Jeanette McCarthy, MPH, PhD
Associate Professor
Medicine
School of Medicine

I believe informed consumers will play a major role in their health care going forward.In 2014, I helped launch the first consumer-facing magazine in this field, Genome (genomemag.com), where I was founding Editor-in-Chief. Health care providers also require education that is accessible and practical. I have developed courses in precision medicine at UC Berkeley Extension and through UCSF via Coursera (www.coursera.org/course/genomicmedicine). I also design and delivers workshops, symposia and webinars on more general as well as technical topics related to precision medicine through my consulting business, Precision Medicine Advisors (precisionmedicineadvisors.com) and the Precision Medicine Academy (precisionmedicineacademy.org).

• A note from the editors.
  Personalized medicine 2018 Ginsburg GS, McCarthy JJ, Patrinos GP
• Toward clinical genomics in everyday medicine: perspectives and recommendations.
  Expert review of molecular diagnostics 2016 Delaney SK, Hultner ML, Jacob HJ, Ledbetter DH, McCarthy JJ, Ball M, Beckman KB, Belmont JW, Bloss CS, Christman MF, Cosgrove A, Damiani SA, Danis T, Delledonne M, Dougherty MJ, Dudley JT, Faucett WA,…
• Clinical application of pharmacogenetics: focusing on practical issues.
  Pharmacogenomics 2015 Chang MT, McCarthy JJ, Shin J
• Driving personalized medicine forward: the who, what, when, and how of educating the health-care workforce.
  Molecular genetics & genomic medicine 2014 McCarthy JJ
• Genomic medicine: a decade of successes, challenges, and opportunities.
  Science translational medicine 2013 McCarthy JJ, McLeod HL, Ginsburg GS
• Development and evaluation of a genetic risk score for obesity.
  Biodemography and social biology 2013 Belsky DW, Moffitt TE, Sugden K, Williams B, Houts R, McCarthy J, Caspi A
• Pleiotropy and allelic heterogeneity in the TOMM40-APOE genomic region related to clinical and metabolic features of hepatitis C infection.
  Human genetics 2012 Chiba-Falek O, Linnertz C, Guyton J, Gardner SD, Roses AD, McCarthy JJ, Patel K
• Metaprotein expression modeling for label-free quantitative proteomics.
  BMC bioinformatics 2012 Lucas JE, Thompson JW, Dubois LG, McCarthy J, Tillmann H, Thompson A, Shire N, Hendrickson R, Dieguez F, Goldman P, Schwarz K, Patel K, McHutchison J, Moseley MA
• Reply to: “Interaction between IL28B and PNPLA3 genotypes in the pathogenesis of steatosis in chronic hepatitis C non genotype-3 patients”.
  Journal of Hepatology 2012 Eric Trépo, Pierre Pradat, Jeanette J. McCarthy, Hans L. Tillmann
• Reply to: “Favorable association between genetic polymorphisms near the IL28B gene and hepatic steatosis: Direct or indirect?”.
  Journal of Hepatology 2012 Hans Ludger Tillmann, Jeanette J. McCarthy
• Characterization of the poly-T variant in the TOMM40 gene in diverse populations.
  PloS one 2012 Linnertz C, Saunders AM, Lutz MW, Crenshaw DM, Grossman I, Burns DK, Whitfield KE, Hauser MA, McCarthy JJ, Ulmer M, Allingham R, Welsh-Bohmer KA, Roses AD, Chiba-Falek O
• Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels.
  Thrombosis and haemostasis 2011 Corsetti JP, Ryan D, Moss AJ, McCarthy J, Goldenberg I, Zareba W, Sparks CE
• Characterization of serum proteins associated with IL28B genotype among patients with chronic hepatitis C.
  PloS one 2011 Cyr DD, Lucas JE, Thompson JW, Patel K, Clark PJ, Thompson A, Tillmann HL, McHutchison JG, Moseley MA, McCarthy JJ
• High predictive accuracy of an unbiased proteomic profile for sustained virologic response in chronic hepatitis C patients.
