Jeff Simko, MD, PhD
Professor
Pathology
School of Medicine

Education & Training

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• M.D. School of Medicine University of North Carolina 1996

Websites

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• Clinical Profile at UCSF Medical Center (ucsfhealth.org)

Publications (96)

Top publication keywords:
Biomarkers, TumorNeoplasm Recurrence, LocalGene Expression ProfilingProstatectomyAdenocarcinoma, MucinousMagnetic Resonance SpectroscopyProstate-Specific AntigenAdenocarcinomaNeoplasm GradingBiopsy, Large-Core NeedleCarcinomaWatchful WaitingProstateProstatic NeoplasmsKallikreins

• Mixed Supervision of Histopathology Improves Prostate Cancer Classification from MRI.
  IEEE transactions on medical imaging 2024 Rajagopal A, Westphalen AC, Velarde N, Simko JP, Nguyen H, Hope TA, Larson PEZ, Magudia K
• External Validation of a Digital Pathology-based Multimodal Artificial Intelligence Architecture in the NRG/RTOG 9902 Phase 3 Trial.
  European urology oncology 2024 Ross AE, Zhang J, Huang HC, Yamashita R, Keim-Malpass J, Simko JP, DeVries S, Morgan TM, Souhami L, Dobelbower MC, McGinnis LS, Jones CU, Dess RT, Zeitzer KL, Choi K, Hartford AC, Michalski JM, Raben …
• The impact of genomic biomarkers on a clinical risk prediction model for upgrading/upstaging among men with favorable-risk prostate cancer.
  Cancer 2024 Braun AE, Chan JM, Neuhaus J, Cowan JE, Kenfield SA, Van Blarigan EL, Tenggara I, Broering JM, Simko JP, Carroll PR, Cooperberg MR
• High expression of Trop2 is associated with aggressive localized prostate cancer and is a candidate urinary biomarker.
  Scientific reports 2024 Liu S, Hawley SJ, Kunder CA, Hsu EC, Shen M, Westphalen L, Auman H, Newcomb LF, Lin DW, Nelson PS, Feng Z, Tretiakova MS, True LD, Vakar-Lopez F, Carroll PR, Simko J, Gleave ME, Troyer DA, McKenney JK…
• Large cribriform glands (> 0.25 mm diameter) as a predictor of adverse pathology in men with Grade Group 2 prostate cancer.
  Histopathology 2023 Greenland NY, Cowan JE, Stohr BA, Simko JP, Carroll PR, Chan E

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• Positive NKX3.1 as a diagnostic pitfall for prostate cancer in extramammary Paget's disease of genitourinary sites.
  Histopathology 2023 Chen CV, Francois RA, Mully TW, Sangoi A, LeBoit PE, Simko JP, Chan E
• First-in-human Evaluation of a Prostate-specific Membrane Antigen-targeted Near-infrared Fluorescent Small Molecule for Fluorescence-based Identification of Prostate Cancer in Patients with High-risk Prostate Cancer Undergoing Robotic-assisted Prostatectomy.
  European urology oncology 2023 Nguyen HG, van den Berg NS, Antaris AL, Xue L, Greenberg S, Rosenthal JW, Muchnik A, Klaassen A, Simko JP, Dutta S, Sorger JM, Munster P, Carroll PR
• Transcriptomic Heterogeneity of Expansile Cribriform and Other Gleason Pattern 4 Prostate Cancer Subtypes.
  European urology oncology 2023 Chappidi MR, Sjöström M, Greenland NY, Cowan JE, Baskin AS, Shee K, Simko JP, Chan E, Stohr BA, Washington SL, Nguyen HG, Quigley DA, Davicioni E, Feng FY, Carroll PR, Cooperberg MR
• Artificial Intelligence Predictive Model for Hormone Therapy Use in Prostate Cancer.
  NEJM evidence 2023 Spratt DE, Tang S, Sun Y, Huang HC, Chen E, Mohamad O, Armstrong AJ, Tward JD, Nguyen PL, Lang JM, Zhang J, Mitani A, Simko JP, DeVries S, van der Wal D, Pinckaers H, Monson JM, Campbell HA, Wallace J…
• Genomic Classifier Performance in Intermediate-Risk Prostate Cancer: Results From NRG Oncology/RTOG 0126 Randomized Phase 3 Trial.
