Joe Wiemels, PhD
Professor
Epidemiology & Biostatistics
School of Medicine

Large population-based studies of human cancer in the San Francisco Bay Area and State of California form a basis for examining the origin of these cancers, with a focus on future prevention. This type of research is highly collaborative, and Dr. Wiemels works with several epidemiologists, geneticists, clinicians, biologists, and statisticians.

• Early-life tobacco exposure is causally implicated in aberrant RAG-mediated recombination in childhood acute lymphoblastic leukemia.
  Leukemia 2024 Liu T, Xu K, Pardeshi A, Myint SS, Kang AY, Morimoto LM, Lieber MR, Wiemels JL, Kogan SC, Metayer C, de Smith AJ
• Folate Metabolism and Risk of Childhood Acute Lymphoblastic Leukemia: A Genetic Pathway Analysis from the Childhood Cancer and Leukemia International Consortium.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2024 Metayer C, Spector LG, Scheurer ME, Jeon S, Scott RJ, Takagi M, Clavel J, Manabe A, Ma X, Hailu EM, Lupo PJ, Urayama KY, Bonaventure A, Kato M, Meirhaeghe A, Chiang CWK, Morimoto LM, Wiemels JL
• Evaluation of the genetic basis of familial-associated early-onset hematologic cancers in an ancestral/ethnically diverse population.
  Haematologica 2024 Feng Q, Xu K, Shah M, Li S, Leavitt AD, Godley LA, De Smith AJ, Wiemels JL
• High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study.
  The Lancet. Planetary health 2024 Rogne T, Wang R, Wang P, Deziel NC, Metayer C, Wiemels JL, Chen K, Warren JL, Ma X
• Early-life tobacco exposure is causally implicated in aberrant RAG-mediated recombination in childhood acute lymphoblastic leukemia.
  Research square 2024 de Smith A, Liu T, Xu K, Pardeshi A, Myint SS, Kang A, Morimoto L, Lieber M, Wiemels J, Kogan S, Metayer C
• Genetic variation near GRB10 associated with bone growth and osteosarcoma risk in canine and human populations.
  Cancer epidemiology 2024 Lucas SE, Yang T, Wimberly CE, Parmar KV, Hansen HM, de Smith AJ, Morimoto LM, Metayer C, Ostrom QT, Eward WC, Graves LA, Wagner LM, Wiemels JL, Spector LG, Walsh KM
• Genome-wide assessment of genetic risk loci for childhood acute lymphoblastic leukemia in Japanese patients.
  Haematologica 2024 Hangai M, Kawaguchi T, Takagi M, Matsuo K, Jeon S, Chiang CWK, Dewan AT, De Smith AJ, Imamura T, Okamoto Y, Saito AM, Deguchi T, Kubo M, Tanaka Y, Ayukawa Y, Hori T, Ohki K, Kiyokawa N, Inukai T, …
• A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children.
  Cell genomics 2024 de Smith AJ, Wahlster L, Jeon S, Kachuri L, Black S, Langie J, Cato LD, Nakatsuka N, Chan TF, Xia G, Mazumder S, Yang W, Gazal S, Eng C, Hu D, Burchard EG, Ziv E, Metayer C, Mancuso N, Yang JJ, Ma X, …
• Maternal Prenatal Use of Alcohol, Tobacco, and Illicit Drugs and Associations with Childhood Cancer Subtypes.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2024 Wimberly CE, Gulrajani NB, Russ JB, Landi D, Wiemels JL, Towry L, Wiencke JK, Walsh KM
• Effect of parental adverse childhood experiences on intergenerational DNA methylation signatures from peripheral blood mononuclear cells and buccal mucosa.
  Translational psychiatry 2024 Mohazzab-Hosseinian S, Garcia E, Wiemels J, Marconett C, Corona K, Howe CG, Foley H, Farzan SF, Bastain TM, Breton CV
• A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation.
  Communications biology 2024 Li S, Spitz N, Ghantous A, Abrishamcar S, Reimann B, Marques I, Silver MJ, Aguilar-Lacasaña S, Kitaba N, Rezwan FI, Röder S, Sirignano L, Tuhkanen J, Mancano G, Sharp GC, Metayer C, Morimoto L, Stein …
• Backtracking to the future: unraveling the origins of childhood leukemia.
  Leukemia 2023 de Smith AJ, Wiemels JL, Mead AJ, Roberts I, Roy A, Spector LG
• Gene-Environment Analyses Reveal Novel Genetic Candidates with Prenatal Tobacco Exposure in Relation to Risk for Childhood Acute Lymphoblastic Leukemia.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2023 Zhong C, Li S, Arroyo K, Morimoto LM, de Smith AJ, Metayer C, Ma X, Kogan SC, Gauderman WJ, Wiemels JL
• Impact of pinworm infection on the development of murine B-cell leukemia/lymphoma in the presence and absence of ETV6::RUNX1.
  Haematologica 2023 Fitch BA, Situ J, Wiemels JL, Kogan SC, Zhou M
• Evaluating genomic polygenic risk scores for childhood acute lymphoblastic leukemia in Latinos.
  HGG advances 2023 Jeon S, Lo YC, Morimoto LM, Metayer C, Ma X, Wiemels JL, de Smith AJ, Chiang CWK
• Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude.
  Clinical epigenetics 2023 Kadalayil L, Alam MZ, White CH, Ghantous A, Walton E, Gruzieva O, Merid SK, Kumar A, Roy RP, Solomon O, Huen K, Eskenazi B, Rzehak P, Grote V, Langhendries JP, Verduci E, Ferre N, Gruszfeld D, Gao L, …
• Multi-ancestry genome-wide association study of 4069 children with glioma identifies 9p21.3 risk locus.
  Neuro-oncology 2023 Foss-Skiftesvik J, Li S, Rosenbaum A, Hagen CM, Stoltze UK, Ljungqvist S, Hjalmars U, Schmiegelow K, Morimoto L, de Smith AJ, Mathiasen R, Metayer C, Hougaard D, Melin B, Walsh KM, Bybjerg-Grauholm J,…
• Association between county-level socioeconomic status and the incidence of and surgical treatment for pituitary adenoma.
  Journal of neurosurgery 2023 Cote DJ, Kruchko C, Barnholtz-Sloan JS, Zada G, Wiemels JL, Ostrom QT
• Effect of Parental Adverse Childhood Experiences on Intergenerational DNA Methylation Signatures.
  Research square 2023 Mohazzab-Hosseinian S, Garcia E, Wiemels J, Marconett C, Corona K, Howe C, Foley H, Lerner D, Lurvey N, Farzan S, Bastain T, Breton C
• Birth characteristics and risk of Ewing sarcoma.
  Cancer causes & control : CCC 2023 Wiemels JL, Wang R, Feng Q, Yee AC, Morimoto LM, Metayer C, Ma X
• Mendelian randomization study of birthweight, gestational age, and risk of childhood acute lymphoblastic leukemia.
  American journal of obstetrics & gynecology MFM 2023 Rogne T, DeWan AT, Metayer C, Wiemels JL, Ma X
• Evaluating Genomic Polygenic Risk Scores for Childhood Acute Lymphoblastic Leukemia in Latinos.
  medRxiv : the preprint server for health sciences 2023 Jeon S, Lo YC, Morimoto LM, Metayer C, Ma X, Wiemels JL, de Smith AJ, Chiang CWK
• Antibodies to varicella-zoster virus and three other herpesviruses and survival in adults with glioma.
  Neuro-oncology 2023 Guerra G, McCoy L, Hansen HM, Rice T, Molinaro AM, Wiemels JL, Wiencke JK, Wrensch M, Francis SS
• Association between birth characteristics and incidence of pituitary adenoma and craniopharyngioma: a registry-based study in California, 2001-2015.
  Cancer causes & control : CCC 2023 Cote DJ, Wang R, Morimoto LM, Metayer C, Zada G, Wiemels JL, Ma X
• High Ambient Temperature in Pregnancy and Risk of Childhood Acute Lymphoblastic Leukemia.
  medRxiv : the preprint server for health sciences 2023 Rogne T, Wang R, Wang P, Deziel NC, Metayer C, Wiemels JL, Chen K, Warren JL, Ma X
• Infections and Acute Lymphoblastic Leukemia: Is the Sum Worth More than the Parts? Evidence from Birth Characteristics.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2023 Wiemels JL, Gallant RE
• One-Carbon (Folate) Metabolism Pathway at Birth and Risk of Childhood Acute Lymphoblastic Leukemia: A Biomarker Study in Newborns.
  Cancers 2023 Metayer C, Imani P, Dudoit S, Morimoto L, Ma X, Wiemels JL, Petrick LM
• Evaluation of Maternal Infection During Pregnancy and Childhood Leukemia Among Offspring in Denmark.
  JAMA network open 2023 He JR, Yu Y, Fang F, Gissler M, Magnus P, László KD, Ward MH, Paltiel O, Tikellis G, Maule MM, Qiu X, Du J, Valdimarsdóttir UA, Rahimi K, Wiemels JL, Linet MS, Hirst JE, Li J, Dwyer T
• Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control.
  Genome biology 2023 Gunasekara CJ, MacKay H, Scott CA, Li S, Laritsky E, Baker MS, Grimm SL, Jun G, Li Y, Chen R, Wiemels JL, Coarfa C, Waterland RA
• Outdoor artificial light at night, air pollution, and risk of childhood acute lymphoblastic leukemia in the California Linkage Study of Early-Onset Cancers.
  Scientific reports 2023 Zhong C, Wang R, Morimoto LM, Longcore T, Franklin M, Rogne T, Metayer C, Wiemels JL, Ma X
• Does Cytomegalovirus Play a Role in Pediatric Lymphoblastic Leukemogenesis?
  JAMA network open 2023 Wiemels JL
• Meta-Analysis of DNA Methylation Datasets Shows Aberrant DNA Methylation of Thyroid Development or Function Genes in Down Syndrome.
  Thyroid : official journal of the American Thyroid Association 2022 Lauffer P, Zwaveling-Soonawala N, Li S, Bacalini MG, Naumova OY, Wiemels J, Boelen A, Henneman P, de Smith AJ, van Trotsenburg ASP
• Periconceptional folate intake influences DNA methylation at birth based on dietary source in an analysis of pediatric acute lymphoblastic leukemia cases and controls.
