John Fahy, MD
Professor
Medicine
School of Medicine
I am a Professor of Medicine in the Division of Pulmonary and Critical Care Medicine and the Department of Medicine at UCSF. I direct a research program in asthma and other airway diseases that is human centered and focused on uncovering disease mechanisms and improving treatment.
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MAJOR GOALS: (i) To define abnormalities in airway epithelial cell function that contribute to abnormal type 2 immune responses in asthma; (ii) To explore mechanisms of formation of pathologic mucus gels in the airway so that novel mucolytics can be developed; (iii) To explore the heterogeneity of molecular mechanisms in asthma to improve prospects for treatment approaches that are patient specific.
(i) ABNORMAL TYPE 2 IMMUNE RESPONSES IN HUMAN ASTHMA: The airway epithelium has emerged as an important regulator of innate and adaptive immune responses that result in type 2 allergic airway inflammation. My lab is specifically investigating epithelial mechanisms that contribute to upregulation of Th2 cytokines in the asthmatic airway. Our experimental approaches include gene and protein expression analysis of airway epithelial brushings, biopsies, and secretions, and cell culture studies in airway epithelial cells from human donors. We collaborate with multiple other UCSF labs, including the Locksley, Ansel, and Woodruff labs.
(ii) PATHOLOGIC MUCUS GELS: The formation of pathologic mucus is a feature of multiple lung diseases and has multiple consequences for lung health, including airflow obstruction and infections. My lab is investigating how pathologic mucus gels form. Our experimental approaches include detailed analyses of sputum samples using rheology-, imaging- and biochemistry-based approaches. We use the data from analysis of pathologic mucus to inform strategies for development of novel mucolytics. Important collaborators include Drs Stefan Oscarson and Stephen Carrington at University College Dublin.
(iii) HETEROGENEITY OF MOLECULAR MECHANISMS IN ASTHMA: Many asthmatics do not respond well to currently available treatments and one reason is that current medications assume a one size fits all approach. My lab is applying a variety of targeted and unbiased approaches to investigate disease mechanism in large numbers of asthmatics with a view to improving understanding of the range and frequency of disease mechanisms that underlie asthma. Our experimental approaches include detailed analysis of the differential expression of genes and proteins in airway biospecimens collected from highly characterized patients with asthma and healthy controls. We also simultaneously explore how simpler tests in blood might reveal specific disease mechanisms and serve as biomarkers for personalizing treatment. Our work in this area is done in collaboration with the Woodruff lab at UCSF and with investigators in the NIH Severe Asthma Research Program (SARP).
Education & Training
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- Residency School of Medicine University of California, San Francisco
Websites
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- Clinical Profile at UCSF Medical Center (ucsfhealth.org)
- Fahy Lab at UCSF (cvri.ucsf.edu)
- UCSF Airway Clinical Research Center (acrc.ucsf.edu)
Grants and Projects
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- Exploring the biology of persistent type 2 airway niches in asthma, NIH, 2012-2024
- Exploring the biology of persistent type 2 airway niches in asthma, NIH, 2012-2024
- Sequential, Multiple Assignment, Randomized Trial in Severe Asthma Protocol (SMART-SA), NIH, 2017-2023
- Carbohydrate-based Therapy for Lung Disease, NIH, 2016-2021
- Mechanism of mucus pathology in asthma exacerbations, NIH, 2005-2021
- Clinical and Molecular Phenotypes of Severe Asthma, NIH, 2011-2019
- Preventing fucose-dependent binding of aspergillus and pseudomonas to lung mucin, NIH, 2011-2015
- General Clinical Research Center, NIH, 1974-2009
- T Cell Inflammation and Mucin Hypersecretion in Copd, NIH, 2001-2005
- Goblet Cell Dysfunction in Asthma, NIH, 1998-2003
Publications (233)
Top publication keywords:
SputumMucinsLectinsLungBronchiMucusAsthmaAdrenal Cortex HormonesImmunoglobulin ERespiratory MucosaEosinophilsMast CellsMucin-5BTh2 CellsAnti-Asthmatic Agents
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Persistent mucus plugs in proximal airways are consequential for airflow limitation in asthma.
JCI insight 2024 Huang BK, Elicker BM, Henry TS, Kallianos KG, Hahn LD, Tang M, Heng F, McCulloch CE, Bhakta NR, Majumdar S, Choi J, Denlinger LC, Fain SB, Hastie AT, Hoffman EA, Israel E, Jarjour NN, Levy BD, Mauger … -
A Novel Air Trapping Segment Score Identifies Opposing Effects of Obesity and Eosinophilia on Air Trapping in Asthma.
American journal of respiratory and critical care medicine 2023 Leung C, Tang M, Huang BK, Fain SB, Hoffman EA, Choi J, Dunican EM, Mauger DT, Denlinger LC, Jarjour NN, Israel E, Levy BD, Wenzel SE, Sumino K, Hastie AT, Schirm J, McCulloch CE, Peters MC, Woodruff … -
A novel thiol-saccharide mucolytic for the treatment of muco-obstructive lung diseases.
The European respiratory journal 2023 Addante A, Raymond W, Gitlin I, Charbit A, Orain X, Scheffler AW, Kuppe A, Duerr J, Daniltchenko M, Drescher M, Graeber SY, Healy AM, Oscarson S, Fahy JV, Mall MA -
Genetic analyses of chr11p15.5 region identify MUC5AC-MUC5B associated with asthma-related phenotypes.
The Journal of asthma : official journal of the Association for the Care of Asthma 2023 Li X, Li H, Christenson SA, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston BM, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff PG, Bleecker ER, Meyers … -
Investigations of a combination of atopic status and age of asthma onset identify asthma subphenotypes.
The Journal of asthma : official journal of the Association for the Care of Asthma 2023 Li H, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Wenzel SE, Zein J, Bleecker ER, Meyers DA, Chen Y, Li X, NHLBI Severe Asthma Research …
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CCL5 is a potential bridge between type 1 and type 2 inflammation in asthma.
The Journal of allergy and clinical immunology 2023 Gauthier M, Kale SL, Oriss TB, Gorry M, Ramonell RP, Dalton K, Ray P, Fahy JV, Seibold MA, Castro M, Jarjour N, Gaston B, Bleecker ER, Meyers DA, Moore W, Hastie AT, Israel E, Levy BD, Mauger D, … -
Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity.
American journal of respiratory and critical care medicine 2023 Li X, Guerra S, Ledford JG, Kraft M, Li H, Hastie AT, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff… -
Skeletal Muscle Adiposity and Lung Function Trajectory in the Severe Asthma Research Program.
American journal of respiratory and critical care medicine 2023 Tattersall MC, Lee KE, Tsuchiya N, Osman F, Korcarz CE, Hansen KM, Peters MC, Fahy JV, Longhurst CA, Dunican E, Wentzel SE, Leader JK, Israel E, Levy BD, Castro M, Erzurum SC, Lempel J, Moore WC, … -
Reply to Nie et al. and Bhammar et al.
American journal of respiratory and critical care medicine 2023 Peters MC, Schiebler ML, Mauger DT, Fahy JV -
Reply to Ikeda and Tomita.
American journal of respiratory and critical care medicine 2022 Tang M, Mauger DT, Fahy JV, Dunican EM -
The Impact of Insulin Resistance on Loss of Lung Function and Response to Treatment in Asthma.
American journal of respiratory and critical care medicine 2022 Peters MC, Schiebler ML, Cardet JC, Johansson MW, Sorkness R, DeBoer MD, Bleecker ER, Meyers DA, Castro M, Sumino K, Erzurum SC, Tattersall MC, Zein JG, Hastie AT, Moore W, Levy BD, Israel E, Phillips… -
Urinary total conjugated 3-bromotyrosine, asthma severity, and exacerbation risk.
