Jean-Philippe Coppé, PhD
Associate Professor
Radiation Oncology
School of Medicine

Grants and Projects

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• Kinome-guided Targeting of Cooperative Dependencies in BRAF and KRAS Mutated Colorectal Cancer, NIH, 2019-2024

Publications (34)

Top publication keywords:
FibroblastsCyclin-Dependent Kinase Inhibitor p16HMGB1 ProteinTumor Suppressor Protein p53Tumor EscapeDrug Resistance, NeoplasmProto-Oncogene Proteins c-pim-1Paracrine CommunicationDNA DamageEpithelial CellsProtein Kinase C-alphaProto-Oncogene Proteins B-raf3-Phosphoinositide-Dependent Protein KinasesColorectal NeoplasmsCellular Senescence

• A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors.
  Nature cancer 2023 Ruiz-Saenz A, Atreya CE, Wang C, Pan B, Dreyer CA, Brunen D, Prahallad A, Muñoz DP, Ramms DJ, Burghi V, Spassov DS, Fewings E, Hwang YC, Cowdrey C, Moelders C, Schwarzer C, Wolf DM, Hann B, VandenBerg…
• Response and resistance to BRAFV600E inhibition in gliomas: Roadblocks ahead?
  Frontiers in oncology 2023 Capogiri M, De Micheli AJ, Lassaletta A, Muñoz DP, Coppé JP, Mueller S, Guerreiro Stucklin AS
• Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies.
  Cancer cell 2022 Wolf DM, Yau C, Wulfkuhle J, Brown-Swigart L, Gallagher RI, Lee PRE, Zhu Z, Magbanua MJ, Sayaman R, O'Grady N, Basu A, Delson A, Coppé JP, Lu R, Braun J, I-SPY2 Investigators, Asare SM, Sit L, …
• A protein interaction landscape of breast cancer.
  Science (New York, N.Y.) 2021 Kim M, Park J, Bouhaddou M, Kim K, Rojc A, Modak M, Soucheray M, McGregor MJ, O'Leary P, Wolf D, Stevenson E, Foo TK, Mitchell D, Herrington KA, Muñoz DP, Tutuncuoglu B, Chen KH, Zheng F, Kreisberg JF…
• Non-canonical ATM/MRN activities temporally define the senescence secretory program.
  EMBO reports 2020 Malaquin N, Olivier MA, Martinez A, Nadeau S, Sawchyn C, Coppé JP, Cardin G, Mallette FA, Campisi J, Rodier F

