CS, McKinsey GL, Rubino TE, Hawrylycz MJ, Thompson C, Gartner ZJ, Puelles L, Zeng H, Rubenstein JLR, Nord …
Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum.
Development (Cambridge, England) 2022 Su Z, Wang Z, Lindtner S, Yang L, Shang Z, Tian Y, Guo R, You Y, Zhou W, Rubenstein JL, Yang Z, Zhang Z
LiCl treatment leads to long-term restoration of spine maturation and synaptogenesis in adult Tbr1 mutants.
Journal of neurodevelopmental disorders 2022 Fazel Darbandi S, Nelson AD, Pai EL, Bender KJ, Rubenstein JLR
Transcriptional network orchestrating regional patterning of cortical progenitors.
Proceedings of the National Academy of Sciences of the United States of America 2021 Ypsilanti AR, Pattabiraman K, Catta-Preta R, Golonzhka O, Lindtner S, Tang K, Jones IR, Abnousi A, Juric I, Hu M, Shen Y, Dickel DE, Visel A, Pennachio LA, Hawrylycz M, Thompson CL, Zeng H, Barozzi I,…
Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes.
Cell reports 2021 Markenscoff-Papadimitriou E, Binyameen F, Whalen S, Price J, Lim K, Ypsilanti AR, Catta-Preta R, Pai EL, Mu X, Xu D, Pollard KS, Nord AS, State MW, Rubenstein JL
Developmental dynamics of voltage-gated sodium channel isoform expression in the human and mouse brain.
Genome medicine 2021 Liang L, Fazel Darbandi S, Pochareddy S, Gulden FO, Gilson MC, Sheppard BK, Sahagun A, An JY, Werling DM, Rubenstein JLR, Sestan N, Bender KJ, Sanders SJ
COUP-TFI specifies the medial entorhinal cortex identity and induces differential cell adhesion to determine the integrity of its boundary with neocortex.
Science advances 2021 Feng J, Hsu WH, Patterson D, Tseng CS, Hsing HW, Zhuang ZH, Huang YT, Faedo A, Rubenstein JL, Touboul J, Chou SJ
Cracking the Codes of Cortical Glial Progenitors: Evidence for the Common Lineage of Astrocytes and Oligodendrocytes.
Neuroscience bulletin 2021 Huang H, Rubenstein JL, Qiu M
Ultraconserved enhancer function does not require perfect sequence conservation.
Nature genetics 2021 Snetkova V, Ypsilanti AR, Akiyama JA, Mannion BJ, Plajzer-Frick I, Novak CS, Harrington AN, Pham QT, Kato M, Zhu Y, Godoy J, Meky E, Hunter RD, Shi M, Kvon EZ, Afzal V, Tran S, Rubenstein JLR, Visel A…
Constructing and optimizing 3D atlases from 2D data with application to the developing mouse brain.
eLife 2021 Young DM, Fazel Darbandi S, Schwartz G, Bonzell Z, Yuruk D, Nojima M, Gole LC, Rubenstein JL, Yu W, Sanders SJ
Gene regulatory networks controlling differentiation, survival, and diversification of hypothalamic Lhx6-expressing GABAergic neurons.
Communications biology 2021 Kim DW, Liu K, Wang ZQ, Zhang YS, Bathini A, Brown MP, Lin SH, Washington PW, Sun C, Lindtner S, Lee B, Wang H, Shimogori T, Rubenstein JLR, Blackshaw S
Regulatory Elements Inserted into AAVs Confer Preferential Activity in Cortical Interneurons.
eNeuro 2020 Rubin AN, Malik R, Cho KKA, Lim KJ, Lindtner S, Robinson Schwartz SE, Vogt D, Sohal VS, Rubenstein JLR
Altered hippocampal-prefrontal communication during anxiety-related avoidance in mice deficient for the autism-associated gene Pogz.
eLife 2020 Cunniff MM, Markenscoff-Papadimitriou E, Ostrowski J, Rubenstein JL, Sohal VS
A Chromatin Accessibility Atlas of the Developing Human Telencephalon.
Cell 2020 Markenscoff-Papadimitriou E, Whalen S, Przytycki P, Thomas R, Binyameen F, Nowakowski TJ, Kriegstein AR, Sanders SJ, State MW, Pollard KS, Rubenstein JL
LacZ-reporter mapping of Dlx5/6 expression and genoarchitectural analysis of the postnatal mouse prethalamus.
The Journal of comparative neurology 2020 Puelles L, Diaz C, Stühmer T, Ferran JL, Martínez-de la Torre M, Rubenstein JLR
Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation.
eLife 2020 Pai EL, Chen J, Fazel Darbandi S, Cho FS, Chen J, Lindtner S, Chu JS, Paz JT, Vogt D, Paredes MF, Rubenstein JL
Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants.
Cell reports 2020 Fazel Darbandi S, Robinson Schwartz SE, Pai EL, Everitt A, Turner ML, Cheyette BNR, Willsey AJ, State MW, Sohal VS, Rubenstein JLR
Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog.
Cell reports 2020 Zhang Y, Liu G, Guo T, Liang XG, Du H, Yang L, Bhaduri A, Li X, Xu Z, Zhang Z, Li Z, He M, Tsyporin J, Kriegstein AR, Rubenstein JL, Yang Z, Chen B
Nf1 deletion results in depletion of the Lhx6 transcription factor and a specific loss of parvalbumin+ cortical interneurons.
Proceedings of the National Academy of Sciences of the United States of America 2020 Angara K, Pai EL, Bilinovich SM, Stafford AM, Nguyen JT, Li KX, Paul A, Rubenstein JL, Vogt D
Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.
Neuron 2020 Luo L, Ambrozkiewicz MC, Benseler F, Chen C, Dumontier E, Falkner S, Furlanis E, Gomez AM, Hoshina N, Huang WH, Hutchison MA, Itoh-Maruoka Y, Lavery LA, Li W, Maruo T, Motohashi J, Pai EL, Pelkey KA, …
Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Southwell DG, Seifikar H, Malik R, Lavi K, Vogt D, Rubenstein JL, Sohal VS
Dlx1/2 are Central and Essential Components in the Transcriptional Code for Generating Olfactory Bulb Interneurons.
Cerebral cortex (New York, N.Y. : 1991) 2019 Guo T, Liu G, Du H, Wen Y, Wei S, Li Z, Tao G, Shang Z, Song X, Zhang Z, Xu Z, You Y, Chen B, Rubenstein JL, Yang Z
Functionally Distinct Connectivity of Developmentally Targeted Striosome Neurons.
Cell reports 2019 McGregor MM, McKinsey GL, Girasole AE, Bair-Marshall CJ, Rubenstein JLR, Nelson AB
Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons.
Nature communications 2019 Malik R, Pai EL, Rubin AN, Stafford AM, Angara K, Minasi P, Rubenstein JL, Sohal VS, Vogt D
Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons.
Cell reports 2019 Lindtner S, Catta-Preta R, Tian H, Su-Feher L, Price JD, Dickel DE, Greiner V, Silberberg SN, McKinsey GL, McManus MT, Pennacchio LA, Visel A, Nord AS, Rubenstein JLR
Immature excitatory neurons develop during adolescence in the human amygdala.
Nature communications 2019 Sorrells SF, Paredes MF, Velmeshev D, Herranz-Pérez V, Sandoval K, Mayer S, Chang EF, Insausti R, Kriegstein AR, Rubenstein JL, Manuel Garcia-Verdugo J, Huang EJ, Alvarez-Buylla A
Sp9 Regulates Medial Ganglionic Eminence-Derived Cortical Interneuron Development.
Cerebral cortex (New York, N.Y. : 1991) 2019 Liu Z, Zhang Z, Lindtner S, Li Z, Xu Z, Wei S, Liang Q, Wen Y, Tao G, You Y, Chen B, Wang Y, Rubenstein JL, Yang Z
Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders.
Molecular psychiatry 2019 Sohal VS, Rubenstein JLR
Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer.
Molecular autism 2019 Forés-Martos J, Catalá-López F, Sánchez-Valle J, Ibáñez K, Tejero H, Palma-Gudiel H, Climent J, Pancaldi V, Fañanás L, Arango C, Parellada M, Baudot A, Vogt D, Rubenstein JL, Valencia A, Tabarés-…
Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function.
Cell reports 2019 Pai EL, Vogt D, Clemente-Perez A, McKinsey GL, Cho FS, Hu JS, Wimer M, Paul A, Fazel Darbandi S, Pla R, Nowakowski TJ, Goodrich LV, Paz JT, Rubenstein JLR
Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder.
