Jennifer Yokoyama, PhD
Associate Professor
Neurology
School of Medicine

Utilizing community-based canine DNA samples, Dr. Yokoyama performed genome-wide surveys for genetic loci underlying the canine anxiety disorder noise phobia, as well as for loci underlying adult-onset deafness in border collies.

Dr. Yokoyama is currently an Assistant Professor at the Memory and Aging Center, where she is beginning a research program in neurogenetics of aging. Specifically, she is interested in the effect genotype can have on brain physiology, behavior and cognition in healthy older adults, and how this is related to increased vulnerability to (or protection from) neurodegenerative processes during aging. She is also particularly interested in understanding these effects in diverse ethnic populations. Dr. Yokoyama's long-term goal is to understand how variation across the entire genome confers risk for particular types of neurodegeneration for purposes of early treatment and therapeutic intervention.

• Assessing the lack of diversity in genetics research across neurodegenerative diseases: a systematic review of the GWAS Catalog and literature.
  medRxiv : the preprint server for health sciences 2024 Jonson C, Levine KS, Lake J, Hertslet L, Jones L, Patel D, Kim J, Bandres-Ciga S, Terry N, Mata IF, Blauwendraat C, Singleton AB, Nalls MA, Yokoyama JS, Leonard HL
• Eosinophilic myocarditis: systematic review.
  Heart (British Cardiac Society) 2023 Techasatian W, Gozun M, Vo K, Yokoyama J, Nagamine T, Shah P, Vu K, Zhang J, Nishimura Y
• FTLD targets brain regions expressing recently evolved genes.
  medRxiv : the preprint server for health sciences 2023 Pasquini L, Pereira FL, Seddighi S, Zeng Y, Wei Y, Illán-Gala I, Vatsavayai SC, Friedberg A, Lee AJ, Brown JA, Spina S, Grinberg LT, Sirkis DW, Bonham LW, Yokoyama JS, Boxer AL, Kramer JH, Rosen HJ, …
• An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome.
  Research square 2023 Snyder A, Ryan VH, Hawrot J, Lawton S, Ramos DM, Qi YA, Johnson K, Reed X, Johnson NL, Kollasch AW, Duffy M, VandeVrede L, Cochran JN, Miller BL, Toro C, Bielekova B, Yokoyama JS, Marks DS, Kwan JY, …
• Early-onset Alzheimer's disease explained by polygenic risk of late-onset disease?
  Alzheimer's & dementia (Amsterdam, Netherlands) 2023 Mantyh WG, Cochran JN, Taylor JW, Broce IJ, Geier EG, Bonham LW, Anderson AG, Sirkis DW, Joie R, Iaccarino L, Chaudhary K, Edwards L, Strom A, Grant H, Allen IE, Miller ZA, Gorno-Tempini ML, Kramer JH…
• Role for cell death pathway in Alzheimer's disease.
  Science (New York, N.Y.) 2023 Sirkis DW, Yokoyama JS
• Network Connectivity Alterations across the MAPT Mutation Clinical Spectrum.
  Annals of neurology 2023 Zhang L, Flagan TM, Häkkinen S, Chu SA, Brown JA, Lee AJ, Pasquini L, Mandelli ML, Gorno-Tempini ML, Sturm VE, Yokoyama JS, Appleby BS, Cobigo Y, Dickerson BC, Domoto-Reilly K, Geschwind DH, Ghoshal N…
• C9orf72 gene networks in the human brain correlate with cortical thickness in C9-FTD and implicate vulnerable cell types.
  bioRxiv : the preprint server for biology 2023 Broce IJ, Sirkis DW, Nillo RM, Bonham LW, Lee SE, Miller B, Castruita P, Sturm VE, Sugrue LS, Desikan RS, Yokoyama JS
• Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy.
  Genome medicine 2023 Sirkis DW, Warly Solsberg C, Johnson TP, Bonham LW, Sturm VE, Lee SE, Rankin KP, Rosen HJ, Boxer AL, Seeley WW, Miller BL, Geier EG, Yokoyama JS
• Genetic overlap between cortical brain morphometry and frontotemporal dementia risk.
  Cerebral cortex (New York, N.Y. : 1991) 2023 Diaz-Torres S, Ogonowski N, García-Marín LM, Bonham LW, Duran-Aniotz C, Yokoyama JS, Rentería ME
• Gaps in clinical research in frontotemporal dementia: A call for diversity and disparities-focused research.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Franzen S, Nuytemans K, Bourdage R, Caramelli P, Ellajosyula R, Finger E, Illán-Gala I, Loi SM, Morhardt D, Pijnenburg Y, Rascovsky K, Williams MM, Yokoyama JS, Alladi S, Ayhan Y, Broce I, Castro-…
• Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease.
  Molecular psychiatry 2023 Lake J, Warly Solsberg C, Kim JJ, Acosta-Uribe J, Makarious MB, Li Z, Levine K, Heutink P, Alvarado CX, Vitale D, Kang S, Gim J, Lee KH, Pina-Escudero SD, Ferrucci L, Singleton AB, Blauwendraat C, …
• Prevalence, Timing, and Network Localization of Emergent Visual Creativity in Frontotemporal Dementia.
