Joel Ernst, MD
Professor
Medicine
School of Medicine
The goal of my research is to provide the mechanistic basis for development of effective vaccines against tuberculosis.
Awards
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- McFadden Memorial Lecturer, University of Nebraska, 2016
- Dean's Honors Lecturer, New York University School of Medicine, 2015
- Honorary Doctorate (M.D., honoris causa), Linköping University, Sweden, 2013
- Elected Fellow, American Academy of Microbiologists, 2010
- Thaler Lecturer, Aeras Global TB Vaccine Foundation, 2009
- Elected Member, Association of American Physicians, 2009
- Kirby Lecturer, University of Washington, 2009
Education & Training
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- Diversity, Equity, and Inclusion Champion Training University of California 2018
- Leukocyte cell biology University of California, San Francisco 06/1986
- Hematology and Oncology University of California, San Francisco 06/1984
- Infectious Diseases University of California, San Francisco 06/1982
- Internal Medicine University of California, San Francisco 06/1981
- M.D. Medicine University of Nebraska 05/1978
Grants and Projects
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- Childhood ?Omics? and Mycobacterium tuberculosis-derived BiOsignatures (COMBO) for TB diagnosis in high HIV prevalence settings, NIH, 2020-2025
- Live Imaging of Immunity to M. tuberculosis, NIH, 2021-2022
- Host genetic diversity, T cell responses, and outcomes of TB, NIH, 2020-2022
- Training Program in Immunology and Inflammation, NIH, 2012-2022
- Host genetic diversity, mononuclear phagocytes, and outcomes of TB, NIH, 2020-2022
- A novel approach for deep phenotyping the CD4 T cell response to Mycobacterium Tuberculosis, NIH, 2020-2022
- Role of antigen-specific T cell responses in the control of TB, NIH, 2014-2021
- Antigen export in M. tuberculosis evasion of CD4 T cells, NIH, 2016-2021
- Cellular and Bacterial Dynamics in Tuberculosis, NIH, 2001-2020
- Epitope-specific T cell activation to complement TB immunity and vaccine efficacy, NIH, 2014-2016
- Mycobacterium tuberculosis antigen diversity, NIH, 2010-2016
- Mycobacterium tuberculosis evasion of CD4+ T cells in vivo, NIH, 2010-2015
- M. tuberculosis evasion of immune effector mechanisms, NIH, 2000-2010
- Type I Interferons in Immunity to Tuberculosis, NIH, 2004-2010
- Mycobacterium tuberculosis evasion of CD4+ T cells in vivo, NIH, 2009
- Tuberculosis Immunity: Essential Host Genes, NIH, 2002-2005
- Mycobacterium Tuberculosis;induced Macrophage Signalling, NIH, 1993-2003
- Molecular Mechanisms of Neutrophil Secretion, NIH, 1996-2001
- Role of Synexin in Leukocyte Degranulation, NIH, 1986-1991
- Role of Synexin in Leukocyte Degranulation, NIH, 1986-1989
Publications (134)
Top publication keywords:
Interferon Type IAcyltransferasesAntigen PresentationImmune EvasionTuberculosis VaccinesBacterial ProteinsMycobacterium tuberculosisCD4-Positive T-LymphocytesDendritic CellsTuberculosis, PulmonaryInterferon-gammaMacrophagesTuberculosisAntigens, BacterialEpitopes, T-Lymphocyte
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High-parameter phenotypic characterization reveals a subset of human Th17 cells that preferentially produce IL17 against M. tuberculosis antigen.
bioRxiv : the preprint server for biology 2024 Ogongo P, Tran A, Marzan F, Gingrich D, Krone M, Aweeka F, Lindestam Arlehamn CS, Martin JN, Deeks SG, Hunt PW, Ernst JD -
Rare Variable M. tuberculosis Antigens induce predominant Th17 responses in human infection.
bioRxiv : the preprint server for biology 2024 Ogongo P, Wassie L, Tran A, Columbus D, Sharling L, Ouma G, Ouma SG, Bobosha K, Lindestam Arlehamn CS, Gandhi NR, Auld SC, Rengarajan J, Day CL, Altman JD, Blumberg HM, Ernst JD, TBRU ASTRa Study … -
A teenage girl with altered mental status and paraparesis.
