Jeffrey Gotts, MD, PhD
Assistant Professor
Medicine
School of Medicine

My focus is to improve the care of critically ill patients through my roles as a practicing intensivist, co-director of the medical ICU, and teacher and mentor of resident and fellow clinical trainees. I also conduct basic science investigations of bacterial and viral pneumonia, focusing on mechanisms of injury and recovery.

Education & Training

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• Residency School of Medicine - Internal Medicine University of California, San Francisco

Grants and Projects

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• Mechanisms of Mesenchymal Stem Cell Therapy in Viral-Induced Acute Lung Injury, NIH, 2014
• Mechanisms of Svz Expansion Following Cortical Injury, NIH, 2000-1900

Publications (42)

Top publication keywords:
Orthomyxoviridae InfectionsAngiopoietin-2Streptococcus pneumoniaeVitamin ELungReceptors, LipoxinAcute Lung InjuryElectronic Nicotine Delivery SystemsTobacco Smoke PollutionMesenchymal Stem Cell TransplantationAerosolsOrthomyxoviridaeLung InjuryLipoxinsPneumonia, Pneumococcal

• Biological Effects of Corticosteroids on Pneumococcal Pneumonia in Mice and Humans.
  Research square 2024 Taenaka H, Wick KD, Sarma A, Matsumoto S, Ghale R, Fang X, Maishan M, Gotts JE, Langelier CR, Calfee CS, Matthay MA
• A New Global Definition of Acute Respiratory Distress Syndrome.
  American journal of respiratory and critical care medicine 2024 Matthay MA, Arabi Y, Arroliga AC, Bernard G, Bersten AD, Brochard LJ, Calfee CS, Combes A, Daniel BM, Ferguson ND, Gong MN, Gotts JE, Herridge MS, Laffey JG, Liu KD, Machado FR, Martin TR, McAuley DF,…
• Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection.
  Frontiers in immunology 2023 Maishan M, Sarma A, Chun LF, Caldera S, Fang X, Abbott J, Christenson SA, Langelier CR, Calfee CS, Gotts JE, Matthay MA
• Impact of e-cigarette aerosol on primary human alveolar epithelial type 2 cells.
  American journal of physiology. Lung cellular and molecular physiology 2022 Wick KD, Fang X, Maishan M, Matsumoto S, Spottiswoode N, Sarma A, Simoneau C, Khakoo M, Langelier C, Calfee CS, Gotts JE, Matthay MA
• Cigarette Smoke Exposure and Acute Respiratory Distress Syndrome in Sepsis: Epidemiology, Clinical Features, and Biologic Markers.
  American journal of respiratory and critical care medicine 2022 Moazed F, Hendrickson C, Jauregui A, Gotts J, Conroy A, Delucchi K, Zhuo H, Arambulo M, Vessel K, Ke S, Deiss T, Ni A, Leligdowicz A, Abbott J, Cohen MJ, Sinha P, Gomez A, Kangelaris K, Kornblith L, …

