John Imboden, JR, MD
Professor Emeritus
Medicine
School of Medicine

Websites

Show all (1) Hide

• Profile at rheumatology.medicine.ucsf.edu (rheumatology.medicine.ucsf.edu)

Grants and Projects

Show all (5) Hide

• Immunodominant Epitopes in Kawasaki Disease, NIH, 2007-2010
• Costimulation of T Lymphocytes of Cd28, NIH, 1988-2005
• Mutational Analysis of Ctla-4 Function in Vivo, NIH, 1999-2003
• Mycobacterium Tuberculosis;induced Macrophage Signalling, NIH, 1993-2003
• Gp35--a Signal Transducer on Nk Cell, NIH, 1990-1995

Publications (99)

Top publication keywords:
Drug ContaminationNervous System DiseasesLymphocyte ActivationT-LymphocytesPolyarteritis NodosaInterleukin-2Rheumatic DiseasesAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisAntigens, Differentiation, T-LymphocyteReceptors, Antigen, T-CellArthritis, RheumatoidLevamisoleCD28 AntigensPeripheral Nervous System DiseasesCocaine

• Structural Changes over a Short Period Are Associated with Functional Assessments in Rheumatoid Arthritis.
  The Journal of rheumatology 2019 Shimizu T, Cruz A, Tanaka M, Mamoto K, Pedoia V, Burghardt AJ, Heilmeier U, Link TM, Graf J, Imboden JB, Li X
• Vasculitis and peripheral neuropathy.
  Current opinion in rheumatology 2019 Graf J, Imboden J
• Smoking Is Associated with Higher Disease Activity in Rheumatoid Arthritis: A Longitudinal Study Controlling for Time-varying Covariates.
  The Journal of rheumatology 2018 Gianfrancesco MA, Trupin L, Shiboski S, van der Laan M, Graf J, Imboden J, Yazdany J, Schmajuk G
• Association of High Anti-Cyclic Citrullinated Peptide Seropositivity and Lean Mass Index With Low Bone Mineral Density in Rheumatoid Arthritis.
  Arthritis care & research 2018 Wysham KD, Shoback DM, Imboden JB, Katz PP
• Hypomethylation of CYP2E1 and DUSP22 Promoters Associated With Disease Activity and Erosive Disease Among Rheumatoid Arthritis Patients.
  Arthritis & rheumatology (Hoboken, N.J.) 2018 Mok A, Rhead B, Holingue C, Shao X, Quach HL, Quach D, Sinclair E, Graf J, Imboden J, Link T, Harrison R, Chernitskiy V, Barcellos LF, Criswell LA

