Jeffrey Lotz, PhD
Professor
Orthopaedic Surgery
School of Medicine

BACPAC is a translational, patient-centered effort to address the need for effective and personalized therapies for chronic low back pain. Dr. Lotz is also co-director of two other research centers, including the NIDCR-funded Center for Dental, Oral and Craniofacial Tissue and Organ Regeneration (C-DOCTOR, and the NSF-funded Industry/University Cooperative Research Center (CDMI). Dr. Lotz has expertise in spine biomechanics, intervertebral disc biology, and tissue engineering. His laboratory work focuses on identifying mechanisms of disc degeneration, developing novel diagnostics and therapies for low back pain, and the biomechanics of spinal instrumentation. Dr. Lotz earned a doctorate in Medical Engineering from the Harvard/MIT Division of Health Sciences and Technology, a Master's Degree in Mechanical Engineering Design from Stanford University, and a Bachelor of Science in Mechanical Engineering from UC Berkeley.

• Magnetic Resonance Imaging of the Lumbar Spine: Recommendations for Acquisition and Image Evaluation from the BACPAC Spine Imaging Working Group.
  Pain medicine (Malden, Mass.) 2023 Sollmann N, Fields AJ, O'Neill C, Nardo L, Majumdar S, Chin CT, Tosun D, Han M, Vu AT, Ozhinsky E, Shah LM, Harris RE, Lobo R, Anderst W, Herzog R, Psioda MA, Standaert CJ, Price RT, Lotz JC, Link TM,…
• The Back Pain Consortium (BACPAC) Research Program: Structure, Research Priorities, and Methods.
  Pain medicine (Malden, Mass.) 2023 Mauck MC, Lotz J, Psioda MA, Carey TS, Clauw DJ, Majumdar S, Marras WS, Vo N, Aylward A, Hoffmeyer A, Zheng P, Ivanova A, McCumber M, Carson C, Anstrom KJ, Bowden AE, Dalton D, Derr L, Dufour J, …
• Theoretical Schemas to Guide Back Pain Consortium (BACPAC) Chronic Low Back Pain Clinical Research.
  Pain medicine (Malden, Mass.) 2023 Chau A, Steib S, Whitaker E, Kohns D, Quinter A, Craig A, Chiodo A, Chandran S, Laidlaw A, Schott Z, Farlow N, Yarjanian J, Omwanghe A, Wasserman R, O'Neill C, Clauw D, Bowden A, Marras W, Carey T, …
• CAPER: patient preferences to inform nonsurgical treatment of chronic low back pain: a discrete-choice experiment.
  Pain medicine (Malden, Mass.) 2023 Wilson L, Zheng P, Ionova Y, Denham A, Yoo C, Ma Y, Greco CM, Hanmer J, Williams DA, Hassett AL, Scheffler AW, Valone F, Mehling W, Berven S, Lotz J, O'Neill C
• Magnetic resonance spectroscopy (MRS) identification of chemically painful lumbar discs leads to improved 6-, 12-, and 24-month outcomes for discogenic low back pain surgeries.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2023 Gornet MF, Eastlack RK, Peacock J, Schranck FW, Lotz JC
• Multi-domain biopsychosocial postoperative recovery trajectories associate with patient outcomes following lumbar fusion.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2023 Halvorson RT, Torres-Espin A, Callahan M, Tay B, O'Neill C, Berven S, Lotz JC, Bailey JF
• Intradiscal treatment of the cartilage endplate for improving solute transport and disc nutrition.
  Frontiers in bioengineering and biotechnology 2023 Habib M, Hussien S, Jeon O, Lotz JC, Wu PI, Alsberg E, Fields AJ
• ISSLS Prize in Bioengineering Science 2023: Age- and sex-related differences in lumbar intervertebral disc degeneration between patients with chronic low back pain and asymptomatic controls.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2023 Bonnheim NB, Lazar AA, Kumar A, Akkaya Z, Zhou J, Guo X, O'Neill C, Link TM, Lotz JC, Krug R, Fields AJ
• The relative influence of model parameters on finite element analysis simulations of intervertebral body fusion device static compression performance.
  Computer methods in biomechanics and biomedical engineering 2022 Baumann AP, Hsieh MT, Dmitriev AE, Lotz JC
• Magnetic Resonance Imaging Characteristics Associated with Treatment Success from Basivertebral Nerve Ablation: An Aggregated Cohort Study of Multicenter Prospective Clinical Trials Data.
  Pain medicine (Malden, Mass.) 2022 McCormick ZL, Conger A, Smuck M, Lotz JC, Hirsch JA, Hickman C, Harper K, Burnham TR
• Pain Location and Exacerbating Activities Associated with Treatment Success Following Basivertebral Nerve Ablation: An Aggregated Cohort Study of Multicenter Prospective Clinical Trial Data.
  Pain medicine (Malden, Mass.) 2022 McCormick ZL, Sperry BP, Boody BS, Hirsch JA, Conger A, Harper K, Lotz JC, Burnham TR
• Vertebrogenic Pain: A Paradigm Shift in Diagnosis and Treatment of Axial Low Back Pain.
  Pain medicine (Malden, Mass.) 2022 Conger A, Smuck M, Truumees E, Lotz JC, DePalma MJ, McCormick ZL
• Influence of patient-specific factors when comparing multifidus fat infiltration between chronic low back pain patients and asymptomatic controls.
  JOR spine 2022 Ballatori AM, Shahrestani S, Nyayapati P, Agarwal V, Krug R, Han M, Fields AJ, O'Neill C, Demir-Deviren S, Lotz JC, Bailey JF
• Point-of-care motion capture and biomechanical assessment improve clinical utility of dynamic balance testing for lower extremity osteoarthritis.
  PLOS digital health 2022 Halvorson RT, Castillo FT, Ahamed F, Khattab K, Scheffler A, Matthew RP, Lotz J, Vail TP, Feeley BT, Bailey JF
• Spatial distribution of fat infiltration within the paraspinal muscles: implications for chronic low back pain.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2022 Khattab K, Dziesinski LK, Crawford R, Ballatori A, Nyayapati P, Krug R, Fields A, O'Neill CW, Lotz JC, Bailey JF
• Compensatory biomechanics and spinal loading during dynamic maneuvers in patients with chronic low back pain.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2022 Nyayapati P, Booker J, Wu PI, Theologis A, Dziesinski L, O'Neill C, Zheng P, Lotz JC, Matthew RP, Bailey JF
• The contributions of cartilage endplate composition and vertebral bone marrow fat to intervertebral disc degeneration in patients with chronic low back pain.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2022 Bonnheim NB, Wang L, Lazar AA, Zhou J, Chachad R, Sollmann N, Guo X, Iriondo C, O'Neill C, Lotz JC, Link TM, Krug R, Fields AJ
• Unsupervised Machine Learning on Motion Capture Data Uncovers Movement Strategies in Low Back Pain.
