John Kurhanewicz, PhD
Professor
Radiology
School of Medicine

He is the Director of the UCSF Body Research Interest Group, the Biomedical NMR lab, and the Kurhanewicz Laboratory at UCSF. Dr. Kurhanewicz received his BS in Chemistry from the University of South Florida/New College in 1982, and obtained his PhD in Physical Organic Chemistry from the University of South Florida, Tampa in 1987, followed by a postdoctoral fellowship in MRI/MRS from the University of California, San Francisco in 1990.

Dr. Kurhanewicz and his colleagues have developed a large prostate cancer imaging program at UCSF, involving the application of advanced magnetic resonance imaging techniques (metabolic, diffusion and perfusion weighted MRI) to provide a more accurate assessment of the extent and aggressiveness of prostate cancer in individual patients. This multiparametric 1H MRI prostate cancer staging exam is currently being used to help over a 1,000 men diagnosed with prostate cancer a year at UCSF to decide on their best therapeutic course. He is also currently involved in the development and clinical translation of an extraordinary new molecular imaging technique utilizing hyperpolarized 13C labeled metabolic substrates that has the potential to revolutionize the way MR imaging is used in the risk assessment of prostate cancer patients. He led the first clinical trial of this technology at UCSF and is involved in three ongoing clinical trials investigating its clinical utility.

Dr. Kurhanewicz has published over 230 peer-reviewed manuscripts and19 book chapters, and has been cited 16,089 times (citation indices: h-index of 69, i10-index - 180). He is a member of 7 scientific societies, serves on numerous scientific review panels for the National Institute of Health, Department of Defense and American Cancer Society and reviews for over 20 different journals. He has 25 years of mentoring in the areas of advanced MR cancer imaging and molecular imaging, and has mentored over 120 graduate and under-graduate students, medical fellows and junior faculty.

Expertise: Urology

Specialty: Prostate cancer, urology, pharmaceutical chemistry

Professional Interests: Magnetic resonance imaging, magnetic resonance spectroscopy, hyperpolarized 13C MR cancer, dynamic nuclear polarization, hyperpolarized probes, micro-imaging, diffusion tensor imaging, dynamic contrast enhanced imaging, prostate cancer, imaging biomarkers, high-resolution magic angle spinning (HR-MAS) spectroscopy, 13C and 31P spectroscopy, immunohistochemistry, gene expression, clinical translation

Education and Training:

• Bachelor of Science: University of South Florida/New College - BS, Chemistry
• Doctor of Philosophy: University of South Florida, Tampa - Physical Chemistry
• Postdoctoral Fellowship: University of California, San Francisco - Vivo MRI/MRS

• Co-Clinical Imaging Metadata Information (CIMI) for Cancer Research to Promote Open Science, Standardization, and Reproducibility in Preclinical Imaging.
  Tomography (Ann Arbor, Mich.) 2023 Moore SM, Quirk JD, Lassiter AW, Laforest R, Ayers GD, Badea CT, Fedorov AY, Kinahan PE, Holbrook M, Larson PEZ, Sriram R, Chenevert TL, Malyarenko D, Kurhanewicz J, Houghton AM, Ross BD, Pickup S, …
• Metabolite-Specific Echo Planar Imaging for Preclinical Studies with Hyperpolarized 13C-Pyruvate MRI.
  Tomography (Ann Arbor, Mich.) 2023 Sahin SI, Ji X, Agarwal S, Sinha A, Mali I, Gordon JW, Mattingly M, Subramaniam S, Kurhanewicz J, Larson PEZ, Sriram R
• Animal Models and Their Role in Imaging-Assisted Co-Clinical Trials.
  Tomography (Ann Arbor, Mich.) 2023 Peehl DM, Badea CT, Chenevert TL, Daldrup-Link HE, Ding L, Dobrolecki LE, Houghton AM, Kinahan PE, Kurhanewicz J, Lewis MT, Li S, Luker GD, Ma CX, Manning HC, Mowery YM, O'Dwyer PJ, Pautler RG, Rosen …
• Multiparametric Magnetic Resonance Imaging and Metabolic Characterization of Patient-Derived Xenograft Models of Clear Cell Renal Cell Carcinoma.
  Metabolites 2022 Agudelo JP, Upadhyay D, Zhang D, Zhao H, Nolley R, Sun J, Agarwal S, Bok RA, Vigneron DB, Brooks JD, Kurhanewicz J, Peehl DM, Sriram R
• Improving multiparametric MR-transrectal ultrasound guided fusion prostate biopsies with hyperpolarized 13 C pyruvate metabolic imaging: A technical development study.
  Magnetic resonance in medicine 2022 Chen HY, Bok RA, Cooperberg MR, Nguyen HG, Shinohara K, Westphalen AC, Wang ZJ, Ohliger MA, Gebrezgiabhier D, Carvajal L, Gordon JW, Larson PEZ, Aggarwal R, Kurhanewicz J, Vigneron DB
• Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [13 C,15 N2 ]urea + [1-13 C]pyruvate simultaneous perfusion and metabolic imaging.
  Magnetic resonance in medicine 2022 Liu X, Tang S, Mu C, Qin H, Cui D, Lai YC, Riselli AM, Delos Santos R, Carvajal L, Gebrezgiabhier D, Bok RA, Chen HY, Flavell RR, Gordon JW, Vigneron DB, Kurhanewicz J, Larson PEZ
• Hyperpolarized 1-[13C]-Pyruvate Magnetic Resonance Imaging Detects an Early Metabolic Response to Immune Checkpoint Inhibitor Therapy in Prostate Cancer.
  European urology 2021 de Kouchkovsky I, Chen HY, Ohliger MA, Wang ZJ, Bok RA, Gordon JW, Larson PEZ, Frost M, Okamoto K, Cooperberg MR, Kurhanewicz J, Vigneron DB, Aggarwal R
• Identification of prostate cancer using multiparametric MR imaging characteristics of prostate tissues referenced to whole mount histopathology.
  Magnetic resonance imaging 2021 Gibbons M, Starobinets O, Simko JP, Kurhanewicz J, Carroll PR, Noworolski SM
• Tumor metabolism and neurocognition in CNS lymphoma.
  Neuro-oncology 2021 Geng H, Tsang M, Subbaraj L, Cleveland J, Chen L, Lu M, Sharma J, Vigneron DB, Kurhanewicz J, LaFontaine M, Luks T, Barshop BA, Gangoiti J, Villanueva-Meyer JE, Rubenstein JL
• Clinical translation of hyperpolarized 13 C pyruvate and urea MRI for simultaneous metabolic and perfusion imaging.
  Magnetic resonance in medicine 2021 Qin H, Tang S, Riselli AM, Bok RA, Delos Santos R, van Criekinge M, Gordon JW, Aggarwal R, Chen R, Goddard G, Zhang CT, Chen A, Reed G, Ruscitto DM, Slater J, Sriram R, Larson PEZ, Vigneron DB, …
• Specialized computational methods for denoising, B1 correction, and kinetic modeling in hyperpolarized 13 C MR EPSI studies of liver tumors.
  Magnetic resonance in medicine 2021 Lee PM, Chen HY, Gordon JW, Zhu Z, Larson PEZ, Dwork N, Van Criekinge M, Carvajal L, Ohliger MA, Wang ZJ, Xu D, Kurhanewicz J, Bok RA, Aggarwal R, Munster PN, Vigneron DB
• Magnetic resonance biomarkers in radiation oncology: The report of AAPM Task Group 294.
  Medical physics 2021 McGee KP, Hwang KP, Sullivan DC, Kurhanewicz J, Hu Y, Wang J, Li W, Debbins J, Paulson E, Olsen JR, Hua CH, Warner L, Ma D, Moros E, Tyagi N, Chung C
• Resistance to Androgen Deprivation Leads to Altered Metabolism in Human and Murine Prostate Cancer Cell and Tumor Models.
  Metabolites 2021 Sun J, Bok RA, DeLos Santos J, Upadhyay D, DeLos Santos R, Agarwal S, Van Criekinge M, Vigneron DB, Aggarwal R, Peehl DM, Kurhanewicz J, Sriram R
• Modeling hyperpolarized lactate signal dynamics in cells, patient-derived tissue slice cultures and murine models.
  NMR in biomedicine 2021 Ahamed F, Van Criekinge M, Wang ZJ, Kurhanewicz J, Larson P, Sriram R
• False positive PSMA PET for tumor remnants in the irradiated prostate and other interpretation pitfalls in a prospective multi-center trial.
  European journal of nuclear medicine and molecular imaging 2020 Fendler WP, Calais J, Eiber M, Simko JP, Kurhanewicz J, Santos RD, Feng FY, Reiter RE, Rettig MB, Nickols NG, Kishan AU, PSMA PET Reader Group, Slavik R, Carroll PR, Lawhn-Heath C, Herrmann K, Czernin…
• Tensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized 13 C MRSI.
  Magnetic resonance in medicine 2020 Chen HY, Autry AW, Brender JR, Kishimoto S, Krishna MC, Vareth M, Bok RA, Reed GD, Carvajal L, Gordon JW, van Criekinge M, Korenchan DE, Chen AP, Xu D, Li Y, Chang SM, Kurhanewicz J, Larson PEZ, …
• Simultaneous Metabolic and Perfusion Imaging Using Hyperpolarized 13C MRI Can Evaluate Early and Dose-Dependent Response to Radiation Therapy in a Prostate Cancer Mouse Model.
  International journal of radiation oncology, biology, physics 2020 Qin H, Zhang V, Bok RA, Santos RD, Cunha JA, Hsu IC, Santos Bs JD, Lee JE, Sukumar S, Larson PEZ, Vigneron DB, Wilson DM, Sriram R, Kurhanewicz J
• Hyperpolarized 13 C MRI data acquisition and analysis in prostate and brain at University of California, San Francisco.
  NMR in biomedicine 2020 Crane JC, Gordon JW, Chen HY, Autry AW, Li Y, Olson MP, Kurhanewicz J, Vigneron DB, Larson PEZ, Xu D
• Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized 13C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures.
  Cancers 2020 Sriram R, Van Criekinge M, DeLos Santos J, Ahamed F, Qin H, Nolley R, Santos RD, Tabatabai ZL, Bok RA, Keshari KR, Vigneron DB, Peehl DM, Kurhanewicz J
• Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study.