Science (New York, N.Y.) 2018 An JY, Lin K, Zhu L, Werling DM, Dong S, Brand H, Wang HZ, Zhao X, Schwartz GB, Collins RL, Currall BB, Dastmalchi C, Dea J, Duhn C, Gilson MC, Klei L, Liang L, Markenscoff-Papadimitriou E, Pochareddy…
Dlx1 and Dlx2 Promote Interneuron GABA Synthesis, Synaptogenesis, and Dendritogenesis.
Cerebral cortex (New York, N.Y. : 1991) 2018 Pla R, Stanco A, Howard MA, Rubin AN, Vogt D, Mortimer N, Cobos I, Potter GB, Lindtner S, Price JD, Nord AS, Visel A, Schreiner CE, Baraban SC, Rowitch DH, Rubenstein JLR
Mouse Cntnap2 and Human CNTNAP2 ASD Alleles Cell Autonomously Regulate PV+ Cortical Interneurons.
Cerebral cortex (New York, N.Y. : 1991) 2018 Vogt D, Cho KKA, Shelton SM, Paul A, Huang ZJ, Sohal VS, Rubenstein JLR
CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brûlé E, Rowland ME, Rubenstein J, Bérubé NG
Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity.
Neuron 2018 Fazel Darbandi S, Robinson Schwartz SE, Qi Q, Catta-Preta R, Pai EL, Mandell JD, Everitt A, Rubin A, Krasnoff RA, Katzman S, Tastad D, Nord AS, Willsey AJ, Chen B, State MW, Sohal VS, Rubenstein JLR
Genomic analysis of transcriptional networks directing progression of cell states during MGE development.
Neural development 2018 Sandberg M, Taher L, Hu J, Black BL, Nord AS, Rubenstein JLR
Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development.
Cerebral cortex (New York, N.Y. : 1991) 2018 Li J, Wang C, Zhang Z, Wen Y, An L, Liang Q, Xu Z, Wei S, Li W, Guo T, Liu G, Tao G, You Y, Du H, Fu Z, He M, Chen B, Campbell K, Alvarez-Buylla A, Rubenstein JL, Yang Z
The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.
Frontiers in neuroscience 2018 Elsen GE, Bedogni F, Hodge RD, Bammler TK, MacDonald JW, Lindtner S, Rubenstein JLR, Hevner RF
SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression.
Development (Cambridge, England) 2018 Xu Z, Liang Q, Song X, Zhang Z, Lindtner S, Li Z, Wen Y, Liu G, Guo T, Qi D, Wang M, Wang C, Li H, You Y, Wang X, Chen B, Feng H, Rubenstein JL, Yang Z
Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity.
Cerebral cortex (New York, N.Y. : 1991) 2018 Raju CS, Spatazza J, Stanco A, Larimer P, Sorrells SF, Kelley KW, Nicholas CR, Paredes MF, Lui JH, Hasenstaub AR, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL, Oldham MC
An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder.
Nature genetics 2018 Werling DM, Brand H, An JY, Stone MR, Zhu L, Glessner JT, Collins RL, Dong S, Layer RM, Markenscoff-Papadimitriou E, Farrell A, Schwartz GB, Wang HZ, Currall BB, Zhao X, Dea J, Duhn C, Erdman CA, …
Tbr1 instructs laminar patterning of retinal ganglion cell dendrites.
Nature neuroscience 2018 Liu J, Reggiani JDS, Laboulaye MA, Pandey S, Chen B, Rubenstein JLR, Krishnaswamy A, Sanes JR
Ultraconserved Enhancers Are Required for Normal Development.
Cell 2018 Dickel DE, Ypsilanti AR, Pla R, Zhu Y, Barozzi I, Mannion BJ, Khin YS, Fukuda-Yuzawa Y, Plajzer-Frick I, Pickle CS, Lee EA, Harrington AN, Pham QT, Garvin TH, Kato M, Osterwalder M, Akiyama JA, Afzal …
Cortical interneuron development: a tale of time and space.
Development (Cambridge, England) 2017 Hu JS, Vogt D, Sandberg M, Rubenstein JL
The Cytokine CXCL12 Promotes Basket Interneuron Inhibitory Synapses in the Medial Prefrontal Cortex.
Cerebral cortex (New York, N.Y. : 1991) 2017 Wu PR, Cho KKA, Vogt D, Sohal VS, Rubenstein JLR
GABAergic Interneuron Differentiation in the Basal Forebrain Is Mediated through Direct Regulation of Glutamic Acid Decarboxylase Isoforms by Dlx Homeobox Transcription Factors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Le TN, Zhou QP, Cobos I, Zhang S, Zagozewski J, Japoni S, Vriend J, Parkinson T, Du G, Rubenstein JL, Eisenstat DD
Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons.
Development (Cambridge, England) 2017 Hu JS, Vogt D, Lindtner S, Sandberg M, Silberberg SN, Rubenstein JLR
Generation of pure GABAergic neurons by transcription factor programming.
Nature methods 2017 Yang N, Chanda S, Marro S, Ng YH, Janas JA, Haag D, Ang CE, Tang Y, Flores Q, Mall M, Wapinski O, Li M, Ahlenius H, Rubenstein JL, Chang HY, Buylla AA, Südhof TC, Wernig M
Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types.
Scientific reports 2017 Chen YJ, Friedman BA, Ha C, Durinck S, Liu J, Rubenstein JL, Seshagiri S, Modrusan Z
Astroglial-Mediated Remodeling of the Interhemispheric Midline Is Required for the Formation of the Corpus Callosum.
Cell reports 2016 Gobius I, Morcom L, Suárez R, Bunt J, Bukshpun P, Reardon W, Dobyns WB, Rubenstein JL, Barkovich AJ, Sherr EH, Richards LJ
Subpallial Enhancer Transgenic Lines: a Data and Tool Resource to Study Transcriptional Regulation of GABAergic Cell Fate.
Neuron 2016 Silberberg SN, Taher L, Lindtner S, Sandberg M, Nord AS, Vogt D, Mckinsey GL, Hoch R, Pattabiraman K, Zhang D, Ferran JL, Rajkovic A, Golonzhka O, Kim C, Zeng H, Puelles L, Visel A, Rubenstein JLR
Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons.
Neuron 2016 Sandberg M, Flandin P, Silberberg S, Su-Feher L, Price JD, Hu JS, Kim C, Visel A, Nord AS, Rubenstein JLR
A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients.
eLife 2016 Sun Y, Pasca SP, Portmann T, Goold C, Worringer KA, Guan W, Chan KC, Gai H, Vogt D, Chen YJ, Mao R, Chan K, Rubenstein JL, Madison DV, Hallmayer J, Froehlich-Santino WM, Bernstein JA, Dolmetsch RE
The Zinc Finger Transcription Factor Sp9 Is Required for the Development of Striatopallidal Projection Neurons.
Cell reports 2016 Zhang Q, Zhang Y, Wang C, Xu Z, Liang Q, An L, Li J, Liu Z, You Y, He M, Mao Y, Chen B, Xiong ZQ, Rubenstein JL, Yang Z
TBR1 regulates autism risk genes in the developing neocortex.
Genome research 2016 Notwell JH, Heavner WE, Darbandi SF, Katzman S, McKenna WL, Ortiz-Londono CF, Tastad D, Eckler MJ, Rubenstein JL, McConnell SK, Chen B, Bejerano G
Radial derivatives of the mouse ventral pallium traced with Dbx1-LacZ reporters.
Journal of chemical neuroanatomy 2015 Puelles L, Medina L, Borello U, Legaz I, Teissier A, Pierani A, Rubenstein JL
Accelerated Evolution of Enhancer Hotspots in the Mammal Ancestor.
Molecular biology and evolution 2015 Holloway AK, Bruneau BG, Sukonnik T, Rubenstein JL, Pollard KS
Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis.
Developmental cell 2015 Prochazka J, Prochazkova M, Du W, Spoutil F, Tureckova J, Hoch R, Shimogori T, Sedlacek R, Rubenstein JL, Wittmann T, Klein OD
Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons.
Neuron 2015 Golonzhka O, Nord A, Tang PLF, Lindtner S, Ypsilanti AR, Ferretti E, Visel A, Selleri L, Rubenstein JLR
EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex.
Development (Cambridge, England) 2015 Lim JW, Donahoo AL, Bunt J, Edwards TJ, Fenlon LR, Liu Y, Zhou J, Moldrich RX, Piper M, Gobius I, Bailey TL, Wray NR, Kessaris N, Poo MM, Rubenstein JL, Richards LJ
Fgf15 regulates thalamic development by controlling the expression of proneural genes.
Brain structure & function 2015 Martinez-Ferre A, Lloret-Quesada C, Prakash N, Wurst W, Rubenstein JL, Martinez S
Transcriptional and epigenetic mechanisms of early cortical development: An examination of how Pax6 coordinates cortical development.