  JAMA neurology 2023 Friedberg A, Pasquini L, Diggs R, Glaubitz EA, Lopez L, Illán-Gala I, Iaccarino L, La Joie R, Mundada N, Knudtson M, Neylan K, Brown J, Allen IE, Rankin KP, Bonham LW, Yokoyama JS, Ramos EM, Geschwind…
• Treatment resistant depression in elderly.
  Progress in brain research 2023 Wang SC, Yokoyama JS, Tzeng NS, Tsai CF, Liu MN
• Medium Roasting and Brewing Methods Differentially Modulate Global Metabolites, Lipids, Biogenic Amines, Minerals, and Antioxidant Capacity of Hawai'i-Grown Coffee (Coffea arabica).
  Metabolites 2023 Nerurkar PV, Yokoyama J, Ichimura K, Kutscher S, Wong J, Bittenbender HC, Deng Y
• Discovery of genomic loci associated with sleep apnea risk through multi-trait GWAS analysis with snoring.
  Sleep 2023 Campos AI, Ingold N, Huang Y, Mitchell BL, Kho PF, Han X, García-Marín LM, Ong JS, 23andMe Research Team, Law MH, Yokoyama JS, Martin NG, Dong X, Cuellar-Partida G, MacGregor S, Aslibekyan S, Rentería…
• The impacts of social determinants of health and cardiometabolic factors on cognitive and functional aging in Colombian underserved populations.
  GeroScience 2023 Santamaria-Garcia H, Moguilner S, Rodriguez-Villagra OA, Botero-Rodriguez F, Pina-Escudero SD, O'Donovan G, Albala C, Matallana D, Schulte M, Slachevsky A, Yokoyama JS, Possin K, Ndhlovu LC, Al-Rousan…
• Frontotemporal dementia presentation in patients with heterozygous p.H157Y variant of TREM2.
  Journal of medical genetics 2023 Ogonowski N, Santamaria-Garcia H, Baez S, Lopez A, Laserna A, Garcia-Cifuentes E, Ayala-Ramirez P, Zarante I, Suarez-Obando F, Reyes P, Kauffman M, Cochran N, Schulte M, Sirkis DW, Spina S, Yokoyama …
• Sex-specific effects of SNAP-25 genotype on verbal memory and Alzheimer's disease biomarkers in clinically normal older adults.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Saloner R, Paolillo EW, Wojta KJ, Fonseca C, Gontrum EQ, Lario-Lago A, Rabinovici GD, Yokoyama JS, Rexach JE, Kramer JH, Casaletto KB
• Increasing empathic concern relates to salience network hyperconnectivity in cognitively healthy older adults with elevated amyloid-β burden.
  NeuroImage. Clinical 2022 Chow TE, Veziris CR, La Joie R, Lee AJ, Brown JA, Yokoyama JS, Rankin KP, Kramer JH, Miller BL, Rabinovici GD, Seeley WW, Sturm VE
• Radiogenomics of C9orf72 Expansion Carriers Reveals Global Transposable Element Derepression and Enables Prediction of Thalamic Atrophy and Clinical Impairment.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Bonham LW, Geier EG, Sirkis DW, Leong JK, Ramos EM, Wang Q, Karydas A, Lee SE, Sturm VE, Sawyer RP, Friedberg A, Ichida JK, Gitler AD, Sugrue L, Cordingley M, Bee W, Weber E, Kramer JH, Rankin KP, …
• Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease.
  Nature genetics 2022 Holstege H, Hulsman M, Charbonnier C, Grenier-Boley B, Quenez O, Grozeva D, van Rooij JGJ, Sims R, Ahmad S, Amin N, Norsworthy PJ, Dols-Icardo O, Hummerich H, Kawalia A, Amouyel P, Beecham GW, Berr C,…
• Classification of Alzheimer's disease and frontotemporal dementia using routine clinical and cognitive measures across multicentric underrepresented samples: A cross sectional observational study.
  Lancet regional health. Americas 2022 Maito MA, Santamaría-García H, Moguilner S, Possin KL, Godoy ME, Avila-Funes JA, Behrens MI, Brusco IL, Bruno MA, Cardona JF, Custodio N, García AM, Javandel S, Lopera F, Matallana DL, Miller B, de …
• Genetic, Social, and Lifestyle Drivers of Healthy Aging and Longevity.
  Current genetic medicine reports 2022 Castruita PA, Piña-Escudero SD, Rentería ME, Yokoyama JS
• Eosinophilic Myocarditis Presenting as Cardiac Tamponade: A Diagnostic Challenge.