  Prostate cancer and prostatic diseases 2019 Chen HY, Aggarwal R, Bok RA, Ohliger MA, Zhu Z, Lee P, Gordon JW, van Criekinge M, Carvajal L, Slater JB, Larson PEZ, Small EJ, Kurhanewicz J, Vigneron DB
• Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer.
  Oncotarget 2019 Korenchan DE, Bok R, Sriram R, Liu K, Santos RD, Qin H, Lobach I, Korn N, Wilson DM, Kurhanewicz J, Flavell RR
• First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism.
  Journal of magnetic resonance (San Diego, Calif. : 1997) 2019 Chung BT, Chen HY, Gordon J, Mammoli D, Sriram R, Autry AW, Le Page LM, Chaumeil MM, Shin P, Slater J, Tan CT, Suszczynski C, Chang S, Li Y, Bok RA, Ronen SM, Larson PEZ, Kurhanewicz J, Vigneron DB
• Amino Acid-Derived Sensors for Specific Zn2+ Detection Using Hyperpolarized 13 C Magnetic Resonance Spectroscopy.
  Chemistry (Weinheim an der Bergstrasse, Germany) 2019 Wang S, Korenchan DE, Perez PM, Taglang C, Hayes TR, Sriram R, Bok R, Hong AS, Wu Y, Li H, Wang Z, Kurhanewicz J, Wilson DM, Flavell RR
• Zero-field nuclear magnetic resonance of chemically exchanging systems.
  Nature communications 2019 Barskiy DA, Tayler MCD, Marco-Rius I, Kurhanewicz J, Vigneron DB, Cikrikci S, Aydogdu A, Reh M, Pravdivtsev AN, Hövener JB, Blanchard JW, Wu T, Budker D, Pines A
• Using bidirectional chemical exchange for improved hyperpolarized [13 C]bicarbonate pH imaging.
  Magnetic resonance in medicine 2019 Korenchan DE, Gordon JW, Subramaniam S, Sriram R, Baligand C, VanCriekinge M, Bok R, Vigneron DB, Wilson DM, Larson PEZ, Kurhanewicz J, Flavell RR
• Measuring Dynamic Changes in the Labile Iron Pool in Vivo with a Reactivity-Based Probe for Positron Emission Tomography.
  ACS central science 2019 Muir RK, Zhao N, Wei J, Wang YH, Moroz A, Huang Y, Chen YC, Sriram R, Kurhanewicz J, Ruggero D, Renslo AR, Evans MJ
• NMR quantification of lactate production and efflux and glutamate fractional enrichment in living human prostate biopsies cultured with [1,6-13 C2 ]glucose.
  Magnetic resonance in medicine 2019 Bancroft Brown J, Sriram R, VanCriekinge M, Delos Santos R, Sun J, Delos Santos J, Tabatabai ZL, Shinohara K, Nguyen H, Peehl DM, Kurhanewicz J
• Hyperpolarized 13C MRI: State of the Art and Future Directions.
  Radiology 2019 Wang ZJ, Ohliger MA, Larson PEZ, Gordon JW, Bok RA, Slater J, Villanueva-Meyer JE, Hess CP, Kurhanewicz J, Vigneron DB
• The Role of Lactate Metabolism in Prostate Cancer Progression and Metastases Revealed by Dual-Agent Hyperpolarized 13C MRSI.
  Cancers 2019 Bok R, Lee J, Sriram R, Keshari K, Sukumar S, Daneshmandi S, Korenchan DE, Flavell RR, Vigneron DB, Kurhanewicz J, Seth P
• Coil combination methods for multi-channel hyperpolarized 13C imaging data from human studies.
  Journal of magnetic resonance (San Diego, Calif. : 1997) 2019 Zhu Z, Zhu X, Ohliger MA, Tang S, Cao P, Carvajal L, Autry AW, Li Y, Kurhanewicz J, Chang S, Aggarwal R, Munster P, Xu D, Larson PEZ, Vigneron DB, Gordon JW
• Pulse sequence considerations for quantification of pyruvate-to-lactate conversion kPL in hyperpolarized 13 C imaging.
  NMR in biomedicine 2019 Chen HY, Gordon JW, Bok RA, Cao P, von Morze C, van Criekinge M, Milshteyn E, Carvajal L, Hurd RE, Kurhanewicz J, Vigneron DB, Larson PEZ
• Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology.
  Neoplasia (New York, N.Y.) 2018 Kurhanewicz J, Vigneron DB, Ardenkjaer-Larsen JH, Bankson JA, Brindle K, Cunningham CH, Gallagher FA, Keshari KR, Kjaer A, Laustsen C, Mankoff DA, Merritt ME, Nelson SJ, Pauly JM, Lee P, Ronen S, …
• Phase I Study of CTT1057, an 18F-Labeled Imaging Agent with Phosphoramidate Core Targeting Prostate-Specific Membrane Antigen in Prostate Cancer.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2018 Behr SC, Aggarwal R, VanBrocklin HF, Flavell RR, Gao K, Small EJ, Blecha J, Jivan S, Hope TA, Simko JP, Kurhanewicz J, Noworolski SM, Korn NJ, De Los Santos R, Cooperberg MR, Carroll PR, Nguyen HG, …
• Translation of Carbon-13 EPI for hyperpolarized MR molecular imaging of prostate and brain cancer patients.
  Magnetic resonance in medicine 2018 Gordon JW, Chen HY, Autry A, Park I, Van Criekinge M, Mammoli D, Milshteyn E, Bok R, Xu D, Li Y, Aggarwal R, Chang S, Slater JB, Ferrone M, Nelson S, Kurhanewicz J, Larson PEZ, Vigneron DB
• Dynamic diffusion-weighted hyperpolarized 13 C imaging based on a slice-selective double spin echo sequence for measurements of cellular transport.
  Magnetic resonance in medicine 2018 Zhu X, Gordon JW, Bok RA, Kurhanewicz J, Larson PEZ
• Investigation of analysis methods for hyperpolarized 13C-pyruvate metabolic MRI in prostate cancer patients.
  NMR in biomedicine 2018 Larson PEZ, Chen HY, Gordon JW, Korn N, Maidens J, Arcak M, Tang S, Criekinge M, Carvajal L, Mammoli D, Bok R, Aggarwal R, Ferrone M, Slater JB, Nelson SJ, Kurhanewicz J, Vigneron DB
• Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized 13C Pyruvate MRI.
  Cancers 2018 Sriram R, Gordon J, Baligand C, Ahamed F, Delos Santos J, Qin H, Bok RA, Vigneron DB, Kurhanewicz J, Larson PEZ, Wang ZJ
• Assessing high-intensity focused ultrasound treatment of prostate cancer with hyperpolarized 13 C dual-agent imaging of metabolism and perfusion.
  NMR in biomedicine 2018 Lee JE, Diederich CJ, Bok R, Sriram R, Santos RD, Noworolski SM, Salgaonkar VA, Adams MS, Vigneron DB, Kurhanewicz J
• Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma.
  Blood advances 2018 Rubenstein JL, Geng H, Fraser EJ, Formaker P, Chen L, Sharma J, Killea P, Choi K, Ventura J, Kurhanewicz J, Lowell C, Hwang J, Treseler P, Sneed PK, Li J, Wang X, Chen N, Gangoiti J, Munster PN, …
• Phase I study of dose escalation to dominant intraprostatic lesions using high-dose-rate brachytherapy.
  Journal of contemporary brachytherapy 2018 Chapman CH, Braunstein SE, Pouliot J, Noworolski SM, Weinberg V, Cunha A, Kurhanewicz J, Gottschalk AR, Roach MI, Hsu IC
• Spatio-Temporally Constrained Reconstruction for Hyperpolarized Carbon-13 MRI Using Kinetic Models.
  IEEE transactions on medical imaging 2018 Maidens J, Gordon JW, Chen HY, Park I, Van Criekinge M, Milshteyn E, Bok R, Aggarwal R, Ferrone M, Slater JB, Kurhanewicz J, Vigneron DB, Arcak M, Larson PEZ
• Molecular detection of inflammation in cell models using hyperpolarized 13C-pyruvate.
  Theranostics 2018 Sriram R, Nguyen J, Santos JD, Nguyen L, Sun J, Vigneron S, Van Criekinge M, Kurhanewicz J, MacKenzie JD
• Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes.
  Scientific reports 2018 Qin H, Carroll VN, Sriram R, Villanueva-Meyer JE, von Morze C, Wang ZJ, Mutch CA, Keshari KR, Flavell RR, Kurhanewicz J, Wilson DM
• Late-stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI.
  Chemical communications (Cambridge, England) 2018 Taglang C, Korenchan DE, von Morze C, Yu J, Najac C, Wang S, Blecha JE, Subramaniam S, Bok R, VanBrocklin HF, Vigneron DB, Ronen SM, Sriram R, Kurhanewicz J, Wilson DM, Flavell RR
• Measuring glucocorticoid receptor expression in vivo with PET.
  Oncotarget 2018 Truillet C, Parker MFL, Huynh LT, Wei J, Jami KM, Wang YH, Shen YS, Sriram R, Wilson DM, Kurhanewicz J, Evans MJ
• Technique development of 3D dynamic CS-EPSI for hyperpolarized 13 C pyruvate MR molecular imaging of human prostate cancer.
  Magnetic resonance in medicine 2018 Chen HY, Larson PEZ, Gordon JW, Bok RA, Ferrone M, van Criekinge M, Carvajal L, Cao P, Pauly JM, Kerr AB, Park I, Slater JB, Nelson SJ, Munster PN, Aggarwal R, Kurhanewicz J, Vigneron DB
• In vivo hyperpolarization transfer in a clinical MRI scanner.
  Magnetic resonance in medicine 2018 von Morze C, Reed GD, Larson PE, Mammoli D, Chen AP, Tropp J, Van Criekinge M, Ohliger MA, Kurhanewicz J, Vigneron DB, Merritt ME
• Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-13C]Pyruvate.
  ACS infectious diseases 2018 Sriram R, Sun J, Villanueva-Meyer J, Mutch C, De Los Santos J, Peters J, Korenchan DE, Neumann K, Van Criekinge M, Kurhanewicz J, Rosenberg O, Wilson D, Ohliger MA
• Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance in vivo.
  Scientific reports 2018 Morze CV, Allu PKR, Chang GY, Marco-Rius I, Milshteyn E, Wang ZJ, Ohliger MA, Gleason CE, Kurhanewicz J, Vigneron DB, Pearce D
• Development of methods and feasibility of using hyperpolarized carbon-13 imaging data for evaluating brain metabolism in patient studies.
