John Houde, PhD
Professor
Otolaryngology
School of Medicine
John F. Houde, PhD, is a Professor in Residence and he is the Director of the Speech Neuroscience Laboratory in the Department of Otolaryngology – Head and Neck Surgery (OHNS) at the University of California, San Francisco.
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He received his Electrical Engineering undergraduate degree from the California Institute of Technology in Pasadena, and he obtained his MS in Computer Science from Duke University, Durham, North Carolina. Dr. Houde earned his PhD in Brain and Cognitive Science from MIT, and this was followed by a fellowship in Medicine from UCSF.
Dr. Houde’s research focuses on understanding the role of auditory feedback in speech and the neural mechanisms supporting auditory feedback. His research projects include computational modeling, psychophysical investigations, and functional neuroimaging that examine auditory feedback's role in the learning and maintenance of speech, as well as the online control of speech. A major focus of Dr. Houde’s lab is determining the role of auditory feedback in speaking by examining how speakers respond to realtime alterations of their audio feedback. Another major focus is using functional neuroimaging, especially magnetoencephalography (MEG), as well as electrocorticography (ECoG) to study how auditory feedback is processed during speaking.
Dr. Houde also studies how feedback processing in speech production is compromised in various clinical conditions, such as Alzheimer’s disease and spasmodic dysphonia.
Dr. Houde is a member of the Cognitive Neuroscience Society, the Society of Neuroscience, and the Society for the Neuroscience Language. He has contributed to 24 peer-reviewed articles, 2 patents, and over 50 abstracts.
Specialty: The neuroscience of speech production
Expertise: Research in cognitive neuroscience
Professional Interests: Speech, hearing, neuroscience, cognitive science, acoustics, auditory feedback, motor control
Education and Training:
- BS: California Institute of Technology – Electrical Engineering
- MS: Duke University – Computer Science
- PhD: Massachusetts Institute of Technology, Cambridge – Brain and Cognitive Science
- Postdoctoral Training: University of California, San Francisco
Websites
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- UCSF Speech Neuroscience Lab (speechneuro.ucsf.edu)
- Profile at sloan.ucsf.edu (sloan.ucsf.edu)
Grants and Projects
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- The role of the cerebellum in speech, NIH, 2018-2023
- Dynamic Brain Imaging of Speech in Primary Progressive Aphasia, NIH, 2017-2022
- CRCNS: Modeling the role of auditory feedback in speech motor control, NIH, 2018-2021
- Imaging sensorimotor adaptation and compensation of speech, NIH, 2014-2020
- Timing of Neural activity in Spasmodic Dysphonia, NIH, 2015-2017
- Neuroimaging of Speech Motor Control, NIH, 2010-2016
- The Neural Substrates of Impaired Feedback Control in P*, NIH, 2002-2005
Publications (73)
Top publication keywords:
Feedback, SensorySpeech AcousticsPitch PerceptionEvoked Potentials, AuditoryAuditory CortexAuditory PathwaysSpeechPhoneticsCerebellar AtaxiaFeedbackVoiceAphasia, Primary ProgressiveMagnetoencephalographyAdaptation, PhysiologicalSpeech Perception
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A randomised controlled trial investigating the causal role of the medial prefrontal cortex in mediating self-agency during speech monitoring and reality monitoring.
Scientific reports 2024 Tan S, Jia Y, Jariwala N, Zhang Z, Brent K, Houde J, Nagarajan S, Subramaniam K -
Neurophysiological evidence of sensory prediction errors driving speech sensorimotor adaptation.
bioRxiv : the preprint server for biology 2023 Kim KS, Hinkley LB, Dale CL, Nagarajan SS, Houde JF -
A randomised controlled trial investigating the causal role of the medial prefrontal cortex in mediating self-agency during speech monitoring and reality monitoring.
Research square 2023 Tan S, Jia Y, Jariwala N, Zhang Z, Brent K, Houde J, Nagarajan S, Subramaniam K -
Distinct neurophysiology during nonword repetition in logopenic and non-fluent variants of primary progressive aphasia.
