Jim Sonner, MD
Professor Emeritus
Anesthesia
School of Medicine

Education & Training

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• M.D. School of Medicine Harvard University 1988
• Residency School of Medicine University of California, San Francisco

Grants and Projects

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• Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
• Sites and Mechanisms of Inhaled Anesthetic Actions, NIH/NIGMS, 1994-2010
• Genes Underlying the Response to Inhaled Anesthetics, NIH, 2004-2010

Publications (65)

Top publication keywords:
MovementImmobilizationAnesthetics, InhalationReceptors, GlycineIsofluraneAlcoholsAnestheticsXenopus laevisFearReceptors, CholinergicPulmonary AlveoliAnesthetics, IntravenousIon ChannelsReceptors, N-Methyl-D-AspartateReceptors, GABA-A

• Molecular mechanisms of drug action: an emerging view.
  Annual review of biophysics 2013 Sonner JM, Cantor RS
• 3-Hydroxybutyric acid interacts with lipid monolayers at concentrations that impair consciousness.
  Langmuir : the ACS journal of surfaces and colloids 2013 Hsu TT, Leiske DL, Rosenfeld L, Sonner JM, Fuller GG
• Gamma-aminobutyric acid type A receptor β3 subunit forebrain-specific knockout mice are resistant to the amnestic effect of isoflurane.
  Anesthesia and analgesia 2011 Rau V, Oh I, Liao M, Bodarky C, Fanselow MS, Homanics GE, Sonner JM, Eger EI
• Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Duret G, Van Renterghem C, Weng Y, Prevost M, Moraga-Cid G, Huon C, Sonner JM, Corringer PJ
• X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel.
  Nature 2011 Nury H, Van Renterghem C, Weng Y, Tran A, Baaden M, Dufresne V, Changeux JP, Sonner JM, Delarue M, Corringer PJ