  Magnetic resonance in medicine 2018 Park I, Larson PEZ, Gordon JW, Carvajal L, Chen HY, Bok R, Van Criekinge M, Ferrone M, Slater JB, Xu D, Kurhanewicz J, Vigneron DB, Chang S, Nelson SJ
• Direct assessment of renal mitochondrial redox state using hyperpolarized 13 C-acetoacetate.
  Magnetic resonance in medicine 2018 von Morze C, Ohliger MA, Marco-Rius I, Wilson DM, Flavell RR, Pearce D, Vigneron DB, Kurhanewicz J, Wang ZJ
• Sensitivity enhancement for detection of hyperpolarized 13 C MRI probes with 1 H spin coupling introduced by enzymatic transformation in vivo.
  Magnetic resonance in medicine 2017 von Morze C, Tropp J, Chen AP, Marco-Rius I, Van Criekinge M, Skloss TW, Mammoli D, Kurhanewicz J, Vigneron DB, Ohliger MA, Merritt ME
• Characterization and stratification of prostate lesions based on comprehensive multiparametric MRI using detailed whole-mount histopathology as a reference standard.
  NMR in biomedicine 2017 Starobinets O, Simko JP, Kuchinsky K, Kornak J, Carroll PR, Greene KL, Kurhanewicz J, Noworolski SM
• Impact of the integration of proton magnetic resonance imaging spectroscopy to PI-RADS 2 for prediction of high grade and high stage prostate cancer.
  Radiologia brasileira 2017 Leapman MS, Wang ZJ, Behr SC, Kurhanewicz J, Zagoria RJ, Carroll PR, Westphalen AC
• Unsaturation level decreased in bone marrow fat of postmenopausal women with low bone density using high resolution magic angle spinning (HRMAS) 1H NMR spectroscopy.
  Bone 2017 Li X, Shet K, Xu K, Rodríguez JP, Pino AM, Kurhanewicz J, Schwartz A, Rosen CJ
• Hyperpolarized 1-[13C]-Pyruvate Magnetic Resonance Imaging Detects an Early Metabolic Response to Androgen Ablation Therapy in Prostate Cancer.
  European urology 2017 Aggarwal R, Vigneron DB, Kurhanewicz J
• Cancer recurrence monitoring using hyperpolarized [1-13C]pyruvate metabolic imaging in murine breast cancer model.
  Magnetic resonance imaging 2017 Shin PJ, Zhu Z, Camarda R, Bok RA, Zhou AY, Kurhanewicz J, Goga A, Vigneron DB
• Hyperpolarized 13 C magnetic resonance evaluation of renal ischemia reperfusion injury in a murine model.
  NMR in biomedicine 2017 Baligand C, Qin H, True-Yasaki A, Gordon JW, von Morze C, Santos JD, Wilson DM, Raffai R, Cowley PM, Baker AJ, Kurhanewicz J, Lovett DH, Wang ZJ
• Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging.
  The Analyst 2017 Korenchan DE, Taglang C, von Morze C, Blecha JE, Gordon JW, Sriram R, Larson PEZ, Vigneron DB, VanBrocklin HF, Kurhanewicz J, Wilson DM, Flavell RR
• Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion.
  Cancer research 2017 Chen HY, Larson PEZ, Bok RA, von Morze C, Sriram R, Delos Santos R, Delos Santos J, Gordon JW, Bahrami N, Ferrone M, Kurhanewicz J, Vigneron DB
• Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma.
  Scientific reports 2017 Jalbert LE, Elkhaled A, Phillips JJ, Neill E, Williams A, Crane JC, Olson MP, Molinaro AM, Berger MS, Kurhanewicz J, Ronen SM, Chang SM, Nelson SJ
• Improved multiparametric MRI discrimination between low-risk prostate cancer and benign tissues in a small cohort of 5α-reductase inhibitor treated individuals as compared with an untreated cohort.
  NMR in biomedicine 2017 Starobinets O, Kurhanewicz J, Noworolski SM
• Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques.
  Magnetic resonance imaging 2017 Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Zhu Z, Chen HY, Bok R, Goga A, Kurhanewicz J, Larson PE, Vigneron DB
• Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone.
  Magnetic resonance in medicine 2016 Marco-Rius I, von Morze C, Sriram R, Cao P, Chang GY, Milshteyn E, Bok RA, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB, Merritt M
• Spectrally selective three-dimensional dynamic balanced steady-state free precession for hyperpolarized C-13 metabolic imaging with spectrally selective radiofrequency pulses.
  Magnetic resonance in medicine 2016 Shang H, Sukumar S, von Morze C, Bok RA, Marco-Rius I, Kerr A, Reed GD, Milshteyn E, Ohliger MA, Kurhanewicz J, Larson PEZ, Pauly JM, Vigneron DB
• 18F Fluorocholine Dynamic Time-of-Flight PET/MR Imaging in Patients with Newly Diagnosed Intermediate- to High-Risk Prostate Cancer: Initial Clinical-Pathologic Comparisons.
  Radiology 2016 Choi JY, Yang J, Noworolski SM, Behr S, Chang AJ, Simko JP, Nguyen HG, Carroll PR, Kurhanewicz J, Seo Y
• Separation of extra- and intracellular metabolites using hyperpolarized (13)C diffusion weighted MR.
  Journal of magnetic resonance (San Diego, Calif. : 1997) 2016 Koelsch BL, Sriram R, Keshari KR, Leon Swisher C, Van Criekinge M, Sukumar S, Vigneron DB, Wang ZJ, Larson PEZ, Kurhanewicz J
• Combining hyperpolarized 13 C MRI with a liver-specific gadolinium contrast agent for selective assessment of hepatocyte metabolism.
  Magnetic resonance in medicine 2016 Ohliger MA, von Morze C, Marco-Rius I, Gordon J, Larson PEZ, Bok R, Chen HY, Kurhanewicz J, Vigneron D
• Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry.
  Tomography (Ann Arbor, Mich.) 2016 Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB
• Practical aspects of prostate MRI: hardware and software considerations, protocols, and patient preparation.
  Abdominal radiology (New York) 2016 Starobinets O, Korn N, Iqbal S, Noworolski SM, Zagoria R, Kurhanewicz J, Westphalen AC
• Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors 13 C-lactate and 13 C-pyruvate in kidney and liver.
  Magnetic resonance in medicine 2016 von Morze C, Chang GY, Larson PE, Shang H, Allu PK, Bok RA, Crane JC, Olson MP, Tan CT, Marco-Rius I, Nelson SJ, Kurhanewicz J, Pearce D, Vigneron DB
• Multiband spectral-spatial RF excitation for hyperpolarized [2-13 C]dihydroxyacetone 13 C-MR metabolism studies.
  Magnetic resonance in medicine 2016 Marco-Rius I, Cao P, von Morze C, Merritt M, Moreno KX, Chang GY, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB
• Non-invasive differentiation of benign renal tumors from clear cell renal cell carcinomas using clinically translatable hyperpolarized 13C pyruvate magnetic resonance.
  Tomography (Ann Arbor, Mich.) 2016 Sriram R, Van Criekinge M, DeLos Santos J, Keshari KR, Wilson DM, Peehl D, Kurhanewicz J, Wang ZJ
• Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging.
  Chemical communications (Cambridge, England) 2016 Korenchan DE, Flavell RR, Baligand C, Sriram R, Neumann K, Sukumar S, VanBrocklin H, Vigneron DB, Wilson DM, Kurhanewicz J
• Caged [(18)F]FDG Glycosylamines for Imaging Acidic Tumor Microenvironments Using Positron Emission Tomography.
  Bioconjugate chemistry 2015 Flavell RR, Truillet C, Regan MK, Ganguly T, Blecha JE, Kurhanewicz J, VanBrocklin HF, Keshari KR, Chang CJ, Evans MJ, Wilson DM
• High-Resolution 3-T Endorectal Prostate MRI: A Multireader Study of Radiologist Preference and Perceived Interpretive Quality of 2D and 3D T2-Weighted Fast Spin-Echo MR Images.
  AJR. American journal of roentgenology 2015 Westphalen AC, Noworolski SM, Harisinghani M, Jhaveri KS, Raman SS, Rosenkrantz AB, Wang ZJ, Zagoria RJ, Kurhanewicz J
• Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI.
  Chemical communications (Cambridge, England) 2015 Flavell RR, von Morze C, Blecha JE, Korenchan DE, Van Criekinge M, Sriram R, Gordon JW, Chen HY, Subramaniam S, Bok RA, Wang ZJ, Vigneron DB, Larson PE, Kurhanewicz J, Wilson DM
• Real-time measurement of hyperpolarized lactate production and efflux as a biomarker of tumor aggressiveness in an MR compatible 3D cell culture bioreactor.
  NMR in biomedicine 2015 Sriram R, Van Criekinge M, Hansen A, Wang ZJ, Vigneron DB, Wilson DM, Keshari KR, Kurhanewicz J
• Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor.
  The Prostate 2015 Keshari KR, Wilson DM, Van Criekinge M, Sriram R, Koelsch BL, Wang ZJ, VanBrocklin HF, Peehl DM, O'Brien T, Sampath D, Carano RA, Kurhanewicz J
• Dynamic UltraFast 2D EXchange SpectroscopY (UF-EXSY) of hyperpolarized substrates.
  Journal of magnetic resonance (San Diego, Calif. : 1997) 2015 Leon Swisher C, Koelsch B, Sukumar S, Sriram R, Santos RD, Wang ZJ, Kurhanewicz J, Vigneron D, Larson P
• Hyperpolarized [(13)C]ketobutyrate, a molecular analog of pyruvate with modified specificity for LDH isoforms.
  Magnetic resonance in medicine 2015 von Morze C, Bok RA, Ohliger MA, Zhu Z, Vigneron DB, Kurhanewicz J
• Correlating high-resolution magic angle spinning NMR spectroscopy and gene analysis in osteoarthritic cartilage.
  NMR in biomedicine 2015 Tufts L, Shet Vishnudas K, Fu E, Kurhanewicz J, Ries M, Alliston T, Li X
• A Domain Constrained Deformable (DoCD) Model for Co-registration of Pre- and Post-Radiated Prostate MRI.
  Neurocomputing 2014 Toth R, Traughber B, Ellis R, Kurhanewicz J, Madabhushi A
• Abnormal findings on multiparametric prostate magnetic resonance imaging predict subsequent biopsy upgrade in patients with low risk prostate cancer managed with active surveillance.
