John Greenland, MD, PhD
Associate Professor
Medicine
School of Medicine

He serves as an attending physician in the intensive care unit, pulmonary consult service, and outpatient pulmonary clinic at the SF VAHCS. He is an Associate Editor for the American Journal of Transplantation and serves on the programming committee for the International Society for Heart and Lung Transplantation.

His research is focused on improving outcomes following lung transplantation. His group demonstrated that airway brush gene expression patterns can identify lung transplant recipients who at risk for graft failure or death. This novel diagnostic tool has substantial advantages over standard of care approaches and may accelerate clinical trials and personalize therapies to preserve the transplanted lung. His work has also uncovered novel patterns of rejection, including epithelial cell reprogramming, dysbiosis, and activation of T and Natural Killer cells in the airways of transplant recipients.

This research leverages a large bio-repository for cellular immunology, genomic, epigenetic, and bulk and single cell transcriptomic techniques, as well as mouse models to understand airway infections, acute and chronic lung transplant rejection, with a goal of improving outcomes following lung transplantation.

• CCR5 drives NK cell-associated airway damage in pulmonary ischemia-reperfusion injury.
  JCI insight 2023 Santos J, Wang P, Shemesh A, Liu F, Tsao T, Aguilar OA, Cleary SJ, Singer JP, Gao Y, Hays SR, Golden JA, Leard L, Kleinhenz ME, Kolaitis NA, Shah R, Venado A, Kukreja J, Weigt SS, Belperio JA, Lanier …
• The 2022 Banff Meeting Lung Report.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 Pavlisko EN, Adam BA, Berry GJ, Calabrese F, Cortes-Santiago N, Glass CH, Goddard M, Greenland JR, Kreisel D, Levine DJ, Martinu T, Verleden SE, Weigt SS, Roux A
• A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling.
  iScience 2023 Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, …
• Short airway telomeres are associated with primary graft dysfunction and chronic lung allograft dysfunction.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023 Greenland JR, Guo R, Lee S, Tran L, Kapse B, Kukreja J, Hays SR, Golden JA, Calabrese DR, Singer JP, Wolters PJ
• Decreased Lymphocytic Bronchitis Severity in the Era of Azithromycin Prophylaxis.
  Transplantation direct 2023 Santos J, Hays SR, Golden JA, Calabrese DR, Kolaitis N, Kleinhenz ME, Shah R, Estrada AV, Leard LE, Kukreja J, Singer JP, Greenland JR
• Theseus and the search for an antibody-mediated rejection molecular state in lung transplant biopsies.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 Calabrese DR, Greenland JR
• Human galectin-9 potently enhances SARS-CoV-2 replication and inflammation in airway epithelial cells.
  Journal of molecular cell biology 2023 Du L, Bouzidi MS, Gala A, Deiter F, Billaud JN, Yeung ST, Dabral P, Jin J, Simmons G, Dossani ZY, Niki T, Ndhlovu LC, Greenland JR, Pillai SK
• Biofire pneumonia panel in lung donors: faster detection but limited pathogens.
  Transplant infectious disease : an official journal of the Transplantation Society 2023 Nguyen A, Chen J, Isaza E, Panchal N, Deiter F, Hoover J, Trinh B, Hays SR, Golden JA, Singer JP, Brzezinski M, Greenland JR, Kukreja J
• The Association Between Frailty and Chronic Lung Allograft Dysfunction After Lung Transplantation.
  Transplantation 2023 Singer JP, Gao Y, Huang CY, Kordahl RC, Sriram A, Hays SR, Kukreja J, Venado A, Calabrese DR, Greenland JR
• A Novel Viral Assembly Inhibitor Blocks SARS-CoV-2 Replication in Airway Epithelial Cells.
  Research square 2023 Pillai S, Du L, Deiter F, Bouzidi M, Billaud JN, Graham S, Prerna D, Selvarajah S, Lingappa A, Michon M, Yu S, Paulvannan K, Lingappa V, Boushey H, Greenland J
• Development of the Lung Transplant Frailty Scale (LT-FS).
