Jianhang Yin, PhD
Postdoctoral Scholar
Microbiology and Immunology
School of Medicine

Education & Training

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• PhD CRISPR and genome stability Peking University 2022/07
• Bachelor Biology Peking University 2016/07

Grants and Projects

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• , Cancer Research Institute

Publications (12)

Top publication keywords:
Genetic TherapyDNA RepairCRISPR-Associated ProteinsChromosome DeletionEndonucleasesStreptococcus pyogenesMacular DegenerationCRISPR-Cas SystemsCell Cycle ProteinsTranslocation, GeneticGene EditingGene TargetingEndodeoxyribonucleasesDNA Breaks, Double-StrandedOryza

• Cohesin maintains replication timing to suppress DNA damage on cancer genes.
  Nature genetics 2023 Wu J, Liu Y, Zhangding Z, Liu X, Ai C, Gan T, Liang H, Guo Y, Chen M, Liu Y, Yin J, Zhang W, Hu J
• Safeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration.
  Nature communications 2022 Yin J, Fang K, Gao Y, Ou L, Yuan S, Xin C, Wu W, Wu WW, Hong J, Yang H, Hu J
• Comprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption.
  Nature communications 2022 Xin C, Yin J, Yuan S, Ou L, Liu M, Zhang W, Hu J
• The origin of unwanted editing byproducts in gene editing.
  Acta biochimica et biophysica Sinica 2022 Yin J, Hu J
• Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing.
  Nature communications 2022 Yin J, Lu R, Xin C, Wang Y, Ling X, Li D, Zhang W, Liu M, Xie W, Kong L, Si W, Wei P, Xiao B, Lee HY, Liu T, Hu J

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• PEM-seq comprehensively quantifies DNA repair outcomes during gene-editing and DSB repair.
  STAR protocols 2022 Liu Y, Yin J, Gan T, Liu M, Xin C, Zhang W, Hu J
• Improving the efficiency of CRISPR-Cas12a-based genome editing with site-specific covalent Cas12a-crRNA conjugates.
  Molecular cell 2021 Ling X, Chang L, Chen H, Gao X, Yin J, Zuo Y, Huang Y, Zhang B, Hu J, Liu T
• Global detection of DNA repair outcomes induced by CRISPR-Cas9.
  Nucleic acids research 2021 Liu M, Zhang W, Xin C, Yin J, Shang Y, Ai C, Li J, Meng FL, Hu J
• In-depth assessment of the PAM compatibility and editing activities of Cas9 variants.
  Nucleic acids research 2021 Zhang W, Yin J, Zhang-Ding Z, Xin C, Liu M, Wang Y, Ai C, Hu J
• Improved HTGTS for CRISPR/Cas9 off-target detection.
  Bio-protocol 2019 Yin J, Liu M, Liu Y, Hu J
• Optimizing genome editing strategy by primer-extension-mediated sequencing.
  Cell discovery 2019 Yin J, Liu M, Liu Y, Wu J, Gan T, Zhang W, Li Y, Zhou Y, Hu J
• CRISPR/Cas9-mediated targeted chromosome elimination.
  Genome biology 2017 Zuo E, Huo X, Yao X, Hu X, Sun Y, Yin J, He B, Wang X, Shi L, Ping J, Wei Y, Ying W, Wei W, Liu W, Tang C, Li Y, Hu J, Yang H