Jean Nakamura, MD
Professor
Radiation Oncology
School of Medicine
Awards
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- UCSF Chancellor's Fund Learning and Development Grant, UCSF, 2020
- Teaching Award, American College of Radiolgoy, 2013
- St. Baldrick's Foundation Scholar Award, 2012-2015
Education & Training
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- Postdoctoral Fellowship University of California, San Francisco 06/2005
- Residency Radiation Oncology University of California, San Francisco 06/2003
- Internship, Internal Medicine Internal Medicine University of Chicago 06/1999
- M.D. Pritzker School of Medicine University of Chicago 1998
- A.B. Biological Sciences University of Chicago 10/1/13
Websites
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- Acoustic4acure (acoustic4acure.com)
- DHART SPORE (dhartspore.org)
- Nakamura Lab website (nakamuralab.ucsf.edu)
- Clinical Profile at UCSF Medical Center (ucsfhealth.org)
- Clinical Profile at UCSF Benioff Children's Hospital (ucsfbenioffchildrens.org)
Grants and Projects
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- Developmental and HyperActive Ras Tumor SPORE, NIH, 2015-2026
- Mitigating long-term treatment-related morbidity in Childhood Cancer Survivors, NIH/NCI, 2019-2026
- Investigating the role of ApoE4 and amyloid beta in susceptibility to neurologic complications after brain radiotherapy, NIH, 2021-2023
- Utilizing animal models to investigate therapy-induced malignancies, , 2019-2022
- Metabolic vulnerabilities of NF1 mutant tumors, Department of Defense, 2018-2020
- The role of mTOR in Ras mediated gliomagenesis, NIH, 2005-2011
Publications (59)
Top publication keywords:
Radiation, IonizingNeurofibromin 1Space FlightDNA GlycosylasesGerm-Line MutationGlycolysisRadiosurgeryNeurofibromatosis 1Radiation InjuriesGenes, Neurofibromatosis 1Neoplasms, Radiation-InducedRadiation ExposureLoss of HeterozygosityBrain NeoplasmsNeoplasms, Second Primary
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Adverse radiation effect versus tumor progression following stereotactic radiosurgery for brain metastases: Implications of radiologic uncertainty.
Journal of neuro-oncology 2024 Salans M, Ni L, Morin O, Ziemer B, Capaldi DPI, Raleigh DR, Vasudevan HN, Chew J, Nakamura J, Sneed PK, Boreta L, Villanueva-Meyer JE, Theodosopoulos P, Braunstein S -
Molecular Features of Resected Melanoma Brain Metastases, Clinical Outcomes, and Responses to Immunotherapy.
JAMA network open 2023 Vasudevan HN, Delley C, Chen WC, Mirchia K, Pan S, Shukla P, Aabedi AA, Nguyen MP, Morshed RA, Young JS, Boreta L, Fogh SE, Nakamura JL, Theodosopoulos PV, Phillips J, Hervey-Jumper SL, Daras M, Pike … -
Mutational Status and Clinical Outcomes Following Systemic Therapy with or without Focal Radiation for Resected Melanoma Brain Metastases.
World neurosurgery 2022 Vasudevan HN, Susko MS, Ma L, Nakamura JL, Raleigh DR, Boreta L, Fogh S, Theodosopoulos PV, McDermott MW, Tsai KK, Sneed PK, Braunstein SE -
Primary and metastatic tumors exhibit systems-level differences in dependence on mitochondrial respiratory function.
PLoS biology 2022 Bennett NK, Nakaoka HJ, Laurent D, Okimoto RA, Sei Y, Horvai AE, Bivona TG, Ten Hoeve J, Graeber TG, Nakamura K, Nakamura JL -
Considerations for carcinogenesis countermeasure development using mouse models.
Life sciences in space research 2022 Nakamura JL
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Adverse radiation effect and freedom from progression following repeat stereotactic radiosurgery for brain metastases.
