John Kane, MD, PhD
Professor
Medicine
School of Medicine

Kane's research on lipoprotein metabolism, the management of lipoprotein disorders, and the genetic basis of heart disease and stroke is known worldwide through his publications in refereed journals and book chapters.

Kane earned his medical degree at the University of Oregon School of Medicine. He completed a residency in internal medicine at Stanford University and UCSF, followed by a fellowship in endocrinology at UCSF.

Kane was an Established Investigator and fellow of the American Heart Association. He received an outstanding achievement award from the International Atherosclerosis Society for his work in the genetics of lipoprotein metabolism and atherosclerosis. He is a diplomate of the American Board of Clinical Lipidology.

• Structural variation across 138,134 samples in the TOPMed consortium.
  bioRxiv : the preprint server for biology 2023 Jun G, English AC, Metcalf GA, Yang J, Chaisson MJ, Pankratz N, Menon VK, Salerno WJ, Krasheninina O, Smith AV, Lane JA, Blackwell T, Kang HM, Salvi S, Meng Q, Shen H, Pasham D, Bhamidipati S, …
• Elastin Degradation and Lung Function Deterioration with Remote Secondhand Tobacco Smoke Exposure in Never-smokers.
  Chronic obstructive pulmonary diseases (Miami, Fla.) 2022 Mustra Rakic J, Zeng S, Rohdin-Bibby L, Van Blarigan EL, Liu X, Ma S, Kane JP, Redberg RF, Turino GM, Oestreicher Stock E, Arjomandi M
• Whole-exome sequencing reveals damaging gene variants associated with hypoalphalipoproteinemia.
  Journal of lipid research 2022 Dong W, Wong KHY, Liu Y, Levy-Sakin M, Hung WC, Li M, Li B, Jin SC, Choi J, Lopez-Giraldez F, Vaka D, Poon A, Chu C, Lao R, Balamir M, Movsesyan I, Malloy MJ, Zhao H, Kwok PY, Kane JP, Lifton RP, …
• Dyslipidemia and diabetes mellitus: Role of lipoprotein species and interrelated pathways of lipid metabolism in diabetes mellitus.
  Current opinion in pharmacology 2021 Kane JP, Pullinger CR, Goldfine ID, Malloy MJ
• Machine learning and statistical approaches for classification of risk of coronary artery disease using plasma cytokines.
  BioData mining 2021 Saharan SS, Nagar P, Creasy KT, Stock EO, Feng J, Malloy MJ, Kane JP
• Levels of Prebeta-1 High-Density Lipoprotein Are a Strong Independent Positive Risk Factor for Coronary Heart Disease and Myocardial Infarction: A Meta-Analysis.
  Journal of the American Heart Association 2021 Pullinger CR, O'Connor PM, Naya-Vigne JM, Kunitake ST, Movsesyan I, Frost PH, Malloy MJ, Kane JP
• Ancestry-specific profiles of genetic determinants of severe hypertriglyceridemia.
  Journal of clinical lipidology 2020 Gill PK, Dron JS, Dilliott AA, McIntyre AD, Cao H, Wang J, Movsesyan IG, Malloy MJ, Pullinger CR, Kane JP, Hegele RA
• Loss-of-Function CREB3L3 Variants in Patients With Severe Hypertriglyceridemia.
  Arteriosclerosis, thrombosis, and vascular biology 2020 Dron JS, Dilliott AA, Lawson A, McIntyre AD, Davis BD, Wang J, Cao H, Movsesyan I, Malloy MJ, Pullinger CR, Kane JP, Hegele RA
• Separation of postprandial lipoproteins: improved purification of chylomicrons using an ApoB100 immunoaffinity method.
  Journal of lipid research 2019 Jones GM, Caccavello R, Palii SP, Pullinger CR, Kane JP, Mulligan K, Gugliucci A, Schwarz JM
• Three patients with homozygous familial hypercholesterolemia: Genomic sequencing and kindred analysis.
  Molecular genetics & genomic medicine 2019 Wong KHY, Levy-Sakin M, Ma W, Gonzaludo N, Mak ACY, Vaka D, Poon A, Chu C, Lao R, Balamir M, Grenville Z, Wong N, Kane JP, Kwok PY, Malloy MJ, Pullinger CR
• Cardiac 123I-MIBG normal uptake values are population-specific: Results from a cohort of controls over 60 years of age.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2019 Roberts G, Lloyd JJ, Kane JPM, Durcan R, Lawley S, Howe K, Petrides GS, O'Brien JT, Thomas AJ
• Partial LPL deletions: rare copy-number variants contributing towards severe hypertriglyceridemia.
  Journal of lipid research 2019 Dron JS, Wang J, McIntyre AD, Cao H, Robinson JF, Duell PB, Manjoo P, Feng J, Movsesyan I, Malloy MJ, Pullinger CR, Kane JP, Hegele RA
• Emerging roles of HDL in immune function.
  Current opinion in lipidology 2018 Creasy KT, Kane JP, Malloy MJ
• Severe hypertriglyceridemia is primarily polygenic.
  Journal of clinical lipidology 2018 Dron JS, Wang J, Cao H, McIntyre AD, Iacocca MA, Menard JR, Movsesyan I, Malloy MJ, Pullinger CR, Kane JP, Hegele RA
• Multi-ethnic genome-wide association study for atrial fibrillation.
  Nature genetics 2018 Roselli C, Chaffin MD, Weng LC, Aeschbacher S, Ahlberg G, Albert CM, Almgren P, Alonso A, Anderson CD, Aragam KG, Arking DE, Barnard J, Bartz TM, Benjamin EJ, Bihlmeyer NA, Bis JC, Bloom HL, …
• Levels of prebeta-1 high-density lipoprotein are elevated in 3 phenotypes of dyslipidemia.
  Journal of clinical lipidology 2017 Stock EO, Ferrara CT, O'Connor PM, Naya-Vigne JM, Frost PH, Malloy MJ, Kane JP, Pullinger CR
• Moderate statin treatment reduces prebeta-1 high-density lipoprotein levels in dyslipidemic patients.
  Journal of clinical lipidology 2017 Quinn AG, Schwemberger R, Stock EO, Movsesyan I, Axtell A, Chang S, Ishida BY, Malloy MJ, Kane JP, Pullinger CR
• Biochemical Analysis of the Lipoprotein Lipase Truncation Variant, LPLS447X, Reveals Increased Lipoprotein Uptake.
  Biochemistry 2017 Hayne CK, Lafferty MJ, Eglinger BJ, Kane JP, Neher SB
• Lipoproteins and amyloid vascular disease.
  Current opinion in lipidology 2016 Kane JP, Malloy MJ
• Familial hypercholesterolaemia: cholesterol efflux and coronary disease.
  European journal of clinical investigation 2016 Versmissen J, Vongpromek R, Yahya R, van der Net JB, van Vark-van der Zee L, Blommesteijn-Touw J, Wattimena D, Rietveld T, Pullinger CR, Christoffersen C, Dahlbäck B, Kane JP, Mulder M, Sijbrands EJ
• Infectious basophilia?
  American journal of hematology 2016 Kane JP
• Emerging molecular strategies for management of dyslipidemias.
  Current opinion in lipidology 2015 Kane JP, Malloy MJ
• Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib.
  Journal of the American College of Cardiology 2015 Nicholls SJ, Ruotolo G, Brewer HB, Kane JP, Wang MD, Krueger KA, Adelman SJ, Nissen SE, Rader DJ
• An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish.
  eLife 2015 Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger…
• Identification and metabolic profiling of patients with lysosomal acid lipase deficiency.
  Journal of clinical lipidology 2015 Pullinger CR, Stock EO, Movsesyan I, Malloy MJ, Frost PH, Tripuraneni R, Quinn AG, Ishida BY, Schaefer EJ, Asztalos BF, Kane JP
• HDL cholesterol efflux capacity and cardiovascular events.
