Jeffrey Bush, PhD
Professor
Cell and Tissue Biology
School of Dentistry

Our lab has NIH-sponsored projects focused on understanding development in multiple organ systems that include the craniofacial complex, the brain, the trachea and the esophagus. We have a highly collaborative group of researchers that are committed to understanding fundamental cellular and genetic mechanisms that underlie development and disease. We have made discoveries that reveal the intricate mechanisms of EPH/EPHRIN signaling during development, have elucidated how tissue fusion occurs in multiple aspects of development, and have revealed early transcriptional networks that control tracheal development. To make these discoveries, we have developed new live imaging approaches, novel mouse genetics reagents, and the first human induced pluripotent stem cell model of a congenital craniofacial disease.

• Alternative cleavage and polyadenylation of the Ccnb1 mRNA defines accumulation of cyclin protein during the meiotic cell cycle.
  Nucleic acids research 2024 Wang X, Leung FS, Bush JO, Conti M
• A Suite of Mouse Reagents for Studying Amelogenesis.
  bioRxiv : the preprint server for biology 2023 Wald T, Verma A, Cooley V, Marangoni P, Cazares O, Sharir A, Sandoval EJ, Sung D, Najibi H, Drennon TY, Bush JO, Joester D, Klein OD
• Exome sequencing efficacy and phenotypic expansions involving esophageal atresia/tracheoesophageal fistula plus.
  American journal of medical genetics. Part A 2022 Sy MR, Chauhan J, Prescott K, Imam A, Kraus A, Beleza A, Salkeld L, Hosdurga S, Parker M, Vasudevan P, Islam L, Goel H, Bain N, Park SM, Mohammed S, Dieterich K, Coutton C, Satre V, Vieville G, …
• Investigating Cell Fate Specification upon Nkx2-1Loss.
  The FASEB Journal 2022 Marisol A. O'Neill, Jeffrey O. Bush
• Cellular and molecular mechanisms of EPH/EPHRIN signaling in evolution and development.
  Current topics in developmental biology 2022 Bush JO
• Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial development.
  Developmental dynamics : an official publication of the American Association of Anatomists 2022 Mincer ST, Niethamer TK, Teng T, Bush JO, Percival CJ
• Cellular and Molecular Regulation of Upper Lip Fusion.
  The FASEB Journal 2021 Camilla Teng, Teng Teng, Jeffrey Bush
• Effects of EPHB receptors on facial morphology: non-additive interactions during mouse facial development.
  The FASEB Journal 2021 Sarah Mincer, Terren Niethamer, Teng Teng, Jeffrey Bush, Christopher Percival
• Separation of the trachea and esophagus is coupled to identity specification by NKX2-1-mediated regulation of EPH/EPHRIN signaling and cell sorting.
  The FASEB Journal 2021 Ace Lewis, Akela Kuwahara, Jeffrey Bush
• NMDA receptors control development of somatosensory callosal axonal projections.
  eLife 2021 Zhou J, Lin Y, Huynh T, Noguchi H, Bush JO, Pleasure SJ
• YAP/TAZ Regulate Elevation and Bone Formation of the Mouse Secondary Palate.
  Journal of dental research 2020 Goodwin AF, Chen CP, Vo NT, Bush JO, Klein OD
• Forced to communicate: Integration of mechanical and biochemical signaling in morphogenesis.
  Current opinion in cell biology 2020 Kindberg A, Hu JK, Bush JO
• The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice Within a Research Community.
  G3 (Bethesda, Md.) 2020 Wall E, Scoles J, Joo A, Klein O, Quinonez C, Bush JO, Martin GR, Laird DJ
• Morphometric Analysis of Efnb1 Dependent Palate Growth.
  The FASEB Journal 2020 Marisol Ann O'Neill, Christopher J. Percival, Jeffrey O. Bush
• Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome.
  PLoS genetics 2020 Niethamer TK, Teng T, Franco M, Du YX, Percival CJ, Bush JO
• Hypertelorism of Efnb1 Null Mice Occurs Independently of Changes to Underlying Brain Shape.
  The FASEB Journal 2019 Christopher J Percival, Jay Devine, Terren Niethamer, Jeffrey Bush
• Cellular organization and boundary formation in craniofacial development.
  Genesis (New York, N.Y. : 2000) 2019 Kindberg AA, Bush JO
• WITHDRAWN: Editorial Introduction.