Journal of clinical tuberculosis and other mycobacterial diseases 2024 Miyakawa R, Louie J, Keh C, Chen L, Javid B, Ernst JD, Goswami N, Chow FC -
selSeq: A method for the enrichment of non-polyadenylated RNAs including enhancer and long non-coding RNAs for sequencing.
PloS one 2023 Limberis JD, Nalyvayko A, Ernst JD, Metcalfe JZ -
A simple, single-tube overlapping amplicon-targeted Illumina sequencing assay.
PloS one 2023 Limberis JD, Nalyvayko A, Ernst JD, Metcalfe JZ
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Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.
Research square 2023 Zheng W, Chang IC, Limberis J, Budzik J, Zha BS, Howard Z, Chen L, Ernst J -
Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.
bioRxiv : the preprint server for biology 2023 Zheng W, Chang IC, Limberis J, Budzik JM, Zha BS, Howard Z, Chen L, Ernst JD -
Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania.
PLoS pathogens 2023 Zwyer M, Rutaihwa LK, Windels E, Hella J, Menardo F, Sasamalo M, Sommer G, Schmülling L, Borrell S, Reinhard M, Dötsch A, Hiza H, Stritt C, Sikalengo G, Fenner L, De Jong BC, Kato-Maeda M, Jugheli L, … -
Spatial mapping reveals granuloma diversity and histopathological superstructure in human tuberculosis.
The Journal of experimental medicine 2023 Sawyer AJ, Patrick E, Edwards J, Wilmott JS, Fielder T, Yang Q, Barber DL, Ernst JD, Britton WJ, Palendira U, Chen X, Feng CG -
Circularization of rv0678 for Genotypic Bedaquiline Resistance Testing of Mycobacterium tuberculosis.
Microbiology spectrum 2023 Limberis JD, Nalyvayko A, Ernst JD, Metcalfe JZ -
Finding antigens for TB vaccines: the good, the bad and the useless.
Nature medicine 2023 Ogongo P, Ernst JD -
High-resolution imaging of protein secretion at the single-cell level using plasmon-enhanced FluoroDOT assay.
Cell reports methods 2022 Seth A, Mittal E, Luan J, Kolla S, Mazer MB, Joshi H, Gupta R, Rathi P, Wang Z, Morrissey JJ, Ernst JD, Portal-Celhay C, Morley SC, Philips JA, Singamaneni S -
Bacterial Strain-Dependent Dissociation of Cell Recruitment and Cell-to-Cell Spread in Early M. tuberculosis Infection.
mBio 2022 Zha BS, Desvignes L, Fergus TJ, Cornelius A, Cheng TY, Moody DB, Ernst JD -
Repeated Plasmodium falciparum infection in humans drives the clonal expansion of an adaptive γδ T cell repertoire.
Science translational medicine 2021 von Borstel A, Chevour P, Arsovski D, Krol JMM, Howson LJ, Berry AA, Day CL, Ogongo P, Ernst JD, Nomicos EYH, Boddey JA, Giles EM, Rossjohn J, Traore B, Lyke KE, Williamson KC, Crompton PD, Davey MS -
A Framework to Identify Antigen-Expanded T Cell Receptor Clusters Within Complex Repertoires.
Frontiers in immunology 2021 Ceglia V, Kelley EJ, Boyle AS, Zurawski S, Mead HL, Harms CE, Blanck JP, Flamar AL, Kirschman JH, Ogongo P, Ernst JD, Levy Y, Zurawski G, Altin JA -
A defective viral genome strategy elicits broad protective immunity against respiratory viruses.
