Joel Karliner, MD
Professor Emeritus
Medicine
School of Medicine

Education & Training

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• Clinical Fellowship School of Medicine - Cardiology University of California, San Francisco

Websites

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• Profile at clinpharm.ucsf.edu (clinpharm.ucsf.edu)

Grants and Projects

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• Immune Modulation and Cardiac Remodeling, NIH, 2016-2021
• Diet-Induced Insulin Resistance and Myocardial Ischemia in Pigs, NIH, 1994-2016
• Sphingosine 1-phosphate and cardioprotection, NIH, 2009-2014
• Prevention of heart failure and death by sphingolipids: outcomes and mechanisms., NIH, 2009-2013
• Mechanisms of Cardioprotection in Ischemia and Failure, NIH, 2002-2008
• Protection From Cardiac Reperfusion Injury by Ethanol, NIH, 1996-2008

Publications (71)

Top publication keywords:
MyocardiumSphingosineMyocardial Reperfusion InjuryMyocytes, CardiacIschemic Preconditioning, MyocardialPQQ CofactorMitochondria, HeartCardiotonic AgentsLysophospholipidsPhosphotransferases (Alcohol Group Acceptor)Propylene GlycolsMatrix Metalloproteinase 2Reperfusion InjuryVincristineReceptors, Lysosphingolipid

• Human plasma platelet-derived exosomes: effects of aspirin.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Goetzl EJ, Goetzl L, Karliner JS, Tang N, Pulliam L
• Immunosuppression With FTY720 Reverses Cardiac Dysfunction in Hypomorphic ApoE Mice Deficient in SR-BI Expression That Survive Myocardial Infarction Caused by Coronary Atherosclerosis.
  Journal of cardiovascular pharmacology 2016 Luk FS, Kim RY, Li K, Ching D, Wong DK, Joshi SK, Imhof I, Honbo N, Hoover H, Zhu BQ, Lovett DH, Karliner JS, Raffai RL
• IL-15: a novel prosurvival signaling pathway in cardiomyocytes.
  Journal of cardiovascular pharmacology 2014 Yeghiazarians Y, Honbo N, Imhof I, Woods B, Aguilera V, Ye J, Boyle AJ, Karliner JS
• Arsonists and firefighters: the perpetual inflammatory civil war for survival.
  Circulation 2014 Karliner JS
• Selected aspects of cellular responses in heart failure.
  Journal of cardiovascular pharmacology 2014 Karliner JS