  The New England journal of medicine 2015 Kane JP, Malloy MJ, Pullinger CR
• Exome sequencing in suspected monogenic dyslipidemias.
  Circulation. Cardiovascular genetics 2015 Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Rabès JP, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M,…
• Congenital absence of apolipoprotein E and neurological function-reply.
  JAMA neurology 2014 Malloy MJ, Kane JP
• Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function.
  JAMA neurology 2014 Mak AC, Pullinger CR, Tang LF, Wong JS, Deo RC, Schwarz JM, Gugliucci A, Movsesyan I, Ishida BY, Chu C, Poon A, Kim P, Stock EO, Schaefer EJ, Asztalos BF, Castellano JM, Wyss-Coray T, Duncan JL, …
• Aberrant hetero-disulfide bond formation by the hypertriglyceridemia-associated p.Gly185Cys APOA5 variant (rs2075291).
  Arteriosclerosis, thrombosis, and vascular biology 2014 Sharma V, Witkowski A, Witkowska HE, Dykstra A, Simonsen JB, Nelbach L, Beckstead JA, Pullinger CR, Kane JP, Malloy MJ, Watson G, Forte TM, Ryan RO
• Sebelipase alfa over 52 weeks reduces serum transaminases, liver volume and improves serum lipids in patients with lysosomal acid lipase deficiency.
  Journal of hepatology 2014 Valayannopoulos V, Malinova V, Honzík T, Balwani M, Breen C, Deegan PB, Enns GM, Jones SA, Kane JP, Stock EO, Tripuraneni R, Eckert S, Schneider E, Hamilton G, Middleton MS, Sirlin C, Kessler B, …
• Association of endothelial lipase Thr111Ile polymorphism with proliferative retinopathy in type 2 diabetes patients.
  Diabetes & metabolism 2014 Arndt C, Leclercq I, Nazeyrollas P, Durlach A, Ducasse A, Movesayan I, Socquard E, Clavel C, Malloy MM, Pullinger CR, Kane JP, Durlach V
• Lipoprotein (a), LPA Ile4399Met, and fibrin clot properties.
  Thrombosis research 2014 Rowland CM, Pullinger CR, Luke MM, Shiffman D, Green L, Movsesyan I, Devlin JJ, Malloy MJ, Kane JP, Undas A
• Impact of a 4q25 genetic variant in atrial flutter and on the risk of atrial fibrillation after cavotricuspid isthmus ablation.
  Journal of cardiovascular electrophysiology 2013 Roberts JD, Hsu JC, Aouizerat BE, Pullinger CR, Malloy MJ, Kane JP, Olgin JE, Marcus GM
• Evidence that an HMGA1 gene variant associates with type 2 diabetes, body mass index, and high-density lipoprotein cholesterol in a Hispanic-American population.
  Metabolic syndrome and related disorders 2013 Pullinger CR, Goldfine ID, Tanyolaç S, Movsesyan I, Faynboym M, Durlach V, Chiefari E, Foti DP, Frost PH, Malloy MJ, Brunetti A, Kane JP
• Needed: a better understanding of the antiatherogenic properties of HDL.
  Current opinion in lipidology 2013 Kane JP, Malloy MJ
• New horizons in lipid management.
  Journal of the American College of Cardiology 2013 Kane JP
• Deficiency of TDAG51 protects against atherosclerosis by modulating apoptosis, cholesterol efflux, and peroxiredoxin-1 expression.
  Journal of the American Heart Association 2013 Hossain GS, Lynn EG, Maclean KN, Zhou J, Dickhout JG, Lhoták S, Trigatti B, Capone J, Rho J, Tang D, McCulloch CA, Al-Bondokji I, Malloy MJ, Pullinger CR, Kane JP, Li Y, Shiffman D, Austin RC
• Clinical effect and safety profile of recombinant human lysosomal acid lipase in patients with cholesteryl ester storage disease.
  Hepatology (Baltimore, Md.) 2013 Balwani M, Breen C, Enns GM, Deegan PB, Honzík T, Jones S, Kane JP, Malinova V, Sharma R, Stock EO, Valayannopoulos V, Wraith JE, Burg J, Eckert S, Schneider E, Quinn AG
• Hyperlipidemia and cardiovascular disease.
  Current opinion in lipidology 2012 Malloy MJ, Kane JP
• Prebeta-1 HDL and coronary heart disease.
  Current opinion in lipidology 2012 Kane JP, Malloy MJ
• New molecular insights into CETP structure and function: a review.
  Journal of lipid research 2012 Charles MA, Kane JP
• Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis.
  American journal of human genetics 2012 Jordan CT, Cao L, Roberson ED, Duan S, Helms CA, Nair RP, Duffin KC, Stuart PE, Goldgar D, Hayashi G, Olfson EH, Feng BJ, Pullinger CR, Kane JP, Wise CA, Goldbach-Mansky R, Lowes MA, Peddle L, …
• Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy.
  Heart rhythm 2012 Hong TT, Cogswell R, James CA, Kang G, Pullinger CR, Malloy MJ, Kane JP, Wojciak J, Calkins H, Scheinman MM, Tseng ZH, Ganz P, De Marco T, Judge DP, Shaw RM
• Polymorphisms and noncardioembolic stroke in three case-control studies.
  Cerebrovascular diseases (Basel, Switzerland) 2011 Luke MM, Berger K, Rowland CM, Catanese JJ, Tong CH, Ross DA, Garcia V, Kuhlenbaeumer G, Ringelstein EB, Pullinger CR, Malloy MJ, Deedwania P, Ellis SG, Kane JP, Devlin JJ, Lalouschek W, Mannhalter C
• Association between regulator of G protein signaling 9-2 and body weight.
  PloS one 2011 Waugh JL, Celver J, Sharma M, Dufresne RL, Terzi D, Risch SC, Fairbrother WG, Neve RL, Kane JP, Malloy MJ, Pullinger CR, Gu HF, Tsatsanis C, Hamilton SP, Gold SJ, Zachariou V, Kovoor A
• Relation of increased prebeta-1 high-density lipoprotein levels to risk of coronary heart disease.
  The American journal of cardiology 2011 Guey LT, Pullinger CR, Ishida BY, O'Connor PM, Zellner C, Francone OL, Laramie JM, Naya-Vigne JM, Siradze KA, Deedwania P, Redberg RF, Frost PH, Seymour AB, Kane JP, Malloy MJ
• Evaluation of polymorphisms in EWSR1 and risk of Ewing sarcoma: a report from the Childhood Cancer Survivor Study.
  Pediatric blood & cancer 2011 DuBois SG, Goldsby R, Segal M, Woo J, Copren K, Kane JP, Pullinger CR, Matthay KK, Witte J, Lessnick SL, Robison LL, Bhatia S, Strong LC
• Mechanisms of statin-induced myalgia assessed by physiogenomic associations.
  Atherosclerosis 2011 Ruaño G, Windemuth A, Wu AH, Kane JP, Malloy MJ, Pullinger CR, Kocherla M, Bogaard K, Gordon BR, Holford TR, Gupta A, Seip RL, Thompson PD
• Disruption of the murine procollagen C-proteinase enhancer 2 gene causes accumulation of pro-apoA-I and increased HDL levels.
  Journal of lipid research 2011 Francone OL, Ishida BY, de la Llera-Moya M, Royer L, Happe C, Zhu J, Chalkey RJ, Schaefer P, Cox C, Burlingame A, Kane JP, Rothblat GH
• Functional variants of the HMGA1 gene and type 2 diabetes mellitus.