The Journal of comparative neurology 2015 Ypsilanti AR, Rubenstein JL
miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability.
Cell reports 2015 Parchem RJ, Moore N, Fish JL, Parchem JG, Braga TT, Shenoy A, Oldham MC, Rubenstein JL, Schneider RA, Blelloch R
OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum.
Cell reports 2015 Hoch RV, Lindtner S, Price JD, Rubenstein JL
Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2.
Human molecular genetics 2015 Cesario JM, Landin Malt A, Deacon LJ, Sandberg M, Vogt D, Tang Z, Zhao Y, Brown S, Rubenstein JL, Jeong J
Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity.
Pain 2015 Bráz JM, Wang X, Guan Z, Rubenstein JL, Basbaum AI
Cux2-positive radial glial cells generate diverse subtypes of neocortical projection neurons and macroglia.
Neuron 2015 Eckler MJ, Nguyen TD, McKenna WL, Fastow BL, Guo C, Rubenstein JLR, Chen B
The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles.
Cell reports 2015 Vogt D, Cho KKA, Lee AT, Sohal VS, Rubenstein JLR
Viral-mediated Labeling and Transplantation of Medial Ganglionic Eminence (MGE) Cells for In Vivo Studies.
Journal of visualized experiments : JoVE 2015 Vogt D, Wu PR, Sorrells SF, Arnold C, Alvarez-Buylla A, Rubenstein JL
Molecular codes defining rostrocaudal domains in the embryonic mouse hypothalamus.
Frontiers in neuroanatomy 2015 Ferran JL, Puelles L, Rubenstein JL
Fgf signaling controls the telencephalic distribution of Fgf-expressing progenitors generated in the rostral patterning center.
Neural development 2015 Hoch RV, Clarke JA, Rubenstein JL
A new scenario of hypothalamic organization: rationale of new hypotheses introduced in the updated prosomeric model.
Frontiers in neuroanatomy 2015 Puelles L, Rubenstein JL
Gamma rhythms link prefrontal interneuron dysfunction with cognitive inflexibility in Dlx5/6(+/-) mice.
Neuron 2015 Cho KK, Hoch R, Lee AT, Patel T, Rubenstein JL, Sohal VS
Genomic perspectives of transcriptional regulation in forebrain development.
Neuron 2015 Nord AS, Pattabiraman K, Visel A, Rubenstein JLR
An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females.
Cell reports 2014 Correa SM, Newstrom DW, Warne JP, Flandin P, Cheung CC, Lin-Moore AT, Pierce AA, Xu AW, Rubenstein JL, Ingraham HA
Differential regulation of microtubule severing by APC underlies distinct patterns of projection neuron and interneuron migration.
Developmental cell 2014 Eom TY, Stanco A, Guo J, Wilkins G, Deslauriers D, Yan J, Monckton C, Blair J, Oon E, Perez A, Salas E, Oh A, Ghukasyan V, Snider WD, Rubenstein JL, Anton ES
NPAS1 represses the generation of specific subtypes of cortical interneurons.
Neuron 2014 Stanco A, Pla R, Vogt D, Chen Y, Mandal S, Walker J, Hunt RF, Lindtner S, Erdman CA, Pieper AA, Hamilton SP, Xu D, Baraban SC, Rubenstein JL
A class of GABAergic neurons in the prefrontal cortex sends long-range projections to the nucleus accumbens and elicits acute avoidance behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Lee AT, Vogt D, Rubenstein JL, Sohal VS
Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Aβ accumulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Tong LM, Djukic B, Arnold C, Gillespie AK, Yoon SY, Wang MM, Zhang O, Knoferle J, Rubenstein JL, Alvarez-Buylla A, Huang Y
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron 2014 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, …
Major progress towards elucidating brain wiring diagrams.
The Journal of comparative neurology 2014 Rubenstein JL
Transcriptional regulation of enhancers active in protodomains of the developing cerebral cortex.
Neuron 2014 Pattabiraman K, Golonzhka O, Lindtner S, Nord AS, Taher L, Hoch R, Silberberg SN, Zhang D, Chen B, Zeng H, Pennacchio LA, Puelles L, Visel A, Rubenstein JL
Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position.
Neuron 2014 Vogt D, Hunt RF, Mandal S, Sandberg M, Silberberg SN, Nagasawa T, Yang Z, Baraban SC, Rubenstein JL
Interneurons from embryonic development to cell-based therapy.
Science (New York, N.Y.) 2014 Southwell DG, Nicholas CR, Basbaum AI, Stryker MP, Kriegstein AR, Rubenstein JL, Alvarez-Buylla A
Multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex.
Neural development 2014 Eckler MJ, Larkin KA, McKenna WL, Katzman S, Guo C, Roque R, Visel A, Rubenstein JL, Chen B
Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain.
Neuron 2014 Silbereis JC, Nobuta H, Tsai HH, Heine VM, McKinsey GL, Meijer DH, Howard MA, Petryniak MA, Potter GB, Alberta JA, Baraban SC, Stiles CD, Rubenstein JL, Rowitch DH
Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition.
Neuron 2013 Lee AT, Gee SM, Vogt D, Patel T, Rubenstein JL, Sohal VS
Rapid and pervasive changes in genome-wide enhancer usage during mammalian development.
Cell 2013 Nord AS, Blow MJ, Attanasio C, Akiyama JA, Holt A, Hosseini R, Phouanenavong S, Plajzer-Frick I, Shoukry M, Afzal V, Rubenstein JL, Rubin EM, Pennacchio LA, Visel A
Bidirectional homeostatic plasticity induced by interneuron cell death and transplantation in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2013 Howard MA, Rubenstein JL, Baraban SC
Fezf2 expression identifies a multipotent progenitor for neocortical projection neurons, astrocytes, and oligodendrocytes.
Neuron 2013 Guo C, Eckler MJ, McKenna WL, McKinsey GL, Rubenstein JL, Chen B
Many human accelerated regions are developmental enhancers.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2013 Capra JA, Erwin GD, McKinsey G, Rubenstein JL, Pollard KS
Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Mandal S, Stanco A, Buys ES, Enikolopov G, Rubenstein JL
Ldb1 is essential for development of Nkx2.1 lineage derived GABAergic and cholinergic neurons in the telencephalon.
Developmental biology 2013 Zhao Y, Flandin P, Vogt D, Blood A, Hermesz E, Westphal H, Rubenstein JL
Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences.
Nature neuroscience 2013 Hansen DV, Lui JH, Flandin P, Yoshikawa K, Rubenstein JL, Alvarez-Buylla A, Kriegstein AR
Subcortical origins of human and monkey neocortical interneurons.
Nature neuroscience 2013 Ma T, Wang C, Wang L, Zhou X, Tian M, Zhang Q, Zhang Y, Li J, Liu Z, Cai Y, Liu F, You Y, Chen C, Campbell K, Song H, Ma L, Rubenstein JL, Yang Z
Dapper antagonist of catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain GABAergic interneurons.
PloS one 2013 Arguello A, Yang X, Vogt D, Stanco A, Rubenstein JL, Cheyette BN
A subpopulation of individual neural progenitors in the mammalian dorsal pallium generates both projection neurons and interneurons in vitro.
Stem cells (Dayton, Ohio) 2013 Cai Y, Zhang Y, Shen Q, Rubenstein JL, Yang Z
GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior.
Nature neuroscience 2013 Hunt RF, Girskis KM, Rubenstein JL, Alvarez-Buylla A, Baraban SC
Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development.
Cell stem cell 2013 Nicholas CR, Chen J, Tang Y, Southwell DG, Chalmers N, Vogt D, Arnold CM, Chen YJ, Stanley EG, Elefanty AG, Sasai Y, Alvarez-Buylla A, Rubenstein JL, Kriegstein AR
Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.
American journal of human genetics 2013 Miraoui H, Dwyer AA, Sykiotis GP, Plummer L, Chung W, Feng B, Beenken A, Clarke J, Pers TH, Dworzynski P, Keefe K, Niedziela M, Raivio T, Crowley WF, Seminara SB, Quinton R, Hughes VA, Kumanov P, …
Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants.
The Journal of comparative neurology 2013 Wang B, Long JE, Flandin P, Pla R, Waclaw RR, Campbell K, Rubenstein JL
Use of "MGE enhancers" for labeling and selection of embryonic stem cell-derived medial ganglionic eminence (MGE) progenitors and neurons.
PloS one 2013 Chen YJ, Vogt D, Wang Y, Visel A, Silberberg SN, Nicholas CR, Danjo T, Pollack JL, Pennacchio LA, Anderson S, Sasai Y, Baraban SC, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL
Inverse cancer comorbidity: a serendipitous opportunity to gain insight into CNS disorders.