  Frontiers in bioengineering and biotechnology 2022 Keller AV, Torres-Espin A, Peterson TA, Booker J, O'Neill C, Lotz JC, Bailey JF, Ferguson AR, Matthew RP
• Using hierarchical unsupervised learning to integrate and reduce multi-level and multi-paraspinal muscle MRI data in relation to low back pain.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2022 Torres-Espin A, Keller A, Johnson GTA, Fields AJ, Krug R, Ferguson AR, Hargens AR, O'Neill CW, Lotz JC, Bailey JF
• Automated assessment and classification of spine, hip, and knee pathologies from sit-to-stand movements collected in clinical practice.
  Journal of biomechanics 2021 Girase H, Nyayapati P, Booker J, Lotz JC, Bailey JF, Matthew RP
• Biomechanical changes in the lumbar spine following spaceflight and factors associated with postspaceflight disc herniation.
  The spine journal : official journal of the North American Spine Society 2021 Bailey JF, Nyayapati P, Johnson GTA, Dziesinski L, Scheffler AW, Crawford R, Scheuring R, O'Neill CW, Chang D, Hargens AR, Lotz JC
• A perspective on the ORS Spine Section initiative to develop a multi-species JOR Spine histopathology series.
  JOR spine 2021 Dahia CL, Engiles JB, Gullbrand SE, Iatridis JC, Lai A, Le Maitre CL, Lotz JC, Masuda K, Séguin CA, Tryfonidou MA
• Development of a standardized histopathology scoring system for human intervertebral disc degeneration: an Orthopaedic Research Society Spine Section Initiative.
  JOR spine 2021 Le Maitre CL, Dahia CL, Giers M, Illien-Junger S, Cicione C, Samartzis D, Vadala G, Fields A, Lotz J
• Paraspinal muscle degeneration and regenerative potential in a Murine model of Lumbar Disc Injury.
  North American Spine Society journal 2021 Davies MR, Kaur G, Liu X, Alvarado FG, Nuthalapati P, Liu M, Diaz A, Lotz JC, Bailey JF, Feeley BT
• Pulsed Electromagnetic Fields Accelerate Sensorimotor Recovery Following Experimental Disc Herniation.
  Spine 2021 Chan AK, Ballatori A, Nyayapati P, Mummaneni NV, Coughlin D, Liebenberg E, Külling FA, Zhang N, Waldorff EI, Ryaby JT, Lotz JC
• Measurement of vertebral endplate bone marrow lesion (Modic change) composition with water-fat MRI and relationship to patient-reported outcome measures.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2021 Fields AJ, Ballatori A, Han M, Bailey JF, McCormick ZL, O'Neill CW, Demir-Deviren S, Krug R, Lotz JC
• Assessing the use of finite element analysis for mechanical performance evaluation of intervertebral body fusion devices.
  JOR spine 2021 Baumann AP, Graf T, Peck JH, Dmitriev AE, Coughlan D, Lotz JC
• Serum biomarkers for Modic changes in patients with chronic low back pain.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2021 Karppinen J, Koivisto K, Ketola J, Haapea M, Paananen M, Herzig KH, Alini M, Lotz J, Dudli S, Samartzis D, Risteli J, Majuri ML, Alenius H, Kyllönen E, Järvinen J, Niinimäki J, Grad S
• In silico feasibility assessment of extracorporeal delivery of low-intensity pulsed ultrasound to intervertebral discs within the lumbar spine.
  Physics in medicine and biology 2020 Adams MS, Lotz JC, Diederich CJ
• Reachable Workspace and Proximal Function Measures for Quantifying Upper Limb Motion.
  IEEE journal of biomedical and health informatics 2020 Matthew RP, Seko S, Kurillo G, Bajcsy R, Cheng L, Han JJ, Lotz J
• FDA public workshop: Orthopaedic sensing, measuring, and advanced reporting technology (SMART) devices.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2020 Baumann AP, O'Neill C, Owens MC, Weber SC, Sivan S, D'Amico R, Carmody S, Bini S, Sawyer AJ, Lotz JC, Goel V, Dmitriev AE
• Magnetic Nanoparticles Synergize with Pulsed Magnetic Fields to Stimulate Osteogenesis In Vitro.
  Tissue engineering. Part A 2020 Habib M, Horne DA, Hussein K, Coughlin D, Waldorff EI, Zhang N, Ryaby JT, Lotz JC
• Automatic Vertebral Body Segmentation Based on Deep Learning of Dixon Images for Bone Marrow Fat Fraction Quantification.
  Frontiers in endocrinology 2020 Zhou J, Damasceno PF, Chachad R, Cheung JR, Ballatori A, Lotz JC, Lazar AA, Link TM, Fields AJ, Krug R
• Serum Biomarkers for Connective Tissue and Basement Membrane Remodeling are Associated with Vertebral Endplate Bone Marrow Lesions as Seen on MRI (Modic Changes).
  International journal of molecular sciences 2020 Dudli S, Ballatori A, Bay-Jensen AC, McCormick ZL, O'Neill CW, Demir-Deviren S, Krug R, Heggli I, Juengel A, Karppinen J, Brunner F, Farshad M, Distler O, Lotz JC, Fields AJ
• LIPUS far-field exposimetry system for uniform stimulation of tissues in-vitro: development and validation with bovine intervertebral disc cells.
  Biomedical physics & engineering express 2020 Horne DA, Jones PD, Adams MS, Lotz JC, Diederich CJ
• The Effect of Parity on Age-Related Degenerative Changes in Sagittal Balance.
  Spine 2020 Bailey JF, Sparrey CJ, Williams FMK, Curran PF, Lotz JC, Kramer PA
• The Effect of Zoledronic Acid on Serum Biomarkers among Patients with Chronic Low Back Pain and Modic Changes in Lumbar Magnetic Resonance Imaging.
  Diagnostics (Basel, Switzerland) 2019 Koivisto K, Karppinen J, Haapea M, Järvinen J, Kyllönen E, Tervonen O, Niinimäki J, Alini M, Lotz J, Dudli S, Samartzis D, Risteli J, Majuri ML, Alenius H, Grad S
• Pulsed electromagnetic fields reduce acute inflammation in the injured rat-tail intervertebral disc.
  JOR spine 2019 Chan AK, Tang X, Mummaneni NV, Coughlin D, Liebenberg E, Ouyang A, Dudli S, Lauricella M, Zhang N, Waldorff EI, Ryaby JT, Lotz JC
• Pulsed Electromagnetic Fields Reduce Interleukin-6 Expression in Intervertebral Disc Cells Via Nuclear Factor-κβ and Mitogen-Activated Protein Kinase p38 Pathways.
  Spine 2019 Tang X, Coughlin D, Ballatori A, Berg-Johansen B, Waldorff EI, Zhang N, Ryaby JT, Aliston T, Lotz JC
• Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis.
  Bone research 2019 Mazur CM, Woo JJ, Yee CS, Fields AJ, Acevedo C, Bailey KN, Kaya S, Fowler TW, Lotz JC, Dang A, Kuo AC, Vail TP, Alliston T
• Measuring and reporting of vertebral endplate bone marrow lesions as seen on MRI (Modic changes): recommendations from the ISSLS Degenerative Spinal Phenotypes Group.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2019 Fields AJ, Battié MC, Herzog RJ, Jarvik JG, Krug R, Link TM, Lotz JC, O'Neill CW, Sharma A, ISSLS Degenerative Spinal Phenotypes Group
• The Relationship Between Endplate Pathology and Patient-reported Symptoms for Chronic Low Back Pain Depends on Lumbar Paraspinal Muscle Quality.
