Jeffrey Fineman, MD
Professor
Pediatrics
School of Medicine

Education & Training

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• Diversity, Equity, Inclusion Champion Training UCSF 2021
• Pediatric Critical Care Fellowship UCSF 06/1990
• Pediatric Chief Resident NYU/Bellevue 06/1988
• Pediatric Residency NYU/Bellevue 06/1987
• MD Medicine New York University School of Medicine 06/1984

Websites

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• Clinical Profile at UCSF Benioff Children's Hospital (ucsfbenioffchildrens.org)

Grants and Projects

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• Metabolic Reprogramming and Pulmonary Vascular Disease in Congenital Heart Disease, NIH/NHLBI (University of Arizona), 2020-2025
• OMX-CV, A Novel Oxygen Delivery Biotherapeutic for Treatment of Hemorrhagic Shock in the Battlefield, Dept. of the Army - USAMRAA, 2020-2023
• TOMORROW: pediaTric use Of Macitentan tO delay disease pRogRessiOn in PAH Worldwide, Actelion Pharmaceuticals Ltd, 2018-2023
• Large Mammal Neuroprotective Clinical Platform, Bill and Melinda Gates Foundation, 2018-2022
• Research Training in Pediatric Critical Care Medicine, NIH, 2005-2022
• PPHNet BiOspecimen Laboratory Depot (PPHNet-BOLD), Cardiovascular Medical Research and Education Fund (Vanderbilt University Medical Center), 2017-2021
• Development of an oxygen delivery biotherapeutic for the preservation of myocardial function during pediatric cardiopulmonary bypass, NIH, 2017-2021
• Perinatal NO signaling in congenital heart disease, NIH, 2017-2021
• Perinatal Pulmonary Hypertension: Developmental Mediators, NIH, 1999-2018
• Pediatric Clinical Research Center, NIH, 1981-2007

Publications (229)

Top publication keywords:
Pulmonary CirculationLungVascular ResistanceNitric Oxide Synthase Type IIISheepVasodilator AgentsNitric Oxide SynthaseHeart Defects, CongenitalEndothelin-1Nitric OxidePulmonary ArteryHypertension, PulmonaryVasodilationPersistent Fetal Circulation SyndromeNatriuretic Peptide, Brain

• VIEWING PULMONARY HYPERTENSION THROUGH A PEDIATRIC LENS.
  The European respiratory journal 2024 Agarwal S, Fineman J, Cornfield DN, Alvira CM, Zamanian RT, Goss K, Yuan K, Bonnet S, Boucherat O, Pullamsetti S, Alcázar MA, Goncharova E, Kudryashova TV, Nicolls MR, de Jesús Pérez V
• Actigraphy methodology in the Kids Mod PAH trial: Physical activity as a functional endpoint in pediatric clinical trials.
  Pulmonary circulation 2024 Avitabile CM, Krishnan US, Yung D, Handler SS, Varghese N, Bates A, Fineman J, Sullivan R, Friere G, Austin E, Mullen MP, Pereira C, Christensen EJ, Yenokyan G, Collaco JM, Abman SH, Romer L, Dunbar …
• Mitochondrial network dynamics in pulmonary disease: Bridging the gap between inflammation, oxidative stress, and bioenergetics.
  Redox biology 2024 Pokharel MD, Garcia-Flores A, Marciano D, Franco MC, Fineman JR, Aggarwal S, Wang T, Black SM
• Novel Relationship between Mitofusin 2-Mediated Mitochondrial Hyperfusion, Metabolic Remodeling, and Glycolysis in Pulmonary Arterial Endothelial Cells.
  International journal of molecular sciences 2023 Yegambaram M, Sun X, Flores AG, Lu Q, Soto J, Richards J, Aggarwal S, Wang T, Gu H, Fineman JR, Black SM
• Simvastatin restores pulmonary endothelial function in the setting of pulmonary over-circulation.
  Nitric oxide : biology and chemistry 2023 Boehme JT, Sun X, Lu Q, Barton J, Wu X, Gong W, Raff GW, Datar SA, Wang T, Fineman JR, Black SM

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• Mitochondrial hyperfusion induces metabolic remodeling in lung endothelial cells by modifying the activities of electron transport chain complexes I and III.
  Free radical biology & medicine 2023 Yegambaram M, Sun X, Lu Q, Jin Y, Ornatowski W, Soto J, Aggarwal S, Wang T, Tieu K, Gu H, Fineman JR, Black SM
• Prostaglandin-E1 infusion in persistent pulmonary hypertension of the newborn.
  Pediatric pulmonology 2023 Tsoi SM, Nawaytou H, Almeneisi H, Steurer M, Zhao Y, Fineman JR, Keller RL
• Kids Mod PAH trial: A multicenter trial comparing mono- versus duo-therapy for initial treatment of pediatric pulmonary hypertension.
  Pulmonary circulation 2023 Collaco JM, Abman SH, Austin ED, Avitabile CM, Bates A, Fineman JR, Freire GA, Handler SS, Ivy DD, Krishnan US, Mullen MP, Varghese NP, Yung D, Nies MK, Everett AD, Zimmerman KO, Simmons W, …
• Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy.
  Children (Basel, Switzerland) 2023 Mike JK, White Y, Hutchings RS, Vento C, Ha J, Iranmahboub A, Manzoor H, Gunewardena A, Cheah C, Wang A, Goudy BD, Lakshminrusimha S, Long-Boyle J, Fineman JR, Ferriero DM, Maltepe E
• Perinatal Azithromycin Provides Limited Neuroprotection in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy.
  Stroke 2023 Mike JK, White Y, Hutchings RS, Vento C, Ha J, Manzoor H, Lee D, Losser C, Arellano K, Vanhatalo O, Seifert E, Gunewardena A, Wen B, Wang L, Wang A, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, …
• Safety and tolerability of continuous inhaled iloprost in critically ill pediatric pulmonary hypertension patients: A retrospective case series.
  Pulmonary circulation 2023 Colglazier E, Ng AJ, Parker C, Woolsey D, Holmes R, Dsouza A, Becerra J, Stevens L, Nawaytou H, Keller RL, Fineman JR
• Endothelin-1 acutely increases nitric oxide production via the calcineurin mediated dephosphorylation of Caveolin-1.
  Nitric oxide : biology and chemistry 2023 Yegambaram M, Kumar S, Wu X, Lu Q, Sun X, Garcia Flores A, Meadows ML, Barman S, Fulton D, Wang T, Fineman JR, Black SM
• Associated radiation exposure from medical imaging and excess lifetime risk of developing cancer in pediatric patients with pulmonary hypertension.
  Pulmonary circulation 2023 Mahendra M, Chu P, Amin EK, Nawaytou H, Duncan JR, Fineman JR, Smith-Bindman R
• Measurement of Physical Activity by Actigraphy in Infants and Young Children with Pulmonary Arterial Hypertension.
  The Journal of pediatrics 2023 Avitabile CM, Yung D, Handler S, Hopper RK, Fineman J, Freire G, Varghese N, Mullen MP, Krishnan US, Austin E, Silveira L, Ivy DD
• Metabolic reprogramming, oxidative stress, and pulmonary hypertension.
  Redox biology 2023 Pokharel MD, Marciano DP, Fu P, Franco MC, Unwalla H, Tieu K, Fineman JR, Wang T, Black SM
• Respiratory mechanics and gas exchange in an ovine model of congenital heart disease with increased pulmonary blood flow and pressure.
  Frontiers in physiology 2023 Soares JHN, Raff GW, Fineman JR, Datar SA
• Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension.
  The European respiratory journal 2023 Chakraborty A, Nathan A, Orcholski M, Agarwal S, Shamskhou EA, Auer N, Mitra A, Guardado ES, Swaminathan G, Condon DF, Yu J, McCarra M, Juul NH, Mallory A, Guzman-Hernandez RA, Yuan K, Rojas V, …
• Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission.
