Jeni Janci, PhD
Prof. Services Contractor
Emergency Medicine
School of Medicine

Jeni began her life science career in the start-up biotech industry before earning her Ph.D. at University of California, Berkeley in Mike Levine’s laboratory. Her thesis was focused on gene regulatory networks of heart development in the primitive chordate, Ciona intestinalis.

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Directly after her graduate career, she re-entered the life science industry, where at Entelos she provided Quantitative Systems Pharmacology (QSP) Modeling and Simulation services to assist Research & Development for international pharmaceutical companies and other life science applications. Through consulting projects, she applied large-scale, mechanistic systems models to make critical decisions in various stages of the drug discovery and development lifecycle. She was also one of the architects of the novel Hypertension, Renal Failure, and Heart Failure PhysioLab model. Jeni then expanded her work globally on the PhysioLab platforms via training programs and consulting services.

Jeni is excited to help advance UCSF’s world-class research to positively impact people’s health and lives. As the newly hired Program Director, Jeni will manage the diagnostics, digital health and bio-tools tracks for the Catalyst Program.

Education & Training

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• PhD Molecular and Cell Biology University of California, Berkeley 05/2008
• BS Biology Duke University 05/2000

Publications (5)

Top publication keywords:
Renin-Angiotensin SystemFibroblast Growth FactorsBlood PressureCell LineageNotochordGATA Transcription FactorsStem CellsModels, CardiovascularAntihypertensive AgentsBasic Helix-Loop-Helix Transcription FactorsCiona intestinalisForkhead Transcription FactorsHeartEvolution, MolecularCell Movement

• A model-based approach to investigating the pathophysiological mechanisms of hypertension and response to antihypertensive therapies: extending the Guyton model.
  American journal of physiology. Regulatory, integrative and comparative physiology 2014 Hallow KM, Lo A, Beh J, Rodrigo M, Ermakov S, Friedman S, de Leon H, Sarkar A, Xiong Y, Sarangapani R, Schmidt H, Webb R, Kondic AG
• A single GATA factor plays discrete, lineage specific roles in ascidian heart development.
  Developmental biology 2011 Ragkousi K, Beh J, Sweeney S, Starobinska E, Davidson B
• Evolutionary conservation of vertebrate notochord genes in the ascidian Ciona intestinalis.
  Genesis (New York, N.Y. : 2000) 2008 Kugler JE, Passamaneck YJ, Feldman TG, Beh J, Regnier TW, Di Gregorio A
• FoxF is essential for FGF-induced migration of heart progenitor cells in the ascidian Ciona intestinalis.
  Development (Cambridge, England) 2007 Beh J, Shi W, Levine M, Davidson B, Christiaen L
• FGF signaling delineates the cardiac progenitor field in the simple chordate, Ciona intestinalis.
  Genes & development 2006 Davidson B, Shi W, Beh J, Christiaen L, Levine M