John Ambrose, MD, FACC
Professor
Cardiology - Fresno
School of Medicine

Professor Program Director, Cardiovascular Fellowship UCSF Fresno

Dr. John Ambrose is an internationally renowned expert in coronary artery disease and is one of the great pioneers in acute coronary syndromes. He has published extensively and his work has laid the foundation for the current theories on unstable angina, myocardial infarction and the vulnerable plaque, among others. Before coming to Fresno, Dr. Ambrose was the Director of the Cardiovascular Center at Saint Vincent Catholic Medical Centers in Manhattan. Before that, he was the Director of Cardiac Catheterization at Mount Sinai Medical Center in New York. He has been included in every edition of “Best Doctors in America.” Dr. Ambrose sang professionally in New York and continues to sing with his wife with the Fresno Grand Opera.

• The Reply.
  The American journal of medicine 2021 Ambrose JA
• The Look Inside: Is it Clinically Relevant?
  JACC. Cardiovascular imaging 2020 Ambrose JA, Poosti K
• Reducing Tobacco-Related Morbidity and Mortality-A Call to Action.
  JAMA cardiology 2020 Ambrose JA, Najafi A, Barua R
• Reducing Tobacco-Related Disability in Chronic Smokers.
  The American journal of medicine 2020 Ambrose JA, Najafi A, Jain V, Muller JE, Ranka S, Barua RS
• Anatomic or functional testing in stable patients with suspected CAD: contemporary role of cardiac CT in the ISCHEMIA trial era.
  The international journal of cardiovascular imaging 2020 Rodriguez-Granillo GA, Nieman K, Carrascosa P, Campisi R, Ambrose JA
• Misdiagnosis of Type II Myocardial Infarction.
  Journal of the American College of Cardiology 2019 Saleh MA, Ambrose JA, Poosti K, Rajyaguru C, Sargsyan M, Najafi A, Bhullar A, Sandhu U, Hashmi M, Sandhu C
• Environmental Tobacco Smoke and Cardiovascular Disease.
  International journal of environmental research and public health 2018 DiGiacomo SI, Jazayeri MA, Barua RS, Ambrose JA
• Understanding myocardial infarction.
  F1000Research 2018 Saleh M, Ambrose JA
• Strategies for the Prevention of Coronary Artery Disease Complications: Can We Do Better?
  The American journal of medicine 2018 Ambrose JA, Najafi A
• In-Hospital Outcomes of Percutaneous Coronary Intervention in America's Safety Net: Insights From the NCDR Cath-PCI Registry.
  JACC. Cardiovascular interventions 2017 Acharya T, Salisbury AC, Spertus JA, Kennedy KF, Bhullar A, Reddy HKK, Joshi BK, Ambrose JA
• Normalization of Testosterone Levels After Testosterone Replacement Therapy Is Not Associated With Reduced Myocardial Infarction in Smokers.
  Mayo Clinic proceedings. Innovations, quality & outcomes 2017 Oni OA, Sharma R, Chen G, Sharma M, Gupta K, Dawn B, Sharma R, Parashara D, Savin VJ, Cherian G, Ambrose JA, Barua RS
• Normalization of Testosterone Levels After Testosterone Replacement Therapy Is Associated With Decreased Incidence of Atrial Fibrillation.
  Journal of the American Heart Association 2017 Sharma R, Oni OA, Gupta K, Sharma M, Sharma R, Singh V, Parashara D, Kamalakar S, Dawn B, Chen G, Ambrose JA, Barua RS
• Finding the High-Risk Patient in Primary Prevention Is Not as Easy as a Conventional Risk Score!
  The American journal of medicine 2016 Ambrose JA, Acharya T, Roberts MJ
• Left Atrial Area and Right Ventricle Dimensions in Non-gated Axial Chest CT can Differentiate Pulmonary Hypertension Due to Left Heart Disease from Other Causes.
  Journal of cardiovascular computed tomography 2016 Katikireddy CK, Singh M, Muhyieddeen K, Acharya T, Ambrose JA, Samim A
• Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men.
  European heart journal 2015 Sharma R, Oni OA, Gupta K, Chen G, Sharma M, Dawn B, Sharma R, Parashara D, Savin VJ, Ambrose JA, Barua RS
• A Single Controlled Exposure to Secondhand Smoke May Not Alter Thrombogenesis or Trigger Platelet Activation.