Human brain mapping 2023 Hinkley LBN, Thompson M, Miller ZA, Borghesani V, Mizuiri D, Shwe W, Licata A, Ninomiya S, Lauricella M, Mandelli ML, Miller BL, Houde J, Gorno-Tempini ML, Nagarajan SS -
Mechanisms of sensorimotor adaptation in a hierarchical state feedback control model of speech.
PLoS computational biology 2023 Kim KS, Gaines JL, Parrell B, Ramanarayanan V, Nagarajan SS, Houde JF
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Impaired Speaking-Induced Suppression in Alzheimer's Disease.
eNeuro 2023 Kim KX, Dale CL, Ranasinghe KG, Kothare H, Beagle AJ, Lerner H, Mizuiri D, Gorno-Tempini ML, Vossel K, Nagarajan SS, Houde JF -
Editorial: New perspectives on the role of sensory feedback in speech production.
Frontiers in human neuroscience 2023 Houde JF, Ménard L, Jones JA, Shiller DM, Tian X -
Auditory Verb Generation Performance Patterns Dissociate Variants of Primary Progressive Aphasia.
Frontiers in psychology 2022 Lukic S, Licata AE, Weis E, Bogley R, Ratnasiri B, Welch AE, Hinkley LBN, Miller Z, Garcia AM, Houde JF, Nagarajan SS, Gorno-Tempini ML, Borghesani V -
Temporal specificity of abnormal neural oscillations during phonatory events in laryngeal dystonia.
Brain communications 2022 Kothare H, Schneider S, Mizuiri D, Hinkley L, Bhutada A, Ranasinghe K, Honma S, Garrett C, Klein D, Naunheim M, Yung K, Cheung S, Rosen C, Courey M, Nagarajan S, Houde J -
Discrete constriction locations describe a comprehensive range of vocal tract shapes in the Maeda model.
JASA express letters 2021 Gaines JL, Kim KS, Parrell B, Ramanarayanan V, Nagarajan SS, Houde JF -
Neural dynamics of semantic categorization in semantic variant of primary progressive aphasia.
eLife 2021 Borghesani V, Dale CL, Lukic S, Hinkley L, Lauricella M, Shwe W, Mizuiri D, Honma S, Miller Z, Miller B, Houde JF, Gorno-Tempini ML, Nagarajan SS -
Intact Correction for Self-Produced Vowel Formant Variability in Individuals With Cerebellar Ataxia Regardless of Auditory Feedback Availability.
Journal of speech, language, and hearing research : JSLHR 2021 Parrell B, Ivry RB, Nagarajan SS, Houde JF -
Laryngeal Dystonia: Multidisciplinary Update on Terminology, Pathophysiology, and Research Priorities.
Neurology 2021 Simonyan K, Barkmeier-Kraemer J, Blitzer A, Hallett M, Houde JF, Jacobson Kimberley T, Ozelius LJ, Pitman MJ, Richardson RM, Sharma N, Tanner K, The NIH/NIDCD Workshop on Research Priorities in … -
Speech compensation responses and sensorimotor adaptation to formant feedback perturbations.
The Journal of the Acoustical Society of America 2021 Raharjo I, Kothare H, Nagarajan SS, Houde JF -
Sensorimotor adaptation of speech depends on the direction of auditory feedback alteration.
The Journal of the Acoustical Society of America 2020 Kothare H, Raharjo I, Ramanarayanan V, Ranasinghe K, Parrell B, Johnson K, Houde JF, Nagarajan SS -
Taking the sublexical route: brain dynamics of reading in the semantic variant of primary progressive aphasia.
Brain : a journal of neurology 2020 Borghesani V, Hinkley LBN, Ranasinghe KG, Thompson MMC, Shwe W, Mizuiri D, Lauricella M, Europa E, Honma S, Miller Z, Miller B, Vossel K, Henry MML, Houde JF, Gorno-Tempini ML, Nagarajan SS -
The Visual Word Form Area compensates for auditory working memory dysfunction in schizophrenia.