  International journal of radiation oncology, biology, physics 2023 Spratt DE, Liu VYT, Michalski J, Davicioni E, Berlin A, Simko JP, Efstathiou JA, Tran PT, Sandler HM, Hall WA, Thompson DJS, Parliament MB, Dayes IS, Correa RJM, Robertson JM, Gore EM, Doncals DE, …
• Artificial Intelligence Predictive Model for Hormone Therapy Use in Prostate Cancer.
  Research square 2023 Spratt DE, Tang S, Sun Y, Huang HC, Chen E, Mohamad O, Armstrong AJ, Tward JD, Nguyen PL, Lang JM, Zhang J, Mitani A, Simko JP, DeVries S, van der Wal D, Pinckaers H, Monson JM, Campbell HA, Wallace J…
• Renaming Grade Group 1 Prostate "Cancer" From a Pathology Perspective: A Call for Multidisciplinary Discussion.
  Advances in anatomic pathology 2023 Paner GP, Zhou M, Simko JP, Eggener SE, van der Kwast T
• Author Correction: Prostate cancer therapy personalization via multi-modal deep learning on randomized phase III clinical trials.
  NPJ digital medicine 2023 Esteva A, Feng J, van der Wal D, Huang SC, Simko JP, DeVries S, Chen E, Schaeffer EM, Morgan TM, Sun Y, Ghorbani A, Naik N, Nathawani D, Socher R, Michalski JM, Roach M, Pisansky TM, Monson JM, Naz F,…
• Prostate cancer lesion detection, volume quantification and high-grade cancer differentiation using cancer risk maps derived from multiparametric MRI with histopathology as the reference standard.
  Magnetic resonance imaging 2023 Gibbons M, Simko JP, Carroll PR, Noworolski SM
• Protocol for a 4-arm randomized controlled trial testing remotely delivered exercise-only, diet-only, and exercise + diet interventions among men with prostate cancer treated with radical prostatectomy (Prostate 8-II).
  Contemporary clinical trials 2023 Van Blarigan EL, Chan JM, Sanchez A, Zhang L, Winters-Stone K, Liu V, Macaire G, Panchal N, Graff RE, Tenggara I, Luke A, Simko JP, Cooperberg MR, Carroll PR, Kenfield SA
• Analysis of a Biopsy-Based Genomic Classifier in High-Risk Prostate Cancer: Meta-Analysis of the NRG Oncology/Radiation Therapy Oncology Group 9202, 9413, and 9902 Phase 3 Randomized Trials.
  International journal of radiation oncology, biology, physics 2022 Nguyen PL, Huang HR, Spratt DE, Davicioni E, Sandler HM, Shipley WU, Efstathiou JA, Simko JP, Pollack A, Dicker AP, Roach M, Rosenthal SA, Zeitzer KL, Mendez LC, Hartford AC, Hall WA, Desai AB, …
• Prostate Cancer in Male-to-Female Transgender Individuals: Histopathologic Findings and Association With Gender-affirming Hormonal Therapy.
  The American journal of surgical pathology 2022 Baraban E, Ding CC, White M, Vohra P, Simko J, Boyle K, Guo C, Zhang M, Dobs A, Ketheeswaran S, Liang F, Epstein JI
• Prostate cancer therapy personalization via multi-modal deep learning on randomized phase III clinical trials.
  NPJ digital medicine 2022 Esteva A, Feng J, van der Wal D, Huang SC, Simko JP, DeVries S, Chen E, Schaeffer EM, Morgan TM, Sun Y, Ghorbani A, Naik N, Nathawani D, Socher R, Michalski JM, Roach M, Pisansky TM, Monson JM, Naz F,…
• The Influence of the Pretreatment Immune State on Response to Radiation Therapy in High-Risk Prostate Cancer: A Validation Study From NRG/RTOG 0521.
