Johannes Morstein, PhD
Postdoctoral Scholar
Cellular Molecular Pharmacology
School of Medicine

Publications (47)

Top publication keywords:
LipidsSilanesPalladiumAzo CompoundsPhotochemical ProcessesPharmacologyCarbon MonoxideLipopeptidesras ProteinsLysophospholipidsReceptor, Serotonin, 5-HT2ACeramidesCopperrab GTP-Binding ProteinsSphingolipids

• Optical control of sphingolipid biosynthesis using photoswitchable sphingosines.
  Journal of lipid research 2024 Kol M, Novak AJE, Morstein J, Schröer C, Sokoya T, Mensing S, Korneev SM, Trauner D, Holthuis JCM
• Neuroprotective effect of neuron-specific deletion of the C16 ceramide synthetic enzymes in an animal model of multiple sclerosis.
  Glia 2024 Amatruda M, Marechal D, Gacias M, Wentling M, Turpin-Nolan S, Morstein J, Moniruzzaman M, Brüning JC, Haughey NJ, Trauner DH, Casaccia P
• Optical control of sphingolipid biosynthesis using photoswitchable sphingosines.
  bioRxiv : the preprint server for biology 2024 Kol M, Novak AJE, Morstein J, Schröer C, Sokoya T, Mensing S, Korneev SM, Trauner D, Holthuis JCM
• Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist.
  Proceedings of the National Academy of Sciences of the United States of America 2024 Liccardo F, Morstein J, Lin TY, Pampel J, Lang D, Shokat KM, Irannejad R
• Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.
  Cell 2024 Morstein J, Bowcut V, Fernando M, Yang Y, Zhu L, Jenkins ML, Evans JT, Guiley KZ, Peacock DM, Krahnke S, Lin Z, Taran KA, Huang BJ, Stephen AG, Burke JE, Lightstone FC, Shokat KM

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• Optical Control of Proteasomal Protein Degradation with a Photoswitchable Lipopeptide.
  Angewandte Chemie (International ed. in English) 2024 Morstein J, Amatuni A, Shuster A, Kuttenlochner W, Ko T, Abegg D, Groll M, Adibekian A, Renata H, Trauner DH
• Selective activation of intracellular β1AR using a spatially restricted antagonist.
  bioRxiv : the preprint server for biology 2023 Liccardo F, Morstein J, Lin TY, Pampel J, Shokat KM, Irannejad R
• Direct Modulators of K-Ras-Membrane Interactions.
  ACS chemical biology 2023 Morstein J, Shrestha R, Van QN, López CA, Arora N, Tonelli M, Liang H, Zhou Y, Hancock JF, Stephen AG, Turbyville TJ, Shokat KM
• Development of Light-Activated LXR Agonists.
  ChemMedChem 2023 Mukhopadhyay TK, Willems S, Arp CJ, Morstein J, Haake CT, Merk D, Trauner D
• Mapping light distribution in tissue by using MRI-detectable photosensitive liposomes.
  Nature biomedical engineering 2022 Simon J, Schwalm M, Morstein J, Trauner D, Jasanoff A
• Optical Control of Translation with a Puromycin Photoswitch.
  Journal of the American Chemical Society 2022 Ko T, Oliveira MM, Alapin JM, Morstein J, Klann E, Trauner D
• Photoswitchable Isoprenoid Lipids Enable Optical Control of Peptide Lipidation.
  ACS chemical biology 2022 Morstein J, Bader T, Cardillo AL, Schackmann J, Ashok S, Hougland JL, Hrycyna CA, Trauner DH, Distefano MD
• Medium-Chain Lipid Conjugation Facilitates Cell-Permeability and Bioactivity.
  Journal of the American Chemical Society 2022 Morstein J, Capecchi A, Hinnah K, Park B, Petit-Jacques J, Van Lehn RC, Reymond JL, Trauner D
• Postsynthetic Photocontrol of Giant Liposomes via Fusion-Based Photolipid Doping.