Journal of neurosurgery 2022 Sneed PK, Chan JW, Ma L, Braunstein SE, Theodosopoulos PV, Fogh SE, Nakamura JL, Boreta L, Raleigh DR, Ziemer BP, Morin O, Hervey-Jumper SL, McDermott MW -
Resection with intraoperative cesium-131 brachytherapy as salvage therapy for recurrent brain tumors.
Journal of neurosurgery 2022 Chen WC, Lafreniere M, Phuong C, Liu SJ, Baal JD, Lometti M, Morin O, Ziemer B, Vasudevan HN, Lucas CG, Hervey-Jumper SL, Theodosopoulos PV, Magill ST, Fogh S, Nakamura JL, Boreta L, Sneed PK, … -
Letter: Patterns of Intermediate- and High-Risk Meningioma Recurrence After Treatment With Postoperative External Beam Radiotherapy.
Neurosurgery 2021 Susko MS, Chen WC, Vasudevan HN, Magill ST, Lucas CG, Oberheim Bush NA, Solomon DA, Theodosopoulos PV, McDermott MW, Villanueva-Meyer JE, Boreta L, Nakamura JL, Sneed PK, Braunstein SE, Raleigh DR -
Irradiation of Nf1 mutant mouse models of spinal plexiform neurofibromas drives pathologic progression and decreases survival.
Neuro-oncology advances 2021 Laurent D, Smith AE, Bessler WK, Mendonca M, Chin-Sinex H, Descovich M, Horvai AE, Clapp DW, Nakamura JL -
Differentiating Radiation Necrosis from Brain Tumor Using Hyperpolarized Carbon-13 MR Metabolic Imaging.
Molecular imaging and biology 2021 Park I, Kim S, Pucciarelli D, Song J, Choi JM, Lee KH, Kim YH, Jung S, Yoon W, Nakamura JL -
Redistributing Central Target Dose Hot Spots for Hypofractionated Radiosurgery of Large Brain Tumors: A Proof-of-Principle Study.
Acta neurochirurgica. Supplement 2021 Ma L, Braunstein SE, Golden E, Fogh S, Nakamura J, McDermott MW, Sneed PK -
A Prognostic Gene-Expression Signature and Risk Score for Meningioma Recurrence After Resection.
Neurosurgery 2020 Chen WC, Vasudevan HN, Choudhury A, Pekmezci M, Lucas CG, Phillips J, Magill ST, Susko MS, Braunstein SE, Oberheim Bush NA, Boreta L, Nakamura JL, Villanueva-Meyer JE, Sneed PK, Perry A, McDermott MW,… -
Germline MUTYH Mutation in a Pediatric Cancer Survivor Developing a Secondary Malignancy.
Journal of pediatric hematology/oncology 2020 Lavergne V, Sabnis A, Tupule A, Davidson PR, Kline C, Matthay K, Nicolaides T, Goldsby R, Braunstein S, Fogh SE, Sneed PK, Menzel P, Nakamura A, DuBois SG, Haas-Kogan DA, Nakamura JL -
Defining the ATPome reveals cross-optimization of metabolic pathways.
Nature communications 2020 Bennett NK, Nguyen MK, Darch MA, Nakaoka HJ, Cousineau D, Ten Hoeve J, Graeber TG, Schuelke M, Maltepe E, Kampmann M, Mendelsohn BA, Nakamura JL, Nakamura K -
Nf1-Mutant Tumors Undergo Transcriptome and Kinome Remodeling after Inhibition of either mTOR or MEK.
Molecular cancer therapeutics 2020 Pucciarelli D, Angus SP, Huang B, Zhang C, Nakaoka HJ, Krishnamurthi G, Bandyopadhyay S, Clapp DW, Shannon K, Johnson GL, Nakamura JL -
Neuro-Oncology Practice Clinical Debate: Early treatment or observation for patients with newly diagnosed oligodendroglioma and small-volume residual disease.