  JAMA 2011 Chiefari E, Tanyolaç S, Paonessa F, Pullinger CR, Capula C, Iiritano S, Mazza T, Forlin M, Fusco A, Durlach V, Durlach A, Malloy MJ, Kane JP, Heiner SW, Filocamo M, Foti DP, Goldfine ID, Brunetti A
• Association of endothelial lipase Thr111Ile polymorphism with lipid metabolism and microvascular complications in type 2 diabetic patients.
  Diabetes & metabolism 2010 Durlach V, Durlach A, Movesayan I, Socquard E, Zellner C, Clavel C, Nazeyrollas P, Malloy MJ, Pullinger CR, Kane JP, Ducasse A, Aouizerat BE
• Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy.
  Journal of lipid research 2010 Zhang L, Song J, Cavigiolio G, Ishida BY, Zhang S, Kane JP, Weisgraber KH, Oda MN, Rye KA, Pownall HJ, Ren G
• Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
  Pharmacogenomics 2010 Ruaño G, Thompson PD, Kane JP, Pullinger CR, Windemuth A, Seip RL, Kocherla M, Holford TR, Wu AH
• Metabolic abnormalities and coronary heart disease risk in human immunodeficiency virus-infected adults.
  Metabolic syndrome and related disorders 2010 Pullinger CR, Aouizerat BE, Gay C, Coggins T, Movsesyan I, Davis H, Kane JP, Portillo C, Lee KA
• Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus.
  Atherosclerosis 2010 Shiffman D, Louie JZ, Rowland CM, Malloy MJ, Kane JP, Devlin JJ
• Effect of niacin on preβ-1 high-density lipoprotein levels in diabetes.
  Metabolism: clinical and experimental 2010 Pan J, Shilian P, Ishida B, Wu X, Kane JP, Malloy MJ, Charles MA
• High-density lipoprotein metabolism and the human embryo.
  Human reproduction update 2010 Fujimoto VY, Kane JP, Ishida BY, Bloom MS, Browne RW
• Genetic variants of the ENPP1/PC-1 gene are associated with hypertriglyceridemia in male subjects.
  Metabolic syndrome and related disorders 2009 Tanyolaç S, Bremer AA, Hodoglugil U, Movsesyan I, Pullinger CR, Heiner SW, Malloy MJ, Kane JP, Goldfine ID
• The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles.
  Atherosclerosis 2009 Arai K, Luke MM, Koschinsky ML, Miller ER, Pullinger CR, Witztum JL, Kane JP, Tsimikas S
• HDL antielastase activity prevents smooth muscle cell anoikis, a potential new antiatherogenic property.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Ortiz-Muñoz G, Houard X, Martín-Ventura JL, Ishida BY, Loyau S, Rossignol P, Moreno JA, Kane JP, Chalkley RJ, Burlingame AL, Michel JB, Meilhac O
• Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium.
  The British journal of ophthalmology 2009 Duncan KG, Hosseini K, Bailey KR, Yang H, Lowe RJ, Matthes MT, Kane JP, LaVail MM, Schwartz DM, Duncan JL
• Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1.
  Journal of lipid research 2009 Zhu J, Gardner J, Pullinger CR, Kane JP, Thompson JF, Francone OL
• Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study.
  Human molecular genetics 2008 Calton MA, Ersoy BA, Zhang S, Kane JP, Malloy MJ, Pullinger CR, Bromberg Y, Pennacchio LA, Dent R, McPherson R, Ahituv N, Vaisse C
• GOSR2 Lys67Arg is associated with hypertension in whites.
  American journal of hypertension 2008 Meyer TE, Shiffman D, Morrison AC, Rowland CM, Louie JZ, Bare LA, Ross DA, Arellano AR, Chasman DI, Ridker PM, Pankow JS, Coresh J, Malloy MJ, Kane JP, Ellis SG, Devlin JJ, Boerwinkle E
• Galanin preproprotein is associated with elevated plasma triglycerides.
  Arteriosclerosis, thrombosis, and vascular biology 2008 Plaisier CL, Kyttälä M, Weissglas-Volkov D, Sinsheimer JS, Huertas-Vazquez A, Riba L, Ramírez-Jiménez S, de Bruin TW, Tusié-Luna T, Aouizerat BE, Pullinger CR, Malloy MJ, Kane JP, Cruz-Bautista I, …
• Analysis of 17,576 potentially functional SNPs in three case-control studies of myocardial infarction.
  PloS one 2008 Shiffman D, Kane JP, Louie JZ, Arellano AR, Ross DA, Catanese JJ, Malloy MJ, Ellis SG, Devlin JJ
• Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia.
  Atherosclerosis 2008 van der Net JB, Versmissen J, Oosterveer DM, Defesche JC, Yazdanpanah M, Aouizerat BE, Steyerberg EW, Malloy MJ, Pullinger CR, Kane JP, Kastelein JJ, Sijbrands EJ
• WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.
  American journal of human genetics 2008 Lee JC, Weissglas-Volkov D, Kyttälä M, Dastani Z, Cantor RM, Sobel EM, Plaisier CL, Engert JC, van Greevenbroek MM, Kane JP, Malloy MJ, Pullinger CR, Huertas-Vazquez A, Aguilar-Salinas CA, Tusie-Luna …
• Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia.
  European heart journal 2008 van der Net JB, Oosterveer DM, Versmissen J, Defesche JC, Yazdanpanah M, Aouizerat BE, Steyerberg EW, Malloy MJ, Pullinger CR, Kastelein JJ, Kane JP, Sijbrands EJ
• An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients.
  Journal of lipid research 2008 Pullinger CR, Aouizerat BE, Movsesyan I, Durlach V, Sijbrands EJ, Nakajima K, Poon A, Dallinga-Thie GM, Hattori H, Green LL, Kwok PY, Havel RJ, Frost PH, Malloy MJ, Kane JP
• A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
  PLoS genetics 2008 Liu Y, Helms C, Liao W, Zaba LC, Duan S, Gardner J, Wise C, Miner A, Malloy MJ, Pullinger CR, Kane JP, Saccone S, Worthington J, Bruce I, Kwok PY, Menter A, Krueger J, Barton A, Saccone NL, Bowcock AM
• Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia.
  Nature genetics 2007 Péterfy M, Ben-Zeev O, Mao HZ, Weissglas-Volkov D, Aouizerat BE, Pullinger CR, Frost PH, Kane JP, Malloy MJ, Reue K, Pajukanta P, Doolittle MH
• Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.
  Arteriosclerosis, thrombosis, and vascular biology 2007 Shiffman D, O'Meara ES, Bare LA, Rowland CM, Louie JZ, Arellano AR, Lumley T, Rice K, Iakoubova O, Luke MM, Young BA, Malloy MJ, Kane JP, Ellis SG, Tracy RP, Devlin JJ, Psaty BM
• Five common gene variants identify elevated genetic risk for coronary heart disease.
  Genetics in medicine : official journal of the American College of Medical Genetics 2007 Bare LA, Morrison AC, Rowland CM, Shiffman D, Luke MM, Iakoubova OA, Kane JP, Malloy MJ, Ellis SG, Pankow JS, Willerson JT, Devlin JJ, Boerwinkle E
• Apolipoprotein E e4 allele increases the risk of early postoperative delirium in older patients undergoing noncardiac surgery.
  Anesthesiology 2007 Leung JM, Sands LP, Wang Y, Poon A, Kwok PY, Kane JP, Pullinger CR
• Assessment of lipoprotein profiles study (ALPS) and antioxidant activity in healthy subjects treated with AGI-1067.
  Journal of clinical lipidology 2007 Davidson MH, Smith J, Scott R, Small R, Choi J, Ishida BY, Kane JP, ALPS Investigators
• A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease.