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• Aerosolized vitamin E acetate causes oxidative injury in mice and in alveolar macrophages.
  American journal of physiology. Lung cellular and molecular physiology 2022 Matsumoto S, Traber MG, Leonard SW, Choi J, Fang X, Maishan M, Wick KD, Jones KD, Calfee CS, Gotts JE, Matthay MA
• Delayed angiopoietin-2 blockade reduces influenza-induced lung injury and improves survival in mice.
  Physiological reports 2021 Gotts JE, Maishan M, Chun L, Fang X, Han CY, Chiueh V, Khakoo AY, Lee T, Stolina M, Matthay MA
• Euglycemic diabetic ketoacidosis following major vascular surgery is a new item on the differential for postoperative acidosis.
  Journal of vascular surgery cases and innovative techniques 2021 Gomez-Sanchez CM, Wu BX, Gotts JE, Chang RW
• Inhibition of the lipoxin A4 and resolvin D1 receptor impairs host response to acute lung injury caused by pneumococcal pneumonia in mice.
  American journal of physiology. Lung cellular and molecular physiology 2021 Siegel ER, Croze RH, Fang X, Matthay MA, Gotts JE
• Dose-Dependent Pulmonary Toxicity of Aerosolized Vitamin E Acetate.
  American journal of respiratory cell and molecular biology 2020 Matsumoto S, Fang X, Traber MG, Jones KD, Langelier C, Hayakawa Serpa P, Calfee CS, Matthay MA, Gotts JE
• The ex vivo perfused human lung is resistant to injury by high-dose S. pneumoniae bacteremia.
  American journal of physiology. Lung cellular and molecular physiology 2020 Ross JT, Nesseler N, Leligdowicz A, Zemans RL, Mahida RY, Minus E, Langelier C, Gotts JE, Matthay MA
• Treatment for severe acute respiratory distress syndrome from COVID-19.
  The Lancet. Respiratory medicine 2020 Matthay MA, Aldrich JM, Gotts JE
• What are the respiratory effects of e-cigarettes?
  BMJ (Clinical research ed.) 2019 Gotts JE, Jordt SE, McConnell R, Tarran R
• Clinically relevant model of pneumococcal pneumonia, ARDS, and nonpulmonary organ dysfunction in mice.
  American journal of physiology. Lung cellular and molecular physiology 2019 Gotts JE, Bernard O, Chun L, Croze RH, Ross JT, Nesseler N, Wu X, Abbott J, Fang X, Calfee CS, Matthay MA
• Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply.
  The Lancet. Respiratory medicine 2019 Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS
• High-power vaping injures the human lung.
  American journal of physiology. Lung cellular and molecular physiology 2019 Gotts JE
• Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial.
  The Lancet. Respiratory medicine 2018 Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, …
• Assessment of industry data on pulmonary and immunosuppressive effects of IQOS.
  Tobacco control 2018 Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J
• Possible hepatotoxicity of IQOS.
  Tobacco control 2018 Chun L, Moazed F, Matthay M, Calfee C, Gotts J
• Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.
  American journal of physiology. Lung cellular and molecular physiology 2018 Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA
• Cell-based Therapy in Sepsis. A Step Closer.
  American journal of respiratory and critical care medicine 2018 Gotts JE, Matthay MA
• Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties".
  American journal of physiology. Lung cellular and molecular physiology 2017 Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE
• Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice.
  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2017 Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA
• Local lung hypoxia determines epithelial fate decisions during alveolar regeneration.
  Nature cell biology 2017 Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE
• Pulmonary toxicity of e-cigarettes.
  American journal of physiology. Lung cellular and molecular physiology 2017 Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE
• Cathepsin L Helps to Defend Mice from Infection with Influenza A.
  PloS one 2016 Xu X, Greenland JR, Gotts JE, Matthay MA, Caughey GH
• Persistent Pathology in Influenza-Infected Mouse Lungs.
  American journal of respiratory cell and molecular biology 2016 Kanegai CM, Xi Y, Donne ML, Gotts JE, Driver IH, Amidzic G, Lechner AJ, Jones KD, Vaughan AE, Chapman HA, Rock JR
• Sepsis: pathophysiology and clinical management.
  BMJ (Clinical research ed.) 2016 Gotts JE, Matthay MA
• Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury.
  Nature 2014 Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA
• Endogenous and exogenous cell-based pathways for recovery from acute respiratory distress syndrome.
  Clinics in chest medicine 2014 Gotts JE, Matthay MA
• Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy.
  American journal of physiology. Lung cellular and molecular physiology 2014 Gotts JE, Abbott J, Matthay MA
• Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome.
  Annals of intensive care 2014 Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, …
• Treating ARDS: new hope for a tough problem.
  The Lancet. Respiratory medicine 2013 Gotts JE, Matthay MA
• Cell therapy for lung disease: a step forward.
  Chest 2013 Gotts JE, Matthay MA
• Mesenchymal stem cells and the stem cell niche: a new chapter.
  American journal of physiology. Lung cellular and molecular physiology 2012 Gotts JE, Matthay MA
• Mesenchymal stem cells and acute lung injury.
  Critical care clinics 2011 Gotts JE, Matthay MA
• Mechanisms of subventricular zone expansion after focal cortical ischemic injury.
  The Journal of comparative neurology 2005 Gotts JE, Chesselet MF
• Vascular changes in the subventricular zone after distal cortical lesions.
  Experimental neurology 2005 Gotts JE, Chesselet MF
• Migration and fate of newly born cells after focal cortical ischemia in adult rats.
  Journal of neuroscience research 2005 Gotts JE, Chesselet MF
• Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus.
  Molecular therapy : the journal of the American Society of Gene Therapy 2002 Liang Q, Gotts J, Satyamurthy N, Barrio J, Phelps ME, Gambhir SS, Herschman HR
• Focal brain injury, FGF-2 and the adverse effects of excessive motor demand on cortical and nigral degeneration: marked protection by delayed intermittent exposure to halothane.
  Journal of neurotrauma 2000 Gotts JE, Press C, Leasure JL, Schallert T
• Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Kawamata T, Dietrich WD, Schallert T, Gotts JE, Cocke RR, Benowitz LI, Finklestein SP