Cell 2021 Xiao Y, Lidsky PV, Shirogane Y, Aviner R, Wu CT, Li W, Zheng W, Talbot D, Catching A, Doitsh G, Su W, Gekko CE, Nayak A, Ernst JD, Brodsky L, Brodsky E, Rousseau E, Capponi S, Bianco S, Nakamura R, … -
Toward Comprehensive Plasma Proteomics by Orthogonal Protease Digestion.
Journal of proteome research 2021 Fossati A, Richards AL, Chen KH, Jaganath D, Cattamanchi A, Ernst JD, Swaney DL -
Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease.
Nature immunology 2021 Nathan A, Beynor JI, Baglaenko Y, Suliman S, Ishigaki K, Asgari S, Huang CC, Luo Y, Zhang Z, Lopez K, Lindestam Arlehamn CS, Ernst JD, Jimenez J, Calderón RI, Lecca L, Van Rhijn I, Moody DB, Murray MB… -
Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins.
Cell reports 2021 Hiatt J, Cavero DA, McGregor MJ, Zheng W, Budzik JM, Roth TL, Haas KM, Wu D, Rathore U, Meyer-Franke A, Bouzidi MS, Shifrut E, Lee Y, Kumar VE, Dang EV, Gordon DE, Wojcechowskyj JA, Hultquist JF, … -
Schistosoma mansoni Infection Is Associated With a Higher Probability of Tuberculosis Disease in HIV-Infected Adults in Kenya.
Journal of acquired immune deficiency syndromes (1999) 2021 McLaughlin TA, Nizam A, Hayara FO, Ouma GS, Campbell A, Khayumbi J, Ongalo J, Ouma SG, Shah NS, Altman JD, Kaushal D, Rengarajan J, Ernst JD, Blumberg HM, Waller LA, Gandhi NR, Day CL, Benkeser D -
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance.
Nature biotechnology 2020 Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong … -
Tryptophan catabolism reflects disease activity in human tuberculosis.
JCI insight 2020 Collins JM, Siddiqa A, Jones DP, Liu K, Kempker RR, Nizam A, Shah NS, Ismail N, Ouma SG, Tukvadze N, Li S, Day CL, Rengarajan J, Brust JC, Gandhi NR, Ernst JD, Blumberg HM, Ziegler TR -
Test performance evaluation of SARS-CoV-2 serological assays.
medRxiv : the preprint server for health sciences 2020 Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong … -
Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barré Syndrome in Brazil.
PLoS neglected tropical diseases 2019 Rivera-Correa J, de Siqueira IC, Mota S, do Rosário MS, Pereira de Jesus PA, Alcantara LCJ, Ernst JD, Rodriguez A -
Dynamics of Mycobacterium tuberculosis Ag85B Revealed by a Sensitive Enzyme-Linked Immunosorbent Assay.
mBio 2019 Ernst JD, Cornelius A, Bolz M -
Mononuclear cell dynamics in M. tuberculosis infection provide opportunities for therapeutic intervention.
PLoS pathogens 2018 Norris BA, Ernst JD -
Limited Antimycobacterial Efficacy of Epitope Peptide Administration Despite Enhanced Antigen-Specific CD4 T-Cell Activation.
The Journal of infectious diseases 2018 Ernst JD, Cornelius A, Desvignes L, Tavs J, Norris BA -
Mechanisms of M. tuberculosis Immune Evasion as Challenges to TB Vaccine Design.
Cell host & microbe 2018 Ernst JD -
Float Like Bacilli, STING Like a B: Type I Interferons in Tuberculosis.
American journal of respiratory and critical care medicine 2018 Ernst JD -
A High Throughput Whole Blood Assay for Analysis of Multiple Antigen-Specific T Cell Responses in Human Mycobacterium tuberculosis Infection.
Journal of immunology (Baltimore, Md. : 1950) 2018 Whatney WE, Gandhi NR, Lindestam Arlehamn CS, Nizam A, Wu H, Quezada MJ, Campbell A, Allana S, Kabongo MM, Khayumbi J, Muchiri B, Ongalo J, Tonui J, Sasser LE, Fergus TJ, Ouma GS, Ouma SG, Beck AA, … -
Fishing for Answers in Human Mycobacterial Infections.
