Jeannette Tenthorey, PhD
Assistant Professor
Cellular Molecular Pharmacology
School of Medicine

Dr. Tenthorey's lab focuses on understanding how germline-encoded innate immune receptors are built to successfully detect rapidly evolving viral pathogens. Through evolutionary, biochemical and structural dissection, the lab uncovers basic design principles as well as molecular understanding of host-pathogen interactions.

Awards

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• DP2 New Innovator Award, NIH NIAID, 2024-2029
• Mathilde Krim Fellowship, American Foundation for AIDS Research, 2022-2023
• Andy Kaplan Prize, Cold Spring Harbor Retroviruses, 2022
• Intersections Science Fellow, 2021
• Leading Edge Fellow, 2021
• Hanna Gray Fellowship, Howard Hughes Medical Institute, 2018-2026
• Ray Owen Young Investigator Award, Midwinter Conference of Immunologists, 2017
• Outstanding Graduate Student Instructor Award, University of California, Berkeley, 2014
• National Science Foundation Graduate Research Fellowship, National Science Foundation, 2012-2015
• Berkeley Fellowship for Graduate Study, University of California, Berkeley, 2011

Education & Training

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• PhD Molecular and Cell Biology University of California, Berkeley 05/2017
• BA Biology Reed College 05/2009

Interests

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• Evolution
• Innate immunity
• HIV/AIDS

Websites

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• Tenthorey Lab (tenthoreylab.ucsf.edu)

Publications (15)

Top publication keywords:
MutationNLR Family, Pyrin Domain-Containing 3 ProteinNeuronal Apoptosis-Inhibitory ProteinTripartite Motif ProteinsVirus DiseasesHost-Pathogen InteractionsVirusesApoptosis Regulatory ProteinsCalcium-Binding ProteinsInflammasomesCatarrhiniUbiquitin-Protein LigasesSalmonella Infections, AnimalFlagellinMelanoma

• Evolutionary Landscapes of Host-Virus Arms Races.
  Annual review of immunology 2022 Tenthorey JL, Emerman M, Malik HS
• Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races.
  eLife 2020 Tenthorey JL, Young C, Sodeinde A, Emerman M, Malik HS
• Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes.
  Molecular cell 2014 Tenthorey JL, Kofoed EM, Daugherty MD, Malik HS, Vance RE
• Heterozygous and generalist MxA super-restrictors overcome breadth-specificity tradeoffs in antiviral restriction.
  bioRxiv : the preprint server for biology 2024 Geiger RA, Khera D, Tenthorey JL, Kochs G, Graf L, Emerman M, Malik HS
• Antiviral Mx proteins have an ancient origin and widespread distribution among eukaryotes.
  bioRxiv : the preprint server for biology 2024 Langley CA, Dietzen PA, Emerman M, Tenthorey JL, Malik HS

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• Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations.
  bioRxiv : the preprint server for biology 2024 Tenthorey JL, Del Banco S, Ramzan I, Klingenberg H, Liu C, Emerman M, Malik HS
• Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Duxbury Z, Wang S, MacKenzie CI, Tenthorey JL, Zhang X, Huh SU, Hu L, Hill L, Ngou PM, Ding P, Chen J, Ma Y, Guo H, Castel B, Moschou PN, Bernoux M, Dodds PN, Vance RE, Jones JDG
• NLRC4 inflammasome activation is NLRP3- and phosphorylation-independent during infection and does not protect from melanoma.
  The Journal of experimental medicine 2020 Tenthorey JL, Chavez RA, Thompson TW, Deets KA, Vance RE, Rauch I
• Cryo-EM studies of NAIP-NLRC4 inflammasomes.
  Methods in enzymology 2019 Haloupek N, Grob P, Tenthorey J, Vance RE, Nogales E
• The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion.
  Science (New York, N.Y.) 2017 Tenthorey JL, Haloupek N, López-Blanco JR, Grob P, Adamson E, Hartenian E, Lind NA, Bourgeois NM, Chacón P, Nogales E, Vance RE
• NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8.
  Immunity 2017 Rauch I, Deets KA, Ji DX, von Moltke J, Tenthorey JL, Lee AY, Philip NH, Ayres JS, Brodsky IE, Gronert K, Vance RE
• NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo.
  The Journal of experimental medicine 2016 Rauch I, Tenthorey JL, Nichols RD, Al Moussawi K, Kang JJ, Kang C, Kazmierczak BI, Vance RE
• An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition.
  The Journal of biological chemistry 2015 Girard JR, Tenthorey JL, Morgan DO
• RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.
  Nature immunology 2009 Hewitt SL, Yin B, Ji Y, Chaumeil J, Marszalek K, Tenthorey J, Salvagiotto G, Steinel N, Ramsey LB, Ghysdael J, Farrar MA, Sleckman BP, Schatz DG, Busslinger M, Bassing CH, Skok JA
• Diagnostic markers for early detection of ovarian cancer.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Visintin I, Feng Z, Longton G, Ward DC, Alvero AB, Lai Y, Tenthorey J, Leiser A, Flores-Saaib R, Yu H, Azori M, Rutherford T, Schwartz PE, Mor G