Nature reviews. Neuroscience 2013 Tabarés-Seisdedos R, Rubenstein JL
CoupTFI interacts with retinoic acid signaling during cortical development.
PloS one 2013 Harrison-Uy SJ, Siegenthaler JA, Faedo A, Rubenstein JL, Pleasure SJ
New insights into the classification and nomenclature of cortical GABAergic interneurons.
Nature reviews. Neuroscience 2013 DeFelipe J, López-Cruz PL, Benavides-Piccione R, Bielza C, Larrañaga P, Anderson S, Burkhalter A, Cauli B, Fairén A, Feldmeyer D, Fishell G, Fitzpatrick D, Freund TF, González-Burgos G, Hestrin S, …
Nuclear receptor COUP-TFII-expressing neocortical interneurons are derived from the medial and lateral/caudal ganglionic eminence and define specific subsets of mature interneurons.
The Journal of comparative neurology 2013 Cai Y, Zhang Q, Wang C, Zhang Y, Ma T, Zhou X, Tian M, Rubenstein JL, Yang Z
A high-resolution enhancer atlas of the developing telencephalon.
Cell 2013 Visel A, Taher L, Girgis H, May D, Golonzhka O, Hoch RV, McKinsey GL, Pattabiraman K, Silberberg SN, Blow MJ, Hansen DV, Nord AS, Akiyama JA, Holt A, Hosseini R, Phouanenavong S, Plajzer-Frick I, …
Sp8 and COUP-TF1 reciprocally regulate patterning and Fgf signaling in cortical progenitors.
Cerebral cortex (New York, N.Y. : 1991) 2013 Borello U, Madhavan M, Vilinsky I, Faedo A, Pierani A, Rubenstein J, Campbell K
Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.
Neuron 2013 McKinsey GL, Lindtner S, Trzcinski B, Visel A, Pennacchio LA, Huylebroeck D, Higashi Y, Rubenstein JL
Intrinsically determined cell death of developing cortical interneurons.
Nature 2012 Southwell DG, Paredes MF, Galvao RP, Jones DL, Froemke RC, Sebe JY, Alfaro-Cervello C, Tang Y, Garcia-Verdugo JM, Rubenstein JL, Baraban SC, Alvarez-Buylla A
Cleft palate defect of Dlx1/2-/- mutant mice is caused by lack of vertical outgrowth in the posterior palate.
Developmental dynamics : an official publication of the American Association of Anatomists 2012 Jeong J, Cesario J, Zhao Y, Burns L, Westphal H, Rubenstein JL
Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development.
Proceedings of the National Academy of Sciences of the United States of America 2012 Li Y, Yui D, Luikart BW, McKay RM, Li Y, Rubenstein JL, Parada LF
Subcortical visual shell nuclei targeted by ipRGCs develop from a Sox14+-GABAergic progenitor and require Sox14 to regulate daily activity rhythms.
Neuron 2012 Delogu A, Sellers K, Zagoraiou L, Bocianowska-Zbrog A, Mandal S, Guimera J, Rubenstein JL, Sugden D, Jessell T, Lumsden A
Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission.
Nature 2012 Han S, Tai C, Westenbroek RE, Yu FH, Cheah CS, Potter GB, Rubenstein JL, Scheuer T, de la Iglesia HO, Catterall WA
Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2012 Cheah CS, Yu FH, Westenbroek RE, Kalume FK, Oakley JC, Potter GB, Rubenstein JL, Catterall WA
Hilar GABAergic interneuron activity controls spatial learning and memory retrieval.
PloS one 2012 Andrews-Zwilling Y, Gillespie AK, Kravitz AV, Nelson AB, Devidze N, Lo I, Yoon SY, Bien-Ly N, Ring K, Zwilling D, Potter GB, Rubenstein JL, Kreitzer AC, Huang Y
Chronic reduction in inhibition reduces receptive field size in mouse auditory cortex.
Proceedings of the National Academy of Sciences of the United States of America 2012 Seybold BA, Stanco A, Cho KK, Potter GB, Kim C, Sohal VS, Rubenstein JL, Schreiner CE
Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain.
Neuron 2012 Bráz JM, Sharif-Naeini R, Vogt D, Kriegstein A, Alvarez-Buylla A, Rubenstein JL, Basbaum AI
COUP-TFII controls amygdala patterning by regulating neuropilin expression.
Development (Cambridge, England) 2012 Tang K, Rubenstein JL, Tsai SY, Tsai MJ
TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Sanchez-Ortiz E, Yui D, Song D, Li Y, Rubenstein JL, Reichardt LF, Parada LF
Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons.
Stem cells and development 2012 Martín-Ibáñez R, Crespo E, Esgleas M, Urban N, Wang B, Waclaw R, Georgopoulos K, Martínez S, Campbell K, Vicario-Abejón C, Alberch J, Chan S, Kastner P, Rubenstein JL, Canals JM
A subpopulation of dorsal lateral/caudal ganglionic eminence-derived neocortical interneurons expresses the transcription factor Sp8.
Cerebral cortex (New York, N.Y. : 1991) 2011 Ma T, Zhang Q, Cai Y, You Y, Rubenstein JL, Yang Z
Dlx6 regulates molecular properties of the striatum and central nucleus of the amygdala.
The Journal of comparative neurology 2011 Wang B, Lufkin T, Rubenstein JL
Influence of a subtype of inhibitory interneuron on stimulus-specific responses in visual cortex.
Cerebral cortex (New York, N.Y. : 1991) 2011 Mao R, Schummers J, Knoblich U, Lacey CJ, Van Wart A, Cobos I, Kim C, Huguenard JR, Rubenstein JL, Sur M
Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors.
Neuron 2011 Flandin P, Zhao Y, Vogt D, Jeong J, Long J, Potter G, Westphal H, Rubenstein JL
Deriving excitatory neurons of the neocortex from pluripotent stem cells.
Neuron 2011 Hansen DV, Rubenstein JL, Kriegstein AR
No paradox, no progress: inverse cancer comorbidity in people with other complex diseases.
The Lancet. Oncology 2011 Tabarés-Seisdedos R, Dumont N, Baudot A, Valderas JM, Climent J, Valencia A, Crespo-Facorro B, Vieta E, Gómez-Beneyto M, Martínez S, Rubenstein JL
Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons.
Journal of neurophysiology 2011 Jones DL, Howard MA, Stanco A, Rubenstein JL, Baraban SC
Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Danjo T, Eiraku M, Muguruma K, Watanabe K, Kawada M, Yanagawa Y, Rubenstein JL, Sasai Y
CXCR4 and CXCR7 have distinct functions in regulating interneuron migration.
Neuron 2011 Wang Y, Li G, Stanco A, Long JE, Crawford D, Potter GB, Pleasure SJ, Behrens T, Rubenstein JL
Identification of direct downstream targets of Dlx5 during early inner ear development.
Human molecular genetics 2011 Sajan SA, Rubenstein JL, Warchol ME, Lovett M
Tbr1 and Fezf2 regulate alternate corticofugal neuronal identities during neocortical development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 McKenna WL, Betancourt J, Larkin KA, Abrams B, Guo C, Rubenstein JL, Chen B
A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning.
Development (Cambridge, England) 2010 Lek M, Dias JM, Marklund U, Uhde CW, Kurdija S, Lei Q, Sussel L, Rubenstein JL, Matise MP, Arnold HH, Jessell TM, Ericson J
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes.
Nature 2010 Chao HT, Chen H, Samaco RC, Xue M, Chahrour M, Yoo J, Neul JL, Gong S, Lu HC, Heintz N, Ekker M, Rubenstein JL, Noebels JL, Rosenmund C, Zoghbi HY
Annual Research Review: Development of the cerebral cortex: implications for neurodevelopmental disorders.
Journal of child psychology and psychiatry, and allied disciplines 2010 Rubenstein JL
An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain.
Development (Cambridge, England) 2010 Poitras L, Yu M, Lesage-Pelletier C, Macdonald RB, Gagné JP, Hatch G, Kelly I, Hamilton SP, Rubenstein JL, Poirier GG, Ekker M
New neurons clear the path of astrocytic processes for their rapid migration in the adult brain.
Neuron 2010 Kaneko N, Marín O, Koike M, Hirota Y, Uchiyama Y, Wu JY, Lu Q, Tessier-Lavigne M, Alvarez-Buylla A, Okano H, Rubenstein JL, Sawamoto K
Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.
Proceedings of the National Academy of Sciences of the United States of America 2010 Bedogni F, Hodge RD, Elsen GE, Nelson BR, Daza RA, Beyer RP, Bammler TK, Rubenstein JL, Hevner RF
Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Wang Y, Dye CA, Sohal V, Long JE, Estrada RC, Roztocil T, Lufkin T, Deisseroth K, Baraban SC, Rubenstein JL
Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder.
