John Feiner, MD
Professor
Anesthesia
School of Medicine

My research involvement has included multiple different projects:

• Accuracy of pulse oximetry, including determination of methemoglobin, carboxyhemoglobin, and the accuracy of cerebral oximetry.
• Organ transplantation and efforts to improve the quality of cadaveric organs.
• Acute normovolemic hemodilution to study the tolerance of acute anemia, as a way to examine red cell transfusion thresholds. Additionally, we have used this model to study other issues in transfusion, including TRALI.
• The utility of somatosensory and motor evoked potential, which are used in major spine surgery to assess the integrity of spinal cord function.
• The physiology of breathholding and drug-induced apnea.
• High altitude physiology
• Clinical effects of neuromuscular blockade

• Pulse Oximeter Performance, Racial Inequity, and the Work Ahead.
  Respiratory care 2021 Okunlola OE, Lipnick MS, Batchelder PB, Bernstein M, Feiner JR, Bickler PE
• Perioperative Normal Saline Administration and Delayed Graft Function in Patients Undergoing Kidney Transplantation: A Retrospective Cohort Study.
  Anesthesiology 2021 Kolodzie K, Cakmakkaya OS, Boparai ES, Tavakol M, Feiner JR, Kim MO, Newman TB, Niemann CU
• Anesthesia for Maternal-Fetal Interventions: A Survey of Fetal Therapy Centers in the North American Fetal Therapy Network.
  Fetal diagnosis and therapy 2021 Wood CL, Zuk J, Rollins MD, Silveira LJ, Feiner JR, Zaretsky M, Chatterjee D
• Pediatric Distraction on Induction of Anesthesia With Virtual Reality and Perioperative Anxiolysis: A Randomized Controlled Trial.
  Anesthesia and analgesia 2021 Jung MJ, Libaw JS, Ma K, Whitlock EL, Feiner JR, Sinskey JL
• "Silent" Presentation of Hypoxemia and Cardiorespiratory Compensation in COVID-19.
  Anesthesiology 2021 Bickler PE, Feiner JR, Lipnick MS, McKleroy W
• The Association Between Vena Cava Implantation Technique and Acute Kidney Injury After Liver Transplantation.
  Transplantation 2020 Hannon V, Kothari RP, Zhang L, Bokoch MP, Hill R, Roll GR, Mello A, Feiner JR, Liu KD, Niemann CU, Adelmann D
• New Method of Destroying Waste Anesthetic Gases Using Gas-Phase Photochemistry.
  Anesthesia and analgesia 2020 Rauchenwald V, Rollins MD, Ryan SM, Voronov A, Feiner JR, Šarka K, Johnson MS
• A Comparison of Spinal Anesthesia Versus Monitored Anesthesia Care With Local Anesthesia in Minimally Invasive Fetal Surgery.
  Anesthesia and analgesia 2020 Ferschl MB, Feiner J, Vu L, Smith D, Rollins MD
• Response to Burtscher re: "Increased Cytokines at High Altitude: Lack of Effect of Ibuprofen on Acute Mountain Sickness, Physiological Variables, or Cytokine Levels".
  High altitude medicine & biology 2018 Bickler P, Feiner JR, Lundeberg J
• The reliability of motor evoked potentials to predict dorsiflexion injuries during lumbosacral deformity surgery: importance of multiple myotomal monitoring.
  The spine journal : official journal of the North American Spine Society 2018 Lieberman JA, Lyon R, Jasiukaitis P, Berven SH, Burch S, Feiner J
• Increased Cytokines at High Altitude: Lack of Effect of Ibuprofen on Acute Mountain Sickness, Physiological Variables, or Cytokine Levels.
  High altitude medicine & biology 2018 Lundeberg J, Feiner JR, Schober A, Sall JW, Eilers H, Bickler PE
• Correction to: Changes in transcranial motor evoked potentials during hemorrhage are associated with increased serum propofol concentrations.