  International journal of radiation oncology, biology, physics 2022 Hall WA, Karrison TG, Rosenthal SA, Amin MB, Gomella LG, Purdy JA, Sartor AO, Michalski JM, Garzotto MG, Bergom C, Jani AB, Lawton CAF, Simko JP, Moore JK, Gore EM, Lee WR, Nguyen PL, Danielson BL, …
• An exploration in pitfalls in interpreting SDHB immunohistochemistry.
  Histopathology 2022 Ding CC, Chan S, Mak J, Umetsu SE, Simko JP, Ruiz-Cordero R, Saunders T, Chan E
• Analysis of separate training and validation radical prostatectomy cohorts identifies 0.25 mm diameter as an optimal definition for "large" cribriform prostatic adenocarcinoma.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2022 Chan E, McKenney JK, Hawley S, Corrigan D, Auman H, Newcomb LF, Boyer HD, Carroll PR, Cooperberg MR, Klein E, Fazli L, Gleave ME, Hurtado-Coll A, Simko JP, Nelson PS, Thompson IM, Tretiakova MS, …
• US lesion visibility predicts clinically significant upgrade of prostate cancer by systematic biopsy.
  Abdominal radiology (New York) 2022 Velarde N, Westphalen AC, Nguyen HG, Neuhaus J, Shinohara K, Simko JP, Larson PE, Magudia K
• Molecular risk classifier score and biochemical recurrence risk are associated with cribriform pattern type in Gleason 3+4=7 prostate cancer.
  Investigative and clinical urology 2022 Greenland NY, Cooperberg MR, Wong AC, Chan E, Carroll PR, Simko JP, Stohr BA
• Differential immunohistochemical and molecular profiling of conventional and aggressive components of chromophobe renal cell carcinoma: pitfalls for diagnosis.
  Human pathology 2021 Chen CV, Croom NA, Simko JP, Stohr BA, Chan E
• Identification of prostate cancer using multiparametric MR imaging characteristics of prostate tissues referenced to whole mount histopathology.
  Magnetic resonance imaging 2021 Gibbons M, Starobinets O, Simko JP, Kurhanewicz J, Carroll PR, Noworolski SM
• Cell-Free DNA Detection of Tumor Mutations in Heterogeneous, Localized Prostate Cancer Via Targeted, Multiregion Sequencing.
  JCO precision oncology 2021 Chen E, Cario CL, Leong L, Lopez K, Márquez CP, Li PS, Oropeza E, Tenggara I, Cowan J, Simko JP, Kageyama R, Wells DK, Chan JM, Friedlander T, Aggarwal R, Paris PL, Feng F, Carroll PR, Witte JS
• Residual Benign Prostate Glandular Tissue after Radical Prostatectomy is Not Associated with the Development of Detectable Postoperative Serum Prostate Specific Antigen.
  The Journal of urology 2021 Greenberg SA, Washington SL, Lonergan PE, Cowan JE, Baskin AS, Nguyen HG, Odisho AY, Simko JP, Carroll PR
• Validation of a 22-Gene Genomic Classifier in Patients With Recurrent Prostate Cancer: An Ancillary Study of the NRG/RTOG 9601 Randomized Clinical Trial.
  JAMA oncology 2021 Feng FY, Huang HC, Spratt DE, Zhao SG, Sandler HM, Simko JP, Davicioni E, Nguyen PL, Pollack A, Efstathiou JA, Dicker AP, Todorovic T, Margrave J, Liu YS, Dabbas B, Thompson DJS, Das R, Dignam JJ, …
• Cell-free DNA concentration and fragment size as a biomarker for prostate cancer.
  Scientific reports 2021 Chen E, Cario CL, Leong L, Lopez K, Márquez CP, Chu C, Li PS, Oropeza E, Tenggara I, Cowan J, Simko JP, Chan JM, Friedlander T, Wyatt AW, Aggarwal R, Paris PL, Carroll PR, Feng F, Witte JS
• Acute Invasive Rhino-Orbital Mucormycosis in a Patient With COVID-19-Associated Acute Respiratory Distress Syndrome.
  Ophthalmic plastic and reconstructive surgery 2021 Mekonnen ZK, Ashraf DC, Jankowski T, Grob SR, Vagefi MR, Kersten RC, Simko JP, Winn BJ
• Multiple Tissue Biomarkers Independently and Additively Predict Prostate Cancer Pathology Outcomes.