American journal of physiology. Lung cellular and molecular physiology 2022 Wang Z, Xu W, Comhair SAA, Fu X, Shao Z, Bearden R, Zein JG, Bleecker ER, Castro M, Denlinger LC, Fahy JV, Israel E, Levy BD, Jarjour NN, Moore WC, Wenzel SE, Mauger DT, Gaston B, Hazen SL, Erzurum SC -
Exploring antiviral and anti-inflammatory effects of thiol drugs in COVID-19.
American journal of physiology. Lung cellular and molecular physiology 2022 Khanna K, Raymond WW, Jin J, Charbit AR, Gitlin I, Tang M, Werts AD, Barrett EG, Cox JM, Birch SM, Martinelli R, Sperber HS, Franz S, Duff T, Hoffmann M, Healy AM, Oscarson S, Pöhlmann S, Pillai SK, … -
DNA sequencing analysis of cystic fibrosis transmembrane conductance regulator gene identifies cystic fibrosis-associated variants in the Severe Asthma Research Program.
Pediatric pulmonology 2022 Izquierdo ME, Marion CR, Moore WC, Raraigh KS, Taylor-Cousar JL, Cutting GR, Ampleford E, Hawkins GA, Zein J, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Israel E, Jarjour NN, Mauger D, Levy BD, … -
Mucus Plugs Persist in Asthma, and Changes in Mucus Plugs Associate with Changes in Airflow over Time.
American journal of respiratory and critical care medicine 2022 Tang M, Elicker BM, Henry T, Gierada DS, Schiebler ML, Huang BK, Peters MC, Castro M, Hoffman EA, Fain SB, Ash SY, Choi J, Hall C, Phillips BR, Mauger DT, Denlinger LC, Jarjour NN, Israel E, … -
Quantitative CT Characteristics of Cluster Phenotypes in the Severe Asthma Research Program Cohorts.
Radiology 2022 Trivedi AP, Hall C, Goss CW, Lew D, Krings JG, McGregor MC, Samant M, Sieren JP, Li H, Schechtman KB, Schirm J, McEleney S, Peterson S, Moore WC, Bleecker ER, Meyers DA, Israel E, Washko GR, Levy BD, … -
The Mucin Gene MUC5B Is Required for Normal Lung Function.
American journal of respiratory and critical care medicine 2022 Liegeois MA, Fahy JV -
Obesity alters pathology and treatment response in inflammatory disease.
Nature 2022 Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ, Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, … -
Mucus secretion blocked at its source in the lungs.
Nature 2022 Gitlin I, Fahy JV -
15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation.
The Journal of clinical investigation 2022 Nagasaki T, Schuyler AJ, Zhao J, Samovich SN, Yamada K, Deng Y, Ginebaugh SP, Christenson SA, Woodruff PG, Fahy JV, Trudeau JB, Stoyanovsky D, Ray A, Tyurina YY, Kagan VE, Wenzel SE -
Mucus Plugs in Asthma at CT Associated with Regional Ventilation Defects at 3He MRI.
Radiology 2021 Mummy DG, Dunican EM, Carey KJ, Evans MD, Elicker BM, Newell JD, Gierada DS, Nagle SK, Schiebler ML, Sorkness RL, Jarjour NN, Denlinger LC, Fahy JV, Fain SB -
The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions.
The Journal of allergy and clinical immunology 2021 Georas SN, Wright RJ, Ivanova A, Israel E, LaVange LM, Akuthota P, Carr TF, Denlinger LC, Fajt ML, Kumar R, O'Neal WK, Phipatanakul W, Szefler SJ, Aronica MA, Bacharier LB, Burbank AJ, Castro M, … -
Thiol drugs decrease SARS-CoV-2 lung injury in vivo and disrupt SARS-CoV-2 spike complex binding to ACE2 in vitro.
bioRxiv : the preprint server for biology 2021 Khanna K, Raymond W, Jin J, Charbit AR, Gitlin I, Tang M, Werts AD, Barrett EG, Cox JM, Birch SM, Martinelli R, Sperber HS, Franz S, Pillai S, Healy AM, Duff T, Oscarson S, Hoffmann M, Pöhlmann S, … -
Benefits of Airway Androgen Receptor Expression in Human Asthma.
American journal of respiratory and critical care medicine 2021 Zein JG, McManus JM, Sharifi N, Erzurum SC, Marozkina N, Lahm T, Giddings O, Davis MD, DeBoer MD, Comhair SA, Bazeley P, Kim HJ, Busse W, Calhoun W, Castro M, Chung KF, Fahy JV, Israel E, Jarjour NN, … -
Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium.
Genome medicine 2021 Kasela S, Ortega VE, Martorella M, Garudadri S, Nguyen J, Ampleford E, Pasanen A, Nerella S, Buschur KL, Barjaktarevic IZ, Barr RG, Bleecker ER, Bowler RP, Comellas AP, Cooper CB, Couper DJ, Criner GJ… -
Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers.
American journal of respiratory and critical care medicine 2021 Dunican EM, Elicker BM, Henry T, Gierada DS, Schiebler ML, Anderson W, Barjaktarevic I, Barr RG, Bleecker ER, Boucher RC, Bowler R, Christenson SA, Comellas A, Cooper CB, Couper D, Criner GJ, … -
Mixed Sputum Granulocyte Longitudinal Impact on Lung Function in the Severe Asthma Research Program.
American journal of respiratory and critical care medicine 2021 Hastie AT, Mauger DT, Denlinger LC, Coverstone A, Castro M, Erzurum S, Jarjour N, Levy BD, Meyers DA, Moore WC, Phillips BR, Wenzel SE, Fahy JV, Israel E, Bleecker ER -
Responsiveness to Parenteral Corticosteroids and Lung Function Trajectory in Adults with Moderate-to-Severe Asthma.
American journal of respiratory and critical care medicine 2021 Denlinger LC, Phillips BR, Sorkness RL, Bleecker ER, Castro M, DeBoer MD, Fitzpatrick AM, Hastie AT, Gaffin JM, Moore WC, Peters MC, Peters SP, Phipatanakul W, Cardet JC, Erzurum SC, Fahy JV, Fajt ML,… -
PrecISE: Precision Medicine in Severe Asthma: An adaptive platform trial with biomarker ascertainment.
The Journal of allergy and clinical immunology 2021 Israel E, Denlinger LC, Bacharier LB, LaVange LM, Moore WC, Peters MC, Georas SN, Wright RJ, Mauger DT, Noel P, Akuthota P, Bach J, Bleecker ER, Cardet JC, Carr TF, Castro M, Cinelli A, Comhair SAA, … -
Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3.
The Journal of allergy and clinical immunology 2021 Krings JG, Goss CW, Lew D, Samant M, McGregor MC, Boomer J, Bacharier LB, Sheshadri A, Hall C, Brownell J, Schechtman KB, Peterson S, McEleney S, Mauger DT, Fahy JV, Fain SB, Denlinger LC, Israel E, … -
Erratum: COVID-19-related Genes in Sputum Cells in Asthma: Relationship to Demographic Features and Corticosteroids.
American journal of respiratory and critical care medicine 2020 Peters MC, Fahy JV -
The Use of a Three-Fluid Atomising Nozzle in the Production of Spray-Dried Theophylline/Salbutamol Sulphate Powders Intended for Pulmonary Delivery.
Pharmaceutics 2020 Focaroli S, Jiang G, O'Connell P, Fahy JV, Healy AM -
Reply to Nannini and to Lipworth et al.
