Jialing Liu, PhD
Professor
Neurological Surgery
School of Medicine

Education & Training

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• PhD/Immunology School of Medicine Boston University Medical Center
• Postdoctoral Studies Graduate Division University of California, San Francisco

Websites

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• Profile at UCSF Department of Neurological Surgery (neurosurgery.ucsf.edu)
• Profile BMS (bms.ucsf.edu)

Grants and Projects

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• Collateral flow and stroke outcome, NIH, 2016-2025
• BLR&D Research Career Scientist Award Application, NIH, 2019-2024
• Analysis of stroke-induced changes in connectivity and neural activity, NIH, 2021-2023
• Stroke in females with metabolic syndrome, a vascular perspective, NIH, 2018-2023
• ShEEP request for High Performance Electrophysiological System for Recording and Closed-Loop Stimulation, NIH, 2019-2020
• Neuroplasticity after experimental stroke, NIH, 2011-2017
• Mechanisms underlying Netrin-1-mediated functional recovery after stroke, NIH, 2012-2016
• Proteomics study of neurogenesis signaling after stroke, NIH, 2005-2009
• Neural stem cell and brain plasticity after stroke, NIH, 2001-2007

Publications (76)

Top publication keywords:
CD36 AntigensStrokeHippocampusCollateral CirculationCircle of WillisNeurogenesisLipoproteins, LDLBrain IschemiaMeningesBrain WavesCerebral Arterial DiseasesBrain InjuriesCerebral InfarctionMinocyclineCerebrovascular Circulation

• Vascular Dysfunctions Contribute to the Long-Term Cognitive Deficits Following COVID-19.
  Biology 2023 Zahra Shabani, Jialing Liu, Hua Su
• Type-2 Diabetes Alters Hippocampal Neural Oscillations and Disrupts Synchrony between the Hippocampus and Cortex.
  Aging and Disease 2023 Gratianne Rabiller, Zachary Ip, Shahram Zarrabian, Hongxia Zhang, Yoshimichi Sato, Azadeh Yazdan-Shahmorad, Jialing Liu
• Remodeling of the Neurovascular Unit Following Cerebral Ischemia and Hemorrhage.
  Cells 2022 Sato Y, Falcone-Juengert J, Tominaga T, Su H, Liu J
• Sexual dimorphism in immune cell responses following stroke.
  Neurobiology of disease 2022 Liu J, Sato Y, Falcone-Juengert J, Kurisu K, Shi J, Yenari MA
• Pathological changes of brain oscillations following ischemic stroke.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2022 Sato Y, Schmitt O, Ip Z, Rabiller G, Omodaka S, Tominaga T, Yazdan-Shahmorad A, Liu J