  Langmuir : the ACS journal of surfaces and colloids 2022 Pritzl SD, Morstein J, Kahler S, Konrad DB, Trauner D, Lohmüller T
• Optical control of neuronal activities with photoswitchable nanovesicles.
  Nano research 2022 Xiong H, Alberto KA, Youn J, Taura J, Morstein J, Li X, Wang Y, Trauner D, Slesinger PA, Nielsen SO, Qin Z
• Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile.
  Journal of the American Chemical Society 2022 Zhang Z, Morstein J, Ecker AK, Guiley KZ, Shokat KM
• Photopharmacological control of cell signaling with photoswitchable lipids.
  Current opinion in pharmacology 2022 Mukhopadhyay TK, Morstein J, Trauner D
• Photoswitchable Serotonins for Optical Control of the 5-HT2A Receptor.
  Angewandte Chemie (International ed. in English) 2022 Morstein J, Romano G, Hetzler BE, Plante A, Haake C, Levitz J, Trauner D
• Optical Control of Glycerolipids and Sphingolipids.
  Chimia 2021 Trauner D, Morstein J
• Cholesterol and sphingomyelin are critical for Fcγ receptor-mediated phagocytosis of Cryptococcus neoformans by macrophages.
  The Journal of biological chemistry 2021 Bryan AM, You JK, Li G, Kim J, Singh A, Morstein J, Trauner D, Pereira de Sá N, Normile TG, Farnoud AM, London E, Del Poeta M
• Optical Control of Phosphatidic Acid Signaling.
  ACS central science 2021 Tei R, Morstein J, Shemet A, Trauner D, Baskin JM
• A Photohormone for Light-Dependent Control of PPARα in Live Cells.
  Journal of medicinal chemistry 2021 Willems S, Morstein J, Hinnah K, Trauner D, Merk D
• How Photoswitchable Lipids Affect the Order and Dynamics of Lipid Bilayers and Embedded Proteins.
  Journal of the American Chemical Society 2021 Doroudgar M, Morstein J, Becker-Baldus J, Trauner D, Glaubitz C
• Optimized Photoactivatable Lipid Nanoparticles Enable Red Light Triggered Drug Release.
  Small (Weinheim an der Bergstrasse, Germany) 2021 Chander N, Morstein J, Bolten JS, Shemet A, Cullis PR, Trauner D, Witzigmann D
• Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.
  Gastroenterology 2021 Chen Y, Wang ZL, Yeo M, Zhang QJ, López-Romero AE, Ding HP, Zhang X, Zeng Q, Morales-Lázaro SL, Moore C, Jin YA, Yang HH, Morstein J, Bortsov A, Krawczyk M, Lammert F, Abdelmalek M, Diehl AM, …
• Short Photoswitchable Ceramides Enable Optical Control of Apoptosis.
  ACS chemical biology 2021 Morstein J, Kol M, Novak AJE, Feng S, Khayyo S, Hinnah K, Li-Purcell N, Pan G, Williams BM, Riezman H, Atilla-Gokcumen GE, Holthuis JCM, Trauner D
• Evolutionarily related small viral fusogens hijack distinct but modular actin nucleation pathways to drive cell-cell fusion.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Chan KMC, Arthur AL, Morstein J, Jin M, Bhat A, Schlesinger D, Son S, Stevens DA, Drubin DG, Fletcher DA
• Photoswitchable Lipids.
  Chembiochem : a European journal of chemical biology 2020 Morstein J, Impastato AC, Trauner D
• Metabolic tuning of inhibition regulates hippocampal neurogenesis in the adult brain.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Wang X, Liu H, Morstein J, Novak AJE, Trauner D, Xiong Q, Yu Y, Ge S
• Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor γ (PPARγ).
  Journal of medicinal chemistry 2020 Hinnah K, Willems S, Morstein J, Heering J, Hartrampf FWW, Broichhagen J, Leippe P, Merk D, Trauner D
• Ligand-Directed Approach to Activity-Based Sensing: Developing Palladacycle Fluorescent Probes That Enable Endogenous Carbon Monoxide Detection.
