John Forsayeth, PhD
Professor
Neurological Surgery
School of Medicine

Grants and Projects

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• Neuronal Nicotinic Receptor--Assembly and Regulation, NIH, 1993-1996
• Synaptic Assembly in Non-muscle Cells, NIH, 1990-1993

Publications (119)

Top publication keywords:
Genetic VectorsParkinson DiseaseArthralgiaSphingomyelin PhosphodiesteraseGlial Cell Line-Derived Neurotrophic FactorPutamenGene Transfer TechniquesGenetic TherapyInterleukin-10LiposomesDrug Delivery SystemsTransduction, GeneticDependovirusAromatic-L-Amino-Acid DecarboxylasesAntigen-Presenting Cells

• GDNF gene therapy for alcohol use disorder in male non-human primates.
  Nature medicine 2023 Ford MM, George BE, Van Laar VS, Holleran KM, Naidoo J, Hadaczek P, Vanderhooft LE, Peck EG, Dawes MH, Ohno K, Bringas J, McBride JL, Samaranch L, Forsayeth JR, Jones SR, Grant KA, Bankiewicz KS
• Targeted interleukin-10 plasmid DNA therapy in the treatment of osteoarthritis: Toxicology and pain efficacy assessments.
  Brain, behavior, and immunity 2020 Watkins LR, Chavez RA, Landry R, Fry M, Green-Fulgham SM, Coulson JD, Collins SD, Glover DK, Rieger J, Forsayeth JR
• Adeno-associated viral vector serotype 9-based gene therapy for Niemann-Pick disease type A.
  Science translational medicine 2019 Samaranch L, Pérez-Cañamás A, Soto-Huelin B, Sudhakar V, Jurado-Arjona J, Hadaczek P, Ávila J, Bringas JR, Casas J, Chen H, He X, Schuchman EH, Cheng SH, Forsayeth J, Bankiewicz KS, Ledesma MD
• Kinetics and MR-Based Monitoring of AAV9 Vector Delivery into Cerebrospinal Fluid of Nonhuman Primates.
  Molecular therapy. Methods & clinical development 2018 Ohno K, Samaranch L, Hadaczek P, Bringas JR, Allen PC, Sudhakar V, Stockinger DE, Snieckus C, Campagna MV, San Sebastian W, Naidoo J, Chen H, Forsayeth J, Salegio EA, Hwa GGC, Bankiewicz KS
• Extensive Transduction and Enhanced Spread of a Modified AAV2 Capsid in the Non-human Primate CNS.
  Molecular therapy : the journal of the American Society of Gene Therapy 2018 Naidoo J, Stanek LM, Ohno K, Trewman S, Samaranch L, Hadaczek P, O'Riordan C, Sullivan J, San Sebastian W, Bringas JR, Snieckus C, Mahmoodi A, Mahmoodi A, Forsayeth J, Bankiewicz KS, Shihabuddin LS

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• Ganglioside Metabolism and Parkinson's Disease.
  Frontiers in neuroscience 2018 Forsayeth J, Hadaczek P
• Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity.
  Stroke 2017 Zhu W, Shen F, Mao L, Zhan L, Kang S, Sun Z, Nelson J, Zhang R, Zou D, McDougall CM, Lawton MT, Vu TH, Wu Z, Scaria A, Colosi P, Forsayeth J, Su H
• Depletion of AADC activity in caudate nucleus and putamen of Parkinson's disease patients; implications for ongoing AAV2-AADC gene therapy trial.
  PloS one 2017 Ciesielska A, Samaranch L, San Sebastian W, Dickson DW, Goldman S, Forsayeth J, Bankiewicz KS
• Widespread AAV1- and AAV2-mediated transgene expression in the nonhuman primate brain: implications for Huntington's disease.
  Molecular therapy. Methods & clinical development 2016 Hadaczek P, Stanek L, Ciesielska A, Sudhakar V, Samaranch L, Pivirotto P, Bringas J, O'Riordan C, Mastis B, San Sebastian W, Forsayeth J, Cheng SH, Bankiewicz KS, Shihabuddin LS
• Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy.