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023 Singer JP, Christie JD, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Arcasoy SM, Lederer DJ, Calabrese D, Wang P, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard LE, Shah RJ, Kleinhenz ME, Golden J,…
• Subphenotypes of frailty in lung transplant candidates.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 Singer JP, Calfee CS, Delucchi K, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Wang P, Arcasoy SM, Lederer DJ, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard LE, Shah RJ, Kleinhenz ME, Golden J, …
• Design and implementation of a digital health home spirometry intervention for remote monitoring of lung transplant function.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023 Odisho AY, Liu AW, Maiorano AR, Bigazzi MOA, Medina E, Leard LE, Shah R, Venado A, Perez A, Golden J, Kleinhenz ME, Kolaitis NA, Maheshwari J, Trinh BN, Kukreja J, Greenland J, Calabrese D, Neinstein …
• CD16+ natural killer cells in bronchoalveolar lavage are associated with antibody-mediated rejection and chronic lung allograft dysfunction.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 Calabrese DR, Chong T, Singer JP, Rajalingam R, Hays SR, Kukreja J, Leard L, Golden JA, Lanier LL, Greenland JR
• Frailty and genetic risk predict fracture after lung transplantation.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 Macrae TA, Lazo J, Viduya J, Florez R, Dewey K, Gao Y, Singer JP, Hays SR, Golden JA, Kukreja J, Greenland JR, Calabrese DR
• NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes.
  JCI insight 2022 Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, …
• Selective decrease of donor-reactive Tregs after liver transplantation limits Treg therapy for promoting allograft tolerance in humans.
  Science translational medicine 2022 Tang Q, Leung J, Peng Y, Sanchez-Fueyo A, Lozano JJ, Lam A, Lee K, Greenland JR, Hellerstein M, Fitch M, Li KW, Esensten JH, Putnam AL, Lares A, Nguyen V, Liu W, Bridges ND, Odim J, Demetris AJ, …
• Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression.
  The Journal of experimental medicine 2022 Shemesh A, Su Y, Calabrese DR, Chen D, Arakawa-Hoyt J, Roybal KT, Heath JR, Greenland JR, Lanier LL
• Contemporary trends in PGD incidence, outcomes, and therapies.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2022 Cantu E, Diamond JM, Cevasco M, Suzuki Y, Crespo M, Clausen E, Dallara L, Ramon CV, Harmon MT, Bermudez C, Benvenuto L, Anderson M, Wille KM, Weinacker A, Dhillon GS, Orens J, Shah P, Merlo C, Lama V,…
• Lymphocytic Airway Inflammation in Lung Allografts.
  Frontiers in immunology 2022 Santos J, Calabrese DR, Greenland JR
• Editorial: Immune Aging: Implications for Transplantation.
  Frontiers in immunology 2022 Greenland JR, Tullius SG, Schaenman J
• Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation in Airway Epithelial Cells.
  bioRxiv : the preprint server for biology 2022 Du L, Bouzidi MS, Gala A, Deiter F, Billaud JN, Yeung ST, Dabral P, Jin J, Simmons G, Dossani Z, Niki T, Ndhlovu LC, Greenland JR, Pillai SK
• Chronic Lung Allograft Dysfunction.
  Thoracic surgery clinics 2022 Venado A, Kukreja J, Greenland JR
• The Intersection of Aging and Lung Transplantation: its Impact on Transplant Evaluation, Outcomes, and Clinical Care.
  Current transplantation reports 2022 Koons B, Anderson MR, Smith PJ, Greenland JR, Singer JP
• Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression.
  The Journal of clinical investigation 2022 Valet C, Magnen M, Qiu L, Cleary SJ, Wang KM, Ranucci S, Grockowiak E, Boudra R, Conrad C, Seo Y, Calabrese DR, Greenland JR, Leavitt AD, Passegué E, Méndez-Ferrer S, Swirski FK, Looney MR
• Depressive symptoms in lung transplant recipients: trajectory and association with mortality and allograft dysfunction.