Immunity 2017 Bolz M, Ernst JD -
"The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report.
Vaccine 2017 Boggiano C, Eichelberg K, Ramachandra L, Shea J, Ramakrishnan L, Behar S, Ernst JD, Porcelli SA, Maeurer M, Kornfeld H -
Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 100 Luo infants from the Boro area of Nyanza Province, Kenya.
Human immunology 2017 Arlehamn CS, Copin R, Leary S, Mack SJ, Phillips E, Mallal S, Sette A, Blatner G, Siefers H, Ernst JD, TBRU-ASTRa Study Team -
Antigenic Variation and Immune Escape in the MTBC.
Advances in experimental medicine and biology 2017 Ernst JD -
Within Host Evolution Selects for a Dominant Genotype of Mycobacterium tuberculosis while T Cells Increase Pathogen Genetic Diversity.
PLoS pathogens 2016 Copin R, Wang X, Louie E, Escuyer V, Coscolla M, Gagneux S, Palmer GH, Ernst JD -
Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4+ T-cell activation.
Nature microbiology 2016 Portal-Celhay C, Tufariello JM, Srivastava S, Zahra A, Klevorn T, Grace PS, Mehra A, Park HS, Ernst JD, Jacobs WR, Philips JA -
Type I Interferon is Pathogenic During Chronic Mycobacterium africanum Infection.
The Journal of infectious diseases 2016 Wiens KE, Ernst JD -
The Challenge of Latent TB Infection.
JAMA 2016 Blumberg HM, Ernst JD -
The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent.
PLoS pathogens 2016 Wiens KE, Ernst JD -
A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans.
PLoS pathogens 2016 Lindestam Arlehamn CS, McKinney DM, Carpenter C, Paul S, Rozot V, Makgotlho E, Gregg Y, van Rooyen M, Ernst JD, Hatherill M, Hanekom WA, Peters B, Scriba TJ, Sette A -
Antigen Export Reduces Antigen Presentation and Limits T Cell Control of M. tuberculosis.
Cell host & microbe 2016 Srivastava S, Grace PS, Ernst JD -
Correction: LprG-Mediated Surface Expression of Lipoarabinomannan Is Essential for Virulence of Mycobacterium tuberculosis.
PLoS pathogens 2015 Gaur RL, Ren K, Blumenthal A, Bhamidi S, Gibbs S, Jackson M, Zare RN, Ehrt S, Ernst JD, Banaei N -
Suboptimal Antigen Presentation Contributes to Virulence of Mycobacterium tuberculosis In Vivo.
Journal of immunology (Baltimore, Md. : 1950) 2015 Grace PS, Ernst JD -
M. tuberculosis T Cell Epitope Analysis Reveals Paucity of Antigenic Variation and Identifies Rare Variable TB Antigens.
Cell host & microbe 2015 Coscolla M, Copin R, Sutherland J, Gehre F, de Jong B, Owolabi O, Mbayo G, Giardina F, Ernst JD, Gagneux S -
STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection.
The Journal of clinical investigation 2015 Desvignes L, Weidinger C, Shaw P, Vaeth M, Ribierre T, Liu M, Fergus T, Kozhaya L, McVoy L, Unutmaz D, Ernst JD, Feske S -
In vivo biosynthesis of terpene nucleosides provides unique chemical markers of Mycobacterium tuberculosis infection.
Chemistry & biology 2015 Young DC, Layre E, Pan SJ, Tapley A, Adamson J, Seshadri C, Wu Z, Buter J, Minnaard AJ, Coscolla M, Gagneux S, Copin R, Ernst JD, Bishai WR, Snider BB, Moody DB -
Beyond macrophages: the diversity of mononuclear cells in tuberculosis.
Immunological reviews 2014 Srivastava S, Ernst JD, Desvignes L -
LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis.
PLoS pathogens 2014 Gaur RL, Ren K, Blumenthal A, Bhamidi S, González-Nilo FD, Gibbs S, Jackson M, Zare RN, Ehrt S, Ernst JD, Banaei N -
Impact of in vitro evolution on antigenic diversity of Mycobacterium bovis bacillus Calmette-Guerin (BCG).