  Journal of clinical monitoring and computing 2018 Lieberman JA, Feiner J, Rollins M, Lyon R, Jasiukaitis P
• Intraoperative Management of Liver Transplant Patients Without the Routine Use of Renal Replacement Therapy.
  Transplantation 2018 Adelmann D, Olmos A, Liu LL, Feiner JR, Roll GR, Burdine L, Tavakol M, Syed S, Orandi BJ, Niemann CU
• Central venous pressure monitoring in living donor kidney recipients does not affect immediate graft function: A propensity score analysis.
  Clinical transplantation 2018 Adelmann D, Bicknell L, Niemann CU, Feiner J, Roll GR, Burdine L, Whitlock EL
• Four Types of Pulse Oximeters Accurately Detect Hypoxia during Low Perfusion and Motion.
  Anesthesiology 2018 Louie A, Feiner JR, Bickler PE, Rhodes L, Bernstein M, Lucero J
• Comparison of Transcranial Doppler and Ultrasound-Tagged Near Infrared Spectroscopy for Measuring Relative Changes in Cerebral Blood Flow in Human Subjects.
  Anesthesia and analgesia 2018 Lipnick MS, Cahill EA, Feiner JR, Bickler PE
• Effects of Changes in Arterial Carbon Dioxide and Oxygen Partial Pressures on Cerebral Oximeter Performance.
  Anesthesiology 2018 Schober A, Feiner JR, Bickler PE, Rollins MD
• Changes in transcranial motor evoked potentials during hemorrhage are associated with increased serum propofol concentrations.
  Journal of clinical monitoring and computing 2017 Lieberman JA, Feiner J, Rollins M, Lyon R, Jasiukaitis P
• Incidence and Management of Umbilical Artery Flow Abnormalities during Open Fetal Surgery.
  Fetal diagnosis and therapy 2017 Sinskey JL, Rollins MD, Whitlock E, Moon-Grady AJ, Vu L, Feiner JR, Ferschl MB
• Effects of Acute, Profound Hypoxia on Healthy Humans: Implications for Safety of Tests Evaluating Pulse Oximetry or Tissue Oximetry Performance.
  Anesthesia and analgesia 2017 Bickler PE, Feiner JR, Lipnick MS, Batchelder P, MacLeod DB, Severinghaus JW
• Evaluating Pulmonary Function: An Assessment of PaO2/FIO2.
  Critical care medicine 2017 Feiner JR, Weiskopf RB
• Tissue Oximetry and Clinical Outcomes.
  Anesthesia and analgesia 2017 Bickler P, Feiner J, Rollins M, Meng L
• The Accuracy of 6 Inexpensive Pulse Oximeters Not Cleared by the Food and Drug Administration: The Possible Global Public Health Implications.
  Anesthesia and analgesia 2016 Lipnick MS, Feiner JR, Au P, Bernstein M, Bickler PE
• In Reply.
  Anesthesiology 2016 Whitlock EL, Feiner JR, Chen LL
• The Accuracy of Pulse Spectroscopy for Detecting Hypoxemia and Coexisting Methemoglobin or Carboxyhemoglobin.
  Anesthesia and analgesia 2016 Kulcke A, Feiner J, Menn I, Holmer A, Hayoz J, Bickler P
• Predicting mortality in the intensive care unit: a comparison of the University Health Consortium expected probability of mortality and the Mortality Prediction Model III.
  Journal of intensive care 2016 Lipshutz AK, Feiner JR, Grimes B, Gropper MA
• Impact of a quality improvement project on deceased organ donor management.
  Progress in transplantation (Aliso Viejo, Calif.) 2015 Olmos A, Feiner J, Hirose R, Swain S, Blasi A, Roberts JP, Niemann CU
• Perioperative Mortality, 2010 to 2014: A Retrospective Cohort Study Using the National Anesthesia Clinical Outcomes Registry.
  Anesthesiology 2015 Whitlock EL, Feiner JR, Chen LL
• Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function.