  The American journal of clinical nutrition 2022 Nickels EM, Li S, Morimoto L, Kang AY, de Smith AJ, Metayer C, Wiemels JL
• Incorporation of DNA methylation quantitative trait loci (mQTLs) in epigenome-wide association analysis: application to birthweight effects in neonatal whole blood.
  Clinical epigenetics 2022 Li S, Mancuso N, Metayer C, Ma X, de Smith AJ, Wiemels JL
• Birth characteristics and risk of meningioma in a population-based study in California.
  Neuro-oncology advances 2022 Cote DJ, Wang R, Morimoto LM, Metayer C, Stempel J, Zada G, Ma X, Wiemels JL
• Investigating DNA methylation as a mediator of genetic risk in childhood acute lymphoblastic leukemia.
  Human molecular genetics 2022 Xu K, Li S, Pandey P, Kang AY, Morimoto LM, Mancuso N, Ma X, Metayer C, Wiemels JL, de Smith AJ
• DNA methylation at birth in monozygotic twins discordant for pediatric acute lymphoblastic leukemia.
  Nature communications 2022 Nickels EM, Li S, Myint SS, Arroyo K, Feng Q, Siegmund KD, de Smith AJ, Wiemels JL
• Associations between early-life and in utero infections and cytomegalovirus-positive acute lymphoblastic leukemia in children.
  International journal of cancer 2022 Gallant RE, Arroyo K, Metayer C, Kang AY, de Smith AJ, Wiemels JL
• Localized variation in ancestral admixture identifies pilocytic astrocytoma risk loci among Latino children.
  PLoS genetics 2022 Li S, Chiang CWK, Myint SS, Arroyo K, Chan TF, Morimoto L, Metayer C, de Smith AJ, Walsh KM, Wiemels JL
• Hispanic Ethnicity Differences in Birth Characteristics, Maternal Birthplace, and Risk of Early-Onset Hodgkin Lymphoma: A Population-Based Case-Control Study.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2022 Graham C, Metayer C, Morimoto LM, Wiemels JL, Siddique A, Di M, Rodwin RL, Kadan-Lottick NS, Ma X, Wang R
• Cytomegalovirus proteins, maternal pregnancy cytokines, and their impact on neonatal immune cytokine profiles and acute lymphoblastic leukemogenesis in children.
  Haematologica 2022 Wiemels JL, Wang R, Zhou M, Hansen H, Gallant R, Jung J, Mancuso N, De Smith AJ, Metayer C, Kogan SC, Ma X
• Epigenome-wide association study of acute lymphoblastic leukemia in children with Down syndrome.
  Blood advances 2022 Li S, Sok P, Xu K, Muskens IS, Elliott N, Myint SS, Pandey P, Hansen HM, Morimoto LM, Kang AY, Metayer C, Ma X, Mueller BA, Roy A, Roberts I, Rabin KR, Brown AL, Lupo PJ, Wiemels JL, de Smith AJ
• Interaction between maternal killer immunoglobulin-like receptors and offspring HLAs and susceptibility of childhood ALL.
  Blood advances 2022 Feng Q, Zhou M, Li S, Morimoto L, Hansen H, Myint SS, Wang R, Metayer C, Kang A, Fear AL, Pappas D, Erlich H, Hollenbach JA, Mancuso N, Trachtenberg E, de Smith AJ, Ma X, Wiemels JL
• Common maternal infections during pregnancy and childhood leukaemia in the offspring: findings from six international birth cohorts.
  International journal of epidemiology 2022 He JR, Hirst JE, Tikellis G, Phillips GS, Ramakrishnan R, Paltiel O, Ponsonby AL, Klebanoff M, Olsen J, Murphy MFG, Håberg SE, Lemeshow S, F Olsen S, Qiu X, Magnus P, Golding J, Ward MH, Wiemels JL, …
• Correction to: Common maternal infections during pregnancy and childhood leukaemia in the offspring: findings from six international birth cohorts.
  International journal of epidemiology 2022 He JR, Hirst JE, Tikellis G, Phillips GS, Ramakrishnan R, Paltiel O, Ponsonby AL, Klebanoff M, Olsen J, Murphy MFG, Håberg SE, Lemeshow S, F Olsen S, Qiu X, Magnus P, Golding J, Ward MH, Wiemels JL, …
• Accelerated epigenetic aging in newborns with Down syndrome.
  Aging cell 2022 Xu K, Li S, Muskens IS, Elliott N, Myint SS, Pandey P, Hansen HM, Morimoto LM, Kang AY, Ma X, Metayer C, Mueller BA, Roberts I, Walsh KM, Horvath S, Wiemels JL, de Smith AJ
• Epigenetic dysregulation in meningiomas.
  Neuro-oncology advances 2022 Wedemeyer MA, Muskens I, Strickland BA, Aurelio O, Martirosian V, Wiemels JL, Weisenberger DJ, Wang K, Mukerjee D, Rhie SK, Zada G
• Variant to function mapping at single-cell resolution through network propagation.
  Nature biotechnology 2022 Yu F, Cato LD, Weng C, Liggett LA, Jeon S, Xu K, Chiang CWK, Wiemels JL, Weissman JS, de Smith AJ, Sankaran VG
• Pleiotropic MLLT10 variation confers risk of meningioma and estrogen-mediated cancers.
  Neuro-oncology advances 2022 Walsh KM, Zhang C, Calvocoressi L, Hansen HM, Berchuck A, Schildkraut JM, Bondy ML, Wrensch M, Wiemels JL, Claus EB
• Mitochondrial 1555 G>A variant as a potential risk factor for childhood glioblastoma.
  Neuro-oncology advances 2022 Li S, Gai X, Myint SS, Arroyo K, Morimoto L, Metayer C, de Smith AJ, Walsh KM, Wiemels JL
• Clinical characteristics of cytomegalovirus-positive pediatric acute lymphoblastic leukemia at diagnosis.
  American journal of hematology 2022 Gallant RE, Arroyo K, Bracci PM, Li S, Metayer C, Kogan SC, Wendt GA, Francis SS, de Smith AJ, Wiemels JL
• Development of a Droplet Digital™ PCR DNA methylation detection and quantification assay of prenatal tobacco exposure.
  BioTechniques 2022 Arroyo K, Nargizyan A, Andrade FG, Myint SS, Lu S, Pandey P, Yee A, de Smith AJ, Wiemels JL
• Variant to function mapping at single-cell resolution through network propagation.
  bioRxiv : the preprint server for biology 2022 Yu F, Cato LD, Weng C, Liggett LA, Jeon S, Xu K, Chiang CWK, Wiemels JL, Weissman JS, de Smith AJ, Sankaran VG
• Decreased IL-10 accelerates B-cell leukemia/lymphoma in a mouse model of pediatric lymphoid leukemia.
  Blood advances 2022 Fitch BA, Zhou M, Situ J, Surianarayanan S, Reeves MQ, Hermiston ML, Wiemels JL, Kogan SC
• Proximity to endocrine-disrupting pesticides and risk of testicular germ cell tumors (TGCT) among adolescents: A population-based case-control study in California.
  International journal of hygiene and environmental health 2021 Swartz SJ, Morimoto LM, Whitehead TP, DeRouen MC, Ma X, Wang R, Wiemels JL, McGlynn KA, Gunier R, Metayer C
• Genome-wide trans-ethnic meta-analysis identifies novel susceptibility loci for childhood acute lymphoblastic leukemia.
  Leukemia 2021 Jeon S, de Smith AJ, Li S, Chen M, Chan TF, Muskens IS, Morimoto LM, DeWan AT, Mancuso N, Metayer C, Ma X, Wiemels JL, Chiang CWK
• Mode of Delivery, Birth Characteristics, and Early-Onset Non-Hodgkin Lymphoma in a Population-Based Case-Control Study.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2021 Dwyer KE, Wang R, Cozen W, Cartmel B, Wiemels JL, Morimoto LM, Metayer C, Ma X
• Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.
  American journal of human genetics 2021 Kachuri L, Jeon S, DeWan AT, Metayer C, Ma X, Witte JS, Chiang CWK, Wiemels JL, de Smith AJ
• Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination.
  Cell reports 2021 Martirosian V, Deshpande K, Zhou H, Shen K, Smith K, Northcott P, Lin M, Stepanosyan V, Das D, Remsik J, Isakov D, Boire A, De Feyter H, Hurth K, Li S, Wiemels J, Nakamura B, Shao L, Danilov C, Chen T…
• Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination.
  Cell reports 2021 Martirosian V, Deshpande K, Zhou H, Shen K, Smith K, Northcott P, Lin M, Stepanosyan V, Das D, Remsik J, Isakov D, Boire A, De Feyter H, Hurth K, Li S, Wiemels J, Nakamura B, Shao L, Danilov C, Chen T…
• Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites.
  eLife 2021 Feng Q, Nickels E, Muskens IS, de Smith AJ, Gauderman WJ, Yee AC, Ricker C, Mack T, Leavitt AD, Godley LA, Wiemels JL
• Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2021 Whitehead TP, Wiemels JL, Zhou M, Kang AY, McCoy LS, Wang R, Fitch B, Petrick LM, Yano Y, Imani P, Rappaport SM, Dahl GV, Kogan SC, Ma X, Metayer C
• Epigenetic Biomarkers of Prenatal Tobacco Smoke Exposure Are Associated with Gene Deletions in Childhood Acute Lymphoblastic Leukemia.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2021 Xu K, Li S, Whitehead TP, Pandey P, Kang AY, Morimoto LM, Kogan SC, Metayer C, Wiemels JL, de Smith AJ
• In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system.
  Clinical science (London, England : 1979) 2021 Snijders AM, Zhou M, Whitehead TP, Fitch B, Pandey P, Hechmer A, Huang A, Schick SF, de Smith AJ, Olshen AB, Metayer C, Mao JH, Wiemels JL, Kogan SC
• Trends in Acute Lymphoblastic Leukemia Incidence in the United States by Race/Ethnicity From 2000 to 2016.
  American journal of epidemiology 2021 Feng Q, de Smith AJ, Vergara-Lluri M, Muskens IS, McKean-Cowdin R, Kogan S, Brynes R, Wiemels JL
• Pediatric Acute Promyelocytic Leukemia: Epidemiology, Molecular Features, and Importance of GST-Theta 1 in Chemotherapy Response and Outcome.
  Frontiers in oncology 2021 Andrade FG, Feliciano SVM, Sardou-Cezar I, Brisson GD, Dos Santos-Bueno FV, Vianna DT, Marques LVC, Terra-Granado E, Zalcberg I, Santos MO, Costa JT, Noronha EP, Thuler LCS, Wiemels JL, Pombo-de-…
• Low CtBP2 expression is associated with a stem cell-like signature and adverse clinical outcome in childhood B-cell lymphoblastic leukemia.