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• Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.
  Aging cell 2019 Xu Q, Long Q, Zhu D, Fu D, Zhang B, Han L, Qian M, Guo J, Xu J, Cao L, Chin YE, Coppé JP, Lam EW, Campisi J, Sun Y
• Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging.
  JCI insight 2019 Muñoz DP, Yannone SM, Daemen A, Sun Y, Vakar-Lopez F, Kawahara M, Freund AM, Rodier F, Wu JD, Desprez PY, Raulet DH, Nelson PS, van 't Veer LJ, Campisi J, Coppé JP
• Mapping phospho-catalytic dependencies of therapy-resistant tumours reveals actionable vulnerabilities.
  Nature cell biology 2019 Coppé JP, Mori M, Pan B, Yau C, Wolf DM, Ruiz-Saenz A, Brunen D, Prahallad A, Cornelissen-Steijger P, Kemper K, Posch C, Wang C, Dreyer CA, Krijgsman O, Lee PRE, Chen Z, Peeper DS, Moasser MM, …
• Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance.
  Nature communications 2018 Chen F, Long Q, Fu D, Zhu D, Ji Y, Han L, Zhang B, Xu Q, Liu B, Li Y, Wu S, Yang C, Qian M, Xu J, Liu S, Cao L, Chin YE, Lam EW, Coppé JP, Sun Y
• Cellular Senescence: The Sought or the Unwanted?
  Trends in molecular medicine 2018 Sun Y, Coppé JP, Lam EW
• Heterogeneous drug penetrance of veliparib and carboplatin measured in triple negative breast tumors.
  Breast cancer research : BCR 2017 Bartelink IH, Prideaux B, Krings G, Wilmes L, Lee PRE, Bo P, Hann B, Coppé JP, Heditsian D, Swigart-Brown L, Jones EF, Magnitsky S, Keizer RJ, de Vries N, Rosing H, Pawlowska N, Thomas S, Dhawan M, …
• An Atlas of the Human Kinome Reveals the Mutational Landscape Underlying Dysregulated Phosphorylation Cascades in Cancer.
  Cancer research 2016 Olow A, Chen Z, Niedner RH, Wolf DM, Yau C, Pankov A, Lee EP, Brown-Swigart L, van 't Veer LJ, Coppé JP
• Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Muñoz DP, Lee EL, Takayama S, Coppé JP, Heo SJ, Boffelli D, Di Noia JM, Martin DI
• p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes.
  The Journal of cell biology 2013 Davalos AR, Kawahara M, Malhotra GK, Schaum N, Huang J, Ved U, Beausejour CM, Coppe JP, Rodier F, Campisi J
• Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.
  The Journal of biological chemistry 2011 Coppé JP, Rodier F, Patil CK, Freund A, Desprez PY, Campisi J
• Metallic nanocone array photonic substrate for high-uniformity surface deposition and optical detection of small molecules.
  Nanotechnology 2011 Coppé JP, Xu Z, Chen Y, Liu GL
• GROα regulates human embryonic stem cell self-renewal or adoption of a neuronal fate.
  Differentiation; research in biological diversity 2011 Krtolica A, Larocque N, Genbacev O, Ilic D, Coppe JP, Patil CK, Zdravkovic T, McMaster M, Campisi J, Fisher SJ
• DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion.
  Journal of cell science 2010 Rodier F, Muñoz DP, Teachenor R, Chu V, Le O, Bhaumik D, Coppé JP, Campeau E, Beauséjour CM, Kim SH, Davalos AR, Campisi J
• Senescent cells as a source of inflammatory factors for tumor progression.
  Cancer metastasis reviews 2010 Davalos AR, Coppe JP, Campisi J, Desprez PY
• The helix-loop-helix Id-1 inhibits PSA expression in prostate cancer cells.
  International journal of cancer 2010 Zielinski AJ, Fong S, Allison J, Kawahara M, Coppe JP, Feiler H, Lee NM, Desprez PY
• Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status.
  Aging cell 2010 Le ON, Rodier F, Fontaine F, Coppe JP, Campisi J, DeGregori J, Laverdière C, Kokta V, Haddad E, Beauséjour CM
• A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen.
  PloS one 2010 Coppé JP, Patil CK, Rodier F, Krtolica A, Beauséjour CM, Parrinello S, Hodgson JG, Chin K, Desprez PY, Campisi J
• The senescence-associated secretory phenotype: the dark side of tumor suppression.
  Annual review of pathology 2010 Coppé JP, Desprez PY, Krtolica A, Campisi J
• Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.
  Nature cell biology 2009 Rodier F, Coppé JP, Patil CK, Hoeijmakers WA, Muñoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J
• Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.
  PLoS biology 2008 Coppé JP, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J
• A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion.
  Molecular cancer research : MCR 2008 Coppe JP, Boysen M, Sun CH, Wong BJ, Kang MK, Park NH, Desprez PY, Campisi J, Krtolica A
• A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
  Cancer cell 2006 Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F, Speed T, Spellman PT, DeVries S, Lapuk A, Wang NJ, Kuo WL, Stilwell JL, Pinkel D, Albertson DG, Waldman FM…
• Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence.
  The Journal of biological chemistry 2006 Coppé JP, Kauser K, Campisi J, Beauséjour CM
• Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation.
  Journal of cell science 2005 Parrinello S, Coppe JP, Krtolica A, Campisi J
• Id-1 and Id-2 proteins as molecular markers for human prostate cancer progression.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2004 Coppe JP, Itahana Y, Moore DH, Bennington JL, Desprez PY
• Role of Id-2 in the maintenance of a differentiated and noninvasive phenotype in breast cancer cells.
  Cancer research 2003 Itahana Y, Singh J, Sumida T, Coppe JP, Parrinello S, Bennington JL, Desprez PY
• Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Fong S, Itahana Y, Sumida T, Singh J, Coppe JP, Liu Y, Richards PC, Bennington JL, Lee NM, Debs RJ, Desprez PY
• Id proteins in epithelial cells.
  Experimental cell research 2003 Coppé JP, Smith AP, Desprez PY
• Helix-loop-helix proteins in mammary gland development and breast cancer.
  Journal of mammary gland biology and neoplasia 2003 Desprez PY, Sumida T, Coppé JP