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• Conserved role of unc-79 in ethanol responses in lightweight mutant mice.
  PLoS genetics 2010 Speca DJ, Chihara D, Ashique AM, Bowers MS, Pierce-Shimomura JT, Lee J, Rabbee N, Speed TP, Gularte RJ, Chitwood J, Medrano JF, Liao M, Sonner JM, Eger EI, Peterson AS, McIntire SL
• Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane.
  Anesthesia and analgesia 2009 Rau V, Iyer SV, Oh I, Chandra D, Harrison N, Eger EI, Fanselow MS, Homanics GE, Sonner JM
• Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel.
  Anesthesia and analgesia 2009 Weng Y, Yang L, Corringer PJ, Sonner JM
• Isovaleric, methylmalonic, and propionic acid decrease anesthetic EC50 in tadpoles, modulate glycine receptor function, and interact with the lipid 1,2-dipalmitoyl-Sn-glycero-3-phosphocholine.
  Anesthesia and analgesia 2009 Weng Y, Hsu TT, Zhao J, Nishimura S, Fuller GG, Sonner JM
• Tolerance to isoflurane does not occur in developing Xenopus laevis tadpoles.
  Anesthesia and analgesia 2009 Milutinovic PS, Zhao J, Sonner JM
• A hypothesis on the origin and evolution of the response to inhaled anesthetics.
  Anesthesia and analgesia 2008 Sonner JM
• Anesthetic-like modulation of receptor function by surfactants: a test of the interfacial theory of anesthesia.
  Anesthesia and analgesia 2008 Yang L, Sonner JM
• Is a new paradigm needed to explain how inhaled anesthetics produce immobility?
  Anesthesia and analgesia 2008 Eger EI, Raines DE, Shafer SL, Hemmings HC, Sonner JM
• Additivity versus synergy: a theoretical analysis of implications for anesthetic mechanisms.
  Anesthesia and analgesia 2008 Shafer SL, Hendrickx JF, Flood P, Sonner J, Eger EI
• Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats.
  Anesthesia and analgesia 2008 Eger EI, Tang M, Liao M, Laster MJ, Solt K, Flood P, Jenkins A, Raines D, Hendrickx JF, Shafer SL, Yasumasa T, Sonner JM
• Is synergy the rule? A review of anesthetic interactions producing hypnosis and immobility.
  Anesthesia and analgesia 2008 Hendrickx JF, Eger EI, Sonner JM, Shafer SL
• Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity.
  Behavioural brain research 2008 Yost CS, Oh I, Eger EI, Sonner JM
• Intrathecal glycine significantly decreases the minimum alveolar concentration of isoflurane in rats.
  Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 2008 Zhao J, Zhang Y, Eger EI, Sonner J
• The anesthetic-like effects of diverse compounds on wild-type and mutant gamma-aminobutyric acid type A and glycine receptors.
  Anesthesia and analgesia 2008 Yang L, Sonner JM
• Alterations in spinal, but not cerebral, cerebrospinal fluid Na+ concentrations affect the isoflurane minimum alveolar concentration in rats.
  Anesthesia and analgesia 2007 Laster MJ, Zhang Y, Eger EI, Shnayderman D, Sonner JM
• Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetone.
  Anesthesia and analgesia 2007 Yang L, Zhao J, Milutinovic PS, Brosnan RJ, Eger EI, Sonner JM
• Anesthetic-like modulation of a gamma-aminobutyric acid type A, strychnine-sensitive glycine, and N-methyl-d-aspartate receptors by coreleased neurotransmitters.
  Anesthesia and analgesia 2007 Milutinovic PS, Yang L, Cantor RS, Eger EI, Sonner JM
• Mouse chromosome 7 harbors a quantitative trait locus for isoflurane minimum alveolar concentration.
  Anesthesia and analgesia 2007 Cascio M, Xing Y, Gong D, Popovich J, Eger EI, Sen S, Peltz G, Sonner JM
• The plasticizer di(2-ethylhexyl) phthalate modulates gamma-aminobutyric acid type A and glycine receptor function.
  Anesthesia and analgesia 2007 Yang L, Milutinovic PS, Brosnan RJ, Eger EI, Sonner JM
• Anesthetic properties of carbon dioxide in the rat.
  Anesthesia and analgesia 2007 Brosnan RJ, Eger EI, Laster MJ, Sonner JM
• Ethnicity can affect anesthetic requirement.
  Anesthesiology 2007 Sonner JM
• Ammonia has anesthetic properties.
  Anesthesia and analgesia 2007 Brosnan RJ, Yang L, Milutinovic PS, Zhao J, Laster MJ, Eger EI, Sonner JM
• Lidocaine, MK-801, and MAC.
  Anesthesia and analgesia 2007 Zhang Y, Laster MJ, Eger EI, Sharma M, Sonner JM
• Blockade of acetylcholine receptors does not change the dose of etomidate required to produce immobility in rats.
  Anesthesia and analgesia 2007 Zhang Y, Laster MJ, Eger EI, Sharma M, Sonner JM
• Determination of the EC50 amnesic concentration of etomidate and its diffusion profile in brain tissue: implications for in vitro studies.
  Anesthesiology 2007 Benkwitz C, Liao M, Laster MJ, Sonner JM, Eger EI, Pearce RA
• Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane.
  Anesthesiology 2007 Sonner JM, Werner DF, Elsen FP, Xing Y, Liao M, Harris RA, Harrison NL, Fanselow MS, Eger EI, Homanics GE
• Do dopamine receptors mediate part of MAC?
  Anesthesia and analgesia 2006 Tanifuji Y, Zhang Y, Liao M, Eger EI, Laster MJ, Sonner JM
• Chirality in anesthesia I: minimum alveolar concentration of secondary alcohol enantiomers.
  Anesthesia and analgesia 2006 Won A, Oh I, Laster MJ, Popovich J, Eger EI, Sonner JM
• Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomers.
  Anesthesia and analgesia 2006 Brosnan R, Gong D, Cotten J, Keshavaprasad B, Yost CS, Eger EI, Sonner JM
• Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics.
  Anesthesia and analgesia 2006 Eger EI, Liao M, Laster MJ, Won A, Popovich J, Raines DE, Solt K, Dutton RC, Cobos FV, Sonner JM
• Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration?
  Anesthesia and analgesia 2006 Dutton RC, Laster MJ, Xing Y, Sonner JM, Raines DE, Solt K, Eger EI