  Leukemia 2021 Chun S, Kim HY, Kim HJ, Koo HH, Yoo KH, Kim SH, Zhou M, Lee ST, Wiemels JL
• The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.
  Nature communications 2021 Muskens IS, Li S, Jackson T, Elliot N, Hansen HM, Myint SS, Pandey P, Schraw JM, Roy R, Anguiano J, Goudevenou K, Siegmund KD, Lupo PJ, de Bruijn MFTR, Walsh KM, Vyas P, Ma X, Roy A, Roberts I, …
• Adult diffuse glioma GWAS by molecular subtype identifies variants in D2HGDH and FAM20C.
  Neuro-oncology 2020 Eckel-Passow JE, Drucker KL, Kollmeyer TM, Kosel ML, Decker PA, Molinaro AM, Rice T, Praska CE, Clark L, Caron A, Abyzov A, Batzler A, Song JS, Pekmezci M, Hansen HM, McCoy LS, Bracci PM, Wiemels J, …
• European genetic ancestry associated with risk of childhood ependymoma.
  Neuro-oncology 2020 Zhang C, Ostrom QT, Hansen HM, Gonzalez-Maya J, Hu D, Ziv E, Morimoto L, de Smith AJ, Muskens IS, Kline CN, Vaksman Z, Hakonarson H, Diskin SJ, Kruchko C, Barnholtz-Sloan JS, Ramaswamy V, Ali-Osman F,…
• The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome.
  Nature cancer 2020 Duran-Ferrer M, Clot G, Nadeu F, Beekman R, Baumann T, Nordlund J, Marincevic-Zuniga Y, Lönnerholm G, Rivas-Delgado A, Martín S, Ordoñez R, Castellano G, Kulis M, Queirós AC, Lee ST, Wiemels J, Royo R…
• Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma.
  Acta neuropathologica communications 2020 Zhang C, Ostrom QT, Semmes EC, Ramaswamy V, Hansen HM, Morimoto L, de Smith AJ, Pekmezci M, Vaksman Z, Hakonarson H, Diskin SJ, Metayer C, Glioma International Case-Control Study (GICC), Taylor MD, …
• Socioeconomic status and childhood central nervous system tumors in California.
  Cancer causes & control : CCC 2020 Francis SS, Wang R, Enders C, Prado I, Wiemels JL, Ma X, Metayer C
• Birth Characteristics and Risk of Pediatric Thyroid Cancer: A Population-Based Record-Linkage Study in California.
  Thyroid : official journal of the American Thyroid Association 2020 Deziel NC, Zhang Y, Wang R, Wiemels JL, Morimoto L, Clark CJ, Metayer C, Ma X
• History of Early Childhood Infections and Acute Lymphoblastic Leukemia Risk Among Children in a US Integrated Health-Care System.
  American journal of epidemiology 2020 Morimoto LM, Kwan ML, Deosaransingh K, Munneke JR, Kang AY, Quesenberry C, Kogan S, de Smith AJ, Metayer C, Wiemels JL
• Outdoor artificial light at night and risk of non-Hodgkin lymphoma among women in the California Teachers Study cohort.
  Cancer epidemiology 2020 Zhong C, Franklin M, Wiemels J, McKean-Cowdin R, Chung NT, Benbow J, Wang SS, Lacey JV, Longcore T
• Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis.
  Neuro-oncology advances 2020 Muskens IS, Feng Q, Francis SS, Walsh KM, Mckean-Cowdin R, Gauderman WJ, de Smith AJ, Wiemels JL
• Germline cancer predisposition variants and pediatric glioma: a population-based study in California.
  Neuro-oncology 2020 Muskens IS, de Smith AJ, Zhang C, Hansen HM, Morimoto L, Metayer C, Ma X, Walsh KM, Wiemels JL
• Birth Characteristics and Risk of Early-Onset Synovial Sarcoma.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2020 Wiemels JL, Wang R, Feng Q, Clark CJ, Amatruda JF, Rubin E, Yee AC, Morimoto LM, Metayer C, Ma X
• Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age.
  Genome medicine 2020 Merid SK, Novoloaca A, Sharp GC, Küpers LK, Kho AT, Roy R, Gao L, Annesi-Maesano I, Jain P, Plusquin M, Kogevinas M, Allard C, Vehmeijer FO, Kazmi N, Salas LA, Rezwan FI, Zhang H, Sebert S, Czamara D,…
• Spatial-Temporal Cluster Analysis of Childhood Cancer in California.
  Epidemiology (Cambridge, Mass.) 2020 Francis SS, Enders C, Hyde R, Gao X, Wang R, Ma X, Wiemels JL, Selvin S, Metayer C
• Germline variants in predisposition genes in children with Down syndrome and acute lymphoblastic leukemia.
  Blood advances 2020 Winer P, Muskens IS, Walsh KM, Vora A, Moorman AV, Wiemels JL, Roberts I, Roy A, de Smith AJ
• Maternal Infection in Pregnancy and Childhood Leukemia: A Systematic Review and Meta-analysis.
  The Journal of pediatrics 2019 He JR, Ramakrishnan R, Hirst JE, Bonaventure A, Francis SS, Paltiel O, Håberg SE, Lemeshow S, Olsen S, Tikellis G, Magnus P, Murphy MFG, Wiemels JL, Linet MS, Dwyer T
• Germline genetic landscape of pediatric central nervous system tumors.
  Neuro-oncology 2019 Muskens IS, Zhang C, de Smith AJ, Biegel JA, Walsh KM, Wiemels JL
• Brain tumor disparities: From biology to social determinants - The 2019 Brain Tumor Epidemiology Consortium meeting report.
  Clinical neuropathology 2019 Johnson KJ, Bauchet L, Hainfellner JA, Kruchko C, Scheurer ME, Wiemels J, Schwartzbaum J
• Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome.
  Blood 2019 Brown AL, de Smith AJ, Gant VU, Yang W, Scheurer ME, Walsh KM, Chernus JM, Kallsen NA, Peyton SA, Davies GE, Ehli EA, Winick N, Heerema NA, Carroll AJ, Borowitz MJ, Wood BL, Carroll WL, Raetz EA, …
• Immune factors preceding diagnosis of glioma: a Prostate Lung Colorectal Ovarian Cancer Screening Trial nested case-control study.
  Neuro-oncology advances 2019 Muskens IS, Zhou M, Mccoy L, Bracci PM, Hansen HM, Gauderman WJ, Wiencke JK, Wrensch MR, Wiemels JL
• Common genetic variation and risk of osteosarcoma in a multi-ethnic pediatric and adolescent population.
  Bone 2019 Zhang C, Hansen HM, Semmes EC, Gonzalez-Maya J, Morimoto L, Wei Q, Eward WC, DeWitt SB, Hurst JH, Metayer C, de Smith AJ, Wiemels JL, Walsh KM
• Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome.
  Leukemia 2019 de Smith AJ, Walsh KM, Morimoto LM, Francis SS, Hansen HM, Jeon S, Gonseth S, Chen M, Sun H, Luna-Fineman S, Antillón F, Girón V, Kang AY, Smirnov I, Shao X, Whitehead TP, Barcellos LF, Jolly KW, …
• Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children.
  Genes, chromosomes & cancer 2019 de Smith AJ, Lavoie G, Walsh KM, Aujla S, Evans E, Hansen HM, Smirnov I, Kang AY, Zenker M, Ceremsak JJ, Stieglitz E, Muskens IS, Roberts W, McKean-Cowdin R, Metayer C, Roux PP, Wiemels JL
• Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.
  Nature communications 2019 Küpers LK, Monnereau C, Sharp GC, Yousefi P, Salas LA, Ghantous A, Page CM, Reese SE, Wilcox AJ, Czamara D, Starling AP, Novoloaca A, Lent S, Roy R, Hoyo C, Breton CV, Allard C, Just AC, Bakulski KM, …
• Early Infection with Cytomegalovirus and Risk of Childhood Hematologic Malignancies.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2019 Wiemels JL, Talbäck M, Francis S, Feychting M
• Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology.
  Haematologica 2019 Nielsen AB, Zhou M, de Smith AJ, Wang R, McCoy L, Hansen H, Morimoto L, Grønbæk K, Johansen C, Kogan SC, Metayer C, Bracci PM, Ma X, Wiemels JL
• Body mass index, comorbidities, and hormonal factors in relation to meningioma in an ethnically diverse population: the Multiethnic Cohort.
  Neuro-oncology 2019 Muskens IS, Wu AH, Porcel J, Cheng I, Le Marchand L, Wiemels JL, Setiawan VW
• Using germline variants to estimate glioma and subtype risks.
  Neuro-oncology 2019 Eckel-Passow JE, Decker PA, Kosel ML, Kollmeyer TM, Molinaro AM, Rice T, Caron AA, Drucker KL, Praska CE, Pekmezci M, Hansen HM, McCoy LS, Bracci PM, Erickson BJ, Lucchinetti CF, Wiemels JL, Wiencke …
• Epigenomic profiling of newborns with isolated orofacial clefts reveals widespread DNA methylation changes and implicates metastable epiallele regions in disease risk.
  Epigenetics 2019 Gonseth S, Shaw GM, Roy R, Segal MR, Asrani K, Rine J, Wiemels J, Marini NJ
• Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk.
  Journal of neuro-oncology 2019 Muskens IS, Hansen HM, Smirnov IV, Molinaro AM, Bondy ML, Schildkraut JM, Wrensch M, Wiemels JL, Claus EB
• Mendelian randomization provides support for obesity as a risk factor for meningioma.
  Scientific reports 2019 Takahashi H, Cornish AJ, Sud A, Law PJ, Disney-Hogg L, Calvocoressi L, Lu L, Hansen HM, Smirnov I, Walsh KM, Schramm J, Hoffmann P, Nöthen MM, Jöckel KH, Schildkraut JM, Simon M, Bondy M, Wrensch M, …
• Advancing brain tumor epidemiology - multi-level integration and international collaboration: The 2018 Brain Tumor Epidemiology Consortium meeting report.
  Clinical neuropathology 2018 Johnson KJ, Broholm H, Scheurer ME, Lau CC, Hainfellner JA, Wiemels J, Schwartzbaum J
• Genome-wide association analysis identifies a meningioma risk locus at 11p15.5.
