Jody Baron, MD, PhD
Professor
Medicine
School of Medicine
Grants and Projects
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- Clinical & Immunological Study of Treatment Withdrawal in E-Ag Negative Hepatitis B, NIH, 2016-2026
- Identifying and modulating therapeutic targets in a model of hepatitis B, NIH, 2018-2022
- Identifying and modulating therapeutic targets in a model of hepatitis B, NIH, 2012-2018
- Identifying and modulating therapeutic targets in a model of hepatitis B, NIH, 2012-2017
- Age-dependent immune responses to hepatitis B: a mouse model of human disease, NIH, 2011-2013
- Understanding Immunopathogenesis of Hepatitis B Virus, NIH, 2006-2012
Publications (29)
Top publication keywords:
Lymphoid TissueTumor EscapeChemokine CXCL13LiverInterleukinsKiller Cells, NaturalTransforming Growth Factor betaOX40 LigandImmunity, InnateHepatitis B, ChronicInterleukin-1betaHepatitis B virusIntegrinsHepatitis BReceptors, OX40
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Hepatitis C virus infects and perturbs liver stem cells.
mBio 2023 Meyers NL, Ashuach T, Lyons DE, Khalid MM, Simoneau CR, Erickson AL, Bouhaddou M, Nguyen TT, Kumar GR, Taha TY, Natarajan V, Baron JL, Neff N, Zanini F, Mahmoudi T, Quake SR, Krogan NJ, Cooper S, … -
Cyclone: an accessible pipeline to analyze, evaluate, and optimize multiparametric cytometry data.
Frontiers in immunology 2023 Patel RK, Jaszczak RG, Im K, Carey ND, Courau T, Bunis DG, Samad B, Avanesyan L, Chew NW, Stenske S, Jespersen JM, Publicover J, Edwards AW, Naser M, Rao AA, Lupin-Jimenez L, Krummel MF, Cooper S, … -
Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system.
Open biology 2022 Natarajan V, Simoneau CR, Erickson AL, Meyers NL, Baron JL, Cooper S, McDevitt TC, Ott M -
A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8.
Science immunology 2021 Seed RI, Kobayashi K, Ito S, Takasaka N, Cormier A, Jespersen JM, Publicover J, Trilok S, Combes AJ, Chew NW, Chapman J, Krummel MF, Lou J, Marks J, Cheng Y, Baron JL, Nishimura SL -
Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β.
Cell 2020 Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL
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Structural Studies avß8 Integrin by Single Particle Cryo-EM.
Microscopy and Microanalysis 2019 Melody G. Campbell, Anthony Cormier, Saburo Ito, Shenping Wu, Jianlong Lou, James Marks, Jody L. Baron, Stephen L. Nishimura, Yifan Cheng -
Integrin αvβ8-expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells.
JCI insight 2018 Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron … -
Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension.
Nature structural & molecular biology 2018 Cormier A, Campbell MG, Ito S, Wu S, Lou J, Marks J, Baron JL, Nishimura SL, Cheng Y -
An OX40/OX40L interaction directs successful immunity to hepatitis B virus.
Science translational medicine 2018 Publicover J, Gaggar A, Jespersen JM, Halac U, Johnson AJ, Goodsell A, Avanesyan L, Nishimura SL, Holdorf M, Mansfield KG, Judge JB, Koshti A, Croft M, Wakil AE, Rosenthal P, Pai E, Cooper S, Baron JL -
CD18 deficiency improves liver injury in the MCD model of steatohepatitis.
PloS one 2017 Pierce AA, Duwaerts CC, Siao K, Mattis AN, Goodsell A, Baron JL, Maher JJ -
Specific Macronutrients Exert Unique Influences on the Adipose-Liver Axis to Promote Hepatic Steatosis in Mice.