  European journal of case reports in internal medicine 2022 Vo K, Nishimura Y, Yokoyama J, Wasko A, Miyake T, Vu K, Zhang J, Pino Moreno J, Banerjee D, Kim L, Chong C
• Biomarkers for dementia in Latin American countries: Gaps and opportunities.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2022 Parra MA, Orellana P, Leon T, Victoria CG, Henriquez F, Gomez R, Avalos C, Damian A, Slachevsky A, Ibañez A, Zetterberg H, Tijms BM, Yokoyama JS, Piña-Escudero SD, Cochran JN, Matallana DL, Acosta D, …
• Case Report: Novel CSF1R Variant in a Patient With Behavioral Variant Frontotemporal Dementia Syndrome With Prodromal Repetitive Scratching Behavior.
  Frontiers in neurology 2022 Friedberg A, Ramos EM, Yang Z, Bonham LW, Yokoyama JS, Ljubenkov PA, Younes K, Geschwind DH, Miller BL
• Dissecting the clinical heterogeneity of early-onset Alzheimer's disease.
  Molecular psychiatry 2022 Sirkis DW, Bonham LW, Johnson TP, La Joie R, Yokoyama JS
• Candidate Epigenetic Biomarker of Cognitive Trajectory: The Chicken or the Egg?
  Biological psychiatry 2022 Corley MJ, Yokoyama JS
• Race, Genetic Admixture, and Cognitive Performance in the Cuban Population.
  The journals of gerontology. Series A, Biological sciences and medical sciences 2022 Llibre-Guerra JJ, Li Y, Allen IE, Llibre-Guerra JC, Rodríguez Salgado AM, Peñalver AI, Almirall Sanchez A, Yokoyama JS, Grinberg L, Valcour V, Miller BL, Llibre-Rodríguez JJ
• Differences in peripheral immune system gene expression in frontotemporal degeneration.
  Medicine 2022 Sawyer RP, Hill EJ, Yokoyama J, Medvedovic M, Ren Y, Zhang X, Choubey D, Shatz RS, Miller B, Woo D
• TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy.
  Science advances 2021 Alquezar C, Schoch KM, Geier EG, Ramos EM, Scrivo A, Li KH, Argouarch AR, Mlynarski EE, Dombroski B, DeTure M, Dickson DW, Yokoyama JS, Cuervo AM, Burlingame AL, Schellenberg GD, Miller TM, Miller BL,…
• Personal Utility and Early Intervention in Alzheimer's Disease.
  AJOB neuroscience 2021 Tyler AM, Yokoyama JS, Arias JJ
• Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease.
  JAMA neurology 2021 Davis EJ, Solsberg CW, White CC, Miñones-Moyano E, Sirota M, Chibnik L, Bennett DA, De Jager PL, Yokoyama JS, Dubal DB
• Systematic Review: Genetic, Neuroimaging, and Fluids Biomarkers for Frontotemporal Dementia Across Latin America Countries.
  Frontiers in neurology 2021 Duran-Aniotz C, Orellana P, Leon Rodriguez T, Henriquez F, Cabello V, Aguirre-Pinto MF, Escobedo T, Takada LT, Pina-Escudero SD, Lopez O, Yokoyama JS, Ibanez A, Parra MA, Slachevsky A
• Constraints on Cosmic Strings Using Data from the Third Advanced LIGO-Virgo Observing Run.
  Physical review letters 2021 Abbott R, Abbott TD, Abraham S, Acernese F, Ackley K, Adams A, Adams C, Adhikari RX, Adya VB, Affeldt C, Agarwal D, Agathos M, Agatsuma K, Aggarwal N, Aguiar OD, Aiello L, Ain A, Ajith P, Akutsu T, …
• The Role of Microglia in Inherited White-Matter Disorders and Connections to Frontotemporal Dementia.
  The application of clinical genetics 2021 Sirkis DW, Bonham LW, Yokoyama JS
• Genetic pleiotropy and the shared pathological features of corticobasal degeneration and progressive supranuclear palsy: a case report and a review of the literature.
  Neurocase 2021 Rini J, Asken B, Geier E, Rankin K, Kramer J, Boxer A, Miller B, Yokoyama J, Spina S
• The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science.
  Frontiers in neurology 2021 Ibanez A, Yokoyama JS, Possin KL, Matallana D, Lopera F, Nitrini R, Takada LT, Custodio N, Sosa Ortiz AL, Avila-Funes JA, Behrens MI, Slachevsky A, Myers RM, Cochran JN, Brusco LI, Bruno MA, Brucki …
• Moving Toward Patient-Tailored Treatment in ALS and FTD: The Potential of Genomic Assessment as a Tool for Biological Discovery and Trial Recruitment.
  Frontiers in neuroscience 2021 Broce IJ, Castruita PA, Yokoyama JS
• SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan.
  Nature communications 2021 Johnson AE, Orr BO, Fetter RD, Moughamian AJ, Primeaux LA, Geier EG, Yokoyama JS, Miller BL, Davis GW
• p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR).
  Cell 2021 Maor-Nof M, Shipony Z, Lopez-Gonzalez R, Nakayama L, Zhang YJ, Couthouis J, Blum JA, Castruita PA, Linares GR, Ruan K, Ramaswami G, Simon DJ, Nof A, Santana M, Han K, Sinnott-Armstrong N, Bassik MC, …
• Brain volumetric deficits in MAPT mutation carriers: a multisite study.