  Spine 2019 Bailey JF, Fields AJ, Ballatori A, Cohen D, Jain D, Coughlin D, O'Neill C, McCormick Z, Han M, Krug R, Demir-Deviren S, Lotz JC
• Functional workspace and patient-reported outcomes improve after reverse and total shoulder arthroplasty.
  Journal of shoulder and elbow surgery 2019 Ngan A, Xiao W, Curran PF, Tseng WJ, Hung LW, Nguyen C, Matthew R, Ma B, Lotz J, Feeley BT
• Simple Spline Representation for Identifying Sit-to-Stand Strategies.
  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2019 Matthew RP, Seko S, Bailey J, Bajcsy R, Lotz J
• Matrix modification for enhancing the transport properties of the human cartilage endplate to improve disc nutrition.
  PloS one 2019 Dolor A, Sampson SL, Lazar AA, Lotz JC, Szoka FC, Fields AJ
• ISSLS PRIZE IN BIOENGINEERING SCIENCE 2019: biomechanical changes in dynamic sagittal balance and lower limb compensatory strategies following realignment surgery in adult spinal deformity patients.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2019 Bailey JF, Matthew RP, Seko S, Curran P, Chu L, Berven SH, Deviren V, Burch S, Lotz JC
• Estimating Sit-to-Stand Dynamics Using a Single Depth Camera.
  IEEE journal of biomedical and health informatics 2019 Matthew RP, Seko S, Bailey J, Bajcsy R, Lotz J
• Nutrient supply and nucleus pulposus cell function: effects of the transport properties of the cartilage endplate and potential implications for intradiscal biologic therapy.
  Osteoarthritis and cartilage 2019 Wong J, Sampson SL, Bell-Briones H, Ouyang A, Lazar AA, Lotz JC, Fields AJ
• Associations between vertebral body fat fraction and intervertebral disc biochemical composition as assessed by quantitative MRI.
  Journal of magnetic resonance imaging : JMRI 2019 Krug R, Joseph GB, Han M, Fields A, Cheung J, Mundada M, Bailey J, Rochette A, Ballatori A, McCulloch CE, McCormick Z, O'Neill C, Link TM, Lotz J
• Magnetic resonance spectroscopy (MRS) can identify painful lumbar discs and may facilitate improved clinical outcomes of lumbar surgeries for discogenic pain.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2019 Gornet MG, Peacock J, Claude J, Schranck FW, Copay AG, Eastlack RK, Benz R, Olshen A, Lotz JC
• Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic: Recommendations of the ORS spine section.
  JOR spine 2018 Smith LJ, Silverman L, Sakai D, Le Maitre CL, Mauck RL, Malhotra NR, Lotz JC, Buckley CT
• Kinematic and Kinetic Validation of an Improved Depth Camera Motion Assessment System Using Rigid Bodies.
  IEEE journal of biomedical and health informatics 2018 Matthew RP, Seko S, Bajcsy R, Lotz J
• Contribution of the endplates to disc degeneration.
  Current molecular biology reports 2018 Fields AJ, Ballatori A, Liebenberg EC, Lotz JC
• Tidemark Avulsions are a Predominant Form of Endplate Irregularity.
  Spine 2018 Berg-Johansen B, Jain D, Liebenberg EC, Fields AJ, Link TM, O'Neill CW, Lotz JC
• A functional method for generating individualized spine models from motion-capture data.
  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2018 Seko S, Matthew RP, Bajcsy R, Lotz JC
• Tracking Kinematic and Kinetic Measures of Sit to Stand using an Instrumented Spine Orthosis.
  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2018 Matthew RP, Seko S, Bailey J, Bajcsy R, Lotz J
• Quantification of Propionic Acid in the Bovine Spinal Disk After Infection of the Tissue With Propionibacteria acnes Bacteria.
  Spine 2018 Magnitsky S, Dudli S, Tang X, Kaur J, Diaz J, Miller S, Lotz JC
• Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration.
  Spine 2018 Berg-Johansen B, Han M, Fields AJ, Liebenberg EC, Lim BJ, Larson PE, Gunduz-Demir C, Kazakia GJ, Krug R, Lotz JC
• Dental, Oral, and Craniofacial Regenerative Medicine: Transforming Biotechnologies for Innovating Patient Care.
  Journal of dental research 2018 Giannobile WV, Chai Y, Chen Y, Healy KE, Klein O, Lane N, Longaker MT, Lotz JC, Mooney DJ, Sfeir CS, Urata M, Wagner WR, Wu BM, Kohn DH
• Modic type 1 change is an autoimmune response that requires a proinflammatory milieu provided by the 'Modic disc'.
  The spine journal : official journal of the North American Spine Society 2017 Dudli S, Liebenberg E, Magnitsky S, Lu B, Lauricella M, Lotz JC
• Dynamic imaging demonstrates that pulsed electromagnetic fields (PEMF) suppress IL-6 transcription in bovine nucleus pulposus cells.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2017 Tang X, Alliston T, Coughlin D, Miller S, Zhang N, Waldorff EI, Ryaby JT, Lotz JC
• From the international space station to the clinic: how prolonged unloading may disrupt lumbar spine stability.
  The spine journal : official journal of the North American Spine Society 2017 Bailey JF, Miller SL, Khieu K, O'Neill CW, Healey RM, Coughlin DG, Sayson JV, Chang DG, Hargens AR, Lotz JC
• Structural vertebral endplate nomenclature and etiology: a study by the ISSLS Spinal Phenotype Focus Group.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2017 Zehra U, Bow C, Lotz JC, Williams FMK, Rajasekaran S, Karppinen J, Luk KDK, C Battiê M, Samartzis D
• Inflammatory response of disc cells against Propionibacterium acnes depends on the presence of lumbar Modic changes.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2017 Dudli S, Miller S, Demir-Deviren S, Lotz JC
• A Kinect-based movement assessment system: marker position comparison to Vicon.
  Computer methods in biomechanics and biomedical engineering 2017 Nichols JK, Sena MP, Hu JL, O'Reilly OM, Feeley BT, Lotz JC
• Structure-function relationships at the human spinal disc-vertebra interface.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2017 Berg-Johansen B, Fields AJ, Liebenberg EC, Li A, Lotz JC
• Role of Osteoblast Gi Signaling in Age-Related Bone Loss in Female Mice.
  Endocrinology 2017 Millard SM, Wang L, Wattanachanya L, O'Carroll D, Fields AJ, Pang J, Kazakia G, Lotz JC, Nissenson RA
• Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis.
  Scientific reports 2017 Fowler TW, Acevedo C, Mazur CM, Hall-Glenn F, Fields AJ, Bale HA, Ritchie RO, Lotz JC, Vail TP, Alliston T
• Low intensity pulsed ultrasound (LIPUS) for the treatment of intervertebral disc degeneration.