  Arteriosclerosis, thrombosis, and vascular biology 2007 Luke MM, Kane JP, Liu DM, Rowland CM, Shiffman D, Cassano J, Catanese JJ, Pullinger CR, Leong DU, Arellano AR, Tong CH, Movsesyan I, Naya-Vigne J, Noordhof C, Feric NT, Malloy MJ, Topol EJ, Koschinsky…
• Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study.
  American journal of epidemiology 2007 Morrison AC, Bare LA, Chambless LE, Ellis SG, Malloy M, Kane JP, Pankow JS, Devlin JJ, Willerson JT, Boerwinkle E
• The lipoprotein lipase gene in combined hyperlipidemia: evidence of a protective allele depletion.
  Lipids in health and disease 2006 Wung SF, Kulkarni MV, Pullinger CR, Malloy MJ, Kane JP, Aouizerat BE
• Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction.
  Arteriosclerosis, thrombosis, and vascular biology 2006 Shiffman D, Rowland CM, Louie JZ, Luke MM, Bare LA, Bolonick JI, Young BA, Catanese JJ, Stiggins CF, Pullinger CR, Topol EJ, Malloy MJ, Kane JP, Ellis SG, Devlin JJ
• High density lipoprotein mediated lipid efflux from retinal pigment epithelial cells in culture.
  The British journal of ophthalmology 2006 Ishida BY, Duncan KG, Bailey KR, Kane JP, Schwartz DM
• Lack of support for the association between GAD2 polymorphisms and severe human obesity.
  PLoS biology 2005 Swarbrick MM, Waldenmaier B, Pennacchio LA, Lind DL, Cavazos MM, Geller F, Merriman R, Ustaszewska A, Malloy M, Scherag A, Hsueh WC, Rief W, Mauvais-Jarvis F, Pullinger CR, Kane JP, Dent R, McPherson …
• Identification of four gene variants associated with myocardial infarction.
  American journal of human genetics 2005 Shiffman D, Ellis SG, Rowland CM, Malloy MJ, Luke MM, Iakoubova OA, Pullinger CR, Cassano J, Aouizerat BE, Fenwick RG, Reitz RE, Catanese JJ, Leong DU, Zellner C, Sninsky JJ, Topol EJ, Devlin JJ, Kane…
• Parotid secretory protein is an HDL-associated protein with anticandidal activity.
  American journal of physiology. Regulatory, integrative and comparative physiology 2005 Khovidhunkit W, Hachem JP, Medzihradszky KF, Duchateau PN, Shigenaga JK, Moser AH, Movsesyan I, Naya-Vigne J, Kane JP, Feingold KR, Grunfeld C
• Variations in human HM74 (GPR109B) and HM74A (GPR109A) niacin receptors.
  Human mutation 2005 Zellner C, Pullinger CR, Aouizerat BE, Frost PH, Kwok PY, Malloy MJ, Kane JP
• Apolipoprotein L-I is positively associated with hyperglycemia and plasma triglycerides in CAD patients with low HDL.
  Journal of lipid research 2004 Albert TS, Duchateau PN, Deeb SS, Pullinger CR, Cho MH, Heilbron DC, Malloy MJ, Kane JP, Brown BG
• Apolipoproteins A-IV and A-V are acute-phase proteins in mouse HDL.
  Atherosclerosis 2004 Khovidhunkit W, Duchateau PN, Medzihradszky KF, Moser AH, Naya-Vigne J, Shigenaga JK, Kane JP, Grunfeld C, Feingold KR
• The primary stone event: a new hypothesis involving a vascular etiology.
  The Journal of urology 2004 Stoller ML, Meng MV, Abrahams HM, Kane JP
• Regulated expression of apolipoprotein E by human retinal pigment epithelial cells.
  Journal of lipid research 2003 Ishida BY, Bailey KR, Duncan KG, Chalkley RJ, Burlingame AL, Kane JP, Schwartz DM
• Dynamic regulation of alternative ATP-binding cassette transporter A1 transcripts.
  Biochemical and biophysical research communications 2003 Huuskonen J, Abedin M, Vishnu M, Pullinger CR, Baranzini SE, Kane JP, Fielding PE, Fielding CJ
• Apolipoprotein A-II: active or passive role in familial combined hyperlipidemia.
  Circulation research 2003 Aouizerat BE, Kane JP
• Primary hypercholesterolemia: genetic causes and treatment of five monogenic disorders.
  Expert review of cardiovascular therapy 2003 Pullinger CR, Kane JP, Malloy MJ
• Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids.
  Journal of lipid research 2003 Aouizerat BE, Kulkarni M, Heilbron D, Drown D, Raskin S, Pullinger CR, Malloy MJ, Kane JP
• The effects of physical exercise on plasma prebeta-1 high-density lipoprotein.
  Metabolism: clinical and experimental 2003 Jafari M, Leaf DA, Macrae H, Kasem J, O'conner P, Pullinger C, Malloy M, Kane JP
• Apolipoprotein L-I is the trypanosome lytic factor of human serum.
  Nature 2003 Vanhamme L, Paturiaux-Hanocq F, Poelvoorde P, Nolan DP, Lins L, Van Den Abbeele J, Pays A, Tebabi P, Van Xong H, Jacquet A, Moguilevsky N, Dieu M, Kane JP, De Baetselier P, Brasseur R, Pays E
• Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype.
  The Journal of clinical investigation 2002 Pullinger CR, Eng C, Salen G, Shefer S, Batta AK, Erickson SK, Verhagen A, Rivera CR, Mulvihill SJ, Malloy MJ, Kane JP
• Influence of an asparagine to lysine mutation at amino acid 3516 of apolipoprotein B on low-density lipoprotein receptor binding.
  Clinica chimica acta; international journal of clinical chemistry 2002 Gaffney D, Pullinger CR, O'Reilly DS, Hoffs MS, Cameron I, Vass JK, Kulkarni MV, Kane JP, Schumaker VN, Watts GF, Packard CJ
• Human retinal pigment epithelial cells express scavenger receptors BI and BII.
  Biochemical and biophysical research communications 2002 Duncan KG, Bailey KR, Kane JP, Schwartz DM
• Does hypertriglyceridemia present an indication for pioglitazone therapy in diabetes?
  Diabetes technology & therapeutics 2002 Kane JP
• Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene.
  Journal of lipid research 2001 Duchateau PN, Pullinger CR, Cho MH, Eng C, Kane JP
• A risk factor for atherosclerosis: triglyceride-rich lipoproteins.
  Advances in internal medicine 2001 Malloy MJ, Kane JP
• Elevated baseline triglyceride levels modulate effects of HMGCoA reductase inhibitors on plasma lipoproteins.
  Journal of cardiovascular pharmacology and therapeutics 2001 Drmanac S, Heilbron DC, Pullinger CR, Jafari M, Gietzen D, Ukrainczyk T, Cho MH, Frost PH, Siradze K, Drmanac RT, Kane JP, Malloy MJ
• Haplotypes of the human renin gene associated with essential hypertension and stroke.
  Journal of human hypertension 2001 Frossard PM, Malloy MJ, Lestringant GG, Kane JP
• Low levels of high density lipoproteins in Turks, a population with elevated hepatic lipase. High density lipoprotein characterization and gender-specific effects of apolipoprotein e genotype.
  Journal of lipid research 2000 Mahley RW, Pépin J, Palaoglu KE, Malloy MJ, Kane JP, Bersot TP
• Plasma apolipoprotein L concentrations correlate with plasma triglycerides and cholesterol levels in normolipidemic, hyperlipidemic, and diabetic subjects.
  Journal of lipid research 2000 Duchateau PN, Movsesyan I, Yamashita S, Sakai N, Hirano K, Schoenhaus SA, O'Connor-Kearns PM, Spencer SJ, Jaffe RB, Redberg RF, Ishida BY, Matsuzawa Y, Kane JP, Malloy MJ
• Analysis of hABC1 gene 5' end: additional peptide sequence, promoter region, and four polymorphisms.