  Hepatology (Baltimore, Md.) 2011 Patel K, Lucas JE, Thompson JW, Dubois LG, Tillmann HL, Thompson AJ, Uzarski D, Califf RM, Moseley MA, Ginsburg GS, McHutchison JG, McCarthy JJ, MURDOCK Horizon 1 Study Team
• Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C.
  Journal of hepatology 2011 Tillmann HL, Patel K, Muir AJ, Guy CD, Li JH, Lao XQ, Thompson A, Clark PJ, Gardner SD, McHutchison JG, McCarthy JJ
• 1345 INTERACTION BETWEEN IL28B CCR5?32, AND HCV PERSISTENCE WITH GBV-C VIREMIA AND SYMPTOMS DURING ACUTE INFECTION.
  Journal of Hepatology 2011 S. Tenckhoff, J. Wiegand, K. Patel, M. Wiese, H. Tenckhoff, H.D. Nischalke, U. Kullig, U. Gobel, E. Capka, I. Schiefte, W. Güthoff, K. Grüngreiff, I. König, U. Spengler, J.J. McCarthy, A.J. Thompson, …
• Gene by sex interaction for measures of obesity in the framingham heart study.
  Journal of obesity 2010 Benjamin AM, Suchindran S, Pearce K, Rowell J, Lien LF, Guyton JR, McCarthy JJ
• The Alzheimer's associated 5' region of the SORL1 gene cis regulates SORL1 transcripts expression.
  Neurobiology of aging 2010 McCarthy JJ, Saith S, Linnertz C, Burke JR, Hulette CM, Welsh-Bohmer KA, Chiba-Falek O
• The effect of SNCA 3' region on the levels of SNCA-112 splicing variant.
  Neurogenetics 2010 McCarthy JJ, Linnertz C, Saucier L, Burke JR, Hulette CM, Welsh-Bohmer KA, Chiba-Falek O
• A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice.
  Gastroenterology 2010 Tillmann HL, Thompson AJ, Patel K, Wiese M, Tenckhoff H, Nischalke HD, Lokhnygina Y, Kullig U, Göbel U, Capka E, Wiegand J, Schiefke I, Güthoff W, Grüngreiff K, König I, Spengler U, McCarthy J, …
• Hepatitis C trials that combine investigational agents with pegylated interferon should be stratified by interleukin-28B genotype.
  Hepatology (Baltimore, Md.) 2010 Thompson AJ, Muir AJ, Sulkowski MS, Patel K, Tillmann HL, Clark PJ, Naggie S, Fellay J, Ge D, McCarthy JJ, Goldstein DB, McHutchison JG
• Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection.
  Hepatology (Baltimore, Md.) 2010 Li JH, Lao XQ, Tillmann HL, Rowell J, Patel K, Thompson A, Suchindran S, Muir AJ, Guyton JR, Gardner SD, McHutchison JG, McCarthy JJ
• Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.
  PLoS genetics 2010 Suchindran S, Rivedal D, Guyton JR, Milledge T, Gao X, Benjamin A, Rowell J, Ginsburg GS, McCarthy JJ
• 125 IL28B POLYMORPHISM IS ASSOCIATED WITH JAUNDICE DURING ACUTE HCV INFECTION AND IS A STRONG PREDICTOR FOR SPONTANEOUS CLEARANCE IN THE PROSPECTIVE GERMAN ANTI-D COHORT.
  Journal of Hepatology 2010 H. Tillmann, A.J. Thompson, K. Patel, M. Wiese, H. Tenckhoff, H.D. Nischalke, U. Kullig, U. Goebel, E. Capka, J. Wiegand, I. Schiefke, U. Spengler, J. McCarthy, K. Shianna, D.B. Goldstein, J.G. …
• Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin.
  Gastroenterology 2010 McCarthy JJ, Li JH, Thompson A, Suchindran S, Lao XQ, Patel K, Tillmann HL, Muir AJ, McHutchison JG
• Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study.