  European urology 2020 Cooperberg MR, Cowan JE, Lindquist KJ, Kobayashi Y, Simko JP, Bengtsson H, Singh K, Ngo V, Avila A, Newcomb LF, Tretriakova M, Lin DW, Stone S, Carroll PR, Paris PL
• Prostate biopsy histopathologic features correlate with a commercial gene expression assay's reclassification of patient NCCN risk category.
  The Prostate 2020 Greenland NY, Cowan JE, Chan E, Carroll PR, Stohr BA, Simko JP
• A machine learning approach to optimizing cell-free DNA sequencing panels: with an application to prostate cancer.
  BMC cancer 2020 Cario CL, Chen E, Leong L, Emami NC, Lopez K, Tenggara I, Simko JP, Friedlander TW, Li PS, Paris PL, Carroll PR, Witte JS
• The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma.
  The American journal of surgical pathology 2020 van Leenders GJLH, van der Kwast TH, Grignon DJ, Evans AJ, Kristiansen G, Kweldam CF, Litjens G, McKenney JK, Melamed J, Mottet N, Paner GP, Samaratunga H, Schoots IG, Simko JP, Tsuzuki T, Varma M, …
• Expansile cribriform Gleason pattern 4 has histopathologic and molecular features of aggressiveness and greater risk of biochemical failure compared to glomerulation Gleason pattern 4.
  The Prostate 2020 Greenland NY, Cowan JE, Zhang L, Carroll PR, Chan E, Stohr BA, Simko JP
• Development and pilot evaluation of a personalized decision support intervention for low risk prostate cancer patients.
  Cancer medicine 2019 Belkora J, Chan JM, Cooperberg MR, Neuhaus J, Stupar L, Weinberg T, Broering JM, Tenggara I, Cowan JE, Rosenfeld S, Kenfield SA, Van Blarigan EL, Simko JP, Witte J, Carroll PR
• A 17-Gene Genomic Prostate Score as a Predictor of Adverse Pathology in Men on Active Surveillance.
  The Journal of urology 2019 Kornberg Z, Cooperberg MR, Cowan JE, Chan JM, Shinohara K, Simko JP, Tenggara I, Carroll PR
• Identification and Characterization of Circulating Tumor Cells in Men Who have Undergone Prostatectomy for Clinically Localized, High Risk Prostate Cancer.
  The Journal of urology 2019 Friedlander TW, Welty C, Anantharaman A, Schonhoft JD, Jendrisak A, Lee J, Li P, Hough J, Stromlund A, Edwards M, Sangar S, Kobayashi Y, Simko J, Farrokhian N, Lindquist K, Greene S, Ontiveros P, Graf…
• Decipher identifies men with otherwise clinically favorable-intermediate risk disease who may not be good candidates for active surveillance.
  Prostate cancer and prostatic diseases 2019 Herlemann A, Huang HC, Alam R, Tosoian JJ, Kim HL, Klein EA, Simko JP, Chan JM, Lane BR, Davis JW, Davicioni E, Feng FY, McCue P, Kim H, Den RB, Bismar TA, Carroll PR, Cooperberg MR
• TP53 structural variants in metastatic prostatic carcinoma.
  PloS one 2019 Sirohi D, Devine P, Grenert JP, van Ziffle J, Simko JP, Stohr BA
• Correlation of a Commercial Genomic Risk Classifier with Histological Patterns in Prostate Cancer.
  The Journal of urology 2019 Greenland NY, Zhang L, Cowan JE, Carroll PR, Stohr BA, Simko JP
• Phase I Study of CTT1057, an 18F-Labeled Imaging Agent with Phosphoramidate Core Targeting Prostate-Specific Membrane Antigen in Prostate Cancer.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2018 Behr SC, Aggarwal R, VanBrocklin HF, Flavell RR, Gao K, Small EJ, Blecha J, Jivan S, Hope TA, Simko JP, Kurhanewicz J, Noworolski SM, Korn NJ, De Los Santos R, Cooperberg MR, Carroll PR, Nguyen HG, …
• Neoadjuvant sipuleucel-T induces both Th1 activation and immune regulation in localized prostate cancer.
