Jian Shi, PhD
Associate Professor
Neurology
School of Medicine

My research focuses on unraveling the complexities of Alzheimer's disease, brain injuries, and brain tumors. By integrating computational approaches, such as machine learning, with molecular and cellular techniques and animal models, we aim to decode disease mechanisms, identify novel diagnostic biomarkers, and explore new therapeutic targets. Our multidisciplinary work bridges the gap between data-driven discovery and biological experiments to combat these challenging neurological disorders.

Education & Training

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• post-doctor Neuroscience and Developmental Biology UT Southwestern Medical Center 2006

Publications (18)

Top publication keywords:
Biomarkers, TumorMicrogliaBrain NeoplasmsReceptor, Nerve Growth FactorInositol 1,4,5-Trisphosphate ReceptorsAlzheimer DiseaseMicroRNAsbcl-2-Associated X ProteinBrain InjuriesCaspase 3Multipotent Stem CellsGlioblastomaNeuronsCirculating MicroRNAPotassium Channels, Voltage-Gated

• MicroRNAs as Potential Biomarkers for Alzheimer's Disease in Women.
  Genes 2025 Huang S, Zhong L, Zheng L, Shi J
• A Small-Molecule TrkB/TrkC Ligand Promotes Neurogenesis and Behavioral Recovery Following Traumatic Brain Injury.
  Neurotrauma reports 2025 Shi J, Yang T, Li Y, Zhong L, Longo FM, Massa SM
• Early 2-Factor Transcription Factors Associated with Progression and Recurrence in Bevacizumab-Responsive Subtypes of Glioblastoma.
  Cancers 2024 Shi J
• Blood Markers Show Neural Consequences of LongCOVID-19.
  Cells 2024 Tang N, Kido T, Shi J, McCafferty E, Ford JM, Dal Bon K, Pulliam L
• Comparative Insight into Microglia/Macrophages-Associated Pathways in Glioblastoma and Alzheimer's Disease.
  International journal of molecular sciences 2023 Shi J, Huang S

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• Sexual dimorphism in immune cell responses following stroke.
  Neurobiology of disease 2022 Liu J, Sato Y, Falcone-Juengert J, Kurisu K, Shi J, Yenari MA
• Machine learning and bioinformatics approaches for classification and clinical detection of bevacizumab responsive glioblastoma subtypes based on miRNA expression.
  Scientific reports 2022 Shi J
• Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2018 Kurisu K, Zheng Z, Kim JY, Shi J, Kanoke A, Liu J, Hsieh CL, Yenari MA
• MicroRNAs as biomarkers for human glioblastoma: progress and potential.
  Acta pharmacologica Sinica 2018 Huang SW, Ali ND, Zhong L, Shi J
• Considering Exosomal miR-21 as a Biomarker for Cancer.
  Journal of clinical medicine 2016 Shi J
• A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury.
  Stem cells (Dayton, Ohio) 2013 Shi J, Longo FM, Massa SM
• Beneficial effects of minocycline and botulinum toxin-induced constraint physical therapy following experimental traumatic brain injury.
  Neurorehabilitation and neural repair 2013 Lam TI, Bingham D, Chang TJ, Lee CC, Shi J, Wang D, Massa S, Swanson RA, Liu J
• Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor.
  Journal of neuroinflammation 2012 d'Avila JC, Lam TI, Bingham D, Shi J, Won SJ, Kauppinen TM, Massa S, Liu J, Swanson RA
• Efficacy of reductive ventricular osmotherapy in a swine model of traumatic brain injury.
  Neurosurgery 2012 Odland RM, Venugopal S, Borgos J, Coppes V, McKinney AM, Rockswold G, Shi J, Panter S
• Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.
  The Journal of clinical investigation 2010 Massa SM, Yang T, Xie Y, Shi J, Bilgen M, Joyce JN, Nehama D, Rajadas J, Longo FM
• The basic helix-loop-helix transcription factor olig2 is critical for reactive astrocyte proliferation after cortical injury.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Chen Y, Miles DK, Hoang T, Shi J, Hurlock E, Kernie SG, Lu QR
• Injury-induced neurogenesis in Bax-deficient mice: evidence for regulation by voltage-gated potassium channels.
  The European journal of neuroscience 2007 Shi J, Miles DK, Orr BA, Massa SM, Kernie SG
• Bax limits adult neural stem cell persistence through caspase and IP3 receptor activation.
  Cell death and differentiation 2005 Shi J, Parada LF, Kernie SG