Jessica Van Ziffle, PhD
Associate Professor
Pathology
School of Medicine

Publications (47)

Top publication keywords:
Receptor, Platelet-Derived Growth Factor alphaSequence DeletionProtein-Tyrosine KinasesLeukemia, Myelomonocytic, JuvenileGliomaHydrops FetalisHomozygoteBrain NeoplasmsLateral VentriclesAstrocytomaReceptors, OdorantNeoplasms, NeuroepithelialIntracellular Signaling Peptides and Proteinsbeta-ThalassemiaTumor Necrosis Factor Receptor-Associated Peptides and Proteins

• Efficacy of the ATR inhibitor ceralasertib in patients with ARID1A-deficient gynecologic and other solid tumor malignancies.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2026 Zhu X, Alvarez EA, Umetsu SE, Chapman JS, Chen LM, Ueda S, Henderson S, Nguyen P, Calabrese S, Russell J, Aguilar J, Smith SA, Shah N, Feeney L, Van Ziffle J, Turski ML, Ko AH, Munster PN, Ashworth A,…
• Insights Into Congenital Lymphatic Anomalies Underlying Fetal Effusions.
  Prenatal diagnosis 2025 Vargo SG, Rogerson D, Devine P, Van Ziffle J, Sparks TN
• Genetic diseases underlying a spectrum of fetal effusions.
  American journal of obstetrics and gynecology 2025 Gulrajani NB, Lianoglou BR, Tick K, Sahin-Hodoglugil NN, Hodoglugil U, Devine P, Van Ziffle J, Norton ME, Sparks TN
• Clinical implementation of preemptive pharmacogenomics testing for personalized medicine at an academic medical center.
  Journal of the American Medical Informatics Association : JAMIA 2025 Tamraz B, Shin J, Khanna R, Van Ziffle J, Knowles S, Stregowski S, Wan E, Kamath R, Collins C, Phunsur C, Tsai B, Kong P, Calanoc C, Pollard A, Sawhney R, Pleiman J, Devine WP, Croci R, Sashikanth A, …
• Next-generation sequencing has diagnostic utility in challenging small/flat urothelial lesions.
  Annals of diagnostic pathology 2024 Pinard A, Chen C, Van Ziffle J, Simko JP, Stohr BA, Chan E

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• Clinicopathologic and molecular features of intracranial desmoplastic small round cell tumors.
  Brain pathology (Zurich, Switzerland) 2019 Lee JC, Villanueva-Meyer JE, Ferris SP, Cham EM, Zucker J, Cooney T, Gilani A, Kleinschmidt-DeMasters BK, Trembath D, Mafra M, Chiang J, Ellison DW, Cho SJ, Horvai AE, Van Ziffle J, Onodera C, Devine …
• A novel truncating variant in ring finger protein 113A (RNF113A) confirms the association of this gene with X-linked trichothiodystrophy.
  American journal of medical genetics. Part A 2019 Mendelsohn BA, Beleford DT, Abu-El-Haija A, Alsaleh NS, Rahbeeni Z, Martin PM, Rego S, Huang A, Capodanno G, Shieh JT, Van Ziffle J, Risch N, Alkuraya FS, Slavotinek AM
• Myxoid glioneuronal tumor, PDGFRA p.K385-mutant: clinical, radiologic, and histopathologic features.
  Brain pathology (Zurich, Switzerland) 2019 Lucas CG, Villanueva-Meyer JE, Whipple N, Oberheim Bush NA, Cooney T, Chang S, McDermott M, Berger M, Cham E, Sun PP, Putnam A, Zhou H, Bollo R, Cheshier S, Poppe MM, Fung KM, Sung S, Glenn C, Fan X, …
• Fusion driven JMML: a novel CCDC88C-FLT3 fusion responsive to sorafenib identified by RNA sequencing.
  Leukemia 2019 Chao AK, Meyer JA, Lee AG, Hecht A, Tarver T, Van Ziffle J, Koegel AK, Golden C, Braun BS, Sweet-Cordero EA, Smith CC, Dvorak CC, Loh ML, Stieglitz E
• Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas.
  Acta neuropathologica 2019 Sloan EA, Cooney T, Oberheim Bush NA, Buerki R, Taylor J, Clarke JL, Torkildson J, Kline C, Reddy A, Mueller S, Banerjee A, Butowski N, Chang S, Mummaneni PV, Chou D, Tan L, Theodosopoulos P, …
• Hormone receptor expression of colorectal cancer diagnosed during the peri-partum period.