  Proceedings of SPIE--the International Society for Optical Engineering 2017 Horne D, Jones P, Salgaonkar V, Adams M, Ozilgen BA, Zahos P, Tang X, Liebenburg E, Coughlin D, Lotz J, Diederich C
• Mechanical performance of cervical intervertebral body fusion devices: A systematic analysis of data submitted to the Food and Drug Administration.
  Journal of biomechanics 2017 Peck JH, Sing DC, Nagaraja S, Peck DG, Lotz JC, Dmitriev AE
• ISSLS PRIZE IN BASIC SCIENCE 2017: Intervertebral disc/bone marrow cross-talk with Modic changes.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2017 Dudli S, Sing DC, Hu SS, Berven SH, Burch S, Deviren V, Cheng I, Tay BKB, Alamin TF, Ith MAM, Pietras EM, Lotz JC
• Lumbar Spine Paraspinal Muscle and Intervertebral Disc Height Changes in Astronauts After Long-Duration Spaceflight on the International Space Station.
  Spine 2016 Chang DG, Healey RM, Snyder AJ, Sayson JV, Macias BR, Coughlin DG, Bailey JF, Parazynski SE, Lotz JC, Hargens AR
• Effects of cell type and configuration on anabolic and catabolic activity in 3D co-culture of mesenchymal stem cells and nucleus pulposus cells.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2016 Ouyang A, Cerchiari AE, Tang X, Liebenberg E, Alliston T, Gartner ZJ, Lotz JC
• Propionibacterium acnes infected intervertebral discs cause vertebral bone marrow lesions consistent with Modic changes.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2016 Dudli S, Liebenberg E, Magnitsky S, Miller S, Demir-Deviren S, Lotz JC
• Implantation of juvenile human chondrocytes demonstrates no adverse effect on spinal nerve tissue in rats.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2016 Külling FA, Liu JJ, Liebenberg E, Lotz JC
• Pathobiology of Modic changes.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2016 Dudli S, Fields AJ, Samartzis D, Karppinen J, Lotz JC
• Pulsed electromagnetic field (PEMF) treatment reduces expression of genes associated with disc degeneration in human intervertebral disc cells.
  The spine journal : official journal of the North American Spine Society 2016 Miller SL, Coughlin DG, Waldorff EI, Ryaby JT, Lotz JC
• The effect of simulated microgravity on lumbar spine biomechanics: an in vitro study.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2015 Laws CJ, Berg-Johansen B, Hargens AR, Lotz JC
• A mechanical pivot-shift device for continuously applying defined loads to cadaveric knees.
  Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 2015 Sena MP, DellaMaggioria R, Lotz JC, Feeley BT
• Novel diagnostic and prognostic methods for disc degeneration and low back pain.
  The spine journal : official journal of the North American Spine Society 2015 Samartzis D, Borthakur A, Belfer I, Bow C, Lotz JC, Wang HQ, Cheung KM, Carragee E, Karppinen J
• Spaceflight-induced bone loss alters failure mode and reduces bending strength in murine spinal segments.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2015 Berg-Johansen B, Liebenberg EC, Li A, Macias BR, Hargens AR, Lotz JC
• Cardiovascular magnetic resonance feature-tracking assessment of myocardial mechanics: Intervendor agreement and considerations regarding reproducibility.
  Clinical radiology 2015 Schuster A, Stahnke VC, Unterberg-Buchwald C, Kowallick JT, Lamata P, Steinmetz M, Kutty S, Fasshauer M, Staab W, Sohns JM, Bigalke B, Ritter C, Hasenfuß G, Beerbaum P, Lotz J
• Neural innervation patterns in the sacral vertebral body.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2015 Degmetich S, Bailey JF, Liebenberg E, Lotz JC
• Tibiofemoral contact pressures in radial tears of the meniscus treated with all-inside repair, inside-out repair and partial meniscectomy.
  The Knee 2015 Zhang AL, Miller SL, Coughlin DG, Lotz JC, Feeley BT
• Osteoclast activators are elevated in intervertebral disks with Modic changes among patients operated for herniated nucleus pulposus.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2015 Torkki M, Majuri ML, Wolff H, Koskelainen T, Haapea M, Niinimäki J, Alenius H, Lotz J, Karppinen J
• Alterations in intervertebral disc composition, matrix homeostasis and biomechanical behavior in the UCD-T2DM rat model of type 2 diabetes.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2015 Fields AJ, Berg-Johansen B, Metz LN, Miller S, La B, Liebenberg EC, Coughlin DG, Graham JL, Stanhope KL, Havel PJ, Lotz JC
• Cartilaginous end plates: Quantitative MR imaging with very short echo times-orientation dependence and correlation with biochemical composition.
  Radiology 2014 Fields AJ, Han M, Krug R, Lotz JC
• Drug-induced changes to the vertebral endplate vasculature affect transport into the intervertebral disc in vivo.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2014 Gullbrand SE, Peterson J, Mastropolo R, Lawrence JP, Lopes L, Lotz J, Ledet EH
• Real-time phase-contrast flow MRI of the ascending aorta and superior vena cava as a function of intrathoracic pressure (Valsalva manoeuvre).
  The British journal of radiology 2014 Kowallick JT, Joseph AA, Unterberg-Buchwald C, Fasshauer M, van Wijk K, Merboldt KD, Voit D, Frahm J, Lotz J, Sohns JM
• Effect of microgravity on the biomechanical properties of lumbar and caudal intervertebral discs in mice.
  Journal of biomechanics 2014 Bailey JF, Hargens AR, Cheng KK, Lotz JC
• Comparison of vertebral and intervertebral disc lesions in aging humans and rhesus monkeys.
  Osteoarthritis and cartilage 2014 Bailey JF, Fields AJ, Liebenberg E, Mattison JA, Lotz JC, Kramer PA
• The anabolic effect of plasma-mediated ablation on the intervertebral disc: stimulation of proteoglycan and interleukin-8 production.
  The spine journal : official journal of the North American Spine Society 2014 Kuelling FA, Foley KT, Liu JJ, Liebenberg E, Sin AH, Matsukawa A, Lotz JC
• Influence of biochemical composition on endplate cartilage tensile properties in the human lumbar spine.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2013 Fields AJ, Rodriguez D, Gary KN, Liebenberg EC, Lotz JC
• Intervertebral discs from spinal nondeformity and deformity patients have different mechanical and matrix properties.
  The spine journal : official journal of the North American Spine Society 2013 Cheng KK, Berven SH, Hu SS, Lotz JC
• On representations for joint moments using a joint coordinate system.
  Journal of biomechanical engineering 2013 O'Reilly OM, Sena MP, Feeley BT, Lotz JC
• Innervation of pathologies in the lumbar vertebral end plate and intervertebral disc.
  The spine journal : official journal of the North American Spine Society 2013 Fields AJ, Liebenberg EC, Lotz JC
• Disk degeneration and low back pain: are they fat-related conditions?
  Global spine journal 2013 Samartzis D, Karppinen J, Cheung JP, Lotz J
• The role of the vertebral end plate in low back pain.
  Global spine journal 2013 Lotz JC, Fields AJ, Liebenberg EC
• Dynamic evaluation of pivot-shift kinematics in physeal-sparing pediatric anterior cruciate ligament reconstruction techniques.