  Oncoimmunology 2018 Hagihara K, Chan S, Zhang L, Oh DY, Wei XX, Simko J, Fong L
• Diagnostic Accuracy of 68Ga-PSMA-11 PET/MRI Compared with Multiparametric MRI in the Detection of Prostate Cancer.
  Radiology 2018 Hicks RM, Simko JP, Westphalen AC, Nguyen HG, Greene KL, Zhang L, Carroll PR, Hope TA
• Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer.
  JCI insight 2018 Su Y, Liu Y, Behrens CR, Bidlingmaier S, Lee NK, Aggarwal R, Sherbenou DW, Burlingame AL, Hann BC, Simko JP, Premasekharan G, Paris PL, Shuman MA, Seo Y, Small EJ, Liu B
• Comparing Prognostic Utility of a Single-marker Immunohistochemistry Approach with Commercial Gene Expression Profiling Following Radical Prostatectomy.
  European urology 2018 Leapman MS, Nguyen HG, Cowan JE, Xue L, Stohr B, Simko J, Cooperberg MR, Carroll PR
• STAG2 Is a Biomarker for Prediction of Recurrence and Progression in Papillary Non-Muscle-Invasive Bladder Cancer.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Lelo A, Prip F, Harris BT, Solomon D, Berry DL, Chaldekas K, Kumar A, Simko J, Jensen JB, Bhattacharyya P, Mannion C, Kim JS, Philips G, Dyrskjøt L, Waldman T
• The Diverse Genomic Landscape of Clinically Low-risk Prostate Cancer.
  European urology 2018 Cooperberg MR, Erho N, Chan JM, Feng FY, Fishbane N, Zhao SG, Simko JP, Cowan JE, Lehrer J, Alshalalfa M, Kolisnik T, Chelliserry J, Margrave J, Aranes M, Plessis MD, Buerki C, Tenggara I, Davicioni E…
• Polyoma virus-associated carcinomas of the urologic tract: a clinicopathologic and molecular study.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2018 Sirohi D, Vaske C, Sanborn Z, Smith SC, Don MD, Lindsey KG, Federman S, Vankalakunti M, Koo J, Bose S, Peralta-Venturina M, Ziffle JV, Grenert JP, Miller S, Chiu C, Amin MB, Simko JP, Stohr BA, …
• Management of Inverted Papilloma During Holmium Laser Enucleation of the Prostate.
  Urology 2018 Tzou DT, Cadwell C, Simko JP, Chi T, Stoller ML
• Renal NUT carcinoma: a case report.
  Histopathology 2017 Sirohi D, Garg K, Simko JP, Grenert JP
• Expression of the DNA repair gene MLH1 correlates with survival in patients who have resected pancreatic cancer and have received adjuvant chemoradiation: NRG Oncology RTOG Study 9704.
  Cancer 2017 Lawrence YR, Moughan J, Magliocco AM, Klimowicz AC, Regine WF, Mowat RB, DiPetrillo TA, Small W, Simko JP, Golan T, Winter KA, Guha C, Crane CH, Dicker AP
• Characterization and stratification of prostate lesions based on comprehensive multiparametric MRI using detailed whole-mount histopathology as a reference standard.
  NMR in biomedicine 2017 Starobinets O, Simko JP, Kuchinsky K, Kornak J, Carroll PR, Greene KL, Kurhanewicz J, Noworolski SM
• Pericytic tumors of the kidney-a clinicopathologic analysis of 17 cases.
  Human pathology 2017 Sirohi D, Smith SC, Epstein JI, Balzer BL, Simko JP, Balitzer D, Benhamida J, Kryvenko ON, Gupta NS, Paluru S, da Cunha IW, Leal DN, Williamson SR, de Peralta-Venturina M, Amin MB
• Application of a Prognostic Gleason Grade Grouping System to Assess Distant Prostate Cancer Outcomes.
  European urology 2016 Leapman MS, Cowan JE, Simko J, Roberge G, Stohr BA, Carroll PR, Cooperberg MR
• Tissue Sources for Accurate Measurement of Germline DNA Genotypes in Prostate Cancer Patients Treated With Radical Prostatectomy.