  The Journal of biological chemistry 2023 Lu Q, Sun X, Yegambaram M, Ornatowski W, Wu X, Wang H, Garcia-Flores A, Da Silva V, Zemskov EA, Tang H, Fineman JR, Tieu K, Wang T, Black SM
• Hemodynamic assessment of transitioning from parenteral prostacyclin to selexipag in pediatric pulmonary hypertension.
  Pulmonary circulation 2022 Colglazier E, Stevens L, Parker C, Nawaytou HM, Amin EK, Becerra J, Steurer M, Fineman JR
• Predictability and stability testing to assess clinical decision instrument performance for children after blunt torso trauma.
  PLOS digital health 2022 Kornblith AE, Singh C, Devlin G, Addo N, Streck CJ, Holmes JF, Kuppermann N, Grupp-Phelan J, Fineman J, Butte AJ, Yu B
• Caveolin-1 associated with severe (pediatric-onset) presentation of pulmonary arterial hypertension.
  Pulmonary circulation 2022 Farrell R, Colglazier E, Parker C, Stevens L, Austin ED, Fineman JR
• Persistence of persistent pulmonary hypertension of the newborn: A case of de novo TBX4 variant.
  Pulmonary circulation 2022 Tsoi SM, Jones K, Colglazier E, Parker C, Nawaytou H, Teitel D, Fineman JR, Keller RL
• Cardiac Catheterization and Hemodynamics in a Multicenter Cohort of Children with Pulmonary Hypertension.
  Annals of the American Thoracic Society 2022 Rosenzweig EB, Bates A, Mullen MP, Abman SH, Austin ED, Everett A, Fineman J, Feinstein J, Hopper RK, Kinsella JP, Krishnan US, Lu M, Mandl KD, Raj JU, Varghese N, Yung D, Handler SS, Sleeper LA
• Progress in Pulmonary Vein Stenosis: Lessons from Success in Treating Pulmonary Arterial Hypertension.
  Children (Basel, Switzerland) 2022 Jenkins KJ, Fineman JR
• Defining Longer-Term Outcomes in an Ovine Model of Moderate Perinatal Hypoxia-Ischemia.
  Developmental neuroscience 2022 Mike JK, Wu KY, White Y, Pathipati P, Ndjamen B, Hutchings RS, Losser C, Vento C, Arellano K, Vanhatalo O, Ostrin S, Windsor C, Ha J, Alhassen Z, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long…
• Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.
  The Journal of clinical investigation 2022 Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, …
• Building a dedicated pediatric pulmonary hypertension program: A consensus statement from the pediatric pulmonary hypertension network.
  Pulmonary circulation 2022 Handler SS, Varghese NP, Rosenzweig EB, Yung D, Krishnan U, Whalen E, Bates A, Avitabile CM, Jackson EO, Hirsch R, Fineman J, Abman SH, Pediatric Pulmonary Hypertension Network (PPHNet)
• Genetics dictating therapeutic decisions in pediatric pulmonary hypertension? A case report suggesting we are getting closer.
  Pulmonary circulation 2022 Stevens L, Colglazier E, Parker C, Amin EK, Nawaytou H, Teitel D, Reddy VM, Welch CL, Chung WK, Fineman JR
• Characterisation of paediatric pulmonary hypertensive vascular disease from the PPHNet Registry.
  The European respiratory journal 2021 Abman SH, Mullen MP, Sleeper LA, Austin ED, Rosenzweig EB, Kinsella JP, Ivy D, Hopper RK, Raj JU, Fineman J, Keller RL, Bates A, Krishnan US, Avitabile CM, Davidson A, Natter MD, Mandl KD, Pediatric …
• Advanced Microparticulate/Nanoparticulate Respirable Dry Powders of a Selective RhoA/Rho Kinase (Rock) Inhibitor for Targeted Pulmonary Inhalation Aerosol Delivery.
  Pharmaceutics 2021 Muralidharan P, Hayes D, Fineman JR, Black SM, Mansour HM
• Insights into the impact of sections and departments on your career: The APS-SPR Virtual Chat Series.
  Pediatric research 2021 Davis SD, Fineman JR, St Geme Iii JW
• Biallelic variants of <i>ATP13A3</i> cause dose-dependent childhood-onset pulmonary arterial hypertension characterised by extreme morbidity and mortality.
  Journal of medical genetics 2021 Machado RD, Welch CL, Haimel M, Bleda M, Colglazier E, Coulson JD, Debeljak M, Ekstein J, Fineman JR, Golden WC, Griffin EL, Hadinnapola C, Harris MA, Hirsch Y, Hoover-Fong JE, Nogee L, Romer LH, …
• Mortality from Pulmonary Hypertension in the Pediatric Cardiac ICU.
  American journal of respiratory and critical care medicine 2021 Morell E, Gaies M, Fineman JR, Charpie J, Rao R, Sasaki J, Zhang W, Reichle G, Banerjee M, Tabbutt S
• Safety and Tolerability of a Rapid Transition From Intravenous Treprostinil to Oral Selexipag in Three Adolescent Patients With Pulmonary Arterial Hypertension.
  The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 2021 Colglazier E, Ng AJ, Parker C, Nawaytou H, Fineman JR
• Monitoring deep-tissue oxygenation with a millimeter-scale ultrasonic implant.
  Nature biotechnology 2021 Sonmezoglu S, Fineman JR, Maltepe E, Maharbiz MM
• Pulmonary Arteriovenous Malformations and the Hepatic "Black Box": Are We Emerging From the Darkness?
  JACC. Basic to translational science 2021 Rajagopal SK, Fineman JR
• Practice patterns of pulmonary hypertension secondary to left heart disease among pediatric pulmonary hypertension providers.
  Pulmonary circulation 2021 Nawaytou H, Fineman JR, Moledina S, Ivy D, Abman SH, Cerro MJD
• Comparison of l-Carnitine and l-Carnitine HCL salt for targeted lung treatment of pulmonary hypertension (PH) as inhalation aerosols: Design, comprehensive characterization, in vitro 2D/3D cell cultures, and in vivo MCT-Rat model of PH.
  Pulmonary pharmacology & therapeutics 2021 Acosta MF, Muralidhran P, Abrahamson MD, Grijalva CL, Carver M, Tang H, Klinger C, Fineman JR, Black SM, Mansour HM
• HIF-1α promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow.
  Scientific reports 2021 Boehme JT, Morris CJ, Chiacchia SR, Gong W, Wu KY, Kameny RJ, Raff GW, Fineman JR, Maltepe E, Datar SA
• Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension: design, characterization, aerosolization, in vitro 2D/3D human lung cell cultures, and in vivo efficacy.
  Therapeutic advances in respiratory disease 2021 Acosta MF, Muralidharan P, Grijalva CL, Abrahamson MD, Hayes D, Fineman JR, Black SM, Mansour HM
• Arginine recycling in endothelial cells is regulated BY HSP90 and the ubiquitin proteasome system.
  Nitric oxide : biology and chemistry 2020 Wu X, Sun X, Sharma S, Lu Q, Yegambaram M, Hou Y, Wang T, Fineman JR, Black SM
• Novel Documentation of Onset and Rapid Advancement of Pulmonary Arterial Hypertension without Symptoms in BMPR2 Mutation Carriers: Cautionary Tales?
  American journal of respiratory and critical care medicine 2020 Amin EK, Austin ED, Parker C, Colglazier E, Nawaytou H, Leary PJ, Hemnes AR, Teitel D, Fineman JR
• Inhalable Nanoparticles/Microparticles of an AMPK and Nrf2 Activator for Targeted Pulmonary Drug Delivery as Dry Powder Inhalers.
  The AAPS journal 2020 Acosta MF, Abrahamson MD, Encinas-Basurto D, Fineman JR, Black SM, Mansour HM
• Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics.