  The American journal of sports medicine 2013 Sena M, Chen J, Dellamaggioria R, Coughlin DG, Lotz JC, Feeley BT
• Seeing double: a comparison of microstructure, biomechanical function, and adjacent disc health between double- and single-layer vertebral endplates.
  Spine 2012 Fields AJ, Sahli F, Rodriguez AG, Lotz JC
• New treatments and imaging strategies in degenerative disease of the intervertebral disks.
  Radiology 2012 Lotz JC, Haughton V, Boden SD, An HS, Kang JD, Masuda K, Freemont A, Berven S, Sengupta DK, Tanenbaum L, Maurer P, Ranganathan A, Alavi A, Marinelli NL
• Direct lateral approach to lumbar fusion is a biomechanically equivalent alternative to the anterior approach: an in vitro study.
  Spine 2012 Laws CJ, Coughlin DG, Lotz JC, Serhan HA, Hu SS
• Structured bilaminar coculture outperforms stem cells and disc cells in a simulated degenerate disc environment.
  Spine 2012 Allon AA, Butcher K, Schneider RA, Lotz JC
• [Consensus recommendations of the German Radiology Society (DRG), the German Cardiac Society (DGK) and the German Society for Pediatric Cardiology (DGPK) on the use of cardiac imaging with computed tomography and magnetic resonance imaging].
  RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 2012 Achenbach S, Barkhausen J, Beer M, Beerbaum P, Dill T, Eichhorn J, Fratz S, Gutberlet M, Hoffmann M, Huber A, Hunold P, Klein C, Krombach G, Kreitner KF, Kühne T, Lotz J, Maintz D, Mahrholdt H, …
• Structured coculture of mesenchymal stem cells and disc cells enhances differentiation and proliferation.
  Cells, tissues, organs 2012 Allon AA, Butcher K, Schneider RA, Lotz JC
• Porcine intervertebral disc repair using allogeneic juvenile articular chondrocytes or mesenchymal stem cells.
  Tissue engineering. Part A 2011 Acosta FL, Metz L, Adkisson HD, Liu J, Carruthers-Liebenberg E, Milliman C, Maloney M, Lotz JC
• Biological and biomechanical effects of fibrin injection into porcine intervertebral discs.
  Spine 2011 Buser Z, Kuelling F, Liu J, Liebenberg E, Thorne KJ, Coughlin D, Lotz JC
• Morphology of the human vertebral endplate.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2011 Rodriguez AG, Rodriguez-Soto AE, Burghardt AJ, Berven S, Majumdar S, Lotz JC
• Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy.
  Osteoarthritis and cartilage 2011 Cooke ME, Allon AA, Cheng T, Kuo AC, Kim HT, Vail TP, Marcucio RS, Schneider RA, Lotz JC, Alliston T
• Human disc nucleus properties and vertebral endplate permeability.
  Spine 2011 Rodriguez AG, Slichter CK, Acosta FL, Rodriguez-Soto AE, Burghardt AJ, Majumdar S, Lotz JC
• A musculoskeletal model for the lumbar spine.
  Biomechanics and modeling in mechanobiology 2011 Christophy M, Faruk Senan NA, Lotz JC, O'Reilly OM
• Biomechanical evaluation of pediatric anterior cruciate ligament reconstruction techniques.
  The American journal of sports medicine 2011 Kennedy A, Coughlin DG, Metzger MF, Tang R, Pearle AD, Lotz JC, Feeley BT
• Innervation patterns of PGP 9.5-positive nerve fibers within the human lumbar vertebra.
  Journal of anatomy 2011 Bailey JF, Liebenberg E, Degmetich S, Lotz JC
• Load and the spine. How does the Goldilocks principle apply?
  The spine journal : official journal of the North American Spine Society 2011 Lotz JC
• [An introduction to the cardiac and vascular diagnostics team].
  RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 2010 Miller S, Gutberlet M, Lotz J, Fischbach R, Barkhausen J
• Structured coculture of stem cells and disc cells prevent disc degeneration in a rat model.
  The spine journal : official journal of the North American Spine Society 2010 Allon AA, Aurouer N, Yoo BB, Liebenberg EC, Buser Z, Lotz JC
• Minimizing errors associated with calculating the location of the helical axis for spinal motions.
  Journal of biomechanics 2010 Metzger MF, Faruk Senan NA, O'Reilly OM, Lotz JC
• Antithrombogenic modification of small-diameter microfibrous vascular grafts.
  Arteriosclerosis, thrombosis, and vascular biology 2010 Hashi CK, Derugin N, Janairo RR, Lee R, Schultz D, Lotz J, Li S
• Pure moment testing for spinal biomechanics applications: Fixed versus sliding ring cable-driven test designs.
  Journal of biomechanics 2010 Eguizabal J, Tufaga M, Scheer JK, Ames C, Lotz JC, Buckley JM
• New challenges for intervertebral disc treatment using regenerative medicine.
  Tissue engineering. Part B, Reviews 2010 Masuda K, Lotz JC
• Trials of vertebroplasty for vertebral fractures.
  The New England journal of medicine 2009 Lotz JC
• On the stiffness matrix of the intervertebral joint: application to total disk replacement.
  Journal of biomechanical engineering 2009 O'Reilly OM, Metzger MF, Buckley JM, Moody DA, Lotz JC
• [Recommendations for utilizing computerized tomography and magnetic resonance tomography in heart diagnosis. 2--Magnetic resonance tomography ].
  RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 2009 Lotz J, Kivelitz D, Fischbach R, Beer M, Miller S
• The influence of ferucarbotran on the chondrogenesis of human mesenchymal stem cells.
  Contrast media & molecular imaging 2009 Henning TD, Sutton EJ, Kim A, Golovko D, Horvai A, Ackerman L, Sennino B, McDonald D, Lotz J, Daldrup-Link HE
• [Recommendations of the Heart Diagnosis Working Group of the German Roentgen Society for use of computerized tomography and magnetic resonance tomography in heart diagnosis. 1-- Computerized tomography].
  RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 2009 Fischbach R, Miller S, Beer M, Lotz J, Kivelitz D
• Co-culture of Adult Mesenchymal Stem Cells and Nucleus Pulposus Cells in Bilaminar Pellets for Intervertebral Disc Regeneration.
  SAS journal 2009 Allon AA, Schneider RA, Lotz JC
• The tissue diagnostic instrument.
  The Review of scientific instruments 2009 Hansma P, Yu H, Schultz D, Rodriguez A, Yurtsev EA, Orr J, Tang S, Miller J, Wallace J, Zok F, Li C, Souza R, Proctor A, Brimer D, Nogues-Solan X, Mellbovsky L, Peña MJ, Diez-Ferrer O, Mathews P, …
• Mechanical profiling of intervertebral discs.
  Journal of biomechanics 2009 Schultz DS, Rodriguez AG, Hansma PK, Lotz JC
• Multiple differentiation capacity of STRO-1+/CD146+ PDL mesenchymal progenitor cells.
  Stem cells and development 2009 Xu J, Wang W, Kapila Y, Lotz J, Kapila S
• Pressure and distortion regulate human mesenchymal stem cell gene expression.