  Annals of clinical and translational neurology 2020 Chu SA, Flagan TM, Staffaroni AM, Jiskoot LC, Deng J, Spina S, Zhang L, Sturm VE, Yokoyama JS, Seeley WW, Papma JM, Geschwind DH, Rosen HJ, Boeve BF, Boxer AL, Heuer HW, Forsberg LK, Brushaber DE, …
• The power of knowledge about dementia in Latin America across health professionals working on aging.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2020 Ibanez A, Flichtentrei D, Hesse E, Dottori M, Tomio A, Slachevsky A, Serrano CM, Gonzalez-Billaut C, Custodio N, Miranda C, Bustin J, Cetckovitch M, Torrente F, Olavarria L, Leon T, Beber BC, Bruki S,…
• Prospects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA.
  Living reviews in relativity 2020 Abbott BP, Abbott R, Abbott TD, Abraham S, Acernese F, Ackley K, Adams C, Adya VB, Affeldt C, Agathos M, Agatsuma K, Aggarwal N, Aguiar OD, Aiello L, Ain A, Ajith P, Akutsu T, Allen G, Allocca A, Aloy…
• C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts.
  Neurology 2020 Costa B, Manzoni C, Bernal-Quiros M, Kia DA, Aguilar M, Alvarez I, Alvarez V, Andreassen O, Anfossi M, Bagnoli S, Benussi L, Bernardi L, Binetti G, Blackburn D, Boada M, Borroni B, Bowns L, Bråthen G,…
• Response to Holstege et al.
  American journal of human genetics 2020 Cochran JN, Myers RM, Yokoyama JS
• A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease.
  Science translational medicine 2020 Davis EJ, Broestl L, Abdulai-Saiku S, Worden K, Bonham LW, Miñones-Moyano E, Moreno AJ, Wang D, Chang K, Williams G, Garay BI, Lobach I, Devidze N, Kim D, Anderson-Bergman C, Yu GQ, White CC, Harris …
• No association between the COMT Val158Met polymorphism and cognitive training response in healthy Shanghai community-dwelling elderly individuals.
  Annals of palliative medicine 2020 Feng W, Yu Z, Yu S, Wu W, Yokoyama JS, Li C
• Lack of Association Between the CCR5-delta32 Polymorphism and Neurodegenerative Disorders.
  Alzheimer disease and associated disorders 2020 Wojta KJ, Ayer AH, Ramos EM, Nguyen PD, Karydas AM, Yokoyama JS, Kramer J, Lee SE, Boxer A, Miller BL, Coppola G
• Longevity Gene KLOTHO and Alzheimer Disease-A Better Fate for Individuals Who Carry APOE ε4.
  JAMA neurology 2020 Dubal DB, Yokoyama JS
• Association Between Chronic Kidney Disease-Mineral Bone Disease (CKD-MBD) and Cognition in Children: Chronic Kidney Disease in Children (CKiD) Study.
  Kidney medicine 2020 Yokoyama JS, Matsuda-Abedini M, Denburg MR, Kumar J, Warady BA, Furth SL, Hooper SR, Portale AA, Perwad F
• Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases.
  American journal of human genetics 2020 Cochran JN, Geier EG, Bonham LW, Newberry JS, Amaral MD, Thompson ML, Lasseigne BN, Karydas AM, Roberson ED, Cooper GM, Rabinovici GD, Miller BL, Myers RM, Yokoyama JS, Alzheimer’s Disease …
• Genome sequencing for early-onset or atypical dementia: high diagnostic yield and frequent observation of multiple contributory alleles.
  Cold Spring Harbor molecular case studies 2019 Cochran JN, McKinley EC, Cochran M, Amaral MD, Moyers BA, Lasseigne BN, Gray DE, Lawlor JMJ, Prokop JW, Geier EG, Holt JM, Thompson ML, Newberry JS, Yokoyama JS, Worthey EA, Geldmacher DS, Love MN, …
• The Radiogenomics of Late-onset Alzheimer Disease.
  Topics in magnetic resonance imaging : TMRI 2019 Bonham LW, Sirkis DW, Hess CP, Sugrue LP, Yokoyama JS
• Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders.
  Alzheimer disease and associated disorders 2019 Ayer AH, Wojta K, Ramos EM, Dokuru D, Chen JA, Karydas AM, Papatriantafyllou JD, Agiomyrgiannakis D, Kamtsadeli V, Tsinia N, Sali D, Gylys KH, Agosta F, Filippi M, Small GW, Bennett DA, Gearing M, …
• Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia.
  Scientific reports 2019 Bonham LW, Steele NZR, Karch CM, Broce I, Geier EG, Wen NL, Momeni P, Hardy J, Miller ZA, Gorno-Tempini ML, Hess CP, Lewis P, Miller BL, Seeley WW, Manzoni C, Desikan RS, Baranzini SE, Ferrari R, …
• Alzheimer Disease-associated Cortical Atrophy Does not Differ Between Chinese and Whites.