  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2015 Srikanth S, Sy F, Kotak K, Kiel RG, Bajwa M, Tandon A, Loures-Vale AA, Aftab W, Tringali S, Ambrose JA
• Pathophysiology of coronary artery disease leading to acute coronary syndromes.
  F1000prime reports 2015 Ambrose JA, Singh M
• Do advances in technology in the catheterization laboratory for percutaneous coronary interventions negatively influence an operator's technique, decision making, and judgment?
  JACC. Cardiovascular interventions 2014 Ambrose JA
• Reducing acute coronary events: the solution is not so difficult!
  The American journal of medicine 2014 Ambrose JA, Acharya T
• Femoral micropuncture or routine introducer study (FEMORIS).
  Cardiology 2014 Ambrose JA, Lardizabal J, Mouanoutoua M, Buhari CF, Berg R, Joshi B, El-Sherief K, Wessel R, Singh M, Kiel R
• Are the culprit lesions severely stenotic?
  JACC. Cardiovascular imaging 2013 Niccoli G, Stefanini GG, Capodanno D, Crea F, Ambrose JA, Berg R
• Frequency of Takotsubo cardiomyopathy in postmenopausal women presenting with an acute coronary syndrome.
  The American journal of cardiology 2013 Sy F, Basraon J, Zheng H, Singh M, Richina J, Ambrose JA
• Mechanisms of coronary thrombosis in cigarette smoke exposure.
  Arteriosclerosis, thrombosis, and vascular biology 2013 Barua RS, Ambrose JA
• Managing coronary thrombus in the cath lab during PCI.
  Current cardiology reviews 2012 Ambrose JA
• Pathophysiology of coronary thrombus formation and adverse consequences of thrombus during PCI.
  Current cardiology reviews 2012 Srikanth S, Ambrose JA
• Angiographic correlates in type 1 and 2 MI by the universal definition.
  JACC. Cardiovascular imaging 2012 Ambrose JA, Loures-Vale A, Javed U, Buhari CF, Aftab W
• Computed tomographic angiography for localizing the site of plaque disruption/thrombus: is detection so complex?
  Circulation. Cardiovascular imaging 2011 Ambrose JA, Srikanth S
• Acute myocardial infarction and the five-chambered heart.
  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2011 Lardizabal JA, Javed U, Ambrose JA
• Does angiographic response to wiring of totally occluded vessels predict outcomes in ST-segment elevation myocardial infarction?
  JACC. Cardiovascular interventions 2011 Ambrose JA, Buhari CF
• Acute cigarette smoke exposure reduces clot lysis--association between altered fibrin architecture and the response to t-PA.
  Thrombosis research 2010 Barua RS, Sy F, Srikanth S, Huang G, Javed U, Buhari C, Margosan D, Aftab W, Ambrose JA
• Evaluation of plaque composition by intravascular ultrasound "virtual histology": the impact of dense calcium on the measurement of necrotic tissue.
  EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 2010 Sales FJ, Falcão BA, Falcão JL, Ribeiro EE, Perin MA, Horta PE, Spadaro AG, Ambrose JA, Martinez EE, Furuie SS, Lemos PA
• The balance between anti-ischemic efficacy and bleeding risk of antithrombotic therapy in percutaneous coronary intervention: a Yin-Yang paradigm.
  The Journal of invasive cardiology 2010 Lardizabal JA, Joshi BK, Ambrose JA
• Vulnerable plaques and patients: improving prediction of future coronary events.
  The American journal of medicine 2010 Ambrose JA, Srikanth S
• Effects of cigarette smoke exposure on clot dynamics and fibrin structure: an ex vivo investigation.
  Arteriosclerosis, thrombosis, and vascular biology 2009 Barua RS, Sy F, Srikanth S, Huang G, Javed U, Buhari C, Margosan D, Ambrose JA
• Preventing future acute coronary events: is the target the so-called vulnerable plaque or the high-risk or vulnerable patient?
  Current opinion in cardiology 2009 Ambrose JA, Srikanth S
• Frequency of elevated troponin I and diagnosis of acute myocardial infarction.
  The American journal of cardiology 2009 Javed U, Aftab W, Ambrose JA, Wessel RJ, Mouanoutoua M, Huang G, Barua RS, Weilert M, Sy F, Thatai D
• The editor's roundtable: the vulnerable plaque.