  Thorax 2022 Kolaitis NA, Gao Y, Soong A, Greenland JR, Hays SR, Golden JA, Venado A, Leard LE, Shah RJ, Kleinhenz ME, Katz PP, Kukreja J, Blanc PD, Smith PJ, Singer JP
• HLA-G/ILT2 signaling on the path to tolerance.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2022 Wang P, Greenland JR
• Inflammation on bronchoalveolar lavage cytology is associated with decreased chronic lung allograft dysfunction-free survival.
  Clinical transplantation 2022 Greenland NY, Deiter F, Calabrese DR, Hays SR, Kukreja J, Leard LE, Kolaitis NA, Golden JA, Singer JP, Greenland JR
• Molecular diagnostics for CLAD: When and where?
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2022 Greenland JR, McDyer JF
• Lung transplant recipients with idiopathic pulmonary fibrosis have impaired alloreactive immune responses.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2021 Wang P, Leung J, Lam A, Lee S, Calabrese DR, Hays SR, Golden JA, Kukreja J, Singer JP, Wolters PJ, Tang Q, Greenland JR
• Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction.
  Frontiers in immunology 2021 Dugger DT, Calabrese DR, Gao Y, Deiter F, Tsao T, Maheshwari J, Hays SR, Leard L, Kleinhenz ME, Shah R, Golden J, Kukreja J, Gordon ED, Singer JP, Greenland JR
• Construct and Predictive Validity of Sarcopenia in Lung Transplant Candidates.
  Annals of the American Thoracic Society 2021 Maheshwari JA, Kolaitis NA, Anderson MR, Benvenuto L, Gao Y, Katz PP, Greenland J, Wolters PJ, Covinsky K, Hays SR, Kukreja J, Calabrese DR, Venado A, Shah RJ, Leard LE, Trinh B, Huang CY, Glidden D, …
• Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19.
  Science translational medicine 2021 van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, …
• The association of post-operative delirium with patient-reported outcomes and mortality after lung transplantation.
  Clinical transplantation 2021 DeBolt CL, Gao Y, Sutter N, Soong A, Leard L, Jeffrey G, Kleinhenz ME, Calabrese D, Greenland J, Venado A, Hays SR, Shah R, Kukreja J, Trinh B, Kolaitis NA, Douglas V, Diamond JM, Smith P, Singer J
• Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19: Anti-IFN antibodies in critical COVID-19 correlate with poor ISG response and upregulation of LAIR1 surface protein in PBMCs.
  bioRxiv : the preprint server for biology 2021 van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, …
• Rapid molecular detection of airway pathogens in lung transplant recipients.
  Transplant infectious disease : an official journal of the Transplantation Society 2021 Hoover J, Mintz MA, Deiter F, Aminian E, Chen J, Hays SR, Singer JP, Calabrese DR, Kukreja J, Greenland JR
• Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury.
  The Journal of clinical investigation 2021 Calabrese DR, Aminian E, Mallavia B, Liu F, Cleary SJ, Aguilar OA, Wang P, Singer JP, Hays SR, Golden JA, Kukreja J, Dugger D, Nakamura M, Lanier LL, Looney MR, Greenland JR
• Frailty and aging-associated syndromes in lung transplant candidates and recipients.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Schaenman JM, Diamond JM, Greenland JR, Gries C, Kennedy CC, Parulekar AD, Rozenberg D, Singer JP, Singer LG, Snyder LD, Bhorade S
• Type-1 immunity and endogenous immune regulators predominate in the airway transcriptome during chronic lung allograft dysfunction.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Iasella CJ, Hoji A, Popescu I, Wei J, Snyder ME, Zhang Y, Xu W, Iouchmanov V, Koshy R, Brown M, Fung M, Langelier C, Lendermon EA, Dugger D, Shah R, Lee J, Johnson B, Golden J, Leard LE, Ellen …
• Complement activation on endothelium initiates antibody-mediated acute lung injury.