  Brain, behavior, and immunity 2016 Grace PM, Loram LC, Christianson JP, Strand KA, Flyer-Adams JG, Penzkover KR, Forsayeth JR, van Dam AM, Mahoney MJ, Maier SF, Chavez RA, Watkins LR
• Axonal transport of AAV9 in nonhuman primate brain.
  Gene therapy 2016 Green F, Samaranch L, Zhang HS, Manning-Bog A, Meyer K, Forsayeth J, Bankiewicz KS
• AAV viral vector delivery to the brain by shape-conforming MR-guided infusions.
  Journal of controlled release : official journal of the Controlled Release Society 2016 Bankiewicz KS, Sudhakar V, Samaranch L, San Sebastian W, Bringas J, Forsayeth J
• Cerebellomedullary Cistern Delivery for AAV-Based Gene Therapy: A Technical Note for Nonhuman Primates.
  Human gene therapy methods 2016 Samaranch L, Bringas J, Pivirotto P, Sebastian WS, Forsayeth J, Bankiewicz K
• Self-assembled 20-nm (64)Cu-micelles enhance accumulation in rat glioblastoma.
  Journal of controlled release : official journal of the Controlled Release Society 2015 Seo JW, Ang J, Mahakian LM, Tam S, Fite B, Ingham ES, Beyer J, Forsayeth J, Bankiewicz KS, Xu T, Ferrara KW
• Slow AAV2 clearance from the brain of nonhuman primates and anti-capsid immune response.
  Gene therapy 2015 Samaranch L, Hadaczek P, Kells AP, Bringas JR, Stockinger D, San Sebastian W, Macayan M, Samineni S, Pivirotto P, Forsayeth J, Bankiewicz KS
• Carbidopa-based modulation of the functional effect of the AAV2-hAADC gene therapy in 6-OHDA lesioned rats.
  PloS one 2015 Ciesielska A, Sharma N, Beyer J, Forsayeth J, Bankiewicz K
• Transduction of antigen-presenting cells in the brain by AAV9 warrants caution in preclinical studies.
  Molecular therapy : the journal of the American Society of Gene Therapy 2015 Forsayeth J, Bankiewicz KS
• GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.
  Experimental neurology 2014 Hadaczek P, Wu G, Sharma N, Ciesielska A, Bankiewicz K, Davidow AL, Lu ZH, Forsayeth J, Ledeen RW
• SAFETY AND TOLERABILITY OF MRI-GUIDED INFUSION OF AAV2-hAADC INTO THE MID-BRAIN OF NON-HUMAN PRIMATE.
  Molecular therapy. Methods & clinical development 2014 San Sebastian W, Kells AP, Bringas J, Samaranch L, Hadaczek P, Ciesielska A, Macayan M, Pivirotto PJ, Forsayeth J, Osborne S, Wright JF, Green F, Heller G, Bankiewicz KS
• Peri-tumoral leakage during intra-tumoral convection-enhanced delivery has implications for efficacy of peri-tumoral infusion before removal of tumor.
  Drug delivery 2014 Yang X, Saito R, Nakamura T, Zhang R, Sonoda Y, Kumabe T, Forsayeth J, Bankiewicz K, Tominaga T
• Glial cell line-derived neurotrophic factor (GDNF) is an endogenous protector in the mesolimbic system against excessive alcohol consumption and relapse.
  Addiction biology 2014 Barak S, Wang J, Ahmadiantehrani S, Ben Hamida S, Kells AP, Forsayeth J, Bankiewicz KS, Ron D
• Distribution of nanoparticles throughout the cerebral cortex of rodents and non-human primates: Implications for gene and drug therapy.
  Frontiers in neuroanatomy 2014 Salegio EA, Streeter H, Dube N, Hadaczek P, Samaranch L, Kells AP, San Sebastian W, Zhai Y, Bringas J, Xu T, Forsayeth J, Bankiewicz KS
• Pharmacokinetics, tumor accumulation and antitumor activity of nanoliposomal irinotecan following systemic treatment of intracranial tumors.