American journal of respiratory and critical care medicine 2020 Peters MC, Fahy JV, Denlinger LC -
Evidence for Exacerbation-Prone Asthma and Predictive Biomarkers of Exacerbation Frequency.
American journal of respiratory and critical care medicine 2020 Peters MC, Mauger D, Ross KR, Phillips B, Gaston B, Cardet JC, Israel E, Levy BD, Phipatanakul W, Jarjour NN, Castro M, Wenzel SE, Hastie A, Moore W, Bleecker E, Fahy JV, Denlinger LC -
The precision interventions for severe and/or exacerbation-prone asthma (PrecISE) adaptive platform trial: statistical considerations.
Journal of biopharmaceutical statistics 2020 Ivanova A, Israel E, LaVange LM, Peters MC, Denlinger LC, Moore WC, Bacharier LB, Marquis MA, Gotman NM, Kosorok MR, Tomlinson C, Mauger DT, Georas SN, Wright RJ, Noel P, Rosner GL, Akuthota P, … -
Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways.
The Journal of allergy and clinical immunology 2020 Li X, Christenson SA, Modena B, Li H, Busse WW, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Hastie AT, Israel E, Jarjour NN, Levy BD, Moore WC, Woodruff PG, Kaminski N, Wenzel SE, Bleecker … -
An anti-siglec-8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2020 Kerr SC, Gonzalez JR, Schanin J, Peters MC, Lambrecht BN, Brock EC, Charbit A, Ansel KM, Youngblood BA, Fahy JV -
COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids.
American journal of respiratory and critical care medicine 2020 Peters MC, Sajuthi S, Deford P, Christenson S, Rios CL, Montgomery MT, Woodruff PG, Mauger DT, Erzurum SC, Johansson MW, Denlinger LC, Jarjour NN, Castro M, Hastie AT, Moore W, Ortega VE, Bleecker ER,… -
Baseline sputum eosinophil + neutrophil subgroups' clinical characteristics and longitudinal trajectories for NHLBI Severe Asthma Research Program (SARP 3) cohort.
The Journal of allergy and clinical immunology 2020 Hastie AT, Mauger DT, Denlinger LC, Coverstone A, Castro M, Erzurum S, Jarjour N, Levy BD, Meyers DA, Moore WC, Phillips B, Wenzel SE, Fahy JV, Israel E, Bleecker ER, NHLBI SARP 3 Investigators -
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Cell 2020 Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, Franke Y, Wu X, Zhang J, Liu J, Wu P, Chang D, … -
HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma.
Proceedings of the National Academy of Sciences of the United States of America 2020 Zein J, Gaston B, Bazeley P, DeBoer MD, Igo RP, Bleecker ER, Meyers D, Comhair S, Marozkina NV, Cotton C, Patel M, Alyamani M, Xu W, Busse WW, Calhoun WJ, Ortega V, Hawkins GA, Castro M, Chung KF, … -
Severe asthma during childhood and adolescence: A longitudinal study.
The Journal of allergy and clinical immunology 2019 Ross KR, Gupta R, DeBoer MD, Zein J, Phillips BR, Mauger DT, Li C, Myers RE, Phipatanakul W, Fitzpatrick AM, Ly NP, Bacharier LB, Jackson DJ, Celedón JC, Larkin A, Israel E, Levy B, Fahy JV, Castro M,… -
Development and initial validation of the Asthma Severity Scoring System (ASSESS).
The Journal of allergy and clinical immunology 2019 Fitzpatrick AM, Szefler SJ, Mauger DT, Phillips BR, Denlinger LC, Moore WC, Sorkness RL, Wenzel SE, Gergen PJ, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Israel E, Levy BD, Meyers DA, … -
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Cell 2019 Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, Franke Y, Wu X, Zhang J, Liu J, Wu P, Chang D, … -
The use of hydrophobic amino acids in protecting spray dried trehalose formulations against moisture-induced changes.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2019 Mah PT, O'Connell P, Focaroli S, Lundy R, O'Mahony TF, Hastedt JE, Gitlin I, Oscarson S, Fahy JV, Healy AM -
Estimated Ventricular Size, Asthma Severity, and Exacerbations: The Severe Asthma Research Program III Cohort.
Chest 2019 Ash SY, Sanchez-Ferrero GV, Schiebler ML, Rahaghi FN, Rai A, Come CE, Ross JC, Colon AG, Cardet JC, Bleecker ER, Castro M, Fahy JV, Fain SB, Gaston BM, Hoffman EA, Jarjour NN, Lempel JK, Mauger DT, … -
Investigation of the relationship between IL-6 and type 2 biomarkers in patients with severe asthma.
The Journal of allergy and clinical immunology 2019 Li X, Hastie AT, Peters MC, Hawkins GA, Phipatanakul W, Li H, Moore WC, Busse WW, Castro M, Erzurum SC, Gaston B, Israel E, Jarjour NN, Levy BD, Wenzel SE, Meyers DA, Fahy JV, Bleecker ER, National … -
Making Asthma Crystal Clear.
The New England journal of medicine 2019 Fahy JV, Locksley RM -
Clinical significance of the bronchodilator response in children with severe asthma.
Pediatric pulmonology 2019 Coverstone AM, Bacharier LB, Wilson BS, Fitzpatrick AM, Teague WG, Phipatanakul W, Wenzel SE, Gaston BM, Bleecker ER, Moore WC, Ramratnam S, Jarjour NN, Ly NP, Fahy JV, Mauger DT, Schechtman KB, Yin-… -
Multiview Cluster Analysis Identifies Variable Corticosteroid Response Phenotypes in Severe Asthma.
American journal of respiratory and critical care medicine 2019 Wu W, Bang S, Bleecker ER, Castro M, Denlinger L, Erzurum SC, Fahy JV, Fitzpatrick AM, Gaston BM, Hastie AT, Israel E, Jarjour NN, Levy BD, Mauger DT, Meyers DA, Moore WC, Peters M, Phillips BR, … -
Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level.
The New England journal of medicine 2019 Lazarus SC, Krishnan JA, King TS, Lang JE, Blake KV, Covar R, Lugogo N, Wenzel S, Chinchilli VM, Mauger DT, Dyer AM, Boushey HA, Fahy JV, Woodruff PG, Bacharier LB, Cabana MD, Cardet JC, Castro M, … -
Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma.
American journal of respiratory and critical care medicine 2019 Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, … -
The effect of BPIFA1/SPLUNC1 genetic variation on its expression and function in asthmatic airway epithelium.
JCI insight 2019 Schaefer N, Li X, Seibold MA, Jarjour NN, Denlinger LC, Castro M, Coverstone AM, Teague WG, Boomer J, Bleecker ER, Meyers DA, Moore WC, Hawkins GA, Fahy J, Phillips BR, Mauger DT, Dakhama A, Gellatly … -
The Cytokines of Asthma.
Immunity 2019 Lambrecht BN, Hammad H, Fahy JV -
A Design of Experiment (DoE) approach to optimise spray drying process conditions for the production of trehalose/leucine formulations with application in pulmonary delivery.
International journal of pharmaceutics 2019 Focaroli S, Mah PT, Hastedt JE, Gitlin I, Oscarson S, Fahy JV, Healy AM -
A Transcriptomic Method to Determine Airway Immune Dysfunction in T2-High and T2-Low Asthma.
American journal of respiratory and critical care medicine 2019 Peters MC, Ringel L, Dyjack N, Herrin R, Woodruff PG, Rios C, O'Connor B, Fahy JV, Seibold MA -
Racial disparities in asthma-related health care use in the National Heart, Lung, and Blood Institute's Severe Asthma Research Program.