  Endocrine connections 2019 Silverstein J, Kidder W, Fisher S, Hope TA, Maisel S, Ng D, Van Ziffle J, Atreya CE, Van Loon K
• TP53 structural variants in metastatic prostatic carcinoma.
  PloS one 2019 Sirohi D, Devine P, Grenert JP, van Ziffle J, Simko JP, Stohr BA
• High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis.
  Brain pathology (Zurich, Switzerland) 2019 Ferris SP, Velazquez Vega J, Aboian M, Lee JC, Van Ziffle J, Onodera C, Grenert JP, Saunders T, Chen YY, Banerjee A, Kline CN, Gupta N, Raffel C, Samuel D, Ruiz-Diaz I, Magaki S, Wilson D, Neltner J, …
• Primary intracranial sarcomas with DICER1 mutation often contain prominent eosinophilic cytoplasmic globules and can occur in the setting of neurofibromatosis type 1.
  Acta neuropathologica 2019 Lee JC, Villanueva-Meyer JE, Ferris SP, Sloan EA, Hofmann JW, Hattab EM, Williams BJ, Guo H, Torkildson J, Florez A, Van Ziffle J, Onodera C, Grenert JP, Cho SJ, Horvai AE, Jones DTW, Pfister SM, …
• CRTC1-MAML2 fusion in mucoepidermoid carcinoma of the breast.
  Histopathology 2018 Bean GR, Krings G, Otis CN, Solomon DA, García JJ, van Zante A, Camelo-Piragua S, van Ziffle J, Chen YY
• The genetic landscape of anaplastic pleomorphic xanthoastrocytoma.
  Brain pathology (Zurich, Switzerland) 2018 Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Bastian BC, Grenert JP, Kline CN, Mueller S, Banerjee A, Nicolaides T, Gupta N, Berger MS, Lee HS, Pekmezci M, Tihan T, Bollen AW, Perry A, Shieh …
• Oligodendrogliomas, IDH-mutant and 1p/19q-codeleted, arising during teenage years often lack TERT promoter mutation that is typical of their adult counterparts.
  Acta neuropathologica communications 2018 Lee J, Putnam AR, Chesier SH, Banerjee A, Raffel C, Van Ziffle J, Onodera C, Grenert JP, Bastian BC, Perry A, Solomon DA
• The genetic landscape of gliomas arising after therapeutic radiation.
  Acta neuropathologica 2018 López GY, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Clarke J, Oberheim Bush NA, Taylor J, Chang S, Butowski N, Banerjee A, Mueller S, Kline C, Torkildson J, Samuel D, Siongco A, Raffel C…
• Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2018 Stevers M, Rabban JT, Garg K, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Zaloudek C, Solomon DA
• Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile.
  Acta neuropathologica 2018 Solomon DA, Korshunov A, Sill M, Jones DTW, Kool M, Pfister SM, Fan X, Bannykh S, Hu J, Danielpour M, Li R, Johnston J, Cham E, Cooney T, Sun PP, Oberheim Bush NA, McDermott M, Van Ziffle J, Onodera C…
• The genetic landscape of ganglioglioma.
  Acta neuropathologica communications 2018 Pekmezci M, Villanueva-Meyer JE, Goode B, Van Ziffle J, Onodera C, Grenert JP, Bastian BC, Chamyan G, Maher OM, Khatib Z, Kleinschmidt-DeMasters BK, Samuel D, Mueller S, Banerjee A, Clarke JL, Cooney …
• A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle.
  Nature communications 2018 Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes…
• Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation.
  Acta neuropathologica 2018 Iorgulescu JB, Van Ziffle J, Stevers M, Grenert JP, Bastian BC, Chavez L, Stichel D, Buchhalter I, Samuel D, Nicolaides T, Banerjee A, Mueller S, Gupta N, Tihan T, Bollen AW, Northcott PA, Kool M, …
• Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway.
  Acta neuropathologica 2018 Pekmezci M, Stevers M, Phillips JJ, Van Ziffle J, Bastian BC, Tsankova NM, Kleinschmidt-DeMasters BK, Rosenblum MK, Tihan T, Perry A, Solomon DA
• Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2017 Goode B, Joseph NM, Stevers M, Van Ziffle J, Onodera C, Talevich E, Grenert JP, Yeh I, Bastian BC, Phillips JJ, Garg K, Rabban JT, Zaloudek C, Solomon DA
• Angiocentric glioma with MYB-QKI fusion located in the brainstem, rather than cerebral cortex.