  Nanomedicine (London, England) 2014 Noble CO, Krauze MT, Drummond DC, Forsayeth J, Hayes ME, Beyer J, Hadaczek P, Berger MS, Kirpotin DB, Bankiewicz KS, Park JW
• AAV9-mediated expression of a non-self protein in nonhuman primate central nervous system triggers widespread neuroinflammation driven by antigen-presenting cell transduction.
  Molecular therapy : the journal of the American Society of Gene Therapy 2013 Samaranch L, Sebastian WS, Kells AP, Salegio EA, Heller G, Bringas JR, Pivirotto P, DeArmond S, Forsayeth J, Bankiewicz KS
• Evaluation of doxorubicin-loaded 3-helix micelles as nanocarriers.
  Biomacromolecules 2013 Dube N, Shu JY, Dong H, Seo JW, Ingham E, Kheirolomoom A, Chen PY, Forsayeth J, Bankiewicz K, Ferrara KW, Xu T
• Adeno-associated virus type 6 is retrogradely transported in the non-human primate brain.
  Gene therapy 2013 San Sebastian W, Samaranch L, Heller G, Kells AP, Bringas J, Pivirotto P, Forsayeth J, Bankiewicz KS
• Gene therapy for misfolding protein diseases of the central nervous system.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2013 San Sebastian W, Samaranch L, Kells AP, Forsayeth J, Bankiewicz KS
• Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors in a rodent brain tumor model.
  Cancer gene therapy 2013 Yin D, Zhai Y, Gruber HE, Ibanez CE, Robbins JM, Kells AP, Kasahara N, Forsayeth J, Jolly DJ, Bankiewicz KS
• Strong cortical and spinal cord transduction after AAV7 and AAV9 delivery into the cerebrospinal fluid of nonhuman primates.
  Human gene therapy 2013 Samaranch L, Salegio EA, San Sebastian W, Kells AP, Bringas JR, Forsayeth J, Bankiewicz KS
• Comparing routes of delivery for nanoliposomal irinotecan shows superior anti-tumor activity of local administration in treating intracranial glioblastoma xenografts.
  Neuro-oncology 2012 Chen PY, Ozawa T, Drummond DC, Kalra A, Fitzgerald JB, Kirpotin DB, Wei KC, Butowski N, Prados MD, Berger MS, Forsayeth JR, Bankiewicz K, James CD
• Cerebral infusion of AAV9 vector-encoding non-self proteins can elicit cell-mediated immune responses.
  Molecular therapy : the journal of the American Society of Gene Therapy 2012 Ciesielska A, Hadaczek P, Mittermeyer G, Zhou S, Wright JF, Bankiewicz KS, Forsayeth J
• Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain.
  Human gene therapy 2012 Salegio EA, Samaranch L, Jenkins RW, Clarke CJ, Lamarre C, Beyer J, Kells AP, Bringas J, Sebastian WS, Richardson RM, Rosenbluth KH, Hannun YA, Bankiewicz KS, Forsayeth J
• Merits of combination cortical, subcortical, and cerebellar injections for the treatment of Niemann-Pick disease type A.
  Molecular therapy : the journal of the American Society of Gene Therapy 2012 Bu J, Ashe KM, Bringas J, Marshall J, Dodge JC, Cabrera-Salazar MA, Forsayeth J, Schuchman EH, Bankiewicz KS, Cheng SH, Shihabuddin LS, Passini MA
• Long-term evaluation of a phase 1 study of AADC gene therapy for Parkinson's disease.
  Human gene therapy 2012 Mittermeyer G, Christine CW, Rosenbluth KH, Baker SL, Starr P, Larson P, Kaplan PL, Forsayeth J, Aminoff MJ, Bankiewicz KS
• Adeno-associated virus serotype 9 transduction in the central nervous system of nonhuman primates.
