John Pluvinage, MD, PhD
Resident
Neurology
School of Medicine

Awards

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• Young Physician Scientist Award, American Society for Clinical Investigation, 2026
• Career Award for Medical Scientists, Burroughs Wellcome Fund, 2025
• Henry Newman Award in Clinical Neurology, San Francisco Neurological Society, 2025
• S. Weir Mitchell Award, American Academy of Neurology, 2023

Education & Training

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• Residency Neurology UCSF 06/2025
• MD Stanford University 06/2021
• PhD Stanford University 06/2021

Websites

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• Pluvinage Lab (arcinstitute.org)

Grants and Projects

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• Autoimmune Mechanisms of Metabolic Dysfunction in the Central Nervous System, NINDS, 2025
• Mechanisms of transcobalamin receptor autoantibodies in central vitamin B12 deficiency, NINDS, 2025
• Preclinical evaluation of a therapeutic CD22 antibody in feline Niemann-Pick Type C1 disease, Ara Parseghian Medical Research Fund, 2022-2023
• Mechanisms of Age-Related Microglial Impairment and Rejuvenation in Alzheimer's Disease, NIH, 2018-2021

Publications (18)

Top publication keywords:
Neurodegenerative DiseasesHomeostasisPhagocytosisAutoantibodiesN-Acetylneuraminic AcidBrainVitamin B 12 DeficiencyAgingCentral ToleranceVitamin B 12MicrogliaCentral Nervous SystemNiemann-Pick Disease, Type CMolecular MimicrySialic Acid Binding Ig-like Lectin 2

• RNA N-glycosylation enables immune evasion and homeostatic efferocytosis.
  Nature 2025 Graziano VR, Porat J, Ah Kioon MD, Mejdrová I, Matz AJ, Lebedenko CG, Chai P, Pluvinage JV, Ricci-Azevedo R, Harrison AG, Wright SS, Wang X, Strine MS, Wang P, Wilson MR, Vanaja SK, Zhou B, Barrat FJ,…
• Permissive central tolerance plus defective peripheral checkpoints license pathogenic memory B cells in CASPR2-antibody encephalitis.
  Science advances 2025 Sun B, Fernandes D, Soltys J, Kienzler AK, Paneva S, Harrison R, Ramanathan S, Harrison AL, Makuch M, Fichtner ML, Donat RF, Akdeniz D, Bayuangga H, Im MG, Williams R, Vasconcelos A, Thomsen S, Fower …
• Permissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis.
  bioRxiv : the preprint server for biology 2025 Sun B, Fernandes D, Kienzler AK, Paneva S, Harrison R, Ramanathan S, Harrison AL, Makuch M, Fichtner ML, Donat RF, Akdeniz D, Bayuangga H, Im MG, Williams R, Vasconcelos A, Thomsen S, Fower A, Sun R, …
• Molecular mimicry in multisystem inflammatory syndrome in children.
  Nature 2024 Bodansky A, Mettelman RC, Sabatino JJ, Vazquez SE, Chou J, Novak T, Moffitt KL, Miller HS, Kung AF, Rackaityte E, Zamecnik CR, Rajan JV, Kortbawi H, Mandel-Brehm C, Mitchell A, Wang CY, Saxena A, Zorn…
• Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency.
  Science translational medicine 2024 Pluvinage JV, Ngo T, Fouassier C, McDonagh M, Holmes BB, Bartley CM, Kondapavulur S, Hurabielle C, Bodansky A, Pai V, Hinman S, Aslanpour A, Alvarenga BD, Zorn KC, Zamecnik C, McCann A, Asencor AI, …

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• MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Smith BAH, Deutzmann A, Correa KM, Delaveris CS, Dhanasekaran R, Dove CG, Sullivan DK, Wisnovsky S, Stark JC, Pluvinage JV, Swaminathan S, Riley NM, Rajan A, Majeti R, Felsher DW, Bertozzi CR
• The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C.
  Science translational medicine 2021 Pluvinage JV, Sun J, Claes C, Flynn RA, Haney MS, Iram T, Meng X, Lindemann R, Riley NM, Danhash E, Chadarevian JP, Tapp E, Gate D, Kondapavulur S, Cobos I, Chetty S, Pa?ca AM, Pa?ca SP, Berry-Kravis …
• Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.
  Nature neuroscience 2020 Marschallinger J, Iram T, Zardeneta M, Lee SE, Lehallier B, Haney MS, Pluvinage JV, Mathur V, Hahn O, Morgens DW, Kim J, Tevini J, Felder TK, Wolinski H, Bertozzi CR, Bassik MC, Aigner L, Wyss-Coray T
• Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease.
  Nature 2020 Gate D, Saligrama N, Leventhal O, Yang AC, Unger MS, Middeldorp J, Chen K, Lehallier B, Channappa D, De Los Santos MB, McBride A, Pluvinage J, Elahi F, Tam GK, Kim Y, Greicius M, Wagner AD, Aigner L, …
• Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration.
  Nature reviews. Neuroscience 2020 Pluvinage JV, Wyss-Coray T
• Single-cell analysis reveals T cell infiltration in old neurogenic niches.
  Nature 2019 Dulken BW, Buckley MT, Navarro Negredo P, Saligrama N, Cayrol R, Leeman DS, George BM, Boutet SC, Hebestreit K, Pluvinage JV, Wyss-Coray T, Weissman IL, Vogel H, Davis MM, Brunet A
• RUNX3 levels in human hematopoietic progenitors are regulated by aging and dictate erythroid-myeloid balance.
  Haematologica 2019 Balogh P, Adelman ER, Pluvinage JV, Capaldo BJ, Freeman KC, Singh S, Elagib KE, Nakamura Y, Kurita R, Sashida G, Zunder ER, Li H, Gru AA, Price EA, Schrier SL, Weissman IL, Figueroa ME, Pang WW, …
• CD22 blockade restores homeostatic microglial phagocytosis in ageing brains.
  Nature 2019 Pluvinage JV, Haney MS, Smith BAH, Sun J, Iram T, Bonanno L, Li L, Lee DP, Morgens DW, Yang AC, Shuken SR, Gate D, Scott M, Khatri P, Luo J, Bertozzi CR, Bassik MC, Wyss-Coray T
• Microglial Barriers to Viral Gene Delivery.
  Neuron 2017 Pluvinage JV, Wyss-Coray T
• Prospective isolation of human erythroid lineage-committed progenitors.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Mori Y, Chen JY, Pluvinage JV, Seita J, Weissman IL
• Osteoclast derivation from mouse bone marrow.
  Journal of visualized experiments : JoVE 2014 Tevlin R, McArdle A, Chan CK, Pluvinage J, Walmsley GG, Wearda T, Marecic O, Hu MS, Paik KJ, Senarath-Yapa K, Atashroo DA, Zielins ER, Wan DC, Weissman IL, Longaker MT
• Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Pang WW, Pluvinage JV, Price EA, Sridhar K, Arber DA, Greenberg PL, Schrier SL, Park CY, Weissman IL
• Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome.
  Blood 2011 McGowan KA, Pang WW, Bhardwaj R, Perez MG, Pluvinage JV, Glader BE, Malek R, Mendrysa SM, Weissman IL, Park CY, Barsh GS