  Annals of biomedical engineering 2009 Haudenschild AK, Hsieh AH, Kapila S, Lotz JC
• Biomechanical pullout strength and stability of the cervical artificial pedicle screw.
  Spine 2009 Barnes AH, Eguizabal JA, Acosta FL, Lotz JC, Buckley JM, Ames CP
• Quantifying the contributions of structure to the annulus fibrosus mechanical function using a nonlinear, anisotropic, hyperelastic model.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2008 Wagner DR, Lotz JC
• Detection of postoperative granulation tissue with an ICG-enhanced integrated OI-/X-ray System.
  Journal of translational medicine 2008 Meier R, Boddington S, Krug C, Acosta FL, Thullier D, Henning TD, Sutton EJ, Tavri S, Lotz JC, Daldrup-Link HE
• Anulus fibrosus tension inhibits degenerative structural changes in lamellar collagen.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2008 Lotz JC, Hadi T, Bratton C, Reiser KM, Hsieh AH
• Structural factors that mediate scleral stiffness.
  Investigative ophthalmology & visual science 2008 Schultz DS, Lotz JC, Lee SM, Trinidad ML, Stewart JM
• Chondrogenic differentiation of human mesenchymal stem cells in three-dimensional alginate gels.
  Tissue engineering. Part A 2008 Xu J, Wang W, Ludeman M, Cheng K, Hayami T, Lotz JC, Kapila S
• Biomechanical comparison of three fixation techniques for unstable thoracolumbar burst fractures. Laboratory investigation.
  Journal of neurosurgery. Spine 2008 Acosta FL, Buckley JM, Xu Z, Lotz JC, Ames CP
• Lactic acid and proteoglycans as metabolic markers for discogenic back pain.
  Spine 2008 Keshari KR, Lotz JC, Link TM, Hu S, Majumdar S, Kurhanewicz J
• ISSLS prize winner: repeated disc injury causes persistent inflammation.
  Spine 2007 Ulrich JA, Liebenberg EC, Thuillier DU, Lotz JC
• Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration.
  PloS one 2007 Behonick DJ, Xing Z, Lieu S, Buckley JM, Lotz JC, Marcucio RS, Werb Z, Miclau T, Colnot C
• Quantitative analysis of structural disorder in intervertebral disks using second harmonic generation imaging: comparison with morphometric analysis.
  Journal of biomedical optics 2007 Reiser KM, Bratton C, Yankelevich DR, Knoesen A, Rocha-Mendoza I, Lotz J
• Biological and mechanical consequences of transient intervertebral disc bending.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2007 Court C, Chin JR, Liebenberg E, Colliou OK, Lotz JC
• Relationship between femoral head size and distance to lesser trochanter.
  Clinical orthopaedics and related research 2007 Sproul RC, Reynolds HM, Lotz JC, Ries MD
• In vitro system for applying cyclic loads to connective tissues under displacement or force control.
  Annals of biomedical engineering 2007 Asundi KR, Kursa K, Lotz J, Rempel DM
• Intradiscal thermal therapy using interstitial ultrasound: an in vivo investigation in ovine cervical spine.
  Spine 2007 Nau WH, Diederich CJ, Shu R, Kinsey A, Bass E, Lotz J, Hu S, Simko J, Ferrier W, Sutton J, Attawia M, Pellegrino R
• The short-term effects of electrosurgical ablation on proinflammatory mediator production by intervertebral disc cells in tissue culture.
  The spine journal : official journal of the North American Spine Society 2007 Rhyu KW, Walsh AJ, O'Neill CW, Bradford DS, Lotz JC
• Glucosamine HCl alters production of inflammatory mediators by rat intervertebral disc cells in vitro.
  The spine journal : official journal of the North American Spine Society 2007 Walsh AJ, O'neill CW, Lotz JC
• Stab incision for inducing intervertebral disc degeneration in the rat.
  Spine 2007 Rousseau MA, Ulrich JA, Bass EC, Rodriguez AG, Liu JJ, Lotz JC
• Innervation, inflammation, and hypermobility may characterize pathologic disc degeneration: review of animal model data.
  The Journal of bone and joint surgery. American volume 2006 Lotz JC, Ulrich JA
• Intradiscal thermal therapy does not stimulate biologic remodeling in an in vivo sheep model.
  Spine 2006 Bass EC, Nau WH, Diederich CJ, Liebenberg E, Shu R, Pellegrino R, Sutton J, Attawia M, Hu SS, Ferrier WT, Lotz JC
• Glycation increases human annulus fibrosus stiffness in both experimental measurements and theoretical predictions.
  Journal of biomechanics 2006 Wagner DR, Reiser KM, Lotz JC
• Correlation of HR-MAS spectroscopy derived metabolite concentrations with collagen and proteoglycan levels and Thompson grade in the degenerative disc.
  Spine 2005 Keshari KR, Lotz JC, Kurhanewicz J, Majumdar S
• Dependence of mechanical behavior of the murine tail disc on regional material properties: a parametric finite element study.
  Journal of biomechanical engineering 2005 Hsieh AH, Wagner DR, Cheng LY, Lotz JC
• Disc regeneration: why, when, and how.
  Neurosurgery clinics of North America 2005 Lotz JC, Kim AJ
• The potential role of mesenchymal stem cell therapy for intervertebral disc degeneration: a critical overview.
  Neurosurgical focus 2005 Acosta FL, Lotz J, Ames CP
• Basic fibroblast growth factor improves trabecular bone connectivity and bone strength in the lumbar vertebral body of osteopenic rats.
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2005 Yao W, Hadi T, Jiang Y, Lotz J, Wronski TJ, Lane NE
• Characterization of intervertebral disc degeneration by high-resolution magic angle spinning (HR-MAS) spectroscopy.
  Magnetic resonance in medicine 2005 Keshari KR, Zektzer AS, Swanson MG, Majumdar S, Lotz JC, Kurhanewicz J
• Effects of controlled dynamic disc distraction on degenerated intervertebral discs: an in vivo study on the rabbit lumbar spine model.
  Spine 2005 Kroeber M, Unglaub F, Guehring T, Guegring T, Nerlich A, Hadi T, Lotz J, Carstens C
• Carpal tunnel pressure alters median nerve function in a dose-dependent manner: a rabbit model for carpal tunnel syndrome.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2005 Diao E, Shao F, Liebenberg E, Rempel D, Lotz JC
• The effect on anterior column loading due to different vertebral augmentation techniques.
  Clinical biomechanics (Bristol, Avon) 2005 Ananthakrishnan D, Berven S, Deviren V, Cheng K, Lotz JC, Xu Z, Puttlitz CM
• Intervertebral disc replacement maintains cervical spine kinetics.
  Spine 2004 Puttlitz CM, Rousseau MA, Xu Z, Hu S, Tay BK, Lotz JC
• Animal models of intervertebral disc degeneration: lessons learned.
  Spine 2004 Lotz JC
• Introduction: disc degeneration: summary.