  Human gene therapy 2012 Samaranch L, Salegio EA, San Sebastian W, Kells AP, Foust KD, Bringas JR, Lamarre C, Forsayeth J, Kaspar BK, Bankiewicz KS
• Axonal transport of adeno-associated viral vectors is serotype-dependent.
  Gene therapy 2012 Salegio EA, Samaranch L, Kells AP, Mittermeyer G, San Sebastian W, Zhou S, Beyer J, Forsayeth J, Bankiewicz KS
• Systemic rapamycin alone may not be a treatment option for malignant glioma: evidence from an in vivo study.
  Journal of neuro-oncology 2012 Mendiburu-Eliçabe M, Yin D, Hadaczek P, Zhai Y, Forsayeth J, Bankiewicz KS
• Safety and tolerability of magnetic resonance imaging-guided convection-enhanced delivery of AAV2-hAADC with a novel delivery platform in nonhuman primate striatum.
  Human gene therapy 2012 San Sebastian W, Richardson RM, Kells AP, Lamarre C, Bringas J, Pivirotto P, Salegio EA, Dearmond SJ, Forsayeth J, Bankiewicz KS
• Evaluation of an AAV2-based rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system.
  PloS one 2011 Hadaczek P, Beyer J, Kells A, Narrow W, Bowers W, Federoff HJ, Forsayeth J, Bankiewicz KS
• Guided delivery of adeno-associated viral vectors into the primate brain.
  Advanced drug delivery reviews 2011 Salegio EA, Samaranch L, Kells AP, Forsayeth J, Bankiewicz K
• Glial-derived neurotrophic factor gene transfer for Parkinson's disease: anterograde distribution of AAV2 vectors in the primate brain.
  Neurobiology of disease 2011 Kells AP, Forsayeth J, Bankiewicz KS
• AAV9: over the fence and into the woods . . .
  Molecular therapy : the journal of the American Society of Gene Therapy 2011 Forsayeth JR, Bankiewicz KS
• Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease.
  Molecular therapy : the journal of the American Society of Gene Therapy 2011 Richardson RM, Kells AP, Rosenbluth KH, Salegio EA, Fiandaca MS, Larson PS, Starr PA, Martin AJ, Lonser RR, Federoff HJ, Forsayeth JR, Bankiewicz KS
• An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Laganiere J, Kells AP, Lai JT, Guschin D, Paschon DE, Meng X, Fong LK, Yu Q, Rebar EJ, Gregory PD, Bankiewicz KS, Forsayeth J, Zhang HS
• Gene therapy for Parkinson's disease: where are we now and where are we going?
  Expert review of neurotherapeutics 2010 Forsayeth J, Bankiewicz KS, Aminoff MJ
• Anterograde axonal transport of AAV2-GDNF in rat basal ganglia.
  Molecular therapy : the journal of the American Society of Gene Therapy 2010 Ciesielska A, Mittermeyer G, Hadaczek P, Kells AP, Forsayeth J, Bankiewicz KS
• Qualitative imaging of adeno-associated virus serotype 2-human aromatic L-amino acid decarboxylase gene therapy in a phase I study for the treatment of Parkinson disease.
  Neurosurgery 2010 Valles F, Fiandaca MS, Eberling JL, Starr PA, Larson PS, Christine CW, Forsayeth J, Richardson RM, Su X, Aminoff MJ, Bankiewicz KS
• Magnetic resonance imaging-guided delivery of adeno-associated virus type 2 to the primate brain for the treatment of lysosomal storage disorders.
  Human gene therapy 2010 Salegio EA, Kells AP, Richardson RM, Hadaczek P, Forsayeth J, Bringas J, Sardi SP, Passini MA, Shihabuddin LS, Cheng SH, Fiandaca MS, Bankiewicz KS
• Cannula placement for effective convection-enhanced delivery in the nonhuman primate thalamus and brainstem: implications for clinical delivery of therapeutics.
  Journal of neurosurgery 2010 Yin D, Richardson RM, Fiandaca MS, Bringas J, Forsayeth J, Berger MS, Bankiewicz KS
• Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS
• Real-time MR imaging with Gadoteridol predicts distribution of transgenes after convection-enhanced delivery of AAV2 vectors.