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• Abstract TP242: The Suppression Of Leukocyte Rolling Via Blocking P-selectin After Stroke Is Not Sustained In Mice With Type 2 Diabetes.
  Stroke 2022 yoshimichi sato, SuWai Wong, Gratianne Rabiller, Jialing Liu
• Abstract WP234: Age And Type 2 Diabetes Reduce The Coherence Of Theta And Gamma Oscillations Between Brain Networks.
  Stroke 2022 Gratianne Rabiller, yoshimichi sato, SuWai Wong, Zachary Ip, Azadeh Yazdan-shahmorad, Jialing Liu
• Local field potentials identify features of cortico-hippocampal communication impacted by stroke and environmental enrichment therapy.
  Journal of neural engineering 2021 Ip Z, Rabiller G, He JW, Chavan S, Nishijima Y, Akamatsu Y, Liu J, Yazdan-Shahmorad A
• The effect of type 2 diabetes on CD36 expression and the uptake of oxLDL: Diabetes affects CD36 and oxLDL uptake.
  Experimental neurology 2020 Kanoke A, Nishijima Y, Ljungberg M, Omodaka S, Yang SY, Wong S, Rabiller G, Tominaga T, Hsieh CL, Liu J
• The impact of native leptomeningeal collateralization on rapid blood flow recruitment following ischemic stroke.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2020 Kanoke A, Akamatsu Y, Nishijima Y, To E, Lee CC, Li Y, Wang RK, Tominaga T, Liu J
• Experimental cortical stroke induces aberrant increase of sharp-wave-associated ripples in the hippocampus and disrupts cortico-hippocampal communication.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2019 He JW, Rabiller G, Nishijima Y, Akamatsu Y, Khateeb K, Yazdan-Shahmorad A, Liu J
• Cortical stroke affects activity and stability of theta/delta states in remote hippocampal regions.
  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2019 Ip Z, Rabiller G, He JW, Yao Z, Akamatsu Y, Nishijima Y, Liu J, Yazdan-Shahmorad A
• Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2018 Kurisu K, Zheng Z, Kim JY, Shi J, Kanoke A, Liu J, Hsieh CL, Yenari MA
• Aging-associated changes in cerebral vasculature and blood flow as determined by quantitative optical coherence tomography angiography.
  Neurobiology of aging 2018 Li Y, Choi WJ, Wei W, Song S, Zhang Q, Liu J, Wang RK
• Prediction of regional functional impairment following experimental stroke via connectome analysis.
  Scientific reports 2017 Schmitt O, Badurek S, Liu W, Wang Y, Rabiller G, Kanoke A, Eipert P, Liu J
• A data-driven approach for evaluating multi-modal therapy in traumatic brain injury.
  Scientific reports 2017 Haefeli J, Ferguson AR, Bingham D, Orr A, Won SJ, Lam TI, Shi J, Hawley S, Liu J, Swanson RA, Massa SM
• Chapter 19 Vascular Remodeling After Cerebral Ischemia.
  2017 Y. Nishijima, Y. Akamatsu, K. Masamoto, J. Liu
• Impaired Collateral Flow Compensation During Chronic Cerebral Hypoperfusion in the Type 2 Diabetic Mice.
  Stroke 2016 Nishijima Y, Akamatsu Y, Yang SY, Lee CC, Baran U, Song S, Wang RK, Tominaga T, Liu J
• Deciphering the Role of Emx1 in Neurogenesis: A Neuroproteomics Approach.
  Frontiers in molecular neuroscience 2016 Kobeissy FH, Hansen K, Neumann M, Fu S, Jin K, Liu J
• Training of the impaired forelimb after traumatic brain injury enhances hippocampal neurogenesis in the Emx1 null mice lacking a corpus callosum.
  Behavioural brain research 2016 Neumann M, Liu W, Sun C, Yang SY, Noble-Haeusslein LJ, Liu J
• Abstract WP279: Disruption of Cortico-hippocampal Functional Connectivity Underlies the Memory Impairment Following Experimental Stroke.
  Stroke 2016 Gratianne Rabiller, Yasuo Nishijima, Jiwei He, Xavier Leinekugel, Bruno Bontempi, Jialing Liu
• Perturbation of Brain Oscillations after Ischemic Stroke: A Potential Biomarker for Post-Stroke Function and Therapy.