  The American journal of cardiology 2008 Friedewald VE, Ambrose JA, Stone GW, Roberts WC, Willerson JT
• In search of the "vulnerable plaque": can it be localized and will focal regional therapy ever be an option for cardiac prevention?
  Journal of the American College of Cardiology 2008 Ambrose JA
• Methamphetamine-associated acute left ventricular dysfunction: a variant of stress-induced cardiomyopathy.
  Cardiology 2007 Srikanth S, Barua R, Ambrose J
• Human myocardium preconditioning during successive balloon inflations: irrelevant influence of both collateral recruitment and clinical pre-intervention interference.
  EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 2006 Pimentel WA, Martinez EE, Ambrose JA, Mathias W, Arruda A, Horta PE, Ribeiro EE, Esteves A, Lemos PA, Ramires JA
• Myocardial perfusion scintigraphy to predict outcomes after coronary stenting.
  EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 2006 Zalc S, Ambrose JA, Lemos PA, Ribeiro EE, Soares J, Giorgi MC, Esteves-Filho A, Horta PE, Meneghetti JC, Ramires JA, Martinez EE
• Myocardial ischemia and infarction.
  Journal of the American College of Cardiology 2006 Ambrose JA
• Impact of completeness of percutaneous coronary intervention revascularization on long-term outcomes in the stent era.
  Circulation 2006 Hannan EL, Racz M, Holmes DR, King SB, Walford G, Ambrose JA, Sharma S, Katz S, Clark LT, Jones RH
• A risk score to predict in-hospital mortality for percutaneous coronary interventions.
  Journal of the American College of Cardiology 2006 Wu C, Hannan EL, Walford G, Ambrose JA, Holmes DR, King SB, Clark LT, Katz S, Sharma S, Jones RH
• Sirolimus- and taxol-eluting stents differ towards intimal hyperplasia and re-endothelialization.
  The Journal of invasive cardiology 2005 Liuzzo JP, Ambrose JA, Coppola JT
• Early prognostic usefulness of C-reactive protein added to the Thrombolysis In Myocardial Infarction risk score in acute coronary syndromes.
  The American journal of cardiology 2005 Foussas SG, Zairis MN, Lyras AG, Patsourakos NG, Tsirimpis VG, Katsaros K, Beldekos DJ, Handanis SM, Mytas DZ, Karidis KS, Tselioti PG, Prekates AA, Ambrose JA
• Volume-outcome relationships for percutaneous coronary interventions in the stent era.
  Circulation 2005 Hannan EL, Wu C, Walford G, King SB, Holmes DR, Ambrose JA, Sharma S, Katz S, Clark LT, Jones RH
• Proton pump inhibitors for patients with coronary artery disease associated with reduced chest pain, emergency department visits, and hospitalizations.
  Clinical cardiology 2005 Liuzzo JP, Ambrose JA, Diggs P
• Chest pain from gastroesophageal reflux disease in patients with coronary artery disease.
  Cardiology in review 2005 Liuzzo JP, Ambrose JA
• Triple valve repair for rheumatic heart disease.
  Journal of cardiac surgery 2005 Liuzzo JP, Shin YT, Lucariello R, Klapholz M, Lang SJ, Braff R, Guan H, Coppola JT, Ambrose JA
• Plaque rupture and intracoronary thrombus in nonculprit vessels: an eyewitness account.
  Journal of the American College of Cardiology 2005 Ambrose JA, D'Agate DJ
• Classification of systemic therapies for potential stabilization of the vulnerable plaque to prevent acute myocardial infarction.
  The American journal of cardiology 2005 Ambrose JA, D'Agate DJ
• Preprocedural plasma C-reactive protein levels, postprocedural creatine kinase-MB release, and long-term prognosis after successful coronary stenting (four-year results from the GENERATION study).
  The American journal of cardiology 2005 Zairis MN, Ambrose JA, Ampartzidou O, Lyras AG, Manousakis SJ, Makrygiannis SS, Beldekos DJ, Devoe MC, Fakiolas CN, Prekates AA, Olympios CD, Argyrakis SK, Foussas SG, GENERATION Study Group
• The evolving role of glycoprotein (GP) IIb/IIIa receptor blockade during percutaneous coronary intervention of saphenous vein bypass grafts.