  Alzheimer disease and associated disorders 2019 Fan J, Tse M, Carr JS, Miller BL, Kramer JH, Rosen HJ, Bonham LW, Yokoyama JS
• The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease.
  Frontiers in immunology 2019 Bonham LW, Sirkis DW, Yokoyama JS
• Immunological signatures in frontotemporal lobar degeneration.
  Current opinion in neurology 2019 Sirkis DW, Bonham LW, Karch CM, Yokoyama JS
• Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr).
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2019 Ramirez Aguilar L, Acosta-Uribe J, Giraldo MM, Moreno S, Baena A, Alzate D, Cuastumal R, Aguillón D, Madrigal L, Saldarriaga A, Navarro A, Garcia GP, Aguirre-Acevedo DC, Geier EG, Cochran JN, Quiroz …
• Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.
  Acta neuropathologica 2019 Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, Matchett …
• Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration.
  Brain : a journal of neurology 2019 Tan CH, Bonham LW, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Yokoyama JS, Rabinovici GD, Miller BL, Yaffe K, Schellenberg GD, Kauppi K, Holland D, McEvoy LK, Kukull WA, Tosun D, Weiner MW, …
• Recent advances in the genetics of frontotemporal dementia.
  Current genetic medicine reports 2019 Sirkis DW, Geier EG, Bonham LW, Karch CM, Yokoyama JS
• Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease.
  Acta neuropathologica 2018 Broce IJ, Tan CH, Fan CC, Jansen I, Savage JE, Witoelar A, Wen N, Hess CP, Dillon WP, Glastonbury CM, Glymour M, Yokoyama JS, Elahi FM, Rabinovici GD, Miller BL, Mormino EC, Sperling RA, Bennett DA, …
• Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia.
  Acta neuropathologica 2018 Geier EG, Bourdenx M, Storm NJ, Cochran JN, Sirkis DW, Hwang JH, Bonham LW, Ramos EM, Diaz A, Van Berlo V, Dokuru D, Nana AL, Karydas A, Balestra ME, Huang Y, Russo SP, Spina S, Grinberg LT, Seeley WW…
• C9orf72-FTD/ALS pathogenesis: evidence from human neuropathological studies.
  Acta neuropathologica 2018 Vatsavayai SC, Nana AL, Yokoyama JS, Seeley WW
• Frequency of frontotemporal dementia gene variants in C9ORF72, MAPT, and GRN in academic versus commercial laboratory cohorts.
  Advances in genomics and genetics 2018 Steele NZ, Bright AR, Lee SE, Fong JC, Bonham LW, Karydas A, Karbassi ID, Pribadi M, Meservey MA, Gallen MC, Ramos EM, Liaquat K, Hoffman CC, Krasner MR, Dodge W, L Miller B, Coppola G, Rankin KP, …
• Protein network analysis reveals selectively vulnerable regions and biological processes in FTD.
  Neurology. Genetics 2018 Bonham LW, Steele NZR, Karch CM, Manzoni C, Geier EG, Wen N, Ofori-Kuragu A, Momeni P, Hardy J, Miller ZA, Hess CP, Lewis P, Miller BL, Seeley WW, Baranzini SE, Desikan RS, Ferrari R, Yokoyama JS, …
• Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex.
  Scientific reports 2018 Li Y, Barkovich MJ, Karch CM, Nillo RM, Fan CC, Broce IJ, Tan CH, Cuneo D, Hess CP, Dillon WP, Glenn OA, Glastonbury CM, Olney N, Yokoyama JS, Bonham LW, Miller B, Kao A, Schmansky N, Fischl B, …
• Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases.
  Molecular neurodegeneration 2018 Chen JA, Chen Z, Won H, Huang AY, Lowe JK, Wojta K, Yokoyama JS, Bensimon G, Leigh PN, Payan C, Shatunov A, Jones AR, Lewis CM, Deloukas P, Amouyel P, Tzourio C, Dartigues JF, Ludolph A, Boxer AL, …
• Genetic Variation in the Androgen Receptor and Measures of Plasma Testosterone Levels Suggest Androgen Dysfunction in Alzheimer's Disease.
  Frontiers in neuroscience 2018 Carr JS, Bonham LW, Morgans AK, Ryan CJ, Yokoyama JS, Geier EG, Alzheimer’s Disease Neuroimaging Initiative
• Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer's Disease Pathology and Shows Differential Expression in Transgenic Mice.
  Frontiers in neuroscience 2018 Bonham LW, Geier EG, Steele NZR, Holland D, Miller BL, Dale AM, Desikan RS, Yokoyama JS, Alzheimer’s Disease Neuroimaging Initiative
• Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum.
  JAMA neurology 2018 Karch CM, Wen N, Fan CC, Yokoyama JS, Kouri N, Ross OA, Höglinger G, Müller U, Ferrari R, Hardy J, Schellenberg GD, Sleiman PM, Momeni P, Hess CP, Miller BL, Sharma M, Van Deerlin V, Smeland OB, …
• Prospects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA.