  Neuro-oncology 2018 Claus EB, Cornish AJ, Broderick P, Schildkraut JM, Dobbins SE, Holroyd A, Calvocoressi L, Lu L, Hansen HM, Smirnov I, Walsh KM, Schramm J, Hoffmann P, Nöthen MM, Jöckel KH, Swerdlow A, Larsen SB, …
• BMI1 enhancer polymorphism underlies chromosome 10p12.31 association with childhood acute lymphoblastic leukemia.
  International journal of cancer 2018 de Smith AJ, Walsh KM, Francis SS, Zhang C, Hansen HM, Smirnov I, Morimoto L, Whitehead TP, Kang A, Shao X, Barcellos LF, McKean-Cowdin R, Zhang L, Fu C, Wang R, Yu H, Hoh J, Dewan AT, Metayer C, Ma X…
• Genetic determinants of childhood and adult height associated with osteosarcoma risk.
  Cancer 2018 Zhang C, Morimoto LM, de Smith AJ, Hansen HM, Gonzalez-Maya J, Endicott AA, Smirnov IV, Metayer C, Wei Q, Eward WC, Wiemels JL, Walsh KM
• Neonatal Inflammatory Markers Are Associated with Childhood B-cell Precursor Acute Lymphoblastic Leukemia.
  Cancer research 2018 Søegaard SH, Rostgaard K, Skogstrand K, Wiemels JL, Schmiegelow K, Hjalgrim H
• To ERV Is Human: A Phenotype-Wide Scan Linking Polymorphic Human Endogenous Retrovirus-K Insertions to Complex Phenotypes.
  Frontiers in genetics 2018 Wallace AD, Wendt GA, Barcellos LF, de Smith AJ, Walsh KM, Metayer C, Costello JF, Wiemels JL, Francis SS
• Allergies and Childhood Acute Lymphoblastic Leukemia: A Case-Control Study and Meta-analysis.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2018 Wallace AD, Francis SS, Ma X, McKean-Cowdin R, Selvin S, Whitehead TP, Barcellos LF, Kang AY, Morimoto L, Moore TB, Wiemels JL, Metayer C
• Two HLA Class II Gene Variants Are Independently Associated with Pediatric Osteosarcoma Risk.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2018 Zhang C, Wiemels JL, Hansen HM, Gonzalez-Maya J, Endicott AA, de Smith AJ, Smirnov IV, Witte JS, Morimoto LM, Metayer C, Walsh KM
• Herpesvirus Infection in Infants with Gastroschisis.
  Epidemiology (Cambridge, Mass.) 2018 Francis SS, Wiemels JL, Yang W, Shaw GM
• An overview of disparities in childhood cancer: Report on the Inaugural Symposium on Childhood Cancer Health Disparities, Houston, Texas, 2016.
  Pediatric hematology and oncology 2018 Scheurer ME, Lupo PJ, Schüz J, Spector LG, Wiemels JL, Aplenc R, Gramatges MM, Schiffman JD, Pombo-de-Oliveira MS, Yang JJ, Heck JE, Metayer C, Orjuela-Grimm MA, Bona K, Aristizabal P, Austin MT, …
• Genomic characterization of chronic lymphocytic leukemia (CLL) in radiation-exposed Chornobyl cleanup workers.
  Environmental health : a global access science source 2018 Ojha J, Dyagil I, Finch SC, Reiss RF, de Smith AJ, Gonseth S, Zhou M, Hansen HM, Sherborne AL, Nakamura J, Bracci PM, Gudzenko N, Hatch M, Babkina N, Little MP, Chumak VV, Walsh KM, Bazyka D, Wiemels …
• Neonatal Hormone Concentrations and Risk of Testicular Germ Cell Tumors (TGCT).
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2018 Morimoto LM, Zava D, McGlynn KA, Stanczyk FZ, Kang AY, Ma X, Wiemels JL, Metayer C
• Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium.
  International journal of epidemiology 2018 Felix JF, Joubert BR, Baccarelli AA, Sharp GC, Almqvist C, Annesi-Maesano I, Arshad H, Baïz N, Bakermans-Kranenburg MJ, Bakulski KM, Binder EB, Bouchard L, Breton CV, Brunekreef B, Brunst KJ, Burchard…
• GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21.
  Nature communications 2018 Wiemels JL, Walsh KM, de Smith AJ, Metayer C, Gonseth S, Hansen HM, Francis SS, Ojha J, Smirnov I, Barcellos L, Xiao X, Morimoto L, McKean-Cowdin R, Wang R, Yu H, Hoh J, DeWan AT, Ma X
• Brain tumor epidemiology in the era of precision medicine: The 2017 Brain Tumor Epidemiology Consortium meeting report.
  Clinical neuropathology 2017 Johnson KJ, Schwartzbaum J, Kruchko C, Scheurer ME, Lau CC, Woehrer A, Hainfellner JA, Wiemels J
• Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium.
  Human molecular genetics 2017 Sharp GC, Salas LA, Monnereau C, Allard C, Yousefi P, Everson TM, Bohlin J, Xu Z, Huang RC, Reese SE, Xu CJ, Baïz N, Hoyo C, Agha G, Roy R, Holloway JW, Ghantous A, Merid SK, Bakulski KM, Küpers LK, …
• A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology.
  Haematologica 2017 Wallace AD, Francis SS, Shao X, de Smith AJ, Walsh KM, Mckean-Cowdin R, Ma X, Dahl G, Barcellos LF, Wiemels JL, Metayer C
• Parental Age and Risk of Pediatric Cancer in the Offspring: A Population-Based Record-Linkage Study in California.
  American journal of epidemiology 2017 Wang R, Metayer C, Morimoto L, Wiemels JL, Yang J, DeWan AT, Kang A, Ma X
• Quality of life after surgery for intracranial meningioma.
  Cancer 2017 Benz LS, Wrensch MR, Schildkraut JM, Bondy ML, Warren JL, Wiemels JL, Claus EB
• Non-additive and epistatic effects of HLA polymorphisms contributing to risk of adult glioma.
  Journal of neuro-oncology 2017 Zhang C, de Smith AJ, Smirnov IV, Wiencke JK, Wiemels JL, Witte JS, Walsh KM
• Buccal mucosa micronuclei counts in relation to exposure to low dose-rate radiation from the Chornobyl nuclear accident and other medical and occupational radiation exposures.
  Environmental health : a global access science source 2017 Bazyka D, Finch SC, Ilienko IM, Lyaskivska O, Dyagil I, Trotsiuk N, Gudzenko N, Chumak VV, Walsh KM, Wiemels J, Little MP, Zablotska LB
• Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group.
  Environmental health perspectives 2017 Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, …
• Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT.
  Acta neuropathologica 2017 Pekmezci M, Rice T, Molinaro AM, Walsh KM, Decker PA, Hansen H, Sicotte H, Kollmeyer TM, McCoy LS, Sarkar G, Perry A, Giannini C, Tihan T, Berger MS, Wiemels JL, Bracci PM, Eckel-Passow JE, Lachance …
• Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia.
  Cancer research 2017 de Smith AJ, Kaur M, Gonseth S, Endicott A, Selvin S, Zhang L, Roy R, Shao X, Hansen HM, Kang AY, Walsh KM, Dahl GV, McKean-Cowdin R, Metayer C, Wiemels JL
• Immunomethylomic approach to explore the blood neutrophil lymphocyte ratio (NLR) in glioma survival.
  Clinical epigenetics 2017 Wiencke JK, Koestler DC, Salas LA, Wiemels JL, Roy RP, Hansen HM, Rice T, McCoy LS, Bracci PM, Molinaro AM, Kelsey KT, Wrensch MR, Christensen BC
• Cesarean Section and Risk of Childhood Acute Lymphoblastic Leukemia in a Population-Based, Record-Linkage Study in California.
  American journal of epidemiology 2016 Wang R, Wiemels JL, Metayer C, Morimoto L, Francis SS, Kadan-Lottick N, DeWan AT, Zhang Y, Ma X
• In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia.
  Blood 2016 Francis SS, Wallace AD, Wendt GA, Li L, Liu F, Riley LW, Kogan S, Walsh KM, de Smith AJ, Dahl GV, Ma X, Delwart E, Metayer C, Wiemels JL
• Trends in childhood leukemia incidence over two decades from 1992 to 2013.
  International journal of cancer 2016 Barrington-Trimis JL, Cockburn M, Metayer C, Gauderman WJ, Wiemels J, McKean-Cowdin R
• Perinatal factors associated with clinical presentation of osteosarcoma in children and adolescents.
  Pediatric blood & cancer 2016 Endicott AA, Morimoto LM, Kline CN, Wiemels JL, Metayer C, Walsh KM
• Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia.
  Oncotarget 2016 de Smith AJ, Ojha J, Francis SS, Sanders E, Endicott AA, Hansen HM, Smirnov I, Termuhlen AM, Walsh KM, Metayer C, Wiemels JL
• Birth weight and risk of paediatric Hodgkin lymphoma: Findings from a population-based record linkage study in California.
  European journal of cancer (Oxford, England : 1990) 2016 Triebwasser C, Wang R, DeWan AT, Metayer C, Morimoto L, Wiemels JL, Kadan-Lottick N, Ma X
• Childhood Leukemia: A Preventable Disease.
  Pediatrics 2016 Metayer C, Dahl G, Wiemels J, Miller M
• Tobacco Smoke and Ras Mutations Among Latino and Non-Latino Children with Acute Lymphoblastic Leukemia.
  Archives of medical research 2016 Kaur M, de Smith AJ, Selvin S, Zhang L, Cunningham M, Kang MW, Hansen HM, Cooper RM, McKean-Cowdin R, Wiemels JL, Metayer C
• Childhood Leukemia and Primary Prevention.
  Current problems in pediatric and adolescent health care 2016 Whitehead TP, Metayer C, Wiemels JL, Singer AW, Miller MD
• Immune factors and viral interactions in brain cancer etiology and outcomes, The 2016 Brain Tumor Epidemiology Consortium Meeting report.
  Clinical neuropathology 2016 Johnson KJ, Hainfellner JA, Lau CC, Scheurer ME, Woehrer A, Wiemels J
• Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates.
  Epigenetics 2016 Gonseth S, de Smith AJ, Roy R, Zhou M, Lee ST, Shao X, Ohja J, Wrensch MR, Walsh KM, Metayer C, Wiemels JL
• Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome.