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• The immunosuppressant FTY720 prolongs survival in a mouse model of diet-induced coronary atherosclerosis and myocardial infarction.
  Journal of cardiovascular pharmacology 2014 Wang G, Kim RY, Imhof I, Honbo N, Luk FS, Li K, Kumar N, Zhu BQ, Eberlé D, Ching D, Karliner JS, Raffai RL
• N-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure.
  PloS one 2013 Lovett DH, Mahimkar R, Raffai RL, Cape L, Zhu BQ, Jin ZQ, Baker AJ, Karliner JS
• Sphingolipids in cardiovascular and cerebrovascular systems: Pathological implications and potential therapeutic targets.
  World journal of cardiology 2013 Kawabori M, Kacimi R, Karliner JS, Yenari MA
• FTY720 postconditions isolated perfused heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning.
  Medical science monitor basic research 2013 Vessey DA, Li L, Imhof I, Honbo N, Karliner JS
• Sphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progress.
  Biochimica et biophysica acta 2012 Karliner JS
• A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity.
  PloS one 2012 Lovett DH, Mahimkar R, Raffai RL, Cape L, Maklashina E, Cecchini G, Karliner JS
• Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats.
  PloS one 2011 Bauerly K, Harris C, Chowanadisai W, Graham J, Havel PJ, Tchaparian E, Satre M, Karliner JS, Rucker RB
• A sphingosine kinase form 2 knockout sensitizes mouse myocardium to ischemia/reoxygenation injury and diminishes responsiveness to ischemic preconditioning.
  Oxidative medicine and cellular longevity 2011 Vessey DA, Li L, Jin ZQ, Kelley M, Honbo N, Zhang J, Karliner JS
• S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart.
  American journal of physiology. Heart and circulatory physiology 2011 Bandhuvula P, Honbo N, Wang GY, Jin ZQ, Fyrst H, Zhang M, Borowsky AD, Dillard L, Karliner JS, Saba JD
• Minocycline protects cardiac myocytes against simulated ischemia–reperfusion injury by inhibiting poly(ADP-ribose) polymerase-1.
  Journal of cardiovascular pharmacology 2010 Tao R, Kim SH, Honbo N, Karliner JS, Alano CC
• Transgenic expression of matrix metalloproteinase-2 induces coronary artery ectasia.
  International journal of experimental pathology 2010 Dahi S, Karliner JS, Sarkar R, Lovett DH
• Vincristine attenuates N-methyl-N'-nitro-N-nitrosoguanidine-induced poly-(ADP) ribose polymerase activity in cardiomyocytes.
  Journal of cardiovascular pharmacology 2010 Zhang J, Chatterjee K, Alano CC, Kalinowski MA, Honbo N, Karliner JS
• High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate.
  American journal of physiology. Heart and circulatory physiology 2010 Tao R, Hoover HE, Honbo N, Kalinowski M, Alano CC, Karliner JS, Raffai R
• Cardioprotective activity of a novel and potent competitive inhibitor of lactate dehydrogenase.
  FEBS letters 2010 Kotlyar AB, Randazzo A, Honbo N, Jin ZQ, Karliner JS, Cecchini G
• Doxorubicin cardiomyopathy.
  Cardiology 2009 Chatterjee K, Zhang J, Honbo N, Karliner JS
• Lessons from the besotted heart.
  Journal of the American College of Cardiology 2009 Karliner JS
• Sphingosine 1-phosphate is an important endogenous cardioprotectant released by ischemic pre- and postconditioning.
  American journal of physiology. Heart and circulatory physiology 2009 Vessey DA, Li L, Honbo N, Karliner JS
• Cardiomyocyte S1P1 receptor-mediated extracellular signal-related kinase signaling and desensitization.
  Journal of cardiovascular pharmacology 2009 Tao R, Hoover HE, Zhang J, Honbo N, Alano CC, Karliner JS
• Myocardial survival signaling in response to stem cell transplantation.
  Journal of the American College of Surgeons 2009 Li H, Malhotra D, Yeh CC, Tu R, Zhu BQ, Birger N, Wisneski A, Cha J, Karliner JS, Mann MJ
• Lipid signalling in cardiovascular pathophysiology.
  Cardiovascular research 2009 Karliner JS, Brown JH
• Sphingosine kinase and sphingosine 1-phosphate in cardioprotection.
  Journal of cardiovascular pharmacology 2009 Karliner JS
• Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction.