Current opinion in neurology 2010 Rubenstein JL
Comparative mouse brain tractography of diffusion magnetic resonance imaging.
NeuroImage 2010 Moldrich RX, Pannek K, Hoch R, Rubenstein JL, Kurniawan ND, Richards LJ
Repression of Fgf signaling by sprouty1-2 regulates cortical patterning in two distinct regions and times.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Faedo A, Borello U, Rubenstein JL
Erratum to: Role for TGF-β superfamily signaling in telencephalic GABAergic neuron development.
Journal of neurodevelopmental disorders 2010 Maira M, Long JE, Lee AY, Rubenstein JL, Stifani S
The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Flandin P, Kimura S, Rubenstein JL
Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons.
The Journal of comparative neurology 2010 Martín-Ibáñez R, Crespo E, Urbán N, Sergent-Tanguy S, Herranz C, Jaumot M, Valiente M, Long JE, Pineda JR, Andreu C, Rubenstein JL, Marín O, Georgopoulos K, Mengod G, Fariñas I, Bachs O, Alberch J, …
A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice.
Developmental biology 2010 Endoh-Yamagami S, Karkar KM, May SR, Cobos I, Thwin MT, Long JE, Ashique AM, Zarbalis K, Rubenstein JL, Peterson AS
Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice.
Development (Cambridge, England) 2009 Han J, Mayo J, Xu X, Li J, Bringas P, Maas RL, Rubenstein JL, Chai Y
Role for TGF-beta superfamily signaling in telencephalic GABAergic neuron development.
Journal of neurodevelopmental disorders 2009 Maira M, Long JE, Lee AY, Rubenstein JL, Stifani S
Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y(+), proopiomelanocortin(+), and tyrosine hydroxylase(+) neurons in neonatal and adult mice.
The Journal of comparative neurology 2009 Yee CL, Wang Y, Anderson S, Ekker M, Rubenstein JL
Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice.
Proceedings of the National Academy of Sciences of the United States of America 2009 Baraban SC, Southwell DG, Estrada RC, Jones DL, Sebe JY, Alfaro-Cervello C, García-Verdugo JM, Rubenstein JL, Alvarez-Buylla A
The organization of the transcriptional network in specific neuronal classes.
Molecular systems biology 2009 Winden KD, Oldham MC, Mirnics K, Ebert PJ, Swan CH, Levitt P, Rubenstein JL, Horvath S, Geschwind DH
Reduced conditioned fear response in mice that lack Dlx1 and show subtype-specific loss of interneurons.
Journal of neurodevelopmental disorders 2009 Mao R, Page DT, Merzlyak I, Kim C, Tecott LH, Janak PH, Rubenstein JL, Sur M
The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
PLoS genetics 2009 Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein JL, Livesey FJ
Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.
Cerebral cortex (New York, N.Y. : 1991) 2009 Long JE, Cobos I, Potter GB, Rubenstein JL
Genes and signaling events that establish regional patterning of the mammalian forebrain.
Seminars in cell & developmental biology 2009 Hoch RV, Rubenstein JL, Pleasure S
Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.
The Journal of comparative neurology 2009 Long JE, Swan C, Liang WS, Cobos I, Potter GB, Rubenstein JL
Generation of Cre-transgenic mice using Dlx1/Dlx2 enhancers and their characterization in GABAergic interneurons.
Molecular and cellular neurosciences 2008 Potter GB, Petryniak MA, Shevchenko E, McKinsey GL, Ekker M, Rubenstein JL
Autism and brain development.
Cell 2008 Walsh CA, Morrow EM, Rubenstein JL
Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Colasante G, Collombat P, Raimondi V, Bonanomi D, Ferrai C, Maira M, Yoshikawa K, Mansouri A, Valtorta F, Rubenstein JL, Broccoli V
Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants.
The Journal of comparative neurology 2008 Zhao Y, Flandin P, Long JE, Cuesta MD, Westphal H, Rubenstein JL
Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs.
Development (Cambridge, England) 2008 Jeong J, Li X, McEvilly RJ, Rosenfeld MG, Lufkin T, Rubenstein JL
Functional disturbances in the striatum by region-specific ablation of NMDA receptors.
Proceedings of the National Academy of Sciences of the United States of America 2008 Ohtsuka N, Tansky MF, Kuang H, Kourrich S, Thomas MJ, Rubenstein JL, Ekker M, Leeman SE, Tsien JZ
Characterization of a distinct subpopulation of striatal projection neurons expressing the Dlx genes in the basal ganglia through the activity of the I56ii enhancer.
Developmental biology 2008 Ghanem N, Yu M, Poitras L, Rubenstein JL, Ekker M
Distal-less homeobox transcription factors regulate development and maturation of natural killer cells.
Proceedings of the National Academy of Sciences of the United States of America 2008 Sunwoo JB, Kim S, Yang L, Naik T, Higuchi DA, Rubenstein JL, Yokoyama WM
FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development.
Neural development 2008 Borello U, Cobos I, Long JE, McWhirter JR, Murre C, Rubenstein JL
Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2.
The Journal of comparative neurology 2008 Cholfin JA, Rubenstein JL
Compartment-specific transcription factors orchestrate angiogenesis gradients in the embryonic brain.
Nature neuroscience 2008 Vasudevan A, Long JE, Crandall JE, Rubenstein JL, Bhide PG
Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Li G, Adesnik H, Li J, Long J, Nicoll RA, Rubenstein JL, Pleasure SJ
Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development.
The Journal of comparative neurology 2008 García-López M, Abellán A, Legaz I, Rubenstein JL, Puelles L, Medina L
COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling.
Cerebral cortex (New York, N.Y. : 1991) 2007 Faedo A, Tomassy GS, Ruan Y, Teichmann H, Krauss S, Pleasure SJ, Tsai SY, Tsai MJ, Studer M, Rubenstein JL
Conserved pattern of OTP-positive cells in the paraventricular nucleus and other hypothalamic sites of tetrapods.
Brain research bulletin 2007 Bardet SM, Martinez-de-la-Torre M, Northcutt RG, Rubenstein JL, Puelles L
Abnormal social behaviors in mice lacking Fgf17.
Genes, brain, and behavior 2007 Scearce-Levie K, Roberson ED, Gerstein H, Cholfin JA, Mandiyan VS, Shah NM, Rubenstein JL, Mucke L
Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Flames N, Pla R, Gelman DM, Rubenstein JL, Puelles L, Marín O
Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain.
Neuron 2007 Petryniak MA, Potter GB, Rowitch DH, Rubenstein JL
A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Kohwi M, Petryniak MA, Long JE, Ekker M, Obata K, Yanagawa Y, Rubenstein JL, Alvarez-Buylla A
Dlx transcription factors promote migration through repression of axon and dendrite growth.
Neuron 2007 Cobos I, Borello U, Rubenstein JL
Distinct cis-regulatory elements from the Dlx1/Dlx2 locus mark different progenitor cell populations in the ganglionic eminences and different subtypes of adult cortical interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Ghanem N, Yu M, Long J, Hatch G, Rubenstein JL, Ekker M
Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Colombo E, Collombat P, Colasante G, Bianchi M, Long J, Mansouri A, Rubenstein JL, Broccoli V
Patterning of frontal cortex subdivisions by Fgf17.
Proceedings of the National Academy of Sciences of the United States of America 2007 Cholfin JA, Rubenstein JL
Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Long JE, Garel S, Alvarez-Dolado M, Yoshikawa K, Osumi N, Alvarez-Buylla A, Rubenstein JL
Genetic regulation of prefrontal cortex development and function.
Novartis Foundation symposium 2007 Cholfin JA, Rubenstein JL
The NMR structure of the gpU tail-terminator protein from bacteriophage lambda: identification of sites contributing to Mg(II)-mediated oligomerization and biological function.
Journal of molecular biology 2006 Edmonds L, Liu A, Kwan JJ, Avanessy A, Caracoglia M, Yang I, Maxwell KL, Rubenstein J, Davidson AR, Donaldson LW
Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway.
Neuroscience 2006 Zhou CJ, Borello U, Rubenstein JL, Pleasure SJ
The endocannabinoid system controls key epileptogenic circuits in the hippocampus.
Neuron 2006 Monory K, Massa F, Egertová M, Eder M, Blaudzun H, Westenbroek R, Kelsch W, Jacob W, Marsch R, Ekker M, Long J, Rubenstein JL, Goebbels S, Nave KA, During M, Klugmann M, Wölfel B, Dodt HU, …
Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Alvarez-Dolado M, Calcagnotto ME, Karkar KM, Southwell DG, Jones-Davis DM, Estrada RC, Rubenstein JL, Alvarez-Buylla A, Baraban SC
Cellular patterns of transcription factor expression in developing cortical interneurons.