  Biochemical and biophysical research communications 2000 Pullinger CR, Hakamata H, Duchateau PN, Eng C, Aouizerat BE, Cho MH, Fielding CJ, Kane JP
• Lack of association of lipoprotein(a) levels with coronary calcium deposits in asymptomatic postmenopausal women.
  Journal of the American College of Cardiology 2000 Nishino M, Malloy MJ, Naya-Vigne J, Russell J, Kane JP, Redberg RF
• Human renin gene BglI dimorphism associated with hypertension in two independent populations.
  Clinical genetics 1999 Frossard PM, Lestringant GG, Malloy MJ, Kane JP
• Renin gene MboI dimorphism is a discriminator for hypertension in hyperlipidaemic subjects.
  Hypertension research : official journal of the Japanese Society of Hypertension 1999 Frossard PM, Kane JP, Malloy MJ, Bener A
• A multilocus genotyping assay for candidate markers of cardiovascular disease risk.
  Genome research 1999 Cheng S, Grow MA, Pallaud C, Klitz W, Erlich HA, Visvikis S, Chen JJ, Pullinger CR, Malloy MJ, Siest G, Kane JP
• Evaluation of Langerhans' cells in the cervical epithelium of women with cervical intraepithelial neoplasia.
  Gynecologic oncology 1999 Connor JP, Ferrer K, Kane JP, Goldberg JM
• Polymorphism of the lipopolysaccharide receptor (CD14) and myocardial infarction. New evidence for a role of gram-negative bacterial infection?
  Circulation 1999 Kane JP, Havel RJ
• The apolipoprotein B R3531C mutation. Characteristics of 24 subjects from 9 kindreds.
  Journal of lipid research 1999 Pullinger CR, Gaffney D, Gutierrez MM, Malloy MJ, Schumaker VN, Packard CJ, Kane JP
• A multilocus genotyping assay for cardiovascular disease.
  Clinical chemistry and laboratory medicine 1998 Cheng S, Pallaud C, Grow MA, Scharf SJ, Erlich HA, Klitz W, Pullinger CR, Malloy MJ, Kane JP, Siest G, Visvikis S
• Prebeta-1 HDL in plasma of normolipidemic individuals: influences of plasma lipoproteins, age, and gender.
  Journal of lipid research 1998 O'Connor PM, Zysow BR, Schoenhaus SA, Ishida BY, Kunitake ST, Naya-Vigne JM, Duchateau PN, Redberg RF, Spencer SJ, Mark S, Mazur M, Heilbron DC, Jaffe RB, Malloy MJ, Kane JP
• Rationale and design of the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) study that evaluates atorvastatin in unstable angina pectoris and in non-Q-wave acute myocardial infarction.
  The American journal of cardiology 1998 Schwartz GG, Oliver MF, Ezekowitz MD, Ganz P, Waters D, Kane JP, Texter M, Pressler ML, Black D, Chaitman BR, Olsson AG
• Aggressive medical therapy for the prevention and treatment of coronary artery disease.
  Disease-a-month : DM 1998 Malloy MJ, Kane JP
• Premature coronary artery disease associated with a disruptive mutation in the estrogen receptor gene in a man.
  Circulation 1997 Sudhir K, Chou TM, Chatterjee K, Smith EP, Williams TC, Kane JP, Malloy MJ, Korach KS, Rubanyi GM
• Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L.
  The Journal of biological chemistry 1997 Duchateau PN, Pullinger CR, Orellana RE, Kunitake ST, Naya-Vigne J, O'Connor PM, Malloy MJ, Kane JP
• Measurement of prebeta-1 HDL in human plasma by an ultrafiltration-isotope dilution technique.
  Analytical biochemistry 1997 O'Connor PM, Naya-Vigne JM, Duchateau PN, Ishida BY, Mazur M, Schoenhaus SA, Zysow BR, Malloy MJ, Kunitake ST, Kane JP
• A novel apolipoprotein C-III variant, apoC-III(Gln38-->Lys), associated with moderate hypertriglyceridemia in a large kindred of Mexican origin.
  Journal of lipid research 1997 Pullinger CR, Malloy MJ, Shahidi AK, Ghassemzadeh M, Duchateau P, Villagomez J, Allaart J, Kane JP
• Isolation of subpopulations of high density lipoproteins: three particle species containing apoE and two species devoid of apoE that have affinity for heparin.
  Journal of lipid research 1997 Hennessy LK, Kunitake ST, Jarvis M, Hamilton RL, Endeman G, Protter A, Kane JP
• A single copy of apolipoprotein B-48 is present on the human chylomicron remnant.
  Journal of lipid research 1997 Phillips ML, Pullinger C, Kroes I, Kroes J, Hardman DA, Chen G, Curtiss LK, Gutierrez MM, Kane JP, Schumaker VN
• Cryo-electron microscopy of low density lipoprotein and reconstituted discoidal high density lipoprotein: imaging of the apolipoprotein moiety.
  Journal of lipid research 1997 van Antwerpen R, Chen GC, Pullinger CR, Kane JP, LaBelle M, Krauss RM, Luna-Chavez C, Forte TM, Gilkey JC
• Aggressive medical therapy for the prevention and treatment of coronary artery disease.
  Advances in internal medicine 1997 Malloy MJ, Kane JP
• The apolipoprotein B Q3405E polymorphism has no effect on its low-density-lipoprotein receptor binding affinity.
  Human genetics 1996 Pullinger CR, Love JA, Liu W, Hennessy LK, Ghassemzadeh M, Newcomb KC, Illingworth DR, Kane JP
• Angiographically silent atherosclerosis detected by intravascular ultrasound in patients with familial hypercholesterolemia and familial combined hyperlipidemia: correlation with high density lipoproteins.
  Journal of the American College of Cardiology 1996 Hausmann D, Johnson JA, Sudhir K, Mullen WL, Friedrich G, Fitzgerald PJ, Chou TM, Ports TA, Kane JP, Malloy MJ, Yock PG
• Identification of apolipoprotein B100 polymorphisms that affect low-density lipoprotein metabolism: description of a new approach involving monoclonal antibodies and dynamic light scattering.
  Biochemistry 1995 Chatterton JE, Schlapfer P, Bütler E, Gutierrez MM, Puppione DL, Pullinger CR, Kane JP, Curtiss LK, Schumaker VN
• Triglyceride-rich lipoproteins prevent septic death in rats.
  The Journal of experimental medicine 1995 Read TE, Grunfeld C, Kumwenda ZL, Calhoun MC, Kane JP, Feingold KR, Rapp JH
• Familial ligand-defective apolipoprotein B. Identification of a new mutation that decreases LDL receptor binding affinity.
  The Journal of clinical investigation 1995 Pullinger CR, Hennessy LK, Chatterton JE, Liu W, Love JA, Mendel CM, Frost PH, Malloy MJ, Schumaker VN, Kane JP
• Increased prevalence of coronary ectasia in heterozygous familial hypercholesterolemia.
  Circulation 1995 Sudhir K, Ports TA, Amidon TM, Goldberger JJ, Bhushan V, Kane JP, Yock P, Malloy MJ
• The effects of colestipol tablets compared with colestipol granules on plasma cholesterol and other lipids in moderately hypercholesterolemic patients.
  Atherosclerosis 1995 Insull W, Davidson MH, Demke DM, Dujovne CA, Eckert SM, Ginsberg D, Goldberg AC, Hodis HN, Hughes TA, Kane JP
• Triglyceride-rich lipoproteins improve survival when given after endotoxin in rats.
  Surgery 1995 Read TE, Grunfeld C, Kumwenda Z, Calhoun MC, Kane JP, Feingold KR, Rapp JH
• Triglyceride-rich lipoproteins isolated by selected-affinity anti-apolipoprotein B immunosorption from human atherosclerotic plaque.