  Spine 2004 An HS, Anderson PA, Haughton VM, Iatridis JC, Kang JD, Lotz JC, Natarajan RN, Oegema TR, Roughley P, Setton LA, Urban JP, Videman T, Andersson GB, Weinstein JN
• A phase IIA study of the topoisomerase I inhibitor, exatecan mesylate (DX-8951f), administered at two different dose schedules in patients with platinum- and taxane-resistant/refractory ovarian cancer.
  Gynecologic oncology 2004 Clamp A, Adams M, Atkinson R, Boven E, Calvert AH, Cervantes A, Ganesan T, Lotz J, Vasey P, Cheverton P, Jayson GC
• Biaxial testing of human annulus fibrosus and its implications for a constitutive formulation.
  Annals of biomedical engineering 2004 Bass EC, Ashford FA, Segal MR, Lotz JC
• Diffraction enhanced imaging of articular cartilage and comparison with micro-computed tomography of the underlying bone structure.
  European radiology 2004 Majumdar S, Issever AS, Burghardt A, Lotz J, Arfelli F, Rigon L, Heitner G, Menk RH
• Theoretical model and experimental results for the nonlinear elastic behavior of human annulus fibrosus.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2004 Wagner DR, Lotz JC
• Ventral approach to the lumbar spine of the Sprague-Dawley rat.
  Lab animal 2004 Rousseau MA, Bass EC, Lotz JC
• Biomechanics of cervical laminoplasty: kinetic studies comparing different surgical techniques, temporal effects and the degree of level involvement.
  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2004 Puttlitz CM, Deviren V, Smith JA, Kleinstueck FS, Tran QN, Thurlow RW, Eisele P, Lotz JC
• A three-dimensional MRI analysis of knee kinematics.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2004 Patel VV, Hall K, Ries M, Lotz J, Ozhinsky E, Lindsey C, Lu Y, Majumdar S
• Biological response of the intervertebral disc to dynamic loading.
  Journal of biomechanics 2004 Walsh AJ, Lotz JC
• Intervertebral disc cell therapy for regeneration: mesenchymal stem cell implantation in rat intervertebral discs.
  Annals of biomedical engineering 2004 Crevensten G, Walsh AJ, Ananthakrishnan D, Page P, Wahba GM, Lotz JC, Berven S
• Intervertebral disc degeneration: the role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload.
  The American journal of pathology 2004 Rannou F, Lee TS, Zhou RH, Chin J, Lotz JC, Mayoux-Benhamou MA, Barbet JP, Chevrot A, Shyy JY
• Stability analysis of craniovertebral junction fixation techniques.
  The Journal of bone and joint surgery. American volume 2004 Puttlitz CM, Melcher RP, Kleinstueck FS, Harms J, Bradford DS, Lotz JC
• Heat-induced changes in porcine annulus fibrosus biomechanics.
  Journal of biomechanics 2004 Bass EC, Wistrom EV, Diederich CJ, Nau WH, Pellegrino R, Ruberti J, Lotz JC
• In vivo growth factor treatment of degenerated intervertebral discs.
  Spine 2004 Walsh AJ, Bradford DS, Lotz JC
• Mechanobiology in intervertebral disc degeneration and regeneration.
  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2004 Lotz JC, Staples A, Walsh A, Hsieh AH
• Percutaneous plasma decompression alters cytokine expression in injured porcine intervertebral discs.
  The spine journal : official journal of the North American Spine Society 2004 O'Neill CW, Liu JJ, Leibenberg E, Hu SS, Deviren V, Tay BK, Chin CT, Lotz JC
• Polarization-modulated second harmonic generation imaging: method for quantitative assessment of disorganization in anulus.
  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2004 Reiser KM, Rocha-Mendoza I, Wang M, Yankelevich DR, Bratton C, Knoesen A, Lotz JC, Liebenman E
• The compressive creep properties of normal and degenerated murine intervertebral discs.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2004 Palmer EI, Lotz JC
• Prolonged spinal loading induces matrix metalloproteinase-2 activation in intervertebral discs.
  Spine 2003 Hsieh AH, Lotz JC
• Temperature and thermal dose distributions during intradiscal electrothermal therapy in the cadaveric lumbar spine.
  Spine 2003 Kleinstueck FS, Diederich CJ, Nau WH, Puttlitz CM, Smith JA, Bradford DS, Lotz JC
• Dorsal and palmar material properties of the adult human flexor profundus tendon in Zone II.
  Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand 2003 Soejima O, Diao E, Lotz JC, Hariharan JS, Naito M
• Effect of cementless bowed stem distal surface contour and coronal slot on femoral bone strains and torsional stability.
  The Journal of arthroplasty 2003 Ries MD, Suzuki Y, Renowitzky G, Lotz JC, Barrack RL, Bourne RB, Rorabeck CH
• Scaphoid kinematic behavior after division of the transverse carpal ligament.
  The Journal of hand surgery 2003 Ishiko T, Puttlitz CM, Lotz JC, Diao E
• Micro-computed tomography evaluation of trabecular bone structure on loaded mice tail vertebrae.
  Spine 2003 Issever AS, Walsh A, Lu Y, Burghardt A, Lotz JC, Majumdar S
• The effects of synthetic conjugated estrogens, a (cenestin) on trabecular bone structure and strength in the ovariectomized rat model.
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2002 Lane NE, Kumer JL, Majumdar S, Khan M, Lotz J, Stevens RE, Klein R, Phelps KV
• The internal mechanics of the intervertebral disc under cyclic loading.
  Journal of biomechanics 2002 Riches PE, Dhillon N, Lotz J, Woods AW, McNally DS
• [Biomechanical properties of bioabsorbable cannulated screws for surgical fixation of dislocated epiphysiolysis capitis femoris].
  Der Orthopade 2002 Kröber MW, Rovinsky D, Lotz J, Carstens C, Otsuka NY
• Impact biomechanics and pelvic deformation during insertion of press-fit acetabular cups.
  The Journal of arthroplasty 2002 Kroeber M, Ries MD, Suzuki Y, Renowitzky G, Ashford F, Lotz J
• Tenascin-X deficiency mimics Ehlers-Danlos syndrome in mice through alteration of collagen deposition.
  Nature genetics 2002 Mao JR, Taylor G, Dean WB, Wagner DR, Afzal V, Lotz JC, Rubin EM, Bristow J
• Magnetic resonance imaging measurement of relaxation and water diffusion in the human lumbar intervertebral disc under compression in vitro.
  Spine 2001 Chiu EJ, Newitt DC, Segal MR, Hu SS, Lotz JC, Majumdar S
• Postoperative reduction of fibrinolysis as a prognostic factor of fatal outcome.
  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2001 Lotz J, Walgenbach S, Peetz D, Dutkowski P, Junginger T, Prellwitz W, Hafner G
• The effect of static in vivo bending on the murine intervertebral disc.
  The spine journal : official journal of the North American Spine Society 2001 Court C, Colliou OK, Chin JR, Liebenberg E, Bradford DS, Lotz JC
• Effect of frozen storage on the creep behavior of human intervertebral discs.
  Spine 2001 Dhillon N, Bass EC, Lotz JC
• [Effects of early estrogen replacement therapy on bone stability of ovariectomized rats. A biomechanical and radiologic study of the tibial plateau].