  Abdominal imaging 2014 Flavell RR, Westphalen AC, Liang C, Sotto CC, Noworolski SM, Vigneron DB, Wang ZJ, Kurhanewicz J
• Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized (13) C metabolites.
  Magnetic resonance in medicine 2014 Koelsch BL, Reed GD, Keshari KR, Chaumeil MM, Bok R, Ronen SM, Vigneron DB, Kurhanewicz J, Larson PEZ
• Reduced-FOV excitation decreases susceptibility artifact in diffusion-weighted MRI with endorectal coil for prostate cancer detection.
  Magnetic resonance imaging 2014 Korn N, Kurhanewicz J, Banerjee S, Starobinets O, Saritas E, Noworolski S
• Noninvasive in vivo imaging of diabetes-induced renal oxidative stress and response to therapy using hyperpolarized 13C dehydroascorbate magnetic resonance.
  Diabetes 2014 Keshari KR, Wilson DM, Sai V, Bok R, Jen KY, Larson P, Van Criekinge M, Kurhanewicz J, Wang ZJ
• Hyperpolarized 13C MR for molecular imaging of prostate cancer.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2014 Wilson DM, Kurhanewicz J
• OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM
• Model-based feasibility assessment and evaluation of prostate hyperthermia with a commercial MR-guided endorectal HIFU ablation array.
  Medical physics 2014 Salgaonkar VA, Prakash P, Rieke V, Ozhinsky E, Plata J, Kurhanewicz J, Hsu IC, Diederich CJ
• Role of endorectal MR imaging and MR spectroscopic imaging in defining treatable intraprostatic tumor foci in prostate cancer: quantitative analysis of imaging contour compared to whole-mount histopathology.
  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2014 Anwar M, Westphalen AC, Jung AJ, Noworolski SM, Simko JP, Kurhanewicz J, Roach M, Carroll PR, Coakley FV
• The changing role of imaging in clinical care.
  Nature reviews. Urology 2014 Aggarwal R, Kurhanewicz J
• Simultaneous multiagent hyperpolarized (13)C perfusion imaging.
  Magnetic resonance in medicine 2013 von Morze C, Bok RA, Reed GD, Ardenkjaer-Larsen JH, Kurhanewicz J, Vigneron DB
• The role of magnetic resonance imaging (MRI) in focal therapy for prostate cancer: recommendations from a consensus panel.
  BJU international 2013 Muller BG, Fütterer JJ, Gupta RT, Katz A, Kirkham A, Kurhanewicz J, Moul JW, Pinto PA, Rastinehad AR, Robertson C, de la Rosette J, Sanchez-Salas R, Jones JS, Ukimura O, Verma S, Wijkstra H, Marberger…
• Cold spot mapping inferred from MRI at time of failure predicts biopsy-proven local failure after permanent seed brachytherapy in prostate cancer patients: implications for focal salvage brachytherapy.
  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2013 Crehange G, Krishnamurthy D, Cunha JA, Pickett B, Kurhanewicz J, Hsu IC, Gottschalk AR, Shinohara K, Roach M, Pouliot J
• Clinical utility of endorectal MRI-guided prostate biopsy: preliminary experience.
  Journal of magnetic resonance imaging : JMRI 2013 Jung AJ, Westphalen AC, Kurhanewicz J, Wang ZJ, Carroll PR, Simko JP, Coakley FV
• High resolution (13)C MRI with hyperpolarized urea: in vivo T(2) mapping and (15)N labeling effects.
  IEEE transactions on medical imaging 2013 Reed GD, von Morze C, Bok R, Koelsch BL, Van Criekinge M, Smith KJ, Larson PE, Kurhanewicz J, Vigneron DB
• Semiautomatic registration of digital histopathology images to in vivo MR images in molded and unmolded prostates.
  Journal of magnetic resonance imaging : JMRI 2013 Starobinets O, Guo R, Simko JP, Kuchinsky K, Kurhanewicz J, Carroll PR, Greene KL, Noworolski SM
• Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate.
  Science translational medicine 2013 Nelson SJ, Kurhanewicz J, Vigneron DB, Larson PE, Harzstark AL, Ferrone M, van Criekinge M, Chang JW, Bok R, Park I, Reed G, Carvajal L, Small EJ, Munster P, Weinberg VK, Ardenkjaer-Larsen JH, Chen AP…
• The role of metabolic imaging in radiation therapy of prostate cancer.
  NMR in biomedicine 2013 Zhang VY, Westphalen A, Delos Santos L, Tabatabai ZL, Shinohara K, Vigneron DB, Kurhanewicz J
• Endorectal MRI and MR spectroscopic imaging of prostate cancer: developing selection criteria for MR-guided focal therapy.
  Journal of magnetic resonance imaging : JMRI 2013 Chang ST, Westphalen AC, Jha P, Jung AJ, Carroll PR, Kurhanewicz J, Coakley FV
• Hyperpolarized [1-13C]dehydroascorbate MR spectroscopy in a murine model of prostate cancer: comparison with 18F-FDG PET.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013 Keshari KR, Sai V, Wang ZJ, Vanbrocklin HF, Kurhanewicz J, Wilson DM
• Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor.
  The Prostate 2013 Keshari KR, Sriram R, Van Criekinge M, Wilson DM, Wang ZJ, Vigneron DB, Peehl DM, Kurhanewicz J
• Diffusion MR of hyperpolarized 13C molecules in solution.
  The Analyst 2013 Koelsch BL, Keshari KR, Peeters TH, Larson PE, Wilson DM, Kurhanewicz J
• Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS.
  Magnetic resonance in medicine 2013 Swisher CL, Larson PE, Kruttwig K, Kerr AB, Hu S, Bok RA, Goga A, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB
• Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance Spectroscopic imaging (MRSI).
  Journal of magnetic resonance imaging : JMRI 2013 Ohliger MA, Larson PE, Bok RA, Shin P, Hu S, Tropp J, Robb F, Carvajal L, Nelson SJ, Kurhanewicz J, Vigneron DB
• Perfusion and diffusion sensitive 13C stimulated-echo MRSI for metabolic imaging of cancer.
  Magnetic resonance imaging 2012 Larson PE, Hurd RE, Kerr AB, Pauly JM, Bok RA, Kurhanewicz J, Vigneron DB
• Imaging a functional tumorigenic biomarker in the transformed epithelium.
  Proceedings of the National Academy of Sciences of the United States of America 2012 LeBeau AM, Lee M, Murphy ST, Hann BC, Warren RS, Delos Santos R, Kurhanewicz J, Hanash SM, VanBrocklin HF, Craik CS
• Multi-kernel graph embedding for detection, Gleason grading of prostate cancer via MRI/MRS.
  Medical image analysis 2012 Tiwari P, Kurhanewicz J, Madabhushi A
• Hyperpolarized 13C-pyruvate magnetic resonance reveals rapid lactate export in metastatic renal cell carcinomas.
  Cancer research 2012 Keshari KR, Sriram R, Koelsch BL, Van Criekinge M, Wilson DM, Kurhanewicz J, Wang ZJ
• Progress in prostate cancer imaging.
  Urologic oncology 2012 Gulley JL, Emberton M, Kurhanewicz J, Choyke P
• Rapid sequential injections of hyperpolarized [1-¹³C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer.
  Magnetic resonance imaging 2012 Hu S, Larson PE, Vancriekinge M, Leach AM, Park I, Leon C, Zhou J, Shin PJ, Reed G, Keselman P, von Morze C, Yoshihara H, Bok RA, Nelson SJ, Kurhanewicz J, Vigneron DB
• Frequency-specific SSFP for hyperpolarized ¹³C metabolic imaging at 14.1 T.
  Magnetic resonance imaging 2012 von Morze C, Sukumar S, Reed GD, Larson PE, Bok RA, Kurhanewicz J, Vigneron DB
• Use of hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate to probe the effects of the anticancer agent dichloroacetate on mitochondrial metabolism in vivo in the normal rat.
  Magnetic resonance imaging 2012 Hu S, Yoshihara HA, Bok R, Zhou J, Zhu M, Kurhanewicz J, Vigneron DB
• Management of prostate cancer patients with lymph node involvement: a rapidly evolving paradigm.
  Cancer treatment reviews 2012 Créhange G, Chen CP, Hsu CC, Kased N, Coakley FV, Kurhanewicz J, Roach M
• Local staging of prostate cancer: comparative accuracy of T2-weighted endorectal MR imaging and transrectal ultrasound.
  Clinical imaging 2012 Jung AJ, Coakley FV, Shinohara K, Carroll PR, Kurhanewicz J, Cowan JE, Westphalen AC
• Feasibility of MR imaging/MR spectroscopy-planned focal partial salvage permanent prostate implant (PPI) for localized recurrence after initial PPI for prostate cancer.
  International journal of radiation oncology, biology, physics 2012 Hsu CC, Hsu H, Pickett B, Crehange G, Hsu IC, Dea R, Weinberg V, Gottschalk AR, Kurhanewicz J, Shinohara K, Roach M
• Generating contrast in hyperpolarized 13C MRI using ligand-receptor interactions.
  The Analyst 2012 Keshari KR, Kurhanewicz J, Macdonald JM, Wilson DM
• Multiparametric 3T endorectal mri after external beam radiation therapy for prostate cancer.
  Journal of magnetic resonance imaging : JMRI 2012 Westphalen AC, Reed GD, Vinh PP, Sotto C, Vigneron DB, Kurhanewicz J
• Monitoring urea transport in rat kidney in vivo using hyperpolarized ¹³C magnetic resonance imaging.
  American journal of physiology. Renal physiology 2012 von Morze C, Bok RA, Sands JM, Kurhanewicz J, Vigneron DB
• A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate.
  Journal of magnetic resonance (San Diego, Calif. : 1997) 2012 Reed GD, Larson PE, Morze Cv, Bok R, Lustig M, Kerr AB, Pauly JM, Kurhanewicz J, Vigneron DB
• Does local recurrence of prostate cancer after radiation therapy occur at the site of primary tumor? Results of a longitudinal MRI and MRSI study.
  International journal of radiation oncology, biology, physics 2012 Arrayeh E, Westphalen AC, Kurhanewicz J, Roach M, Jung AJ, Carroll PR, Coakley FV
• Human prostate cancer ZIP1/zinc/citrate genetic/metabolic relationship in the TRAMP prostate cancer animal model.
  Cancer biology & therapy 2011 Costello LC, Franklin RB, Zou J, Feng P, Bok R, Swanson MG, Kurhanewicz J
• Endorectal MRI of prostate cancer: incremental prognostic importance of gross locally advanced disease.