  The New England journal of medicine 2015 Niemann CU, Feiner J, Swain S, Bunting S, Friedman M, Crutchfield M, Broglio K, Hirose R, Roberts JP, Malinoski D
• Alfentanil during rapid sequence induction with thiopental 4 mg/kg and rocuronium 0.6 mg/kg: tracheal intubation conditions.
  Acta anaesthesiologica Scandinavica 2015 Abou-Arab MH, Feiner JR, Spigset O, Heier T
• A Clinical Trial to Detect Subclinical Transfusion-induced Lung Injury during Surgery.
  Anesthesiology 2015 Feiner JR, Gropper MA, Toy P, Lieberman J, Twiford J, Weiskopf RB
• Pupillary effects of high-dose opioid quantified with infrared pupillometry.
  Anesthesiology 2014 Rollins MD, Feiner JR, Lee JM, Shah S, Larson M
• Effect of hemorrhage and hypotension on transcranial motor-evoked potentials in swine.
  Anesthesiology 2013 Lieberman JA, Feiner J, Lyon R, Rollins MD
• Factors affecting the performance of 5 cerebral oximeters during hypoxia in healthy volunteers.
  Anesthesia and analgesia 2013 Bickler PE, Feiner JR, Rollins MD
• Accuracy of the Lifebox pulse oximeter during hypoxia in healthy volunteers.
  Anaesthesia 2013 Dubowitz G, Breyer K, Lipnick M, Sall JW, Feiner J, Ikeda K, MacLeod DB, Bickler PE
• Reversal of experimental paralysis in a human by intranasal neostigmine aerosol suggests a novel approach to the early treatment of neurotoxic envenomation.
  Clinical case reports 2013 Lewin MR, Bickler P, Heier T, Feiner J, Montauk L, Mensh B
• Accuracy of carboxyhemoglobin detection by pulse CO-oximetry during hypoxemia.
  Anesthesia and analgesia 2013 Feiner JR, Rollins MD, Sall JW, Eilers H, Au P, Bickler PE
• The effect of deep and awake tracheal extubation on turnover times and postoperative respiratory complications post adenoid-tonsillectomy.
  Canadian journal of anaesthesia = Journal canadien d'anesthesie 2012 Menda SK, Gregory GA, Feiner JR, Zwass MS, Ferschl MB
• Hemoglobin desaturation after propofol/remifentanil-induced apnea: a study of the recovery of spontaneous ventilation in healthy volunteers.
  Anesthesia and analgesia 2012 Stefanutto TB, Feiner J, Krombach J, Brown R, Caldwell JE
• Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans.
  Anesthesia and analgesia 2012 Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA
• Sex-related differences in the relationship between acceleromyographic adductor pollicis train-of-four ratio and clinical manifestations of residual neuromuscular block: a study in healthy volunteers during near steady-state infusion of mivacurium.
  British journal of anaesthesia 2011 Heier T, Feiner JR, Wright PM, Ward T, Caldwell JE
• High oxygen partial pressure decreases anemia-induced heart rate increase equivalent to transfusion.
  Anesthesiology 2011 Feiner JR, Finlay-Morreale HE, Toy P, Lieberman JA, Viele MK, Hopf HW, Weiskopf RB
• Quantitative tissue oxygen measurement in multiple organs using 19F MRI in a rat model.
  Magnetic resonance in medicine 2011 Liu S, Shah SJ, Wilmes LJ, Feiner J, Kodibagkar VD, Wendland MF, Mason RP, Hylton N, Hopf HW, Rollins MD
• Donor pre-treatment with everolimus or cyclosporine does not reduce ischaemia-reperfusion injury in a rat kidney transplant model.
  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2010 Martinez-Palli G, Hirose R, Liu T, Xu F, Dang K, Feiner J, Serkova NJ, Niemann CU
• Relationship between normalized adductor pollicis train-of-four ratio and manifestations of residual neuromuscular block: a study using acceleromyography during near steady-state concentrations of mivacurium.
  Anesthesiology 2010 Heier T, Caldwell JE, Feiner JR, Liu L, Ward T, Wright PM
• Improved accuracy of methemoglobin detection by pulse CO-oximetry during hypoxia.
