John Newman, MD, PhD
Associate Professor
Medicine
School of Medicine

His research work as an Assistant Professor at the Buck Institute, in sunny Novato, focuses on how ketone bodies, small molecules that our bodies make for energy when we fast or exercise, also act as molecular signals to control inflammation and gene expression. The signaling functions of ketone bodies may be translational targets for protecting cognition and improving resilience in older adults. This is one example how environmental cues like diet and fasting signal through small metabolites in our cells to regulate the genes and pathways that in turn control aging. Dr. Newman is particularly interested in testing if harnessing these signals can protect older adults from the risks of hospitalization like delirium and functional decline.

Dr. Newman attends on the inpatient medicine service and the acute care of elders unit at the San Francisco VA Medical Center, with a clinical focus on delirium and functional decline. He teaches students, residents, and fellows about geriatric clinical problems, as well as about the biology of aging and emerging translational science in geriatrics. He works as a part of the national Geroscience Network to develop frameworks and resources for testing interventions that target fundamental mechanisms of aging in clinical trials. He seeks to bridge the community of basic scientists that study aging to geriatricians and other clinicians who study the clinical problems of aging in order to develop innovative translational therapies.

Dr. Newman completed an MD/PhD at the University of Washington in Seattle, then residency training in Internal Medicine and a fellowship in Geriatrics at UCSF before joining the faculty in 2014. He joined the faculty of the Buck Institute in 2018. Dr. Newman is a 2014 Beeson Scholar from the National Institute on Aging and the American Federation of Aging Research. His work has also been supported by generous funding from the Larry L. Hillblom Foundation and the Glenn Foundation for Medical Research.

Assistant Professor, Buck Institute for Research on Aging Assistant Professor, Division of Geriatrics at UCSF Geriatrician, San Francisco VA Medical Center