  The Journal of clinical investigation 2020 Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR
• Transcriptome-based diagnostics for chronic lung allograft dysfunction: A socratic question revisited.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2020 Greenland JR
• The impact of belatacept on the phenotypic heterogeneity of renal T cell-mediated alloimmune response: The critical role of maintenance treatment and inflammatory load.
  Clinical transplantation 2020 Dobi D, Vincenti F, Chandran S, Greenland JR, Bowman C, Chen A, Junger H, Laszik ZG
• Airway Epithelial Telomere Dysfunction Drives Remodeling Similar to Chronic Lung Allograft Dysfunction.
  American journal of respiratory cell and molecular biology 2020 Naikawadi RP, Green G, Jones KD, Achtar-Zadeh N, Mieleszko JE, Arnould I, Kukreja J, Greenland JR, Wolters PJ
• Chronic lung allograft dysfunction small airways reveal a lymphocytic inflammation gene signature.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Dugger DT, Fung M, Hays SR, Singer JP, Kleinhenz ME, Leard LE, Golden JA, Shah RJ, Lee JS, Deiter F, Greenland NY, Jones KD, Langelier CR, Greenland JR
• Primary graft dysfunction attenuates improvements in health-related quality of life after lung transplantation, but not disability or depression.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Kolaitis NA, Gao Y, Soong A, Greenland JR, Hays SR, Golden J, Leard LE, Shah RJ, Kleinhenz ME, Katz PP, Venado A, Kukreja J, Blanc PD, Singer JP
• COVID-19 Infection: Perioperative Implications: Reply.
  Anesthesiology 2020 Greenland JR, Michelow MD, Wang L, London MJ
• Cystic Fibrosis Lung Transplant Recipients Have Suppressed Airway Interferon Responses during Pseudomonas Infection.
  Cell reports. Medicine 2020 Dugger DT, Fung M, Zlock L, Caldera S, Sharp L, Hays SR, Singer JP, Leard LE, Golden JA, Shah RJ, Kukreja J, Gordon E, Finkbeiner W, Kleinhenz ME, Langelier C, Greenland JR
• International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2020 Martinu T, Koutsokera A, Benden C, Cantu E, Chambers D, Cypel M, Edelman J, Emtiazjoo A, Fisher AJ, Greenland JR, Hayes D, Hwang D, Keller BC, Lease ED, Perch M, Sato M, Todd JL, Verleden S, von der …
• COVID-19 Infection: Implications for Perioperative and Critical Care Physicians.
  Anesthesiology 2020 Greenland JR, Michelow MD, Wang L, London MJ
• Skeletal muscle adiposity and outcomes in candidates for lung transplantation: a lung transplant body composition cohort study.
  Thorax 2020 Anderson MR, Easthausen I, Gallagher G, Udupa J, Tong Y, Torigian D, Diamond JM, Porteous MK, Palmer SM, Snyder LD, Benvenuto L, Aversa M, Arcasoy S, Greenland JR, Hays SR, Kukreja J, Cantu E, Kim JS,…
• Frailty after lung transplantation is associated with impaired health-related quality of life and mortality.
  Thorax 2020 Venado A, Kolaitis NA, Huang CY, Gao Y, Glidden DV, Soong A, Sutter N, Katz PP, Greenland JR, Calabrese DR, Hays SR, Golden JA, Shah RJ, Leard LE, Kukreja J, Deuse T, Wolters PJ, Covinsky K, Blanc PD,…
• Pathobiology of frailty in lung disease.
  Translational research : the journal of laboratory and clinical medicine 2020 Koons B, Greenland JR, Diamond JM, Singer JP
• Improvements in frailty contribute to substantial improvements in quality of life after lung transplantation in patients with cystic fibrosis.