Neuro-oncology practice 2020 Fogh SE, Boreta L, Nakamura JL, Johnson DR, Chi AS, Kurz SC -
Stereotactic Radiosurgery to More Than 10 Brain Metastases: Evidence to Support the Role of Radiosurgery for Ideal Hippocampal Sparing in the Treatment of Multiple Brain Metastases.
World neurosurgery 2019 Susko MS, Garcia MA, Ma L, Nakamura JL, Raleigh DR, Fogh S, Theodosopoulos P, McDermott M, Sneed PK, Braunstein SE -
Subsequent Neoplasms After a Primary Tumor in Individuals With Neurofibromatosis Type 1.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2019 Bhatia S, Chen Y, Wong FL, Hageman L, Smith K, Korf B, Cannon A, Leidy DJ, Paz A, Andress JE, Friedman GK, Metrock K, Neglia JP, Arnold M, Turcotte LM, de Blank P, Leisenring W, Armstrong GT, Robison … -
Reirradiation of recurrent high-grade glioma and development of prognostic scores for progression and survival.
Neuro-oncology practice 2019 Chapman CH, Hara JH, Molinaro AM, Clarke JL, Oberheim Bush NA, Taylor JW, Butowski NA, Chang SM, Fogh SE, Sneed PK, Nakamura JL, Raleigh DR, Braunstein SE -
A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure.
PLoS biology 2018 Mendelsohn BA, Bennett NK, Darch MA, Yu K, Nguyen MK, Pucciarelli D, Nelson M, Horlbeck MA, Gilbert LA, Hyun W, Kampmann M, Nakamura JL, Nakamura K -
Brain metastasis growth on preradiosurgical magnetic resonance imaging.
Practical radiation oncology 2018 Garcia MA, Anwar M, Yu Y, Duriseti S, Merritt B, Nakamura J, Hess C, Theodosopoulos PV, McDermott M, Sneed PK, Braunstein SE -
Genomic characterization of chronic lymphocytic leukemia (CLL) in radiation-exposed Chornobyl cleanup workers.
Environmental health : a global access science source 2018 Ojha J, Dyagil I, Finch SC, Reiss RF, de Smith AJ, Gonseth S, Zhou M, Hansen HM, Sherborne AL, Nakamura J, Bracci PM, Gudzenko N, Hatch M, Babkina N, Little MP, Chumak VV, Walsh KM, Bazyka D, Wiemels … -
Mutational landscape of radiation-associated angiosarcoma of the breast.
Oncotarget 2018 Thibodeau BJ, Lavergne V, Dekhne N, Benitez P, Amin M, Ahmed S, Nakamura JL, Davidson PR, Nakamura AO, Grills IS, Chen PY, Wobb J, Wilson GD -
A pooled mutational analysis identifies ionizing radiation-associated mutational signatures conserved between mouse and human malignancies.
Scientific reports 2017 Davidson PR, Sherborne AL, Taylor B, Nakamura AO, Nakamura JL -
Indications and Efficacy of Gamma Knife Stereotactic Radiosurgery for Recurrent Glioblastoma: 2 Decades of Institutional Experience.
Neurosurgery 2017 Imber BS, Kanungo I, Braunstein S, Barani IJ, Fogh SE, Nakamura JL, Berger MS, Chang EF, Molinaro AM, Cabrera JR, McDermott MW, Sneed PK, Aghi MK -
Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2016 Sherborne AL, Lavergne V, Yu K, Lee L, Davidson PR, Mazor T, Smirnoff IV, Horvai AE, Loh M, DuBois SG, Goldsby RE, Neglia JP, Hammond S, Robison LL, Wustrack R, Costello JF, Nakamura AO, Shannon KM, … -
Discovery of additional brain metastases on the day of stereotactic radiosurgery: risk factors and outcomes.