Vaccine 2014 Copin R, Coscollá M, Efstathiadis E, Gagneux S, Ernst JD -
Cell-to-cell transfer of M. tuberculosis antigens optimizes CD4 T cell priming.
Cell host & microbe 2014 Srivastava S, Ernst JD -
Sequence diversity in the pe_pgrs genes of Mycobacterium tuberculosis is independent of human T cell recognition.
mBio 2014 Copin R, Coscollá M, Seiffert SN, Bothamley G, Sutherland J, Mbayo G, Gagneux S, Ernst JD -
Equivalent T cell epitope promiscuity in ecologically diverse human pathogens.
PloS one 2013 Wiens KE, Swaminathan H, Copin R, Lun DS, Ernst JD -
Cutting edge: Direct recognition of infected cells by CD4 T cells is required for control of intracellular Mycobacterium tuberculosis in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2013 Srivastava S, Ernst JD -
Taking sides: interferons in leprosy.
Cell host & microbe 2013 Desvignes LP, Ernst JD -
Variation of Mycobacterium tuberculosis antigen-specific IFN-γ and IL-17 responses in healthy tuberculin skin test (TST)-positive human subjects.
PloS one 2012 Fan L, Xiao HP, Hu ZY, Ernst JD -
CD4+ T cell-dependent IFN-γ production by CD8+ effector T cells in Mycobacterium tuberculosis infection.
Journal of immunology (Baltimore, Md. : 1950) 2012 Bold TD, Ernst JD -
The immunological life cycle of tuberculosis.
Nature reviews. Immunology 2012 Ernst JD -
Meeting report: The International Conference on Human Immunity to Tuberculosis.
Tuberculosis (Edinburgh, Scotland) 2012 Ernst JD, Hanekom W, Hawn T, Kampmann B, Rengarajan J -
Dynamic roles of type I and type II IFNs in early infection with Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 2012 Desvignes L, Wolf AJ, Ernst JD -
Impaired fitness of Mycobacterium africanum despite secretion of ESAT-6.
The Journal of infectious diseases 2012 Bold TD, Davis DC, Penberthy KK, Cox LM, Ernst JD, de Jong BC -
Mycobacterium tuberculosis inhibits neutrophil apoptosis, leading to delayed activation of naive CD4 T cells.
Cell host & microbe 2012 Blomgran R, Desvignes L, Briken V, Ernst JD -
Tuberculosis pathogenesis and immunity.
Annual review of pathology 2011 Philips JA, Ernst JD -
Suboptimal activation of antigen-specific CD4+ effector cells enables persistence of M. tuberculosis in vivo.
PLoS pathogens 2011 Bold TD, Banaei N, Wolf AJ, Ernst JD -
Lung neutrophils facilitate activation of naive antigen-specific CD4+ T cells during Mycobacterium tuberculosis infection.
Journal of immunology (Baltimore, Md. : 1950) 2011 Blomgran R, Ernst JD -
Directly observing therapy: a new view of drug tolerance in tuberculosis.
Cell 2011 Philips JA, Ernst JD -
HIV and tuberculosis: a deadly human syndemic.
Clinical microbiology reviews 2011 Kwan CK, Ernst JD -
Initiation and regulation of T-cell responses in tuberculosis.
Mucosal immunology 2011 Urdahl KB, Shafiani S, Ernst JD -
Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved.
Nature genetics 2010 Comas I, Chakravartti J, Small PM, Galagan J, Niemann S, Kremer K, Ernst JD, Gagneux S -
Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis.
Immunity 2009 Desvignes L, Ernst JD -
Ectopic activation of Mycobacterium tuberculosis-specific CD4+ T cells in lungs of CCR7-/- mice.
Journal of immunology (Baltimore, Md. : 1950) 2009 Olmos S, Stukes S, Ernst JD -
TLR2-dependent inhibition of macrophage responses to IFN-gamma is mediated by distinct, gene-specific mechanisms.