  Der Orthopade 2000 Kröber MW, Lane N, Lotz JC, Thomsen M
• Biphasic material properties of lytic bone metastases.
  Annals of biomedical engineering 2000 Whyne CM, Hu SS, Workman KL, Lotz JC
• Intervertebral disc cell death is dependent on the magnitude and duration of spinal loading.
  Spine 2000 Lotz JC, Chin JR
• Anisotropic shear behavior of the annulus fibrosus: effect of harvest site and tissue prestrain.
  Medical engineering & physics 2000 Fujita Y, Wagner DR, Biviji AA, Duncan NA, Lotz JC
• A special theory of biphasic mixtures and experimental results for human annulus fibrosus tested in confined compression.
  Journal of biomechanical engineering 2000 Klisch SM, Lotz JC
• Tibial plateau fracture as a measure of early estrogen-dependent bone fragility in rats.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000 Lotz JC, Kroeber MW, Heilmann M, Pericherla K, Kimmel D, Kinney JH, Lane NE
• Application of a fiber-reinforced continuum theory to multiple deformations of the annulus fibrosus.
  Journal of biomechanics 1999 Klisch SM, Lotz JC
• Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass.
  Development (Cambridge, England) 1999 Filvaroff E, Erlebacher A, Ye J, Gitelman SE, Lotz J, Heillman M, Derynck R
• Randomized biomechanical study of zone II human flexor tendon repairs.
  The Journal of hand surgery 1999 Diao E, Soejima O, Lotz J, Hariharan J
• Comparison of bone-patellar tendon-bone interference screw fixation and hamstring transfemoral screw fixation in anterior cruciate ligament reconstruction.
  Orthopedics 1999 Randall RL, Wolf EM, Heilmann MR, Lotz J
• The biomechanics of prevention and treatment for low back pain: 2nd international workshop.
  Clinical biomechanics (Bristol, Avon) 1999 Lotz JC
• Collagen type I metabolism after bone surgery.
  Archives of orthopaedic and trauma surgery 1999 Lotz J, Gaertner T, Hahn M, Prellwitz W
• Compression-induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element study.
  Spine 1998 Lotz JC, Colliou OK, Chin JR, Duncan NA, Liebenberg E
• Use of a collagen-hydroxyapatite matrix in spinal fusion. A rabbit model.
  Spine 1998 Tay BK, Le AX, Heilman M, Lotz J, Bradford DS
• Hepatocellular hyperplasia, plasmacytoma formation, and extramedullary hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice.
  The American journal of pathology 1998 Schirmacher P, Peters M, Ciliberto G, Blessing M, Lotz J, Meyer zum Büschenfelde KH, Rose-John S
• Analytic model to predict the strength of tendon repairs.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1998 Lotz JC, Hariharan JS, Diao E
• [Follow-up of collagen and bone metabolism in patients with cement-free total hip endoprosthesis].
  Zeitschrift fur Orthopadie und ihre Grenzgebiete 1998 Meurer A, Lotz J, Giesa M, Eckardt A, Prellwitz W, Heine J
• Use of ultrasound in spinal arthrodesis. A rabbit model.
  Spine 1998 Glazer PA, Heilmann MR, Lotz JC, Bradford DS
• Effect of long-term treatment with GH on bone metabolism, bone mineral density and bone elasticity in GH-deficient adults.
  Clinical endocrinology 1998 Kann P, Piepkorn B, Schehler B, Andreas J, Lotz J, Prellwitz W, Beyer J
• Effect of the pedicle and posterior arch on vertebral body strength predictions in finite element modeling.
  Spine 1998 Whyne CM, Hu SS, Klisch S, Lotz JC
• Frozen storage affects the compressive creep behavior of the porcine intervertebral disc.
  Spine 1997 Bass EC, Duncan NA, Hariharan JS, Dusick J, Bueff HU, Lotz JC
• Carbonated apatite cement augmentation of pedicle screw fixation in the lumbar spine.
  Spine 1997 Lotz JC, Hu SS, Chiu DF, Yu M, Colliou O, Poser RD
• Partial lacerations of human digital flexor tendons: a biomechanical analysis.
  The Journal of hand surgery 1997 Hariharan JS, Diao E, Soejima O, Lotz JC
• Radial tensile properties of the lumbar annulus fibrosus are site and degeneration dependent.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1997 Fujita Y, Duncan NA, Lotz JC
• Use of electromagnetic fields in a spinal fusion. A rabbit model.
  Spine 1997 Glazer PA, Heilmann MR, Lotz JC, Bradford DS
• Biomechanical analysis of multilevel fixation methods in the lumbar spine.
  Spine 1997 Glazer PA, Colliou O, Klisch SM, Bradfore DS, Bueff HU, Lotz JC
• Biomechanical analysis of lumbosacral fixation.
  Spine 1996 Glazer PA, Colliou O, Lotz JC, Bradford DS
• Effect of peripheral suture depth on strength of tendon repairs.
  The Journal of hand surgery 1996 Diao E, Hariharan JS, Soejima O, Lotz JC
• Magnetic resonance imaging of trabecular bone structure in the distal radius: relationship with X-ray tomographic microscopy and biomechanics.
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 1996 Majumdar S, Newitt D, Mathur A, Osman D, Gies A, Chiu E, Lotz J, Kinney J, Genant H
• Comparative mechanical analysis of dorsal versus palmar placement of core suture for flexor tendon repairs.
  The Journal of hand surgery 1995 Soejima O, Diao E, Lotz JC, Hariharan JS
• Instrumentation of the cervicothoracic junction after destabilization.
  Spine 1995 Bueff HU, Lotz JC, Colliou OK, Khapchik V, Ashford F, Hu SS, Bozic K, Bradford DS
• Evaluation of an automated chromogenic substrate assay for the rapid determination of hirudin in plasma.
  Thrombosis research 1995 Hafner G, Fickenscher K, Friesen HJ, Rupprecht HJ, Konheiser U, Ehrenthal W, Lotz J, Prellwitz W
• Stress distributions within the proximal femur during gait and falls: implications for osteoporotic fracture.
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 1995 Lotz JC, Cheal EJ, Hayes WC
• Gender differences in bone density, skeletal geometry, and fracture biomechanics.
  Radiology 1994 Genant HK, Glüer CC, Lotz JC
• Fracture prediction for the proximal femur using finite element models: Part I--Linear analysis.
  Journal of biomechanical engineering 1991 Lotz JC, Cheal EJ, Hayes WC
• Fracture prediction for the proximal femur using finite element models: Part II--Nonlinear analysis.
  Journal of biomechanical engineering 1991 Lotz JC, Cheal EJ, Hayes WC
• Mechanical properties of metaphyseal bone in the proximal femur.
  Journal of biomechanics 1991 Lotz JC, Gerhart TN, Hayes WC
• The use of quantitative computed tomography to estimate risk of fracture of the hip from falls.
  The Journal of bone and joint surgery. American volume 1990 Lotz JC, Hayes WC
• Biomechanical properties of the proximal femur determined in vitro by single-energy quantitative computed tomography.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1989 Esses SI, Lotz JC, Hayes WC