  Critical care (London, England) 2016 Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA, NHLBI ARDS Network
• Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2016 Ojha J, Codd V, Nelson CP, Samani NJ, Smirnov IV, Madsen NR, Hansen HM, de Smith AJ, Bracci PM, Wiencke JK, Wrensch MR, Wiemels JL, Walsh KM, ENGAGE Consortium Telomere Group
• Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers.
  Carcinogenesis 2016 Walsh KM, Whitehead TP, de Smith AJ, Smirnov IV, Park M, Endicott AA, Francis SS, Codd V, ENGAGE Consortium Telomere Group, Samani NJ, Metayer C, Wiemels JL
• Pathway Analysis of Genome-wide Association Study in Childhood Leukemia among Hispanics.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2016 Hsu LI, Briggs F, Shao X, Metayer C, Wiemels JL, Chokkalingam AP, Barcellos LF
• Stressful exit from the womb and risk of childhood leukaemia.
  The Lancet. Haematology 2016 Wiemels J, Ma X
• Composition, Assembly, and Trafficking of a Wheat Xylan Synthase Complex.
  Plant physiology 2016 Jiang N, Wiemels RE, Soya A, Whitley R, Held M, Faik A
• Genome-wide Annotation, Identification, and Global Transcriptomic Analysis of Regulatory or Small RNA Gene Expression in Staphylococcus aureus.
  mBio 2016 Carroll RK, Weiss A, Broach WH, Wiemels RE, Mogen AB, Rice KC, Shaw LN
• Evolving evidence on tumor and germline genetic classification of gliomas: implications for etiology and survival studies.
  Clinical neuropathology 2016 Johnson KJ, Scheurer ME, Woehrer A, Wiemels J
• New insights into childhood leukemia etiology.
  European journal of epidemiology 2015 Wiemels J
• Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk.
  Oncotarget 2015 Walsh KM, Codd V, Rice T, Nelson CP, Smirnov IV, McCoy LS, Hansen HM, Elhauge E, Ojha J, Francis SS, Madsen NR, Bracci PM, Pico AR, Molinaro AM, Tihan T, Berger MS, Chang SM, Prados MD, Jenkins RB, …
• Birth weight, fetal growth, and risk of pediatric rhabdomyosarcoma: an updated record linkage study in California.
  Annals of epidemiology 2015 Morimoto LM, McCauley K, Ma X, Wiemels JL, Chokkalingam AP, Metayer C
• Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA.
  PloS one 2015 de Smith AJ, Walsh KM, Hansen HM, Endicott AA, Wiencke JK, Metayer C, Wiemels JL
• A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution.
  Cancer research 2015 Walsh KM, de Smith AJ, Hansen HM, Smirnov IV, Gonseth S, Endicott AA, Xiao J, Rice T, Fu CH, McCoy LS, Lachance DH, Eckel-Passow JE, Wiencke JK, Jenkins RB, Wrensch MR, Ma X, Metayer C, Wiemels JL
• Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites.
  Nucleic acids research 2015 Lee ST, Wiemels JL
• A functional polymorphism in the CEBPE gene promoter influences acute lymphoblastic leukemia risk through interaction with the hematopoietic transcription factor Ikaros.
  Leukemia 2015 Wiemels JL, de Smith AJ, Xiao J, Lee ST, Muench MO, Fomin ME, Zhou M, Hansen HM, Termuhlen A, Metayer C, Walsh KM
• Understanding inherited genetic risk of adult glioma - a review.
  Neuro-oncology practice 2015 Rice T, Lachance DH, Molinaro AM, Eckel-Passow JE, Walsh KM, Barnholtz-Sloan J, Ostrom QT, Francis SS, Wiemels J, Jenkins RB, Wiencke JK, Wrensch MR
• Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors.
  The New England journal of medicine 2015 Eckel-Passow JE, Lachance DH, Molinaro AM, Walsh KM, Decker PA, Sicotte H, Pekmezci M, Rice T, Kosel ML, Smirnov IV, Sarkar G, Caron AA, Kollmeyer TM, Praska CE, Chada AR, Halder C, Hansen HM, McCoy …
• Whole-genome fingerprint of the DNA methylome during human B cell differentiation.
  Nature genetics 2015 Kulis M, Merkel A, Heath S, Queirós AC, Schuyler RP, Castellano G, Beekman R, Raineri E, Esteve A, Clot G, Verdaguer-Dot N, Duran-Ferrer M, Russiñol N, Vilarrasa-Blasi R, Ecker S, Pancaldi V, Rico D, …
• Telomere maintenance and the etiology of adult glioma.
  Neuro-oncology 2015 Walsh KM, Wiencke JK, Lachance DH, Wiemels JL, Molinaro AM, Eckel-Passow JE, Jenkins RB, Wrensch MR
• Rising rates of acute lymphoblastic leukemia in Hispanic children: trends in incidence from 1992 to 2011.
  Blood 2015 Barrington-Trimis JL, Cockburn M, Metayer C, Gauderman WJ, Wiemels J, McKean-Cowdin R
• What causes leukemia?
  Pediatric blood & cancer 2015 Dahl G, Wiemels J
• Excess winter deaths caused by cardiovascular diseases are associated with both mild winter temperature and socio-economic inequalities in the U.S.
  International journal of cardiology 2015 Gonseth S, Nusslé S, Bovet P, Panese F, Wiemels JL
• Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children.
  Cancer causes & control : CCC 2015 Hsu LI, Chokkalingam AP, Briggs FB, Walsh K, Crouse V, Fu C, Metayer C, Wiemels JL, Barcellos LF, Buffler PA
• Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures.
  Nucleic acids research 2015 Lee ST, Muench MO, Fomin ME, Xiao J, Zhou M, de Smith A, Martín-Subero JI, Heath S, Houseman EA, Roy R, Wrensch M, Wiencke J, Metayer C, Wiemels JL
• Serum macrophage-derived chemokine/CCL22 levels are associated with glioma risk, CD4 T cell lymphopenia and survival time.
  International journal of cancer 2015 Zhou M, Bracci PM, McCoy LS, Hsuang G, Wiemels JL, Rice T, Zheng S, Kelsey KT, Wrensch MR, Wiencke JK
• Brain Tumor Epidemiology - A Hub within Multidisciplinary Neuro-oncology. Report on the 15th Brain Tumor Epidemiology Consortium (BTEC) Annual Meeting, Vienna, 2014.
  Clinical neuropathology 2015 Woehrer A, Lau CC, Prayer D, Bauchet L, Rosenfeld M, Capper D, Fisher PG, Kool M, Müller M, Kros JM, Kruchko C, Wiemels J, Wrensch M, Danysh HE, Zouaoui S, Heck JE, Johnson KJ, Qi X, O'Neill BP, Afzal…
• Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes.
  Epigenetics 2015 Gonseth S, Roy R, Houseman EA, de Smith AJ, Zhou M, Lee ST, Nusslé S, Singer AW, Wrensch MR, Metayer C, Wiemels JL
• Survival and low-grade glioma: the emergence of genetic information.
  Neurosurgical focus 2015 Claus EB, Walsh KM, Wiencke JK, Molinaro AM, Wiemels JL, Schildkraut JM, Bondy ML, Berger M, Jenkins R, Wrensch M
• Integrative Bayesian variable selection with gene-based informative priors for genome-wide association studies.
  BMC genetics 2014 Zhang X, Xue F, Liu H, Zhu D, Peng B, Wiemels JL, Yang X
• Global characteristics of childhood acute promyelocytic leukemia.
  Blood reviews 2014 Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
• Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.
  Nature genetics 2014 Walsh KM, Codd V, Smirnov IV, Rice T, Decker PA, Hansen HM, Kollmeyer T, Kosel ML, Molinaro AM, McCoy LS, Bracci PM, Cabriga BS, Pekmezci M, Zheng S, Wiemels JL, Pico AR, Tihan T, Berger MS, Chang SM,…
• Genomic ancestry and somatic alterations correlate with age at diagnosis in Hispanic children with B-cell acute lymphoblastic leukemia.
  American journal of hematology 2014 Walsh KM, de Smith AJ, Welch TC, Smirnov I, Cunningham MJ, Ma X, Chokkalingam AP, Dahl GV, Roberts W, Barcellos LF, Buffler PA, Metayer C, Wiemels JL
• Serum immunoglobulin e and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trial.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2014 Olson SH, Hsu M, Wiemels JL, Bracci PM, Zhou M, Patoka J, Reisacher WR, Wang J, Kurtz RC, Silverman DT, Stolzenberg-Solomon RZ
• Mode of delivery and risk of childhood leukemia.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2014 Francis SS, Selvin S, Metayer C, Wallace AD, Crouse V, Moore TB, Wiemels JL, Buffler PA
• PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia.
  International journal of cancer 2014 Xiao J, Lee ST, Xiao Y, Ma X, Houseman EA, Hsu LI, Roy R, Wrensch M, de Smith AJ, Chokkalingam A, Buffler P, Wiencke JK, Wiemels JL
• The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia.
  Blood 2014 de Smith AJ, Walsh KM, Ladner MB, Zhang S, Xiao C, Cohen F, Moore TB, Chokkalingam AP, Metayer C, Buffler PA, Trachtenberg EA, Wiemels JL
• Direct and indirect targets of the E2A-PBX1 leukemia-specific fusion protein.
  PloS one 2014 Diakos C, Xiao Y, Zheng S, Kager L, Dworzak M, Wiemels JL
• Endogenous and exogenous hormone exposure and the risk of meningioma in men.
  Journal of neurosurgery 2014 Schildkraut JM, Calvocoressi L, Wang F, Wrensch M, Bondy ML, Wiemels JL, Claus EB
• Cancer cluster investigations: review of the past and proposals for the future.
  International journal of environmental research and public health 2014 Goodman M, LaKind JS, Fagliano JA, Lash TL, Wiemels JL, Winn DM, Patel C, Van Eenwyk J, Kohler BA, Schisterman EF, Albert P, Mattison DR
• GATA3 risk alleles are associated with ancestral components in Hispanic children with ALL.
  Blood 2013 Walsh KM, de Smith AJ, Chokkalingam AP, Metayer C, Roberts W, Barcellos LF, Wiemels JL, Buffler PA
• Interaction of allergy history and antibodies to specific varicella-zoster virus proteins on glioma risk.
  International journal of cancer 2013 Lee ST, Bracci P, Zhou M, Rice T, Wiencke J, Wrensch M, Wiemels J
• SNP association mapping across the extended major histocompatibility complex and risk of B-cell precursor acute lymphoblastic leukemia in children.