Cerebral cortex (New York, N.Y. : 1991) 2006 Cobos I, Long JE, Thwin MT, Rubenstein JL
Can autism speak to neuroscience?
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Moldin SO, Rubenstein JL, Hyman SE
Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers.
Development (Cambridge, England) 2006 Storm EE, Garel S, Borello U, Hebert JM, Martinez S, McConnell SK, Martin GR, Rubenstein JL
Severe hearing loss in Dlxl mutant mice.
Hearing research 2006 Polley DB, Cobos I, Merzenich MM, Rubenstein JL
New neurons follow the flow of cerebrospinal fluid in the adult brain.
Science (New York, N.Y.) 2006 Sawamoto K, Wichterle H, Gonzalez-Perez O, Cholfin JA, Yamada M, Spassky N, Murcia NS, Garcia-Verdugo JM, Marin O, Rubenstein JL, Tessier-Lavigne M, Okano H, Alvarez-Buylla A
Patterning and plasticity of the cerebral cortex.
Science (New York, N.Y.) 2005 Sur M, Rubenstein JL
Analysis of four DLX homeobox genes in autistic probands.
BMC genetics 2005 Hamilton SP, Woo JM, Carlson EJ, Ghanem N, Ekker M, Rubenstein JL
Reassessing the Dlx code: the genetic regulation of branchial arch skeletal pattern and development.
Journal of anatomy 2005 Depew MJ, Simpson CA, Morasso M, Rubenstein JL
Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Bulfone A, Carotenuto P, Faedo A, Aglio V, Garzia L, Bello AM, Basile A, Andrè A, Cocchia M, Guardiola O, Ballabio A, Rubenstein JL, Zollo M
Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Kohwi M, Osumi N, Rubenstein JL, Alvarez-Buylla A
Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy.
Nature neuroscience 2005 Cobos I, Calcagnotto ME, Vilaythong AJ, Thwin MT, Noebels JL, Baraban SC, Rubenstein JL
The vertebrate ortholog of Aristaless is regulated by Dlx genes in the developing forebrain.
The Journal of comparative neurology 2005 Cobos I, Broccoli V, Rubenstein JL
The nuclear receptor COUP-TFI represses differentiation of Cajal-Retzius cells.
Brain research bulletin 2005 Studer M, Filosa A, Rubenstein JL
Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families.
The Journal of biological chemistry 2005 Givens ML, Rave-Harel N, Goonewardena VD, Kurotani R, Berdy SE, Swan CH, Rubenstein JL, Robert B, Mellon PL
Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina.
Development (Cambridge, England) 2004 de Melo J, Du G, Fonseca M, Gillespie LA, Turk WJ, Rubenstein JL, Eisenstat DD
Identification of Tbr-1/CASK complex target genes in neurons.
Journal of neurochemistry 2004 Wang TF, Ding CN, Wang GS, Luo SC, Lin YL, Ruan Y, Hevner R, Rubenstein JL, Hsueh YP
Identification and characterization of a novel transcript down-regulated in Dlx1/Dlx2 and up-regulated in Pax6 mutant telencephalon.
Developmental dynamics : an official publication of the American Association of Anatomists 2004 Faedo A, Quinn JC, Stoney P, Long JE, Dye C, Zollo M, Rubenstein JL, Price DJ, Bulfone A
Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1.
Neuron 2004 Flames N, Long JE, Garratt AN, Fischer TM, Gassmann M, Birchmeier C, Lai C, Rubenstein JL, Marín O
Fgf8 regulates the development of intra-neocortical projections.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Huffman KJ, Garel S, Rubenstein JL
Id4 regulates neural progenitor proliferation and differentiation in vivo.
Development (Cambridge, England) 2004 Yun K, Mantani A, Garel S, Rubenstein J, Israel MA
Expression of regulatory genes during differentiation of thalamic nuclei in mouse and monkey.
The Journal of comparative neurology 2004 Jones EG, Rubenstein JL
Intermediate targets in formation of topographic projections: inputs from the thalamocortical system.
Trends in neurosciences 2004 Garel S, Rubenstein JL
A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development.
PLoS biology 2004 Zarbalis K, May SR, Shen Y, Ekker M, Rubenstein JL, Peterson AS
Expression of Dbx1, Neurogenin 2, Semaphorin 5A, Cadherin 8, and Emx1 distinguish ventral and lateral pallial histogenetic divisions in the developing mouse claustroamygdaloid complex.
The Journal of comparative neurology 2004 Medina L, Legaz I, González G, De Castro F, Rubenstein JL, Puelles L
In vivo characterization of the Nkx2.1 promoter/enhancer elements in transgenic mice.
Gene 2004 Pan Q, Li C, Xiao J, Kimura S, Rubenstein J, Puelles L, Minoo P
Origins of cortical interneuron subtypes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Xu Q, Cobos I, De La Cruz E, Rubenstein JL, Anderson SA
Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor.
Development (Cambridge, England) 2003 Liu R, Cai J, Hu X, Tan M, Qi Y, German M, Rubenstein J, Sander M, Qiu M
Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4.
Development (Cambridge, England) 2003 Blackshear PJ, Graves JP, Stumpo DJ, Cobos I, Rubenstein JL, Zeldin DC
Model of autism: increased ratio of excitation/inhibition in key neural systems.
Genes, brain, and behavior 2003 Rubenstein JL, Merzenich MM
Forebrain gene expression domains and the evolving prosomeric model.
Trends in neurosciences 2003 Puelles L, Rubenstein JL
The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain.
Proceedings of the National Academy of Sciences of the United States of America 2003 Zhao Y, Marín O, Hermesz E, Powell A, Flames N, Palkovits M, Rubenstein JL, Westphal H
Patterning of the lateral ganglionic eminence by the Gsh1 and Gsh2 homeobox genes regulates striatal and olfactory bulb histogenesis and the growth of axons through the basal ganglia.
The Journal of comparative neurology 2003 Yun K, Garel S, Fischman S, Rubenstein JL
Directional guidance of interneuron migration to the cerebral cortex relies on subcortical Slit1/2-independent repulsion and cortical attraction.
Development (Cambridge, England) 2003 Marín O, Plump AS, Flames N, Sánchez-Camacho C, Tessier-Lavigne M, Rubenstein JL
Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamus.
Molecular and cellular neurosciences 2003 Andrews GL, Yun K, Rubenstein JL, Mastick GS
Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants.
Development (Cambridge, England) 2003 Garel S, Huffman KJ, Rubenstein JL
Regulatory roles of conserved intergenic domains in vertebrate Dlx bigene clusters.
Genome research 2003 Ghanem N, Jarinova O, Amores A, Long Q, Hatch G, Park BK, Rubenstein JL, Ekker M
Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding.
The Journal of comparative neurology 2003 Bishop KM, Garel S, Nakagawa Y, Rubenstein JL, O'Leary DD
Beyond laminar fate: toward a molecular classification of cortical projection/pyramidal neurons.
Developmental neuroscience 2003 Hevner RF, Daza RA, Rubenstein JL, Stunnenberg H, Olavarria JF, Englund C
Cell migration in the forebrain.
Annual review of neuroscience 2003 Marín O, Rubenstein JL
Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain.
Proceedings of the National Academy of Sciences of the United States of America 2003 Storm EE, Rubenstein JL, Martin GR
DLX5 regulates development of peripheral and central components of the olfactory system.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 Long JE, Garel S, Depew MJ, Tobet S, Rubenstein JL
Developmental functions of the Distal-less/Dlx homeobox genes.
Development (Cambridge, England) 2002 Panganiban G, Rubenstein JL
Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 Gorski JA, Talley T, Qiu M, Puelles L, Rubenstein JL, Jones KR
Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis.
Mechanisms of development 2002 Faedo A, Ficara F, Ghiani M, Aiuti A, Rubenstein JL, Bulfone A
Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.
Neuron 2002 Bagri A, Marín O, Plump AS, Mak J, Pleasure SJ, Rubenstein JL, Tessier-Lavigne M
Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles.
Neuroscience 2002 Ohkubo Y, Chiang C, Rubenstein JL
Ectopic expression of the Dlx genes induces glutamic acid decarboxylase and Dlx expression.
Development (Cambridge, England) 2002 Stühmer T, Anderson SA, Ekker M, Rubenstein JL
Expression from a Dlx gene enhancer marks adult mouse cortical GABAergic neurons.
Cerebral cortex (New York, N.Y. : 1991) 2002 Stühmer T, Puelles L, Ekker M, Rubenstein JL
Expression patterns of Wnt8b and Wnt7b in the chicken embryonic brain suggest a correlation with forebrain patterning centers and morphogenesis.