  Molecular therapy : the journal of the American Society of Gene Therapy 2010 Su X, Kells AP, Salegio EA, Salegio EA, Richardson RM, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Forsayeth J, Bankiewicz KS
• Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC.
  Molecular therapy : the journal of the American Society of Gene Therapy 2010 Hadaczek P, Eberling JL, Pivirotto P, Bringas J, Forsayeth J, Bankiewicz KS
• Canine spontaneous glioma: a translational model system for convection-enhanced delivery.
  Neuro-oncology 2010 Dickinson PJ, LeCouteur RA, Higgins RJ, Bringas JR, Larson RF, Yamashita Y, Krauze MT, Forsayeth J, Noble CO, Drummond DC, Kirpotin DB, Park JW, Berger MS, Bankiewicz KS
• Pharmacokinetics and bioactivity of glial cell line-derived factor (GDNF) and neurturin (NTN) infused into the rat brain.
  Neuropharmacology 2010 Hadaczek P, Johnston L, Forsayeth J, Bankiewicz KS
• Image-guided convection-enhanced delivery of GDNF protein into monkey putamen.
  NeuroImage 2010 Gimenez F, Krauze MT, Valles F, Hadaczek P, Bringas J, Sharma N, Forsayeth J, Bankiewicz KS
• Optimized cannula design and placement for convection-enhanced delivery in rat striatum.
  Journal of neuroscience methods 2009 Yin D, Forsayeth J, Bankiewicz KS
• Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys.
  Human gene therapy 2009 Su X, Kells AP, Huang EJ, Lee HS, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Penticuff J, Eberling J, Federoff HJ, Forsayeth J, Bankiewicz KS
• Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates.
  NeuroImage 2009 Yin D, Valles FE, Fiandaca MS, Bringas J, Gimenez F, Berger MS, Forsayeth J, Bankiewicz KS
• Anatomic compression caused by high-volume convection-enhanced delivery to the brain.
  Neurosurgery 2009 Valles F, Fiandaca MS, Bringas J, Dickinson P, LeCouteur R, Higgins R, Berger M, Forsayeth J, Bankiewicz KS
• Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys.
  Human gene therapy 2009 Johnston LC, Eberling J, Pivirotto P, Hadaczek P, Federoff HJ, Forsayeth J, Bankiewicz KS
• Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys.
  Human gene therapy 2009 Eberling JL, Kells AP, Pivirotto P, Beyer J, Bringas J, Federoff HJ, Forsayeth J, Bankiewicz KS
• Future applications: gene therapy.
  Neurosurgery clinics of North America 2009 Richardson RM, Varenika V, Forsayeth JR, Bankiewicz KS
• Transduction of nonhuman primate brain with adeno-associated virus serotype 1: vector trafficking and immune response.
  Human gene therapy 2009 Hadaczek P, Forsayeth J, Mirek H, Munson K, Bringas J, Pivirotto P, McBride JL, Davidson BL, Bankiewicz KS
• Efficient gene therapy-based method for the delivery of therapeutics to primate cortex.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Kells AP, Hadaczek P, Yin D, Bringas J, Varenika V, Forsayeth J, Bankiewicz KS
• Controlled dissemination of AAV vectors in the primate brain.
  Progress in brain research 2009 Varenika V, Kells AP, Valles F, Hadaczek P, Forsayeth J, Bankiewicz KS
• Convection-enhanced delivery of liposomes to primate brain.
  Methods in enzymology 2009 Krauze MT, Forsayeth J, Yin D, Bankiewicz KS
• Real-time MR imaging of adeno-associated viral vector delivery to the primate brain.
  NeuroImage 2008 Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS
• Striatal volume differences between non-human and human primates.
  Journal of neuroscience methods 2008 Yin D, Valles FE, Fiandaca MS, Forsayeth J, Larson P, Starr P, Bankiewicz KS
• Engineering GPCR signaling pathways with RASSLs.