  Redox biology 2020 Lu Q, Zemskov EA, Sun X, Wang H, Yegambaram M, Wu X, Garcia-Flores A, Song S, Tang H, Kangath A, Cabanillas GZ, Yuan JX, Wang T, Fineman JR, Black SM
• Complex interplay between autophagy and oxidative stress in the development of pulmonary disease.
  Redox biology 2020 Ornatowski W, Lu Q, Yegambaram M, Garcia AE, Zemskov EA, Maltepe E, Fineman JR, Wang T, Black SM
• Pharmacokinetics of Oral Treprostinil in Children With Pulmonary Arterial Hypertension.
  Journal of cardiovascular pharmacology 2020 Hopper RK, Ivy DD, Yung D, Mullen MP, Hanna BD, Kirkpatrick E, Hirsch R, Austin ED, Fineman J, Solum D, Deng CQ, Feinstein JA
• The many faces and outcomes of pulmonary vein stenosis in early childhood.
  Pediatric pulmonology 2020 Humpl T, Fineman J, Qureshi AM
• Equipoise and Acumen in Pediatric Acute Respiratory Distress Syndrome Research.
  American journal of respiratory and critical care medicine 2020 Oishi P, Fineman JR
• TGF-β1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis.
  Redox biology 2020 Sun X, Lu Q, Yegambaram M, Kumar S, Qu N, Srivastava A, Wang T, Fineman JR, Black SM
• Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease.
  Pulmonary circulation 2020 Zhu T, Chiacchia S, Kameny RJ, Garcia De Herreros A, Gong W, Raff GW, Boehme JB, Maltepe E, Lasheras JC, Black SM, Datar SA, Fineman JR
• Extracorporeal Membrane Oxygenation in Pediatric Pulmonary Hypertension.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2020 Morell E, Rajagopal SK, Oishi P, Thiagarajan RR, Fineman JR, Steurer MA
• Clinical Utility of Echocardiography in Former Preterm Infants with Bronchopulmonary Dysplasia.
  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2020 Nawaytou H, Steurer MA, Zhao Y, Guslits E, Teitel D, Fineman JR, Keller RL
• Outcomes of pulmonary vascular disease in infants conceived with non-IVF fertility treatment and assisted reproductive technologies at 1 year of age.
  Pediatric pulmonology 2019 Fineman DC, Baer RJ, Chambers CD, Rajagopal S, Maltepe E, Rinaudo PF, Fineman JR, Jelliffe-Pawlowski LL, Steurer MA
• Oral treprostinil in transition or as add-on therapy in pediatric pulmonary arterial hypertension.
  Pulmonary circulation 2019 Ivy DD, Feinstein JA, Yung D, Mullen MP, Kirkpatrick EC, Hirsch R, Austin ED, Fineman J, Truong U, Solum D, Deng CQ, Hopper RK
• EXPRESS: Acute Vasoreactivity Testing in Pediatric Idiopathic Pulmonary Arterial Hypertension: an international Survey on Current Practice.
  Pulmonary circulation 2019 Caicedo L, Hopper RK, Garcia H, Ivy DD, Haag D, Fineman J, Humpi T, Al-Tamimi O, Feinstein J, Berger RM, Berman-Rosenzweig E, Kashour T, Diaz GF, Mendoza A, Bobhate P, Handler S, Lopes AA, Barwad P, …
• Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling.
  American journal of respiratory cell and molecular biology 2019 Johnson Kameny R, Datar SA, Boehme JB, Morris C, Zhu T, Goudy BD, Johnson EG, Galambos C, Raff GW, Sun X, Wang T, Chiacchia SR, Lu Q, Black SM, Maltepe E, Fineman JR
• Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury.
  Frontiers in physiology 2019 Kelly GT, Faraj R, Zhang Y, Maltepe E, Fineman JR, Black SM, Wang T
• Mortality in infants with bronchopulmonary dysplasia: Data from cardiac catheterization.
  Pediatric pulmonology 2019 Steurer MA, Nawaytou H, Guslits E, Colglazier E, Teitel D, Fineman JR, Keller RL
• Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease.
  Antioxidants & redox signaling 2019 Zemskov EA, Lu Q, Ornatowski W, Klinger CN, Desai AA, Maltepe E, Yuan JX, Wang T, Fineman JR, Black SM
• Correction: Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.
  PLoS biology 2019 Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, …
• Two patients with FOXF1 mutations with alveolar capillary dysplasia with misalignment of pulmonary veins and other malformations: Two different presentations and outcomes.
  American journal of medical genetics. Part A 2018 Abu-El-Haija A, Fineman J, Connolly AJ, Murali P, Judge LM, Slavotinek AM
• Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.
  PLoS biology 2018 Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, …
• Intensive Care Mortality Prognostic Model for Pediatric Pulmonary Hypertension.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2018 Balkin EM, Zinter MS, Rajagopal SK, Keller RL, Fineman JR, Steurer MA
• Enhancing the Development and Retention of Physician-Scientists in Academic Pediatrics: Strategies for Success.
  The Journal of pediatrics 2018 Alvira CM, Steinhorn RH, Balistreri WF, Fineman JR, Oishi PE, Padbury JF, Kinsella JP, Abman SH
• Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease.
  American journal of physiology. Heart and circulatory physiology 2018 Kameny RJ, He Y, Zhu T, Gong W, Raff GW, Chapin CJ, Datar SA, Boehme JT, Hata A, Fineman JR
• KLF2-mediated disruption of PPAR-γ signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.
  American journal of physiology. Heart and circulatory physiology 2018 Morris CJ, Kameny RJ, Boehme J, Gong W, He Y, Zhu T, Maltepe E, Raff GW, Fineman JR, Datar SA
• The Left Ventricle in Congenital Diaphragmatic Hernia: Implications for the Management of Pulmonary Hypertension.
  The Journal of pediatrics 2018 Kinsella JP, Steinhorn RH, Mullen MP, Hopper RK, Keller RL, Ivy DD, Austin ED, Krishnan US, Rosenzweig EB, Fineman JR, Everett AD, Hanna BD, Humpl T, Raj JU, Abman SH, Pediatric Pulmonary Hypertension…
• Safety, efficacy and Management of subcutaneous treprostinil infusions in the treatment of severe pediatric pulmonary hypertension.
  International journal of cardiology 2018 Levy M, Del Cerro MJ, Nadaud S, Vadlamudi K, Colgazier E, Fineman J, Bonnet D, Adatia I
• Multicenter mortality and morbidity associated with pulmonary hypertension in the pediatric intensive care unit.
  Pulmonary circulation 2017 Balkin EM, Steurer MA, Delagnes EA, Zinter MS, Rajagopal S, Keller RL, Fineman JR
• Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2017 Black SM, Field-Ridley A, Sharma S, Kumar S, Keller RL, Kameny R, Maltepe E, Datar SA, Fineman JR
• Pulmonary veno-occlusive disease in a pediatric hematopoietic stem cell transplant patient: a cautionary tale.
  Leukemia & lymphoma 2017 Zinter MS, Melton A, Sabnis AJ, Dvorak CC, Elicker BM, Nawaytou HM, Kameny RJ, Fineman JR
• Pushing the envelope: a treat and repair strategy for patients with advanced pulmonary hypertension associated with congenital heart disease.
  Pulmonary circulation 2017 Kameny RJ, Colglazier E, Nawaytou H, Moore P, Reddy VM, Teitel D, Fineman JR
• Evaluation and Management of Pulmonary Hypertension in Children with Bronchopulmonary Dysplasia.