PloS one 2009 Benson SA, Ernst JD -
Lipoprotein processing is essential for resistance of Mycobacterium tuberculosis to malachite green.
Antimicrobial agents and chemotherapy 2009 Banaei N, Kincaid EZ, Lin SY, Desmond E, Jacobs WR, Ernst JD -
Anti-TNF immunotherapy and tuberculosis reactivation: another mechanism revealed.
The Journal of clinical investigation 2009 Miller EA, Ernst JD -
RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins.
Cell host & microbe 2009 Blumenthal A, Kobayashi T, Pierini LM, Banaei N, Ernst JD, Miyake K, Ehrt S -
Who benefits from granulomas, mycobacteria or host?
Cell 2009 Bold TD, Ernst JD -
Illuminating the black box of TNF action in tuberculous granulomas.
Immunity 2008 Miller EA, Ernst JD -
CO-opting the host HO-1 pathway in tuberculosis and malaria.
Cell host & microbe 2008 Sinnis P, Ernst JD -
Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs.
The Journal of experimental medicine 2007 Wolf AJ, Desvignes L, Linas B, Banaiee N, Tamura T, Takatsu K, Ernst JD -
Meeting Report: NIH Workshop on the Tuberculosis Immune Epitope Database.
Tuberculosis (Edinburgh, Scotland) 2007 Ernst JD, Lewinsohn DM, Behar S, Blythe M, Schlesinger LS, Kornfeld H, Sette A -
An analysis of the epitope knowledge related to Mycobacteria.
Immunome research 2007 Blythe MJ, Zhang Q, Vaughan K, de Castro R, Salimi N, Bui HH, Lewinsohn DM, Ernst JD, Peters B, Sette A -
Codominance of TLR2-dependent and TLR2-independent modulation of MHC class II in Mycobacterium tuberculosis infection in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2007 Kincaid EZ, Wolf AJ, Desvignes L, Mahapatra S, Crick DC, Brennan PJ, Pavelka MS, Ernst JD -
Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2007 Wolf AJ, Linas B, Trevejo-Nuñez GJ, Kincaid E, Tamura T, Takatsu K, Ernst JD -
Genomics and the evolution, pathogenesis, and diagnosis of tuberculosis.
The Journal of clinical investigation 2007 Ernst JD, Trevejo-Nuñez G, Banaiee N -
LspA-independent action of globomycin on Mycobacterium tuberculosis.
The Journal of antimicrobial chemotherapy 2007 Banaiee N, Jacobs WR, Ernst JD -
Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages.
Infection and immunity 2006 Banaiee N, Jacobs WR, Ernst JD -
Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2.
Journal of immunology (Baltimore, Md. : 1950) 2006 Banaiee N, Kincaid EZ, Buchwald U, Jacobs WR, Ernst JD -
GTP-dependent secretion from neutrophils is regulated by Cdk5.
The Journal of biological chemistry 2004 Rosales JL, Ernst JD, Hallows J, Lee KY -
CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 2004 Peters W, Cyster JG, Mack M, Schlöndorff D, Wolf AJ, Ernst JD, Charo IF -
Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 2004 Fortune SM, Solache A, Jaeger A, Hill PJ, Belisle JT, Bloom BR, Rubin EJ, Ernst JD -
Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 2003 Nagabhushanam V, Solache A, Ting LM, Escaron CJ, Zhang JY, Ernst JD -
Mycobacterium tuberculosis exerts gene-selective inhibition of transcriptional responses to IFN-gamma without inhibiting STAT1 function.
Journal of immunology (Baltimore, Md. : 1950) 2003 Kincaid EZ, Ernst JD -
Mechanisms of cell recruitment in the immune response to Mycobacterium tuberculosis.
Microbes and infection 2003 Peters W, Ernst JD -
Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii.
The Journal of biological chemistry 2001 Sonda S, Ting LM, Novak S, Kim K, Maher JJ, Farese RV, Ernst JD -
Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 2001 Peters W, Scott HM, Chambers HF, Flynn JL, Charo IF, Ernst JD -
Bacterial inhibition of phagocytosis.