  American journal of physiology. Heart and circulatory physiology 2009 Yeh CC, Li H, Malhotra D, Huang MC, Zhu BQ, Goetzl EJ, Vessey DA, Karliner JS, Mann MJ
• Sphingosine kinase regulation and cardioprotection.
  Cardiovascular research 2008 Karliner JS
• Cardiac transgenic matrix metalloproteinase-2 expression induces myxomatous valve degeneration: a potential model of mitral valve prolapse disease.
  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2008 Mahimkar R, Nguyen A, Mann M, Yeh CC, Zhu BQ, Karliner JS, Lovett DH
• Combined sphingosine, S1P and ischemic postconditioning rescue the heart after protracted ischemia.
  Biochemical and biophysical research communications 2008 Vessey DA, Li L, Kelley M, Karliner JS
• Vincristine attenuates doxorubicin cardiotoxicity.
  Biochemical and biophysical research communications 2008 Chatterjee K, Zhang J, Tao R, Honbo N, Karliner JS
• Ischaemic postconditioning protects isolated mouse hearts against ischaemia/reperfusion injury via sphingosine kinase isoform-1 activation.
  Cardiovascular research 2008 Jin ZQ, Karliner JS, Vessey DA
• Sphingosine can pre- and post-condition heart and utilizes a different mechanism from sphingosine 1-phosphate.
  Journal of biochemical and molecular toxicology 2008 Vessey DA, Li L, Kelley M, Zhang J, Karliner JS
• Differences among cell types in NAD(+) compartmentalization: a comparison of neurons, astrocytes, and cardiac myocytes.
  Journal of neuroscience research 2007 Alano CC, Tran A, Tao R, Ying W, Karliner JS, Swanson RA
• Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy.
  American journal of physiology. Heart and circulatory physiology 2007 McCloskey DT, Turcato S, Wang GY, Turnbull L, Zhu BQ, Bambino T, Nguyen AP, Lovett DH, Nissenson RA, Karliner JS, Baker AJ
• Redox-dependent change of nucleotide affinity to the active site of the mammalian complex I.
  Biochemistry 2007 Grivennikova VG, Kotlyar AB, Karliner JS, Cecchini G, Vinogradov AD
• Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia.
  American journal of physiology. Heart and circulatory physiology 2007 Zhang J, Honbo N, Goetzl EJ, Chatterjee K, Karliner JS, Gray MO
• Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes.
  Biochemical and biophysical research communications 2007 Tao R, Karliner JS, Simonis U, Zheng J, Zhang J, Honbo N, Alano CC
• Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse.
  Circulation 2007 Bao X, Lu CM, Liu F, Gu Y, Dalton ND, Zhu BQ, Foster E, Chen J, Karliner JS, Ross J, Simpson PC, Ziegler MG
• Acute vincristine pretreatment protects adult mouse cardiac myocytes from oxidative stress.
  Journal of molecular and cellular cardiology 2007 Chatterjee K, Zhang J, Honbo N, Simonis U, Shaw R, Karliner JS
• A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury.
  Cardiovascular research 2007 Jin ZQ, Zhang J, Huang Y, Hoover HE, Vessey DA, Karliner JS
• Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunction.
  Biochemical and biophysical research communications 2007 Zhou HZ, Ma X, Gray MO, Zhu BQ, Nguyen AP, Baker AJ, Simonis U, Cecchini G, Lovett DH, Karliner JS
• Adult cardiac fibroblasts null for sphingosine kinase-1 exhibit growth dysregulation and an enhanced proinflammatory response.
  Journal of molecular and cellular cardiology 2007 Kacimi R, Vessey DA, Honbo N, Karliner JS
• Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes.
  Cardiovascular research 2007 Tao R, Zhang J, Vessey DA, Honbo N, Karliner JS
• Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart.
  Journal of biochemical and molecular toxicology 2007 Vessey DA, Kelley M, Zhang J, Li L, Tao R, Karliner JS
• Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction.
  American journal of physiology. Heart and circulatory physiology 2006 Bergman MR, Teerlink JR, Mahimkar R, Li L, Zhu BQ, Nguyen A, Dahi S, Karliner JS, Lovett DH
• Role of sphingosine kinase activity in protection of heart against ischemia reperfusion injury.
  Medical science monitor : international medical journal of experimental and clinical research 2006 Vessey DA, Kelley M, Li L, Huang Y, Zhou HZ, Zhu BQ, Karliner JS
