Jeoung-Sook Shin, PhD
Professor Emeritus
Microbiology and Immunology
School of Medicine

Websites

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• Shin Lab (shinlab.ucsf.edu)

Grants and Projects

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• Mechanism and function of membrane trafficking in dendritic cells, NIH/NIGMS, 2019-2024
• Assessing the candidacy of MARCH1 as a therapeutic target for treatment of asthma, DOD/CDMRP, 2018-2019
• Role of MARCH1 E3 ubiquitin ligase in thymic dendritic cell function, NIH, 2013-2019

Publications (31)

Top publication keywords:
Dendritic CellsThymocytesAntigen PresentationReceptors, IgEImmunoglobulin EUbiquitin-Protein LigasesCaveolaeEndocytosisMembrane MicrodomainsTh2 CellsVascular Endothelial Growth Factor Receptor-1UbiquitinationTetraspaninsT-Lymphocytes, RegulatoryHistocompatibility Antigens Class II

• CD40 Mediates Maturation of Thymic Dendritic Cells Driven by Self-Reactive CD4+ Thymocytes and Supports Development of Natural Regulatory T Cells.
  Journal of immunology (Baltimore, Md. : 1950) 2018 Oh J, Wu N, Barczak AJ, Barbeau R, Erle DJ, Shin JS
• Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses.
  The Journal of experimental medicine 2016 Bannard O, McGowan SJ, Ersching J, Ishido S, Victora GD, Shin JS, Cyster JG
• Molecular mechanism and cellular function of MHCII ubiquitination.
  Immunological reviews 2015 Oh J, Shin JS
• The role of FcεRI expressed in dendritic cells and monocytes.
  Cellular and molecular life sciences : CMLS 2015 Shin JS, Greer AM
• Serum IgE clearance is facilitated by human FcεRI internalization.
  The Journal of clinical investigation 2014 Greer AM, Wu N, Putnam AL, Woodruff PG, Wolters P, Kinet JP, Shin JS
• MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells.
  The Journal of experimental medicine 2013 Oh J, Wu N, Baravalle G, Cohn B, Ma J, Lo B, Mellman I, Ishido S, Anderson M, Shin JS
• Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination.
  Nature 2006 Shin JS, Ebersold M, Pypaert M, Delamarre L, Hartley A, Mellman I

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• IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis.
  Science immunology 2023 Fassett MS, Braz JM, Castellanos CA, Salvatierra JJ, Sadeghi M, Yu X, Schroeder AW, Caston J, Munoz-Sandoval P, Roy S, Lazarevsky S, Mar DJ, Zhou CJ, Shin JS, Basbaum AI, Ansel KM
• MARCH1 Controls an Exhaustion-like Program of Effector CD4⁺ T Cells Promoting Allergic Airway Inflammation.
  ImmunoHorizons 2022 Castellanos CA, Hiam-Galvez KJ, Ishido S, Satpathy AT, Shin JS
• Lymph node-resident dendritic cells drive TH2 cell development involving MARCH1.
  Science immunology 2021 Castellanos CA, Ren X, Gonzalez SL, Li HK, Schroeder AW, Liang HE, Laidlaw BJ, Hu D, Mak ACY, Eng C, Rodríguez-Santana JR, LeNoir M, Yan Q, Celedón JC, Burchard EG, Zamvil SS, Ishido S, Locksley RM, …
• A Defect in Thymic Tolerance Causes T Cell-Mediated Autoimmunity in a Murine Model of COPA Syndrome.
  Journal of immunology (Baltimore, Md. : 1950) 2020 Deng Z, Law CS, Ho FO, Wang KM, Jones KD, Shin JS, Shum AK
• Unexpected role of dendritic cells in pulmonary fibrosis.
  Thorax 2019 Shin JS
• March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity.
  Nature communications 2018 Borges TJ, Murakami N, Machado FD, Murshid A, Lang BJ, Lopes RL, Bellan LM, Uehara M, Antunes KH, Pérez-Saéz MJ, Birrane G, Vianna P, Gonçalves JIB, Zanin RF, Azzi J, Abdi R, Ishido S, Shin JS, Souza …
• MARCH1 protects the lipid raft and tetraspanin web from MHCII proteotoxicity in dendritic cells.
  The Journal of cell biology 2018 Oh J, Perry JSA, Pua H, Irgens-Möller N, Ishido S, Hsieh CS, Shin JS
• The Role of Dendritic Cells in Central Tolerance.
  Immune network 2015 Oh J, Shin JS
• Accumulation of BDCA1⁺ dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma.
  PloS one 2014 Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin JS
• Accelerated dissociation of IgE-FcεRI complexes by disruptive inhibitors actively desensitizes allergic effector cells.
  The Journal of allergy and clinical immunology 2014 Eggel A, Baravalle G, Hobi G, Kim B, Buschor P, Forrer P, Shin JS, Vogel M, Stadler BM, Dahinden CA, Jardetzky TS
• Antigen-conjugated human IgE induces antigen-specific T cell tolerance in a humanized mouse model.
  Journal of immunology (Baltimore, Md. : 1950) 2014 Baravalle G, Greer AM, LaFlam TN, Shin JS
• MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Ma JK, Platt MY, Eastham-Anderson J, Shin JS, Mellman I
• Ubiquitination of CD86 is a key mechanism in regulating antigen presentation by dendritic cells.
  Journal of immunology (Baltimore, Md. : 1950) 2011 Baravalle G, Park H, McSweeney M, Ohmura-Hoshino M, Matsuki Y, Ishido S, Shin JS
• Spinophilin participates in information transfer at immunological synapses.
  The Journal of cell biology 2008 Bloom O, Unternaehrer JJ, Jiang A, Shin JS, Delamarre L, Allen P, Mellman I
• Harboring of particulate allergens within secretory compartments by mast cells following IgE/FcepsilonRI-lipid raft-mediated phagocytosis.
  Journal of immunology (Baltimore, Md. : 1950) 2006 Shin JS, Shelburne CP, Jin C, LeFurgey EA, Abraham SN
• Bacterial penetration of bladder epithelium through lipid rafts.
  The Journal of biological chemistry 2004 Duncan MJ, Li G, Shin JS, Carson JL, Abraham SN
• Microbial entry through caveolae: variations on a theme.
  Cellular microbiology 2002 Duncan MJ, Shin JS, Abraham SN
• Cell biology. Caveolae--not just craters in the cellular landscape.
  Science (New York, N.Y.) 2001 Shin JS, Abraham SN
• Caveolae as portals of entry for microbes.
  Microbes and infection 2001 Shin JS, Abraham SN
• Glycosylphosphatidylinositol-anchored receptor-mediated bacterial endocytosis.
  FEMS microbiology letters 2001 Shin JS, Abraham SN
• Type 1 fimbriated Escherichia coli-mast cell interactions in cystitis.
  The Journal of infectious diseases 2001 Abraham S, Shin J, Malaviya R
• Co-option of endocytic functions of cellular caveolae by pathogens.
  Immunology 2001 Shin JS, Abraham SN
• Involvement of cellular caveolae in bacterial entry into mast cells.
  Science (New York, N.Y.) 2000 Shin JS, Gao Z, Abraham SN
• Bacteria-host cell interaction mediated by cellular cholesterol/glycolipid-enriched microdomains.
  Bioscience reports 1999 Shin JS, Gao Z, Abraham SN