  Nature methods 2008 Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL
• Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease.
  Molecular therapy : the journal of the American Society of Gene Therapy 2008 Johnston LC, Su X, Maguire-Zeiss K, Horovitz K, Ankoudinova I, Guschin D, Hadaczek P, Federoff HJ, Bankiewicz K, Forsayeth J
• Image-guided convection-enhanced delivery platform in the treatment of neurological diseases.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2008 Fiandaca MS, Forsayeth JR, Dickinson PJ, Bankiewicz KS
• Safety of real-time convection-enhanced delivery of liposomes to primate brain: a long-term retrospective.
  Experimental neurology 2007 Krauze MT, Vandenberg SR, Yamashita Y, Saito R, Forsayeth J, Noble C, Park J, Bankiewicz KS
• Current status of gene therapy trials for Parkinson's disease.
  Experimental neurology 2007 Fiandaca M, Forsayeth J, Bankiewicz K
• Convection-enhanced delivery of nanoliposomal CPT-11 (irinotecan) and PEGylated liposomal doxorubicin (Doxil) in rodent intracranial brain tumor xenografts.
  Neuro-oncology 2007 Krauze MT, Noble CO, Kawaguchi T, Drummond D, Kirpotin DB, Yamashita Y, Kullberg E, Forsayeth J, Park JW, Bankiewicz KS
• Real-time imaging and quantification of brain delivery of liposomes.
  Pharmaceutical research 2006 Krauze MT, Forsayeth J, Park JW, Bankiewicz KS
• Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC.
  Molecular therapy : the journal of the American Society of Gene Therapy 2006 Bankiewicz KS, Forsayeth J, Eberling JL, Sanchez-Pernaute R, Pivirotto P, Bringas J, Herscovitch P, Carson RE, Eckelman W, Reutter B, Cunningham J
• A dose-ranging study of AAV-hAADC therapy in Parkinsonian monkeys.
  Molecular therapy : the journal of the American Society of Gene Therapy 2006 Forsayeth JR, Eberling JL, Sanftner LM, Zhen Z, Pivirotto P, Bringas J, Cunningham J, Bankiewicz KS
• Distribution of AAV2-hAADC-transduced cells after 3 years in Parkinsonian monkeys.
  Neuroreport 2006 Daadi MM, Pivirotto P, Bringas J, Cunningham J, Forsayeth J, Eberling J, Bankiewicz KS
• Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeys.
  Experimental neurology 2005 Bankiewicz KS, Daadi M, Pivirotto P, Bringas J, Sanftner L, Cunningham J, Forsayeth JR, Eberling JL
• Real-time visualization and characterization of liposomal delivery into the monkey brain by magnetic resonance imaging.
  Brain research. Brain research protocols 2005 Krauze MT, Mcknight TR, Yamashita Y, Bringas J, Noble CO, Saito R, Geletneky K, Forsayeth J, Berger MS, Jackson P, Park JW, Bankiewicz KS
• Dimerizer regulation of AADC expression and behavioral response in AAV-transduced 6-OHDA lesioned rats.
  Molecular therapy : the journal of the American Society of Gene Therapy 2005 Sanftner LM, Rivera VM, Suzuki BM, Feng L, Berk L, Zhou S, Forsayeth JR, Clackson T, Cunningham J
• Systemic administration of propentofylline does not attenuate morphine tolerance in non-injured rodents.
  Neuroscience letters 2005 Shumilla JA, Samuels I, Johnson KW, Forsayeth JR
• Effects of the perivascular space on convection-enhanced delivery of liposomes in primate putamen.
  Experimental neurology 2005 Krauze MT, Saito R, Noble C, Bringas J, Forsayeth J, McKnight TR, Park J, Bankiewicz KS
• AAV2-mediated gene delivery to monkey putamen: evaluation of an infusion device and delivery parameters.