  AJR. American journal of roentgenology 2011 Muglia VF, Westphalen AC, Wang ZJ, Kurhanewicz J, Carroll PR, Coakley FV
• Transatlantic Consensus Group on active surveillance and focal therapy for prostate cancer.
  BJU international 2011 Ahmed HU, Akin O, Coleman JA, Crane S, Emberton M, Goldenberg L, Hricak H, Kattan MW, Kurhanewicz J, Moore CM, Parker C, Polascik TJ, Scardino P, van As N, Villers A, Transatlantic Consensus Group on …
• Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Keshari KR, Kurhanewicz J, Bok R, Larson PE, Vigneron DB, Wilson DM
• Generating super stimulated-echoes in MRI and their application to hyperpolarized C-13 diffusion metabolic imaging.
  IEEE transactions on medical imaging 2011 Larson PE, Kerr AB, Reed GD, Hurd RE, Kurhanewicz J, Pauly JM, Vigneron DB
• Diagnostic tools and imaging methods in intervertebral disk degeneration.
  The Orthopedic clinics of North America 2011 Majumdar S, Link TM, Steinbach LS, Hu S, Kurhanewicz J
• Multimodal wavelet embedding representation for data combination (MaWERiC): integrating magnetic resonance imaging and spectroscopy for prostate cancer detection.
  NMR in biomedicine 2011 Tiwari P, Viswanath S, Kurhanewicz J, Sridhar A, Madabhushi A
• Prostate cancer: prediction of biochemical failure after external-beam radiation therapy--Kattan nomogram and endorectal MR imaging estimation of tumor volume.
  Radiology 2011 Westphalen AC, Koff WJ, Coakley FV, Muglia VF, Neuhaus JM, Marcus RT, Kurhanewicz J, Smith-Bindman R
• In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine.
  Magnetic resonance imaging 2011 Hu S, Zhu M, Yoshihara HA, Wilson DM, Keshari KR, Shin P, Reed G, von Morze C, Bok R, Larson PE, Kurhanewicz J, Vigneron DB
• High-resolution magic angle spinning NMR spectroscopy of human osteoarthritic cartilage.
  NMR in biomedicine 2011 Shet K, Siddiqui SM, Yoshihara H, Kurhanewicz J, Ries M, Li X
• 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression.
  Cell metabolism 2011 Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A
• Correlation of phospholipid metabolites with prostate cancer pathologic grade, proliferative status and surgical stage - impact of tissue environment.
  NMR in biomedicine 2011 Keshari KR, Tsachres H, Iman R, Delos Santos L, Tabatabai ZL, Shinohara K, Vigneron DB, Kurhanewicz J
• Magnetic resonance spectroscopic imaging of benign prostatic tissue: findings at 3.0 T compared to 1.5 T-initial experience.
  Clinical imaging 2011 Chitkara M, Westphalen A, Kurhanewicz J, Qayyum A, Poder L, Reed G, Coakley FV
• Endorectal MRI after radiation therapy: questioning the sextant analysis.
  Journal of magnetic resonance imaging : JMRI 2011 Kumbhani SR, Coakley FV, McCulloch CE, Wang ZJ, Kurhanewicz J, Roach M, Westphalen AC
• Interactive, multi-modality image registrations for combined MRI/MRSI-planned HDR prostate brachytherapy.
  Journal of contemporary brachytherapy 2011 Reed G, Cunha JA, Noworolski S, Kurhanewicz J, Vigneron D, Hsu IC, Pouliot J
• A pilot study of endorectal magnetic resonance imaging and magnetic resonance spectroscopic imaging changes with dutasteride in patients with low risk prostate cancer.
  BJU international 2011 Chung HT, Noworolski SM, Kurhanewicz J, Weinberg V, Roach Iii M
• A hydrogen peroxide-responsive hyperpolarized 13C MRI contrast agent.
  Journal of the American Chemical Society 2011 Lippert AR, Keshari KR, Kurhanewicz J, Chang CJ
• CADOnc©: An Integrated Toolkit For Evaluating Radiation Therapy Related Changes In The Prostate Using Multiparametric MRI.
  Proceedings. IEEE International Symposium on Biomedical Imaging 2011 Viswanath S, Tiwari P, Chappelow J, Toth R, Kurhanewicz J, Madabhushi A
• Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models.
  Journal of magnetic resonance imaging : JMRI 2011 von Morze C, Larson PE, Hu S, Keshari K, Wilson DM, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB
• Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.
  Neoplasia (New York, N.Y.) 2011 Kurhanewicz J, Vigneron DB, Brindle K, Chekmenev EY, Comment A, Cunningham CH, Deberardinis RJ, Green GG, Leach MO, Rajan SS, Rizi RR, Ross BD, Warren WS, Malloy CR
• A magnetic resonance spectroscopy driven initialization scheme for active shape model based prostate segmentation.
  Medical image analysis 2010 Toth R, Tiwari P, Rosen M, Reed G, Kurhanewicz J, Kalyanpur A, Pungavkar S, Madabhushi A
• Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies.
  Magnetic resonance in medicine 2010 Larson PE, Hu S, Lustig M, Kerr AB, Nelson SJ, Kurhanewicz J, Pauly JM, Vigneron DB
• Semi-parametric time-domain quantification of HR-MAS data from prostate tissue.
  NMR in biomedicine 2010 Ratiney H, Albers MJ, Rabeson H, Kurhanewicz J
• Post-processing correction of the endorectal coil reception effects in MR spectroscopic imaging of the prostate.
  Journal of magnetic resonance imaging : JMRI 2010 Noworolski SM, Reed GD, Kurhanewicz J, Vigneron DB
• Toward adaptive stereotactic robotic brachytherapy for prostate cancer: demonstration of an adaptive workflow incorporating inverse planning and an MR stealth robot.
  Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy 2010 Cunha JA, Hsu IC, Pouliot J, Roach Iii M, Shinohara K, Kurhanewicz J, Reed G, Stoianovici D
• Calculation of gestational age in late second and third trimesters by ex vivo magnetic resonance spectroscopy of amniotic fluid.
  American journal of obstetrics and gynecology 2010 Cohn BR, Fukuchi EY, Joe BN, Swanson MG, Kurhanewicz J, Yu J, Caughey AB
• Locally recurrent prostate cancer after external beam radiation therapy: diagnostic performance of 1.5-T endorectal MR imaging and MR spectroscopic imaging for detection.
  Radiology 2010 Westphalen AC, Coakley FV, Roach M, McCulloch CE, Kurhanewicz J
• Prostate MRI and 3D MR spectroscopy: how we do it.
  AJR. American journal of roentgenology 2010 Verma S, Rajesh A, Fütterer JJ, Turkbey B, Scheenen TW, Pang Y, Choyke PL, Kurhanewicz J
• Prostate cancer managed with active surveillance: role of anatomic MR imaging and MR spectroscopic imaging.
  Radiology 2010 Fradet V, Kurhanewicz J, Cowan JE, Karl A, Coakley FV, Shinohara K, Carroll PR
• Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate.
  Magnetic resonance in medicine 2010 Hurd RE, Yen YF, Mayer D, Chen A, Wilson D, Kohler S, Bok R, Vigneron D, Kurhanewicz J, Tropp J, Spielman D, Pfefferbaum A
• Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo.
  Journal of magnetic resonance (San Diego, Calif. : 1997) 2010 Wilson DM, Keshari KR, Larson PE, Chen AP, Hu S, Van Criekinge M, Bok R, Nelson SJ, Macdonald JM, Vigneron DB, Kurhanewicz J
• Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI.
  Magnetic resonance in medicine 2010 Larson PE, Bok R, Kerr AB, Lustig M, Hu S, Chen AP, Nelson SJ, Pauly JM, Kurhanewicz J, Vigneron DB
• Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy.
  Cancer research 2010 Ward CS, Venkatesh HS, Chaumeil MM, Brandes AH, Vancriekinge M, Dafni H, Sukumar S, Nelson SJ, Vigneron DB, Kurhanewicz J, James CD, Haas-Kogan DA, Ronen SM
• A novel application of 1H magnetic resonance spectroscopy: non-invasive identification of spermatogenesis in men with non-obstructive azoospermia.
  Human reproduction (Oxford, England) 2010 Aaronson DS, Iman R, Walsh TJ, Kurhanewicz J, Turek PJ
• 3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer.
  Magnetic resonance in medicine 2010 Hu S, Lustig M, Balakrishnan A, Larson PE, Bok R, Kurhanewicz J, Nelson SJ, Goga A, Pauly JM, Vigneron DB
• Hyperpolarized (13)C spectroscopy and an NMR-compatible bioreactor system for the investigation of real-time cellular metabolism.
  Magnetic resonance in medicine 2010 Keshari KR, Kurhanewicz J, Jeffries RE, Wilson DM, Dewar BJ, Van Criekinge M, Zierhut M, Vigneron DB, Macdonald JM
• Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors.
  Neuro-oncology 2010 Park I, Larson PE, Zierhut ML, Hu S, Bok R, Ozawa T, Kurhanewicz J, Vigneron DB, Vandenberg SR, James CD, Nelson SJ
• Semi supervised multi kernel (SeSMiK) graph embedding: identifying aggressive prostate cancer via magnetic resonance imaging and spectroscopy.
  Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention 2010 Tiwari P, Kurhanewicz J, Rosen M, Madabhushi A
• Metabolic, pathologic, and genetic analysis of prostate tissues: quantitative evaluation of histopathologic and mRNA integrity after HR-MAS spectroscopy.
  NMR in biomedicine 2009 Santos CF, Kurhanewicz J, Tabatabai ZL, Simko JP, Keshari KR, Gbegnon A, Santos RD, Federman S, Shinohara K, Carroll PR, Haqq CM, Swanson MG
• Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging.
  Journal of the American Chemical Society 2009 Keshari KR, Wilson DM, Chen AP, Bok R, Larson PE, Hu S, Van Criekinge M, Macdonald JM, Vigneron DB, Kurhanewicz J
• Assessment of intervertebral disc degeneration with magnetic resonance single-voxel spectroscopy.
  Magnetic resonance in medicine 2009 Zuo J, Saadat E, Romero A, Loo K, Li X, Link TM, Kurhanewicz J, Majumdar S
• Methods for metabolic evaluation of prostate cancer cells using proton and (13)C HR-MAS spectroscopy and [3-(13)C] pyruvate as a metabolic substrate.