• Rationale and protocol for a safety, tolerability and feasibility randomized, parallel group, double-blind, placebo-controlled, pilot study of a novel ketone ester targeting frailty via immunometabolic geroscience mechanisms.
  medRxiv : the preprint server for health sciences 2023 Stubbs BJ, Alvarez-Azanedo G, Peralta S, Roa-Diaz S, Gray W, Alexander L, Silverman-Martin W, Garcia T, Blonquist TM, Upadhyay V, Turnbaugh PJ, Johnson JB, Newman JC
• β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain.
  bioRxiv : the preprint server for biology 2023 Madhavan SS, Roa Diaz S, Peralta S, Nomura M, King CD, Lin A, Bhaumik D, Shah S, Blade T, Gray W, Chamoli M, Eap B, Panda O, Diaz D, Garcia TY, Stubbs BJ, Lithgow GJ, Schilling B, Verdin E, Chaudhuri …
• Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease: JACC Scientific Statement.
  Journal of the American College of Cardiology 2023 Forman DE, Kuchel GA, Newman JC, Kirkland JL, Volpi E, Taffet GE, Barzilai N, Pandey A, Kitzman DW, Libby P, Ferrucci L
• Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Vasunilashorn SM, Lunardi N, Newman JC, Crosby G, Acker L, Abel T, Bhatnagar S, Cunningham C, de Cabo R, Dugan L, Hippensteel JA, Ishizawa Y, Lahiri S, Marcantonio ER, Xie Z, Inouye SK, Terrando N, …
• Letter to the Editor: Healthy Eating Patterns: A Stealthy Geroscience-Guided Approach to Enhancing the Human Healthspan.
  The journal of nutrition, health & aging 2023 Al-Naggar IM, Newman JC, Kuchel GA
• Longitudinal Associations between Concurrent Changes in Phenotypic Frailty and Lower Urinary Tract Symptoms among Older Men.
  The Journal of frailty & aging 2023 Bauer SR, McCulloch CE, Cawthon PM, Ensrud KE, Suskind AM, Newman JC, Harrison SL, Senders A, Covinsky K, Marshall LM
• Lower urinary tract symptom severity, urinary bother, and incident life-space mobility restriction among older men.
  Journal of the American Geriatrics Society 2022 Bauer SR, Le T, Ensrud KE, Cawthon PM, Newman JC, Suskind AM, Covinsky K, Marshall LM, Osteoporotic Fractures in Men (MrOS) Research Group
• Bis Hexanoyl (R)-1,3-Butanediol, a Novel Ketogenic Ester, Acutely Increases Circulating r- and s-ß-Hydroxybutyrate Concentrations in Healthy Adults.
  Journal of the American Nutrition Association 2022 Crabtree CD, Blade T, Hyde PN, Buga A, Kackley ML, Sapper TN, Panda O, Roa-Diaz S, Anthony JC, Newman JC, Volek JS, Stubbs BJ
• Interpreting Geroscience-Guided Biomarker Studies.
  JAMA internal medicine 2022 Bauer SR, Newman JC
• COVID-19 severity and age increase the odds of delirium in hospitalized adults with confirmed SARS-CoV-2 infection: a cohort study.
  BMC psychiatry 2022 LaHue SC, Escueta DP, Guterman EL, Patel K, Harrison KL, Boscardin WJ, Douglas VC, Newman JC
• Lower urinary tract symptoms and incident functional limitations among older community-dwelling men.
  Journal of the American Geriatrics Society 2021 Bauer SR, Cawthon PM, Ensrud KE, Suskind AM, Newman JC, Fink HA, Lu K, Scherzer R, Hoffman AR, Covinsky K, Marshall LM, Osteoporotic Fractures in Men (MrOS) Research Group
• Assessment of Frailty and Association With Progression of Benign Prostatic Hyperplasia Symptoms and Serious Adverse Events Among Men Using Drug Therapy.
  JAMA network open 2021 Bauer SR, Walter LC, Ensrud KE, Suskind AM, Newman JC, Ricke WA, Liu TT, McVary KT, Covinsky K
• Outcomes Following Implementation of a Hospital-Wide, Multicomponent Delirium Care Pathway.
  Journal of hospital medicine 2021 LaHue SC, Maselli J, Rogers S, Casatta J, Chao J, Croci R, Gonzales R, Holt B, Josephson SA, Lama S, Lau C, McCulloch C, Newman JC, Terrelonge M, Yeager J, Douglas VC
• Tolerability and Safety of a Novel Ketogenic Ester, Bis-Hexanoyl (R)-1,3-Butanediol: A Randomized Controlled Trial in Healthy Adults.
  Nutrients 2021 Chen O, Blonquist TM, Mah E, Sanoshy K, Beckman D, Nieman KM, Winters BL, Anthony JC, Verdin E, Newman JC, Stubbs BJ
• Genetic Toxicity Studies of the Ketogenic Ester Bis Hexanoyl (R)-1,3-Butanediol.
  International journal of toxicology 2021 Stubbs BJ, Nikiforov AI, Rihner MO, Weston S, Higley N, Roy S, Dakoulas E, Verdin E, Newman JC
• Toxicological evaluation of the ketogenic ester bis hexanoyl (R)-1,3-butanediol: Subchronic toxicity in Sprague Dawley rats.
  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Stubbs BJ, Nikiforov AI, Rihner MO, Weston SL, Higley N, Stump DG, Krane GA, Gadupudi G, Verdin E, Newman JC
• Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure.
  Circulation. Heart failure 2020 Yurista SR, Matsuura TR, Silljé HHW, Nijholt KT, McDaid KS, Shewale SV, Leone TC, Newman JC, Verdin E, van Veldhuisen DJ, de Boer RA, Kelly DP, Westenbrink BD
• SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease.
  Nature communications 2020 Gut P, Matilainen S, Meyer JG, Pällijeff P, Richard J, Carroll CJ, Euro L, Jackson CB, Isohanni P, Minassian BA, Alkhater RA, Østergaard E, Civiletto G, Parisi A, Thevenet J, Rardin MJ, He W, Nishida …
• In vitro stability and in vivo pharmacokinetics of the novel ketogenic ester, bis hexanoyl (R)-1,3-butanediol.
  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Stubbs BJ, Blade T, Mills S, Thomas J, Yufei X, Nelson FR, Higley N, Nikiforov AI, Rhiner MO, Verdin E, Newman JC
• From bedside to battlefield: intersection of ketone body mechanisms in geroscience with military resilience.
