Jessie Turnbaugh, PhD
Full Specialist
Hooper Foundation
School of Medicine

Education & Training

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• PhD Molecular Cell Biology Washington University in St. Louis 2011

Websites

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• Gnotobiotic Core Facility (gnotobiotics.ucsf.edu)

Publications (16)

Top publication keywords:
BacteriaOperonPeptide FragmentsLymphotoxin-alphaPrPSc ProteinsTumor Necrosis Factor alpha-Induced Protein 3PrionsUbiquitinDiet, KetogenicGastrointestinal MicrobiomePrion DiseasesPrPC ProteinsEnteritisTh17 CellsInterleukins

• A20's linear ubiquitin-binding motif restrains pathogenic activation of Th17 cells and IL-22-driven enteritis.
  The Journal of clinical investigation 2025 Bowman CJ, Stibor DM, Sun X, Lenci N, Shimizu H, Yamashita EF, Advincula R, Kim MC, Turnbaugh JA, Sun Y, Razani B, Turnbaugh PJ, Ye CJ, Malynn BA, Ma A
• Expansion of a bacterial operon during cancer treatment ameliorates fluoropyrimidine toxicity.
  Science translational medicine 2025 Trepka KR, Kidder WA, Kyaw TS, Halsey T, Olson CA, Ortega EF, Noecker C, Upadhyay V, Stanfield D, Steiding P, Guthrie BGH, Spanogiannopoulos P, Dumlao D, Turnbaugh JA, Stachler MD, Van Blarigan EL, …
• A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity.
  Cell reports 2024 Alexander M, Upadhyay V, Rock R, Ramirez L, Trepka K, Puchalska P, Orellana D, Ang QY, Whitty C, Turnbaugh JA, Tian Y, Dumlao D, Nayak R, Patterson A, Newman JC, Crawford PA, Turnbaugh PJ
• Expansion of a bacterial operon during cancer treatment ameliorates drug toxicity.
  bioRxiv : the preprint server for biology 2024 Trepka KR, Kidder WA, Kyaw TS, Halsey T, Olson CA, Ortega EF, Noecker C, Upadhyay V, Stanfield D, Steiding P, Guthrie BGH, Spanogiannopoulos P, Dumlao D, Turnbaugh JA, Stachler MD, Van Blarigan EL, …
• A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity.
  bioRxiv : the preprint server for biology 2024 Alexander M, Upadhyay V, Rock R, Ramirez L, Trepka K, Puchalska P, Orellana D, Ang QY, Whitty C, Turnbaugh JA, Tian Y, Dumlao D, Nayak R, Patterson A, Newman JC, Crawford PA, Turnbaugh PJ

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• Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage.
  The Journal of clinical investigation 2022 Rusu I, Mennillo E, Bain JL, Li Z, Sun X, Ly KM, Rosli YY, Naser M, Wang Z, Advincula R, Achacoso P, Shao L, Razani B, Klein OD, Marson A, Turnbaugh JA, Turnbaugh PJ, Malynn BA, Ma A, Kattah MG
• Caloric restriction disrupts the microbiota and colonization resistance.
  Nature 2021 von Schwartzenberg RJ, Bisanz JE, Lyalina S, Spanogiannopoulos P, Ang QY, Cai J, Dickmann S, Friedrich M, Liu SY, Collins SL, Ingebrigtsen D, Miller S, Turnbaugh JA, Patterson AD, Pollard KS, Mai K, …
• Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells.
  Cell 2020 Ang QY, Alexander M, Newman JC, Tian Y, Cai J, Upadhyay V, Turnbaugh JA, Verdin E, Hall KD, Leibel RL, Ravussin E, Rosenbaum M, Patterson AD, Turnbaugh PJ
• Non-catalytic ubiquitin binding by A20 prevents psoriatic arthritis-like disease and inflammation.
  Nature immunology 2020 Razani B, Whang MI, Kim FS, Nakamura MC, Sun X, Advincula R, Turnbaugh JA, Pendse M, Tanbun P, Achacoso P, Turnbaugh PJ, Malynn BA, Ma A
• Meta-Analysis Reveals Reproducible Gut Microbiome Alterations in Response to a High-Fat Diet.
  Cell host & microbe 2019 Bisanz JE, Upadhyay V, Turnbaugh JA, Ly K, Turnbaugh PJ
• The N-terminal, polybasic region of PrP(C) dictates the efficiency of prion propagation by binding to PrP(Sc).
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Turnbaugh JA, Unterberger U, Saá P, Massignan T, Fluharty BR, Bowman FP, Miller MB, Supattapone S, Biasini E, Harris DA
• The toxicity of a mutant prion protein is cell-autonomous, and can be suppressed by wild-type prion protein on adjacent cells.
  PloS one 2012 Biasini E, Turnbaugh JA, Massignan T, Veglianese P, Forloni G, Bonetto V, Chiesa R, Harris DA
• Prion protein at the crossroads of physiology and disease.
  Trends in neurosciences 2011 Biasini E, Turnbaugh JA, Unterberger U, Harris DA
• A naturally occurring C-terminal fragment of the prion protein (PrP) delays disease and acts as a dominant-negative inhibitor of PrPSc formation.
  The Journal of biological chemistry 2011 Westergard L, Turnbaugh JA, Harris DA
• The N-terminal, polybasic region is critical for prion protein neuroprotective activity.
  PloS one 2011 Turnbaugh JA, Westergard L, Unterberger U, Biasini E, Harris DA
• A nine amino acid domain is essential for mutant prion protein toxicity.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Westergard L, Turnbaugh JA, Harris DA