Jeremy Shea, PhD
Associate Specialist
Anatomy
School of Medicine

Grants and Projects

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• Investigating the role of the microenvironment in microglial aging, NIH, 2017-2020

Publications (11)

Top publication keywords:
Mucopolysaccharidosis VIICognitive AgingGenomeRNA, Transfer, GlySperm MaturationEpigenesis, GeneticGenetic VariationDNA, RibosomalBrainProto-Oncogene ProteinsFetal TherapiesSpermatozoaAgingGenes, X-LinkedDioxygenases

• Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function.
  Cell reports 2023 Pratt KJB, Shea JM, Remesal-Gomez L, Bieri G, Smith LK, Couthouis J, Chen CP, Roy IJ, Gontier G, Villeda SA
• Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function.
  Cell reports 2022 Pratt KJB, Shea JM, Remesal-Gomez L, Bieri G, Smith LK, Couthouis J, Chen CP, Roy IJ, Gontier G, Villeda SA
• Dampening the Power of the Brain-When Aging Meets Cognition.
  The journals of gerontology. Series A, Biological sciences and medical sciences 2020 Shea JM, Villeda SA
• Tolerance induction and microglial engraftment after fetal therapy without conditioning in mice with Mucopolysaccharidosis type VII.
  Science translational medicine 2020 Nguyen QH, Witt RG, Wang B, Eikani C, Shea J, Smith LK, Boyle G, Cadaoas J, Sper R, MacKenzie JD, Villeda S, MacKenzie TC
• Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain.
  Cell reports 2018 Gontier G, Iyer M, Shea JM, Bieri G, Wheatley EG, Ramalho-Santos M, Villeda SA

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• Regulation of X-linked gene expression during early mouse development by Rlim.
  eLife 2016 Wang F, Shin J, Shea JM, Yu J, Boškovic A, Byron M, Zhu X, Shalek AK, Regev A, Lawrence JB, Torres EM, Zhu LJ, Rando OJ, Bach I
• Microglia communication: Parallels between aging and Alzheimer's disease.
  Clinical & experimental neuroimmunology 2016 Udeochu JC, Shea JM, Villeda SA
• Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals.
  Science (New York, N.Y.) 2015 Sharma U, Conine CC, Shea JM, Boskovic A, Derr AG, Bing XY, Belleannee C, Kucukural A, Serra RW, Sun F, Song L, Carone BR, Ricci EP, Li XZ, Fauquier L, Moore MJ, Sullivan R, Mello CC, Garber M, Rando …
• Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome.
  Developmental cell 2015 Shea JM, Serra RW, Carone BR, Shulha HP, Kucukural A, Ziller MJ, Vallaster MP, Gu H, Tapper AR, Gardner PD, Meissner A, Garber M, Rando OJ
• Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals.
  Cell 2010 Carone BR, Fauquier L, Habib N, Shea JM, Hart CE, Li R, Bock C, Li C, Gu H, Zamore PD, Meissner A, Weng Z, Hofmann HA, Friedman N, Rando OJ
• Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment.
  Cell 2007 Walkley CR, Shea JM, Sims NA, Purton LE, Orkin SH