  Pediatric pulmonology 2020 Perez AA, Hays SR, Soong A, Gao Y, Greenland JR, Leard LE, Shah RJ, Golden J, Kukreja J, Venado A, Kleinhenz ME, Singer JP
• Tacrolimus trough monitoring guided by mass spectrometry without accounting for assay differences is associated with acute kidney injury in lung transplant recipients.
  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2019 Kolaitis NA, Calabrese DR, Ahearn P, Venado A, Florez R, Lei HL, Isaak K, Henricksen E, Martinez E, Chong T, Shah RJ, Leard LE, Kleinhenz ME, Golden J, De Marco T, Greenland JR, Kukreja J, Hays SR, …
• Dectin-1 genetic deficiency predicts chronic lung allograft dysfunction and death.
  JCI insight 2019 Calabrese DR, Wang P, Chong T, Hoover J, Singer JP, Torgerson D, Hays SR, Golden JA, Kukreja J, Dugger D, Christie JD, LTOG investigators, Greenland JR
• Adipose tissue quantification and primary graft dysfunction after lung transplantation: The Lung Transplant Body Composition study.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2019 Anderson MR, Udupa JK, Edwin E, Diamond JM, Singer JP, Kukreja J, Hays SR, Greenland JR, Ferrante A, Lippel M, Blue T, McBurnie A, Oyster M, Kalman L, Rushefski M, Wu C, Pednekar G, Liu W, Arcasoy S, …
• A nonlinear relationship between visceral adipose tissue and frailty in adult lung transplant candidates.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2019 Anderson MR, Kolaitis NA, Gao Y, Kukreja J, Greenland J, Hays S, Wolters P, Golden J, Diamond J, Palmer S, Arcasoy S, Udupa J, Christie JD, Lederer DJ, Singer JP
• Management and clinical outcomes after lung transplantation in patients with pre-transplant Mycobacterium abscessus infection: A single center experience.
  Transplant infectious disease : an official journal of the Transplantation Society 2019 Perez AA, Singer JP, Schwartz BS, Chin-Hong P, Shah RJ, Kleinhenz ME, Gao Y, Venado A, Leard LE, Golden JA, Kukreja J, Greenland JR, Hays SR
• Development and Preliminary Validation of the Lung Transplant Quality of Life (LT-QOL) Survey.
  American journal of respiratory and critical care medicine 2019 Singer JP, Soong A, Chen J, Shrestha P, Zhuo H, Gao Y, Greenland JR, Hays SR, Kukreja J, Golden J, Gregorich SE, Stewart AL
• Gene signatures common to allograft rejection are associated with lymphocytic bronchitis.
  Clinical transplantation 2019 Greenland JR, Wang P, Brotman JJ, Ahuja R, Chong TA, Kleinhenz ME, Leard LE, Golden JA, Hays SR, Kukreja J, Singer JP, Rajalingam R, Jones K, Laszik ZG, Trivedi NN, Greenland NY, Blanc PD
• Frailty trajectories in adult lung transplantation: A cohort study.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2019 Venado A, McCulloch C, Greenland JR, Katz P, Soong A, Shrestha P, Hays S, Golden J, Shah R, Leard LE, Kleinhenz ME, Kukreja J, Zablotska L, Allen IE, Covinsky K, Blanc P, Singer JP
• NKG2C Natural Killer Cells in Bronchoalveolar Lavage Are Associated With Cytomegalovirus Viremia and Poor Outcomes in Lung Allograft Recipients.
  Transplantation 2019 Calabrese DR, Chong T, Wang A, Singer JP, Gottschall M, Hays SR, Golden JA, Kukreja J, Lanier LL, Tang Q, Greenland JR
• Where the Chromosome Ends: Telomeres and Cytomegalovirus Risk in Lung Transplant Recipients.
  American journal of respiratory and critical care medicine 2019 Greenland JR
• Natural killer cells in lung transplantation.