Show all (94 more) Hide

• Neurologic Manifestations of Rheumatic Diseases.
  Rheumatic diseases clinics of North America 2017 Goglin SE, Imboden JB
• Neurologic Manifestations of Rheumatic Diseases.
  Rheumatic Disease Clinics of North America 2017 Sarah E. Goglin, John B. Imboden
• Assessment of 3-month changes in bone microstructure under anti-TNFα therapy in patients with rheumatoid arthritis using high-resolution peripheral quantitative computed tomography (HR-pQCT).
  Arthritis research & therapy 2017 Shimizu T, Choi HJ, Heilmeier U, Tanaka M, Burghardt AJ, Gong J, Chanchek N, Link TM, Graf J, Imboden JB, Li X
• Neurologic Manifestations of Rheumatoid Arthritis.
  Rheumatic diseases clinics of North America 2017 DeQuattro K, Imboden JB
• Involvement of the Peripheral Nervous System in Polyarteritis Nodosa and Antineutrophil Cytoplasmic Antibodies-Associated Vasculitis.
  Rheumatic diseases clinics of North America 2017 Imboden JB
• Current Assays to Determine Free 25-Hydroxyvitamin D in Serum.
  Journal of AOAC International 2017 Malmstroem S, Rejnmark L, Imboden JB, Shoback DM, Bikle DD
• Evaluating radiocarpal cartilage matrix changes 3-months after anti-TNF treatment for rheumatoid arthritis using MR T1ρ imaging.
  Journal of magnetic resonance imaging : JMRI 2016 Ku E, Pedoia V, Tanaka M, Heilmeier U, Imboden J, Graf J, Link T, Li X
• Use of Low-Literacy Decision Aid to Enhance Knowledge and Reduce Decisional Conflict Among a Diverse Population of Adults With Rheumatoid Arthritis: Results of a Pilot Study.
  Arthritis care & research 2016 Barton JL, Trupin L, Schillinger D, Evans-Young G, Imboden J, Montori VM, Yelin E
• SAT0545 The Effect of anti-TNF Alpha Treatment on Erosion Progression in Rheumatoid Arthritis by High-Resolution Peripheral Quantitative Computed Tomography: Three-Month Data.
  Annals of the Rheumatic Diseases 2016 H. Choi, U. Heilmeier, M. Tanaka, A.J. Burghardt, N. Chanchek, T.M. Link, J. Graft, J.B. Imboden, X. Li
• High-temporospatial-resolution dynamic contrast-enhanced (DCE) wrist MRI with variable-density pseudo-random circular Cartesian undersampling (CIRCUS) acquisition: evaluation of perfusion in rheumatoid arthritis patients.
  NMR in biomedicine 2015 Liu J, Pedoia V, Heilmeier U, Ku E, Su F, Khanna S, Imboden J, Graf J, Link T, Li X
• Efficiency Gains for Rheumatology Consultation Using a Novel Electronic Referral System in a Safety-Net Health Setting.
  Arthritis care & research 2015 Scheibe MM, Imboden JB, Schmajuk G, Margaretten M, Graf JD, Chen AH, Yelin EH, Yazdany J
• Update in rheumatology: evidence published in 2014.
  Annals of internal medicine 2015 Hellmann DB, Imboden JB
• Quantitative characterization of metacarpal and radial bone in rheumatoid arthritis using high resolution- peripheral quantitative computed tomography.
  International journal of rheumatic diseases 2015 Yang H, Yu A, Burghardt AJ, Virayavanich W, Link TM, Imboden JB, Li X
• Computer-aided and manual quantifications of MRI synovitis, bone marrow edema-like lesions, erosion and cartilage loss in rheumatoid arthritis of the wrist.
  Skeletal radiology 2014 Yang H, Rivoire J, Hoppe M, Srikhum W, Imboden J, Link TM, Li X
• Depletion of B-cells with rituximab improves endothelial function and reduces inflammation among individuals with rheumatoid arthritis.
  Journal of the American Heart Association 2014 Hsue PY, Scherzer R, Grunfeld C, Imboden J, Wu Y, Del Puerto G, Nitta E, Shigenaga J, Schnell Heringer A, Ganz P, Graf J
• Correlation of structural abnormalities of the wrist and metacarpophalangeal joints evaluated by high-resolution peripheral quantitative computed tomography, 3 Tesla magnetic resonance imaging and conventional radiographs in rheumatoid arthritis.