Cellular microbiology 2000 Ernst JD -
GTP-dependent permeabilized neutrophil secretion requires a freely diffusible cytosolic protein.
Journal of cellular biochemistry 2000 Rosales JL, Ernst JD -
Phagocytosis of crocidolite asbestos induces oxidative stress, DNA damage, and apoptosis in mesothelial cells.
American journal of respiratory cell and molecular biology 2000 Liu W, Ernst JD, Broaddus VC -
Immune responses in tuberculosis.
Current opinion in immunology 2000 Flynn JL, Ernst JD -
Toward the development of antibacterial vaccines: report of a symposium and workshop. Organizing Committee.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1999 Ernst JD -
Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1.
Journal of immunology (Baltimore, Md. : 1950) 1999 Ting LM, Kim AC, Cattamanchi A, Ernst JD -
Editorial response: variation in clinical and immune responses to bacille Calmette-Guérin--implications for an improved tuberculosis vaccine.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1999 Ernst JD -
Preparation and characterization of an endogenously fluorescent annexin for detection of apoptotic cells.
Analytical biochemistry 1998 Ernst JD, Yang L, Rosales JL, Broaddus VC -
Roles of calcium and annexins in phagocytosis and elimination of an attenuated strain of Mycobacterium tuberculosis in human neutrophils.
Microbial pathogenesis 1998 Majeed M, Perskvist N, Ernst JD, Orselius K, Stendahl O -
Macrophage receptors for Mycobacterium tuberculosis.
Infection and immunity 1998 Ernst JD -
Calcium-dependent neutrophil secretion: characterization and regulation by annexins.
Journal of immunology (Baltimore, Md. : 1950) 1997 Rosales JL, Ernst JD -
Role of annexins in endocytosis of antigens in immature human dendritic cells.
Immunology 1997 Larsson M, Majeed M, Ernst JD, Magnusson KE, Stendahl O, Forsum U -
Crocidolite asbestos induces apoptosis of pleural mesothelial cells: role of reactive oxygen species and poly(ADP-ribosyl) polymerase.
Environmental health perspectives 1997 Broaddus VC, Yang L, Scavo LM, Ernst JD, Boylan AM -
Transfer of phagocytosed particles to the parasitophorous vacuole of Leishmania mexicana is a transient phenomenon preceding the acquisition of annexin I by the phagosome.
Journal of cell science 1997 Collins HL, Schaible UE, Ernst JD, Russell DG -
Selective receptor blockade during phagocytosis does not alter the survival and growth of Mycobacterium tuberculosis in human macrophages.
American journal of respiratory cell and molecular biology 1996 Zimmerli S, Edwards S, Ernst JD -
Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species.
The Journal of clinical investigation 1996 Broaddus VC, Yang L, Scavo LM, Ernst JD, Boylan AM -
The (alpha2-->8)-linked polysialic acid capsule of group B Neisseria meningitidis modifies multiple steps during interaction with human macrophages.
Infection and immunity 1996 Read RC, Zimmerli S, Broaddus C, Sanan DA, Stephens DS, Ernst JD -
Detection of altered membrane phospholipid asymmetry in subpopulations of human red blood cells using fluorescently labeled annexin V.
Blood 1996 Kuypers FA, Lewis RA, Hua M, Schott MA, Discher D, Ernst JD, Lubin BH -
Phagosome-lysosome fusion is a calcium-independent event in macrophages.
The Journal of cell biology 1996 Zimmerli S, Majeed M, Gustavsson M, Stendahl O, Sanan DA, Ernst JD -
Mobilization of annexin V during the uptake of DNP-albumin by human dendritic cells.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1995 Larsson M, Majeed M, Stendahl O, Magnusson KE, Ernst JD, Forsum U -
A fluorometric assay for the quantification of RNA in solution with nanogram sensitivity.