Neuroscience 2002 Garda AL, Puelles L, Rubenstein JL, Medina L
A long, remarkable journey: tangential migration in the telencephalon.
Nature reviews. Neuroscience 2001 Marín O, Rubenstein JL
Fate map of the avian anterior forebrain at the four-somite stage, based on the analysis of quail-chick chimeras.
Developmental biology 2001 Cobos I, Shimamura K, Rubenstein JL, Martínez S, Puelles L
Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins.
Brain research. Developmental brain research 2001 Yu G, Zerucha T, Ekker M, Rubenstein JL
Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation.
Development (Cambridge, England) 2001 Selleri L, Depew MJ, Jacobs Y, Chanda SK, Tsang KY, Cheah KS, Rubenstein JL, O'Gorman S, Cleary ML
The CRE/CREB pathway is transiently expressed in thalamic circuit development and contributes to refinement of retinogeniculate axons.
Neuron 2001 Pham TA, Rubenstein JL, Silva AJ, Storm DR, Stryker MP
Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions.
Science (New York, N.Y.) 2001 Marín O, Yaron A, Bagri A, Tessier-Lavigne M, Rubenstein JL
Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor.
Development (Cambridge, England) 2001 Qi Y, Cai J, Wu Y, Wu R, Lee J, Fu H, Rao M, Sussel L, Rubenstein J, Qiu M
Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH.
Development (Cambridge, England) 2001 Schneider RA, Hu D, Rubenstein JL, Maden M, Helms JA
Bone morphogenetic protein-2 (BMP-2) signaling to the Col2alpha1 gene in chondroblasts requires the homeobox gene Dlx-2.
DNA and cell biology 2001 Xu SC, Harris MA, Rubenstein JL, Mundy GR, Harris SE
Chicken Nkx6.1 expression at advanced stages of development identifies distinct brain nuclei derived from the basal plate.
Mechanisms of development 2001 Puelles E, Rubenstein JL, Puelles L
Pax-6 regulates expression of SFRP-2 and Wnt-7b in the developing CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Kim AS, Anderson SA, Rubenstein JL, Lowenstein DH, Pleasure SJ
Distinct cortical migrations from the medial and lateral ganglionic eminences.
Development (Cambridge, England) 2001 Anderson SA, Marín O, Horn C, Jennings K, Rubenstein JL
Tbr1 regulates differentiation of the preplate and layer 6.
Neuron 2001 Hevner RF, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, Bulfone A, Goffinet AM, Campagnoni AT, Rubenstein JL
Coordinate expression of Fgf8, Otx2, Bmp4, and Shh in the rostral prosencephalon during development of the telencephalic and optic vesicles.
Neuroscience 2001 Crossley PH, Martinez S, Ohkubo Y, Rubenstein JL
Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon.
Development (Cambridge, England) 2001 Yun K, Potter S, Rubenstein JL
Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons.
Neuron 2000 Pleasure SJ, Anderson S, Hevner R, Bagri A, Marin O, Lowenstein DH, Rubenstein JL
Induction and dorsoventral patterning of the telencephalon.
Neuron 2000 Wilson SW, Rubenstein JL
Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates.
Genes & development 2000 Sander M, Paydar S, Ericson J, Briscoe J, Berber E, German M, Jessell TM, Rubenstein JL
Pallial and subpallial derivatives in the embryonic chick and mouse telencephalon, traced by the expression of the genes Dlx-2, Emx-1, Nkx-2.1, Pax-6, and Tbr-1.
The Journal of comparative neurology 2000 Puelles L, Kuwana E, Puelles E, Bulfone A, Shimamura K, Keleher J, Smiga S, Rubenstein JL
Origin and molecular specification of striatal interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000 Marin O, Anderson SA, Rubenstein JL
Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1.
Development (Cambridge, England) 2000 Galceran J, Miyashita-Lin EM, Devaney E, Rubenstein JL, Grosschedl R
A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000 Zerucha T, Stühmer T, Hatch G, Park BK, Long Q, Yu G, Gambarotta A, Schultz JR, Rubenstein JL, Ekker M
Independent regulation of Dlx2 expression in the epithelium and mesenchyme of the first branchial arch.
Development (Cambridge, England) 2000 Thomas BL, Liu JK, Rubenstein JL, Sharpe PT
Intrinsic and extrinsic control of cortical development.
Novartis Foundation symposium 2000 Rubenstein JL
The contribution of the ganglionic eminence to the neuronal cell types of the cerebral cortex.
Novartis Foundation symposium 2000 Parnavelas JG, Anderson SA, Lavdas AA, Grigoriou M, Pachnis V, Rubenstein JL
Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch.
Genes & development 1999 Trumpp A, Depew MJ, Rubenstein JL, Bishop JM, Martin GR
DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation.
The Journal of comparative neurology 1999 Eisenstat DD, Liu JK, Mione M, Zhong W, Yu G, Anderson SA, Ghattas I, Puelles L, Rubenstein JL
Differential origins of neocortical projection and local circuit neurons: role of Dlx genes in neocortical interneuronogenesis.
Cerebral cortex (New York, N.Y. : 1991) 1999 Anderson S, Mione M, Yun K, Rubenstein JL
Dlx5 regulates regional development of the branchial arches and sensory capsules.
Development (Cambridge, England) 1999 Depew MJ, Liu JK, Long JE, Presley R, Meneses JJ, Pedersen RA, Rubenstein JL
Genetic control of cortical development.
Cerebral cortex (New York, N.Y. : 1991) 1999 Rubenstein JL, Rakic P
Genetic control of cortical regionalization and connectivity.
Cerebral cortex (New York, N.Y. : 1991) 1999 Rubenstein JL, Anderson S, Shi L, Miyashita-Lin E, Bulfone A, Hevner R
Early neocortical regionalization in the absence of thalamic innervation.
Science (New York, N.Y.) 1999 Miyashita-Lin EM, Hevner R, Wassarman KM, Martinez S, Rubenstein JL
Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum.
Development (Cambridge, England) 1999 Sussel L, Marin O, Kimura S, Rubenstein JL
Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and chick brain development.
Mechanisms of development 1999 Bulfone A, Martinez S, Marigo V, Campanella M, Basile A, Quaderi N, Gattuso C, Rubenstein JL, Ballabio A
Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling.
Nature 1999 Briscoe J, Sussel L, Serup P, Hartigan-O'Connor D, Jessell TM, Rubenstein JL, Ericson J
Comparison of the mammalian and avian telencephalon from the perspective of gene expression data.
European journal of morphology 1999 Puelles L, Kuwana E, Puelles E, Rubenstein JL
Cyclic nucleotide-gated cation channel expression in embryonic chick brain.
Brain research. Molecular brain research 1999 Timpe LC, Jin KL, Puelles L, Rubenstein JL
Ectopic bone morphogenetic proteins 5 and 4 in the chicken forebrain lead to cyclopia and holoprosencephaly.
Proceedings of the National Academy of Sciences of the United States of America 1999 Golden JA, Bracilovic A, McFadden KA, Beesley JS, Rubenstein JL, Grinspan JB
FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression.
Development (Cambridge, England) 1999 Martinez S, Crossley PH, Cobos I, Rubenstein JL, Martin GR
Induction of the epibranchial placodes.
Development (Cambridge, England) 1999 Begbie J, Brunet JF, Rubenstein JL, Graham A
Domains of regulatory gene expression and the developing optic chiasm: correspondence with retinal axon paths and candidate signaling cells.
The Journal of comparative neurology 1999 Marcus RC, Shimamura K, Sretavan D, Lai E, Rubenstein JL, Mason CA
An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons.
Neuron 1998 Bulfone A, Wang F, Hevner R, Anderson S, Cutforth T, Chen S, Meneses J, Pedersen R, Axel R, Rubenstein JL
Association of MSX1 and TGFB3 with nonsyndromic clefting in humans.
American journal of human genetics 1998 Lidral AC, Romitti PA, Basart AM, Doetschman T, Leysens NJ, Daack-Hirsch S, Semina EV, Johnson LR, Machida J, Burds A, Parnell TJ, Rubenstein JL, Murray JC
Development of serotonergic neurons and their projections.
Biological psychiatry 1998 Rubenstein JL
Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.
Development (Cambridge, England) 1998 Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS
FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate.
Cell 1998 Ye W, Shimamura K, Rubenstein JL, Hynes MA, Rosenthal A
Development of the cerebral cortex: V. Transcription factors and brain development.
Journal of the American Academy of Child and Adolescent Psychiatry 1998 Rubenstein JL
Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development.
Mechanisms of development 1998 Qiu M, Shimamura K, Sussel L, Chen S, Rubenstein JL
Patterning of the embryonic forebrain.