• Naloxone does not increase the minimum alveolar anesthetic concentration of sevoflurane in mice.
  Anesthesia and analgesia 2006 Liao M, Laster MJ, Eger EI, Tang M, Sonner JM
• The minimum alveolar anesthetic concentration of 2-, 3-, and 4-alcohols and ketones in rats: relevance to anesthetic mechanisms.
  Anesthesia and analgesia 2006 Won A, Oh I, Liao M, Sonner JM, Harris RA, Laster MJ, Brosnan R, Trudell JR, Eger EI
• Anaesthesia defined (gentlemen, this is no humbug).
  Best practice & research. Clinical anaesthesiology 2006 Eger EI, Sonner JM
• Hypothermia decreases ethanol MAC in rats.
  Journal of anesthesia 2006 Won A, Oh I, Brosnan R, Eger EI, Sonner JM
• Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane.
  Anesthesia and analgesia 2005 Liao M, Sonner JM, Jurd R, Rudolph U, Borghese CM, Harris RA, Laster MJ, Eger EI
• R (+) etomidate and the photoactivable R (+) azietomidate have comparable anesthetic activity in wild-type mice and comparably decreased activity in mice with a N265M point mutation in the gamma-aminobutyric acid receptor beta3 subunit.
  Anesthesia and analgesia 2005 Liao M, Sonner JM, Husain SS, Miller KW, Jurd R, Rudolph U, Eger EI
• The effect of three inhaled anesthetics in mice harboring mutations in the GluR6 (kainate) receptor gene.
  Anesthesia and analgesia 2005 Sonner JM, Vissel B, Royle G, Maurer A, Gong D, Baron NV, Harrison N, Fanselow M, Eger EI
• Administration of epinephrine does not increase learning of fear to tone in rats anesthetized with isoflurane or desflurane.
  Anesthesia and analgesia 2005 Sonner JM, Xing Y, Zhang Y, Maurer A, Fanselow MS, Dutton RC, Eger EI
• Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear.
  Molecular pharmacology 2005 Sonner JM, Cascio M, Xing Y, Fanselow MS, Kralic JE, Morrow AL, Korpi ER, Hardy S, Sloat B, Eger EI, Homanics GE
• The effect of meperidine on thermoregulation in mice: involvement of alpha2-adrenoceptors.
  Anesthesia and analgesia 2005 Paris A, Ohlendorf C, Marquardt M, Bein B, Sonner JM, Scholz J, Tonner PH
• Thiopental produces immobility primarily by supraspinal actions in rats.
  Anesthesia and analgesia 2005 Stabernack C, Zhang Y, Sonner JM, Laster M, Eger EI
• Mice with a melanocortin 1 receptor mutation have a slightly greater minimum alveolar concentration than control mice.
  Anesthesiology 2004 Xing Y, Sonner JM, Eger EI, Cascio M, Sessler DI
• Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane.
  Anesthesia and analgesia 2004 Zhang Y, Sonner JM, Eger EI, Stabernack CR, Laster MJ, Raines DE, Harris RA
• Women appear to have the same minimum alveolar concentration as men: a retrospective study.
  Anesthesiology 2003 Eger EI, Laster MJ, Gregory GA, Katoh T, Sonner JM
• Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration.
  Anesthesia and analgesia 2003 Sonner JM, Antognini JF, Dutton RC, Flood P, Gray AT, Harris RA, Homanics GE, Kendig J, Orser B, Raines DE, Trudell J, Vissel B, Eger EI
• Blockade of 5-HT2A receptors may mediate or modulate part of the immobility produced by inhaled anesthetics.
  Anesthesia and analgesia 2003 Zhang Y, Laster MJ, Eger EI, Stabernack CR, Sonner JM
• Alpha-2 adrenoreceptors probably do not mediate the immobility produced by inhaled anesthetics.
  Anesthesia and analgesia 2003 Eger EI, Xing Y, Laster MJ, Sonner JM
• Temporal summation governs part of the minimum alveolar concentration of isoflurane anesthesia.
  Anesthesiology 2003 Dutton RC, Zhang Y, Stabernack CR, Laster MJ, Sonner JM, Eger EI
• Halothane and isoflurane have additive minimum alveolar concentration (MAC) effects in rats.
  Anesthesia and analgesia 2003 Eger EI, Xing Y, Laster M, Sonner J, Antognini JF, Carstens E
• Isoflurane antagonizes the capacity of flurothyl or 1,2-dichlorohexafluorocyclobutane to impair fear conditioning to context and tone.
  Anesthesia and analgesia 2003 Eger EI, Xing Y, Pearce R, Shafer S, Laster MJ, Zhang Y, Fanselow MS, Sonner JM
• GABA(A) receptor blockade antagonizes the immobilizing action of propofol but not ketamine or isoflurane in a dose-related manner.
  Anesthesia and analgesia 2003 Bovill JG, Sonner JM, Zhang Y, Stabernack C, Abaigar W, Xing Y, Laster MJ
• Glycine receptors mediate part of the immobility produced by inhaled anesthetics.
  Anesthesia and analgesia 2003 Zhang Y, Laster MJ, Hara K, Harris RA, Eger EI, Stabernack CR, Sonner JM
• Spinal N-methyl-d-aspartate receptors may contribute to the immobilizing action of isoflurane.
  Anesthesia and analgesia 2003 Stabernack C, Sonner JM, Laster M, Zhang Y, Xing Y, Sharma M, Eger EI
• Isoflurane hyperalgesia is modulated by nicotinic inhibition.
  Anesthesiology 2002 Flood P, Sonner JM, Gong D, Coates KM
• Acetylcholine receptors do not mediate isoflurane's actions on spinal cord in vitro.
  Anesthesia and analgesia 2002 Wong SM, Sonner JM, Kendig JJ
• Acetylcholine receptors do not mediate the immobilization produced by inhaled anesthetics.
  Anesthesia and analgesia 2002 Eger EI, Zhang Y, Laster M, Flood P, Kendig JJ, Sonner JM
• Do sevoflurane and desflurane differ in upper airway reactivity?
  Anesthesiology 2002 Sonner J, Fisher DM
• Isoflurane causes anterograde but not retrograde amnesia for pavlovian fear conditioning.
  Anesthesiology 2002 Dutton RC, Maurer AJ, Sonner JM, Fanselow MS, Laster MJ, Eger EI
• Short-term memory resists the depressant effect of the nonimmobilizer 1-2-dichlorohexafluorocyclobutane (2N) more than long-term memory.
  Anesthesia and analgesia 2002 Dutton RC, Maurer AJ, Sonner JM, Fanselow MS, Laster MJ, Eger EI