  BMC medical genetics 2010 Chiba-Falek O, Nichols M, Suchindran S, Guyton J, Ginsburg GS, Barrett-Connor E, McCarthy JJ
• Racial differences in the interaction between family history and risk factors associated with diabetes in the National Health and Nutritional Examination Survey, 1999-2004.
  Genetics in medicine : official journal of the American College of Medical Genetics 2009 Suchindran S, Vana AM, Shaffer RA, Alcaraz JE, McCarthy JJ
• Polymorphisms of the scavenger receptor class B member 1 are associated with insulin resistance with evidence of gene by sex interaction.
  The Journal of clinical endocrinology and metabolism 2009 McCarthy JJ, Somji A, Weiss LA, Steffy B, Vega R, Barrett-Connor E, Talavera G, Glynne R
• Transforming the practice of medicine using genomics.
  Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases 2009 Ginsburg GS, Ginsburg GS, J McCarthy J
• Validity of reported genetic risk factors for acute coronary syndrome.
  JAMA 2007 McCarthy JJ, Topol EJ
• Family History of Diabetes, Acculturation, and the Metabolic Syndrome among Mexican Americans: Proyecto SALSA.
  Metabolic syndrome and related disorders 2007 Nelson T, Perez A, Alcaraz J, Talavera G, McCarthy JJ
• Taking cardiovascular genetic association studies to the next level.
  Journal of the American College of Cardiology 2007 Ginsburg GS, Shah SH, McCarthy JJ
• Gene by sex interaction in the etiology of coronary heart disease and the preceding metabolic syndrome.
  Nutrition, metabolism, and cardiovascular diseases : NMCD 2006 McCarthy JJ
• Life, diversity and the pursuit of haplotypes.
  Nature biotechnology 2005 McCarthy J
• Atherosclerotic risk genotypes and recurrent coronary events after myocardial infarction.
  The American journal of cardiology 2005 Moss AJ, Ryan D, Oakes D, Goldstein RE, Greenberg H, Bodenheimer MM, Brown MW, Case RB, Dwyer EM, Eberly SW, Francis CW, Gillespie JA, Krone RJ, Lichstein E, MacCluer JW, Marcus FI, McCarthy J, Sparks…
• Aspirin resistance and a single gene.
  The American journal of cardiology 2005 Jefferson BK, Foster JH, McCarthy JJ, Ginsburg G, Parker A, Kottke-Marchant K, Topol EJ
• Modification of the effects of estrogen therapy on HDL cholesterol levels by polymorphisms of the HDL-C receptor, SR-BI: the Rancho Bernardo Study.
  Atherosclerosis 2005 Richard E, von Muhlen D, Barrett-Connor E, Alcaraz J, Davis R, McCarthy JJ
• Coronary artery disease and the thrombospondin single nucleotide polymorphisms.
  The international journal of biochemistry & cell biology 2004 Stenina OI, Byzova TV, Adams JC, McCarthy JJ, Topol EJ, Plow EF
• Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes.
  Journal of medical genetics 2004 McCarthy JJ, Parker A, Salem R, Moliterno DJ, Wang Q, Plow EF, Rao S, Shen G, Rogers WJ, Newby LK, Cannata R, Glatt K, Topol EJ, GeneQuest Investigators
• Replication of the association between the thrombospondin-4 A387P polymorphism and myocardial infarction.
  American heart journal 2004 Wessel J, Topol EJ, Ji M, Meyer J, McCarthy JJ
• 847-3 Aspirin resistance is associated with a single nucleotide polymorphism in the P2Y1 ADP receptor gene.
  Journal of the American College of Cardiology 2004 Brian K Jefferson, Jennifer H Foster, Jeanette J McCarthy, Kandice Kottke-Marchant, Eric J Topol
• Amino acid residue at position 13 in HLA-DR beta chain plays a critical role in the development of Kaposi's sarcoma in AIDS patients.
  AIDS (London, England) 2004 Gayà A, Esteve A, Casabona J, McCarthy JJ, Martorell J, Schulz TF, Whitby D, EURO-SHAKS working group
• Advances in pharmacogenomic research and development.
  Molecular biotechnology 2003 McCarthy JJ
• Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients.