  Thorax 2018 Calabrese DR, Lanier LL, Greenland JR
• Genotypes associated with tacrolimus pharmacokinetics impact clinical outcomes in lung transplant recipients.
  Clinical transplantation 2018 Calabrese DR, Florez R, Dewey K, Hui C, Torgerson D, Chong T, Faust H, Rajalingam R, Hays SR, Golden JA, Kukreja J, Singer JP, Greenland JR
• A mobile health technology enabled home-based intervention to treat frailty in adult lung transplant candidates: A pilot study.
  Clinical transplantation 2018 Singer JP, Soong A, Bruun A, Bracha A, Chin G, Hays SR, Kukreja J, Rigler J, Golden JA, Greenland JR, Garvey C
• Suppressed calcineurin-dependent gene expression identifies lung allograft recipients at increased risk of infection.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2018 Greenland JR, Chong T, Wang AS, Martinez E, Shrestha P, Kukreja J, Hays SR, Golden JA, Singer JP, Tang Q
• Frailty phenotypes and mortality after lung transplantation: A prospective cohort study.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2018 Singer JP, Diamond JM, Anderson MR, Katz PP, Covinsky K, Oyster M, Blue T, Soong A, Kalman L, Shrestha P, Arcasoy SM, Greenland JR, Shah L, Kukreja J, Blumenthal NP, Easthausen I, Golden JA, McBurnie …
• Improvement in patient-reported outcomes after lung transplantation is not impacted by the use of extracorporeal membrane oxygenation as a bridge to transplantation.
  The Journal of thoracic and cardiovascular surgery 2018 Kolaitis NA, Soong A, Shrestha P, Zhuo H, Neuhaus J, Katz PP, Greenland JR, Golden J, Leard LE, Shah RJ, Hays SR, Kukreja J, Kleinhenz ME, Blanc PD, Singer JP
• Refining Low Physical Activity Measurement Improves Frailty Assessment in Advanced Lung Disease and Survivors of Critical Illness.
  Annals of the American Thoracic Society 2017 Baldwin MR, Singer JP, Huang D, Sell J, Gonzalez WC, Pollack LR, Maurer MS, D'Ovidio FF, Bacchetta M, Sonett JR, Arcasoy SM, Shah L, Robbins H, Hays SR, Kukreja J, Greenland JR, Shah RJ, Leard L, …
• HLA Mismatching Favoring Host-Versus-Graft NK Cell Activity Via KIR3DL1 Is Associated With Improved Outcomes Following Lung Transplantation.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2017 Greenland JR, Sun H, Calabrese D, Chong T, Singer JP, Kukreja J, Hays SR, Golden JA, Caughey GH, Venstrom JM, Rajalingam R
• Short lung transplant donor telomere length is associated with decreased CLAD-free survival.
  Thorax 2017 Faust HE, Golden JA, Rajalingam R, Wang AS, Green G, Hays SR, Kukreja J, Singer JP, Wolters PJ, Greenland JR
• Effect of Lung Transplantation on Health-Related Quality of Life in the Era of the Lung Allocation Score: A U.S. Prospective Cohort Study.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2017 Singer JP, Katz PP, Soong A, Shrestha P, Huang D, Ho J, Mindo M, Greenland JR, Hays SR, Golden J, Kukreja J, Kleinhenz ME, Shah RJ, Blanc PD
• Cathepsin L Helps to Defend Mice from Infection with Influenza A.
  PloS one 2016 Xu X, Greenland JR, Gotts JE, Matthay MA, Caughey GH
• Donor-Reactive Regulatory T Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts.
  Transplantation 2016 Greenland JR, Wong CM, Ahuja R, Wang AS, Uchida C, Golden JA, Hays SR, Leard LE, Rajalingam R, Singer JP, Kukreja J, Wolters PJ, Caughey GH, Tang Q
• Frailty Phenotypes, Disability, and Outcomes in Adult Candidates for Lung Transplantation.