  The Journal of pediatrics 2017 Krishnan U, Feinstein JA, Adatia I, Austin ED, Mullen MP, Hopper RK, Hanna B, Romer L, Keller RL, Fineman J, Steinhorn R, Kinsella JP, Ivy DD, Rosenzweig EB, Raj U, Humpl T, Abman SH, Pediatric …
• Pulmonary vein stenosis of ex-premature infants with pulmonary hypertension and bronchopulmonary dysplasia, epidemiology, and survival from a multicenter cohort.
  Pediatric pulmonology 2017 Mahgoub L, Kaddoura T, Kameny AR, Lopez Ortego P, Vanderlaan RD, Kakadekar A, Dicke F, Rebeyka I, Calderone CA, Redington A, Del Cerro MJ, Fineman J, Adatia I
• The Prescient Prognosticator? Hepatoma-derived Growth Factor in Pulmonary Hypertension.
  American journal of respiratory and critical care medicine 2016 Kameny RJ, Fineman JR
• Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation.
  American journal of physiology. Heart and circulatory physiology 2016 Boehme J, Sun X, Tormos KV, Gong W, Kellner M, Datar SA, Kameny RJ, Yuan JX, Raff GW, Fineman JR, Black SM, Maltepe E
• Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn: Results of the Randomized Multicenter Placebo-Controlled Exploratory Trial.
  The Journal of pediatrics 2016 Steinhorn RH, Fineman J, Kusic-Pajic A, Cornelisse P, Gehin M, Nowbakht P, Pierce CM, Beghetti M, FUTURE-4 study investigators
• Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells.
  American journal of respiratory cell and molecular biology 2016 Sun X, Kellner M, Desai AA, Wang T, Lu Q, Kangath A, Qu N, Klinger C, Fratz S, Yuan JX, Jacobson JR, Garcia JG, Rafikov R, Fineman JR, Black SM
• Pulmonary Hypertension.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2016 Oishi P, Fineman JR
• Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.
  American journal of physiology. Heart and circulatory physiology 2016 Datar SA, Gong W, He Y, Johengen M, Kameny RJ, Raff GW, Maltepe E, Oishi PE, Fineman JR
• Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung.
  PloS one 2016 Rafikova O, Meadows ML, Kinchen JM, Mohney RP, Maltepe E, Desai AA, Yuan JX, Garcia JG, Fineman JR, Rafikov R, Black SM
• Change in Pediatric Functional Classification During Treatment and Morbidity and Mortality in Children with Pulmonary Hypertension.
  Pediatric cardiology 2016 Balkin EM, Olson ED, Robertson L, Adatia I, Fineman JR, Keller RL
• Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction.
  Journal of the American Heart Association 2016 Chen Q, Varga M, Wang X, Haddad DJ, An S, Medzikovic L, Derakhshandeh R, Kostyushev DS, Zhang Y, Clifford BT, Luu E, Danforth OM, Rafikov R, Gong W, Black SM, Suchkov SV, Fineman JR, Heiss C, …
• Recommendations for the Use of Inhaled Nitric Oxide Therapy in Premature Newborns with Severe Pulmonary Hypertension.
  The Journal of pediatrics 2015 Kinsella JP, Steinhorn RH, Krishnan US, Feinstein JA, Adatia I, Austin ED, Rosenzweig EB, Everett AD, Fineman JR, Hanna BD, Hopper RK, Humpl T, Ivy DD, Keller RL, Mullen MP, Raj JU, Wessel DL, Abman …
• Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society.
  Circulation 2015 Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing…
• Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit.
  Cell reports 2015 Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman JR, Vargas …
• Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells.
  Redox biology 2015 Rafikov R, Sun X, Rafikova O, Louise Meadows M, Desai AA, Khalpey Z, Yuan JX, Fineman JR, Black SM
• Short-Term Treprostinil Use in Infants with Congenital Diaphragmatic Hernia following Repair.
  The Journal of pediatrics 2015 Olson E, Lusk LA, Fineman JR, Robertson L, Keller RL
• Right ventricular nitric oxide signaling in an ovine model of congenital heart disease: a preserved fetal phenotype.
  American journal of physiology. Heart and circulatory physiology 2015 Kameny RJ, He Y, Morris C, Sun C, Johengen M, Gong W, Raff GW, Datar SA, Oishi PE, Fineman JR
• Longitudinal development of obesity in the post-Fontan population.
  European journal of clinical nutrition 2015 Wellnitz K, Harris IS, Sapru A, Fineman JR, Radman M
• Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress.
  Journal of cellular physiology 2014 Gross CM, Aggarwal S, Kumar S, Tian J, Kasa A, Bogatcheva N, Datar SA, Verin AD, Fineman JR, Black SM
• B-type natriuretic peptide: prognostic marker in congenital diaphragmatic hernia.
  Pediatric research 2014 Steurer MA, Moon-Grady AJ, Fineman JR, Sun CE, Lusk LA, Wai KC, Keller RL
• Are preoperative B-type natriuretic peptide levels associated with outcome after pulmonary artery banding and the double switch operation in patients with congenitally corrected transposition of the great arteries: a pilot study.
  The Journal of thoracic and cardiovascular surgery 2014 Char DS, Shiboski SC, Hanley FL, Fineman JR
• Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.
  The Journal of clinical investigation 2014 Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, …
• Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase.
  American journal of respiratory cell and molecular biology 2014 Sun X, Kumar S, Sharma S, Aggarwal S, Lu Q, Gross C, Rafikova O, Lee SG, Dasarathy S, Hou Y, Meadows ML, Han W, Su Y, Fineman JR, Black SM
• Adaptive right ventricular performance in response to acutely increased afterload in a lamb model of congenital heart disease: evidence for enhanced Anrep effect.
  American journal of physiology. Heart and circulatory physiology 2014 Johnson RC, Datar SA, Oishi PE, Bennett S, Maki J, Sun C, Johengen M, He Y, Raff GW, Redington AN, Fineman JR
• Altered reactivity and nitric oxide signaling in the isolated thoracic duct from an ovine model of congenital heart disease with increased pulmonary blood flow.
  American journal of physiology. Heart and circulatory physiology 2014 Datar SA, Oishi PE, Gong W, Bennett SH, Sun CE, Johengen M, Maki J, Johnson RC, Raff GW, Fineman JR
• Nitration of tyrosine 247 inhibits protein kinase G-1α activity by attenuating cyclic guanosine monophosphate binding.
  The Journal of biological chemistry 2014 Aggarwal S, Gross CM, Rafikov R, Kumar S, Fineman JR, Ludewig B, Jonigk D, Black SM
• Endothelin-1 stimulates catalase activity through the PKCδ-mediated phosphorylation of serine 167.
  Free radical biology & medicine 2013 Rafikov R, Kumar S, Aggarwal S, Hou Y, Kangath A, Pardo D, Fineman JR, Black SM
• Antenatal maternally-administered phosphodiesterase type 5 inhibitors normalize eNOS expression in the fetal lamb model of congenital diaphragmatic hernia.
  Journal of pediatric surgery 2013 Shue EH, Schecter SC, Gong W, Etemadi M, Johengen M, Iqbal C, Derderian SC, Oishi P, Fineman JR, Miniati D
• Preoperative B-type natriuretic peptide levels are associated with outcome after total cavopulmonary connection (Fontan).
  The Journal of thoracic and cardiovascular surgery 2013 Radman M, Keller RL, Oishi P, Datar SA, Wellnitz K, Azakie A, Hanley F, Char D, Hsu JH, Amrinovin R, Adatia I, Fineman JR
• Reactive oxygen species in pulmonary vascular remodeling.
  Comprehensive Physiology 2013 Aggarwal S, Gross CM, Sharma S, Fineman JR, Black SM
• Reply to the editor.
  The Journal of thoracic and cardiovascular surgery 2013 Amirnovin R, Oishi P, Fineman JR, Keller RL
• L-carnitine preserves endothelial function in a lamb model of increased pulmonary blood flow.