  PloS one 2013 Urayama KY, Chokkalingam AP, Metayer C, Hansen H, May S, Ramsay P, Wiemels JL, Wiencke JK, Trachtenberg E, Thompson P, Ishida Y, Brennan P, Jolly KW, Termuhlen AM, Taylor M, Barcellos LF, Buffler PA
• Tobacco smoke exposure and the risk of childhood acute lymphoblastic and myeloid leukemias by cytogenetic subtype.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2013 Metayer C, Zhang L, Wiemels JL, Bartley K, Schiffman J, Ma X, Aldrich MC, Chang JS, Selvin S, Fu CH, Ducore J, Smith MT, Buffler PA
• Genetic variants in ARID5B and CEBPE are childhood ALL susceptibility loci in Hispanics.
  Cancer causes & control : CCC 2013 Chokkalingam AP, Hsu LI, Metayer C, Hansen HM, Month SR, Barcellos LF, Wiemels JL, Buffler PA
• Novel childhood ALL susceptibility locus BMI1-PIP4K2A is specifically associated with the hyperdiploid subtype.
  Blood 2013 Walsh KM, de Smith AJ, Chokkalingam AP, Metayer C, Dahl GV, Hsu LI, Barcellos LF, Wiemels JL, Buffler PA
• Associations between genome-wide Native American ancestry, known risk alleles and B-cell ALL risk in Hispanic children.
  Leukemia 2013 Walsh KM, Chokkalingam AP, Hsu LI, Metayer C, de Smith AJ, Jacobs DI, Dahl GV, Loh ML, Smirnov IV, Bartley K, Ma X, Wiencke JK, Barcellos LF, Wiemels JL, Buffler PA
• Blood levels of folate at birth and risk of childhood leukemia.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2013 Chokkalingam AP, Chun DS, Noonan EJ, Pfeiffer CM, Zhang M, Month SR, Taggart DR, Wiemels JL, Metayer C, Buffler PA
• Dental x-rays and risk of meningioma: response to Drs. Calnon, Jorgensen, and White.
  Cancer 2012 Claus EB, Wiemels J, Wrensch M
• Assessment of autoantibodies to meningioma in a population-based study.
  American journal of epidemiology 2012 Wiemels JL, Bracci PM, Wrensch M, Schildkraut J, Bondy M, Pfefferle J, Zhou M, Sison J, Calvocoressi L, Claus EB
• Allergy and risk of childhood acute lymphoblastic leukemia: a population-based and record-based study.
  American journal of epidemiology 2012 Chang JS, Tsai YW, Tsai CR, Wiemels JL
• Epigenetic biomarkers of T-cells in human glioma.
  Epigenetics 2012 Wiencke JK, Accomando WP, Zheng S, Patoka J, Dou X, Phillips JJ, Hsuang G, Christensen BC, Houseman EA, Koestler DC, Bracci P, Wiemels JL, Wrensch M, Nelson HH, Kelsey KT
• Exogenous hormone use, reproductive factors, and risk of intracranial meningioma in females.
  Journal of neurosurgery 2012 Claus EB, Calvocoressi L, Bondy ML, Wrensch M, Wiemels JL, Schildkraut JM
• A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network.
  Nucleic acids research 2012 Lee ST, Xiao Y, Muench MO, Xiao J, Fomin ME, Wiencke JK, Zheng S, Dou X, de Smith A, Chokkalingam A, Buffler P, Ma X, Wiemels JL
• α-Fucosidases with different substrate specificities from two species of Fusarium.
  Applied microbiology and biotechnology 2012 Paper JM, Scott-Craig JS, Cavalier D, Faik A, Wiemels RE, Borrusch MS, Bongers M, Walton JD
• HLA-DP genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia risk.
  Blood 2012 Urayama KY, Chokkalingam AP, Metayer C, Ma X, Selvin S, Barcellos LF, Wiemels JL, Wiencke JK, Taylor M, Brennan P, Dahl GV, Moonsamy P, Erlich HA, Trachtenberg E, Buffler PA
• Genome-wide association study of glioma and meta-analysis.
  Human genetics 2012 Rajaraman P, Melin BS, Wang Z, McKean-Cowdin R, Michaud DS, Wang SS, Bondy M, Houlston R, Jenkins RB, Wrensch M, Yeager M, Ahlbom A, Albanes D, Andersson U, Freeman LE, Buring JE, Butler MA, Braganza …
• Fetal growth and body size genes and risk of childhood acute lymphoblastic leukemia.
  Cancer causes & control : CCC 2012 Chokkalingam AP, Metayer C, Scelo G, Chang JS, Schiffman J, Urayama KY, Ma X, Hansen HM, Feusner JH, Barcellos LF, Wiencke JK, Wiemels JL, Buffler PA
• Medically diagnosed infections and risk of childhood leukaemia: a population-based case-control study.
  International journal of epidemiology 2012 Chang JS, Tsai CR, Tsai YW, Wiemels JL
• Variation in xenobiotic transport and metabolism genes, household chemical exposures, and risk of childhood acute lymphoblastic leukemia.
  Cancer causes & control : CCC 2012 Chokkalingam AP, Metayer C, Scelo GA, Chang JS, Urayama KY, Aldrich MC, Guha N, Hansen HM, Dahl GV, Barcellos LF, Wiencke JK, Wiemels JL, Buffler PA
• Key epigenetic changes associated with lung cancer development: results from dense methylation array profiling.
  Epigenetics 2012 Nelson HH, Marsit CJ, Christensen BC, Houseman EA, Kontic M, Wiemels JL, Karagas MR, Wrensch MR, Zheng S, Wiencke JK, Kelsey KT
• Occurrence of ²¹⁰Po and biological effects of low-level exposure: the need for research.
  Environmental health perspectives 2012 Seiler RL, Wiemels JL
• Serum autoantibodies to pancreatic cancer antigens as biomarkers of pancreatic cancer in a San Francisco Bay Area case-control study.
  Cancer 2012 Bracci PM, Zhou M, Young S, Wiemels J
• Dental x-rays and risk of meningioma.
  Cancer 2012 Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M
• Cigarette smoking and risk of meningioma: the effect of gender.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2012 Claus EB, Walsh KM, Calvocoressi L, Bondy ML, Schildkraut JM, Wrensch M, Wiemels JL
• Perspectives on the causes of childhood leukemia.
  Chemico-biological interactions 2012 Wiemels J
• Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia.
  BMC cancer 2012 Mansur MB, Hassan R, Barbosa TC, Splendore A, Jotta PY, Yunes JA, Wiemels JL, Pombo-de-Oliveira MS
• History of Parvovirus B19 infection is associated with a DNA methylation signature in childhood acute lymphoblastic leukemia.
  Epigenetics 2011 Vasconcelos GM, Christensen BC, Houseman EA, Xiao J, Marsit CJ, Wiencke JK, Zheng S, Karagas MR, Nelson HH, Wrensch MR, Kelsey KT, Pombo-de-Oliveira MS, Wiemels JL
• Molecular pathogenesis of secondary acute promyelocytic leukemia.
  Mediterranean journal of hematology and infectious diseases 2011 Joannides M, Mays AN, Mistry AR, Hasan SK, Reiter A, Wiemels JL, Felix CA, Coco FL, Osheroff N, Solomon E, Grimwade D
• Haplotypes of DNA repair and cell cycle control genes, X-ray exposure, and risk of childhood acute lymphoblastic leukemia.
  Cancer causes & control : CCC 2011 Chokkalingam AP, Bartley K, Wiemels JL, Metayer C, Barcellos LF, Hansen HM, Aldrich MC, Guha N, Urayama KY, Scélo G, Chang JS, Month SR, Wiencke JK, Buffler PA
• Matching on Race and Ethnicity in Case-Control Studies as a Means of Control for Population Stratification.
  Epidemiology (Sunnyvale, Calif.) 2011 Chokkalingam AP, Aldrich MC, Bartley K, Hsu LI, Metayer C, Barcellos LF, Wiemels JL, Wiencke JK, Buffler PA, Selvin S
• Risk of squamous cell carcinoma of the skin in relation to IgE: a nested case-control study.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2011 Wiemels JL, Wiencke JK, Li Z, Ramos C, Nelson HH, Karagas MR
• Family and personal medical history and risk of meningioma.
  Journal of neurosurgery 2011 Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M
• Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia.
  Cancer causes & control : CCC 2011 Metayer C, Scélo G, Chokkalingam AP, Barcellos LF, Aldrich MC, Chang JS, Guha N, Urayama KY, Hansen HM, Block G, Kiley V, Wiencke JK, Wiemels JL, Buffler PA
• Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking.
  American journal of epidemiology 2011 Lachance DH, Yang P, Johnson DR, Decker PA, Kollmeyer TM, McCoy LS, Rice T, Xiao Y, Ali-Osman F, Wang F, Stoddard SM, Sprau DJ, Kosel ML, Wiencke JK, Wiemels JL, Patoka JS, Davis F, McCarthy B, …
• Profound deficit of IL10 at birth in children who develop childhood acute lymphoblastic leukemia.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2011 Chang JS, Zhou M, Buffler PA, Chokkalingam AP, Metayer C, Wiemels JL
• Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls.
  International journal of cancer 2011 Wiemels JL, Wrensch M, Sison JD, Zhou M, Bondy M, Calvocoressi L, Black PM, Yu H, Schildkraut JM, Claus EB
• DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression.
  Neuro-oncology 2011 Zheng S, Houseman EA, Morrison Z, Wrensch MR, Patoka JS, Ramos C, Haas-Kogan DA, McBride S, Marsit CJ, Christensen BC, Nelson HH, Stokoe D, Wiemels JL, Chang SM, Prados MD, Tihan T, Vandenberg SR, …
• Unusual space-time patterning of the Fallon, Nevada leukemia cluster: Evidence of an infectious etiology.
  Chemico-biological interactions 2011 Francis SS, Selvin S, Yang W, Buffler PA, Wiemels JL
• Distinct germ line polymorphisms underlie glioma morphologic heterogeneity.
  Cancer genetics 2011 Jenkins RB, Wrensch MR, Johnson D, Fridley BL, Decker PA, Xiao Y, Kollmeyer TM, Rynearson AL, Fink S, Rice T, McCoy LS, Halder C, Kosel ML, Giannini C, Tihan T, O'Neill BP, Lachance DH, Yang P, …
• Early life exposure to infections and risk of childhood acute lymphoblastic leukemia.