  The Prostate 2016 Emami NC, Leong L, Wan E, Van Blarigan EL, Cooperberg MR, Tenggara I, Carroll PR, Chan JM, Witte JS, Simko JP
• Systemic GM-CSF Recruits Effector T Cells into the Tumor Microenvironment in Localized Prostate Cancer.
  Cancer immunology research 2016 Wei XX, Chan S, Kwek S, Lewis J, Dao V, Zhang L, Cooperberg MR, Ryan CJ, Lin AM, Friedlander TW, Rini B, Kane C, Simko JP, Carroll PR, Small EJ, Fong L
• 18F Fluorocholine Dynamic Time-of-Flight PET/MR Imaging in Patients with Newly Diagnosed Intermediate- to High-Risk Prostate Cancer: Initial Clinical-Pathologic Comparisons.
  Radiology 2016 Choi JY, Yang J, Noworolski SM, Behr S, Chang AJ, Simko JP, Nguyen HG, Carroll PR, Kurhanewicz J, Seo Y
• Beyond Prostate Adenocarcinoma: Expanding the Differential Diagnosis in Prostate Pathologic Conditions.
  Radiographics : a review publication of the Radiological Society of North America, Inc 2016 Li Y, Mongan J, Behr SC, Sud S, Coakley FV, Simko J, Westphalen AC
• Application of a Clinical Whole-Transcriptome Assay for Staging and Prognosis of Prostate Cancer Diagnosed in Needle Core Biopsy Specimens.
  The Journal of molecular diagnostics : JMD 2016 Knudsen BS, Kim HL, Erho N, Shin H, Alshalalfa M, Lam LLC, Tenggara I, Chadwich K, Van Der Kwast T, Fleshner N, Davicioni E, Carroll PR, Cooperberg MR, Chan JM, Simko JP
• Prostate cancer with a pseudocapsule at MR imaging: a marker of high grade and stage disease?
  Clinical imaging 2016 Bonde AA, Korngold EK, Foster BR, Westphalen AC, Pettersson DR, Troxell ML, Simko JP, Coakley FV
• Patient-specific Meta-analysis of 2 Clinical Validation Studies to Predict Pathologic Outcomes in Prostate Cancer Using the 17-Gene Genomic Prostate Score.
  Urology 2015 Brand TC, Zhang N, Crager MR, Maddala T, Dee A, Sesterhenn IA, Simko JP, Cooperberg MR, Srivastava S, Rosner IL, Chan JM, Febbo PG, Carroll PR, Cullen J, Lawrence HJ
• Associations between circulating carotenoids, genomic instability and the risk of high-grade prostate cancer.
  The Prostate 2015 Nordström T, Van Blarigan EL, Ngo V, Roy R, Weinberg V, Song X, Simko J, Carroll PR, Chan JM, Paris PL
• Outcomes of Active Surveillance for Clinically Localized Prostate Cancer in the Prospective, Multi-Institutional Canary PASS Cohort.
  The Journal of urology 2015 Newcomb LF, Thompson IM, Boyer HD, Brooks JD, Carroll PR, Cooperberg MR, Dash A, Ellis WJ, Fazli L, Feng Z, Gleave ME, Kunju P, Lance RS, McKenney JK, Meng MV, Nicolas MM, Sanda MG, Simko J, So A, …
• Patterns of Local Failure following Radiation Therapy for Prostate Cancer.
  The Journal of urology 2015 Jalloh M, Leapman MS, Cowan JE, Shinohara K, Greene KL, Roach M, Chang AJ, Chan JM, Simko JP, Carroll PR
• Bladder wall recurrence of prostate cancer after high-dose-rate brachytherapy.
  Brachytherapy 2014 Raleigh DR, Hsu IC, Braunstein S, Chang AJ, Simko JP, Roach M
• A patient with cholangiocarcinoma demonstrating pathologic complete response to chemotherapy: exploring the role of neoadjuvant therapy in biliary tract cancer.
  Journal of gastrointestinal oncology 2014 Walker EJ, Simko JP, Nakakura EK, Ko AH
• Extended followup and risk factors for disease reclassification in a large active surveillance cohort for localized prostate cancer.