  American journal of respiratory and critical care medicine 2015 Singer JP, Diamond JM, Gries CJ, McDonnough J, Blanc PD, Shah R, Dean MY, Hersh B, Wolters PJ, Tokman S, Arcasoy SM, Ramphal K, Greenland JR, Smith N, Heffernan P, Shah L, Shrestha P, Golden JA, …
• Lung transplantation for hypersensitivity pneumonitis.
  Chest 2015 Kern RM, Singer JP, Koth L, Mooney J, Golden J, Hays S, Greenland J, Wolters P, Ghio E, Jones KD, Leard L, Kukreja J, Blanc PD
• Mast cells in a murine lung ischemia-reperfusion model of primary graft dysfunction.
  Respiratory research 2014 Greenland JR, Xu X, Sayah DM, Liu FC, Jones KD, Looney MR, Caughey GH
• Bronchoalveolar lavage cell immunophenotyping facilitates diagnosis of lung allograft rejection.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2014 Greenland JR, Jewell NP, Gottschall M, Trivedi NN, Kukreja J, Hays SR, Singer JP, Golden JA, Caughey GH
• Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis.
  American journal of respiratory cell and molecular biology 2013 Xu X, Greenland J, Baluk P, Adams A, Bose O, McDonald DM, Caughey GH
• Association of large-airway lymphocytic bronchitis with bronchiolitis obliterans syndrome.
  American journal of respiratory and critical care medicine 2012 Greenland JR, Jones KD, Hays SR, Golden JA, Urisman A, Jewell NP, Caughey GH, Trivedi NN
• Non-classical natural killer T cells modulate plasmid DNA vaccine antigen expression and vaccine-elicited immune responses by MCP-1 secretion after interaction with a beta2-microglobulin-independent CD1d.
  The Journal of biological chemistry 2009 Geiben-Lynn R, Greenland JR, Frimpong-Boateng K, Letvin NL
• CD4+ T lymphocytes mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate CD8+ T-cell immune responses.
  Blood 2008 Geiben-Lynn R, Greenland JR, Frimpong-Boateng K, van Rooijen N, Hovav AH, Letvin NL
• Kinetics of recombinant adenovirus type 5, vaccinia virus, modified vaccinia ankara virus, and DNA antigen expression in vivo and the induction of memory T-lymphocyte responses.
  Clinical and vaccine immunology : CVI 2008 Geiben-Lynn R, Greenland JR, Frimpong-Boateng K, Letvin NL
• Effects of type I interferons on the adjuvant properties of plasmid granulocyte-macrophage colony-stimulating factor in vivo.
  Journal of virology 2007 Qin L, Greenland JR, Moriya C, Cayabyab MJ, Letvin NL
• Plasmid DNA vaccine-elicited cellular immune responses limit in vivo vaccine antigen expression through Fas-mediated apoptosis.
  Journal of immunology (Baltimore, Md. : 1950) 2007 Greenland JR, Geiben R, Ghosh S, Pastor WA, Letvin NL
• Chemical adjuvants for plasmid DNA vaccines.
  Vaccine 2007 Greenland JR, Letvin NL
• Rapid memory CD8+ T-lymphocyte induction through priming with recombinant Mycobacterium smegmatis.
  Journal of virology 2006 Hovav AH, Cayabyab MJ, Panas MW, Santra S, Greenland J, Geiben R, Haynes BF, Jacobs WR, Letvin NL
• Beta-amino ester polymers facilitate in vivo DNA transfection and adjuvant plasmid DNA immunization.
  Molecular therapy : the journal of the American Society of Gene Therapy 2005 Greenland JR, Liu H, Berry D, Anderson DG, Kim WK, Irvine DJ, Langer R, Letvin NL
• Mutations in the RNA binding domain of stem-loop binding protein define separable requirements for RNA binding and for histone pre-mRNA processing.
  Molecular and cellular biology 2001 Dominski Z, Erkmann JA, Greenland JA, Marzluff WF