  Living reviews in relativity 2018 Abbott BP, Abbott R, Abbott TD, Abernathy MR, Acernese F, Ackley K, Adams C, Adams T, Addesso P, Adhikari RX, Adya VB, Affeldt C, Agathos M, Agatsuma K, Aggarwal N, Aguiar OD, Aiello L, Ain A, Ajith P…
• CXCR4 involvement in neurodegenerative diseases.
  Translational psychiatry 2018 Bonham LW, Karch CM, Fan CC, Tan C, Geier EG, Wang Y, Wen N, Broce IJ, Li Y, Barkovich MJ, Ferrari R, Hardy J, Momeni P, Höglinger G, Müller U, Hess CP, Sugrue LP, Dillon WP, Schellenberg GD, Miller …
• Correction: Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.
  PLoS medicine 2018 Broce I, Karch CM, Wen N, Fan CC, Wang Y, Tan CH, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J, International FTD-Genomics Consortium, Momeni P, Hess CP, Dillon WP, Miller ZA, Bonham LW, …
• Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes.
  American journal of Alzheimer's disease and other dementias 2018 Bonham LW, Evans DS, Liu Y, Cummings SR, Yaffe K, Yokoyama JS
• Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.
  PLoS medicine 2018 Broce I, Karch CM, Wen N, Fan CC, Wang Y, Tan CH, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J, International FTD-Genomics Consortium, Momeni P, Hess CP, Dillon WP, Miller ZA, Bonham LW, …
• Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition.
  Acta neuropathologica 2017 Tan CH, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Dillon WP, Bonham LW, Yokoyama JS, Karch CM, Brewer JB, Rabinovici GD, Miller BL, Schellenberg GD, Kauppi K, Feldman HA, Holland D, McEvoy LK,…
• Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging.
  Brain imaging and behavior 2017 Yokoyama JS, Marx G, Brown JA, Bonham LW, Wang D, Coppola G, Seeley WW, Rosen HJ, Miller BL, Kramer JH, Dubal DB
• Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study.
  PLoS medicine 2017 Steele NZ, Carr JS, Bonham LW, Geier EG, Damotte V, Miller ZA, Desikan RS, Boehme KL, Mukherjee S, Crane PK, Kauwe JS, Kramer JH, Miller BL, Coppola G, Hollenbach JA, Huang Y, Yokoyama JS
• Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.
  PLoS medicine 2017 Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen …
• Youthful Processing Speed in Older Adults: Genetic, Biological, and Behavioral Predictors of Cognitive Processing Speed Trajectories in Aging.
  Frontiers in aging neuroscience 2017 Bott NT, Bettcher BM, Yokoyama JS, Frazier DT, Wynn M, Karydas A, Yaffe K, Kramer JH
• Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia.
  Acta neuropathologica 2017 Yokoyama JS, Karch CM, Fan CC, Bonham LW, Kouri N, Ross OA, Rademakers R, Kim J, Wang Y, Höglinger GU, Müller U, Ferrari R, Hardy J, International FTD-Genomics Consortium (IFGC), Momeni P, Sugrue LP, …
• Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer's disease.
  Neurocase 2017 Bonham LW, Sirkis DW, Fan J, Aparicio RE, Tse M, Ramos EM, Wang Q, Coppola G, Rosen HJ, Miller BL, Yokoyama JS
• Genome-wide association study identifies MAPT locus influencing human plasma tau levels.
  Neurology 2017 Chen J, Yu JT, Wojta K, Wang HF, Zetterberg H, Blennow K, Yokoyama JS, Weiner MW, Kramer JH, Rosen H, Miller BL, Coppola G, Boxer AL, Alzheimer's Disease Neuroimaging Initiative
• Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases.
  Journal of neurology, neurosurgery, and psychiatry 2016 Ferrari R, Wang Y, Vandrovcova J, Guelfi S, Witeolar A, Karch CM, Schork AJ, Fan CC, Brewer JB, International FTD-Genomics Consortium (IFGC),, International Parkinson's Disease Genomics Consortium (…
• Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture.
  Neurology(R) neuroimmunology & neuroinflammation 2016 Miller ZA, Sturm VE, Camsari GB, Karydas A, Yokoyama JS, Grinberg LT, Boxer AL, Rosen HJ, Rankin KP, Gorno-Tempini ML, Coppola G, Geschwind DH, Rademakers R, Seeley WW, Graff-Radford NR, Miller BL
• Association of Alzheimer Disease Susceptibility Variants and Gene Expression in the Human Brain-Reply.
  JAMA neurology 2016 Yokoyama JS, Desikan RS
• Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression.
  Acta neuropathologica communications 2016 Sirkis DW, Bonham LW, Aparicio RE, Geier EG, Ramos EM, Wang Q, Karydas A, Miller ZA, Miller BL, Coppola G, Yokoyama JS
• Age-dependent effects of APOE ε4 in preclinical Alzheimer's disease.
  Annals of clinical and translational neurology 2016 Bonham LW, Geier EG, Fan CC, Leong JK, Besser L, Kukull WA, Kornak J, Andreassen OA, Schellenberg GD, Rosen HJ, Dillon WP, Hess CP, Miller BL, Dale AM, Desikan RS, Yokoyama JS
• The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer's disease.