  Arteriosclerosis and thrombosis : a journal of vascular biology 1994 Rapp JH, Lespine A, Hamilton RL, Colyvas N, Chaumeton AH, Tweedie-Hardman J, Kotite L, Kunitake ST, Havel RJ, Kane JP
• Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS.
  The Journal of experimental medicine 1994 Wurfel MM, Kunitake ST, Lichenstein H, Kane JP, Wright SD
• The apolipoprotein C-II variant apoC-IILys19-->Thr is not associated with dyslipidemia in an affected kindred.
  Clinical genetics 1994 Zysow BR, Pullinger CR, Hennessy LK, Farese RV, Ghassemzadeh M, Kane JP
• Identification of proteins associated with apolipoprotein A-I-containing lipoproteins purified by selected-affinity immunosorption.
  Biochemistry 1994 Kunitake ST, Carilli CT, Lau K, Protter AA, Naya-Vigne J, Kane JP
• Medical management of hyperlipidemic states.
  Advances in internal medicine 1994 Malloy MJ, Kane JP
• The protective effect of serum lipoproteins against bacterial lipopolysaccharide.
  European heart journal 1993 Read TE, Harris HW, Grunfeld C, Feingold KR, Kane JP, Rapp JH
• Chylomicrons enhance endotoxin excretion in bile.
  Infection and immunity 1993 Read TE, Harris HW, Grunfeld C, Feingold KR, Calhoun MC, Kane JP, Rapp JH
• Exploratory data analysis of hyperlipidemia on the Macintosh: software tools for analysis of biochemical, clinical, and genetic variables in 1677 consecutive lipid clinic patients.
  Journal of medical systems 1993 Bhushan V, Malloy MJ, Engler MM, Engler MB, Drown D, Kane JP
• Apolipoprotein A-I-containing lipoproteins, with or without apolipoprotein A-II, as progenitors of pre-beta high-density lipoprotein particles.
  Biochemistry 1993 Hennessy LK, Kunitake ST, Kane JP
• Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death.
  The Journal of clinical investigation 1993 Harris HW, Grunfeld C, Feingold KR, Read TE, Kane JP, Jones AL, Eichbaum EB, Bland GF, Rapp JH
• Molecular cloning and characteristics of a new apolipoprotein C-II mutant identified in three unrelated individuals with hypercholesterolemia and hypertriglyceridemia.
  Human molecular genetics 1993 Pullinger CR, Zysow BR, Hennessy LK, Frost PH, Malloy MJ, Kane JP
• Binding of transition metals by apolipoprotein A-I-containing plasma lipoproteins: inhibition of oxidation of low density lipoproteins.
  Proceedings of the National Academy of Sciences of the United States of America 1992 Kunitake ST, Jarvis MR, Hamilton RL, Kane JP
• A polymorphic PstI site in intron 2 of the human apolipoprotein C-II gene detected by polymerase chain reaction.
  Human genetics 1992 Zysow BR, Pullinger CR, Kane JP
• Two apolipoprotein B gene defects in a kindred with hypobetalipoproteinemia, one of which results in a truncated variant, apoB-61, in VLDL and LDL.
  Journal of lipid research 1992 Pullinger CR, Hillas E, Hardman DA, Chen GC, Naya-Vigne JM, Iwasa JA, Hamilton RL, Lalouel JM, Williams RR, Kane JP
• Relation of plasma lipid and apoprotein levels to progressive intimal hyperplasia after arterial endarterectomy.
  Circulation 1992 Colyvas N, Rapp JH, Phillips NR, Stoney R, Perez S, Kane JP, Havel RJ
• Drs malloy and kane respond.
  The Western journal of medicine 1992 Malloy MJ, Kane JP
• Chylomicrons can inhibit endotoxin activity in vitro.
  The Journal of surgical research 1991 Eichbaum EB, Harris HW, Kane JP, Rapp JH
• Molecular and metabolic basis for the metabolic disorder normotriglyceridemic abetalipoproteinemia.
  The Journal of clinical investigation 1991 Hardman DA, Pullinger CR, Hamilton RL, Kane JP, Malloy MJ
• Niacin--the long and the short of it.
  The Western journal of medicine 1991 Malloy MJ, Frost PH, Kane JP
• Detection of endotoxin in triglyceride-rich lipoproteins in vitro.
  The Journal of laboratory and clinical medicine 1991 Harris HW, Eichbaum EB, Kane JP, Rapp JH
• Differences in local conformation in human apolipoprotein B-100 of plasma low density and very low density lipoproteins as identified by cathepsin D.
  The Journal of biological chemistry 1991 Chen GC, Lau K, Hamilton RL, Kane JP
• Familial chylomicronemia (type I hyperlipoproteinemia) due to a single missense mutation in the lipoprotein lipase gene.
  The Journal of clinical investigation 1991 Ameis D, Kobayashi J, Davis RC, Ben-Zeev O, Malloy MJ, Kane JP, Lee G, Wong H, Havel RJ, Schotz MC
• Two apolipoprotein E5 variants illustrate the importance of the position of additional positive charge on receptor-binding activity.
  Journal of lipid research 1991 Wardell MR, Rall SC, Schaefer EJ, Kane JP, Weisgraber KH
• Regression of coronary atherosclerosis during treatment of familial hypercholesterolemia with combined drug regimens.
  JAMA 1990 Kane JP, Malloy MJ, Ports TA, Phillips NR, Diehl JC, Havel RJ
• Conformation of apolipoprotein B-100 in the low density lipoproteins of tangier disease. Identification of localized conformational response to triglyceride content.
  The Journal of biological chemistry 1990 Kunitake ST, Young SG, Chen GC, Pullinger CR, Zhu S, Pease RJ, Scott J, Hass P, Schilling J, Kane JP
• Pre-beta high density lipoprotein. Unique disposition of apolipoprotein A-I increases susceptibility to proteolysis.
  Arteriosclerosis (Dallas, Tex.) 1990 Kunitake ST, Chen GC, Kung SF, Schilling JW, Hardman DA, Kane JP
• Treatment of hyperlipidemia.
  Annual review of medicine 1990 Kane JP, Malloy MJ
• Structural domains of human apolipoprotein B-100. Differential accessibility to limited proteolysis of B-100 in low density and very low density lipoproteins.
  The Journal of biological chemistry 1989 Chen GC, Zhu S, Hardman DA, Schilling JW, Lau K, Kane JP
• Distribution of lipid-binding regions in human apolipoprotein B-100.
  Biochemistry 1989 Chen GC, Hardman DA, Hamilton RL, Mendel CM, Schilling JW, Zhu S, Lau K, Wong JS, Kane JP
• Particle size distribution of lipoproteins from human atherosclerotic plaque: a preliminary report.
  Journal of vascular surgery 1989 Rapp JH, Harris HW, Hamilton RL, Krupski WC, Reilly LM, Ehrenfeld WK, Stoney RJ, Goldstone J, Kane JP
• Neutralization of mouse xenotropic virus by lipoproteins involves binding to the virions.
  The Journal of general virology 1988 Sernatinger J, Hoffman A, Hardman D, Kane JP, Levy JA
• Radiation inactivation of binding sites for high-density lipoproteins in human liver membranes.
  Biochimica et biophysica acta 1988 Mendel CM, Kunitake ST, Hong K, Erickson SK, Kane JP, Kempner ES
• Bsm I RFLP at the human apolipoprotein AI-CIII gene complex locus.
  Nucleic acids research 1988 Coleman RT, Cawthon RM, Malloy MJ, Kane JP, Nakashima PF, Frossard PM
• NcoI dimorphic site located 8kb 3' to the human apolipoprotein AIV (APOA4) gene.