  International journal of molecular sciences 2015 Rabiller G, He JW, Nishijima Y, Wong A, Liu J
• Poststroke angiogenesis: blood, bloom, or brood?
  Stroke 2015 Liu J
• Collaterals: Implications in cerebral ischemic diseases and therapeutic interventions.
  Brain research 2015 Nishijima Y, Akamatsu Y, Weinstein PR, Liu J
• Impaired leptomeningeal collateral flow contributes to the poor outcome following experimental stroke in the Type 2 diabetic mice.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Akamatsu Y, Nishijima Y, Lee CC, Yang SY, Shi L, An L, Wang RK, Tominaga T, Liu J
• Abstract W P263: Alteration In Hippocampal Oscillations After Stroke: A Candidate Biomarker For Stroke-induced Cognitive Impairment.
  Stroke 2015 Ji-Wei He, Yasuo Nishijima, Yosuke Akamatsu, Gratianne Rabiller, Jialing Liu
• Calcium-sensing receptor (CaSR) as a novel target for ischemic neuroprotection.
  Annals of clinical and translational neurology 2014 Kim JY, Ho H, Kim N, Liu J, Tu CL, Yenari MA, Chang W
• CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury.
  Journal of neurotrauma 2014 Hsieh CL, Niemi EC, Wang SH, Lee CC, Bingham D, Zhang J, Cozen ML, Charo I, Huang EJ, Liu J, Nakamura MC
• LOX-1 and neurodegeneration.
  Neuroscience letters 2014 Liu J
• Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials.
  Progress in neurobiology 2013 Liu J, Wang Y, Akamatsu Y, Lee CC, Stetler RA, Lawton MT, Yang GY
• Conditional ablation of neuroprogenitor cells in adult mice impedes recovery of poststroke cognitive function and reduces synaptic connectivity in the perforant pathway.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Sun C, Sun H, Wu S, Lee CC, Akamatsu Y, Wang RK, Kernie SG, Liu J
• Beneficial effects of minocycline and botulinum toxin-induced constraint physical therapy following experimental traumatic brain injury.
  Neurorehabilitation and neural repair 2013 Lam TI, Bingham D, Chang TJ, Lee CC, Shi J, Wang D, Massa S, Swanson RA, Liu J
• Traumatic brain injury induces macrophage subsets in the brain.
  European journal of immunology 2013 Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE
• Neuroprotection after cerebral ischemia.
  Annals of the New York Academy of Sciences 2013 Namura S, Ooboshi H, Liu J, Yenari MA
• Prevention of hypoglycemia-induced neuronal death by minocycline.
  Journal of neuroinflammation 2012 Won SJ, Kim JH, Yoo BH, Sohn M, Kauppinen TM, Park MS, Kwon HJ, Liu J, Suh SW
• Recurrent/moderate hypoglycemia induces hippocampal dendritic injury, microglial activation, and cognitive impairment in diabetic rats.
  Journal of neuroinflammation 2012 Won SJ, Yoo BH, Kauppinen TM, Choi BY, Kim JH, Jang BG, Lee MW, Sohn M, Liu J, Swanson RA, Suh SW
• Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor.
  Journal of neuroinflammation 2012 d'Avila JC, Lam TI, Bingham D, Shi J, Won SJ, Kauppinen TM, Massa S, Liu J, Swanson RA
• AAV-mediated netrin-1 overexpression increases peri-infarct blood vessel density and improves motor function recovery after experimental stroke.
  Neurobiology of disease 2011 Sun H, Le T, Chang TT, Habib A, Wu S, Shen F, Young WL, Su H, Liu J
• Environmental Enrichment Preserves Cortical Inputs to the Parahippocampal Areas and Reduces Post Stroke Diaschisis.
  American Journal of Neuroprotection and Neuroregeneration 2011 Yonggang Wang, Bruno Bontempi, Xavier Leinekugel, Edith Lesburguères, Wei Liu, Philip R. Weinstein, Jizong Zhao, Gary M. Abrams, Jialing Liu
• Fluoxetine increases hippocampal neurogenesis and induces epigenetic factors but does not improve functional recovery after traumatic brain injury.