Journal of neurosurgery 2016 Garcia MA, Lazar A, Duriseti S, Raleigh DR, Hess CP, Fogh SE, Barani IJ, Nakamura JL, Larson DA, Theodosopoulos P, McDermott M, Sneed PK, Braunstein S -
Parameters influencing local control of meningiomas treated with radiosurgery.
Journal of neuro-oncology 2016 Kaprealian T, Raleigh DR, Sneed PK, Nabavizadeh N, Nakamura JL, McDermott MW -
Assessment of image quality and dose calculation accuracy on kV CBCT, MV CBCT, and MV CT images for urgent palliative radiotherapy treatments.
Journal of applied clinical medical physics 2016 Held M, Cremers F, Sneed PK, Braunstein S, Fogh SE, Nakamura J, Barani I, Perez-Andujar A, Pouliot J, Morin O -
Investigating the clinical advantages of a robotic linac equipped with a multileaf collimator in the treatment of brain and prostate cancer patients.
Journal of applied clinical medical physics 2015 McGuinness CM, Gottschalk AR, Lessard E, Nakamura JL, Pinnaduwage D, Pouliot J, Sims C, Descovich M -
Mutational Analysis of Ionizing Radiation Induced Neoplasms.
Cell reports 2015 Sherborne AL, Davidson PR, Yu K, Nakamura AO, Rashid M, Nakamura JL -
Correction: Monoallelic Loss of the Imprinted Gene Grb10 Promotes Tumor Formation in Irradiated Nf1+/- Mice.
PLoS genetics 2015 Mroue R, Huang B, Braunstein S, Firestone AJ, Nakamura JL -
Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice.
PLoS genetics 2015 Mroue R, Huang B, Braunstein S, Firestone AJ, Nakamura JL -
Adverse radiation effect after stereotactic radiosurgery for brain metastases: incidence, time course, and risk factors.
Journal of neurosurgery 2015 Sneed PK, Mendez J, Vemer-van den Hoek JG, Seymour ZA, Ma L, Molinaro AM, Fogh SE, Nakamura JL, McDermott MW -
Interval From Imaging to Treatment Delivery in the Radiation Surgery Age: How Long Is Too Long?
International journal of radiation oncology, biology, physics 2015 Seymour ZA, Fogh SE, Westcott SK, Braunstein S, Larson DA, Barani IJ, Nakamura J, Sneed PK -
Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma.
Molecular cancer therapeutics 2014 Li N, Maly DJ, Chanthery YH, Sirkis DW, Nakamura JL, Berger MS, James CD, Shokat KM, Weiss WA, Persson AI -
Impact of millimeter-level margins on peripheral normal brain sparing for gamma knife radiosurgery.
International journal of radiation oncology, biology, physics 2014 Ma L, Sahgal A, Larson DA, Pinnaduwage D, Fogh S, Barani I, Nakamura J, McDermott M, Sneed P -
Response of primary glioblastoma cells to therapy is patient specific and independent of cancer stem cell phenotype.
Neuro-oncology 2013 Fouse SD, Nakamura JL, James CD, Chang S, Costello JF -
Radiotherapy-induced malignancies: review of clinical features, pathobiology, and evolving approaches for mitigating risk.
Frontiers in oncology 2013 Braunstein S, Nakamura JL -
Individual beam sharpening improves composite dose fall-off near a target for non-isocentric cyberknife radiosurgery.
Technology in cancer research & treatment 2013 Wahl M, Hwang A, Nakamura J, Barani I, Fogh S, Sneed P, McDermott M, Sahgal A, Ma L -
High-precision volume-staged Gamma Knife surgery and equivalent hypofractionation dose schedules for treating large arteriovenous malformations.
Journal of neurosurgery 2012 Fogh S, Ma L, Gupta N, Sahgal A, Nakamura JL, Barani I, Sneed PK, McDermott M, Larson DA -
Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms.