  Experimental neurology 2005 Sanftner LM, Sommer JM, Suzuki BM, Smith PH, Vijay S, Vargas JA, Forsayeth JR, Cunningham J, Bankiewicz KS, Kao H, Bernal J, Pierce GF, Johnson KW
• Adeno-associated virus-mediated gene transfer of human aromatic L-amino acid decarboxylase protects mixed striatal primary cultures from L-DOPA toxicity.
  Journal of neurochemistry 2005 Doroudchi MM, Liauw J, Heaton K, Zhen Z, Forsayeth JR
• Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10.
  The European journal of neuroscience 2005 Milligan ED, Langer SJ, Sloane EM, He L, Wieseler-Frank J, O'Connor K, Martin D, Forsayeth JR, Maier SF, Johnson K, Chavez RA, Leinwand LA, Watkins LR
• Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10.
  Molecular pain 2005 Milligan ED, Sloane EM, Langer SJ, Cruz PE, Chacur M, Spataro L, Wieseler-Frank J, Hammack SE, Maier SF, Flotte TR, Forsayeth JR, Leinwand LA, Chavez R, Watkins LR
• Striatal delivery of rAAV-hAADC to rats with preexisting immunity to AAV.
  Molecular therapy : the journal of the American Society of Gene Therapy 2004 Sanftner LM, Suzuki BM, Doroudchi MM, Feng L, McClelland A, Forsayeth JR, Cunningham J
• Acetylcholine receptors are required for agrin-induced clustering of postsynaptic proteins.
  The EMBO journal 2001 Marangi PA, Forsayeth JR, Mittaud P, Erb-Vögtli S, Blake DJ, Moransard M, Sander A, Fuhrer C
• Pharmacological differences between immunoisolated native brain and heterologously expressed rat alpha4beta2 nicotinic receptors.
  Brain research. Molecular brain research 2001 Truong A, Xing X, Forsayeth JR, Dwoskin LP, Crooks PA, Cohen BN
• UNCL, the mammalian homologue of UNC-50, is an inner nuclear membrane RNA-binding protein.
  Brain research 2000 Fitzgerald J, Kennedy D, Viseshakul N, Cohen BN, Mattick J, Bateman JF, Forsayeth JR
• Volatile anesthetics activate the human tandem pore domain baseline K+ channel KCNK5.
  Anesthesiology 2000 Gray AT, Zhao BB, Kindler CH, Winegar BD, Mazurek MJ, Xu J, Chavez RA, Forsayeth JR, Yost CS
• Multistep expression and assembly of neuronal nicotinic receptors is both host-cell- and receptor-subtype-dependent.
  Brain research. Molecular brain research 2000 Sweileh W, Wenberg K, Xu J, Forsayeth J, Hardy S, Loring RH
• Pharmacological similarities between native brain and heterologously expressed alpha4beta2 nicotinic receptors.
  British journal of pharmacology 1999 Shafaee N, Houng M, Truong A, Viseshakul N, Figl A, Sandhu S, Forsayeth JR, Dwoskin LP, Crooks PA, Cohen BN
• Adenovirus-mediated overexpression of c-Jun and c-Fos induces intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 in human endothelial cells.
  Arteriosclerosis, thrombosis, and vascular biology 1999 Wang N, Verna L, Hardy S, Forsayeth J, Zhu Y, Stemerman MB
• TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family.
  The Journal of biological chemistry 1999 Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS
• Two mutations linked to nocturnal frontal lobe epilepsy cause use-dependent potentiation of the nicotinic ACh response.
  The Journal of physiology 1998 Figl A, Viseshakul N, Shafaee N, Forsayeth J, Cohen BN
• TOK1 is a volatile anesthetic stimulated K+ channel.
  Anesthesiology 1998 Gray AT, Winegar BD, Leonoudakis DJ, Forsayeth JR, Yost CS
• An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 Leonoudakis D, Gray AT, Winegar BD, Kindler CH, Harada M, Taylor DM, Chavez RA, Forsayeth JR, Yost CS
• Functional deactivation of the major neuronal nicotinic receptor caused by nicotine and a protein kinase C-dependent mechanism.