  Human genetics 2003 McCarthy JJ, Meyer J, Moliterno DJ, Newby LK, Rogers WJ, Topol EJ, GenQuest multicenter study
• Association of genetic variants in the HDL receptor, SR-B1, with abnormal lipids in women with coronary artery disease.
  Journal of medical genetics 2003 McCarthy JJ, Lehner T, Reeves C, Moliterno DJ, Newby LK, Rogers WJ, Topol EJ, Genequest investigators
• Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations.
  Human heredity 2003 McCarthy JJ, Lewitzky S, Reeves C, Permutt A, Glaser B, Groop LC, Lehner T, Meyer JM
• Turning SNPs into Useful Markers of Drug Response.
  Pharmacogenomics 2002 Jeanette J. McCarthy
• Personalized medicine: revolutionizing drug discovery and patient care.
  Trends in biotechnology 2001 Ginsburg GS, McCarthy JJ
• Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction.
  Circulation 2001 Topol EJ, McCarthy J, Gabriel S, Moliterno DJ, Rogers WJ, Newby LK, Freedman M, Metivier J, Cannata R, O'Donnell CJ, Kottke-Marchant K, Murugesan G, Plow EF, Stenina O, Daley GQ
• The use of single-nucleotide polymorphism maps in pharmacogenomics.
  Nature biotechnology 2000 McCarthy JJ, Hilfiker R
• Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, and DPB1) loci in 26 human ethnic groups.
  Tissue antigens 1999 Chen JJ, Hollenbach JA, Trachtenberg EA, Just JJ, Carrington M, Rønningen KS, Begovich A, King MC, McWeeney S, Mack SJ, Erlich HA, Thomson G
• CCR5del32 in perinatal HIV-1 infection.
  Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1997 Rousseau CM, Just JJ, Abrams EJ, Casabona J, Stein Z, King MC
• Intercellular adhesion molecule-1 deficiency prolongs survival and protects against the development of pulmonary inflammation during murine lupus.
  The Journal of clinical investigation 1997 Lloyd CM, Gonzalo JA, Salant DJ, Just J, Gutierrez-Ramos JC
• African-American HLA class II allele and haplotype diversity.
  Tissue antigens 1997 Just JJ, King MC, Thomson G, Klitz W
• Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk.
  Cancer research 1997 Stanford JL, Just JJ, Gibbs M, Wicklund KG, Neal CL, Blumenstein BA, Ostrander EA
• African-American HLA class II allele and haplotype diversity.
  Tissue antigens 1996 Just JJ, King MC, Thomson G, Klitz W
• MHC class II alleles associated with clinical and immunological manifestations of HIV-1 infection among children in Catalonia, Spain.
  Tissue antigens 1996 Just JJ, Casabona J, Bertrán J, Montané C, Fortuny C, Rodrigo C, Mur A, Bosque M, Jovane L, King MC
• The role of host genetics in the natural history of HIV-1 infection: the needles in the haystack.
  AIDS (London, England) 1996 Keet IP, Klein MR, Just JJ, Kaslow RA
• Genetic predisposition to HIV-1 infection and acquired immune deficiency virus syndrome: a review of the literature examining associations with HLA [corrected].
  Human immunology 1995 Just JJ
• Influence of host genotype on progression to acquired immunodeficiency syndrome among children infected with human immunodeficiency virus type 1.
  The Journal of pediatrics 1995 Just JJ, Abrams E, Louie LG, Urbano R, Wara D, Nicholas SW, Stein Z, King MC
• Genetic variation among the Mapuche Indians from the Patagonian region of Argentina: mitochondrial DNA sequence variation and allele frequencies of several nuclear genes.
  EXS 1993 Ginther C, Corach D, Penacino GA, Rey JA, Carnese FR, Hutz MH, Anderson A, Just J, Salzano FM, King MC
• Genetic risk factors for perinatally acquired HIV-1 infection.
  Paediatric and perinatal epidemiology 1992 Just J, Louie L, Abrams E, Nicholas SW, Wara D, Stein Z, King MC