The Journal of allergy and clinical immunology 2019 Fitzpatrick AM, Gillespie SE, Mauger DT, Phillips BR, Bleecker ER, Israel E, Meyers DA, Moore WC, Sorkness RL, Wenzel SE, Bacharier LB, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston BM, Jarjour … -
Autopsy and Imaging Studies of Mucus in Asthma. Lessons Learned about Disease Mechanisms and the Role of Mucus in Airflow Obstruction.
Annals of the American Thoracic Society 2018 Dunican EM, Watchorn DC, Fahy JV -
Purpose of the Conference: The 2018 Transatlantic Conference on Lung Diseases.
Annals of the American Thoracic Society 2018 MacNee W, Fahy JV, Nicod LP, Kolls J -
Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma.
Science immunology 2018 Krishnamoorthy N, Douda DN, Brüggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN… -
Pruning of the Pulmonary Vasculature in Asthma. The Severe Asthma Research Program (SARP) Cohort.
American journal of respiratory and critical care medicine 2018 Ash SY, Rahaghi FN, Come CE, Ross JC, Colon AG, Cardet-Guisasola JC, Dunican EM, Bleecker ER, Castro M, Fahy JV, Fain SB, Gaston BM, Hoffman EA, Jarjour NN, Mauger DT, Wenzel SE, Levy BD, San Jose … -
Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma.
BMC pulmonary medicine 2018 DeBoer MD, Phillips BR, Mauger DT, Zein J, Erzurum SC, Fitzpatrick AM, Gaston BM, Myers R, Ross KR, Chmiel J, Lee MJ, Fahy JV, Peters M, Ly NP, Wenzel SE, Fajt ML, Holguin F, Moore WC, Peters SP, … -
ALX receptor ligands define a biochemical endotype for severe asthma.
JCI insight 2018 Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, … -
Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids.
The Journal of allergy and clinical immunology 2018 Peters MC, Kerr S, Dunican EM, Woodruff PG, Fajt ML, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, … -
Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity.
Cell discovery 2018 Lachowicz-Scroggins ME, Gordon ED, Wesolowska-Andersen A, Jackson ND, MacLeod HJ, Sharp LZ, Sun M, Seibold MA, Fahy JV -
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
The Journal of clinical investigation 2018 Dunican EM, Elicker BM, Gierada DS, Nagle SK, Schiebler ML, Newell JD, Raymond WW, Lachowicz-Scroggins ME, Di Maio S, Hoffman EA, Castro M, Fain SB, Jarjour NN, Israel E, Levy BD, Erzurum SC, Wenzel … -
IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma.
American journal of respiratory and critical care medicine 2018 Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG -
Purpose of the Conference: The 2017 Transatlantic Conference on Lung Diseases.
Annals of the American Thoracic Society 2017 MacNee W, Fahy JV, Nicod LP, Kolls J -
Internet-Based Monitoring in the Severe Asthma Research Program Identifies a Subgroup of Patients With Labile Asthma Control.
Chest 2017 Wong-McGrath K, Denlinger LC, Bleecker ER, Castro M, Gaston B, Israel E, Jarjour NN, Mauger DT, Peters S, Phillips BR, Wenzel SE, Fahy JV, Peters MC, National Heart Lung and Blood Institute’s Severe … -
Corticosteroid and long-acting ß-agonist therapy reduces epithelial goblet cell metaplasia.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2017 Lachowicz-Scroggins ME, Finkbeiner WE, Gordon ED, Yuan S, Zlock L, Bhakta NR, Woodruff PG, Fahy JV, Boushey HA -
After asthma: redefining airways diseases.
Lancet (London, England) 2017 Pavord ID, Beasley R, Agusti A, Anderson GP, Bel E, Brusselle G, Cullinan P, Custovic A, Ducharme FM, Fahy JV, Frey U, Gibson P, Heaney LG, Holt PG, Humbert M, Lloyd CM, Marks G, Martinez FD, Sly PD, … -
Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age.
The journal of allergy and clinical immunology. In practice 2017 Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, … -
ALX receptor ligands define a biochemical endotype for severe asthma.
JCI insight 2017 Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, … -
Asthma and corticosteroids: time for a more precise approach to treatment.
The European respiratory journal 2017 Dunican EM, Fahy JV -
Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma.
American journal of respiratory and critical care medicine 2017 Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy JV, Fitzpatrick AM, Gaston BM, … -
Natural killer cell-mediated inflammation resolution is disabled in severe asthma.
Science immunology 2017 Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone … -
Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations.
American journal of respiratory and critical care medicine 2017 Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, … -
Purpose of the Conference: 2016 Transatlantic Airway Conference.
Annals of the American Thoracic Society 2016 MacNee W, Fahy JV, Nicod LP, Kolls JK -
Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma.
American journal of respiratory and critical care medicine 2016 Lachowicz-Scroggins ME, Yuan S, Kerr SC, Dunican EM, Yu M, Carrington SD, Fahy JV -
Measuring Airway Mucin 2 in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization.
Annals of the American Thoracic Society 2016 Dickey BF, Fahy JV, Kesimer M, Boucher RC, Evans CM, Thornton D -
Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III.
Chest 2016 Luyster FS, Strollo PJ, Holguin F, Castro M, Dunican EM, Fahy J, Gaston B, Israel E, Jarjour NN, Mauger DT, Moore WC, Wenzel SE -
IL1RL1 asthma risk variants regulate airway type 2 inflammation.
JCI insight 2016 Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy JV, … -
Metabolic consequences of obesity as an "outside in" mechanism of disease severity in asthma.
The European respiratory journal 2016 Peters MC, Fahy JV -
Alternative splicing of interleukin-33 and type 2 inflammation in asthma.
Proceedings of the National Academy of Sciences of the United States of America 2016 Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-Scroggins ME, Peters MC, Wesolowska-Andersen A, Gonzalez JR, MacLeod HJ, Christian LS, Yuan S, Barry L, Woodruff PG, Ansel KM, Nocka K, Seibold MA, … -
Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts.
The Lancet. Respiratory medicine 2016 Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, … -
Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25.
American journal of respiratory and critical care medicine 2016 Gordon ED, Locksley RM, Fahy JV -
Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma.
The Journal of allergy and clinical immunology 2016 Sweerus K, Lachowicz-Scroggins M, Gordon E, LaFemina M, Huang X, Parikh M, Kanegai C, Fahy JV, Frank JA -
FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection.
PLoS pathogens 2016 Kerr SC, Fischer GJ, Sinha M, McCabe O, Palmer JM, Choera T, Lim FY, Wimmerova M, Carrington SD, Yuan S, Lowell CA, Oscarson S, Keller NP, Fahy JV -
Mast cells in asthma: biomarker and therapeutic target.
The European respiratory journal 2016 Reber LL, Fahy JV -
Asthma Was Talking, But We Weren't Listening. Missed or Ignored Signals That Have Slowed Treatment Progress.
Annals of the American Thoracic Society 2016 Fahy JV -
Future Research Directions in Asthma. An NHLBI Working Group Report.
American journal of respiratory and critical care medicine 2015 Levy BD, Noel PJ, Freemer MM, Cloutier MM, Georas SN, Jarjour NN, Ober C, Woodruff PG, Barnes KC, Bender BG, Camargo CA, Chupp GL, Denlinger LC, Fahy JV, Fitzpatrick AM, Fuhlbrigge A, Gaston BM, … -
Purpose of the Conference: 2015 Transatlantic Airway Conference.
Annals of the American Thoracic Society 2015 MacNee W, Fahy J, Nicod L, Kolls J -
The Role of Type 2 Inflammation in the Pathogenesis of Asthma Exacerbations.