  Pediatric research 2013 Sharma S, Aramburo A, Rafikov R, Sun X, Kumar S, Oishi PE, Datar SA, Raff G, Xoinis K, Kalkan G, Fratz S, Fineman JR, Black SM
• The effect of preoperative nutritional status on postoperative outcomes in children undergoing surgery for congenital heart defects in San Francisco (UCSF) and Guatemala City (UNICAR).
  The Journal of thoracic and cardiovascular surgery 2013 Radman M, Mack R, Barnoya J, Castañeda A, Rosales M, Azakie A, Mehta N, Keller R, Datar S, Oishi P, Fineman J
• Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow.
  Antioxidants & redox signaling 2013 Sun X, Sharma S, Fratz S, Kumar S, Rafikov R, Aggarwal S, Rafikova O, Lu Q, Burns T, Dasarathy S, Wright J, Schreiber C, Radman M, Fineman JR, Black SM
• Differential responses of the right ventricle to abnormal loading conditions in vivo: possible pathophysiologic mechanisms.
  The Journal of thoracic and cardiovascular surgery 2013 Azakie A, Fineman J, He Y
• Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow.
  Journal of cellular biochemistry 2013 Kumar S, Oishi PE, Rafikov R, Aggarwal S, Hou Y, Datar SA, Sharma S, Azakie A, Fineman JR, Black SM
• Chronic inhibition of PPAR-γ signaling induces endothelial dysfunction in the juvenile lamb.
  Pulmonary pharmacology & therapeutics 2012 Sharma S, Barton J, Rafikov R, Aggarwal S, Kuo HC, Oishi PE, Datar SA, Fineman JR, Black SM
• Implications of the U.S. Food and Drug Administration warning against the use of sildenafil for the treatment of pediatric pulmonary hypertension.
  American journal of respiratory and critical care medicine 2012 Abman SH, Kinsella JP, Rosenzweig EB, Krishnan U, Kulik T, Mullen M, Wessel DL, Steinhorn R, Adatia I, Hanna B, Feinstein J, Fineman J, Raj U, Humpl T, Pediatric Pulmonary Hypertension Network (PPHNet…
• Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow.
  Pediatric research 2012 Oishi PE, Sharma S, Datar SA, Kumar S, Aggarwal S, Lu Q, Raff G, Azakie A, Hsu JH, Sajti E, Fratz S, Black SM, Fineman JR
• Endostatin, an inhibitor of angiogenesis, decreases after bidirectional superior cavopulmonary anastamosis.
  Pediatric cardiology 2012 Field-Ridley A, Heljasvaara R, Pihlajaniemi T, Adatia I, Sun C, Keller RL, Gong WH, Datar S, Oishi P, Fineman JR
• PPAR-γ regulates carnitine homeostasis and mitochondrial function in a lamb model of increased pulmonary blood flow.
  PloS one 2012 Sharma S, Sun X, Rafikov R, Kumar S, Hou Y, Oishi PE, Datar SA, Raff G, Fineman JR, Black SM
• B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion.
  The Journal of thoracic and cardiovascular surgery 2012 Amirnovin R, Keller RL, Herrera C, Hsu JH, Datar S, Karl TR, Adatia I, Oishi P, Fineman JR
• Pulmonary interstitial glycogenosis: an unrecognized etiology of persistent pulmonary hypertension of the newborn in congenital heart disease?
  Pediatric cardiology 2012 Radman MR, Goldhoff P, Jones KD, Azakie A, Datar S, Adatia I, Oishi PE, Fineman JR
• Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I.
  Free radical biology & medicine 2012 Sharma S, Sun X, Kumar S, Rafikov R, Aramburo A, Kalkan G, Tian J, Rehmani I, Kallarackal S, Fineman JR, Black SM
• Racial disparities in congenital heart disease: beyond red and blue.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2012 Soskolne G, Collins JW, Fineman JR, Fuentes-Afflick E
• Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow.
  American journal of physiology. Lung cellular and molecular physiology 2011 Datar SA, Johnson EG, Oishi PE, Johengen M, Tang E, Aramburo A, Barton J, Kuo HC, Bennett S, Xoinis K, Reel B, Kalkan G, Sajti E, Osorio O, Raff GW, Matthay MA, Fineman JR
• Usefulness of B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide as biomarkers for heart failure in young children with single ventricle congenital heart disease.
  The American journal of cardiology 2011 Lowenthal A, Camacho BV, Lowenthal S, Natal-Hernandez L, Liszewski W, Hills NK, Fineman JR, Bernstein HS
• Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration.
  Journal of cellular physiology 2011 Aggarwal S, Gross CM, Kumar S, Datar S, Oishi P, Kalkan G, Schreiber C, Fratz S, Fineman JR, Black SM
• Advances in the management of pediatric pulmonary hypertension.
  Respiratory care 2011 Oishi P, Datar SA, Fineman JR
• Pediatric pulmonary arterial hypertension: current and emerging therapeutic options.
  Expert opinion on pharmacotherapy 2011 Oishi P, Datar SA, Fineman JR
• Early determinants of pulmonary vascular remodeling in animal models of complex congenital heart disease.
  Circulation 2011 Fratz S, Fineman JR, Görlach A, Sharma S, Oishi P, Schreiber C, Kietzmann T, Adatia I, Hess J, Black SM
• Delineating the angiogenic gene expression profile before pulmonary vascular remodeling in a lamb model of congenital heart disease.
  Physiological genomics 2010 Tian J, Fratz S, Hou Y, Lu Q, Görlach A, Hess J, Schreiber C, Datar SA, Oishi P, Nechtman J, Podolsky R, She JX, Fineman JR, Black SM
• Oxidative stress and the development of endothelial dysfunction in congenital heart disease with increased pulmonary blood flow: lessons from the neonatal lamb.
  Trends in cardiovascular medicine 2010 Aggarwal S, Gross C, Fineman JR, Black SM
• Reciprocal regulation of Rac1 and PAK-1 by HIF-1alpha: a positive-feedback loop promoting pulmonary vascular remodeling.
  Antioxidants & redox signaling 2010 Diebold I, Petry A, Djordjevic T, Belaiba RS, Fineman J, Black S, Schreiber C, Fratz S, Hess J, Kietzmann T, Görlach A
• Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity.
  American journal of respiratory and critical care medicine 2010 Keller RL, Tacy TA, Hendricks-Munoz K, Xu J, Moon-Grady AJ, Neuhaus J, Moore P, Nobuhara KK, Hawgood S, Fineman JR
• Nitric oxide alterations following acute ductal constriction in the fetal lamb: a role for superoxide.
  American journal of physiology. Lung cellular and molecular physiology 2010 Hsu JH, Oishi P, Wiseman DA, Hou Y, Chikovani O, Datar S, Sajti E, Johengen MJ, Harmon C, Black SM, Fineman JR
• Perinatal changes in superoxide generation in the ovine lung: Alterations associated with increased pulmonary blood flow.
  Vascular pharmacology 2010 Sharma S, Kumar S, Wiseman DA, Kallarackal S, Ponnala S, Elgaish M, Tian J, Fineman JR, Black SM
• Mass spectroscopy and molecular modeling predict endothelial nitric oxide synthase dimer collapse by hydrogen peroxide through zinc tetrathiolate metal-binding site disruption.
  DNA and cell biology 2010 Fonseca FV, Ravi K, Wiseman D, Tummala M, Harmon C, Ryzhov V, Fineman JR, Black SM
• Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury.
  Pediatric pulmonology 2009 Reel B, Oishi PE, Hsu JH, Gildengorin G, Matthay MA, Fineman JR, Flori H
• Usefulness of various plasma biomarkers for diagnosis of heart failure in children with single ventricle physiology.
  The American journal of cardiology 2009 Shah A, Feraco AM, Harmon C, Tacy T, Fineman JR, Bernstein HS
• Effect of PPARgamma inhibition on pulmonary endothelial cell gene expression: gene profiling in pulmonary hypertension.