  International journal of rheumatic diseases 2014 Lee CH, Srikhum W, Burghardt AJ, Virayavanich W, Imboden JB, Link TM, Li X
• Pauci-immune glomerulonephritis in individuals with disease associated with levamisole-adulterated cocaine: a series of 4 cases.
  Medicine 2014 Carlson AQ, Tuot DS, Jen KY, Butcher B, Graf J, Sam R, Imboden JB
• Bone structure and perfusion quantification of bone marrow edema pattern in the wrist of patients with rheumatoid arthritis: a multimodality study.
  The Journal of rheumatology 2014 Teruel JR, Burghardt AJ, Rivoire J, Srikhum W, Noworolski SM, Link TM, Imboden JB, Li X
• English language proficiency, health literacy, and trust in physician are associated with shared decision making in rheumatoid arthritis.
  The Journal of rheumatology 2014 Barton JL, Trupin L, Tonner C, Imboden J, Katz P, Schillinger D, Yelin E
• Methotrexate and a spleen tyrosine kinase inhibitor cooperate to inhibit responses to peripheral blood B cells in rheumatoid arthritis.
  Pharmacology research & perspectives 2013 Coffey G, Betz A, Graf J, Stephens G, Hua Lin P, Imboden J, Sinha U
• Quantitative in vivo HR-pQCT imaging of 3D wrist and metacarpophalangeal joint space width in rheumatoid arthritis.
  Annals of biomedical engineering 2013 Burghardt AJ, Lee CH, Kuo D, Majumdar S, Imboden JB, Link TM, Li X
• Extraarticular manifestations of rheumatoid arthritis in a multiethnic cohort of predominantly Hispanic and Asian patients.
  Medicine 2013 Richman NC, Yazdany J, Graf J, Chernitskiy V, Imboden JB
• Quantitative and semiquantitative bone erosion assessment on high-resolution peripheral quantitative computed tomography in rheumatoid arthritis.
  The Journal of rheumatology 2013 Srikhum W, Virayavanich W, Burghardt AJ, Yu A, Link TM, Imboden JB, Li X
• Poor knowledge of methotrexate associated with older age and limited English-language proficiency in a diverse rheumatoid arthritis cohort.
  Arthritis research & therapy 2013 Barton JL, Schmajuk G, Trupin L, Graf J, Imboden J, Yelin EH, Schillinger D
• A functional variant in FCRL3 is associated with higher Fc receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity.
  Arthritis and rheumatism 2012 Bajpai UD, Swainson LA, Mold JE, Graf JD, Imboden JB, McCune JM
• DEPLETION OF B-CELLS WITH RITUXIMAB IMPROVES ENDOTHELIAL FUNCTION AND REDUCES INFLAMMATION AMONG INDIVIDUALS WITH RHEUMATOID ARTHRITIS.
  Journal of the American College of Cardiology 2012 Priscilla Hsue, Carl Grunfeld, John Imboden, Yuaner Wu, Rebecca Scherzer, Saira Mohammed, Gus del Puerto, Amanda Schnell Heringer, Peter Ganz, Jonathan Graf
• Purpura, cutaneous necrosis, and antineutrophil cytoplasmic antibodies associated with levamisole-adulterated cocaine.
  Arthritis and rheumatism 2011 Graf J, Lynch K, Yeh CL, Tarter L, Richman N, Nguyen T, Kral A, Dominy S, Imboden J
• Quantitative characterization of bone marrow edema pattern in rheumatoid arthritis using 3 Tesla MRI.
  Journal of magnetic resonance imaging : JMRI 2011 Li X, Yu A, Virayavanich W, Noworolski SM, Link TM, Imboden J
• Racial and ethnic disparities in disease activity and function among persons with rheumatoid arthritis from university-affiliated clinics.
  Arthritis care & research 2011 Barton JL, Trupin L, Schillinger D, Gansky SA, Tonner C, Margaretten M, Chernitskiy V, Graf J, Imboden J, Yelin E
• Levels of plasma fibrinogen are elevated in well-controlled rheumatoid arthritis.
  Rheumatology (Oxford, England) 2011 Rooney T, Scherzer R, Shigenaga JK, Graf J, Imboden JB, Grunfeld C
• Socioeconomic determinants of disability and depression in patients with rheumatoid arthritis.