Annals of the American Thoracic Society 2015 Dunican EM, Fahy JV -
Oxidation increases mucin polymer cross-links to stiffen airway mucus gels.
Science translational medicine 2015 Yuan S, Hollinger M, Lachowicz-Scroggins ME, Kerr SC, Dunican EM, Daniel BM, Ghosh S, Erzurum SC, Willard B, Hazen SL, Huang X, Carrington SD, Oscarson S, Fahy JV -
Type 2 inflammation in asthma--present in most, absent in many.
Nature reviews. Immunology 2015 Fahy JV -
Twenty-Ninth Transatlantic Airway Conference. Innate and adaptive immune responses in airway disease. Purpose of the conference.
Annals of the American Thoracic Society 2014 MacNee W, Fahy J, Nicod L, Kolls J -
A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production.
Nature immunology 2014 Simpson LJ, Patel S, Bhakta NR, Choy DF, Brightbill HD, Ren X, Wang Y, Pua HH, Baumjohann D, Montoya MM, Panduro M, Remedios KA, Huang X, Fahy JV, Arron JR, Woodruff PG, Ansel KM -
Accumulation of BDCA1⁺ dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma.
PloS one 2014 Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin JS -
Intelectin-1 is a prominent protein constituent of pathologic mucus associated with eosinophilic airway inflammation in asthma.
American journal of respiratory and critical care medicine 2014 Kerr SC, Carrington SD, Oscarson S, Gallagher ME, Solon M, Yuan S, Ahn JN, Dougherty RH, Finkbeiner WE, Peters MC, Fahy JV -
Asthma and the flu: a tricky two-step.
Immunology and cell biology 2014 Locksley RM, Fahy JV -
Asthma: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases.
Annals of the American Thoracic Society 2014 Jackson DJ, Hartert TV, Martinez FD, Weiss ST, Fahy JV -
A soluble fucose-specific lectin from Aspergillus fumigatus conidia--structure, specificity and possible role in fungal pathogenicity.
PloS one 2013 Houser J, Komarek J, Kostlanova N, Cioci G, Varrot A, Kerr SC, Lahmann M, Balloy V, Fahy JV, Chignard M, Imberty A, Wimmerova M -
Chair's summary: Mechanisms of relevance to clinical heterogeneity of asthma and chronic obstructive pulmonary disease.
Annals of the American Thoracic Society 2013 Fahy JV -
Purpose of the conference.
Annals of the American Thoracic Society 2013 MacNee W, Fahy J, Nicod L, Wanner A -
Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma.
The Journal of allergy and clinical immunology 2013 Peters MC, Mekonnen ZK, Yuan S, Bhakta NR, Woodruff PG, Fahy JV -
Type 2 immune responses in obese individuals with asthma.
American journal of respiratory and critical care medicine 2013 Peters MC, Fahy JV -
A qPCR-based metric of Th2 airway inflammation in asthma.
Clinical and translational allergy 2013 Bhakta NR, Solberg OD, Nguyen CP, Nguyen CN, Arron JR, Fahy JV, Woodruff PG -
An integrated nano-scale approach to profile miRNAs in limited clinical samples.
American journal of clinical and experimental immunology 2012 Seumois G, Vijayanand P, Eisley CJ, Omran N, Kalinke L, North M, Ganesan AP, Simpson LJ, Hunkapiller N, Moltzahn F, Woodruff PG, Fahy JV, Erle DJ, Djukanovic R, Blelloch R, Ansel KM -
P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy.
American journal of respiratory and critical care medicine 2012 Denlinger LC, Manthei DM, Seibold MA, Ahn K, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Chinchili VM, Fahy JV, Hawkins GA, Icitovic N, Israel E, Jarjour NN, King T, Kraft M, Lazarus SC, Lehman E, … -
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.
Proceedings of the National Academy of Sciences of the United States of America 2012 Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR -
Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial.
JAMA 2012 Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleecker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy JV, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M… -
Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients.
The Journal of allergy and clinical immunology 2012 Jia G, Erickson RW, Choy DF, Mosesova S, Wu LC, Solberg OD, Shikotra A, Carter R, Audusseau S, Hamid Q, Bradding P, Fahy JV, Woodruff PG, Harris JM, Arron JR, Bronchoscopic Exploratory Research Study … -
Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics.
BMC medical genomics 2012 Diez D, Goto S, Fahy JV, Erle DJ, Woodruff PG, Wheelock ÅM, Wheelock CE -
Cluster analysis of obesity and asthma phenotypes.
PloS one 2012 Sutherland ER, Goleva E, King TS, Lehman E, Stevens AD, Jackson LP, Stream AR, Fahy JV, Leung DY, Asthma Clinical Research Network -
Asthma outcomes: biomarkers.
The Journal of allergy and clinical immunology 2012 Szefler SJ, Wenzel S, Brown R, Erzurum SC, Fahy JV, Hamilton RG, Hunt JF, Kita H, Liu AH, Panettieri RA, Schleimer RP, Minnicozzi M -
A large subgroup of mild-to-moderate asthma is persistently noneosinophilic.
American journal of respiratory and critical care medicine 2012 McGrath KW, Icitovic N, Boushey HA, Lazarus SC, Sutherland ER, Chinchilli VM, Fahy JV, Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute -
Genetic association between human chitinases and lung function in COPD.
Human genetics 2011 Aminuddin F, Akhabir L, Stefanowicz D, Paré PD, Connett JE, Anthonisen NR, Fahy JV, Seibold MA, Burchard EG, Eng C, Gulsvik A, Bakke P, Cho MH, Litonjua A, Lomas DA, Anderson WH, Beaty TH, Crapo JD, … -
A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2011 Gordon ED, Sidhu SS, Wang ZE, Woodruff PG, Yuan S, Solon MC, Conway SJ, Huang X, Locksley RM, Fahy JV -
The airway epithelium as a regulator of Th2 responses in asthma.
American journal of respiratory and critical care medicine 2011 Fahy JV, Locksley RM -
The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose.
The Journal of allergy and clinical immunology 2011 Commins SP, James HR, Kelly LA, Pochan SL, Workman LJ, Perzanowski MS, Kocan KM, Fahy JV, Nganga LW, Ronmark E, Cooper PJ, Platts-Mills TA -
Hexaphenylbenzene as a rigid template for the straightforward syntheses of "star-shaped" glycodendrimers.
The Journal of organic chemistry 2010 Chabre YM, Brisebois PP, Abbassi L, Kerr SC, Fahy JV, Marcotte I, Roy R -
Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways.
Journal of immunology (Baltimore, Md. : 1950) 2010 Choy DF, Modrek B, Abbas AR, Kummerfeld S, Clark HF, Wu LC, Fedorowicz G, Modrusan Z, Fahy JV, Woodruff PG, Arron JR -
Airway mucus function and dysfunction.
The New England journal of medicine 2010 Fahy JV, Dickey BF -
Negative methacholine challenge tests in subjects who report physician-diagnosed asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2010 McGrath KW, Fahy JV -
A trial of clarithromycin for the treatment of suboptimally controlled asthma.
The Journal of allergy and clinical immunology 2010 Sutherland ER, King TS, Icitovic N, Ameredes BT, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Chinchilli VM, Craig TJ, Denlinger L, DiMango EA, Fahy JV, Israel E, Jarjour N, Kraft M, … -
Tiotropium bromide step-up therapy for adults with uncontrolled asthma.
The New England journal of medicine 2010 Peters SP, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Craig T, Denlinger L, Engle LL, DiMango EA, Fahy JV, Israel E, Jarjour N, Kazani … -
The H antigen at epithelial surfaces is associated with susceptibility to asthma exacerbation.