  Acta neuropathologica communications 2016 Bonham LW, Desikan RS, Yokoyama JS, Alzheimer’s Disease Neuroimaging Initiative
• Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease.
  JAMA neurology 2016 Yokoyama JS, Wang Y, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer JB, Franke A, Dillon WP, Wilson DM, Mukherjee P, Hess CP, Miller Z, Bonham LW, Shen…
• Gene-based aggregate SNP associations between candidate AD genes and cognitive decline.
  Age (Dordrecht, Netherlands) 2016 Nettiksimmons J, Tranah G, Evans DS, Yokoyama JS, Yaffe K
• The 5-HTTLPR variant in the serotonin transporter gene modifies degeneration of brain regions important for emotion in behavioral variant frontotemporal dementia.
  NeuroImage. Clinical 2015 Yokoyama JS, Bonham LW, Sturm VE, Adhimoolam B, Karydas A, Coppola G, Miller BL, Rankin KP
• Amyloid in dementia associated with familial FTLD: not an innocent bystander.
  Neurocase 2015 Naasan G, Rabinovici GD, Ghosh P, Elofson JD, Miller BL, Coppola G, Karydas A, Fong J, Perry D, Lee SE, Yokoyama JS, Seeley WW, Kramer JH, Weiner MW, Schuff N, Jagust WJ, Grinberg LT, Pribadi M, Yang …
• Decision tree analysis of genetic risk for clinically heterogeneous Alzheimer's disease.
  BMC neurology 2015 Yokoyama JS, Bonham LW, Sears RL, Klein E, Karydas A, Kramer JH, Miller BL, Coppola G
• Apolipoprotein ε4 is associated with lower brain volume in cognitively normal Chinese but not white older adults.
  PloS one 2015 Yokoyama JS, Lee AK, Takada LT, Busovaca E, Bonham LW, Chao SZ, Tse M, He J, Schwarz CG, Carmichael OT, Matthews BR, Karydas A, Weiner MW, Coppola G, DeCarli CS, Miller BL, Rosen HJ
• Variation in longevity gene KLOTHO is associated with greater cortical volumes.
  Annals of clinical and translational neurology 2015 Yokoyama JS, Sturm VE, Bonham LW, Klein E, Arfanakis K, Yu L, Coppola G, Kramer JH, Bennett DA, Miller BL, Dubal DB
• APOE Genotype Affects Cognitive Training Response in Healthy Shanghai Community-Dwelling Elderly Individuals.
  Journal of Alzheimer's disease : JAD 2015 Feng W, Yokoyama JS, Yu S, Chen Y, Cheng Y, Bonham LW, Wang D, Shen Y, Wu W, Li C
• Damage to left frontal regulatory circuits produces greater positive emotional reactivity in frontotemporal dementia.
  Cortex; a journal devoted to the study of the nervous system and behavior 2014 Sturm VE, Yokoyama JS, Eckart JA, Zakrzewski J, Rosen HJ, Miller BL, Seeley WW, Levenson RW
• Altered network connectivity in frontotemporal dementia with C9orf72 hexanucleotide repeat expansion.
  Brain : a journal of neurology 2014 Lee SE, Khazenzon AM, Trujillo AJ, Guo CC, Yokoyama JS, Sha SJ, Takada LT, Karydas AM, Block NR, Coppola G, Pribadi M, Geschwind DH, Rademakers R, Fong JC, Weiner MW, Boxer AL, Kramer JH, Rosen HJ, …
• The Chinese Verbal Learning Test specifically assesses hippocampal state.
  American journal of Alzheimer's disease and other dementias 2014 Tsai RM, Leong JK, Dutt S, Chang CC, Lee AK, Chao SZ, Yokoyama JS, Tse M, Kramer JH, Miller BL, Rosen HJ
• Life extension factor klotho enhances cognition.
  Cell reports 2014 Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D, Klein E, Yu GQ, Ho K, Eilertson KE, Yu L, Kuro-o M, De Jager PL, Coppola G, Small GW, Bennett DA, Kramer JH, Abraham CR, …
• C9ORF72 hexanucleotide repeats in behavioral and motor neuron disease: clinical heterogeneity and pathological diversity.
  American journal of neurodegenerative disease 2014 Yokoyama JS, Sirkis DW, Miller BL
• Genetic modifiers of cognitive maintenance among older adults.
  Human brain mapping 2014 Yokoyama JS, Evans DS, Coppola G, Kramer JH, Tranah GJ, Yaffe K
• Mitochondrial DNA sequence associations with dementia and amyloid-β in elderly African Americans.
  Neurobiology of aging 2013 Tranah GJ, Yokoyama JS, Katzman SM, Nalls MA, Newman AB, Harris TB, Cesari M, Manini TM, Schork NJ, Cummings SR, Liu Y, Yaffe K, Health, Aging and Body Composition Study
• Depressive symptoms in Chinese-American subjects with cognitive impairment.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2013 Chao SZ, Matthews BR, Yokoyama JS, Lai NB, Ong H, Tse M, Yuan RF, Lin A, Kramer J, Yaffe K, Kornak J, Miller BL, Rosen HJ
• Progranulin mutations as risk factors for Alzheimer disease.