  The Journal of urology 2014 Welty CJ, Cowan JE, Nguyen H, Shinohara K, Perez N, Greene KL, Chan JM, Meng MV, Simko JP, Cooperberg MR, Carroll PR
• Hepatitis B viral reactivation secondary to imatinib treatment in a patient with gastrointestinal stromal tumor.
  Anticancer research 2014 Walker EJ, Simko JP, Ko AH
• A 17-gene assay to predict prostate cancer aggressiveness in the context of Gleason grade heterogeneity, tumor multifocality, and biopsy undersampling.
  European urology 2014 Klein EA, Cooperberg MR, Magi-Galluzzi C, Simko JP, Falzarano SM, Maddala T, Chan JM, Li J, Cowan JE, Tsiatis AC, Cherbavaz DB, Pelham RJ, Tenggara-Hunter I, Baehner FL, Knezevic D, Febbo PG, Shak S, …
• Role of endorectal MR imaging and MR spectroscopic imaging in defining treatable intraprostatic tumor foci in prostate cancer: quantitative analysis of imaging contour compared to whole-mount histopathology.
  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2014 Anwar M, Westphalen AC, Jung AJ, Noworolski SM, Simko JP, Kurhanewicz J, Roach M, Carroll PR, Coakley FV
• Pulmonary coccidiomycosis masquerading as refractory metastatic Ewing sarcoma.
  Journal of pediatric hematology/oncology 2014 Stieglitz E, Hsiang MS, Simko JP, Hirose S, Goldsby RE
• Clinical utility of endorectal MRI-guided prostate biopsy: preliminary experience.
  Journal of magnetic resonance imaging : JMRI 2013 Jung AJ, Westphalen AC, Kurhanewicz J, Wang ZJ, Carroll PR, Simko JP, Coakley FV
• Semiautomatic registration of digital histopathology images to in vivo MR images in molded and unmolded prostates.
  Journal of magnetic resonance imaging : JMRI 2013 Starobinets O, Guo R, Simko JP, Kuchinsky K, Kurhanewicz J, Carroll PR, Greene KL, Noworolski SM
• Editorial comment.
  The Journal of urology 2013 Simko JP
• Benign prostate glandular tissue at radical prostatectomy surgical margins.
  Urology 2013 Odisho AY, Washington SL, Meng MV, Cowan JE, Simko JP, Carroll PR
• Validation of a cell-cycle progression gene panel to improve risk stratification in a contemporary prostatectomy cohort.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013 Cooperberg MR, Simko JP, Cowan JE, Reid JE, Djalilvand A, Bhatnagar S, Gutin A, Lanchbury JS, Swanson GP, Stone S, Carroll PR
• Do adenocarcinomas of the prostate with Gleason score (GS) ≤6 have the potential to metastasize to lymph nodes?
  The American journal of surgical pathology 2012 Ross HM, Kryvenko ON, Cowan JE, Simko JP, Wheeler TM, Epstein JI
• Measurements of T(1) -relaxation in ex vivo prostate tissue at 132 μT.
  Magnetic resonance in medicine 2012 Busch S, Hatridge M, Mößle M, Myers W, Wong T, Mück M, Chew K, Kuchinsky K, Simko J, Clarke J
• Inhibition of Granzyme B by PI-9 protects prostate cancer cells from apoptosis.
  The Prostate 2011 Ray M, Hostetter DR, Loeb CR, Simko J, Craik CS
• Metastatic melanoma with striking adenocarcinomatous differentiation illustrating phenotypic plasticity in melanoma.
  The American journal of surgical pathology 2011 Jalas JR, Vemula S, Bezrookove V, Leboit PE, Simko JP, Bastian BC
• Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients.
  Cancer research 2010 Moltzahn F, Olshen AB, Baehner L, Peek A, Fong L, Stöppler H, Simko J, Hilton JF, Carroll P, Blelloch R
• Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer.
  Cancer causes & control : CCC 2010 Chan JM, Weinberg V, Magbanua MJ, Sosa E, Simko J, Shinohara K, Federman S, Mattie M, Hughes-Fulford M, Haqq C, Carroll PR
• Metabolic, pathologic, and genetic analysis of prostate tissues: quantitative evaluation of histopathologic and mRNA integrity after HR-MAS spectroscopy.