American journal of respiratory and critical care medicine 2010 Innes AL, McGrath KW, Dougherty RH, McCulloch CE, Woodruff PG, Seibold MA, Okamoto KS, Ingmundson KJ, Solon MC, Carrington SD, Fahy JV -
Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma.
Proceedings of the National Academy of Sciences of the United States of America 2010 Sidhu SS, Yuan S, Innes AL, Kerr S, Woodruff PG, Hou L, Muller SJ, Fahy JV -
Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma.
The Journal of allergy and clinical immunology 2010 Dougherty RH, Sidhu SS, Raman K, Solon M, Solberg OD, Caughey GH, Woodruff PG, Fahy JV -
Identifying clinical phenotypes of asthma: steps in the right direction.
American journal of respiratory and critical care medicine 2010 Fahy JV -
Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2009 Woodruff PG, Wolff M, Hohlfeld JM, Krug N, Dransfield MT, Sutherland ER, Criner GJ, Kim V, Prasse A, Nivens MC, Tetzlaff K, Heilker R, Fahy JV -
Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial.
Lancet (London, England) 2009 Wechsler ME, Kunselman SJ, Chinchilli VM, Bleecker E, Boushey HA, Calhoun WJ, Ameredes BT, Castro M, Craig TJ, Denlinger L, Fahy JV, Jarjour N, Kazani S, Kim S, Kraft M, Lazarus SC, Lemanske RF, … -
Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.
American journal of respiratory and critical care medicine 2009 Park SW, Verhaeghe C, Nguyenvu LT, Barbeau R, Eisley CJ, Nakagami Y, Huang X, Woodruff PG, Fahy JV, Erle DJ -
T-helper type 2-driven inflammation defines major subphenotypes of asthma.
American journal of respiratory and critical care medicine 2009 Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth LL, Arron JR, Fahy JV -
Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.
The Journal of biological chemistry 2009 Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, … -
Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma.
American journal of respiratory and critical care medicine 2009 Innes AL, Carrington SD, Thornton DJ, Kirkham S, Rousseau K, Dougherty RH, Raymond WW, Caughey GH, Muller SJ, Fahy JV -
Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies.
Proceedings of the American Thoracic Society 2009 Fahy JV -
Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009 Dougherty RH, Fahy JV -
Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit.
The Journal of allergy and clinical immunology 2008 Seibold MA, Donnelly S, Solon M, Innes A, Woodruff PG, Boot RG, Burchard EG, Fahy JV -
Predicting worsening asthma control following the common cold.
The European respiratory journal 2008 Walter MJ, Castro M, Kunselman SJ, Chinchilli VM, Reno M, Ramkumar TP, Avila PC, Boushey HA, Ameredes BT, Bleecker ER, Calhoun WJ, Cherniack RM, Craig TJ, Denlinger LC, Israel E, Fahy JV, Jarjour NN, … -
Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids.
Proceedings of the National Academy of Sciences of the United States of America 2007 Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto KR, Fahy JV -
Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma.
American journal of respiratory and critical care medicine 2007 Lazarus SC, Chinchilli VM, Rollings NJ, Boushey HA, Cherniack R, Craig TJ, Deykin A, DiMango E, Fish JE, Ford JG, Israel E, Kiley J, Kraft M, Lemanske RF, Leone FT, Martin RJ, Pesola GR, Peters SP, … -
The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial.
The Journal of allergy and clinical immunology 2007 Martin RJ, Szefler SJ, King TS, Kraft M, Boushey HA, Chinchilli VM, Craig TJ, Dimango EA, Deykin A, Fahy JV, Israel E, Lazarus SC, Lemanske RF, Leone FT, Pesola GR, Peters SP, Sorkness CA, Szwejbka LA… -
Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction.
Chest 2006 Innes AL, Woodruff PG, Ferrando RE, Donnelly S, Dolganov GM, Lazarus SC, Fahy JV -
Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma.
American journal of respiratory and critical care medicine 2006 Deykin A, Wechsler ME, Boushey HA, Chinchilli VM, Kunselman SJ, Craig TJ, DiMango E, Fahy JV, Kraft M, Leone F, Lazarus SC, Lemanske RF, Martin RJ, Pesola GR, Peters SP, Sorkness CA, Szefler SJ, … -
Characterizing mucous cell remodeling in cystic fibrosis: relationship to neutrophils.
American journal of respiratory and critical care medicine 2006 Hays SR, Fahy JV -
Anti-IgE: lessons learned from effects on airway inflammation and asthma exacerbation.
The Journal of allergy and clinical immunology 2006 Fahy JV -
Effects of multiday exposure to ozone on airway inflammation as determined using sputum induction.
Environmental health perspectives 2006 Ratto J, Wong H, Liu J, Fahy J, Boushey H, Solomon C, Balmes J -
beta-Adrenergic receptor polymorphisms and response to salmeterol.
American journal of respiratory and critical care medicine 2005 Wechsler ME, Lehman E, Lazarus SC, Lemanske RF, Boushey HA, Deykin A, Fahy JV, Sorkness CA, Chinchilli VM, Craig TJ, DiMango E, Kraft M, Leone F, Martin RJ, Peters SP, Szefler SJ, Liu W, Israel E, … -
Dissecting asthma using focused transgenic modeling and functional genomics.
The Journal of allergy and clinical immunology 2005 Kuperman DA, Lewis CC, Woodruff PG, Rodriguez MW, Yang YH, Dolganov GM, Fahy JV, Erle DJ -
Induced sputum evaluation in microwave popcorn production workers.
Chest 2005 Akpinar-Elci M, Stemple KJ, Enright PL, Fahy JV, Bledsoe TA, Kreiss K, Weissman DN -
Daily versus as-needed corticosteroids for mild persistent asthma.
The New England journal of medicine 2005 Boushey HA, Sorkness CA, King TS, Sullivan SD, Fahy JV, Lazarus SC, Chinchilli VM, Craig TJ, Dimango EA, Deykin A, Fagan JK, Fish JE, Ford JG, Kraft M, Lemanske RF, Leone FT, Martin RJ, Mauger EA, … -
Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids.
The Journal of allergy and clinical immunology 2005 Deykin A, Lazarus SC, Fahy JV, Wechsler ME, Boushey HA, Chinchilli VM, Craig TJ, Dimango E, Kraft M, Leone F, Lemanske RF, Martin RJ, Pesola GR, Peters SP, Sorkness CA, Szefler SJ, Israel E, Asthma … -
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial.
Lancet (London, England) 2004 Israel E, Chinchilli VM, Ford JG, Boushey HA, Cherniack R, Craig TJ, Deykin A, Fagan JK, Fahy JV, Fish J, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Liggett SB, Martin RJ, Mitra N, Peters SP, … -
Adenosine up-regulation of the mucin gene, MUC2, in asthma.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004 McNamara N, Gallup M, Khong A, Sucher A, Maltseva I, Fahy J, Basbaum C -
Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma.
American journal of respiratory and critical care medicine 2004 Djukanovic R, Wilson SJ, Kraft M, Jarjour NN, Steel M, Chung KF, Bao W, Fowler-Taylor A, Matthews J, Busse WW, Holgate ST, Fahy JV -
Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression.
American journal of respiratory and critical care medicine 2004 Woodruff PG, Dolganov GM, Ferrando RE, Donnelly S, Hays SR, Solberg OD, Carter R, Wong HH, Cadbury PS, Fahy JV -
Effect of a single dose of the selectin inhibitor TBC1269 on early and late asthmatic responses.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2004 Avila PC, Boushey HA, Wong H, Grundland H, Liu J, Fahy JV -
Applying stereology to measure thickness of the basement membrane zone in bronchial biopsy specimens.