  JAMA neurology 2013 Perry DC, Lehmann M, Yokoyama JS, Karydas A, Lee JJ, Coppola G, Grinberg LT, Geschwind D, Seeley WW, Miller BL, Rosen H, Rabinovici G
• Heightened emotional contagion in mild cognitive impairment and Alzheimer's disease is associated with temporal lobe degeneration.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Sturm VE, Yokoyama JS, Seeley WW, Kramer JH, Miller BL, Rankin KP
• Neuroimaging features of C9ORF72 expansion.
  Alzheimer's research & therapy 2012 Yokoyama JS, Rosen HJ
• Variation in genes related to cochlear biology is strongly associated with adult-onset deafness in border collies.
  PLoS genetics 2012 Yokoyama JS, Lam ET, Ruhe AL, Erdman CA, Robertson KR, Webb AA, Williams DC, Chang ML, Hytönen MK, Lohi H, Hamilton SP, Neff MW
• Frontotemporal dementia in a Brazilian kindred with the c9orf72 mutation.
  Archives of neurology 2012 Takada LT, Pimentel ML, Dejesus-Hernandez M, Fong JC, Yokoyama JS, Karydas A, Thibodeau MP, Rutherford NJ, Baker MC, Lomen-Hoerth C, Rademakers R, Miller BL
• Frontotemporal dementia due to C9ORF72 mutations: clinical and imaging features.
  Neurology 2012 Sha SJ, Takada LT, Rankin KP, Yokoyama JS, Rutherford NJ, Fong JC, Khan B, Karydas A, Baker MC, DeJesus-Hernandez M, Pribadi M, Coppola G, Geschwind DH, Rademakers R, Lee SE, Seeley W, Miller BL, …
• Mitochondrial DNA sequence variation is associated with free-living activity energy expenditure in the elderly.
  Biochimica et biophysica acta 2012 Tranah GJ, Lam ET, Katzman SM, Nalls MA, Zhao Y, Evans DS, Yokoyama JS, Pawlikowska L, Kwok PY, Mooney S, Kritchevsky S, Goodpaster BH, Newman AB, Harris TB, Manini TM, Cummings SR, Health, Aging and …
• Atypical, slowly progressive behavioural variant frontotemporal dementia associated with C9ORF72 hexanucleotide expansion.
  Journal of neurology, neurosurgery, and psychiatry 2012 Khan BK, Yokoyama JS, Takada LT, Sha SJ, Rutherford NJ, Fong JC, Karydas AM, Wu T, Ketelle RS, Baker MC, Hernandez MD, Coppola G, Geschwind DH, Rademakers R, Lee SE, Rosen HJ, Rabinovici GD, Seeley WW…
• Mitochondrial DNA sequence variation associated with dementia and cognitive function in the elderly.
  Journal of Alzheimer's disease : JAD 2012 Tranah GJ, Nalls MA, Katzman SM, Yokoyama JS, Lam ET, Zhao Y, Mooney S, Thomas F, Newman AB, Liu Y, Cummings SR, Harris TB, Yaffe K
• Array-based whole-genome survey of dog saliva DNA yields high quality SNP data.
  PloS one 2010 Yokoyama JS, Erdman CA, Hamilton SP
• A genomewide association study of citalopram response in major depressive disorder.
  Biological psychiatry 2010 Garriock HA, Kraft JB, Shyn SI, Peters EJ, Yokoyama JS, Jenkins GD, Reinalda MS, Slager SL, McGrath PJ, Hamilton SP
• Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.
  Molecular psychiatry 2009 Shyn SI, Shi J, Kraft JB, Potash JB, Knowles JA, Weissman MM, Garriock HA, Yokoyama JS, McGrath PJ, Peters EJ, Scheftner WA, Coryell W, Lawson WB, Jancic D, Gejman PV, Sanders AR, Holmans P, Slager SL…
• Antitumor therapy mediated by 5-fluorocytosine and a recombinant fusion protein containing TSG-6 hyaluronan binding domain and yeast cytosine deaminase.
  Molecular pharmaceutics 2009 Park JI, Cao L, Platt VM, Huang Z, Stull RA, Dy EE, Sperinde JJ, Yokoyama JS, Szoka FC
• Activation of cerebellar parallel fibers monitored in transgenic mice expressing a fluorescent Ca2+ indicator protein.
  The European journal of neuroscience 2005 Díez-García J, Matsushita S, Mutoh H, Nakai J, Ohkura M, Yokoyama J, Dimitrov D, Knöpfel T
• Problems in diagnosis of Hirschsprung's disease by anorectal manometry.
  Progress in pediatric surgery 1989 Yokoyama J, Kuroda T, Matsufugi H, Hirobe S, Hara S, Katsumata K
• [Colostomy in children with special reference to postoperative courses].
  Shujutsu. Operation 1968 Akiyama H, Yokoyama J, Inoue Y, Denda T