• Toward solving the riddle: the enigma becomes less mysterious.
  Circulation research 2006 Karliner JS
• Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.
  Cardiovascular research 2006 Jin ZQ, Karliner JS
• Comparison of pyrroloquinoline quinone and/or metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia/reperfusion injury.
  Journal of cardiovascular pharmacology and therapeutics 2006 Zhu BQ, Simonis U, Cecchini G, Zhou HZ, Li L, Teerlink JR, Karliner JS
• Cardiac ischemia-reperfusion injury induces matrix metalloproteinase-2 expression through the AP-1 components FosB and JunB.
  American journal of physiology. Heart and circulatory physiology 2006 Alfonso-Jaume MA, Bergman MR, Mahimkar R, Cheng S, Jin ZQ, Karliner JS, Lovett DH
• Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator.
  American journal of physiology. Heart and circulatory physiology 2005 Turnbull L, Zhou HZ, Swigart PM, Turcato S, Karliner JS, Conklin BR, Simpson PC, Baker AJ
• Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility.
  Cardiovascular research 2005 Wang GY, Bergman MR, Nguyen AP, Turcato S, Swigart PM, Rodrigo MC, Simpson PC, Karliner JS, Lovett DH, Baker AJ
• A novel strong competitive inhibitor of complex I.
  FEBS letters 2005 Kotlyar AB, Karliner JS, Cecchini G
• Off the shelf but not mass produced.
  Chemistry & biology 2005 Karliner JS
• Symbols within words: have we neglected the AdeNOsine A2 receptor?
  Cardiovascular research 2005 Karliner JS
• A rapid radioassay for sphingosine kinase.
  Analytical biochemistry 2005 Vessey DA, Kelley M, Karliner JS
• MnSOD in mouse heart: acute responses to ischemic preconditioning and ischemia-reperfusion injury.
  American journal of physiology. Heart and circulatory physiology 2005 Jin ZQ, Zhou HZ, Cecchini G, Gray MO, Karliner JS
• Pyrroloquinoline quinone (PQQ) decreases myocardial infarct size and improves cardiac function in rat models of ischemia and ischemia/reperfusion.
  Cardiovascular drugs and therapy 2004 Zhu BQ, Zhou HZ, Teerlink JR, Karliner JS
• Sphingosine kinase activation mediates ischemic preconditioning in murine heart.
  Circulation 2004 Jin ZQ, Goetzl EJ, Karliner JS
• Mechanisms of cardioprotection by lysophospholipids.
  Journal of cellular biochemistry 2004 Karliner JS
• Molecular determinants of responses to myocardial ischemia/reperfusion injury: focus on hypoxia-inducible and heat shock factors.
  Cardiovascular research 2004 Chi NC, Karliner JS
• Effect of oxygen on activation state of complex I and lack of oxaloacetate inhibition of complex II in Langendorff perfused rat heart.
  FEBS letters 2004 Maklashina E, Kotlyar AB, Karliner JS, Cecchini G
• Second hand smoke stimulates tumor angiogenesis and growth.
  Cancer cell 2003 Zhu BQ, Heeschen C, Sievers RE, Karliner JS, Parmley WW, Glantz SA, Cooke JP
• Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytes.
  The Journal of biological chemistry 2003 Graeler MH, Kong Y, Karliner JS, Goetzl EJ
• Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function.
  Journal of the renin-angiotensin-aldosterone system : JRAAS 2003 Zhu BQ, Sievers RE, Browne AE, Lee RJ, Chatterjee K, Grossman W, Karliner JS, Parmley WW
• A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers.
  The Biochemical journal 2003 Bergman MR, Cheng S, Honbo N, Piacentini L, Karliner JS, Lovett DH
• Effect of anoxia/reperfusion on the reversible active/de-active transition of NADH-ubiquinone oxidoreductase (complex I) in rat heart.
  Biochimica et biophysica acta 2002 Maklashina E, Sher Y, Zhou HZ, Gray MO, Karliner JS, Cecchini G
• Moderate alcohol consumption induces sustained cardiac protection by activating PKC-epsilon and Akt.
  American journal of physiology. Heart and circulatory physiology 2002 Zhou HZ, Karliner JS, Gray MO
• Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts.
  American journal of physiology. Heart and circulatory physiology 2002 Jin ZQ, Zhou HZ, Zhu P, Honbo N, Mochly-Rosen D, Messing RO, Goetzl EJ, Karliner JS, Gray MO
• Lysophospholipids and the cardiovascular system.
  Biochimica et biophysica acta 2002 Karliner JS