  Nucleic acids research 1988 Coleman RT, Malloy MJ, Kane JP, Frossard PM
• Determinants of kallikrein proteolysis of apolipoprotein B-100 in human blood plasma.
  European journal of clinical investigation 1988 Gustafson A, Kane JP, Havel RJ
• Radiation inactivation of binding sites for high density lipoproteins in human fibroblast membranes.
  The Journal of biological chemistry 1988 Mendel CM, Kunitake ST, Kane JP, Kempner ES
• When to treat hyperlipidemia.
  Advances in internal medicine 1988 Kane JP, Malloy MJ
• Carboxyl terminal analysis of human B-48 protein confirms the novel mechanism proposed for chain termination.
  Biochemical and biophysical research communications 1987 Hardman DA, Protter AA, Schilling JW, Kane JP
• Complementarity of colestipol, niacin, and lovastatin in treatment of severe familial hypercholesterolemia.
  Annals of internal medicine 1987 Malloy MJ, Kane JP, Kunitake ST, Tun P
• Human apolipoprotein CI (apoC1) gene locus: DraI dimorphic site.
  Nucleic acids research 1987 Frossard PM, Coleman RT, Malloy MJ, Kane JP, Levy-Wilson B, Appleby VA
• Human apolipoprotein CI (ApoC1) gene locus: BglI dimorphic site.
  Nucleic acids research 1987 Frossard PM, Lim DW, Coleman RT, Funke H, Assmann G, Malloy MJ, Kane JP
• DraI RFLP in the human apolipoprotein AI-CIII-AIV gene complex.
  Nucleic acids research 1986 Frossard PM, Coleman RT, Dillan NA, Lim DW, Malloy MJ, Kane JP, Funke H, Assmann G
• TaqI and XbaI RFLPs detected with a human apo IV (Apo4) cDNA probe.
  Nucleic acids research 1986 Coleman RT, Dillan NA, Lim DW, Malloy MJ, Kane JP, Frossard PM
• Metabolism of apolipoproteins B-48 and B-100 of triglyceride-rich lipoproteins in patients with familial dysbetalipoproteinemia.
  The Journal of clinical investigation 1986 Stalenhoef AF, Malloy MJ, Kane JP, Havel RJ
• Analysis of cDNA clones encoding the entire B-26 region of human apolipoprotein B.
  Proceedings of the National Academy of Sciences of the United States of America 1986 Protter AA, Hardman DA, Sato KY, Schilling JW, Yamanaka M, Hort YJ, Hjerrild KA, Chen GC, Kane JP
• Scission of human apolipoprotein B-100 by kallikrein: characterization of the cleavage site.
  Biochemical and biophysical research communications 1986 Hardman DA, Gustafson A, Schilling JW, Donaldson VH, Kane JP
• Isolation of a cDNA clone encoding the amino-terminal region of human apolipoprotein B.
  Proceedings of the National Academy of Sciences of the United States of America 1986 Protter AA, Hardman DA, Schilling JW, Miller J, Appleby V, Chen GC, Kirsher SW, McEnroe G, Kane JP
• A variant primary structure of apolipoprotein C-II in individuals of African descent.
  The Journal of clinical investigation 1986 Menzel HJ, Kane JP, Malloy MJ, Havel RJ
• Discrimination between subclasses of human high-density lipoproteins by the HDL binding sites of bovine liver.
  Biochimica et biophysica acta 1986 Mendel CM, Kunitake ST, Kane JP
• Speciation of HDL.
  Advances in experimental medicine and biology 1986 Kane JP
• Treatment of hypercholesterolemia.
  Annual review of medicine 1986 Kane JP, Havel RJ
• Apolipoprotein A-I-containing lipoproteins with pre-beta electrophoretic mobility.
  Journal of lipid research 1985 Kunitake ST, La Sala KJ, Kane JP
• Circular dichroic spectra of apolipoprotein E in model complexes and cholesterol-rich lipoproteins: lipid contribution.
  Biochemistry 1984 Chen GC, Guo LS, Hamilton RL, Gordon V, Richards EG, Kane JP
• Thermal behavior of cores of human serum triglyceride-rich lipoproteins: a study of induced circular dichroism of beta-carotene.
  Biochemistry 1984 Chen GC, Kane JP, Hamilton RL
• Characteristics of human lipoproteins isolated by selected-affinity immunosorption of apolipoprotein A-I.
  Proceedings of the National Academy of Sciences of the United States of America 1984 McVicar JP, Kunitake ST, Hamilton RL, Kane JP
• Metabolism of apolipoproteins B-48 and B-100 of triglyceride-rich lipoproteins in normal and lipoprotein lipase-deficient humans.
  Proceedings of the National Academy of Sciences of the United States of America 1984 Stalenhoef AF, Malloy MJ, Kane JP, Havel RJ
• Sex-related differences in the concentrations of apolipoprotein E in human blood plasma and plasma lipoproteins.
  Journal of lipid research 1983 Phillips NR, Havel RJ, Kane JP
• Secretion of lipoproteins from the liver of normal and Watanabe heritable hyperlipidemic rabbits.
  Proceedings of the National Academy of Sciences of the United States of America 1983 Hornick CA, Kita T, Hamilton RL, Kane JP, Havel RJ
• Apolipoprotein and size heterogeneity in human umbilical cord blood low density lipoproteins.
  Biochimica et biophysica acta 1983 Davis PA, Forte TM, Kane JP, Hardman DA, Krauss RM, Blum CB
• Atypical familial dysbetalipoproteinemia associated with apolipoprotein phenotype E3/3.
  The Journal of clinical investigation 1983 Havel RJ, Kotite L, Kane JP, Tun P, Bersot T
• Cholesterol net transport, esterification, and transfer in human hyperlipidemic plasma.
  The Journal of clinical investigation 1983 Fielding PE, Fielding CJ, Havel RJ, Kane JP, Tun P
• Apolipoprotein B: structural and metabolic heterogeneity.
  Annual review of physiology 1983 Kane JP
• Remnants of lipoproteins of intestinal and hepatic origin in familial dysbetalipoproteinemia.
  Arteriosclerosis (Dallas, Tex.) 1983 Kane JP, Chen GC, Hamilton RL, Hardman DA, Malloy MJ, Havel RJ
• Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia.
  Arteriosclerosis (Dallas, Tex.) 1982 Havel RJ, Kita T, Kotite L, Kane JP, Hamilton RL, Goldstein JL, Brown MS
• Factors affecting the integrity of high density lipoproteins in the ultracentrifuge.
  Journal of lipid research 1982 Kunitake ST, Kane JP
• Serum apolipoprotein A-I levels: relationship to lipoprotein lipid levels and selected demographic variables.
  American journal of epidemiology 1982 Phillips NR, Havel RJ, Kane JP
• Characterization and quantitation of apolipoproteins A-I and E of normal and cholesterol-fed guinea pigs.
  Journal of lipid research 1982 Guo LS, Hamilton RL, Kane JP, Fielding CJ, Chen GC
• Transfer of mouse anti-xenotropic virus neutralizing factor to human lipoproteins.
  Journal of virology 1982 Levy JA, Dimpfl J, Hardman D, Kane JP
• Hypolipidemia.
  The Medical clinics of North America 1982 Malloy MJ, Kane JP
• Treatment of hypercholesterolemia.
  The Medical clinics of North America 1982 Kane JP, Malloy MJ
• Apolipoprotein B (B-48) of rat chylomicrons is not a precursor of the apolipoprotein of low density lipoproteins.
  Proceedings of the National Academy of Sciences of the United States of America 1982 Van't Hooft FM, Hardman DA, Kane JP, Havel RJ
• Therapy of hyperlipidemic states.
  Annual review of medicine 1982 Havel RJ, Kane JP
• Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows.