  Arthritis care & research 2011 Margaretten M, Barton J, Julian L, Katz P, Trupin L, Tonner C, Graf J, Imboden J, Yelin E
• A 23-year-old woman with fever, rash, and arthritis.
  Arthritis care & research 2010 Gratton SB, Imboden JB
• Patient-physician discordance in assessments of global disease severity in rheumatoid arthritis.
  Arthritis care & research 2010 Barton JL, Imboden J, Graf J, Glidden D, Yelin EH, Schillinger D
• Predictors of depression in a multiethnic cohort of patients with rheumatoid arthritis.
  Arthritis and rheumatism 2009 Margaretten M, Yelin E, Imboden J, Graf J, Barton J, Katz P, Julian L
• Levels of C-reactive protein associated with high and very high cardiovascular risk are prevalent in patients with rheumatoid arthritis.
  PloS one 2009 Graf J, Scherzer R, Grunfeld C, Imboden J
• Rheumatoid arthritis: model of systemic inflammation driving atherosclerosis.
  Circulation journal : official journal of the Japanese Circulation Society 2009 Ku IA, Imboden JB, Hsue PY, Ganz P
• The immunopathogenesis of rheumatoid arthritis.
  Annual review of pathology 2009 Imboden JB
• Update in rheumatology.
  Annals of internal medicine 2006 Hellmann DB, Imboden JB
• Translocation of CD28 to lipid rafts and costimulation of IL-2.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Sadra A, Cinek T, Imboden JB
• Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation.
  Nature immunology 2004 Andres PG, Howland KC, Nirula A, Kane LP, Barron L, Dresnek D, Sadra A, Imboden J, Weiss A, Abbas AK
• Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4.
  The Journal of experimental medicine 2003 Chikuma S, Imboden JB, Bluestone JA
• Analysis of inositol phospholipid turnover during lymphocyte activation.
  Current protocols in immunology 2001 Imboden JB, Shoback DM, Inokuchi S
• Multiple probing of an immunoblot membrane using a non-block technique: advantages in speed and sensitivity.
  Analytical biochemistry 2000 Sadra A, Cinek T, Imboden JB
• Cutting edge: tyrosine-independent transmission of inhibitory signals by CTLA-4.
  Journal of immunology (Baltimore, Md. : 1950) 2000 Cinek T, Sadra A, Imboden JB
• Identification of tyrosine phosphorylation sites in the CD28 cytoplasmic domain and their role in the costimulation of Jurkat T cells.
  Journal of immunology (Baltimore, Md. : 1950) 1999 Sadra A, Cinek T, Arellano JL, Shi J, Truitt KE, Imboden JB
• Mutational analysis of CD28-mediated costimulation of Jun-N-terminal kinase and IL-2 production.
  Journal of immunology (Baltimore, Md. : 1950) 1998 Barz C, Nagel T, Truitt KE, Imboden JB
• Phosphatidylinositol 3-kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK: functional and physical interaction of EMT with phosphatidylinositol 3-kinase.
  Journal of immunology (Baltimore, Md. : 1950) 1998 Lu Y, Cuevas B, Gibson S, Khan H, LaPushin R, Imboden J, Mills GB
• Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells.
  The Journal of experimental medicine 1998 Weber JR, Orstavik S, Torgersen KM, Danbolt NC, Berg SF, Ryan JC, Taskén K, Imboden JB, Vaage JT
• Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK.
  The Biochemical journal 1998 Gibson S, Truitt K, Lu Y, Lapushin R, Khan H, Imboden JB, Mills GB
• The CD28-B7 costimulatory pathway and its role in autoimmune disease.
  Journal of leukocyte biology 1997 Daikh D, Wofsy D, Imboden JB
• CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites.
  Molecular and cellular biology 1997 Shapiro VS, Truitt KE, Imboden JB, Weiss A
• Wortmannin, a phosphatidylinositol 3-kinase inhibitor, blocks antigen-mediated, but not CD3 monoclonal antibody-induced, activation of murine CD4+ T cells.
  Journal of immunology (Baltimore, Md. : 1950) 1997 Shi J, Cinek T, Truitt KE, Imboden JB