Cellular and molecular gastroenterology and hepatology 2017 Duwaerts CC, Amin AM, Siao K, Her C, Fitch M, Beysen C, Turner SM, Goodsell A, Baron JL, Grenert JP, Cho SJ, Maher JJ -
Role of IL-17A in murine models of COPD airway disease.
American journal of physiology. Lung cellular and molecular physiology 2016 Yanagisawa H, Hashimoto M, Minagawa S, Takasaka N, Ma R, Moermans C, Ito S, Araya J, Budelsky A, Goodsell A, Baron JL, Nishimura SL -
Liver capsule: Age-influenced hepatic immune priming determines HBV infection fate: Implications from mouse to man.
Hepatology (Baltimore, Md.) 2015 Publicover J, Jespersen JM, Johnson AJ, Nishimura SL, Goodsell A, Wakil AE, Rosenthal P, Pai E, Avanesyan L, Cooper S, Baron JL -
TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease.
Journal of immunology (Baltimore, Md. : 1950) 2015 Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL -
Transforming Growth Factor-β and Interleukin-1β Signaling Pathways Converge on the Chemokine CCL20 Promoter.
The Journal of biological chemistry 2015 Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura SL -
A critical role for dendritic cells in the evolution of IL-1β-mediated murine airway disease.
Journal of immunology (Baltimore, Md. : 1950) 2015 Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Goodsell A, Ma R, Moermans C, McKnelly KJ, Baron JL, Krummel MF, Nishimura SL -
Selective targeting of TGF-β activation to treat fibroinflammatory airway disease.
Science translational medicine 2014 Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ… -
Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice.
PloS one 2013 Fomin ME, Zhou Y, Beyer AI, Publicover J, Baron JL, Muench MO -
S-3 Age-dependent hepatic lymphoid organization directs immune priming, cytokine production, and successful immunity to Hepatitis B virus.
Cytokine 2013 Jean Publicover, Anuj Gaggar, Stephen Nishimura, Christine M. Van Horn, Amanda Goodsell, Marcus O. Muench, R. Lee Reinhardt, Nico van Rooijen, Adil E. Wakil Marion Peters, Jason G. Cyster, David J. … -
Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B.
The Journal of clinical investigation 2013 Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL -
Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity.
Nature medicine 2012 Zeissig S, Murata K, Sweet L, Publicover J, Hu Z, Kaser A, Bosse E, Iqbal J, Hussain MM, Balschun K, Röcken C, Arlt A, Günther R, Hampe J, Schreiber S, Baron JL, Moody DB, Liang TJ, Blumberg RS -
742 Hepatitis B Virus Infection Leads to Alterations in the Repertoire of Self Lipid Antigens Presented by Hepatocytes and is Associated With Direct and Indirect Activation of Natural Killer T Cells.
Gastroenterology 2012 Sebastian Zeissig, Kazumoto Murata, Lindsay Sweet, Jean Publicover, Zongyi Hu, Arthur Kaser, Alexander Arlt, Rainer Günther, Jochen Hampe, Stefan Schreiber, Jody Baron, D. Branch Moody, T Jake Liang, … -
Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β.
The Journal of clinical investigation 2011 Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL -
IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B.
The Journal of clinical investigation 2011 Publicover J, Goodsell A, Nishimura S, Vilarinho S, Wang ZE, Avanesyan L, Spolski R, Leonard WJ, Cooper S, Baron JL -
Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus.
Proceedings of the National Academy of Sciences of the United States of America 2007 Vilarinho S, Ogasawara K, Nishimura S, Lanier LL, Baron JL -
Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function.
The Journal of experimental medicine 2003 Stetson DB, Mohrs M, Reinhardt RL, Baron JL, Wang ZE, Gapin L, Kronenberg M, Locksley RM -
Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2003 Matsuda JL, Gapin L, Baron JL, Sidobre S, Stetson DB, Mohrs M, Locksley RM, Kronenberg M -
The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1.
The Journal of cell biology 2002 Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, Broaddus VC, Nishimura SL -
Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2001 Cerwenka A, Baron JL, Lanier LL