  Journal of neurotrauma 2011 Wang Y, Neumann M, Hansen K, Hong SM, Kim S, Noble-Haeusslein LJ, Liu J
• Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009 Suh SW, Won SJ, Hamby AM, Yoo BH, Fan Y, Sheline CT, Tamano H, Takeda A, Liu J
• Assessing gait impairment following experimental traumatic brain injury in mice.
  Journal of neuroscience methods 2008 Neumann M, Wang Y, Kim S, Hong SM, Jeng L, Bilgen M, Liu J
• A comprehensive analysis of gait impairment after experimental stroke and the therapeutic effect of environmental enrichment in rats.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008 Wang Y, Bontempi B, Hong SM, Mehta K, Weinstein PR, Abrams GM, Liu J
• Microemboli composed of cholesterol crystals disrupt the blood-brain barrier and reduce cognition.
  Stroke 2008 Rapp JH, Pan XM, Neumann M, Hong M, Hollenbeck K, Liu J
• Erythropoietin promotes neuronal replacement through revascularization and neurogenesis after neonatal hypoxia/ischemia in rats.
  Stroke 2007 Iwai M, Cao G, Yin W, Stetler RA, Liu J, Chen J
• Reduced hippocampal neurogenesis and skill reaching performance in adult Emx1 mutant mice.
  Experimental neurology 2007 Hong SM, Liu Z, Fan Y, Neumann M, Won SJ, Lac D, Lum X, Weinstein PR, Liu J
• Environmental enrichment enhances neurogenesis and improves functional outcome after cranial irradiation.
  The European journal of neuroscience 2007 Fan Y, Liu Z, Weinstein PR, Fike JR, Liu J
• Chronic treatment with minocycline preserves adult new neurons and reduces functional impairment after focal cerebral ischemia.
  Stroke 2006 Liu Z, Fan Y, Won SJ, Neumann M, Hu D, Zhou L, Weinstein PR, Liu J
• Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70.
  Stroke 2006 Matsumori Y, Northington FJ, Hong SM, Kayama T, Sheldon RA, Vexler ZS, Ferriero DM, Weinstein PR, Liu J
• Enriched environment and spatial learning enhance hippocampal neurogenesis and salvages ischemic penumbra after focal cerebral ischemia.
  Neurobiology of disease 2005 Matsumori Y, Hong SM, Fan Y, Kayama T, Hsu CY, Weinstein PR, Liu J
• Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse.
  Nature neuroscience 2005 Aoyama K, Suh SW, Hamby AM, Liu J, Chan WY, Chen Y, Swanson RA
• Antiapoptotic and Anti-inflammatory Mechanisms of Heat-Shock Protein Protection.
  Annals of the New York Academy of Sciences 2005 MIDORI A. YENARI, JIALING LIU, ZHEN ZHENG, ZINAIDA S. VEXLER, JONG EUN LEE, RONA G. GIFFARD
• Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection.
  Annals of the New York Academy of Sciences 2005 Yenari MA, Liu J, Zheng Z, Vexler ZS, Lee JE, Giffard RG
• Enriched environment and learning enhances neurogenesis and peri-infarct neuronal density after cerebral focal ischemia.
  Journal of Cerebral Blood Flow & Metabolism 2005 Yasuhiko Matsumori, Shwuhuey M Hong, Yang Fan, Zhengyan Liu, Philip R Weinstein, Chung Y Hsu, Jialing Liu
• Minocycline enhances neurogenesis and functional recovery after stroke injury.
  Journal of Cerebral Blood Flow & Metabolism 2005 Zhengyan Liu, Yang Fan, Shwuhuey M Hong, Jialing Liu
• Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005 Matsumori Y, Hong SM, Aoyama K, Fan Y, Kayama T, Sheldon RA, Vexler ZS, Ferriero DM, Weinstein PR, Liu J
• Pyruvate administered after severe hypoglycemia reduces neuronal death and cognitive impairment.
  Diabetes 2005 Suh SW, Aoyama K, Matsumori Y, Liu J, Swanson RA
• Hypoglycemia induces transient neurogenesis and subsequent progenitor cell loss in the rat hippocampus.
  Diabetes 2005 Suh SW, Fan Y, Hong SM, Liu Z, Matsumori Y, Weinstein PR, Swanson RA, Liu J
• Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues.