• Turning off natural killers. Innate immunity.
  Current biology : CB 1996 Imboden J
• Structural requirements for CD28-mediated costimulation of IL-2 production in Jurkat T cells.
  Journal of immunology (Baltimore, Md. : 1950) 1996 Truitt KE, Nagel T, Suen LF, Imboden JB
• The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2.
  The Journal of experimental medicine 1996 Bell GM, Fargnoli J, Bolen JB, Kish L, Imboden JB
• CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase.
  Journal of immunology (Baltimore, Md. : 1950) 1995 Truitt KE, Shi J, Gibson S, Segal LG, Mills GB, Imboden JB
• Intracellular signalling. Switching off signals.
  Current biology : CB 1995 Imboden JB, Koretsky GA
• Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor to insulin receptor substrate 1.
  Molecular endocrinology (Baltimore, Md.) 1995 Sánchez-Margalet V, Goldfine ID, Truitt K, Imboden J, Sung CK
• Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.
  The Journal of experimental medicine 1994 Truitt KE, Hicks CM, Imboden JB
• CD45-negative mutants of a rat natural killer cell line fail to lyse tumor target cells.
  Journal of immunology (Baltimore, Md. : 1950) 1993 Bell GM, Dethloff GM, Imboden JB
• Association of Src-Like Protein Tyrosine Kinases with the CD2 Cell Surface Molecule in Rat T Lymphocytes and Natural Killer Cells.
  Molecular and Cellular Biology 1992 Gregory M. Bell, Joseph B. Bolen, John B. Imboden
• Association of Src-like protein tyrosine kinases with the CD2 cell surface molecule in rat T lymphocytes and natural killer cells.
  Molecular and cellular biology 1992 Bell GM, Bolen JB, Imboden JB
• Association of Src-like protein tyrosine kinases with the CD2 cell surface molecule in rat T lymphocytes and natural killer cells.
  Molecular and Cellular Biology 1992 G M Bell, J B Bolen, J B Imboden
• Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor.
  The Journal of experimental medicine 1992 Weber JR, Bell GM, Han MY, Pawson T, Imboden JB
• The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line.
  The Journal of experimental medicine 1992 Bell GM, Seaman WE, Niemi EC, Imboden JB
• Divergent regulation of phospholipase C-alpha and phospholipase C-gamma transcripts during activation of a human T cell line.
  Journal of immunology (Baltimore, Md. : 1950) 1991 Goldfien RD, Seaman WE, Hempel WM, Imboden JB
• CD45 cross-linking regulates phospholipase C activation and tyrosine phosphorylation of specific substrates in CD3/Ti-stimulated T cells.
  Journal of immunology (Baltimore, Md. : 1950) 1991 Ledbetter JA, Schieven GL, Uckun FM, Imboden JB
• Molecular cloning of gp42, a cell-surface molecule that is selectively induced on rat natural killer cells by interleukin 2: glycolipid membrane anchoring and capacity for transmembrane signaling.
  The Journal of experimental medicine 1991 Seaman WE, Niemi EC, Stark MR, Goldfien RD, Pollock AS, Imboden JB
• Intact antigen receptor-mediated generation of inositol phosphates and increased intracellular calcium in CD4 CD8 T lymphocytes from MRL lpr mice.
  Journal of immunology (Baltimore, Md. : 1950) 1990 Budd RC, Winslow G, Inokuchi S, Imboden JB
• Antigen receptor-mediated regulation of sustained polyphosphoinositide turnover in a human T cell line. Evidence for a receptor-regulated pathway for production of phosphatidylinositol 4,5-bisphosphate.
  The Journal of biological chemistry 1990 Inokuchi S, Imboden JB
• CD28 ligation in T-cell activation: evidence for two signal transduction pathways.
  Blood 1990 JA Ledbetter, JB Imboden, GL Schieven, LS Grosmaire, PS Rabinovitch, T Lindsten, CB Thompson, CH June
• CD28 ligation in T-cell activation: evidence for two signal transduction pathways.
