Jes Alexander, PhD, MD
Assistant Professor
Radiation Oncology
School of Medicine
My research interests lie in the area of medical informatics and focus on electronic health records. In particular, I use cancer and radiation therapy as a lens to examine aspects of electronic health records.
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In recent work, I have developed a technique to identify side effects of procedures in unstructured electronic health record data, described a vulnerability in the de-identification of electronic health records, and examined the benefits of and disparities in the use of MyChart messages in radiation oncology patients. Future work will involve the application of the abovementioned technique to understand side effects in a national cohort of prostate cancer patients and a deeper investigation into the benefits of MyChart messaging.
Interests
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- Machine Learning
- Informatics
- Side Effects
- Cancer
- Radiation Therapy
- Electronic Health Records
Publications (12)
Top publication keywords:
Evolution, MolecularChromosomes, Human, Pair 7Single-Cell AnalysisConsensus SequenceStem CellsAmino Acid MotifsBrain NeoplasmsGliomaGenomeCRISPR-Cas SystemsNeoplastic Stem CellsMitosisCtenophoraXenopus ProteinsGene Editing
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Nonspecific deidentification of date-like text in deidentified clinical notes enables reidentification of dates
Journal of the Medical Informatics Association 2022 Jes Alexander, Alexis Beatty -
Relative Incidence of Emergency Department Visits After Treatment for Prostate Cancer With Radiation Therapy or Radical Prostatectomy
Practical Radiation Oncology 2022 Jes Alexander, Alexis Beatty, Osama Mohamad, I-Chow Joe Hsu -
Multimodal single-cell analysis reveals distinct radioresistant stem-like and progenitor cell populations in murine glioma.
Glia 2020 Alexander J, LaPlant QC, Pattwell SS, Szulzewsky F, Cimino PJ, Caruso FP, Pugliese P, Chen Z, Chardon F, Hill AJ, Spurrell C, Ahrendsen D, Pietras A, Starita LM, Hambardzumyan D, Iavarone A, Shendure … -
Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement.
BMC biology 2019 Alexander J, Findlay GM, Kircher M, Shendure J -
Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma.
Genes & development 2018 Cimino PJ, Kim Y, Wu HJ, Alexander J, Wirsching HG, Szulzewsky F, Pitter K, Ozawa T, Wang J, Vazquez J, Arora S, Rabadan R, Levine R, Michor F, Holland EC
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Pre-plan parameters predict post-implant D90 ≥ 140 Gy for (125)I permanent prostate implants.
Journal of contemporary brachytherapy 2014 Alexander J, Weinberg V, Gottschalk AR, Hsu IC, Shinohara K, Roach M -
Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling.
Science signaling 2011 Alexander J, Lim D, Joughin BA, Hegemann B, Hutchins JR, Ehrenberger T, Ivins F, Sessa F, Hudecz O, Nigg EA, Fry AM, Musacchio A, Stukenberg PT, Mechtler K, Peters JM, Smerdon SJ, Yaffe MB -
Linear motif atlas for phosphorylation-dependent signaling.
Science signaling 2008 Miller ML, Jensen LJ, Diella F, Jørgensen C, Tinti M, Li L, Hsiung M, Parker SA, Bordeaux J, Sicheritz-Ponten T, Olhovsky M, Pasculescu A, Alexander J, Knapp S, Blom N, Bork P, Li S, Cesareni G, … -
The NDR/LATS family kinase Cbk1 directly controls transcriptional asymmetry.
PLoS biology 2008 Mazanka E, Alexander J, Yeh BJ, Charoenpong P, Lowery DM, Yaffe M, Weiss EL -
Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate.
The EMBO journal 2007 Lowery DM, Clauser KR, Hjerrild M, Lim D, Alexander J, Kishi K, Ong SE, Gammeltoft S, Carr SA, Yaffe MB -
Diagnostic markers that distinguish colon and ovarian adenocarcinomas: identification by genomic, proteomic, and tissue array profiling.
Cancer research 2003 Nishizuka S, Chen ST, Gwadry FG, Alexander J, Major SM, Scherf U, Reinhold WC, Waltham M, Charboneau L, Young L, Bussey KJ, Kim S, Lababidi S, Lee JK, Pittaluga S, Scudiero DA, Sausville EA, Munson PJ… -
Apoptotic susceptibility of cancer cells selected for camptothecin resistance: gene expression profiling, functional analysis, and molecular interaction mapping.
Cancer research 2003 Reinhold WC, Kouros-Mehr H, Kohn KW, Maunakea AK, Lababidi S, Roschke A, Stover K, Alexander J, Pantazis P, Miller L, Liu E, Kirsch IR, Urasaki Y, Pommier Y, Weinstein JN