Cancer research 2012 Choi G, Huang B, Pinarbasi E, Braunstein SE, Horvai AE, Kogan S, Bhatia S, Faddegon B, Nakamura JL -
A technique for achieving submillimeter accuracy of volume-staged stereotactic radiosurgery.
Journal of radiosurgery and SBRT 2012 Ma L, Fogh S, Gupta N, Hwang A, Pinnaduwage D, Nakamura J, Barani I, McDermott M, Sneed PK, Larson DA, Sahgal A -
Prognostic factors for survival in patients treated with stereotactic radiosurgery for recurrent brain metastases after prior whole brain radiotherapy.
International journal of radiation oncology, biology, physics 2011 Caballero JA, Sneed PK, Lamborn KR, Ma L, Denduluri S, Nakamura JL, Barani IJ, McDermott MW -
Shot sequencing based on biological equivalent dose considerations for multiple isocenter Gamma Knife radiosurgery.
Physics in medicine and biology 2011 Ma L, Lee L, Barani I, Hwang A, Fogh S, Nakamura J, McDermott M, Sneed P, Larson DA, Sahgal A -
Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice.
Cancer research 2011 Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K -
A dosimetric comparison between Gamma Knife and CyberKnife treatment plans for trigeminal neuralgia.
Journal of neurosurgery 2010 Descovich M, Sneed PK, Barbaro NM, McDermott MW, Chuang CF, Barani IJ, Nakamura JL, Lijun M -
Gamma Knife radiosurgery for brain metastases from primary breast cancer.
International journal of radiation oncology, biology, physics 2009 Kased N, Binder DK, McDermott MW, Nakamura JL, Huang K, Berger MS, Wara WM, Sneed PK -
Prognostic factors and grading systems for overall survival in patients treated with radiosurgery for brain metastases: variation by primary site.
Journal of neurosurgery 2008 Golden DW, Lamborn KR, McDermott MW, Kunwar S, Wara WM, Nakamura JL, Sneed PK -
S6K1 plays a key role in glial transformation.
Cancer research 2008 Nakamura JL, Garcia E, Pieper RO -
Glioma invasiveness responds variably to irradiation in a co-culture model.
International journal of radiation oncology, biology, physics 2007 Nakamura JL, Haas-Kogan DA, Pieper RO -
Gamma knife radiosurgery for brainstem metastases: the UCSF experience.
Journal of neuro-oncology 2007 Kased N, Huang K, Nakamura JL, Sahgal A, Larson DA, McDermott MW, Sneed PK -
The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications.
Expert opinion on therapeutic targets 2007 Nakamura JL -
mTOR-independent translational control of the extrinsic cell death pathway by RalA.
Molecular and cellular biology 2006 Panner A, Nakamura JL, Parsa AT, Rodriguez-Viciana P, Berger MS, Stokoe D, Pieper RO -
Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism.
International journal of radiation oncology, biology, physics 2005 Gottschalk AR, Doan A, Nakamura JL, Stokoe D, Haas-Kogan DA -
Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism.
International journal of radiation oncology, biology, physics 2005 Gottschalk AR, Doan A, Nakamura JL, Haas-Kogan DA, Stokoe D -
PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas.
Journal of neuro-oncology 2005 Nakamura JL, Karlsson A, Arvold ND, Gottschalk AR, Pieper RO, Stokoe D, Haas-Kogan DA -
Comparison of intensity-modulated radiosurgery with gamma knife radiosurgery for challenging skull base lesions.
International journal of radiation oncology, biology, physics 2003 Nakamura JL, Pirzkall A, Carol MP, Xia P, Smith V, Wara WM, Petti PL, Verhey LJ, Sneed PK -
Dose conformity of gamma knife radiosurgery and risk factors for complications.
International journal of radiation oncology, biology, physics 2001 Nakamura JL, Verhey LJ, Smith V, Petti PL, Lamborn KR, Larson DA, Wara WM, McDermott MW, Sneed PK