  Journal of the American Chemical Society 2020 Morstein J, Höfler D, Ueno K, Jurss JW, Walvoord RR, Bruemmer KJ, Rezgui SP, Brewer TF, Saitoe M, Michel BW, Chang CJ
• Optical Control of Lysophosphatidic Acid Signaling.
  Journal of the American Chemical Society 2020 Morstein J, Dacheux MA, Norman DD, Shemet A, Donthamsetti PC, Citir M, Frank JA, Schultz C, Isacoff EY, Parrill AL, Tigyi GJ, Trauner D
• Photopharmacological control of lipid function.
  Methods in enzymology 2020 Morstein J, Trauner D
• A Photoswitchable Inhibitor of the Human Serotonin Transporter.
  ACS chemical neuroscience 2020 Cheng B, Morstein J, Ladefoged LK, Maesen JB, Schiøtt B, Sinning S, Trauner D
• Carbon Monoxide, a Retrograde Messenger Generated in Postsynaptic Mushroom Body Neurons, Evokes Noncanonical Dopamine Release.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Ueno K, Morstein J, Ofusa K, Naganos S, Suzuki-Sawano E, Minegishi S, Rezgui SP, Kitagishi H, Michel BW, Chang CJ, Horiuchi J, Saitoe M
• Optical control of the nuclear bile acid receptor FXR with a photohormone.
  Chemical science 2019 Morstein J, Trads JB, Hinnah K, Willems S, Barber DM, Trauner M, Merk D, Trauner D
• Fixing a Photosensitizer Unlocks and Localizes Its Lethality.
  ACS central science 2019 Trauner D, Morstein J
• New players in phototherapy: photopharmacology and bio-integrated optoelectronics.
  Current opinion in chemical biology 2019 Morstein J, Trauner D
• Optical control of sphingosine-1-phosphate formation and function.
  Nature chemical biology 2019 Morstein J, Hill RZ, Novak AJE, Feng S, Norman DD, Donthamsetti PC, Frank JA, Harayama T, Williams BM, Parrill AL, Tigyi GJ, Riezman H, Isacoff EY, Bautista DM, Trauner D
• Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course.
  EBioMedicine 2019 Castro K, Ntranos A, Amatruda M, Petracca M, Kosa P, Chen EY, Morstein J, Trauner D, Watson CT, Kiebish MA, Bielekova B, Inglese M, Katz Sand I, Casaccia P
• Mapping the Azolog Space Enables the Optical Control of New Biological Targets.
  ACS central science 2019 Morstein J, Awale M, Reymond JL, Trauner D
• In Vivo Photopharmacology.
  Chemical reviews 2018 Hüll K, Morstein J, Trauner D
• Total Synthesis of (±)-Exotine B.
  Organic letters 2018 Cheng B, Volpin G, Morstein J, Trauner D
• Correction to "Copper-Mediated C-N Coupling of Arylsilanes with Nitrogen Nucleophiles".
  Organic letters 2016 Morstein J, Kalkman ED, Bold C, Cheng C, Hartwig JF
• Copper-Mediated C-N Coupling of Arylsilanes with Nitrogen Nucleophiles.
  Organic letters 2016 Morstein J, Kalkman ED, Bold C, Cheng C, Hartwig JF
• Trifluoromethylation of Arylsilanes with [(phen)CuCF3 ].
  Angewandte Chemie (International ed. in English) 2016 Morstein J, Hou H, Cheng C, Hartwig JF
• The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations.
  EMBO molecular medicine 2016 Diederichs S, Bartsch L, Berkmann JC, Fröse K, Heitmann J, Hoppe C, Iggena D, Jazmati D, Karschnia P, Linsenmeier M, Maulhardt T, Möhrmann L, Morstein J, Paffenholz SV, Röpenack P, Rückert T, Sandig L…