Scientific reports 2020 Herman AB, Brown EG, Dale CL, Hinkley LB, Subramaniam K, Houde JF, Fisher M, Vinogradov S, Nagarajan SS -
Optimizing Magnetoencephalographic Imaging Estimation of Language Lateralization for Simpler Language Tasks.
Frontiers in human neuroscience 2020 Hinkley LBN, De Witte E, Cahill-Thompson M, Mizuiri D, Garrett C, Honma S, Findlay A, Gorno-Tempini ML, Tarapore P, Kirsch HE, Mariën P, Houde JF, Berger M, Nagarajan SS -
Learning and adaptation in speech production without a vocal tract.
Scientific reports 2019 Thompson MMC, Houde JF, Nagarajan SS -
The FACTS model of speech motor control: Fusing state estimation and task-based control.
PLoS computational biology 2019 Parrell B, Ramanarayanan V, Nagarajan S, Houde J -
Modeling the Role of Sensory Feedback in Speech Motor Control and Learning.
Journal of speech, language, and hearing research : JSLHR 2019 Parrell B, Houde J -
Cortical-Basal Ganglia-Cerebellar Networks in Unilateral Vocal Fold Paralysis: A Pilot Study.
The Laryngoscope 2019 Perez PL, Cueva KL, Rosen CA, Young VN, Naunheim ML, Yung KC, Schneider SL, Mizuiri D, Klein DJ, Houde JF, Hinkley LB, Nagarajan SS, Cheung SW -
Beta-band activity in medial prefrontal cortex predicts source memory encoding and retrieval accuracy.
Scientific reports 2019 Subramaniam K, Hinkley LBN, Mizuiri D, Kothare H, Cai C, Garrett C, Findlay A, Houde JF, Nagarajan SS -
Abnormally increased vocal responses to pitch feedback perturbations in patients with cerebellar degeneration.
The Journal of the Acoustical Society of America 2019 Houde JF, Gill JS, Agnew Z, Kothare H, Hickok G, Parrell B, Ivry RB, Nagarajan SS -
Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.
Scientific reports 2019 Ranasinghe KG, Kothare H, Kort N, Hinkley LB, Beagle AJ, Mizuiri D, Honma SM, Lee R, Miller BL, Gorno-Tempini ML, Vossel KA, Houde JF, Nagarajan SS -
Cortical networks for speech motor control in unilateral vocal fold paralysis.
The Laryngoscope 2018 Naunheim ML, Yung KC, Schneider SL, Henderson-Sabes J, Kothare H, Hinkley LB, Mizuiri D, Klein DJ, Houde JF, Nagarajan SS, Cheung SW -
Vocal motor control and central auditory impairments in unilateral vocal fold paralysis.
The Laryngoscope 2018 Naunheim ML, Yung KC, Schneider SL, Henderson-Sabes J, Kothare H, Mizuiri D, Klein DJ, Houde JF, Nagarajan SS, Cheung SW -
Online Adaptation to Altered Auditory Feedback Is Predicted by Auditory Acuity and Not by Domain-General Executive Control Resources.
Frontiers in human neuroscience 2018 Martin CD, Niziolek CA, Duñabeitia JA, Perez A, Hernandez D, Carreiras M, Houde JF -
Reality Monitoring and Feedback Control of Speech Production Are Related Through Self-Agency.
Frontiers in human neuroscience 2018 Subramaniam K, Kothare H, Mizuiri D, Nagarajan SS, Houde JF -
Abnormal Speech Motor Control in Individuals with 16p11.2 Deletions.
Scientific reports 2018 Demopoulos C, Kothare H, Mizuiri D, Henderson-Sabes J, Fregeau B, Tjernagel J, Houde JF, Sherr EH, Nagarajan SS -
Distinct spatiotemporal patterns of neuronal functional connectivity in primary progressive aphasia variants.