  International journal of cancer 2010 Urayama KY, Ma X, Selvin S, Metayer C, Chokkalingam AP, Wiemels JL, Does M, Chang J, Wong A, Trachtenberg E, Buffler PA
• DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma.
  Journal of the National Cancer Institute 2010 Christensen BC, Smith AA, Zheng S, Koestler DC, Houseman EA, Marsit CJ, Wiemels JL, Nelson HH, Karagas MR, Wrensch MR, Kelsey KT, Wiencke JK
• FLT3 mutation incidence and timing of origin in a population case series of pediatric leukemia.
  BMC cancer 2010 Chang P, Kang M, Xiao A, Chang J, Feusner J, Buffler P, Wiemels J
• Epidemiology and etiology of meningioma.
  Journal of neuro-oncology 2010 Wiemels J, Wrensch M, Claus EB
• TEL-AML1 regulation of survivin and apoptosis via miRNA-494 and miRNA-320a.
  Blood 2010 Diakos C, Zhong S, Xiao Y, Zhou M, Vasconcelos GM, Krapf G, Yeh RF, Zheng S, Kang M, Wiencke JK, Pombo-de-Oliveira MS, Panzer-Grümayer R, Wiemels JL
• Identification of methylated genes associated with aggressive bladder cancer.
  PloS one 2010 Marsit CJ, Houseman EA, Christensen BC, Gagne L, Wrensch MR, Nelson HH, Wiemels J, Zheng S, Wiencke JK, Andrew AS, Schned AR, Karagas MR, Kelsey KT
• Circulating levels of the innate and humoral immune regulators CD14 and CD23 are associated with adult glioma.
  Cancer research 2010 Zhou M, Wiemels JL, Bracci PM, Wrensch MR, McCoy LS, Rice T, Sison JD, Patoka JS, Wiencke JK
• Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010 Chang JS, Wiemels JL, Chokkalingam AP, Metayer C, Barcellos LF, Hansen HM, Aldrich MC, Guha N, Urayama KY, Scélo G, Green J, May SL, Kiley VA, Wiencke JK, Buffler PA
• Analysis of genomic breakpoints in p190 and p210 BCR-ABL indicate distinct mechanisms of formation.
  Leukemia 2010 Score J, Calasanz MJ, Ottman O, Pane F, Yeh RF, Sobrinho-Simões MA, Kreil S, Ward D, Hidalgo-Curtis C, Melo JV, Wiemels J, Nadel B, Cross NC, Grand FH
• Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia.
  Blood cells, molecules & diseases 2010 Wiemels JL, Kang M, Chang JS, Zheng L, Kouyoumji C, Zhang L, Smith MT, Scelo G, Metayer C, Buffler P, Wiencke JK
• Analysis of t(15;17) chromosomal breakpoint sequences in therapy-related versus de novo acute promyelocytic leukemia: association of DNA breaks with specific DNA motifs at PML and RARA loci.
  Genes, chromosomes & cancer 2010 Hasan SK, Ottone T, Schlenk RF, Xiao Y, Wiemels JL, Mitra ME, Bernasconi P, Di Raimondo F, Stanghellini MT, Marco P, Mays AN, Döhner H, Sanz MA, Amadori S, Grimwade D, Lo-Coco F
• Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intake.
  PLoS genetics 2010 Christensen BC, Kelsey KT, Zheng S, Houseman EA, Marsit CJ, Wrensch MR, Wiemels JL, Nelson HH, Karagas MR, Kushi LH, Kwan ML, Wiencke JK
• Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia.
  Blood 2009 Mays AN, Osheroff N, Xiao Y, Wiemels JL, Felix CA, Byl JA, Saravanamuttu K, Peniket A, Corser R, Chang C, Hoyle C, Parker AN, Hasan SK, Lo-Coco F, Solomon E, Grimwade D
• Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context.
  PLoS genetics 2009 Christensen BC, Houseman EA, Marsit CJ, Zheng S, Wrensch MR, Wiemels JL, Nelson HH, Karagas MR, Padbury JF, Bueno R, Sugarbaker DJ, Yeh RF, Wiencke JK, Kelsey KT
• IgE, allergy, and risk of glioma: update from the San Francisco Bay Area Adult Glioma Study in the temozolomide era.
  International journal of cancer 2009 Wiemels JL, Wilson D, Patil C, Patoka J, McCoy L, Rice T, Schwartzbaum J, Heimberger A, Sampson JH, Chang S, Prados M, Wiencke JK, Wrensch M
• Differentiation of lung adenocarcinoma, pleural mesothelioma, and nonmalignant pulmonary tissues using DNA methylation profiles.
  Cancer research 2009 Christensen BC, Marsit CJ, Houseman EA, Godleski JJ, Longacker JL, Zheng S, Yeh RF, Wrensch MR, Wiemels JL, Karagas MR, Bueno R, Sugarbaker DJ, Nelson HH, Wiencke JK, Kelsey KT
• Maternal immunoglobulin E and childhood leukemia.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009 Chang JS, Buffler PA, Metayer C, Chokkalingam AP, Patoka J, Kronish D, Wiemels JL
• Copy number variation has little impact on bead-array-based measures of DNA methylation.
  Bioinformatics (Oxford, England) 2009 Houseman EA, Christensen BC, Karagas MR, Wrensch MR, Nelson HH, Wiemels JL, Zheng S, Wiencke JK, Kelsey KT, Marsit CJ
• 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia.
  Anesthesiology 2009 Sapru A, Hansen H, Ajayi T, Brown R, Garcia O, Zhuo H, Wiemels J, Matthay MA, Wiener-Kronish J
• Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma.
  Carcinogenesis 2009 Marsit CJ, Christensen BC, Houseman EA, Karagas MR, Wrensch MR, Yeh RF, Nelson HH, Wiemels JL, Zheng S, Posner MR, McClean MD, Wiencke JK, Kelsey KT
• Backtracking of leukemic clones to birth.
  Methods in molecular biology (Clifton, N.J.) 2009 Wiemels J, Kang M, Greaves M
• Infection and pediatric acute lymphoblastic leukemia.
  Blood cells, molecules & diseases 2008 Ma X, Urayama K, Chang J, Wiemels JL, Buffler PA
• Allergies and childhood leukemia.
  Blood cells, molecules & diseases 2008 Chang JS, Wiemels JL, Buffler PA
• Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally.
  Cancer research 2008 Wiemels JL, Hofmann J, Kang M, Selzer R, Green R, Zhou M, Zhong S, Zhang L, Smith MT, Marsit C, Loh M, Buffler P, Yeh RF
• The molecular anatomy of the FIP1L1-PDGFRA fusion gene.
  Leukemia 2008 Walz C, Score J, Mix J, Cilloni D, Roche-Lestienne C, Yeh RF, Wiemels JL, Ottaviani E, Erben P, Hochhaus A, Baccarani M, Grimwade D, Preudhomme C, Apperley J, Martinelli G, Saglio G, Cross NC, Reiter …
• SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization system.
  Nucleic acids research 2008 Pico AR, Smirnov IV, Chang JS, Yeh RF, Wiemels JL, Wiencke JK, Tihan T, Conklin BR, Wrensch M
• Adenovirus detection in Guthrie cards from paediatric leukaemia cases and controls.
  British journal of cancer 2008 Vasconcelos GM, Kang M, Pombo-de-Oliveira MS, Schiffman JD, Lorey F, Buffler P, Wiemels JL
• NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis.
  American journal of epidemiology 2008 Guha N, Chang JS, Chokkalingam AP, Wiemels JL, Smith MT, Buffler PA
• Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia.
  Environmental health perspectives 2008 Scélo G, Metayer C, Zhang L, Wiemels JL, Aldrich MC, Selvin S, Month S, Smith MT, Buffler PA
• Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium.
  Cancer 2008 Bondy ML, Scheurer ME, Malmer B, Barnholtz-Sloan JS, Davis FG, Il'yasova D, Kruchko C, McCarthy BJ, Rajaraman P, Schwartzbaum JA, Sadetzki S, Schlehofer B, Tihan T, Wiemels JL, Wrensch M, Buffler PA, …
• Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions.
  BMC bioinformatics 2008 Houseman EA, Christensen BC, Yeh RF, Marsit CJ, Karagas MR, Wrensch M, Nelson HH, Wiemels J, Zheng S, Wiencke JK, Kelsey KT
• Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forests.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008 Chang JS, Yeh RF, Wiencke JK, Wiemels JL, Smirnov I, Pico AR, Tihan T, Patoka J, Miike R, Sison JD, Rice T, Wrensch MR
• Chromosomal translocations in childhood leukemia: natural history, mechanisms, and epidemiology.
  Journal of the National Cancer Institute. Monographs 2008 Wiemels J
• Epidemiology of brain tumors.
  Neurologic clinics 2007 Fisher JL, Schwartzbaum JA, Wrensch M, Wiemels JL
• DNA quantification of whole genome amplified samples for genotyping on a multiplexed bead array platform.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007 Hansen HM, Wiemels JL, Wrensch M, Wiencke JK
• Exogenous hormone use and meningioma risk: what do we tell our patients?
  Cancer 2007 Claus EB, Black PM, Bondy ML, Calvocoressi L, Schildkraut JM, Wiemels JL, Wrensch M
• Allergy-related polymorphisms influence glioma status and serum IgE levels.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007 Wiemels JL, Wiencke JK, Kelsey KT, Moghadassi M, Rice T, Urayama KY, Miike R, Wrensch M
• MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007 Urayama KY, Wiencke JK, Buffler PA, Chokkalingam AP, Metayer C, Wiemels JL
• Identification of two distinct MYC breakpoint clusters and their association with various IGH breakpoint regions in the t(8;14) translocations in sporadic Burkitt-lymphoma.
  Leukemia 2007 Busch K, Keller T, Fuchs U, Yeh RF, Harbott J, Klose I, Wiemels J, Novosel A, Reiter A, Borkhardt A
• Accuracy of multiplexed Illumina platform-based single-nucleotide polymorphism genotyping compared between genomic and whole genome amplified DNA collected from multiple sources.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006 Paynter RA, Skibola DR, Skibola CF, Buffler PA, Wiemels JL, Smith MT
• Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways.
  Intensive care medicine 2006 Sapru A, Wiemels JL, Witte JS, Ware LB, Matthay MA
• Cytogenetics of Hispanic and White children with acute lymphoblastic leukemia in California.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006 Aldrich MC, Zhang L, Wiemels JL, Ma X, Loh ML, Metayer C, Selvin S, Feusner J, Smith MT, Buffler PA
• Epidemiology of intracranial meningioma.