  Physiological genomics 2009 Tian J, Smith A, Nechtman J, Podolsky R, Aggarwal S, Snead C, Kumar S, Elgaish M, Oishi P, Göerlach A, Fratz S, Hess J, Catravas JD, Verin AD, Fineman JR, She JX, Black SM
• Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow.
  Vascular pharmacology 2009 Sharma S, Kumar S, Sud N, Wiseman DA, Tian J, Rehmani I, Datar S, Oishi P, Fratz S, Venema RC, Fineman JR, Black SM
• Peripheral arterial function in infants and young children with one-ventricle physiology and hypoxemia.
  The American journal of cardiology 2009 Natarajan S, Heiss C, Yeghiazarians Y, Fineman JR, Teitel DF, Tacy TA
• Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress.
  American journal of physiology. Lung cellular and molecular physiology 2008 Oishi PE, Wiseman DA, Sharma S, Kumar S, Hou Y, Datar SA, Azakie A, Johengen MJ, Harmon C, Fratz S, Fineman JR, Black SM
• Perioperative B-type natriuretic peptide levels predict outcome after bidirectional cavopulmonary anastomosis and total cavopulmonary connection.
  The Journal of thoracic and cardiovascular surgery 2008 Hsu JH, Oishi PE, Keller RL, Chikovani O, Karl TR, Azakie A, Adatia I, Fineman JR
• Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension.
  American journal of physiology. Lung cellular and molecular physiology 2007 Sharma S, Sud N, Wiseman DA, Carter AL, Kumar S, Hou Y, Rau T, Wilham J, Harmon C, Oishi P, Fineman JR, Black SM
• Alterations in cGMP, soluble guanylate cyclase, phosphodiesterase 5, and B-type natriuretic peptide induced by chronic increased pulmonary blood flow in lambs.
  Pediatric pulmonology 2007 Oishi P, Sharma S, Grobe A, Azakie A, Harmon C, Johengen MJ, Hsu JH, Fratz S, Black SM, Fineman JR
• B-type natriuretic peptide levels predict outcomes for children on extracorporeal life support after cardiac surgery.
  The Journal of thoracic and cardiovascular surgery 2007 Chikovani O, Hsu JH, Keller R, Karl TR, Azakie A, Adatia I, Oishi P, Fineman JR
• B-type natriuretic peptide levels predict outcome after neonatal cardiac surgery.
  The Journal of thoracic and cardiovascular surgery 2007 Hsu JH, Keller RL, Chikovani O, Cheng H, Hollander SA, Karl TR, Azakie A, Adatia I, Oishi P, Fineman JR
• Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90.
  American journal of physiology. Lung cellular and molecular physiology 2007 Sud N, Sharma S, Wiseman DA, Harmon C, Kumar S, Venema RC, Fineman JR, Black SM
• Lung antioxidant enzymes are regulated by development and increased pulmonary blood flow.
  American journal of physiology. Lung cellular and molecular physiology 2007 Sharma S, Grobe AC, Wiseman DA, Kumar S, Englaish M, Najwer I, Benavidez E, Oishi P, Azakie A, Fineman JR, Black SM
• The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow.
  American journal of physiology. Heart and circulatory physiology 2007 Lakshminrusimha S, Wiseman D, Black SM, Russell JA, Gugino SF, Oishi P, Steinhorn RH, Fineman JR
• Fibroblast growth factor-2 expression is altered in lambs with increased pulmonary blood flow and pulmonary hypertension.
  Pediatric research 2007 Wedgwood S, Devol JM, Grobe A, Benavidez E, Azakie A, Fineman JR, Black SM
• Pediatric pulmonary hypertension: Roles of endothelin-1 and nitric oxide.
  Clinical hemorheology and microcirculation 2007 Black SM, Kumar S, Wiseman D, Ravi K, Wedgwood S, Ryzhov V, Fineman JR
• Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2006 Keller RL, Moore P, Teitel D, Hawgood S, McQuitty J, Fineman JR
• Myocardial transcription factors are modulated during pathologic cardiac hypertrophy in vivo.
  The Journal of thoracic and cardiovascular surgery 2006 Azakie A, Fineman JR, He Y
• Nesiritide acutely increases pulmonary and systemic levels of nitric oxide in patients with pulmonary hypertension.
  Journal of cardiac failure 2006 Khush KK, De Marco T, Vakharia KT, Harmon C, Fineman JR, Chatterjee K, Michaels AD
• Oxidative and nitrosative stress in pediatric pulmonary hypertension: roles of endothelin-1 and nitric oxide.
  Vascular pharmacology 2006 Black SM, Fineman JR
• BNP for pediatrics--not quite ready for primetime.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2006 Oishi PE, Fineman JR
• Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase.
  American journal of physiology. Lung cellular and molecular physiology 2006 Grobe AC, Wells SM, Benavidez E, Oishi P, Azakie A, Fineman JR, Black SM
• Sp3 inhibits Sp1-mediated activation of the cardiac troponin T promoter and is downregulated during pathological cardiac hypertrophy in vivo.
  American journal of physiology. Heart and circulatory physiology 2006 Azakie A, Fineman JR, He Y
• Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: a potential perioperative marker.
  The Journal of thoracic and cardiovascular surgery 2006 Shih CY, Sapru A, Oishi P, Azakie A, Karl TR, Harmon C, Asija R, Adatia I, Fineman JR
• Nitric oxide-endothelin-1 interactions after surgically induced acute increases in pulmonary blood flow in intact lambs.
  American journal of physiology. Heart and circulatory physiology 2005 Oishi P, Azakie A, Harmon C, Fitzgerald RK, Grobe A, Xu J, Hendricks-Munoz K, Black SM, Fineman JR
• Inhaled nitric oxide induced NOS inhibition and rebound pulmonary hypertension: a role for superoxide and peroxynitrite in the intact lamb.
  American journal of physiology. Lung cellular and molecular physiology 2005 Oishi P, Grobe A, Benavidez E, Ovadia B, Harmon C, Ross GA, Hendricks-Munoz K, Xu J, Black SM, Fineman JR
• Divergent transcriptional enhancer factor-1 regulates the cardiac troponin T promoter.
  American journal of physiology. Cell physiology 2005 Azakie A, Lamont L, Fineman JR, He Y
• Endothelin-1 in congenital heart disease.
  Pediatric research 2005 Beghetti M, Black SM, Fineman JR
• Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes.
  American journal of physiology. Lung cellular and molecular physiology 2005 Lee JW, Gonzalez RF, Chapin CJ, Busch J, Fineman JR, Gutierrez JA
• Tezosentan, a combined parenteral endothelin receptor antagonist, produces pulmonary vasodilation in lambs with acute and chronic pulmonary hypertension.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2004 Fitzgerald RK, Oishi P, Ovadia B, Ross GA, Reinhartz O, Johengen MJ, Fineman JR
• Endothelial alterations during inhaled NO in lambs with pulmonary hypertension: implications for rebound hypertension.
  American journal of physiology. Lung cellular and molecular physiology 2004 Ross GA, Oishi P, Azakie A, Fratz S, Fitzgerald RK, Johengen MJ, Harmon C, Hendricks-Munoz K, Xu J, Black SM, Fineman JR
• Chronic endothelin A receptor blockade in lambs with increased pulmonary blood flow and pressure.
  American journal of physiology. Lung cellular and molecular physiology 2004 Fratz S, Meyrick B, Ovadia B, Johengen MJ, Reinhartz O, Azakie A, Ross G, Fitzgerald R, Oishi P, Hess J, Black SM, Fineman JR
• Impact of right ventricle to pulmonary artery conduit on outcome of the modified Norwood procedure.
  The Annals of thoracic surgery 2004 Azakie A, Martinez D, Sapru A, Fineman J, Teitel D, Karl TR
• Inhaled nitric oxide decreases pulmonary soluble guanylate cyclase protein levels in 1-month-old lambs.