Brain : a journal of neurology 2017 Ranasinghe KG, Hinkley LB, Beagle AJ, Mizuiri D, Honma SM, Welch AE, Hubbard I, Mandelli ML, Miller ZA, Garrett C, La A, Boxer AL, Houde JF, Miller BL, Vossel KA, Gorno-Tempini ML, Nagarajan SS -
Impaired Feedforward Control and Enhanced Feedback Control of Speech in Patients with Cerebellar Degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Parrell B, Agnew Z, Nagarajan S, Houde J, Ivry RB -
Sensorimotor adaptation affects perceptual compensation for coarticulation.
The Journal of the Acoustical Society of America 2017 Schuerman WL, Nagarajan S, McQueen JM, Houde J -
Abnormal vocal behavior predicts executive and memory deficits in Alzheimer's disease.
Neurobiology of aging 2017 Ranasinghe KG, Gill JS, Kothare H, Beagle AJ, Mizuiri D, Honma SM, Gorno-Tempini ML, Miller BL, Vossel KA, Nagarajan SS, Houde JF -
Bihemispheric network dynamics coordinating vocal feedback control.
Human brain mapping 2016 Kort NS, Cuesta P, Houde JF, Nagarajan SS -
The cortical computations underlying feedback control in vocal production.
Current opinion in neurobiology 2015 Houde JF, Chang EF -
Vowel generation for children with cerebral palsy using myocontrol of a speech synthesizer.
Frontiers in human neuroscience 2015 Niu CM, Lee K, Houde JF, Sanger TD -
Optimal timing of pulse onset for language mapping with navigated repetitive transcranial magnetic stimulation.
NeuroImage 2014 Krieg SM, Tarapore PE, Picht T, Tanigawa N, Houde J, Sollmann N, Meyer B, Vajkoczy P, Berger MS, Ringel F, Nagarajan S -
Simulating a state feedback model of speaking
Proceedings of the 10th International Seminar on Speech Production 2014 Houde JF, Niziolek C, Kort N, Agnew Z, & Nagarajan SS. -
Auditory cortex processes variation in our own speech.
PloS one 2013 Sitek KR, Mathalon DH, Roach BJ, Houde JF, Niziolek CA, Ford JM -
What does motor efference copy represent? Evidence from speech production.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Niziolek CA, Nagarajan SS, Houde JF -
A bilateral cortical network responds to pitch perturbations in speech feedback.
NeuroImage 2013 Kort NS, Nagarajan SS, Houde JF -
Language mapping with navigated repetitive TMS: proof of technique and validation.
NeuroImage 2013 Tarapore PE, Findlay AM, Honma SM, Mizuiri D, Houde JF, Berger MS, Nagarajan SS -
Parsing the phonological loop: activation timing in the dorsal speech stream determines accuracy in speech reproduction.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Herman AB, Houde JF, Vinogradov S, Nagarajan SS -
Human cortical sensorimotor network underlying feedback control of vocal pitch.
Proceedings of the National Academy of Sciences of the United States of America 2013 Chang EF, Niziolek CA, Knight RT, Nagarajan SS, Houde JF -
A right-lateralized cortical network drives error correction to voice pitch feedback perturbation
Journal of the Acoustical Society of America 2013 Kort N, Nagarajan SS, & Houde JF -
Feedback-driven corrective movements in speech in the absence of altered feedback
Journal of the Acoustical Society of America 2013 Niziolek CA, Nagarajan SS, & Houde JF -
Neural evidence for state feedback control of speaking
Proceedings of Meetings on Acoustics 2013 Houde JF, Kort NS, Niziolek CA, Chang EF, & Nagarajan SS. -
Partial compensation for altered auditory feedback: a tradeoff with somatosensory feedback?
Language and speech 2012 Katseff S, Houde J, Johnson K -
Dynamics of hemispheric dominance for language assessed by magnetoencephalographic imaging.
Annals of neurology 2012 Findlay AM, Ambrose JB, Cahn-Weiner DA, Houde JF, Honma S, Hinkley LB, Berger MS, Nagarajan SS, Kirsch HE -
Speech production as state feedback control.
Frontiers in human neuroscience 2011 Houde JF, Nagarajan SS -
Sensorimotor integration in speech processing: computational basis and neural organization.