  Acta neuropathologica 2017 Chan E, Bollen AW, Sirohi D, Van Ziffle J, Grenert JP, Kline CN, Tihan T, Perry A, Gupta N, Solomon DA
• Acute myeloid leukemia with t(14;21) involving RUNX1 and SYNE2: A novel favorable-risk translocation?
  Cancer genetics 2017 Foley N, Van Ziffle J, Yu J, Qi Z, Grenert JP, Yeh I, Bastian B, Kogan S, Mannis GN
• Pierpont syndrome associated with the p.Tyr446Cys missense mutation in TBL1XR1.
  European journal of medical genetics 2017 Slavotinek A, Pua H, Hodoglugil U, Abadie J, Shieh J, Van Ziffle J, Kvale M, Lee H, Kwok PY, Risch N, Sabbadini M
• Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy.
  Neuro-oncology 2017 Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, …
• Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation.
  Acta neuropathologica 2016 Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Jin LW, Bastian BC, Bollen AW, Perry A, Nicolaides T, Solomon DA, Shieh JT
• Genomic profiling of malignant phyllodes tumors reveals aberrations in FGFR1 and PI-3 kinase/RAS signaling pathways and provides insights into intratumoral heterogeneity.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2016 Liu SY, Joseph NM, Ravindranathan A, Stohr BA, Greenland NY, Vohra P, Hosfield E, Yeh I, Talevich E, Onodera C, Van Ziffle JA, Grenert JP, Bastian BC, Chen YY, Krings G
• Constitutional MLH1 methylation presenting with colonic polyposis syndrome and not Lynch syndrome.
  Familial cancer 2016 Kidambi TD, Blanco A, Van Ziffle J, Terdiman JP
• Inactivating MUTYH germline mutations in pediatric patients with high-grade midline gliomas.
  Neuro-oncology 2016 Kline CN, Joseph NM, Grenert JP, van Ziffle J, Yeh I, Bastian BC, Mueller S, Solomon DA
• KRAS insertion mutations are oncogenic and exhibit distinct functional properties.
  Nature communications 2016 White Y, Bagchi A, Van Ziffle J, Inguva A, Bollag G, Zhang C, Carias H, Dickens D, Loh M, Shannon K, Firestone AJ
• A Multicenter, Open-Label Phase II Clinical Trial of Combined MEK plus EGFR Inhibition for Chemotherapy-Refractory Advanced Pancreatic Adenocarcinoma.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Ko AH, Bekaii-Saab T, Van Ziffle J, Mirzoeva OM, Joseph NM, Talasaz A, Kuhn P, Tempero MA, Collisson EA, Kelley RK, Venook AP, Dito E, Ong A, Ziyeh S, Courtin R, Linetskaya R, Tahiri S, Korn WM
• Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Lamagna C, Scapini P, van Ziffle JA, DeFranco AL, Lowell CA
• Deletion of Syk in neutrophils prevents immune complex arthritis.
  Journal of immunology (Baltimore, Md. : 1950) 2011 Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM, Lowell CA
• Homozygous deletion of six olfactory receptor genes in a subset of individuals with Beta-thalassemia.
  PloS one 2011 Van Ziffle J, Yang W, Chehab FF
• Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury.
  The Journal of clinical investigation 2009 Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA
• Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection.
  Blood 2009 Van Ziffle JA, Lowell CA
• Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase.
  Journal of leukocyte biology 2008 Paul R, Obermaier B, Van Ziffle J, Angele B, Pfister HW, Lowell CA, Koedel U
• Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy.
  Immunity 2006 Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, Shapiro SD, Lowell C, Mayadas TN
• Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo.
  Blood 2006 Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K
• Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury.
  The Journal of clinical investigation 2006 Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA
• The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Mócsai A, Humphrey MB, Van Ziffle JA, Hu Y, Burghardt A, Spusta SC, Majumdar S, Lanier LL, Lowell CA, Nakamura MC
• Telomere length in subpopulations of human hematopoietic cells.
  Stem cells (Dayton, Ohio) 2003 Van Ziffle JA, Baerlocher GM, Lansdorp PM
• Structure and evolution of 4-coumarate:coenzyme A ligase (4CL) gene families.
  Biological chemistry 2001 Cukovic D, Ehlting J, VanZiffle JA, Douglas CJ