  The Journal of thoracic and cardiovascular surgery 2004 Thelitz S, Bekker JM, Ovadia B, Stuart RB, Johengen MJ, Black SM, Fineman JR
• Phosphodiesterase-3 inhibition prevents the increase in pulmonary vascular resistance following inhaled nitric oxide withdrawal in lambs.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2004 Thelitz S, Oishi P, Sanchez LS, Bekker JM, Ovadia B, Johengen MJ, Black SM, Fineman JR
• Treatment of rebound and chronic pulmonary hypertension with oral sildenafil in an infant with congenital diaphragmatic hernia.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2004 Keller RL, Hamrick SE, Kitterman JA, Fineman JR, Hawgood S
• Increased pulmonary blood flow does not alter surfactant protein gene expression in lambs within the first week of life.
  American journal of physiology. Lung cellular and molecular physiology 2004 Lee JW, Ovadia B, Azakie A, Salas S, Goerke J, Fineman JR, Gutierrez JA
• Pharmacologic therapy for persistent pulmonary hypertension of the newborn: as "poly" as the disease itself.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2004 Oishi P, Fineman JR
• Emergence of smooth muscle cell endothelin B-mediated vasoconstriction in lambs with experimental congenital heart disease and increased pulmonary blood flow.
  Circulation 2003 Black SM, Mata-Greenwood E, Dettman RW, Ovadia B, Fitzgerald RK, Reinhartz O, Thelitz S, Steinhorn RH, Gerrets R, Hendricks-Munoz K, Ross GA, Bekker JM, Johengen MJ, Fineman JR
• Inhaled nitric oxide increases surfactant protein gene expression in the intact lamb.
  American journal of physiology. Lung cellular and molecular physiology 2003 Stuart RB, Ovadia B, Suzara VV, Ross PA, Thelitz S, Fineman JR, Gutierrez JA
• Alterations in TGF-beta1 expression in lambs with increased pulmonary blood flow and pulmonary hypertension.
  American journal of physiology. Lung cellular and molecular physiology 2003 Mata-Greenwood E, Meyrick B, Steinhorn RH, Fineman JR, Black SM
• Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension.
  American journal of physiology. Lung cellular and molecular physiology 2003 Mata-Greenwood E, Meyrick B, Soifer SJ, Fineman JR, Black SM
• Developmental differences in the shear stress-induced expression of endothelial NO synthase: changing role of AP-1.
  American journal of physiology. Lung cellular and molecular physiology 2003 Wedgwood S, Mitchell CJ, Fineman JR, Black SM
• Alterations in nitric oxide production in 8-week-old lambs with increased pulmonary blood flow.
  Pediatric research 2002 Black SM, Bekker JM, McMullan DM, Parry AJ, Ovadia B, Reinhartz O, Lakshminrushimha S, Mata-Greenwood E, Steinhorn RH, Fineman JR
• sGC and PDE5 are elevated in lambs with increased pulmonary blood flow and pulmonary hypertension.
  American journal of physiology. Lung cellular and molecular physiology 2001 Black SM, Sanchez LS, Mata-Greenwood E, Bekker JM, Steinhorn RH, Fineman JR
• Inhaled nitric oxide-induced rebound pulmonary hypertension: role for endothelin-1.
  American journal of physiology. Heart and circulatory physiology 2001 McMullan DM, Bekker JM, Johengen MJ, Hendricks-Munoz K, Gerrets R, Black SM, Fineman JR
• Inhaled nitric oxide in neonates with persistent pulmonary hypertension.
  Lancet (London, England) 2001 Tworetzky W, Bristow J, Moore P, Brook MM, Segal MR, Brasch RC, Hawgood S, Fineman JR
• Altered endothelium-dependent relaxations in lambs with high pulmonary blood flow and pulmonary hypertension.
  American journal of physiology. Heart and circulatory physiology 2001 Steinhorn RH, Russell JA, Lakshminrusimha S, Gugino SF, Black SM, Fineman JR
• Alterations in endogenous nitric oxide production after cardiopulmonary bypass in lambs with normal and increased pulmonary blood flow.
  Circulation 2000 McMullan DM, Bekker JM, Parry AJ, Johengen MJ, Kon A, Heidersbach RS, Black SM, Fineman JR
• Transthoracic intracardiac catheters in pediatric patients recovering from congenital heart defect surgery: associated complications and outcomes.
  Critical care medicine 2000 Flori HR, Johnson LD, Hanley FL, Fineman JR
• Management and outcomes of delayed sternal closure after cardiac surgery in neonates and infants.
  Critical care medicine 2000 McElhinney DB, Reddy VM, Parry AJ, Johnson L, Fineman JR, Hanley FL
• Pulmonary blood flow alters nitric oxide production in patients undergoing device closure of atrial septal defects.
  Journal of the American College of Cardiology 2000 Tworetzky W, Moore P, Bekker JM, Bristow J, Black SM, Fineman JR
• Altered regulation of the ET-1 cascade in lambs with increased pulmonary blood flow and pulmonary hypertension.
  Pediatric research 2000 Black SM, Bekker JM, Johengen MJ, Parry AJ, Soifer SJ, Fineman JR
• Inhaled nitric oxide inhibits NOS activity in lambs: potential mechanism for rebound pulmonary hypertension.
  The American journal of physiology 1999 Black SM, Heidersbach RS, McMullan DM, Bekker JM, Johengen MJ, Fineman JR
• The pathophysiology of pulmonary hypertension in congenital heart disease.
  Artificial organs 1999 Steinhorn RH, Fineman JR
• Alveolar capillary dysplasia: diagnostic potential for cardiac catheterization.
  Journal of perinatology : official journal of the California Perinatal Association 1999 Hintz SR, Vincent JA, Pitlick PT, Fineman JR, Steinhorn RH, Kim GE, Benitz WE
• Inhaled nitric oxide, oxygen, and alkalosis: dose-response interactions in a lamb model of pulmonary hypertension.
  Pediatric pulmonology 1999 Heidersbach RS, Johengen MJ, Bekker JM, Fineman JR
• Altered endothelial function in lambs with pulmonary hypertension and acute lung injury.
  Pediatric pulmonology 1999 Fineman JR, Wong J, Mikhailov T, Vanderford PA, Jerome HE, Soifer SJ
• Endothelin receptor blockade prevents the rise in pulmonary vascular resistance after cardiopulmonary bypass in lambs with increased pulmonary blood flow.
  The Journal of thoracic and cardiovascular surgery 1999 Petrossian E, Parry AJ, Reddy VM, Akkersdijk GP, McMullan DM, Thompson L, Hendricks-Munoz KD, Hallak H, Hanley FL, Fineman JR
• Role of the endothelium in placental dysfunction after fetal cardiac bypass.
  The Journal of thoracic and cardiovascular surgery 1999 Reddy VM, McElhinney DB, Rajasinghe HA, Liddicoat JR, Hendricks-Munoz K, Fineman JR, Hanley FL
• Endothelin-receptor blockade does not alter closure of the ductus arteriosus.
  The American journal of physiology 1998 Fineman JR, Takahashi Y, Roman C, Clyman RI
• Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension.
  The American journal of physiology 1998 Black SM, Fineman JR, Steinhorn RH, Bristow J, Soifer SJ
• Increased pulmonary blood flow alters the molecular regulation of vascular reactivity in the lamb.
  Chest 1998 Black S, Fineman J, Johengen M, Bristow J, Soifer S
• The effects of inhaled nitric oxide on postoperative pulmonary hypertension in infants and children undergoing surgical repair of congenital heart disease.
  Anesthesia and analgesia 1998 Russell IA, Zwass MS, Fineman JR, Balea M, Rouine-Rapp K, Brook M, Hanley FL, Silverman NH, Cahalan MK
• Models of persistent pulmonary hypertension of the newborn (PPHN) and the role of cyclic guanosine monophosphate (GMP) in pulmonary vasorelaxation.