  Molecular pharmacology 1997 Eilers H, Schaeffer E, Bickler PE, Forsayeth JR
• Detection of mycoplasma infection of mammalian cells.
  BioTechniques 1997 Xia H, Fitzgerald J, Bredt DS, Forsayeth JR
• Formation of oligomers containing the beta3 and beta4 subunits of the rat nicotinic receptor.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1997 Forsayeth JR, Kobrin E
• A recombinant adenovirus that directs secretion of biologically active kappa-bungarotoxin from mammalian cells.
  Brain research. Molecular brain research 1997 Gorman S, Viseshakul N, Cohen B, Hardy S, Grant GA, Yost CS, Forsayeth JR
• Volatile general anesthetics produce hyperpolarization of Aplysia neurons by activation of a discrete population of baseline potassium channels.
  Anesthesiology 1996 Winegar BD, Owen DF, Yost CS, Forsayeth JR, Mayeri E
• Intraluminal water increases expression of plasmid DNA in rat lung.
  Human gene therapy 1996 Sawa T, Miyazaki H, Pittet JF, Widdicombe JH, Gropper MA, Hashimoto S, Conrad DJ, Folkesson HG, Debs R, Forsayeth JR, Fox B, Wiener-Kronish JP
• Adenovirus-mediated transfection of cultured cells.
  BioTechniques 1994 Forsayeth JR, Garcia PD
• BiP forms stable complexes with unassembled subunits of the acetylcholine receptor in transfected COS cells and in C2 muscle cells.
  The Journal of cell biology 1992 Forsayeth JR, Gu Y, Hall ZW
• Assembly of the mammalian muscle acetylcholine receptor in transfected COS cells.
  The Journal of cell biology 1991 Gu Y, Forsayeth JR, Verrall S, Yu XM, Hall ZW
• Expression of functional mouse muscle acetylcholine receptors in Chinese hamster ovary cells.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1990 Forsayeth JR, Franco A, Rossi AB, Lansman JB, Hall ZW
• Properties of embryonic and adult muscle acetylcholine receptors transiently expressed in COS cells.
  Neuron 1990 Gu Y, Franco A, Gardner PD, Lansman JB, Forsayeth JR, Hall ZW
• Clusters of 43-kDa protein are absent from genetic variants of C2 muscle cells with reduced acetylcholine receptor expression.
  Developmental biology 1989 LaRochelle WJ, Ralston E, Forsayeth JR, Froehner SC, Hall ZW
• Reversal of insulin-induced negative cooperativity by monoclonal antibodies that stabilize the slowly dissociating ("Ksuper") state of the insulin receptor.
  Biochemical and biophysical research communications 1988 Gu JL, Goldfine ID, Forsayeth JR, De Meyts P
• Monoclonal antibodies to the human insulin receptor that activate glucose transport but not insulin receptor kinase activity.
  Proceedings of the National Academy of Sciences of the United States of America 1987 Forsayeth JR, Caro JF, Sinha MK, Maddux BA, Goldfine ID
• Effect of monoclonal antibodies on human insulin receptor autophosphorylation, negative cooperativity, and down-regulation.
  The Journal of biological chemistry 1987 Forsayeth JR, Montemurro A, Maddux BA, DePirro R, Goldfine ID
• Biosynthesis and processing of the human insulin receptor.
  Diabetes 1986 Forsayeth J, Maddux B, Goldfine ID
• Inhibition of insulin-stimulated xylose uptake in rat soleus muscle by cycloheximide.
  Diabetologia 1983 Forsayeth JR, Gould MK
• Stimulatory and inhibitory effects of hydrogen peroxide, diamide and vitamin K-5 on sugar transport in rat soleus muscle.
  Biochimica et biophysica acta 1983 Forsayeth J, Gould MK
• Inhibition of insulin-stimulated xylose uptake in denervated rat soleus muscle: a post-receptor effect.
  Diabetologia 1982 Forsayeth JR, Gould MK
• Effects of hyperosmolarity on basal and insulin-stimulated muscle sugar transport.
  The American journal of physiology 1981 Forsayeth J, Gould MK