The Journal of allergy and clinical immunology 2003 Ferrando RE, Nyengaard JR, Hays SR, Fahy JV, Woodruff PG -
Effects of individual self-management education on clinical, biological, and adherence outcomes in asthma.
The American journal of medicine 2003 Janson SL, Fahy JV, Covington JK, Paul SM, Gold WM, Boushey HA -
Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroids.
Chest 2003 Kraft M, Martin RJ, Lazarus SC, Fahy JV, Boushey HA, Lemanske RF, Szefler SJ, Asthma Clinical Research Network -
The role of mucus in fatal asthma.
The American journal of medicine 2003 Hays SR, Fahy JV -
Goblet cell and mucin gene abnormalities in asthma.
Chest 2002 Fahy JV -
Airway remodeling in asthma.
Seminars in respiratory and critical care medicine 2002 Woodruff PG, Fahy JV -
Systemic effect comparisons of six inhaled corticosteroid preparations.
American journal of respiratory and critical care medicine 2002 Martin RJ, Szefler SJ, Chinchilli VM, Kraft M, Dolovich M, Boushey HA, Cherniack RM, Craig TJ, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kunselman SJ, Lazarus SC, Lemanske RF, Peters … -
A role for neutrophils in asthma?
The American journal of medicine 2002 Woodruff PG, Fahy JV -
Significant variability in response to inhaled corticosteroids for persistent asthma.
The Journal of allergy and clinical immunology 2002 Szefler SJ, Martin RJ, King TS, Boushey HA, Cherniack RM, Chinchilli VM, Craig TJ, Dolovich M, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kiley J, Kraft M, Lazarus SC, Lemanske RF, … -
Practical management of acute asthma in adults.
Respiratory care 2002 Hallstrand TS, Fahy JV -
Quality control within the Asthma Clinical Research Network.
Controlled clinical trials 2001 Martin RJ, Kephart DK, Dyer AM, Fahy J, Kraft M, Asthma Clinical Trials Network -
Epithelial desquamation in asthma.
American journal of respiratory and critical care medicine 2001 Ordoñez CL, Fahy JV -
Remodeling of the airway epithelium in asthma.
American journal of respiratory and critical care medicine 2001 Fahy JV -
Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma.
The Journal of allergy and clinical immunology 2001 Woodruff PG, Khashayar R, Lazarus SC, Janson S, Avila P, Boushey HA, Segal M, Fahy JV -
A novel method of gene transcript profiling in airway biopsy homogenates reveals increased expression of a Na+-K+-Cl- cotransporter (NKCC1) in asthmatic subjects.
Genome research 2001 Dolganov GM, Woodruff PG, Novikov AA, Zhang Y, Ferrando RE, Szubin R, Fahy JV -
Asthma: prevalence, pathogenesis, and prospects for novel therapies.
JAMA 2001 Woodruff PG, Fahy JV -
Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial.
JAMA 2001 Lemanske RF, Sorkness CA, Mauger EA, Lazarus SC, Boushey HA, Fahy JV, Drazen JM, Chinchilli VM, Craig T, Fish JE, Ford JG, Israel E, Kraft M, Martin RJ, Nachman SA, Peters SP, Spahn JD, Szefler SJ, … -
Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial.
JAMA 2001 Lazarus SC, Boushey HA, Fahy JV, Chinchilli VM, Lemanske RF, Sorkness CA, Kraft M, Fish JE, Peters SP, Craig T, Drazen JM, Ford JG, Israel E, Martin RJ, Mauger EA, Nachman SA, Spahn JD, Szefler SJ, … -
Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study.
American journal of respiratory and critical care medicine 2001 Fahy JV, Boushey HA, Lazarus SC, Mauger EA, Cherniack RM, Chinchilli VM, Craig TJ, Drazen JM, Ford JG, Fish JE, Israel E, Kraft M, Lemanske RF, Martin RJ, McLean D, Peters SP, Sorkness C, Szefler SJ, … -
The utility of peak flow, symptom scores, and beta-agonist use as outcome measures in asthma clinical research.
Chest 2001 Leone FT, Mauger EA, Peters SP, Chinchilli VM, Fish JE, Boushey HA, Cherniack RM, Drazen JM, Fahy JV, Ford J, Israel E, Lazarus SC, Lemanske RF, Martin RJ, McGeady SJ, Sorkness C, Szefler SJ, Asthma … -
"Reactive airways disease". A lazy term of uncertain meaning that should be abandoned.
American journal of respiratory and critical care medicine 2001 Fahy JV, O'Byrne PM -
Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression.
American journal of respiratory and critical care medicine 2001 Ordoñez CL, Khashayar R, Wong HH, Ferrando R, Wu R, Hyde DM, Hotchkiss JA, Zhang Y, Novikov A, Dolganov G, Fahy JV -
Relationship of epidermal growth factor receptors to goblet cell production in human bronchi.
American journal of respiratory and critical care medicine 2001 Takeyama K, Fahy JV, Nadel JA -
Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma.
International archives of allergy and immunology 2001 Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF, Martin RJ, McLean DE, Peters SP, … -
Histopathology of fatal asthma: drowning in mucus.
Pediatric pulmonology 2001 Rubin BK, Tomkiewicz R, Fahy JV, Green FH -
Use of biological markers of airway inflammation to detect the efficacy of nurse-delivered asthma education.
Heart & lung : the journal of critical care 2001 Janson S, Hardie G, Fahy J, Boushey H -
Epithelial desquamation in asthma: artifact or pathology?
American journal of respiratory and critical care medicine 2000 Ordoñez C, Ferrando R, Hyde DM, Wong HH, Fahy JV -
Targeting cytokines in asthma therapy: round one.
Lancet (London, England) 2000 Boushey HA, Fahy JV -
The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma.
American journal of respiratory and critical care medicine 2000 Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF, Martin RJ, McLean DE, Peters SP, … -
Predictors of late asthmatic response. Logistic regression and classification tree analyses.
American journal of respiratory and critical care medicine 2000 Avila PC, Segal MR, Wong HH, Boushey HA, Fahy JV -
Reducing IgE levels as a strategy for the treatment of asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000 Fahy JV -
Cytotoxic prenylxanthones from Garcinia bracteata.
Journal of natural products 2000 Thoison O, Fahy J, Dumontet V, Chiaroni A, Riche C, Tri MV, Sévenet T -
Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance.
American journal of respiratory and critical care medicine 2000 Ordoñez CL, Shaughnessy TE, Matthay MA, Fahy JV -
Airway inflammation and remodeling in asthma.
Current opinion in pulmonary medicine 2000 Fahy JV, Corry DB, Boushey HA -
Low- and high-dose fluticasone propionate in asthma; effects during and after treatment.
The European respiratory journal 2000 Gershman NH, Wong HH, Liu JT, Fahy JV -
Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells.
The Journal of clinical investigation 1999 Longphre M, Li D, Gallup M, Drori E, Ordoñez CL, Redman T, Wenzel S, Bice DE, Fahy JV, Basbaum C -
Effect of aerosolized anti-IgE (E25) on airway responses to inhaled allergen in asthmatic subjects.
American journal of respiratory and critical care medicine 1999 Fahy JV, Cockcroft DW, Boulet LP, Wong HH, Deschesnes F, Davis EE, Ruppel J, Su JQ, Adelman DC -
Fractional analysis of sequential induced sputum samples during sputum induction: evidence that different lung compartments are sampled at different time points.
The Journal of allergy and clinical immunology 1999 Gershman NH, Liu H, Wong HH, Liu JT, Fahy JV -
The effect of methacholine challenge on the cellular composition of induced sputum.