  Seminars in perinatology 1997 Steinhorn RH, Morin FC, Fineman JR
• Inhaled nitric oxide enhances oxygenation but not survival in infants with alveolar capillary dysplasia.
  The Journal of pediatrics 1997 Steinhorn RH, Cox PN, Fineman JR, Finer NN, Rosenberg EM, Silver MM, Tyebkhan J, Zwass MS, Morin FC
• Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group.
  The New England journal of medicine 1997 Roberts JD, Fineman JR, Morin FC, Shaul PW, Rimar S, Schreiber MD, Polin RA, Zwass MS, Zayek MM, Gross I, Heymann MA, Zapol WM
• Post-cardiopulmonary bypass pulmonary hypertension in lambs with increased pulmonary blood flow. A role for endothelin 1.
  Circulation 1997 Reddy VM, Hendricks-Munoz KD, Rajasinghe HA, Petrossian E, Hanley FL, Fineman JR
• Hemodynamic effects of epinephrine, bicarbonate and calcium in the early postnatal period in a lamb model of single-ventricle physiology created in utero.
  Journal of the American College of Cardiology 1996 Reddy VM, Liddicoat JR, McElhinney DB, Fineman JR, Klein JR, Chang R, Hanley FL
• Altered endothelium-dependent responses in lambs with pulmonary hypertension and increased pulmonary blood flow.
  The American journal of physiology 1996 Reddy VM, Wong J, Liddicoat JR, Johengen M, Chang R, Fineman JR
• Exogenous endothelin-1 causes renal vasodilation in the fetal lamb.
  The Journal of urology 1996 Bogaert GA, Kogan BA, Mevorach RA, Wong J, Gluckman GR, Fineman JR, Heymann MA
• Fetal model of single ventricle physiology: hemodynamic effects of oxygen, nitric oxide, carbon dioxide, and hypoxia in the early postnatal period.
  The Journal of thoracic and cardiovascular surgery 1996 Reddy VM, Liddicoat JR, Fineman JR, McElhinney DB, Klein JR, Hanley FL
• Endothelin receptor blockade does not alter the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs.
  Pediatric research 1996 Winters JW, Wong J, Van Dyke D, Johengen M, Heymann MA, Fineman JR
• Invited editorial on "Antenatal betamethasone therapy augments nitric oxide-mediated relaxation of preterm ovine pulmonary veins".
  Journal of applied physiology (Bethesda, Md. : 1985) 1996 Fineman JR, Taeusch HW
• Endothelin-1 vasoactive responses in lambs with pulmonary hypertension and increased pulmonary blood flow.
  The American journal of physiology 1995 Wong J, Reddy VM, Hendricks-Munoz K, Liddicoat JR, Gerrets R, Fineman JR
• In utero placement of aortopulmonary shunts. A model of postnatal pulmonary hypertension with increased pulmonary blood flow in lambs.
  Circulation 1995 Reddy VM, Meyrick B, Wong J, Khoor A, Liddicoat JR, Hanley FL, Fineman JR
• Inhaled nitric oxide therapy for persistent pulmonary hypertension of the newborn.
  Acta paediatrica Japonica : Overseas edition 1995 Fineman JR, Zwass MS
• Endothelinb receptor agonists produce pulmonary vasodilation in intact newborn lambs with pulmonary hypertension.
  Journal of cardiovascular pharmacology 1995 Wong J, Vanderford PA, Winters J, Soifer SJ, Fineman JR
• Regulation of pulmonary vascular tone in the perinatal period.
  Annual review of physiology 1995 Fineman JR, Soifer SJ, Heymann MA
• Inhaled nitric oxide in congenital hypoplasia of the lungs due to diaphragmatic hernia or oligohydramnios.
  Pediatrics 1994 Karamanoukian HL, Glick PL, Zayek M, Steinhorn RH, Zwass MS, Fineman JR, Morin FC
• Developmental effects of endothelin-1 on the pulmonary circulation in sheep.
  Pediatric research 1994 Wong J, Vanderford PA, Fineman JR, Soifer SJ
• Use of ATP-MgCl2 in the evaluation and treatment of children with pulmonary hypertension secondary to congenital heart defects.
  Circulation 1994 Brook MM, Fineman JR, Bolinger AM, Wong AF, Heymann MA, Soifer SJ
• Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs.
  The Journal of clinical investigation 1994 Fineman JR, Wong J, Morin FC, Wild LM, Soifer SJ
• The role of endothelin and endothelin receptor subtypes in regulation of fetal pulmonary vascular tone.
  Pediatric research 1994 Wong J, Fineman JR, Heymann MA
• HA1004, an intracellular calcium antagonist, selectively attenuates pulmonary hypertension in newborn lambs.
  Journal of cardiovascular pharmacology 1994 Crowley MR, Fineman JR, Soifer SJ
• Diethylamine/nitric oxide (NO) adduct, an NO donor, produces potent pulmonary and systemic vasodilation in intact newborn lambs.
  Journal of cardiovascular pharmacology 1994 Vanderford PA, Wong J, Chang R, Keefer LK, Soifer SJ, Fineman JR
• Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb.
  The American journal of physiology 1993 Wong J, Vanderford PA, Fineman JR, Chang R, Soifer SJ
• Hyperoxia and alkalosis produce pulmonary vasodilation independent of endothelium-derived nitric oxide in newborn lambs.
  Pediatric research 1993 Fineman JR, Wong J, Soifer SJ
• Endothelin-1 does not mediate acute hypoxic pulmonary vasoconstriction in the intact newborn lamb.
  Journal of cardiovascular pharmacology 1993 Wong J, Vanderford PA, Winters JW, Chang R, Soifer SJ, Fineman JR
• M&B 22948, a cGMP phosphodiesterase inhibitor, is a pulmonary vasodilator in lambs.
  The American journal of physiology 1993 Braner DA, Fineman JR, Chang R, Soifer SJ
• EDRF inhibition attenuates the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs.
  Journal of applied physiology (Bethesda, Md. : 1985) 1992 Moore P, Velvis H, Fineman JR, Soifer SJ, Heymann MA
• K+ channel pulmonary vasodilation in fetal lambs: role of endothelium-derived nitric oxide.
  Journal of applied physiology (Bethesda, Md. : 1985) 1992 Chang JK, Moore P, Fineman JR, Soifer SJ, Heymann MA
• EDRF inhibition augments pulmonary hypertension in intact newborn lambs.
  The American journal of physiology 1992 Fineman JR, Chang R, Soifer SJ
• L-Arginine, a precursor of EDRF in vitro, produces pulmonary vasodilation in lambs.
  The American journal of physiology 1991 Fineman JR, Chang R, Soifer SJ
• In vivo attenuation of endothelium-dependent pulmonary vasodilation by methylene blue.
  Journal of applied physiology (Bethesda, Md. : 1985) 1991 Fineman JR, Crowley MR, Heymann MA, Soifer SJ
• N omega-nitro-L-arginine attenuates endothelium-dependent pulmonary vasodilation in lambs.
  The American journal of physiology 1991 Fineman JR, Heymann MA, Soifer SJ
• Effects of vasoactive drugs on thromboxane A2 mimetic-induced pulmonary hypertension in newborn lambs.
  Pediatric research 1991 Crowley MR, Fineman JR, Soifer SJ
• The role of pulmonary vascular endothelium in perinatal pulmonary circulatory regulation.
  Seminars in perinatology 1991 Fineman JR, Soifer SJ, Heymann MA
• Selective pulmonary vasodilation with ATP-MgCl2 during pulmonary hypertension in lambs.
  Journal of applied physiology (Bethesda, Md. : 1985) 1990 Fineman JR, Crowley MR, Soifer SJ