  Anesthesia and analgesia 2010 Feiner JR, Bickler PE
• Emergent orthotopic liver transplantation for hemorrhage from a giant cavernous hepatic hemangioma: case report and review.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2010 Vagefi PA, Klein I, Gelb B, Hameed B, Moff SL, Simko JP, Fix OK, Eilers H, Feiner JR, Ascher NL, Freise CE, Bass NM
• Quality improvement in transplant anesthesia: which way forward?
  Current opinion in organ transplantation 2010 Niemann CU, Feiner J
• Accuracy of methemoglobin detection by pulse CO-oximetry during hypoxia.
  Anesthesia and analgesia 2009 Feiner JR, Bickler PE, Mannheimer PD
• Acute kidney injury during liver transplantation as determined by neutrophil gelatinase-associated lipocalin.
  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2009 Niemann CU, Walia A, Waldman J, Davio M, Roberts JP, Hirose R, Feiner J
• Relative efficacy of transcranial motor evoked potentials, mechanically-elicited electromyography, and evoked EMG to assess nerve root function during sustained retraction in a porcine model.
  Spine 2009 Lyon R, Lieberman JA, Feiner J, Burch S
• Predictors associated with terminal renal function in deceased organ donors in the intensive care unit.
  Anesthesiology 2009 Blasi-Ibanez A, Hirose R, Feiner J, Freise C, Stock PG, Roberts JP, Niemann CU
• Red blood cell age and function.
  Transfusion 2008 Weiskopf RB, Feiner J, Toy P
• The efficacy of motor evoked potentials in fixed sagittal imbalance deformity correction surgery.
  Spine 2008 Lieberman JA, Lyon R, Feiner J, Hu SS, Berven SH
• Dark skin decreases the accuracy of pulse oximeters at low oxygen saturation: the effects of oximeter probe type and gender.
  Anesthesia and analgesia 2007 Feiner JR, Severinghaus JW, Bickler PE
• Visual loss after spinal surgery.
  Anesthesiology 2007 Weiskopf RB, Feiner J, Lieberman J, Hu SS
• Central venous pressure monitoring during living right donor hepatectomy.
  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2007 Niemann CU, Feiner J, Behrends M, Eilers H, Ascher NL, Roberts JP
• The effect of age on motor evoked potentials in children under propofol/isoflurane anesthesia.
  Anesthesia and analgesia 2006 Lieberman JA, Lyon R, Feiner J, Diab M, Gregory GA
• Fresh blood and aged stored blood are equally efficacious in immediately reversing anemia-induced brain oxygenation deficits in humans.
  Anesthesiology 2006 Weiskopf RB, Feiner J, Hopf H, Lieberman J, Finlay HE, Quah C, Kramer JH, Bostrom A, Toy P
• Designing and testing a computer-based screening system for transfusion-related acute lung injury.
  American journal of clinical pathology 2005 Finlay HE, Cassorla L, Feiner J, Toy P
• Effects of skin pigmentation on pulse oximeter accuracy at low saturation.
  Anesthesiology 2005 Bickler PE, Feiner JR, Severinghaus JW
• Acute isovolemic anemia impairs central processing as determined by P300 latency.
  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2005 Weiskopf RB, Toy P, Hopf HW, Feiner J, Finlay HE, Takahashi M, Bostrom A, Songster C, Aminoff MJ
• Mild hypothermia, but not propofol, is neuroprotective in organotypic hippocampal cultures.
  Anesthesia and analgesia 2005 Feiner JR, Bickler PE, Estrada S, Donohoe PH, Fahlman CS, Schuyler JA
• Progressive suppression of motor evoked potentials during general anesthesia: the phenomenon of "anesthetic fade".
  Journal of neurosurgical anesthesiology 2005 Lyon R, Feiner J, Lieberman JA
• No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects.
  Clinical pharmacology and therapeutics 2003 Pauli-Magnus C, Feiner J, Brett C, Lin E, Kroetz DL
• Acute isovolemic anemia does not impair peripheral or central nerve conduction.