  GeroScience 2020 Stubbs BJ, Koutnik AP, Volek JS, Newman JC
• Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections.
  Med (New York, N.Y.) 2020 Stubbs BJ, Koutnik AP, Goldberg EL, Upadhyay V, Turnbaugh PJ, Verdin E, Newman JC
• Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells.
  Cell 2020 Ang QY, Alexander M, Newman JC, Tian Y, Cai J, Upadhyay V, Turnbaugh JA, Verdin E, Hall KD, Leibel RL, Ravussin E, Rosenbaum M, Patterson AD, Turnbaugh PJ
• Collaborative Delirium Prevention in the Age of COVID-19.
  Journal of the American Geriatrics Society 2020 LaHue SC, James TC, Newman JC, Esmaili AM, Ormseth CH, Ely EW
• Ketogenic diet and adipose tissue inflammation-a simple story? Fat chance!
  Nature metabolism 2020 Stubbs BJ, Newman JC
• From discoveries in ageing research to therapeutics for healthy ageing.
  Nature 2019 Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E
• Creating the Next Generation of Translational Geroscientists.
  Journal of the American Geriatrics Society 2019 Newman JC, Sokoloski JL, Robbins PD, Niedernhofer LJ, Reed MJ, Wei J, Austad SN, Barzilai N, Cohen HJ, Kuchel GA, Kirkland JL, Pignolo RJ
• Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series.
  Journal of the American Geriatrics Society 2019 Hurria A, Carpenter CR, McFarland F, Lundebjerg NE, de Cabo R, Ferrucci L, Studenski SA, Barzilai N, Briggs JP, Ix JH, Kitzman DW, Kuchel GA, Musi N, Newman JC, Rando TA, Smith AK, Walston JD, …
• Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet.
  Cell metabolism 2017 Tognini P, Murakami M, Liu Y, Eckel-Mahan KL, Newman JC, Verdin E, Baldi P, Sassone-Corsi P
• Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.
  Cell metabolism 2017 Newman JC, Covarrubias AJ, Zhao M, Yu X, Gut P, Ng CP, Huang Y, Haldar S, Verdin E
• β-Hydroxybutyrate: A Signaling Metabolite.
  Annual review of nutrition 2017 Newman JC, Verdin E
• Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes.
  The journals of gerontology. Series A, Biological sciences and medical sciences 2016 Justice J, Miller JD, Newman JC, Hashmi SK, Halter J, Austad SN, Barzilai N, Kirkland JL
• Strategies and Challenges in Clinical Trials Targeting Human Aging.
  The journals of gerontology. Series A, Biological sciences and medical sciences 2016 Newman JC, Milman S, Hashmi SK, Austad SN, Kirkland JL, Halter JB, Barzilai N
• Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity.
  eLife 2016 Shirakawa K, Wang L, Man N, Maksimoska J, Sorum AW, Lim HW, Lee IS, Shimazu T, Newman JC, Schröder S, Ott M, Marmorstein R, Meier J, Nimer S, Verdin E
• Dextromethorphan-Quinidine for Agitation in Alzheimer Disease.
  JAMA 2016 Newman JC, Steinman MA
• Copyright and Bedside Cognitive Testing: Why We Need Alternatives to the Mini-Mental State Examination.
  JAMA internal medicine 2015 Newman JC
• β-hydroxybutyrate: much more than a metabolite.
  Diabetes research and clinical practice 2014 Newman JC, Verdin E
• SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.
  Cell metabolism 2013 Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, Danielson SR, Guo A, Gut P, Sahu AK, Li B, Uppala R, Fitch M, Riiff T, Zhu L, Zhou J, Mulhern D, Stevens RD, Ilkayeva OR, Newgard CB, Jacobson MP, …
• Ketone bodies as signaling metabolites.
  Trends in endocrinology and metabolism: TEM 2013 Newman JC, Verdin E
• Long-term outcomes in elderly survivors of cardiac arrest.
  The New England journal of medicine 2013 Yee P, Newman J
• Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW
• Copyright at the Bedside: Should We Stop the Spread?
  Stanford Technology Law Review 2013 Feldman R, Newman J
• Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor.
  Science (New York, N.Y.) 2012 Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, de Cabo R, Ulrich S, Akassoglou K, Verdin E
• Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease.
  The Journal of biological chemistry 2012 Newman JC, He W, Verdin E
• Mitochondrial sirtuins: regulators of protein acylation and metabolism.
  Trends in endocrinology and metabolism: TEM 2012 He W, Newman JC, Wang MZ, Ho L, Verdin E
• The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.
  DNA repair 2012 Bailey AD, Gray LT, Pavelitz T, Newman JC, Horibata K, Tanaka K, Weiner AM
• Copyright and open access at the bedside.
  The New England journal of medicine 2011 Newman JC, Feldman R
• Leriche syndrome.
  Journal of general internal medicine 2010 Frederick M, Newman J, Kohlwes J
• An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome.
  PLoS genetics 2008 Newman JC, Bailey AD, Fan HY, Pavelitz T, Weiner AM
• Meta-analysis of microarray results: challenges, opportunities, and recommendations for standardization.
  Gene 2007 Cahan P, Rovegno F, Mooney D, Newman JC, St Laurent G, McCaffrey TA
• Cockayne syndrome group B protein (CSB) plays a general role in chromatin maintenance and remodeling.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Newman JC, Bailey AD, Weiner AM
• L2L: a simple tool for discovering the hidden significance in microarray expression data.
  Genome biology 2005 Newman JC, Weiner AM
• The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction.
  Molecular and cellular biology 2001 Schutzman JL, Borland CZ, Newman JC, Robinson MK, Kokel M, Stern MJ