  NMR in biomedicine 2009 Santos CF, Kurhanewicz J, Tabatabai ZL, Simko JP, Keshari KR, Gbegnon A, Santos RD, Federman S, Shinohara K, Carroll PR, Haqq CM, Swanson MG
• A group of genome-based biomarkers that add to a Kattan nomogram for predicting progression in men with high-risk prostate cancer.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Paris PL, Weinberg V, Albo G, Roy R, Burke C, Simko J, Carroll P, Collins C
• Mucinous adenocarcinoma of the prostate: MRI and MR spectroscopy features.
  AJR. American journal of roentgenology 2009 Westphalen AC, Coakley FV, Kurhanewicz J, Reed G, Wang ZJ, Simko JP
• Functional phenotyping and genotyping of circulating tumor cells from patients with castration resistant prostate cancer.
  Cancer letters 2009 Paris PL, Kobayashi Y, Zhao Q, Zeng W, Sridharan S, Fan T, Adler HL, Yera ER, Zarrabi MH, Zucker S, Simko J, Chen WT, Rosenberg J
• Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR-MAS spectroscopy of biopsy tissues.
  Magnetic resonance in medicine 2008 Tessem MB, Swanson MG, Keshari KR, Albers MJ, Joun D, Tabatabai ZL, Simko JP, Shinohara K, Nelson SJ, Vigneron DB, Gribbestad IS, Kurhanewicz J
• Quantification of choline- and ethanolamine-containing metabolites in human prostate tissues using 1H HR-MAS total correlation spectroscopy.
  Magnetic resonance in medicine 2008 Swanson MG, Keshari KR, Tabatabai ZL, Simko JP, Shinohara K, Carroll PR, Zektzer AS, Kurhanewicz J
• Peripheral zone prostate cancer: accuracy of different interpretative approaches with MR and MR spectroscopic imaging.
  Radiology 2007 Westphalen AC, Coakley FV, Qayyum A, Swanson M, Simko JP, Lu Y, Zhao S, Carroll PR, Yeh BM, Kurhanewicz J
• High-grade prostatic intraepithelial neoplasia in patients with prostate cancer: MR and MR spectroscopic imaging features--initial experience.
  Radiology 2006 Hom JJ, Coakley FV, Simko JP, Lu Y, Qayyum A, Westphalen AC, Schmitt LD, Carroll PR, Kurhanewicz J
• Quantitative analysis of prostate metabolites using 1H HR-MAS spectroscopy.
  Magnetic resonance in medicine 2006 Swanson MG, Zektzer AS, Tabatabai ZL, Simko J, Jarso S, Keshari KR, Schmitt L, Carroll PR, Shinohara K, Vigneron DB, Kurhanewicz J
• Prostate cancer: endorectal MR imaging and MR spectroscopic imaging--distinction of true-positive results from chance-detected lesions.
  Radiology 2006 Hom JJ, Coakley FV, Simko JP, Qayyum A, Lu Y, Schmitt L, Carroll PR, Kurhanewicz J
• Molecular analysis of WFDC1/ps20 gene in prostate cancer.
  The Prostate 2004 Watson JE, Kamkar S, James K, Kowbel D, Andaya A, Paris PL, Simko J, Carroll P, McAlhany S, Rowley D, Collins C
• Integration of high-resolution array comparative genomic hybridization analysis of chromosome 16q with expression array data refines common regions of loss at 16q23-qter and identifies underlying candidate tumor suppressor genes in prostate cancer.
  Oncogene 2004 Watson JE, Doggett NA, Albertson DG, Andaya A, Chinnaiyan A, van Dekken H, Ginzinger D, Haqq C, James K, Kamkar S, Kowbel D, Pinkel D, Schmitt L, Simko JP, Volik S, Weinberg VK, Paris PL, Collins C
• Differences in laboratory findings for cerebrospinal fluid specimens obtained from patients with meningitis or encephalitis due to herpes simplex virus (HSV) documented by detection of HSV DNA.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2002 Simko JP, Caliendo AM, Hogle K, Versalovic J