Neuron 2011 Hickok G, Houde J, Rong F -
There's more to speech perception than meets the ear.
Proceedings of the National Academy of Sciences of the United States of America 2009 Houde JF -
Speech target modulates speaking induced suppression in auditory cortex.
BMC neuroscience 2009 Ventura MI, Nagarajan SS, Houde JF -
Autism overflows with syntheses.
Neuropsychology review 2009 Belmonte MK, Bonneh YS, Adini Y, Iversen PE, Akshoomoff NA, Kenet T, Moore CI, Simon HJ, Houde JF, Merzenich MM -
Motor-induced suppression of the auditory cortex.
Journal of cognitive neuroscience 2009 Aliu SO, Houde JF, Nagarajan SS -
Cross-modal extinction in a boy with severely autistic behaviour and high verbal intelligence.
Cognitive neuropsychology 2008 Bonneh YS, Belmonte MK, Pei F, Iversen PE, Kenet T, Akshoomoff N, Adini Y, Simon HJ, Moore CI, Houde JF, Merzenich MM -
Relationship of imprecise corollary discharge in schizophrenia to auditory hallucinations.
Archives of general psychiatry 2007 Heinks-Maldonado TH, Mathalon DH, Houde JF, Gray M, Faustman WO, Ford JM -
Dynamic cortical imaging of speech compensation for auditory feedback perturbations
Journal of the Acoustical Society of America 2007 Houde JF, Nagarajan SS, & Heinks-Maldonado, T. -
How is auditory feedback processed during speaking?
Journal of the Acoustical Society of America 2007 Houde JF, & Nagarajan SS. -
Magnetoencephalographic evidence for a precise forward model in speech production.
Neuroreport 2006 Heinks-Maldonado TH, Nagarajan SS, Houde JF -
Compensatory responses to brief perturbations of speech amplitude
Acoustics Research Letters Online 2005 Heinks-Maldonado TH, & Houde JF. -
The effect of spectral manipulations on the identification of affective and linguistic prosody.
Brain and language 2003 Lakshminarayanan K, Ben Shalom D, van Wassenhove V, Orbelo D, Houde J, Poeppel D -
Modulation of the auditory cortex during speech: an MEG study.
Journal of cognitive neuroscience 2002 Houde JF, Nagarajan SS, Sekihara K, Merzenich MM -
Sensorimotor adaptation of speech I: Compensation and adaptation.
Journal of speech, language, and hearing research : JSLHR 2002 Houde JF, Jordan MI -
Magnetic field responses of auditory cortex to produced speech
Journal of the Acoustical Society of America 1999 Nagarajan SS, Houde JF, & Merzenich MM. -
Sensorimotor adaptation in speech production.
Science (New York, N.Y.) 1998 Houde JF, Jordan MI -
Adaptation in speech motor control
In Jordan MI, Kearns MJ, and Solla SA (Eds.), Adavances in Neural Information Processing Systems (NIPS) 10 1998 Houde JF, & Jordan MI -
Bone mineral density and broadband ultrasound attenuation with estrogen treatment of postmenopausal women.
Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry 1998 Balikian P, Burbank K, Houde J, Crane G, Nairus J, Ahmadi S, Baran DT -
Correlations among bone mineral density, broadband ultrasound attenuation, mechanical indentation testing, and bone orientation in bovine femoral neck samples.
Calcified tissue international 1997 Duquette J, Lin J, Hoffman A, Houde J, Ahmadi S, Baran D -
Correlation of bone mineral density and femoral neck hardness in bovine and human samples.
Calcified tissue international 1995 Houde J, Marchetti M, Duquette J, Hoffman A, Steinberg G, Crane GK, Baran D -
Adaptation in speech production to transformed auditory feedback
Journal of the Acoustical Society of America 1995 Houde JF, & Jordan MI -
The complete pattern of ocular dominance stripes in the striate cortex and visual field of the macaque monkey.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1985 LeVay S, Connolly M, Houde J, Van Essen DC