  Blood 1990 Ledbetter JA, Imboden JB, Schieven GL, Grosmaire LS, Rabinovitch PS, Lindsten T, Thompson CB, June CH
• Stimulation of CD5 enhances signal transduction by the T cell antigen receptor.
  The Journal of clinical investigation 1990 Imboden JB, June CH, McCutcheon MA, Ledbetter JA
• The Initiation of Human T Lymphocyte Activation (Part 1 of 2).
  1988 John B. Imboden, Arthur Weiss
• The Initiation of Human T Lymphocyte Activation (Part 2 of 2).
  1988 John B. Imboden, Arthur Weiss
• Signal transduction through CD4 receptors: stimulatory vs. inhibitory activity is regulated by CD4 proximity to the CD3/T cell receptor.
  European journal of immunology 1988 Ledbetter JA, June CH, Rabinovitch PS, Grossmann A, Tsu TT, Imboden JB
• CHAPTER 4 REGULATION OF INTERLEUKIN 2 PRODUCTION BY THE T CELL ANTIGEN RECEPTOR.
  Interleukin 1988 John B. Imboden, Arthur Weiss
• Role of the T3/T-Cell Antigen Receptor Complex in T-Cell Activation.
  The T-Cell Receptors 1988 Bernard Manger, John Imboden, Arthur Weiss
• The initiation of human T lymphocyte activation.
  Progress in allergy 1988 Imboden JB, Weiss A
• The T-cell antigen receptor regulates sustained increases in cytoplasmic free Ca2+ through extracellular Ca2+ influx and ongoing intracellular Ca2+ mobilization.
  The Biochemical journal 1987 Imboden JB, Weiss A
• The role of protein kinase C in transmembrane signaling by the T cell antigen receptor complex. Effects of stimulation with soluble or immobilized CD3 antibodies.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Manger B, Weiss A, Imboden J, Laing T, Stobo JD
• Regulation of inositol 1,4,5-trisphosphate kinase activity after stimulation of human T cell antigen receptor.
  The Journal of clinical investigation 1987 Imboden JB, Pattison G
• Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Weiss A, Shields R, Newton M, Manger B, Imboden J
• Cell surface molecules and early events involved in human T lymphocyte activation.
  Advances in immunology 1987 Weiss A, Imboden JB
• The role of the antigen receptor/T3 complex in T-cell activation.
  Advances in experimental medicine and biology 1987 Weiss A, Imboden J, Hardy K, Stobo J
• Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol trisphosphate and cytoplasmic free calcium.
  Proceedings of the National Academy of Sciences of the United States of America 1986 Imboden JB, Shoback DM, Pattison G, Stobo JD
• Synergy between the T3/antigen receptor complex and Tp44 in the activation of human T cells.
  Journal of immunology (Baltimore, Md. : 1950) 1986 Weiss A, Manger B, Imboden J
• The role of the T3/antigen receptor complex in T-cell activation.
  Annual review of immunology 1986 Weiss A, Imboden J, Hardy K, Manger B, Terhorst C, Stobo J
• Transmembrane signalling by the T3-antigen receptor complex.
  Immunology today 1985 Imboden JB, Weiss A, Stobo JD
• Activation of a human T cell line: a two-stimulus requirement in the pretranslational events involved in the coordinate expression of interleukin 2 and gamma-interferon genes.
  Journal of immunology (Baltimore, Md. : 1950) 1985 Wiskocil R, Weiss A, Imboden J, Kamin-Lewis R, Stobo J
• Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.
  The Journal of experimental medicine 1985 Imboden JB, Stobo JD
• The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium.
  Journal of immunology (Baltimore, Md. : 1950) 1985 Imboden JB, Weiss A, Stobo JD
• Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium.
  Proceedings of the National Academy of Sciences of the United States of America 1984 Weiss A, Imboden J, Shoback D, Stobo J
• The role of T3 in the activation of human T cells.
  Journal of clinical immunology 1984 Weiss A, Imboden J, Wiskocil R, Stobo J