  Magnetic resonance in medicine 2009 Levin YS, Albers MJ, Butler TN, Spielman D, Peehl DM, Kurhanewicz J
• Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice.
  Journal of magnetic resonance (San Diego, Calif. : 1997) 2009 Zierhut ML, Yen YF, Chen AP, Bok R, Albers MJ, Zhang V, Tropp J, Park I, Vigneron DB, Kurhanewicz J, Hurd RE, Nelson SJ
• Quantitative metabolic profiles of 2nd and 3rd trimester human amniotic fluid using (1)H HR-MAS spectroscopy.
  Magma (New York, N.Y.) 2009 Cohn BR, Joe BN, Zhao S, Kornak J, Zhang VY, Iman R, Kurhanewicz J, Vahidi K, Yu J, Caughey AB, Swanson MG
• Mucinous adenocarcinoma of the prostate: MRI and MR spectroscopy features.
  AJR. American journal of roentgenology 2009 Westphalen AC, Coakley FV, Kurhanewicz J, Reed G, Wang ZJ, Simko JP
• Analysis of hyperpolarized dynamic 13C lactate imaging in a transgenic mouse model of prostate cancer.
  Magnetic resonance imaging 2009 Lupo JM, Chen AP, Zierhut ML, Bok RA, Cunningham CH, Kurhanewicz J, Vigneron DB, Nelson SJ
• Imaging considerations for in vivo 13C metabolic mapping using hyperpolarized 13C-pyruvate.
  Magnetic resonance in medicine 2009 Yen YF, Kohler SJ, Chen AP, Tropp J, Bok R, Wolber J, Albers MJ, Gram KA, Zierhut ML, Park I, Zhang V, Hu S, Nelson SJ, Vigneron DB, Kurhanewicz J, Dirven HA, Hurd RE
• In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate.
  Molecular imaging and biology 2009 Hu S, Chen AP, Zierhut ML, Bok R, Yen YF, Schroeder MA, Hurd RE, Nelson SJ, Kurhanewicz J, Vigneron DB
• Prostate cancer: sextant localization at MR imaging and MR spectroscopic imaging before prostatectomy--results of ACRIN prospective multi-institutional clinicopathologic study.
  Radiology 2009 Weinreb JC, Blume JD, Coakley FV, Wheeler TM, Cormack JB, Sotto CK, Cho H, Kawashima A, Tempany-Afdhal CM, Macura KJ, Rosen M, Gerst SR, Kurhanewicz J
• Generation of hyperpolarized substrates by secondary labeling with [1,1-13C] acetic anhydride.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Wilson DM, Hurd RE, Keshari K, Van Criekinge M, Chen AP, Nelson SJ, Vigneron DB, Kurhanewicz J
• Evaluation of the ERETIC method as an improved quantitative reference for 1H HR-MAS spectroscopy of prostate tissue.
  Magnetic resonance in medicine 2009 Albers MJ, Butler TN, Rahwa I, Bao N, Keshari KR, Swanson MG, Kurhanewicz J
• T2-Weighted endorectal magnetic resonance imaging of prostate cancer after external beam radiation therapy.
  International braz j urol : official journal of the Brazilian Society of Urology 2009 Westphalen AC, Kurhanewicz J, Cunha RM, Hsu IC, Kornak J, Zhao S, Coakley FV
• Spectral embedding based probabilistic boosting tree (ScEPTre): classifying high dimensional heterogeneous biomedical data.
  Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention 2009 Tiwari P, Rosen M, Reed G, Kurhanewicz J, Madabhushi A
• In vivo hyperpolarized 13C MR spectroscopic imaging with 1H decoupling.
  Journal of magnetic resonance (San Diego, Calif. : 1997) 2008 Chen AP, Tropp J, Hurd RE, Van Criekinge M, Carvajal LG, Xu D, Kurhanewicz J, Vigneron DB
• (1)H HR-MAS spectroscopy for quantitative measurement of choline concentration in amniotic fluid as a marker of fetal lung maturity: inter- and intraobserver reproducibility study.
  Journal of magnetic resonance imaging : JMRI 2008 Joe BN, Vahidi K, Zektzer A, Chen MH, Clifton MS, Butler T, Keshari K, Kurhanewicz J, Coakley F, Swanson MG
• Advances in MR spectroscopy of the prostate.
  Magnetic resonance imaging clinics of North America 2008 Kurhanewicz J, Vigneron DB
• Combined magnetic resonance imaging and magnetic resonance spectroscopy imaging in the diagnosis of prostate cancer: a systematic review and meta-analysis.
  European urology 2008 Umbehr M, Bachmann LM, Held U, Kessler TM, Sulser T, Weishaupt D, Kurhanewicz J, Steurer J
• Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
  Cancer research 2008 Albers MJ, Bok R, Chen AP, Cunningham CH, Zierhut ML, Zhang VY, Kohler SJ, Tropp J, Hurd RE, Yen YF, Nelson SJ, Vigneron DB, Kurhanewicz J
• In vivo (1)H magnetic resonance spectroscopy of amniotic fluid and fetal lung at 1.5 T: technical challenges.
  Journal of magnetic resonance imaging : JMRI 2008 Kim DH, Vahidi K, Caughey AB, Coakley FV, Vigneron DB, Kurhanewicz J, Mow B, Joe BN
• Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR-MAS spectroscopy of biopsy tissues.
  Magnetic resonance in medicine 2008 Tessem MB, Swanson MG, Keshari KR, Albers MJ, Joun D, Tabatabai ZL, Simko JP, Shinohara K, Nelson SJ, Vigneron DB, Gribbestad IS, Kurhanewicz J
• Pretreatment endorectal magnetic resonance imaging and magnetic resonance spectroscopic imaging features of prostate cancer as predictors of response to external beam radiotherapy.
  International journal of radiation oncology, biology, physics 2008 Joseph T, McKenna DA, Westphalen AC, Coakley FV, Zhao S, Lu Y, Hsu IC, Roach M, Kurhanewicz J
• Quantification of choline- and ethanolamine-containing metabolites in human prostate tissues using 1H HR-MAS total correlation spectroscopy.
  Magnetic resonance in medicine 2008 Swanson MG, Keshari KR, Tabatabai ZL, Simko JP, Shinohara K, Carroll PR, Zektzer AS, Kurhanewicz J
• Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging.
  Journal of magnetic resonance (San Diego, Calif. : 1997) 2008 Larson PE, Kerr AB, Chen AP, Lustig MS, Zierhut ML, Hu S, Cunningham CH, Pauly JM, Kurhanewicz J, Vigneron DB
• Dynamic contrast-enhanced MRI and MR diffusion imaging to distinguish between glandular and stromal prostatic tissues.
  Magnetic resonance imaging 2008 Noworolski SM, Vigneron DB, Chen AP, Kurhanewicz J
• Feasibility of using hyperpolarized [1-13C]lactate as a substrate for in vivo metabolic 13C MRSI studies.
  Magnetic resonance imaging 2008 Chen AP, Kurhanewicz J, Bok R, Xu D, Joun D, Zhang V, Nelson SJ, Hurd RE, Vigneron DB
• A clinical comparison of rigid and inflatable endorectal-coil probes for MRI and 3D MR spectroscopic imaging (MRSI) of the prostate.
  Journal of magnetic resonance imaging : JMRI 2008 Noworolski SM, Crane JC, Vigneron DB, Kurhanewicz J
• Prostate cancer: is inapparent tumor at endorectal MR and MR spectroscopic imaging a favorable prognostic finding in patients who select active surveillance?
  Radiology 2008 Cabrera AR, Coakley FV, Westphalen AC, Lu Y, Zhao S, Shinohara K, Carroll PR, Kurhanewicz J
• Role of magnetic resonance imaging and magnetic resonance spectroscopic imaging before and after radiotherapy for prostate cancer.
  Journal of endourology 2008 Westphalen AC, McKenna DA, Kurhanewicz J, Coakley FV
• Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products.
  Journal of magnetic resonance (San Diego, Calif. : 1997) 2008 Cunningham CH, Chen AP, Lustig M, Hargreaves BA, Lupo J, Xu D, Kurhanewicz J, Hurd RE, Pauly JM, Nelson SJ, Vigneron DB
• Compressed sensing for resolution enhancement of hyperpolarized 13C flyback 3D-MRSI.
  Journal of magnetic resonance (San Diego, Calif. : 1997) 2008 Hu S, Lustig M, Chen AP, Crane J, Kerr A, Kelley DA, Hurd R, Kurhanewicz J, Nelson SJ, Pauly JM, Vigneron DB
• Current and potential applications of clinical 13C MR spectroscopy.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008 Kurhanewicz J, Bok R, Nelson SJ, Vigneron DB
• Class solution in inverse planned HDR prostate brachytherapy for dose escalation of DIL defined by combined MRI/MRSI.
  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2008 Kim Y, Hsu IC, Lessard E, Kurhanewicz J, Noworolski SM, Pouliot J
• Prostate cancer: role of pretreatment MR in predicting outcome after external-beam radiation therapy--initial experience.
  Radiology 2008 McKenna DA, Coakley FV, Westphalen AC, Zhao S, Lu Y, Webb EM, Pickett B, Roach M, Kurhanewicz J
• Lactic acid and proteoglycans as metabolic markers for discogenic back pain.
  Spine 2008 Keshari KR, Lotz JC, Link TM, Hu S, Majumdar S, Kurhanewicz J
• DNP-Hyperpolarized C Magnetic Resonance Metabolic Imaging for Cancer Applications.
  Applied magnetic resonance 2008 Nelson SJ, Vigneron D, Kurhanewicz J, Chen A, Bok R, Hurd R
• Multiparametric magnetic resonance imaging in prostate cancer: present and future.
  Current opinion in urology 2008 Kurhanewicz J, Vigneron D, Carroll P, Coakley F
• Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience.
  Magnetic resonance in medicine 2007 Chen AP, Albers MJ, Cunningham CH, Kohler SJ, Yen YF, Hurd RE, Tropp J, Bok R, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB
• Peripheral zone prostate cancer: accuracy of different interpretative approaches with MR and MR spectroscopic imaging.
  Radiology 2007 Westphalen AC, Coakley FV, Qayyum A, Swanson M, Simko JP, Lu Y, Zhao S, Carroll PR, Yeh BM, Kurhanewicz J
• Prostate cancer: sextant localization with MR imaging, MR spectroscopy, and 11C-choline PET/CT.