  Neurosurgery 2005 Claus EB, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M, Black PM
• ERCC1 and ERCC2 polymorphisms and adult glioma.
  Neuro-oncology 2005 Wrensch M, Kelsey KT, Liu M, Miike R, Moghadassi M, Sison JD, Aldape K, McMillan A, Wiemels J, Wiencke JK
• Breastfeeding patterns and risk of childhood acute lymphoblastic leukaemia.
  British journal of cancer 2005 Kwan ML, Buffler PA, Wiemels JL, Metayer C, Selvin S, Ducore JM, Block G
• Molecular biomarkers for the study of childhood leukemia.
  Toxicology and applied pharmacology 2005 Smith MT, McHale CM, Wiemels JL, Zhang L, Wiencke JK, Zheng S, Gunn L, Skibola CF, Ma X, Buffler PA
• Ethnic difference in daycare attendance, early infections, and risk of childhood acute lymphoblastic leukemia.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005 Ma X, Buffler PA, Wiemels JL, Selvin S, Metayer C, Loh M, Does MB, Wiencke JK
• History of chickenpox and shingles and prevalence of antibodies to varicella-zoster virus and three other herpesviruses among adults with glioma and controls.
  American journal of epidemiology 2005 Wrensch M, Weinberg A, Wiencke J, Miike R, Sison J, Wiemels J, Barger G, DeLorenze G, Aldape K, Kelsey K
• DNA topoisomerase II in therapy-related acute promyelocytic leukemia.
  The New England journal of medicine 2005 Mistry AR, Felix CA, Whitmarsh RJ, Mason A, Reiter A, Cassinat B, Parry A, Walz C, Wiemels JL, Segal MR, Adès L, Blair IA, Osheroff N, Peniket AJ, Lafage-Pochitaloff M, Cross NC, Chomienne C, Solomon …
• RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia.
  Leukemia 2005 Wiemels JL, Zhang Y, Chang J, Zheng S, Metayer C, Zhang L, Smith MT, Ma X, Selvin S, Buffler PA, Wiencke JK
• Reduced immunoglobulin E and allergy among adults with glioma compared with controls.
  Cancer research 2004 Wiemels JL, Wiencke JK, Patoka J, Moghadassi M, Chew T, McMillan A, Miike R, Barger G, Wrensch M
• Protracted postnatal natural histories in childhood leukemia.
  Genes, chromosomes & cancer 2004 Maia AT, Koechling J, Corbett R, Metzler M, Wiemels JL, Greaves M
• Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia.
  Cancer research 2004 Zheng S, Ma X, Zhang L, Gunn L, Smith MT, Wiemels JL, Leung K, Buffler PA, Wiencke JK
• Leukemia in twins: lessons in natural history.
  Blood 2003 Greaves MF, Maia AT, Wiemels JL, Ford AM
• Prenatal origin of childhood acute myeloid leukemias harboring chromosomal rearrangements t(15;17) and inv(16).
  Blood 2003 McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Feusner J, Matthay K, Dahl G, Smith MT
• Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California.
  Genes, chromosomes & cancer 2003 McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Guo W, Loh ML, Smith MT
• Genomic anatomy of the specific reciprocal translocation t(15;17) in acute promyelocytic leukemia.
  Genes, chromosomes & cancer 2003 Reiter A, Saussele S, Grimwade D, Wiemels JL, Segal MR, Lafage-Pochitaloff M, Walz C, Weisser A, Hochhaus A, Willer A, Reichert A, Büchner T, Lengfelder E, Hehlmann R, Cross NC
• Real-time quantitative PCR: standardized detection of minimal residual disease in pediatric acute lymphoblastic leukemia. Polymerase chain reaction.
  Journal of pediatric hematology/oncology 2003 Pine SR, Moy FH, Wiemels JL, Gill RK, Levendoglu-Tugal O, Ozkaynak MF, Sandoval C, Jayabose S
• TEL-AML1 fusion precedes differentiation to pre-B cells in childhood acute lymphoblastic leukemia.
  Leukemia research 2003 Pine SR, Wiemels JL, Jayabose S, Sandoval C
• Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SR
• In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia.
  Blood 2002 Wiemels JL, Xiao Z, Buffler PA, Maia AT, Ma X, Dicks BM, Smith MT, Zhang L, Feusner J, Wiencke J, Pritchard-Jones K, Kempski H, Greaves M
• Daycare attendance and risk of childhood acute lymphoblastic leukaemia.
  British journal of cancer 2002 Ma X, Buffler PA, Selvin S, Matthay KK, Wiencke JK, Wiemels JL, Reynolds P
• History of allergies among adults with glioma and controls.
  International journal of cancer 2002 Wiemels JL, Wiencke JK, Sison JD, Miike R, McMillan A, Wrensch M
• Molecular characterization of genomic AML1-ETO fusions in childhood leukemia.
  Leukemia 2001 Xiao Z, Greaves MF, Buffler P, Smith MT, Segal MR, Dicks BM, Wiencke JK, Wiemels JL
• Markers for carcinogenicity among butadiene-polymer workers in China.
  Chemico-biological interactions 2001 Hayes RB, Zhang L, Swenberg JA, Yin SN, Xi L, Wiencke J, Bechtold WE, Yao M, Rothman N, Haas R, O'Neill JP, Wiemels J, Dosemeci M, Li G, Smith MT
• Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion.
  Cancer research 2001 Alexander FE, Patheal SL, Biondi A, Brandalise S, Cabrera ME, Chan LC, Chen Z, Cimino G, Cordoba JC, Gu LJ, Hussein H, Ishii E, Kamel AM, Labra S, Magalhães IQ, Mizutani S, Petridou E, de Oliveira MP,…
• Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Wiemels JL, Smith RN, Taylor GM, Eden OB, Alexander FE, Greaves MF, United Kingdom Childhood Cancer Study investigators
• Low NAD(P)H:quinone oxidoreductase 1 activity is associated with increased risk of acute leukemia in adults.
  Blood 2001 Smith MT, Wang Y, Kane E, Rollinson S, Wiemels JL, Roman E, Roddam P, Cartwright R, Morgan G
• Microclustering of TEL-AML1 translocation breakpoints in childhood acute lymphoblastic leukemia.
  Genes, chromosomes & cancer 2000 Wiemels JL, Alexander FE, Cazzaniga G, Biondi A, Mayer SP, Greaves M
• Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2000 Naoe T, Takeyama K, Yokozawa T, Kiyoi H, Seto M, Uike N, Ino T, Utsunomiya A, Maruta A, Jin-nai I, Kamada N, Kubota Y, Nakamura H, Shimazaki C, Horiike S, Kodera Y, Saito H, Ueda R, Wiemels J, Ohno R
• Genotoxic markers among butadiene polymer workers in China.
  Carcinogenesis 2000 Hayes RB, Zhang L, Yin S, Swenberg JA, Xi L, Wiencke J, Bechtold WE, Yao M, Rothman N, Haas R, O'Neill JP, Zhang D, Wiemels J, Dosemeci M, Li G, Smith MT
• Prenatal origin of acute lymphoblastic leukaemia in children.
  Lancet (London, England) 1999 Wiemels JL, Cazzaniga G, Daniotti M, Eden OB, Addison GM, Masera G, Saha V, Biondi A, Greaves MF
• A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions. United Kingdom Childhood Cancer Study Investigators.
  Cancer research 1999 Wiemels JL, Pagnamenta A, Taylor GM, Eden OB, Alexander FE, Greaves MF
• Structure and possible mechanisms of TEL-AML1 gene fusions in childhood acute lymphoblastic leukemia.
  Cancer research 1999 Wiemels JL, Greaves M
• Protracted and variable latency of acute lymphoblastic leukemia after TEL-AML1 gene fusion in utero.
  Blood 1999 Wiemels JL, Ford AM, Van Wering ER, Postma A, Greaves M
• Prevalence of the inactivating 609C-->T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia.
  Blood 1999 Larson RA, Wang Y, Banerjee M, Wiemels J, Hartford C, Le Beau MM, Smith MT
• Modulation of the toxicity and macromolecular binding of benzene metabolites by NAD(P)H:Quinone oxidoreductase in transfected HL-60 cells.
  Chemical research in toxicology 1999 Wiemels J, Wiencke JK, Varykoni A, Smith MT
• Enhancement of myeloid cell growth by benzene metabolites via the production of active oxygen species.
  Free radical research 1999 Wiemels J, Smith MT
• Increased translocations and aneusomy in chromosomes 8 and 21 among workers exposed to benzene.
  Cancer research 1998 Smith MT, Zhang L, Wang Y, Hayes RB, Li G, Wiemels J, Dosemeci M, Titenko-Holland N, Xi L, Kolachana P, Yin S, Rothman N
• An epidemiologic study of early biologic effects of benzene in Chinese workers.
  Environmental health perspectives 1996 Rothman N, Smith MT, Hayes RB, Li GL, Irons RD, Dosemeci M, Haas R, Stillman WS, Linet M, Xi LQ, Bechtold WE, Wiemels J, Campleman S, Zhang L, Quintana PJ, Titenko-Holland N, Wang YZ, Lu W, Kolachana …
• hprt mutation frequency among workers exposed to 1,3-butadiene in China.
  Toxicology 1996 Hayes RB, Xi L, Bechtold WE, Rothman N, Yao M, Henderson R, Zhang L, Smith MT, Zhang D, Wiemels J, Dosemeci M, Yin S, O'Neill JP
• Genotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
  Mutation research 1995 Wiencke JK, Wiemels J
• Benzene induces gene-duplicating but not gene-inactivating mutations at the glycophorin A locus in exposed humans.
  Proceedings of the National Academy of Sciences of the United States of America 1995 Rothman N, Haas R, Hayes RB, Li GL, Wiemels J, Campleman S, Quintana PJ, Xi LJ, Dosemeci M, Titenko-Holland N
• Chemical exposure, ras oncogene activation, and acute myeloid leukemia.
  Journal of the National Cancer Institute 1992 Smith MT, Wiemels J, Rothman N, Linet MS
• Ethoxyformylation of tubulin with [3H]diethyl pyrocarbonate: a reexamination of the mechanism of assembly inhibition.
  Biochemistry 1989 Levison BS, Wiemels J, Szasz J, Sternlicht H