  The Journal of clinical investigation 1981 Schneider WJ, Kovanen PT, Brown MS, Goldstein JL, Utermann G, Weber W, Havel RJ, Kotite L, Kane JP, Innerarity TL, Mahley RW
• Normotriglyceridemic abetalipoproteinemia. absence of the B-100 apolipoprotein.
  The Journal of clinical investigation 1981 Malloy MJ, Kane JP, Hardman DA, Hamilton RL, Dalal KB
• Normalization of low-density-lipoprotein levels in heterozygous familial hypercholesterolemia with a combined drug regimen.
  The New England journal of medicine 1981 Kane JP, Malloy MJ, Tun P, Phillips NR, Freedman DD, Williams ML, Rowe JS, Havel RJ
• Levels and interrelationships of serum and lipoprotein cholesterol and triglycerides. Association with adiposity and the consumption of ethanol, tobacco, and beverages containing caffeine.
  Arteriosclerosis (Dallas, Tex.) 1981 Phillips NR, Havel RJ, Kane JP
• Human apolipoprotein C-I: concentration in blood serum and lipoproteins.
  Biochemical medicine 1980 Polz E, Kotite L, Havel RJ, Kane JP, Sata T
• Radioimmunoassay of human arginine-rich apolipoprotein, apoprotein E. Concentration in blood plasma and lipoproteins as affected by apoprotein E-3 deficiency.
  The Journal of clinical investigation 1980 Havel RJ, Kotite L, Vigne JL, Kane JP, Tun P, Phillips N, Chen GC
• beta-Carotene as a probe of lipid domains of reconstituted human plasma low-density lipoprotein: induced circular dichroism.
  Biochemistry 1980 Chen GC, Krieger M, Kane JP, Wu CS, Brown MS, Goldstein JL
• Pancreatic alpha and beta cell function in familial dysbetalipoproteinemia.
  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 1980 Tan MH, Havel RJ, Gerich JE, Soeldner JS, Kane JP
• Heterogeneity of apolipoprotein B: isolation of a new species from human chylomicrons.
  Proceedings of the National Academy of Sciences of the United States of America 1980 Kane JP, Hardman DA, Paulus HE
• Apolipoprotein is responsible for neutralization of xenotropic type C virus by mouse serum.
  Proceedings of the National Academy of Sciences of the United States of America 1979 Kane JP, Hardman DA, Dimpfl JC, Levy JA
• Secondary structure in very low density and intermediate density lipoproteins of human serum.
  Journal of lipid research 1979 Chen GC, Kane JP
• Isoelectric heterogeneity of the cofactor protein for lipoprotein lipase in human blood plasma.
  Biochemical medicine 1979 Havel RJ, Kotite L, Kane JP
• Normocholesterolemic dysbetalipoproteinemia with xanthomatosis.
  Metabolism: clinical and experimental 1979 Abrams JJ, Grundy SM, Kane JP, Chang CM
• Heterogeneity of hemoglobin gamma chains in normal newborns and in cases of alpha and beta thalassemia.
  American journal of hematology 1979 Lie-Injo LE, Randhawa ZI, Kane JP, Ganesan J, George R
• Molecular weight distributions of polydisperse systems: application to very low density lipoproteins.
  Biochemistry 1978 Kunitake ST, Loh E, Schumaker VN, Ma SK, Knobler CM, Kane JP, Hamilton RL
• Familial hypercholesterolemia in children: treatment with p-aminosalicylic acid.
  Pediatrics 1978 Malloy MJ, Kane JP, Rowe JS
• Bladder cancer and squamous metaplasia in spinal cord injury patients.
  The Journal of urology 1977 Kaufman JM, Fam B, Jacobs SC, Gabilondo F, Yalla S, Kane JP, Rossier AB
• Characterization of human very low density lipoproteins containing two electrophoretic populations: double pre-beta lipoproteinemia and primary dysbetalipoproteinemia.
  Journal of lipid research 1977 Pagnan A, Havel RJ, Kane JP, Kotite L
• Hb Leiden-beta (0) thalassemia in a Chinese with severe hemolytic anemia.
  American journal of hematology 1977 Lie-Injo LE, Ganesan J, Randhawa ZI, Peterson D, Kane JP
• New protein in human blood plasma, rich in proline, with lipid-binding properties.
  Proceedings of the National Academy of Sciences of the United States of America 1976 Sata T, Havel RJ, Kotite L, Kane JP
• Effects of a 3-day fast and of ethanol on splanchnic metabolism of FFA, amino acids, and carbohydrates in healthy young men.
  The Journal of clinical investigation 1976 Wolfe BM, Havel JR, Marliss EB, Kane JP, Seymour J, Ahuja SP
• Apoprotein composition of very low density lipoproteins of human serum.
  The Journal of clinical investigation 1975 Kane JP, Sata T, Hamilton RL, Havel RJ
• Metabolism of apoprotein B of plasma very low density lipoproteins in the rat.
  The Journal of clinical investigation 1975 Faergeman O, Sata T, Kane JP, Havel RJ
• Quantification of triglyceride transport in blood plasma: a critical analysis.
  Federation proceedings 1975 Havel RJ, Kane JP
• Stability of the apoprotein of human serum low density lipoprotein: absence of endogenous endopeptidase activity.
  Biochemical and biophysical research communications 1975 Chapman MJ, Kane JP
• The complement system in cryoglobulinaemia. Interaction with immunoglobulins and lipoproteins.
  Clinical and experimental immunology 1975 Linscott WD, Kane JP
• Temperature dependence of the optical activity of human serum low density lipoprotein. The role of lipids.
  Biochemistry 1975 Chen GC, Kane JP
• Editorial: Early prevention of atherosclerosis.
  The Western journal of medicine 1975 Kane JP, Malloy MJ
• Contribution of carotenoids to the optical activity of human serum low-density lipoprotein.
  Biochemistry 1974 Chen GC, Kane JP
• Mechanism of the hypolipemic effect of clofibrate in postabsorptive man.
  The Journal of clinical investigation 1973 Wolfe BM, Kane JP, Havel RJ, Brewster HP
• Primary dysbetalipoproteinemia: predominance of a specific apoprotein species in triglyceride-rich lipoproteins.
  Proceedings of the National Academy of Sciences of the United States of America 1973 Havel RJ, Kane JP
• A rapid electrophoretic technique for identification of subunit species of apoproteins in serum lipoproteins.
  Analytical biochemistry 1973 Kane JP
• Drugs and lipid metabolism.
  Annual review of pharmacology 1973 Havel RJ, Kane JP
• Interchange of apolipoproteins between chylomicrons and high density lipoproteins during alimentary lipemia in man.
  The Journal of clinical investigation 1973 Havel RJ, Kane JP, Kashyap ML
• Cholestasis: lamellar structure of the abnormal human serum lipoprotein.
  Science (New York, N.Y.) 1971 Hamilton RL, Havel RJ, Kane JP, Blaurock AE, Sata T
• Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans.
  The Journal of clinical investigation 1970 Havel RJ, Kane JP, Balasse EO, Segel N, Basso LV
• Subunit heterogeneity in human serum beta lipoprotein.
  Proceedings of the National Academy of Sciences of the United States of America 1970 Kane JP, Richards EG, Havel RJ
• Splanchnic metabolism in von Gierke's disease (glycogenosis type I).
  Transactions of the Association of American Physicians 1969 Havel RJ, Balasse EO, Williams HE, Kane JP, Segel N
• STUDIES OF CARBOHYDRATE METABOLISM IN IDIOPATHIC HYPERTRIGLYCERIDEMIA.
  Metabolism: clinical and experimental 1965 KANE JP, LONGCOPE C, PAVLATOS FC, GRODSKY GM
• Sterol biosynthesis under the influence of a thyroxine analog (3,5-diiodothyroacetic acid).
  Metabolism: clinical and experimental 1962 KANE JP, FORSHAM PH