  Anesthesiology 2003 Weiskopf RB, Aminoff MJ, Hopf HW, Feiner J, Viele MK, Watson JJ, Ho R, Songster C, Toy P
• Heart rate increases linearly in response to acute isovolemic anemia.
  Transfusion 2003 Weiskopf RB, Feiner J, Hopf H, Viele MK, Watson JJ, Lieberman J, Kelley S, Toy P
• Oxygen reverses deficits of cognitive function and memory and increased heart rate induced by acute severe isovolemic anemia.
  Anesthesiology 2002 Weiskopf RB, Feiner J, Hopf HW, Viele MK, Watson JJ, Kramer JH, Ho R, Toy P
• Subcutaneous perfusion and oxygen during acute severe isovolemic hemodilution in healthy volunteers.
  Archives of surgery (Chicago, Ill. : 1960) 2000 Hopf HW, Viele M, Watson JJ, Feiner J, Weiskopf R, Hunt TK, Noorani M, Yeap H, Ho R, Toy P
• Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans.
  Anesthesiology 2000 Leung JM, Weiskopf RB, Feiner J, Hopf HW, Kelley S, Viele M, Lieberman J, Watson J, Noorani M, Pastor D, Yeap H, Ho R, Toy P
• Acute severe isovolemic anemia impairs cognitive function and memory in humans.
  Anesthesiology 2000 Weiskopf RB, Kramer JH, Viele M, Neumann M, Feiner JR, Watson JJ, Hopf HW, Toy P
• Fatigue during acute isovolemic anemiain healthy, resting humans.
  Transfusion 2000 Toy P, Feiner J, Viele MK, Watson J, Yeap H, Weiskopf RB
• Critical oxygen delivery in conscious humans is less than 7.3 ml O2 x kg(-1) x min(-1).
  Anesthesiology 2000 Lieberman JA, Weiskopf RB, Kelley SD, Feiner J, Noorani M, Leung J, Toy P, Viele M
• Tidal volume, PaCO2, and lung injury.
  Critical care medicine 1998 Gregory GA, Feiner J, Severinghaus JW
• Human cardiovascular and metabolic response to acute, severe isovolemic anemia.
  JAMA 1998 Weiskopf RB, Viele MK, Feiner J, Kelley S, Lieberman J, Noorani M, Leung JM, Fisher DM, Murray WR, Toy P, Moore MA
• Interactive effects of pH and temperature on N-methyl-D-aspartate receptor activity in rat cortical brain slices.
  Journal of neurosurgical anesthesiology 1997 Gray AT, Buck LT, Feiner JR, Bickler PE
• Exercise-induced VA/Q inequality in subjects with prior high-altitude pulmonary edema.
  Journal of applied physiology (Bethesda, Md. : 1985) 1996 Podolsky A, Eldridge MW, Richardson RS, Knight DR, Johnson EC, Hopkins SR, Johnson DH, Michimata H, Grassi B, Feiner J, Kurdak SS, Bickler PE, Severinghaus JW, Wagner PD
• Pulmonary hemodynamic response to exercise in subjects with prior high-altitude pulmonary edema.
  Journal of applied physiology (Bethesda, Md. : 1985) 1996 Eldridge MW, Podolsky A, Richardson RS, Johnson DH, Knight DR, Johnson EC, Hopkins SR, Michimata H, Grassi B, Feiner J, Kurdak SS, Bickler PE, Wagner PD, Severinghaus JW
• Volatile and intravenous anesthetics decrease glutamate release from cortical brain slices during anoxia.
  Anesthesiology 1995 Bickler PE, Buck LT, Feiner JR
• Hypoxic ventilatory response predicts the extent of maximal breath-holds in man.
  Respiration physiology 1995 Feiner JR, Bickler PE, Severinghaus JW
• Hemodynamic effects of intermittent pneumatic compression of the legs.
  Anesthesiology 1987 Unger RJ, Feiner JR