Analytical biochemistry 1995 Schmidt DM, Ernst JD -
Calcium signalling initiated by CR1 (CD35) crosslinking is mediated by phagocyte Fc gamma receptors in cis.
Biochemical and biophysical research communications 1995 Ernst JD, Rosales JL, Zimmerli S -
Annexin expression in human dendritic cells.
Advances in experimental medicine and biology 1995 Larsson M, Majeed M, Stendahl O, Magnusson KE, Ernst JD, Forsum U -
Selective translocation of annexins III, IV, and V during intracellular redistribution of Chlamydia trachomatis serovar L2 in HeLa and McCoy cells.
Annals of the New York Academy of Sciences 1994 Majeed M, Ernst JD, Magnusson KE, Kihlström E, Stendahl O -
Annexins possess functionally distinguishable Ca2+ and phospholipid binding domains.
Biochemical and biophysical research communications 1994 Ernst JD, Mall A, Chew G -
Selective translocation of annexins during intracellular redistribution of Chlamydia trachomatis in HeLa and McCoy cells.
Infection and immunity 1994 Majeed M, Ernst JD, Magnusson KE, Kihlström E, Stendahl O -
Epitope mapping of annexin I: antibodies that compete with phospholipids and calcium recognize amino acids 42-99.
The Biochemical journal 1993 Ernst JD -
Annexin III translocates to the periphagosomal region when neutrophils ingest opsonized yeast.
Journal of immunology (Baltimore, Md. : 1950) 1991 Ernst JD -
Identification of a domain that mediates vesicle aggregation reveals functional diversity of annexin repeats.
The Journal of biological chemistry 1991 Ernst JD, Hoye E, Blackwood RA, Mok TL -
Purification and characterization of an abundant cytosolic protein from human neutrophils that promotes Ca2(+)-dependent aggregation of isolated specific granules.
The Journal of clinical investigation 1990 Ernst JD, Hoye E, Blackwood RA, Jaye D -
Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins.
The Biochemical journal 1990 Blackwood RA, Ernst JD -
Use of a novel strategy for the preparation and characterization of an antipeptide antibody capable of recognizing members of the annexin family.
Biochemical and biophysical research communications 1989 Ernst JD, Hoye E, Blackwood RA -
Synexin-like proteins from human polymorphonuclear leukocytes. Identification and characterization of granule-aggregating and membrane-fusing activities.
The Journal of biological chemistry 1987 Meers P, Ernst JD, Düzgünes N, Hong KL, Fedor J, Goldstein IM, Papahadjopoulos D -
Human polymorphonuclear leukocytes contain synexin, a calcium-binding protein that mediates membrane fusion.
Transactions of the Association of American Physicians 1986 Ernst JD, Meers P, Hong K, Duzgunes N, Papahadjopoulos D, Goldstein IM -
Complement (C5)-derived chemotactic activity accounts for accumulation of polymorphonuclear leukocytes in cerebrospinal fluid of rabbits with pneumococcal meningitis.
Infection and immunity 1984 Ernst JD, Hartiala KT, Goldstein IM, Sande MA -
Correlation of in vitro time-kill curves and kinetics of bacterial killing in cerebrospinal fluid during ceftriaxone therapy of experimental Escherichia coli meningitis.
Antimicrobial agents and chemotherapy 1983 Decazes JM, Ernst JD, Sande MA -
Combination antifungal chemotherapy for experimental disseminated candidiasis: lack of correlation between in vitro and in vivo observations with amphotericin B and rifampin.
Reviews of infectious diseases 1983 Ernst JD, Rusnak M, Sande MA -
Experimental pneumococcal meningitis: role of leukocytes in pathogenesis.
Infection and immunity 1983 Ernst JD, Decazes JM, Sande MA -
Inhibition of isolation of Escherichia coli in blood cultures by trimethoprim-sulfamethoxazole.
The Journal of infectious diseases 1983 Hackbarth CJ, Ernst JD, Sande MA -
Antibiotic combinations in experimental infections in animals.
Reviews of infectious diseases 1982 Ernst JD, Sande MA