  The Journal of invasive cardiology 2004 D'Agate DJ, Patel S, Coppola JT, Ambrose JA
• The pathophysiology of cigarette smoking and cardiovascular disease: an update.
  Journal of the American College of Cardiology 2004 Ambrose JA, Barua RS
• Predictors of troponin elevation after percutaneous coronary intervention.
  The American journal of cardiology 2004 Mandadi VR, DeVoe MC, Ambrose JA, Prakash AM, Varshneya N, Gould RB, Nguyen TH, Geagea JP, Radojevic JA, Sehhat K, Barua RS
• Value of low-dose dobutamine addition to routine dual isotope gated SPECT myocardial imaging in patients with healed myocardial infarction or abnormal wall thickening by echocardiogram.
  The American journal of cardiology 2004 Heiba SI, Abdel-Dayem HM, Gould R, Bernaski E, Morlote M, El-Zeftawy H, Ambrose JA
• Luminal recovery from six to twelve months after implantation of "thicker strut" coronary stents.
  The American journal of cardiology 2004 Meireles GC, Lemos PA, Ambrose JA, Ribeiro E, Horta PE, Perin M, Ramires JA, Martinez EE
• Pilot study of oral rapamycin to prevent restenosis in patients undergoing coronary stent therapy: Argentina Single-Center Study (ORAR Trial).
  The Journal of invasive cardiology 2003 Rodriguez AE, Alemparte MR, Vigo CF, Pereira CF, Llaurado C, Russo M, Virmani R, Ambrose JA
• Identification of vulnerable atherosclerotic plaques.
  Expert review of cardiovascular therapy 2003 Staniloae CS, Ambrose JA
• Frequency of and outcome of acute coronary syndromes in patients with human immunodeficiency virus infection.
  The American journal of cardiology 2003 Ambrose JA, Gould RB, Kurian DC, DeVoe MC, Pearlstein NB, Coppola JT, Siegal FP
• Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase: an in vitro demonstration in human coronary artery endothelial cells.
  Circulation 2003 Barua RS, Ambrose JA, Srivastava S, DeVoe MC, Eales-Reynolds LJ
• C-reactive protein and ST-segment monitoring by continuous 12-lead electrocardiogram in patients with primary unstable angina pectoris.
  The American journal of cardiology 2003 Zairis MN, Ambrose JA, Papadaki OA, Manousakis SJ, Stefanidis AS, DeVoe MC, Handanis SM, Olympios CD, Foussas SG
• Peripheral conduction disease in left ventricular dysfunction.
  The American journal of cardiology 2003 Puttappa R, Raia F, Bhat S, Braff R, Mandadi VR, Barua RS, DeVoe MC, Boal BH, Ambrose JA
• The impact of plasma levels of C-reactive protein, lipoprotein (a) and homocysteine on the long-term prognosis after successful coronary stenting: The Global Evaluation of New Events and Restenosis After Stent Implantation Study.
  Journal of the American College of Cardiology 2002 Zairis MN, Ambrose JA, Manousakis SJ, Stefanidis AS, Papadaki OA, Bilianou HI, DeVoe MC, Fakiolas CN, Pissimissis EG, Olympios CD, Foussas SG, Global Evaluation of New Events and Restenosis After …
• Acute coronary lesions and troponin elevation in unstable angina pectoris or non-ST elevation acute myocardial infarction.
  The American journal of cardiology 2002 Ambrose JA, Gould RB, Zairis MN, DeVoe MC, Nguyen TH, Geagea JP, Arias JH, Prakash AM, Varshneya N, Meraj P, Barua RS
• Smoking is associated with altered endothelial-derived fibrinolytic and antithrombotic factors: an in vitro demonstration.
  Circulation 2002 Barua RS, Ambrose JA, Saha DC, Eales-Reynolds LJ
• Heavy and light cigarette smokers have similar dysfunction of endothelial vasoregulatory activity: an in vivo and in vitro correlation.
  Journal of the American College of Cardiology 2002 Barua RS, Ambrose JA, Eales-Reynolds LJ, DeVoe MC, Zervas JG, Saha DC
• A new paradigm for plaque stabilization.
  Circulation 2002 Ambrose JA, Martinez EE
• Unstable Angina and Non-ST-Segment Elevation Myocardial Infarction.
  Current treatment options in cardiovascular medicine 2002 Ambrose JA, Tai Z