  Radiology 2007 Testa C, Schiavina R, Lodi R, Salizzoni E, Corti B, Farsad M, Kurhanewicz J, Manferrari F, Brunocilla E, Tonon C, Monetti N, Castellucci P, Fanti S, Coe M, Grigioni WF, Martorana G, Canini R, …
• 3D MR spectroscopic imaging in the evaluation of prostate cancer.
  Clinical radiology 2007 Rajesh A, Coakley FV, Kurhanewicz J
• In vivo 13 carbon metabolic imaging at 3T with hyperpolarized 13C-1-pyruvate.
  Magnetic resonance in medicine 2007 Kohler SJ, Yen Y, Wolber J, Chen AP, Albers MJ, Bok R, Zhang V, Tropp J, Nelson S, Vigneron DB, Kurhanewicz J, Hurd RE
• Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C.
  Journal of magnetic resonance (San Diego, Calif. : 1997) 2007 Cunningham CH, Chen AP, Albers MJ, Kurhanewicz J, Hurd RE, Yen YF, Pauly JM, Nelson SJ, Vigneron DB
• High-speed 3T MR spectroscopic imaging of prostate with flyback echo-planar encoding.
  Journal of magnetic resonance imaging : JMRI 2007 Chen AP, Cunningham CH, Ozturk-Isik E, Xu D, Hurd RE, Kelley DA, Pauly JM, Kurhanewicz J, Nelson SJ, Vigneron DB
• Diagnosis of prostate cancer in patients with an elevated prostate-specific antigen level: role of endorectal MRI and MR spectroscopic imaging.
  AJR. American journal of roentgenology 2007 Costouros NG, Coakley FV, Westphalen AC, Qayyum A, Yeh BM, Joe BN, Kurhanewicz J
• Validity of prostate-specific antigen as a tumour marker in men with prostate cancer managed by watchful-waiting: correlation with findings at serial endorectal magnetic resonance imaging and spectroscopic imaging.
  BJU international 2007 Coakley FV, Chen I, Qayyum A, Westphalen AC, Carroll PR, Hricak H, Chen MH, Kurhanewicz J
• High-grade prostatic intraepithelial neoplasia in patients with prostate cancer: MR and MR spectroscopic imaging features--initial experience.
  Radiology 2006 Hom JJ, Coakley FV, Simko JP, Lu Y, Qayyum A, Westphalen AC, Schmitt LD, Carroll PR, Kurhanewicz J
• Magnetic resonance spectroscopy in patients with locally confined prostate cancer: association of prostatic citrate and metabolic atrophy with time on hormone deprivation therapy, PSA level, and biopsy Gleason score.
  European radiology 2006 Mueller-Lisse UG, Swanson MG, Vigneron DB, Kurhanewicz J
• Quantitative analysis of prostate metabolites using 1H HR-MAS spectroscopy.
  Magnetic resonance in medicine 2006 Swanson MG, Zektzer AS, Tabatabai ZL, Simko J, Jarso S, Keshari KR, Schmitt L, Carroll PR, Shinohara K, Vigneron DB, Kurhanewicz J
• High-resolution 3D MR spectroscopic imaging of the prostate at 3 T with the MLEV-PRESS sequence.
  Magnetic resonance imaging 2006 Chen AP, Cunningham CH, Kurhanewicz J, Xu D, Hurd RE, Pauly JM, Carvajal L, Karpodinis K, Vigneron DB
• Feasibility of magnetic resonance spectroscopy for evaluating fetal lung maturity.
  Journal of pediatric surgery 2006 Clifton MS, Joe BN, Zektzer AS, Kurhanewicz J, Vigneron DB, Coakley FV, Nobuhara KK, Swanson MG
• Quantification of prostate MRSI data by model-based time domain fitting and frequency domain analysis.
  NMR in biomedicine 2006 Pels P, Ozturk-Isik E, Swanson MG, Vanhamme L, Kurhanewicz J, Nelson SJ, Van Huffel S
• Three-dimensional conformal external beam radiotherapy compared with permanent prostate implantation in low-risk prostate cancer based on endorectal magnetic resonance spectroscopy imaging and prostate-specific antigen level.
  International journal of radiation oncology, biology, physics 2006 Pickett B, Kurhanewicz J, Pouliot J, Weinberg V, Shinohara K, Coakley F, Roach M
• Registration of MR prostate images with biomechanical modeling and nonlinear parameter estimation.
  Medical physics 2006 Alterovitz R, Goldberg K, Pouliot J, Hsu IC, Kim Y, Noworolski SM, Kurhanewicz J
• Magnetic resonance imaging and spectroscopy of prostate cancer.
  Reviews in urology 2006 Carroll PR, Coakley FV, Kurhanewicz J
• Prostate cancer: endorectal MR imaging and MR spectroscopic imaging--distinction of true-positive results from chance-detected lesions.
  Radiology 2006 Hom JJ, Coakley FV, Simko JP, Qayyum A, Lu Y, Schmitt L, Carroll PR, Kurhanewicz J
• Correlation of HR-MAS spectroscopy derived metabolite concentrations with collagen and proteoglycan levels and Thompson grade in the degenerative disc.
  Spine 2005 Keshari KR, Lotz JC, Kurhanewicz J, Majumdar S
• Expandable and rigid endorectal coils for prostate MRI: impact on prostate distortion and rigid image registration.
  Medical physics 2005 Kim Y, Hsu IC, Pouliot J, Noworolski SM, Vigneron DB, Kurhanewicz J
• Prostatic biopsy directed with endorectal MR spectroscopic imaging findings in patients with elevated prostate specific antigen levels and prior negative biopsy findings: early experience.
  Radiology 2005 Prando A, Kurhanewicz J, Borges AP, Oliveira EM, Figueiredo E
• Sequence design for magnetic resonance spectroscopic imaging of prostate cancer at 3 T.
  Magnetic resonance in medicine 2005 Cunningham CH, Vigneron DB, Marjanska M, Chen AP, Xu D, Hurd RE, Kurhanewicz J, Garwood M, Pauly JM
• Characterization of intervertebral disc degeneration by high-resolution magic angle spinning (HR-MAS) spectroscopy.
  Magnetic resonance in medicine 2005 Keshari KR, Zektzer AS, Swanson MG, Majumdar S, Lotz JC, Kurhanewicz J
• Dynamic contrast-enhanced MRI in normal and abnormal prostate tissues as defined by biopsy, MRI, and 3D MRSI.
  Magnetic resonance in medicine 2005 Noworolski SM, Henry RG, Vigneron DB, Kurhanewicz J
• Improved signal to noise in high-resolution magic angle spinning total correlation spectroscopy studies of prostate tissues using rotor-synchronized adiabatic pulses.
  Magnetic resonance in medicine 2005 Zektzer AS, Swanson MG, Jarso S, Nelson SJ, Vigneron DB, Kurhanewicz J
• Preliminary assessment of magnetic resonance spectroscopic imaging in predicting treatment outcome in patients with prostate cancer at high risk for relapse.
  Clinical prostate cancer 2004 Pucar D, Koutcher JA, Shah A, Dyke JP, Schwartz L, Thaler H, Kurhanewicz J, Scardino PT, Kelly WK, Hricak H, Zakian KL
• Prostate depiction at endorectal MR spectroscopic imaging: investigation of a standardized evaluation system.
  Radiology 2004 Jung JA, Coakley FV, Vigneron DB, Swanson MG, Qayyum A, Weinberg V, Jones KD, Carroll PR, Kurhanewicz J
• Use of MRI and spectroscopy in evaluation of external beam radiotherapy for prostate cancer.
  International journal of radiation oncology, biology, physics 2004 Pickett B, Kurhanewicz J, Coakley F, Shinohara K, Fein B, Roach M
• Organ-confined prostate cancer: effect of prior transrectal biopsy on endorectal MRI and MR spectroscopic imaging.
  AJR. American journal of roentgenology 2004 Qayyum A, Coakley FV, Lu Y, Olpin JD, Wu L, Yeh BM, Carroll PR, Kurhanewicz J
• Endorectal MR imaging and MR spectroscopic imaging for locally recurrent prostate cancer after external beam radiation therapy: preliminary experience.
  Radiology 2004 Coakley FV, Teh HS, Qayyum A, Swanson MG, Lu Y, Roach M, Pickett B, Shinohara K, Vigneron DB, Kurhanewicz J
• Inverse planning for HDR prostate brachytherapy used to boost dominant intraprostatic lesions defined by magnetic resonance spectroscopy imaging.
  International journal of radiation oncology, biology, physics 2004 Pouliot J, Kim Y, Lessard E, Hsu IC, Vigneron DB, Kurhanewicz J
• Time to metabolic atrophy after permanent prostate seed implantation based on magnetic resonance spectroscopic imaging.
  International journal of radiation oncology, biology, physics 2004 Pickett B, Ten Haken RK, Kurhanewicz J, Qayyum A, Shinohara K, Fein B, Roach M
• Image registration for prostate MR spectroscopy using modeling and optimization of force and stiffness parameters.
  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2004 Alterovitz R, Goldberg K, Kurhanewicz J, Pouliot J, Hsu IC
• Prostate cancer localization with endorectal MR imaging and MR spectroscopic imaging: effect of clinical data on reader accuracy.
  Radiology 2004 Dhingsa R, Qayyum A, Coakley FV, Lu Y, Jones KD, Swanson MG, Carroll PR, Hricak H, Kurhanewicz J
• Magnetic resonance imaging and spectroscopic imaging of prostate cancer.
  The Journal of urology 2003 Coakley FV, Qayyum A, Kurhanewicz J
• Proton HR-MAS spectroscopy and quantitative pathologic analysis of MRI/3D-MRSI-targeted postsurgical prostate tissues.
  Magnetic resonance in medicine 2003 Swanson MG, Vigneron DB, Tabatabai ZL, Males RG, Schmitt L, Carroll PR, James JK, Hurd RE, Kurhanewicz J
• Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cells.
  The Journal of biological chemistry 2003 Zhao YG, Xiao AZ, Newcomer RG, Park HI, Kang T, Chung LW, Swanson MG, Zhau HE, Kurhanewicz J, Sang QX
• Prostate cancer tumor volume: measurement with endorectal MR and MR spectroscopic imaging.
  Radiology 2002 Coakley FV, Kurhanewicz J, Lu Y, Jones KD, Swanson MG, Chang SD, Carroll PR, Hricak H
• Dualband spectral-spatial RF pulses for prostate MR spectroscopic imaging.