Current opinion in neurobiology 1998 Rubenstein JL, Beachy PA
Molecular control of odontogenic patterning: positional dependent initiation and morphogenesis.
European journal of oral sciences 1998 Thomas BL, Tucker AS, Ferguson C, Qiu M, Rubenstein JL, Sharpe PT
Regionalization of the prosencephalic neural plate.
Annual review of neuroscience 1998 Rubenstein JL, Shimamura K, Martinez S, Puelles L
Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation.
Developmental dynamics : an official publication of the American Association of Anatomists 1997 Liu JK, Ghattas I, Liu S, Chen S, Rubenstein JL
Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition.
Development (Cambridge, England) 1997 Thomas BL, Tucker AS, Qui M, Ferguson CA, Hardcastle Z, Rubenstein JL, Sharpe PT
Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes.
Science (New York, N.Y.) 1997 Anderson SA, Eisenstat DD, Shi L, Rubenstein JL
Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function.
Development (Cambridge, England) 1997 Wassarman KM, Lewandoski M, Campbell K, Joyner AL, Rubenstein JL, Martinez S, Martin GR
Inductive interactions direct early regionalization of the mouse forebrain.
Development (Cambridge, England) 1997 Shimamura K, Rubenstein JL
Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons.
Neuron 1997 Anderson SA, Qiu M, Bulfone A, Eisenstat DD, Meneses J, Pedersen R, Rubenstein JL
Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches.
Developmental biology 1997 Qiu M, Bulfone A, Ghattas I, Meneses JJ, Christensen L, Sharpe PT, Presley R, Pedersen RA, Rubenstein JL
ENC-1: a novel mammalian kelch-related gene specifically expressed in the nervous system encodes an actin-binding protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997 Hernandez MC, Andres-Barquin PJ, Martinez S, Bulfone A, Rubenstein JL, Israel MA
Dlx-2 homeobox gene controls neuronal differentiation in primary cultures of developing basal ganglia.
Journal of molecular neuroscience : MN 1997 Ding M, Robel L, James AJ, Eisenstat DD, Leckman JF, Rubenstein JL, Vaccarino FM
Workshop on schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America 1997 Barondes SH, Alberts BM, Andreasen NC, Bargmann C, Benes F, Goldman-Rakic P, Gottesman I, Heinemann SF, Jones EG, Kirschner M, Lewis D, Raff M, Roses A, Rubenstein J, Snyder S, Watson SJ, Weinberger …
Patterns of gene expression in the neural plate and neural tube subdivide the embryonic forebrain into transverse and longitudinal domains.
Developmental neuroscience 1997 Shimamura K, Martinez S, Puelles L, Rubenstein JL
Mutation of the Emx-1 homeobox gene disrupts the corpus callosum.
Developmental biology 1996 Qiu M, Anderson S, Chen S, Meneses JJ, Hevner R, Kuwana E, Pedersen RA, Rubenstein JL
Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus.
Genomics 1996 McGuinness T, Porteus MH, Smiga S, Bulfone A, Kingsley C, Qiu M, Liu JK, Long JE, Xu D, Rubenstein JL
The cDNA sequence of murine Nkx-2.2.
Gene 1996 Hartigan DJ, Rubenstein JL
Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome.
Molecular and cellular neurosciences 1996 Fan CM, Kuwana E, Bulfone A, Fletcher CF, Copeland NG, Jenkins NA, Crews S, Martinez S, Puelles L, Rubenstein JL, Tessier-Lavigne M
Longitudinal organization of the anterior neural plate and neural tube.
Development (Cambridge, England) 1995 Shimamura K, Hartigan DJ, Martinez S, Puelles L, Rubenstein JL
Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system.
Endocrinology 1995 Compagnone NA, Bulfone A, Rubenstein JL, Mellon SH
Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain.
Genes & development 1995 Qiu M, Bulfone A, Martinez S, Meneses JJ, Shimamura K, Pedersen RA, Rubenstein JL
T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex.
Neuron 1995 Bulfone A, Smiga SM, Shimamura K, Peterson A, Puelles L, Rubenstein JL
Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.
Endocrinology 1995 Compagnone NA, Bulfone A, Rubenstein JL, Mellon SH
Id gene expression during development and molecular cloning of the human Id-1 gene.
Brain research. Molecular brain research 1995 Zhu W, Dahmen J, Bulfone A, Rigolet M, Hernandez MC, Kuo WL, Puelles L, Rubenstein JL, Israel MA
The spatial localization of Dlx-2 during tooth development.
Connective tissue research 1995 Thomas BL, Porteus MH, Rubenstein JL, Sharpe PT
DLX-2, MASH-1, and MAP-2 expression and bromodeoxyuridine incorporation define molecularly distinct cell populations in the embryonic mouse forebrain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994 Porteus MH, Bulfone A, Liu JK, Puelles L, Lo LC, Rubenstein JL
The embryonic vertebrate forebrain: the prosomeric model.
Science (New York, N.Y.) 1994 Rubenstein JL, Martinez S, Shimamura K, Puelles L
Homeobox gene expression during development of the vertebrate brain.
Current topics in developmental biology 1994 Rubenstein JL, Puelles L
Expression patterns of homeobox and other putative regulatory genes in the embryonic mouse forebrain suggest a neuromeric organization.
Trends in neurosciences 1993 Puelles L, Rubenstein JL
Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993 Bulfone A, Puelles L, Porteus MH, Frohman MA, Martin GR, Rubenstein JL
The mouse Dlx-2 (Tes-1) gene is expressed in spatially restricted domains of the forebrain, face and limbs in midgestation mouse embryos.
Mechanisms of development 1993 Bulfone A, Kim HJ, Puelles L, Porteus MH, Grippo JF, Rubenstein JL
DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2.
Genomics 1992 Ozçelik T, Porteus MH, Rubenstein JL, Francke U
A partial cDNA sequence of the Dlx-2 cDNA.
Neuron 1992 Porteus MH, Bulfone A, Ciaranello RD, Rubenstein JL
Isolation and characterization of a library of cDNA clones that are preferentially expressed in the embryonic telencephalon.
Brain research. Molecular brain research 1992 Porteus MH, Brice AE, Bulfone A, Usdin TB, Ciaranello RD, Rubenstein JL
Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentally regulated in the ventral forebrain.
Neuron 1991 Porteus MH, Bulfone A, Ciaranello RD, Rubenstein JL
Subtractive hybridization system using single-stranded phagemids with directional inserts.
Nucleic acids research 1990 Rubenstein JL, Brice AE, Ciaranello RD, Denney D, Porteus MH, Usdin TB
Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos.
The EMBO journal 1986 Sanes JR, Rubenstein JL, Nicolas JF
Introduction of genes into preimplantation mouse embryos by use of a defective recombinant retrovirus.
Proceedings of the National Academy of Sciences of the United States of America 1986 Rubenstein JL, Nicolas JF, Jacob F
Introduction of genes into embryonal carcinoma cells and preimplantation embryos by retroviral vectors.
Cold Spring Harbor symposia on quantitative biology 1985 Nicolas JF, Rubenstein JL, Bonnerot C, Jacob F
Construction of a retrovirus capable of transducing and expressing genes in multipotential embryonic cells.
Proceedings of the National Academy of Sciences of the United States of America 1984 Rubenstein JL, Nicolas JF, Jacob F
[Nonsense RNA: a tool for specifically inhibiting the expression of a gene in vivo].
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie 1984 Rubenstein JL, Nicolas JF, Jacob F
Construction of a synthetic messenger RNA encoding a membrane protein.
The Journal of cell biology 1983 Rubenstein JL, Chappell TG
Purification of coated vesicles by agarose gel electrophoresis.
The Journal of cell biology 1981 Rubenstein JL, Fine RE, Luskey BD, Rothman JE
Lateral diffusion of M-13 coat protein in mixtures of phosphatidylcholine and cholesterol.
Biochemistry 1980 Smith LM, Rubenstein JL, Parce JW, McConnell HM
Dynamic properties of binary mixtures of phosphatidylcholines and cholesterol.
Biochemistry 1980 Rubenstein JL, Owicki JC, McConnell HM
Lateral diffusion in binary mixtures of cholesterol and phosphatidylcholines.
Proceedings of the National Academy of Sciences of the United States of America 1979 Rubenstein JL, Smith BA, McConnell HM
The mitochondrial DNA of Drosophila melanogaster exists in two distinct and stable superhelical forms.
Cell 1977 Rubenstein JL, Brutlag D, Clayton DA
Structure of hepatitis B Dane particle DNA before and after the Dane particle DNA polymerase reaction.
Journal of virology 1977 Hruska JF, Clayton DA, Rubenstein JL, Robinson WS

John Rubenstein, MD, PhDProfessorPsychiatrySchool of Medicine