  Nature biotechnology 2004 Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA
• Irradiation attenuates neurogenesis and exacerbates ischemia-induced deficits.
  Annals of neurology 2004 Raber J, Fan Y, Matsumori Y, Liu Z, Weinstein PR, Fike JR, Liu J
• Human serum albumin and its N-terminal tetrapeptide (DAHK) block oxidant-induced neuronal death.
  Stroke 2004 Gum ET, Swanson RA, Alano C, Liu J, Hong S, Weinstein PR, Panter SS
• Hypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 Suh SW, Aoyama K, Chen Y, Garnier P, Matsumori Y, Gum E, Liu J, Swanson RA
• Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures.
  Neurosurgery 2003 Tsuchiya D, Hong S, Matsumori Y, Kayama T, Swanson RA, Dillman WH, Liu J, Panter SS, Weinstein PR
• Differential cerebral protein synthesis and heat shock protein 70 expression in the core and penumbra of rat brain after transient focal ischemia.
  Neurosurgery 2003 Kokubo Y, Liu J, Rajdev S, Kayama T, Sharp FR, Weinstein PR
• Overexpression of rat heat shock protein 70 is associated with reduction of early mitochondrial cytochrome C release and subsequent DNA fragmentation after permanent focal ischemia.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003 Tsuchiya D, Hong S, Matsumori Y, Shiina H, Kayama T, Swanson RA, Dillman WH, Liu J, Panter SS, Weinstein PR
• Correlation between changes in apparent diffusion coefficient and induction of heat shock protein, cell-specific injury marker expression, and protein synthesis reduction on diffusion-weighted magnetic resonance images after temporary focal cerebral ischemia in rats.
  Journal of neurosurgery 2002 Kokubo Y, Matson GB, Liu J, Mancuso A, Kayama T, Sharp FR, Weinstein PR
• Microglia/macrophages proliferate in striatum and neocortex but not in hippocampus after brief global ischemia that produces ischemic tolerance in gerbil brain.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001 Liu J, Bartels M, Lu A, Sharp FR
• Neurogenesis and Gliogenesis in the Postischemic Brain.
  The Neuroscientist 2000 Jialing Liu, Ramon Bernabeu, Aigang Lu, Frank R. Sharp
• Effects of transient global ischemia and kainate on poly(ADP-ribose) polymerase (PARP) gene expression and proteolytic cleavage in gerbil and rat brains.
  Brain research. Molecular brain research 2000 Liu J, Ying W, Massa S, Duriez PJ, Swanson RA, Poirier GG, Sharp FR
• Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 Liu J, Solway K, Messing RO, Sharp FR
• Neuronal regulation of glutamate transporter subtype expression in astrocytes.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1997 Swanson RA, Liu J, Miller JW, Rothstein JD, Farrell K, Stein BA, Longuemare MC
• Morphine induces c-fos and junB in striatum and nucleus accumbens via D1 and N-methyl-D-aspartate receptors.
  Proceedings of the National Academy of Sciences of the United States of America 1994 Liu J, Nickolenko J, Sharp FR
• Cyclosporin-A sensitive induction of NF-AT in murine B cells.
  Immunity 1994 Venkataraman L, Francis DA, Wang Z, Liu J, Rothstein TL, Sen R
• Abnormal kappa B-binding protein in the cytoplasm of a plasmacytoma cell line that lacks nuclear expression of NF-kappa B.
  Molecular immunology 1993 Liu J, Sen R, Rothstein TL
• Cross-linking of surface Ig receptors on murine B lymphocytes stimulates the expression of nuclear tetradecanoyl phorbol acetate-response element-binding proteins.
  Journal of immunology (Baltimore, Md. : 1950) 1991 Chiles TC, Liu JL, Rothstein TL
• Inducible nuclear expression of NF-kappa B in primary B cells stimulated through the surface Ig receptor.
  Journal of immunology (Baltimore, Md. : 1950) 1991 Liu JL, Chiles TC, Sen RJ, Rothstein TL