The Journal of allergy and clinical immunology 1999 Gershman NH, Fahy JV -
Neutrophil elastase and elastase-rich cystic fibrosis sputum degranulate human eosinophils in vitro.
The American journal of physiology 1999 Liu H, Lazarus SC, Caughey GH, Fahy JV -
A safe, simple, standardized method should be used for sputum induction for research purposes.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998 Fahy JV -
Effect of low-dose beclomethasone dipropionate on asthma control and airway inflammation.
The European respiratory journal 1998 Fahy JV, Boushey HA -
Targeting IgE with monoclonal antibodies: the future is now.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998 Fahy JV, Boushey HA -
Methods for sputum induction and analysis of induced sputum: a method for assessing airway inflammation in asthma.
The European respiratory journal. Supplement 1998 Kips JC, Fahy JV, Hargreave FE, Ind PW, in't Veen JC -
An evaluation of colchicine as an alternative to inhaled corticosteriods in moderate asthma. National Heart, Lung, and Blood Institute's Asthma Clinical Research Network.
American journal of respiratory and critical care medicine 1997 Fish JE, Peters SP, Chambers CV, McGeady SJ, Epstein KR, Boushey HA, Cherniack RM, Chinchilli VM, Drazen JM, Fahy JV, Hurd SS, Israel E, Lazarus SC, Lemanske RF, Martin RJ, Mauger EA, Sorkness C, … -
Safety of one method of sputum induction in asthmatic subjects.
American journal of respiratory and critical care medicine 1997 Wong HH, Fahy JV -
The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects.
American journal of respiratory and critical care medicine 1997 Fahy JV, Fleming HE, Wong HH, Liu JT, Su JQ, Reimann J, Fick RB, Boushey HA -
Similar RANTES levels in healthy and asthmatic airways by immunoassay and in situ hybridization.
American journal of respiratory and critical care medicine 1997 Fahy JV, Figueroa DJ, Wong HH, Liu JT, Abrams JS -
Comparison of two methods of collecting induced sputum in asthmatic subjects.
The European respiratory journal 1996 Gershman NH, Wong HH, Liu JT, Mahlmeister MJ, Fahy JV -
Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. Asthma Clinical Research Network.
The New England journal of medicine 1996 Drazen JM, Israel E, Boushey HA, Chinchilli VM, Fahy JV, Fish JE, Lazarus SC, Lemanske RF, Martin RJ, Peters SP, Sorkness C, Szefler SJ -
High-resolution computed tomography of airway changes after induced bronchoconstriction and bronchodilation in asthmatic volunteers.
Academic radiology 1996 Kee ST, Fahy JV, Chen DR, Gamsu G -
Controversies involving inhaled beta-agonists and inhaled corticosteroids in the treatment of asthma.
Clinics in chest medicine 1995 Fahy JV, Boushey HA -
Basic mechanisms of asthma.
Environmental health perspectives 1995 Boushey HA, Fahy JV -
Effect of an NK1 receptor antagonist (CP-99,994) on hypertonic saline-induced bronchoconstriction and cough in male asthmatic subjects.
American journal of respiratory and critical care medicine 1995 Fahy JV, Wong HH, Geppetti P, Reis JM, Harris SC, Maclean DB, Nadel JA, Boushey HA -
Analysis of induced sputum after air and ozone exposures in healthy subjects.
Environmental research 1995 Fahy JV, Wong HH, Liu JT, Boushey HA -
Comparison of samples collected by sputum induction and bronchoscopy from asthmatic and healthy subjects.
American journal of respiratory and critical care medicine 1995 Fahy JV, Wong H, Liu J, Boushey HA -
Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation.
The Journal of allergy and clinical immunology 1995 Fahy JV, Kim KW, Liu J, Boushey HA -
Cystic fibrosis sputum induces a secretory response from airway gland serous cells that can be prevented by neutrophil protease inhibitors.
The European respiratory journal 1995 Schuster A, Fahy JV, Ueki I, Nadel JA -
Chronic pulmonary disorders in sickle cell disease: findings at thin-section CT.
Radiology 1994 Aquino SL, Gamsu G, Fahy JV, Claster S, Embury SH, Mentzer WC, Vichinsky EP -
Analysis of induced sputum to examine the effects of prednisone on airway inflammation in asthmatic subjects.
The Journal of allergy and clinical immunology 1994 Claman DM, Boushey HA, Liu J, Wong H, Fahy JV -
Analysis of cellular and biochemical constituents of induced sputum after allergen challenge: a method for studying allergic airway inflammation.
The Journal of allergy and clinical immunology 1994 Fahy JV, Liu J, Wong H, Boushey HA -
Use of mucin antibodies and cDNA probes to quantify hypersecretion in vivo in human airways.
American journal of respiratory cell and molecular biology 1994 Steiger D, Fahy J, Boushey H, Finkbeiner WE, Basbaum C -
Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects.
The American review of respiratory disease 1993 Fahy JV, Liu J, Wong H, Boushey HA -
Disappearance of eosinophils from bronchoalveolar lavage fluid after patient education and high-dose inhaled corticosteroids: a case report.
Heart & lung : the journal of critical care 1993 Janson-Bjerklie S, Fahy J, Geaghan S, Golden J -
Lack of effect of prophylactic aerosolized pentamidine on the detection of Pneumocystis carinii in induced sputum or bronchoalveolar lavage specimens.
Archives of pathology & laboratory medicine 1993 Ng VL, Geaghan SM, Leoung G, Shiboski S, Fahy J, Schnapp L, Yajko DM, Hopewell PC, Hadley WK -
Markers of mucus secretion and DNA levels in induced sputum from asthmatic and from healthy subjects.
The American review of respiratory disease 1993 Fahy JV, Steiger DJ, Liu J, Basbaum CB, Finkbeiner WE, Boushey HA -
Chronic eosinophilic pneumonia. A long-term follow-up of 12 patients.
Chest 1993 Naughton M, Fahy J, FitzGerald MX -
Mucus hypersecretion in bronchiectasis. The role of neutrophil proteases.
The American review of respiratory disease 1992 Fahy JV, Schuster A, Ueki I, Boushey HA, Nadel JA -
Effect of aerosolized pentamidine prophylaxis on the clinical severity and diagnosis of Pneumocystis carinii pneumonia.
The American review of respiratory disease 1992 Fahy JV, Chin DP, Schnapp LM, Steiger DJ, Schaumberg TH, Geaghan SM, Klein JS, Hopewell PC -
Toxoplasma gondii pneumonitis in patients infected with the human immunodeficiency virus.
Archives of internal medicine 1992 Schnapp LM, Geaghan SM, Campagna A, Fahy J, Steiger D, Ng V, Hadley WK, Hopewell PC, Stansell JD -
Aminoglycoside induced ototoxicity in patients with cystic fibrosis.
Irish journal of medical science 1991 Mulherin D, Fahy J, Grant W, Keogan M, Kavanagh B, FitzGerald M -
"Slurry lung": a report of three cases.
Thorax 1991 Fahy JV, Walley T, Gibney RT, McCabe M, FitzGerald MX -
A chest radiograph scoring system in adult cystic fibrosis: correlation with pulmonary function.
Clinical radiology 1991 O'Laoide RM, Fahy J, Coffey M, Ward K, Malone D, Fitzgerald MX, Masterson J -
Bacteraemia and fungaemia in adults with cystic fibrosis.
The Journal of infection 1991 Fahy JV, Keoghan MT, Crummy EJ, FitzGerald MX -
Haemopericardium and cardiac tamponade complicating pulmonary lymphangioleiomyomatosis.
Thorax 1991 Fahy J, Toner M, O'Sullivan J, FitzGerald MX