  Magnetic resonance in medicine 2001 Schricker AA, Pauly JM, Kurhanewicz J, Swanson MG, Vigneron DB
• Spectroscopy in prostate cancer: hope or hype?
  Oncology (Williston Park, N.Y.) 2001 Roach M, Kurhanewicz J, Carroll P
• Time-dependent effects of hormone-deprivation therapy on prostate metabolism as detected by combined magnetic resonance imaging and 3D magnetic resonance spectroscopic imaging.
  Magnetic resonance in medicine 2001 Mueller-Lisse UG, Swanson MG, Vigneron DB, Hricak H, Bessette A, Males RG, Wood PJ, Noworolski S, Nelson SJ, Barken I, Carroll PR, Kurhanewicz J
• Brachytherapy for prostate cancer: endorectal MR imaging of local treatment-related changes.
  Radiology 2001 Coakley FV, Hricak H, Wefer AE, Speight JL, Kurhanewicz J, Roach M
• Magnetic resonance imaging and spectroscopic imaging: Improved patient selection and potential for metabolic intermediate endpoints in prostate cancer chemoprevention trials.
  Urology 2001 Kurhanewicz J, Swanson MG, Wood PJ, Vigneron DB
• Magnetic resonance imaging and spectroscopic imaging of prostate cancer.
  Cancer investigation 2001 Swanson MG, Vigneron DB, Tran TK, Kurhanewicz J
• Sextant localization of prostate cancer: comparison of sextant biopsy, magnetic resonance imaging and magnetic resonance spectroscopic imaging with step section histology.
  The Journal of urology 2000 Wefer AE, Hricak H, Vigneron DB, Coakley FV, Lu Y, Wefer J, Mueller-Lisse U, Carroll PR, Kurhanewicz J
• Clinical application of BASING and spectral/spatial water and lipid suppression pulses for prostate cancer staging and localization by in vivo 3D 1H magnetic resonance spectroscopic imaging.
  Magnetic resonance in medicine 2000 Males RG, Vigneron DB, Star-Lack J, Falbo SC, Nelson SJ, Hricak H, Kurhanewicz J
• The prostate: MR imaging and spectroscopy. Present and future.
  Radiologic clinics of North America 2000 Kurhanewicz J, Vigneron DB, Males RG, Swanson MG, Yu KK, Hricak H
• Three-dimensional magnetic resonance spectroscopic imaging of brain and prostate cancer.
  Neoplasia (New York, N.Y.) 2000 Kurhanewicz J, Vigneron DB, Nelson SJ
• Very selective suppression pulses for clinical MRSI studies of brain and prostate cancer.
  Magnetic resonance in medicine 2000 Tran TK, Vigneron DB, Sailasuta N, Tropp J, Le Roux P, Kurhanewicz J, Nelson S, Hurd R
• Prostate cancer: localization with three-dimensional proton MR spectroscopic imaging--clinicopathologic study.
  Radiology 1999 Scheidler J, Hricak H, Vigneron DB, Yu KK, Sokolov DL, Huang LR, Zaloudek CJ, Nelson SJ, Carroll PR, Kurhanewicz J
• Prostate cancer: prediction of extracapsular extension with endorectal MR imaging and three-dimensional proton MR spectroscopic imaging.
  Radiology 1999 Yu KK, Scheidler J, Hricak H, Vigneron DB, Zaloudek CJ, Males RG, Nelson SJ, Carroll PR, Kurhanewicz J
• Static field intensity modulation to treat a dominant intra-prostatic lesion to 90 Gy compared to seven field 3-dimensional radiotherapy.
  International journal of radiation oncology, biology, physics 1999 Pickett B, Vigneault E, Kurhanewicz J, Verhey L, Roach M
• In vivo lactate editing with simultaneous detection of choline, creatine, NAA, and lipid singlets at 1.5 T using PRESS excitation with applications to the study of brain and head and neck tumors.
  Journal of magnetic resonance (San Diego, Calif. : 1997) 1998 Star-Lack J, Spielman D, Adalsteinsson E, Kurhanewicz J, Terris DJ, Vigneron DB
• Detection of recurrent prostate cancer after cryosurgery.
  Current opinion in urology 1998 Parivar F, Kurhanewicz J
• Localizing prostate cancer in the presence of postbiopsy changes on MR images: role of proton MR spectroscopic imaging.
  Radiology 1998 Kaji Y, Kurhanewicz J, Hricak H, Sokolov DL, Huang LR, Nelson SJ, Vigneron DB
• High spatial resolution and speed in MRSI.
  NMR in biomedicine 1997 Nelson SJ, Vigneron DB, Star-Lack J, Kurhanewicz J
• Improved water and lipid suppression for 3D PRESS CSI using RF band selective inversion with gradient dephasing (BASING).
  Magnetic resonance in medicine 1997 Star-Lack J, Nelson SJ, Kurhanewicz J, Huang LR, Vigneron DB
• Improved solvent suppression and increased spatial excitation bandwidths for three-dimensional PRESS CSI using phase-compensating spectral/spatial spin-echo pulses.
  Journal of magnetic resonance imaging : JMRI 1997 Star-Lack J, Vigneron DB, Pauly J, Kurhanewicz J, Nelson SJ
• Detection of locally recurrent prostate cancer after cryosurgery: evaluation by transrectal ultrasound, magnetic resonance imaging, and three-dimensional proton magnetic resonance spectroscopy.
  Urology 1996 Parivar F, Hricak H, Shinohara K, Kurhanewicz J, Vigneron DB, Nelson SJ, Carroll PR
• Prostate cancer: metabolic response to cryosurgery as detected with 3D H-1 MR spectroscopic imaging.
  Radiology 1996 Kurhanewicz J, Vigneron DB, Hricak H, Parivar F, Nelson SJ, Shinohara K, Carroll PR
• Hormonal ablation of prostatic cancer: effects on prostate morphology, tumor detection, and staging by endorectal coil MR imaging.
  AJR. American journal of roentgenology 1996 Chen M, Hricak H, Kalbhen CL, Kurhanewicz J, Vigneron DB, Weiss JM, Carroll PR
• Prostate carcinoma: MR imaging findings after cryosurgery.
  Radiology 1996 Kalbhen CL, Hricak H, Shinohara K, Chen M, Parivar F, Kurhanewicz J, Vigneron DB, Carroll PR
• Three-dimensional H-1 MR spectroscopic imaging of the in situ human prostate with high (0.24-0.7-cm3) spatial resolution.
  Radiology 1996 Kurhanewicz J, Vigneron DB, Hricak H, Narayan P, Carroll P, Nelson SJ
• Prostate cancer: effect of postbiopsy hemorrhage on interpretation of MR images.
  Radiology 1995 White S, Hricak H, Forstner R, Kurhanewicz J, Vigneron DB, Zaloudek CJ, Weiss JM, Narayan P, Carroll PR
• Citrate as an in vivo marker to discriminate prostate cancer from benign prostatic hyperplasia and normal prostate peripheral zone: detection via localized proton spectroscopy.
  Urology 1995 Kurhanewicz J, Vigneron DB, Nelson SJ, Hricak H, MacDonald JM, Konety B, Narayan P
• Carcinoma of the prostate gland: MR imaging with pelvic phased-array coils versus integrated endorectal--pelvic phased-array coils.
  Radiology 1994 Hricak H, White S, Vigneron D, Kurhanewicz J, Kosco A, Levin D, Weiss J, Narayan P, Carroll PR
• 31P magnetic resonance spectroscopy after combined hyperthermia and radiation.
  Current eye research 1994 Kurhanewicz J, Char DH, Stauffer P, Quivey JM, James TL
• 13-cis-retinoic acid-mediated growth inhibition of DU-145 human prostate cancer cells.
  Biochemistry and molecular biology international 1994 Dahiya R, Boyle B, Park HD, Kurhanewicz J, Macdonald JM, Narayan P
• Citrate alterations in primary and metastatic human prostatic adenocarcinomas: 1H magnetic resonance spectroscopy and biochemical study.
  Magnetic resonance in medicine 1993 Kurhanewicz J, Dahiya R, Macdonald JM, Chang LH, James TL, Narayan P
• Effect of glucose and confluency on phosphorus metabolites of perfused human prostatic adenocarcinoma cells as determined by 31P MRS.
  Magnetic resonance in medicine 1993 Macdonald JM, Kurhanewicz J, Dahiya R, Espanol MT, Chang LH, Goldberg B, James TL, Narayan P
• Phosphorus metabolite characterization of human prostatic adenocarcinoma in a nude mouse model by 31P magnetic resonance spectroscopy and high pressure liquid chromatography.
  NMR in biomedicine 1992 Kurhanewicz J, Dahiya R, Macdonald JM, Jajodia P, Chang LH, James TL, Narayan P
• Magnetic resonance spectroscopy in prostate disease: diagnostic possibilities and future developments.
  The Prostate. Supplement 1992 Narayan P, Kurhanewicz J
• 31P spectroscopy of the human prostate gland in vivo using a transrectal probe.
  Magnetic resonance in medicine 1991 Kurhanewicz J, Thomas A, Jajodia P, Weiner MW, James TL, Vigneron DB, Narayan P
• 31P magnetic resonance spectroscopy (MRS) of experimental orbital myositis.
  Investigative ophthalmology & visual science 1991 Winguth S, Kurhanewicz J, Wang ML, Quivey JM, James TL, Char DH
• Characterization of prostate cancer, benign prostatic hyperplasia and normal prostates using transrectal 31phosphorus magnetic resonance spectroscopy: a preliminary report.
  The Journal of urology 1991 Narayan P, Jajodia P, Kurhanewicz J, Thomas A, MacDonald J, Hubesch B, Hedgcock M, Anderson CM, James TL, Tanagho EA
• 31P magnetic resonance spectroscopy of animal uveal melanoma.
  Investigative ophthalmology & visual science 1990 Kurhanewicz J, Winguth SD, Char DH, Kaleta S, Kindy-Degnan N, Swift PS, Stauffer PR, Wendland MF, Lovato A, Chang LH
• Diffusion-weighted MR imaging of acute stroke: correlation with T2-weighted and magnetic susceptibility-enhanced MR imaging in cats.
  AJNR. American journal of neuroradiology 1990 Moseley ME, Kucharczyk J, Mintorovitch J, Cohen Y, Kurhanewicz J, Derugin N, Asgari H, Norman D
• MRS of ischemic/hypoxic brain disease.
  Investigative radiology 1989 Kucharczyk J, Moseley M, Kurhanewicz J, Norman D