  Developmental biology 2019 Bush JO, Andersson ER
• Editorial: Signaling pathways instruct the blueprint of life.
  Developmental biology 2018 Bush JO, Andersson ER
• Getting direction(s): The Eph/ephrin signaling system in cell positioning.
  Developmental biology 2018 Niethamer TK, Bush JO
• Live Imaging of Mouse Secondary Palate Fusion.
  Journal of visualized experiments : JoVE 2017 Kim S, Prochazka J, Bush JO
• Cellular dynamics of tissue fusion in craniofacial development and orofacial clefting.
  The FASEB Journal 2017 Jeffrey O. Bush, Seungil Kim, Bronwyn Hagan
• EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells.
  Stem cell reports 2017 Niethamer TK, Larson AR, O'Neill AK, Bershteyn M, Hsiao EC, Klein OD, Pomerantz JH, Bush JO
• Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation.
  The Journal of cell biology 2016 O'Neill AK, Kindberg AA, Niethamer TK, Larson AR, Ho HH, Greenberg ME, Bush JO
• From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models.
  Current topics in developmental biology 2015 Goodwin AF, Kim R, Bush JO, Klein OD
• Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature.
  Developmental biology 2015 Lewis AE, Hwa J, Wang R, Soriano P, Bush JO
• Convergence and extrusion are required for normal fusion of the mammalian secondary palate.
  PLoS biology 2015 Kim S, Lewis AE, Singh V, Ma X, Adelstein R, Bush JO
• Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate.
  Developmental dynamics : an official publication of the American Association of Anatomists 2014 Agrawal P, Wang M, Kim S, Lewis AE, Bush JO
• Cell intercalation and migration mediated by actin contractility are key cellular behaviors in fusion of the mammalian secondary palate (344.2).
  The FASEB Journal 2014 Jeffrey Bush, Seungil Kim
• The society of craniofacial genetics and developmental biology 35th annual meeting.
  American Journal of Medical Genetics Part A 2013 Ophir D. Klein, Jeffrey O. Bush, Sarah M. Knox, Andrew H. Jheon, Dwight R. Cordero, Joan T. Richtsmeier
• The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling.
  Developmental biology 2013 Lewis AE, Vasudevan HN, O'Neill AK, Soriano P, Bush JO
• Ephrin B1 maintains apical adhesion of neural progenitors.
  Development (Cambridge, England) 2013 Arvanitis DN, Béhar A, Tryoen-Tóth P, Bush JO, Jungas T, Vitale N, Davy A
• Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development.
  Development (Cambridge, England) 2012 Bush JO, Jiang R
• Eph/ephrin signaling: genetic, phosphoproteomic, and transcriptomic approaches.
  Seminars in cell & developmental biology 2011 Bush JO, Soriano P
• Ephrin-B signaling in craniofacial development and disease.
  The FASEB Journal 2011 Jeffrey Ohmann Bush, Philippe Soriano
• Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries.
  Genes & development 2010 Bush JO, Soriano P
• Analysis of signaling downstream of ephrin-B1 during development.
  Developmental Biology 2009 Jeffrey O. Bush, Philippe Soriano
• Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism.
  Genes & development 2009 Bush JO, Soriano P
• The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival.
  Genesis (New York, N.Y. : 2000) 2007 Chen J, Bush JO, Ovitt CE, Lan Y, Jiang R
• Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome.
  PLoS biology 2006 Davy A, Bush JO, Soriano P
• Development of the upper lip: Morphogenetic and molecular mechanisms.
  Developmental Dynamics 2006 Rulang Jiang, Jeffrey O. Bush, Andrew C. Lidral
• Development of the upper lip: morphogenetic and molecular mechanisms.
  Developmental dynamics : an official publication of the American Association of Anatomists 2006 Jiang R, Bush JO, Lidral AC
• Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice.
  Developmental dynamics : an official publication of the American Association of Anatomists 2006 Lan Y, Ryan RC, Zhang Z, Bullard SA, Bush JO, Maltby KM, Lidral AC, Jiang R
• The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Bush JO, Lan Y, Jiang R
• The T-box gene Tbx10 exhibits a uniquely restricted expression pattern during mouse embryogenesis.
  Gene expression patterns : GEP 2003 Bush JO, Maltby KM, Cho ES, Jiang R